Homo sapiens

124 known processes

HTRA2

HtrA serine peptidase 2

(Aliases: PRSS25,OMI,PARK13)

HTRA2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
protein catabolic processGO:00301633250.170
protein modification by small protein conjugationGO:00324463420.165
proteolysis involved in cellular protein catabolic processGO:00516032440.132
protein ubiquitinationGO:00165673140.128
negative regulation of cell deathGO:00605483450.124
Rat
positive regulation of apoptotic processGO:00430652460.116
negative regulation of programmed cell deathGO:00430693210.115
positive regulation of cell deathGO:00109422630.109
negative regulation of cellular protein metabolic processGO:00322693530.107
negative regulation of protein metabolic processGO:00512483910.098
cellular response to dna damage stimulusGO:00069743790.096
negative regulation of intracellular signal transductionGO:19025321830.094
modification dependent protein catabolic processGO:00199412090.092
negative regulation of apoptotic processGO:00430663160.091
cellular protein catabolic processGO:00442572610.088
protein processingGO:00164852260.083
protein maturationGO:00516042330.080
negative regulation of proteolysisGO:00458611320.078
cellular amino acid metabolic processGO:00065201160.075
response to abiotic stimulusGO:00096283360.075
negative regulation of protein maturationGO:19033181420.072
regulation of protein maturationGO:19033171500.071
negative regulation of protein processingGO:00109551420.071
regulation of cell differentiationGO:00455953930.063
positive regulation of cellular amine metabolic processGO:003324070.062
positive regulation of programmed cell deathGO:00430682490.059
regulation of proteolysisGO:00301622930.058
negative regulation of developmental processGO:00510932470.058
negative regulation of catalytic activityGO:00430863350.057
regulation of cellular amine metabolic processGO:0033238110.055
positive regulation of cellular amino acid metabolic processGO:004576430.055
regulation of cellular ketone metabolic processGO:0010565500.049
small gtpase mediated signal transductionGO:0007264780.049
regulation of cellular response to stressGO:00801352440.049
regulation of transferase activityGO:00513383550.048
cellular amine metabolic processGO:0044106410.047
response to oxygen containing compoundGO:19017003690.047
positive regulation of transferase activityGO:00513472270.047
ubiquitin dependent protein catabolic processGO:00065112060.044
response to cytokineGO:00340972320.044
response to light stimulusGO:0009416870.044
positive regulation of response to dna damage stimulusGO:2001022430.042
response to radiationGO:00093141510.042
amine metabolic processGO:0009308440.042
negative regulation of apoptotic signaling pathwayGO:2001234970.040
positive regulation of developmental processGO:00510943140.040
cellular response to cytokine stimulusGO:00713451810.037
regulation of protein catabolic processGO:00421761550.037
i kappab kinase nf kappab signalingGO:00072491660.037
regulation of i kappab kinase nf kappab signalingGO:00431221620.037
regulation of protein processingGO:00706131500.036
positive regulation of cell differentiationGO:00455972110.036
regulation of cellular amino acid metabolic processGO:000652160.035
regulation of cell cycle processGO:00105642660.034
dna repairGO:00062811980.034
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.033
regulation of dna metabolic processGO:00510521530.032
cellular ketone metabolic processGO:0042180800.032
cellular response to endogenous stimulusGO:00714953360.032
apoptotic signaling pathwayGO:00971902680.031
immune responseGO:00069553070.031
post embryonic developmentGO:000979120.030
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.030
protein oligomerizationGO:00512591730.029
modification dependent macromolecule catabolic processGO:00436322120.029
system processGO:00030083490.028
locomotory behaviorGO:000762610.028
Mouse
protein homooligomerizationGO:00512601000.028
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.027
positive regulation of immune system processGO:00026842830.027
establishment of protein localization to organelleGO:00725941720.027
positive regulation of protein phosphorylationGO:00019343130.027
defense responseGO:00069523150.027
multicellular organismal agingGO:001025930.027
regulation of cysteine type endopeptidase activityGO:20001161270.027
pharynx developmentGO:006046510.026
cell cycle arrestGO:0007050710.026
cellular response to lipidGO:00713961270.025
hemopoiesisGO:00300971800.025
regulation of cellular protein catabolic processGO:1903362960.025
epithelium developmentGO:00604292270.025
response to uvGO:0009411730.025
ras protein signal transductionGO:0007265730.024
proteasomal protein catabolic processGO:00104981760.024
oogenesisGO:004847720.024
dna demethylationGO:0080111120.023
coenzyme metabolic processGO:0006732650.023
positive regulation of cell cycle processGO:00900681060.023
monocarboxylic acid metabolic processGO:00327871850.023
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.023
regulation of protein ubiquitinationGO:0031396950.023
oocyte developmentGO:004859910.023
nervous system developmentGO:00073992930.022
Mouse
response to biotic stimulusGO:00096072760.022
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.022
regulation of peptidase activityGO:00525471800.022
regulation of response to dna damage stimulusGO:2001020940.022
positive regulation of apoptotic signaling pathwayGO:2001235700.022
cell divisionGO:00513011680.022
cellular macromolecule catabolic processGO:00442653800.022
negative regulation of cellular catabolic processGO:0031330830.022
protein acetylationGO:00064731160.022
chromatin modificationGO:00165682980.022
negative regulation of catabolic processGO:00098951040.022
intracellular protein transportGO:00068862700.021
positive regulation of cell cycleGO:00457871400.021
positive regulation of protein ubiquitinationGO:0031398530.021
regulation of leukocyte activationGO:00026941150.021
cellular response to growth factor stimulusGO:00713631970.021
extrinsic apoptotic signaling pathwayGO:00971911190.021
positive regulation of hydrolase activityGO:00513453310.021
cellular lipid metabolic processGO:00442553030.021
Rat
growthGO:00400072020.021
Mouse
immune effector processGO:00022521590.020
intrinsic apoptotic signaling pathwayGO:00971931270.020
cell growthGO:00160491600.020
regulation of cell cycleGO:00517263930.020
negative regulation of protein modification processGO:00314002000.020
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.020
regulation of leukocyte differentiationGO:1902105610.020
neurogenesisGO:00220081690.020
Mouse
protein polyubiquitinationGO:00002091100.020
demethylationGO:0070988370.020
regulation of protein kinase activityGO:00458592890.020
protein acylationGO:00435431380.020
response to inorganic substanceGO:00100351270.020
positive regulation of myeloid cell differentiationGO:0045639390.019
regulation of kinase activityGO:00435493140.019
protein localization to organelleGO:00333652800.019
determination of adult lifespanGO:000834020.019
negative regulation of peptidase activityGO:0010466910.019
positive regulation of phosphorylationGO:00423273940.019
dephosphorylationGO:00163112090.018
regulation of transcription during mitosisGO:004589620.018
purine ribonucleotide catabolic processGO:00091544040.018
transmembrane transportGO:00550853990.018
regulation of viral processGO:00507921030.018
methylationGO:00322591060.018
covalent chromatin modificationGO:00165692540.018
actin mediated cell contractionGO:0070252120.018
ribonucleoside catabolic processGO:00424544060.018
secretion by cellGO:00329402260.018
sulfur compound metabolic processGO:00067901010.018
positive regulation of protein modification by small protein conjugation or removalGO:1903322610.017
negative regulation of cell cycleGO:00457861930.017
positive regulation of bindingGO:0051099450.017
positive regulation of organelle organizationGO:00106381950.017
positive regulation of cytokine productionGO:00018191670.017
positive regulation of myeloid leukocyte differentiationGO:0002763240.017
female gamete generationGO:000729220.017
neurological system processGO:00508771630.017
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.017
regulation of protein modification by small protein conjugation or removalGO:19033201070.017
cranial nerve developmentGO:002154540.016
protein polymerizationGO:0051258710.016
innate immune responseGO:00450871780.016
cellular response to abiotic stimulusGO:00712141170.016
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.016
urogenital system developmentGO:0001655650.016
posttranscriptional regulation of gene expressionGO:00106082130.016
organophosphate catabolic processGO:00464344300.016
response to woundingGO:00096111680.016
response to metal ionGO:0010038840.016
regulation of apoptotic signaling pathwayGO:20012331750.016
response to organic cyclic compoundGO:00140702040.016
atp metabolic processGO:00460341760.016
cellular protein complex assemblyGO:00436231880.016
protein autophosphorylationGO:00467771230.016
regulation of bindingGO:00510981110.016
response to other organismGO:00517072610.016
histone modificationGO:00165702510.016
negative regulation of cell differentiationGO:00455961710.016
regulation of protein serine threonine kinase activityGO:00719001790.015
cell cycle phase transitionGO:00447701730.015
cell cycle checkpointGO:00000751170.015
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.015
dna integrity checkpointGO:0031570710.015
macromolecule methylationGO:0043414970.015
response to growth factorGO:00708482050.015
cofactor metabolic processGO:0051186870.015
peptidyl serine phosphorylationGO:00181051010.015
response to lipidGO:00339932060.015
negative regulation of hydrolase activityGO:00513461820.015
apoptotic mitochondrial changesGO:0008637570.015
cellular response to external stimulusGO:00714961110.015
regulation of proteasomal protein catabolic processGO:0061136870.015
response to nitric oxideGO:007173140.015
peptidyl serine modificationGO:00182091060.015
negative regulation of endopeptidase activityGO:0010951840.015
hematopoietic or lymphoid organ developmentGO:00485341860.014
positive regulation of leukocyte differentiationGO:1902107370.014
organelle fissionGO:00482851490.014
response to virusGO:00096151260.014
regulation of protein transportGO:00512232130.014
positive regulation of kinase activityGO:00336742040.014
rho protein signal transductionGO:0007266260.014
nerve developmentGO:002167540.014
maintenance of locationGO:00512351120.014
dna replicationGO:00062601160.014
regulation of establishment of protein localizationGO:00702012420.014
nucleoside catabolic processGO:00091644080.014
cellular macromolecular complex assemblyGO:00346223240.014
meiosis iGO:000712740.013
enzyme linked receptor protein signaling pathwayGO:00071673030.013
negative regulation of cell proliferationGO:00082852280.013
regulation of myeloid cell differentiationGO:0045637810.013
glycosyl compound catabolic processGO:19016584130.013
cytoplasmic transportGO:00164823790.013
cellular response to oxygen containing compoundGO:19017012760.013
symbiosis encompassing mutualism through parasitismGO:00444031560.013
regulation of protein localizationGO:00328802960.013
purine ribonucleoside triphosphate catabolic processGO:00092073910.013
dna damage checkpointGO:0000077680.013
regulation of synaptic plasticityGO:004816730.013
regulation of protein complex assemblyGO:00432541470.013
protein importGO:00170381300.013
regulation of endopeptidase activityGO:00525481700.013
regulation of response to external stimulusGO:00321012220.013
chromatin organizationGO:00063253510.013
ribonucleoside triphosphate catabolic processGO:00092033910.013
negative regulation of phosphorus metabolic processGO:00105632670.013
cell morphogenesisGO:00009022960.013
peptidyl tyrosine phosphorylationGO:00181081700.013
regulation of multi organism processGO:00439001570.013
ribonucleotide catabolic processGO:00092614050.013
regulation of immune responseGO:00507762010.013
reactive oxygen species metabolic processGO:0072593750.013
cell agingGO:0007569520.012
hindbrain developmentGO:003090230.012
response to external biotic stimulusGO:00432072610.012
negative regulation of protein catabolic processGO:0042177590.012
regulation of canonical wnt signaling pathwayGO:0060828880.012
purine nucleoside triphosphate catabolic processGO:00091463920.012
single organism membrane organizationGO:00448022680.012
rna splicingGO:00083801310.012
regulation of chromosome organizationGO:00330441030.012
lipid metabolic processGO:00066293810.012
Rat
secretionGO:00469032540.012
mitotic cell cycleGO:00002783260.012
peptidyl tyrosine modificationGO:00182121700.012
regulation of secretion by cellGO:19035301770.012
myeloid cell differentiationGO:00300991170.012
positive regulation of transportGO:00510503360.012
anatomical structure homeostasisGO:00602491000.012
segmentationGO:003528240.012
negative regulation of multi organism processGO:0043901920.012
nucleoside phosphate catabolic processGO:19012924120.012
purine nucleoside catabolic processGO:00061523980.012
fatty acid metabolic processGO:00066311150.012
purine containing compound catabolic processGO:00725234110.011
actin filament based movementGO:0030048170.011
cranial nerve morphogenesisGO:002160210.011
purine ribonucleoside triphosphate metabolic processGO:00092054110.011
protein localization to nucleusGO:00345041360.011
viral processGO:00160321460.011
nucleoside monophosphate metabolic processGO:00091231910.011
immune system developmentGO:00025201950.011
positive regulation of dna metabolic processGO:0051054730.011
regulation of secretionGO:00510461940.011
negative regulation of dna metabolic processGO:0051053570.011
positive regulation of cysteine type endopeptidase activityGO:2001056790.011
interspecies interaction between organismsGO:00444191560.011
response to lipopolysaccharideGO:0032496700.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.011
regulation of cytoskeleton organizationGO:00514931770.011
optic nerve developmentGO:002155420.011
viral life cycleGO:00190581320.011
leukocyte differentiationGO:0002521980.011
compound eye developmentGO:004874910.011
associative learningGO:000830610.011
defense response to other organismGO:00985421290.011
negative regulation of intrinsic apoptotic signaling pathwayGO:2001243400.011
multi organism cellular processGO:00447641560.011
positive regulation of catabolic processGO:00098963100.011
negative regulation of multicellular organismal processGO:00512413170.011
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.011
ion transmembrane transportGO:00342203380.011
endosomal transportGO:00161971290.010
regulation of cytoplasmic transportGO:19036491490.010
viral release from host cellGO:0019076210.010
axis elongationGO:000340140.010
positive regulation of immune responseGO:00507781590.010
regulation of ras protein signal transductionGO:00465781550.010
cell part morphogenesisGO:00329901370.010
negative regulation of cellular protein catabolic processGO:1903363380.010
cellular homeostasisGO:00197251960.010
positive regulation of cellular component biogenesisGO:00440891580.010
regulation of nucleotide metabolic processGO:00061402690.010
neuromuscular junction developmentGO:000752830.010
single organismal cell cell adhesionGO:00163371480.010

HTRA2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
central nervous system diseaseDOID:3311860.026
nervous system diseaseDOID:8634310.026
cancerDOID:1621670.016
disease of cellular proliferationDOID:145661740.016
organ system cancerDOID:00506861640.016
sensory system diseaseDOID:00501552030.014
Human
neurodegenerative diseaseDOID:12891020.014
musculoskeletal system diseaseDOID:172230.013
disease of metabolismDOID:00146672950.012
parkinson s diseaseDOID:14330180.005
synucleinopathyDOID:0050890220.005