Homo sapiens

0 known processes

CNDP2

CNDP dipeptidase 2 (metallopeptidase M20 family)

(Aliases: CN2,FLJ10830,CPGL,HsT2298,PEPA,FLJ35544)

CNDP2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amino acid metabolic processGO:00065201160.068
Yeast
post embryonic developmentGO:000979120.066
amine metabolic processGO:0009308440.052
cellular amine metabolic processGO:0044106410.050
cellular ketone metabolic processGO:0042180800.046
determination of adult lifespanGO:000834020.043
regulation of cellular amino acid metabolic processGO:000652160.042
regulation of cellular amine metabolic processGO:0033238110.041
multicellular organismal agingGO:001025930.040
lipid metabolic processGO:00066293810.038
regulation of cellular ketone metabolic processGO:0010565500.037
positive regulation of cellular amino acid metabolic processGO:004576430.037
female gamete generationGO:000729220.036
ribonucleoside triphosphate catabolic processGO:00092033910.036
locomotory behaviorGO:000762610.035
purine ribonucleoside metabolic processGO:00461284370.034
nucleoside triphosphate metabolic processGO:00091414220.034
purine containing compound catabolic processGO:00725234110.033
positive regulation of cellular amine metabolic processGO:003324070.033
single organism membrane organizationGO:00448022680.032
ribonucleoside catabolic processGO:00424544060.032
organophosphate catabolic processGO:00464344300.032
glycosyl compound catabolic processGO:19016584130.032
nucleoside catabolic processGO:00091644080.032
nucleoside phosphate catabolic processGO:19012924120.031
ribonucleoside triphosphate metabolic processGO:00091994120.031
carbohydrate metabolic processGO:00059752070.031
cytoplasmic transportGO:00164823790.030
purine ribonucleoside triphosphate catabolic processGO:00092073910.030
cellular lipid metabolic processGO:00442553030.030
purine nucleoside triphosphate metabolic processGO:00091444120.030
oogenesisGO:004847720.030
purine ribonucleotide catabolic processGO:00091544040.030
purine ribonucleoside triphosphate metabolic processGO:00092054110.030
membrane organizationGO:00610242920.030
negative regulation of protein metabolic processGO:00512483910.030
positive regulation of hydrolase activityGO:00513453310.029
purine nucleotide catabolic processGO:00061954050.029
ribonucleotide catabolic processGO:00092614050.029
purine ribonucleoside catabolic processGO:00461303980.029
ras protein signal transductionGO:0007265730.029
nucleotide catabolic processGO:00091664080.028
single organism cellular localizationGO:19025803320.028
purine nucleoside triphosphate catabolic processGO:00091463920.028
cellular macromolecule catabolic processGO:00442653800.028
negative regulation of cellular protein metabolic processGO:00322693530.028
small gtpase mediated signal transductionGO:0007264780.028
nucleoside triphosphate catabolic processGO:00091433940.027
single organism carbohydrate metabolic processGO:00447231930.027
protein o linked glycosylation via serineGO:001824230.027
transmembrane transportGO:00550853990.027
neuromuscular junction developmentGO:000752830.027
purine nucleoside catabolic processGO:00061523980.027
positive regulation of transportGO:00510503360.027
regulation of proteolysisGO:00301622930.026
immune responseGO:00069553070.026
system processGO:00030083490.026
negative regulation of catalytic activityGO:00430863350.026
cellular response to dna damage stimulusGO:00069743790.026
chemical homeostasisGO:00488783060.026
regulation of cell cycleGO:00517263930.026
positive regulation of cellular component organizationGO:00511303760.025
vesicle mediated transportGO:00161923710.025
protein catabolic processGO:00301633250.025
intracellular protein transportGO:00068862700.025
protein localization to organelleGO:00333652800.025
organonitrogen compound biosynthetic processGO:19015662000.025
positive regulation of cell deathGO:00109422630.024
protein maturationGO:00516042330.024
positive regulation of catabolic processGO:00098963100.024
small molecule biosynthetic processGO:00442831570.023
positive regulation of phosphorylationGO:00423273940.023
actin filament based processGO:00300292240.023
biological adhesionGO:00226103310.023
defense responseGO:00069523150.023
regulation of protein localizationGO:00328802960.023
negative regulation of phosphorus metabolic processGO:00105632670.023
oxidation reduction processGO:00551143960.023
cation transportGO:00068123310.022
ion transmembrane transportGO:00342203380.022
segmentationGO:003528240.022
guanosine containing compound catabolic processGO:19010692390.022
cellular macromolecular complex assemblyGO:00346223240.022
lipid biosynthetic processGO:00086101770.022
regulation of transferase activityGO:00513383550.022
rho protein signal transductionGO:0007266260.022
endomembrane system organizationGO:00102561960.022
cellular protein catabolic processGO:00442572610.022
monocarboxylic acid metabolic processGO:00327871850.022
negative regulation of phosphate metabolic processGO:00459362670.022
mitotic cell cycleGO:00002783260.021
response to oxygen containing compoundGO:19017003690.021
regenerationGO:003109940.021
inorganic ion transmembrane transportGO:00986602310.021
positive regulation of cellular catabolic processGO:00313312840.021
response to abiotic stimulusGO:00096283360.021
regulation of cellular component movementGO:00512703340.021
regulation of purine nucleotide metabolic processGO:19005422640.021
guanosine containing compound metabolic processGO:19010682440.021
regulation of establishment of protein localizationGO:00702012420.021
ion homeostasisGO:00508012300.021
adult locomotory behaviorGO:000834410.021
proteolysis involved in cellular protein catabolic processGO:00516032440.021
innate immune responseGO:00450871780.021
regulation of nucleotide metabolic processGO:00061402690.021
dephosphorylationGO:00163112090.020
negative regulation of cell deathGO:00605483450.020
nervous system developmentGO:00073992930.020
negative regulation of cellular amine metabolic processGO:003323930.020
signal transduction by phosphorylationGO:00230142970.020
cell morphogenesisGO:00009022960.020
cellular response to endogenous stimulusGO:00714953360.020
peripheral nervous system developmentGO:000742220.020
protein o linked glycosylation via threonineGO:001824340.019
cation homeostasisGO:00550801890.019
circadian behaviorGO:004851220.019
gtp catabolic processGO:00061842370.019
metal ion transportGO:00300012720.019
rhythmic behaviorGO:000762220.019
cellular response to oxygen containing compoundGO:19017012760.019
cellular homeostasisGO:00197251960.019
regulation of cellular response to stressGO:00801352440.019
protein processingGO:00164852260.019
protein localization to membraneGO:00726571600.019
gtp metabolic processGO:00460392390.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
positive regulation of purine nucleotide metabolic processGO:19005442270.019
negative regulation of apoptotic processGO:00430663160.019
cofactor metabolic processGO:0051186870.019
memoryGO:000761330.019
carbohydrate derivative biosynthetic processGO:19011372070.019
organic hydroxy compound metabolic processGO:19016151470.019
cell adhesionGO:00071553250.018
regulation of secretionGO:00510461940.018
anion transportGO:00068201610.018
cardiac muscle cell contractionGO:008600340.018
blastoderm segmentationGO:000735020.018
regulation of cell cycle processGO:00105642660.018
regulation of kinase activityGO:00435493140.018
photoreceptor cell differentiationGO:004653020.018
regulation of response to external stimulusGO:00321012220.018
spermatid differentiationGO:004851540.018
oocyte differentiationGO:000999420.018
posttranscriptional regulation of gene expressionGO:00106082130.018
negative regulation of multicellular organismal processGO:00512413170.018
positive regulation of apoptotic processGO:00430652460.018
regulation of peptidase activityGO:00525471800.018
cation transmembrane transportGO:00986552380.018
reactive oxygen species biosynthetic processGO:190340940.018
mitotic cell cycle processGO:19030472860.018
negative regulation of programmed cell deathGO:00430693210.018
apoptotic signaling pathwayGO:00971902680.018
positive regulation of programmed cell deathGO:00430682490.018
positive regulation of nucleotide metabolic processGO:00459812300.018
regulation of synaptic plasticityGO:004816730.018
oocyte developmentGO:004859910.018
inorganic cation transmembrane transportGO:00986621940.018
cellular component morphogenesisGO:00329893140.018
regulation of intracellular transportGO:00323861950.018
protein targetingGO:00066051870.018
negative regulation of cellular component organizationGO:00511292350.018
positive regulation of immune system processGO:00026842830.018
morphogenesis of embryonic epitheliumGO:001633140.017
anterior posterior axis specificationGO:000994820.017
regulation of protein transportGO:00512232130.017
regulation of protein kinase activityGO:00458592890.017
sulfur compound metabolic processGO:00067901010.017
Yeast
regulation of anatomical structure morphogenesisGO:00226032860.017
embryonic epithelial tube formationGO:000183840.017
regulation of nucleoside metabolic processGO:00091182090.017
reactive oxygen species metabolic processGO:0072593750.017
regulation of locomotionGO:00400123290.017
mapk cascadeGO:00001652880.017
response to cytokineGO:00340972320.017
secretion by cellGO:00329402260.017
regulation of reactive oxygen species biosynthetic processGO:190342630.017
associative learningGO:000830610.017
response to external biotic stimulusGO:00432072610.017
maintenance of locationGO:00512351120.017
carboxylic acid biosynthetic processGO:0046394970.017
secretionGO:00469032540.017
anterior posterior axis specification embryoGO:000859520.017
negative regulation of intracellular signal transductionGO:19025321830.017
positive regulation of nucleoside metabolic processGO:00459791860.017
protein modification by small protein conjugationGO:00324463420.017
positive regulation of synaptic transmissionGO:005080640.017
organophosphate biosynthetic processGO:00904071630.017
nitrogen compound transportGO:00717051910.017
proteasomal protein catabolic processGO:00104981760.017
neurological system processGO:00508771630.017
neurotransmitter secretionGO:000726940.017
regulation of cell motilityGO:20001452990.016
release of cytoplasmic sequestered nf kappabGO:000858840.016
reactive nitrogen species metabolic processGO:200105730.016
regulation of cellular component biogenesisGO:00440872810.016
response to other organismGO:00517072610.016
response to biotic stimulusGO:00096072760.016
positive regulation of purine nucleotide catabolic processGO:00331231850.016
negative regulation of protein modification processGO:00314002000.016
organic acid biosynthetic processGO:0016053970.016
cellular response to cytokine stimulusGO:00713451810.016
cellular cation homeostasisGO:00300031630.016
regulation of mapk cascadeGO:00434082620.016
glycoprotein metabolic processGO:00091001100.016
regulation of nucleotide catabolic processGO:00308112050.016
negative regulation of hydrolase activityGO:00513461820.016
protein ubiquitinationGO:00165673140.016
cell projection organizationGO:00300302520.016
regulation of cell migrationGO:00303342890.016
regulation of purine nucleotide catabolic processGO:00331212050.016
interspecies interaction between organismsGO:00444191560.016
spermatid developmentGO:000728640.016
regulation of protein catabolic processGO:00421761550.016
purine nucleoside monophosphate metabolic processGO:00091261860.016
regulation of cell differentiationGO:00455953930.016
modification dependent protein catabolic processGO:00199412090.015
cell developmentGO:00484683280.015
alcohol metabolic processGO:00060661140.015
regulation of endopeptidase activityGO:00525481700.015
chromatin organizationGO:00063253510.015
cellular ion homeostasisGO:00068731680.015
motor neuron axon guidanceGO:000804520.015
modification dependent macromolecule catabolic processGO:00436322120.015
atp metabolic processGO:00460341760.015
positive regulation of nucleotide catabolic processGO:00308131850.015
ubiquitin dependent protein catabolic processGO:00065112060.015
regulation of cytokine productionGO:00018172320.015
negative regulation of cell proliferationGO:00082852280.015
covalent chromatin modificationGO:00165692540.015
purine ribonucleoside monophosphate metabolic processGO:00091671860.015
metal ion homeostasisGO:00550651690.015
positive regulation of cell proliferationGO:00082843010.015
cellular chemical homeostasisGO:00550821800.015
hindbrain developmentGO:003090230.015
rna processingGO:00063962550.015
inner ear morphogenesisGO:004247240.015
histone modificationGO:00165702510.015
enzyme linked receptor protein signaling pathwayGO:00071673030.015
small molecule catabolic processGO:0044282920.015
Yeast
compound eye developmentGO:004874910.015
actin cytoskeleton organizationGO:00300362070.015
tripartite regional subdivisionGO:000735120.015
nucleoside monophosphate metabolic processGO:00091231910.014
chromatin modificationGO:00165682980.014
organ formationGO:004864530.014
cellular protein complex assemblyGO:00436231880.014
actin filament based movementGO:0030048170.014
protein oligomerizationGO:00512591730.014
regulation of neural precursor cell proliferationGO:200017740.014
positive regulation of protein phosphorylationGO:00019343130.014
negative regulation of cell cycleGO:00457861930.014
nerve developmentGO:002167540.014
cellular metal ion homeostasisGO:00068751460.014
regulation of protein maturationGO:19033171500.014
establishment of protein localization to organelleGO:00725941720.014
regulation of gtpase activityGO:00430871800.014
response to fungusGO:000962040.014
positive regulation of organelle organizationGO:00106381950.014
mitochondrion organizationGO:00070051560.014
matingGO:000761810.014
negative regulation of transportGO:00510511760.014
ribonucleoside monophosphate metabolic processGO:00091611870.014
plasma membrane organizationGO:00070091150.014
circulatory system developmentGO:00723592620.014
endosomal transportGO:00161971290.014
establishment of protein localization to membraneGO:00901501210.014
negative regulation of developmental processGO:00510932470.014
rna interferenceGO:001624640.014
regulation of reactive oxygen species metabolic processGO:2000377410.014
negative regulation of phosphorylationGO:00423261740.014
cardiovascular system developmentGO:00723582620.014
organic anion transportGO:00157111030.014
regulation of gtp catabolic processGO:00331241800.014
regulation of sequence specific dna binding transcription factor activityGO:00510902110.014
cell cycle phase transitionGO:00447701730.014
neuroblast proliferationGO:000740540.014
actin mediated cell contractionGO:0070252120.014
organelle assemblyGO:00709251760.014
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.014
symbiosis encompassing mutualism through parasitismGO:00444031560.014
response to nitrogen compoundGO:19016981840.014
sequestering of metal ionGO:0051238240.014
morphogenesis of a polarized epitheliumGO:000173830.014
syncytium formation by plasma membrane fusionGO:000076820.014
neural tube formationGO:000184130.014
coenzyme metabolic processGO:0006732650.014
response to axon injuryGO:004867810.013
anatomical structure formation involved in morphogenesisGO:00486462840.013
positive regulation of gtpase activityGO:00435471660.013
regulation of immune responseGO:00507762010.013
startle responseGO:000196430.013
cell fate determinationGO:000170930.013
sensory perception of painGO:001923340.013
regulation of cysteine type endopeptidase activityGO:20001161270.013
spinal cord developmentGO:002151040.013
visual behaviorGO:000763220.013
glycerolipid metabolic processGO:00464861070.013
fatty acid metabolic processGO:00066311150.013
multi organism cellular processGO:00447641560.013
regulation of vesicle mediated transportGO:00606271300.013
positive regulation of transferase activityGO:00513472270.013
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.013
positive regulation of secretionGO:00510471160.013
microtubule based processGO:00070172100.013
lipid catabolic processGO:0016042840.013
regulation of secretion by cellGO:19035301770.013
regulation of multi organism processGO:00439001570.013
positive regulation of proteolysisGO:00458621420.013
positive regulation of gtp catabolic processGO:00331261660.013
metencephalon developmentGO:002203720.013
cell activationGO:00017752130.013
regulation of cytoskeleton organizationGO:00514931770.013
regulation of cytoplasmic transportGO:19036491490.013
regulation of small gtpase mediated signal transductionGO:00510561560.013
negative regulation of protein maturationGO:19033181420.013
negative regulation of protein processingGO:00109551420.013
meiosis iGO:000712740.013
regulation of mitotic cell cycleGO:00073461890.013
epithelium developmentGO:00604292270.013
growthGO:00400072020.013
regulation of ras protein signal transductionGO:00465781550.013
nucleocytoplasmic transportGO:00069131760.013
nuclear transportGO:00511691790.013
response to growth factorGO:00708482050.013
salivary gland morphogenesisGO:000743540.013
cytokine productionGO:00018162470.013
positive regulation of reactive oxygen species biosynthetic processGO:190342820.013
response to lipidGO:00339932060.013
regulation of protein processingGO:00706131500.013
regulation of meiotic cell cycleGO:005144540.012
stem cell divisionGO:001714520.012
tube closureGO:006060630.012
limbic system developmentGO:002176130.012
regulation of apoptotic signaling pathwayGO:20012331750.012
primary neural tube formationGO:001402030.012
mitotic cell cycle phase transitionGO:00447721620.012
monocarboxylic acid biosynthetic processGO:0072330670.012
cell growthGO:00160491600.012
detection of muramyl dipeptideGO:003249810.012
regulation of membrane potentialGO:0042391950.012
regulation of neurotransmitter secretionGO:004692830.012
negative regulation of proteolysisGO:00458611320.012
endocytosisGO:00068971590.012
divalent inorganic cation homeostasisGO:00725071360.012
viral processGO:00160321460.012
sequestering of calcium ionGO:0051208170.012
cell projection assemblyGO:00300311260.012
positive regulation of developmental processGO:00510943140.012
response to organic cyclic compoundGO:00140702040.012
tissue regenerationGO:004224630.012
cell divisionGO:00513011680.012
positive regulation of kinase activityGO:00336742040.012
regulation of transcription from rna polymerase ii promoter mitoticGO:004602110.012
nucleoside monophosphate catabolic processGO:00091251590.012
negative regulation of protein phosphorylationGO:00019331400.012
regulation of i kappab kinase nf kappab signalingGO:00431221620.012
regulation of protein complex assemblyGO:00432541470.012
epidermis morphogenesisGO:004873030.012
cellular response to growth factor stimulusGO:00713631970.012
myoblast fusionGO:000752010.012
dna repairGO:00062811980.012
developmental programmed cell deathGO:001062330.012
carboxylic acid catabolic processGO:0046395710.012
Yeast
sleepGO:003043120.012
positive regulation of cellular component biogenesisGO:00440891580.012
i kappab kinase nf kappab signalingGO:00072491660.012
hemopoiesisGO:00300971800.012
regulation of ion transportGO:00432691890.012
long term memoryGO:000761620.012
divalent metal ion transportGO:00708381520.012
regulation of transcription during mitosisGO:004589620.012
nucleoside phosphate biosynthetic processGO:19012931090.012
response to hormoneGO:00097251750.012
retinoic acid biosynthetic processGO:000213820.012
monovalent inorganic cation transportGO:00156721280.011
sex determinationGO:000753030.011
protein acylationGO:00435431380.011
regulation of ras gtpase activityGO:00323181280.011
positive regulation of cytokine productionGO:00018191670.011
regulation of growthGO:00400081650.011
positive regulation of cell differentiationGO:00455972110.011
positive regulation of cellular component movementGO:00512721810.011
neurogenesisGO:00220081690.011
regulation of protein serine threonine kinase activityGO:00719001790.011
response to organonitrogen compoundGO:00102431560.011
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.011
vasodilationGO:004231140.011
sensory perception of smellGO:000760820.011
positive regulation of cell migrationGO:00303351720.011
negative regulation of blood pressureGO:004577630.011
cdc42 protein signal transductionGO:003248840.011
atp catabolic processGO:00062001570.011
viral life cycleGO:00190581320.011
cerebellum developmentGO:002154920.011
regulation of hormone levelsGO:00108171250.011
cellular lipid catabolic processGO:0044242650.011
cellular modified amino acid metabolic processGO:0006575640.011
Yeast
positive regulation of secretion by cellGO:19035321080.011
negative regulation of organelle organizationGO:00106391260.011
rab protein signal transductionGO:003248240.011
positive regulation of transcription from rna polymerase ii promoter during mitosisGO:004602210.011
protein homooligomerizationGO:00512601000.011
positive regulation of mapk cascadeGO:00434101900.011
establishment of planar polarityGO:000173630.011
regulation of cell adhesionGO:00301551660.011
purine ribonucleoside monophosphate catabolic processGO:00091691580.011
neural tube closureGO:000184330.011
organic hydroxy compound biosynthetic processGO:1901617710.011
response to inorganic substanceGO:00100351270.011
positive regulation of ras gtpase activityGO:00323201170.011
positive regulation of neural precursor cell proliferationGO:200017920.011
wnt signaling pathwayGO:00160551560.011
regulation of intracellular protein transportGO:00331571230.011
glial cell migrationGO:000834740.011
post embryonic organ developmentGO:004856910.011
t cell differentiation in thymusGO:003307740.011
establishment or maintenance of apical basal cell polarityGO:003508820.011
positive regulation of protein transportGO:00512221350.011
divalent inorganic cation transportGO:00725111580.011
single organism cell adhesionGO:00986021790.011
lung alveolus developmentGO:004828640.011
positive regulation of reactive oxygen species metabolic processGO:2000379240.011
positive regulation of transcription during mitosisGO:004589720.011
thymus developmentGO:004853830.011
regulation of dna metabolic processGO:00510521530.011
establishment or maintenance of bipolar cell polarityGO:006124520.011
alpha amino acid metabolic processGO:1901605720.011
immune effector processGO:00022521590.011
lipid transportGO:0006869900.011
response to virusGO:00096151260.011
negative regulation of transferase activityGO:00513481240.011
defense response to fungusGO:005083240.011
positive regulation of protein kinase activityGO:00458601900.011
positive regulation of gliogenesisGO:001401540.011
central nervous system developmentGO:00074171230.011
establishment of tissue polarityGO:000716430.011
specification of organ identityGO:001009230.011
regulation of cell morphogenesisGO:00226041530.011
meiotic chromosome segregationGO:004513240.011
organic acid catabolic processGO:0016054710.011
Yeast
postsynaptic membrane organizationGO:000194120.011
phospholipid metabolic processGO:0006644990.011
cellular response to nitrogen compoundGO:19016991440.011
regulation of defense responseGO:00313471540.011
visual learningGO:000854210.011
purine nucleoside monophosphate catabolic processGO:00091281580.011
cell part morphogenesisGO:00329901370.011
lipid localizationGO:00108761060.011
cellular response to organonitrogen compoundGO:00714171240.011
somatic muscle developmentGO:000752510.011
immune system developmentGO:00025201950.011
glycoprotein biosynthetic processGO:0009101910.011
cell cycle checkpointGO:00000751170.011
positive regulation of cell motilityGO:20001471770.011
protein localization to nucleusGO:00345041360.011
peptidyl tyrosine modificationGO:00182121700.011
positive regulation of immune responseGO:00507781590.011
microtubule cytoskeleton organizationGO:00002261760.011
ribonucleoside monophosphate catabolic processGO:00091581580.011
nucleotide biosynthetic processGO:00091651090.010
regulation of actin filament based processGO:00329701410.010
positive regulation of cell cycleGO:00457871400.010
forelimb morphogenesisGO:003513640.010
peptidyl tyrosine phosphorylationGO:00181081700.010
monosaccharide metabolic processGO:0005996740.010
negative regulation of synaptic transmissionGO:005080520.010

CNDP2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
inherited metabolic disorderDOID:6552420.057
disease of metabolismDOID:00146672950.057
musculoskeletal system diseaseDOID:172230.025
nervous system diseaseDOID:8634310.024
sensory system diseaseDOID:00501552030.024
central nervous system diseaseDOID:3311860.021
immune system diseaseDOID:29141550.021
disease of cellular proliferationDOID:145661740.020
cancerDOID:1621670.020
eye and adnexa diseaseDOID:14921500.019
eye diseaseDOID:56141490.019
organ system cancerDOID:00506861640.018
connective tissue diseaseDOID:651090.015
retinal diseaseDOID:56791180.015
neurodegenerative diseaseDOID:12891020.014
cardiovascular system diseaseDOID:12871060.014
muscle tissue diseaseDOID:661130.014
muscular diseaseDOID:00800001140.014
myopathyDOID:4231040.014
amino acid metabolic disorderDOID:9252500.014
bone diseaseDOID:0080001880.014
hematopoietic system diseaseDOID:741000.013
retinal degenerationDOID:8466890.013
brain diseaseDOID:936730.012
disease of mental healthDOID:150700.012
carbohydrate metabolic disorderDOID:2978550.011
lysosomal storage diseaseDOID:3211470.010