Homo sapiens

27 known processes

MTHFD2

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

(Aliases: NMDMC)

MTHFD2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
trna aminoacylation for protein translationGO:000641880.452
cellular amino acid metabolic processGO:00065201160.448
post embryonic developmentGO:000979120.370
multicellular organismal agingGO:001025930.298
nitrogen compound transportGO:00717051910.197
nucleoside phosphate biosynthetic processGO:19012931090.134
determination of adult lifespanGO:000834020.134
alpha amino acid metabolic processGO:1901605720.133
trna aminoacylationGO:0043039120.129
cellular response to dna damage stimulusGO:00069743790.089
single organism carbohydrate metabolic processGO:00447231930.088
oxidation reduction processGO:00551143960.087
translationGO:00064121320.084
response to oxygen containing compoundGO:19017003690.083
hemopoiesisGO:00300971800.071
small molecule biosynthetic processGO:00442831570.070
ribonucleoside catabolic processGO:00424544060.060
organonitrogen compound biosynthetic processGO:19015662000.057
purine ribonucleoside catabolic processGO:00461303980.057
cellular amino acid biosynthetic processGO:0008652300.056
agingGO:0007568660.056
negative regulation of cellular component organizationGO:00511292350.055
carbohydrate metabolic processGO:00059752070.053
amino acid activationGO:0043038120.052
cytoplasmic transportGO:00164823790.052
glycosyl compound catabolic processGO:19016584130.052
positive regulation of cellular catabolic processGO:00313312840.052
purine ribonucleoside metabolic processGO:00461284370.052
hematopoietic or lymphoid organ developmentGO:00485341860.051
guanosine containing compound metabolic processGO:19010682440.051
organic anion transportGO:00157111030.051
nuclear transportGO:00511691790.050
purine nucleoside catabolic processGO:00061523980.048
purine ribonucleoside triphosphate metabolic processGO:00092054110.047
regulation of cell differentiationGO:00455953930.045
organic hydroxy compound metabolic processGO:19016151470.045
innate immune responseGO:00450871780.045
anion transportGO:00068201610.045
single organism cellular localizationGO:19025803320.044
organophosphate biosynthetic processGO:00904071630.044
regulation of cell developmentGO:00602841610.043
response to nitrogen compoundGO:19016981840.043
positive regulation of hydrolase activityGO:00513453310.043
defense responseGO:00069523150.043
regulation of nucleoside metabolic processGO:00091182090.042
gtp catabolic processGO:00061842370.041
guanosine containing compound catabolic processGO:19010692390.041
immune responseGO:00069553070.040
purine nucleoside triphosphate metabolic processGO:00091444120.040
gtp metabolic processGO:00460392390.040
serine family amino acid metabolic processGO:0009069120.039
regulation of transmembrane transportGO:00347621390.039
regulation of locomotionGO:00400123290.039
organophosphate catabolic processGO:00464344300.038
regulation of translationGO:0006417890.037
ncrna metabolic processGO:00346601080.037
positive regulation of transportGO:00510503360.037
negative regulation of catalytic activityGO:00430863350.037
cellular macromolecule catabolic processGO:00442653800.036
carboxylic acid biosynthetic processGO:0046394970.036
erythrocyte differentiationGO:0030218280.035
regulation of cellular response to stressGO:00801352440.035
ribonucleoside triphosphate catabolic processGO:00092033910.034
regenerationGO:003109940.034
response to external biotic stimulusGO:00432072610.034
apoptotic signaling pathwayGO:00971902680.033
protein catabolic processGO:00301633250.033
monocarboxylic acid metabolic processGO:00327871850.033
negative regulation of protein metabolic processGO:00512483910.033
dna templated transcription terminationGO:000635330.033
signal transduction by phosphorylationGO:00230142970.032
regulation of cellular component movementGO:00512703340.032
regulation of purine nucleotide catabolic processGO:00331212050.032
regulation of cell motilityGO:20001452990.032
response to organic cyclic compoundGO:00140702040.031
purine containing compound catabolic processGO:00725234110.031
amine metabolic processGO:0009308440.031
regulation of mitotic cell cycleGO:00073461890.031
cellular response to endogenous stimulusGO:00714953360.030
ribonucleoside triphosphate metabolic processGO:00091994120.030
purine ribonucleotide catabolic processGO:00091544040.029
nucleoside catabolic processGO:00091644080.029
mitochondrion organizationGO:00070051560.029
negative regulation of phosphate metabolic processGO:00459362670.029
growthGO:00400072020.029
establishment of protein localization to organelleGO:00725941720.029
regulation of dna metabolic processGO:00510521530.028
nucleotide catabolic processGO:00091664080.028
nucleoside triphosphate metabolic processGO:00091414220.027
transmembrane transportGO:00550853990.027
regulation of transferase activityGO:00513383550.027
neurogenesisGO:00220081690.027
female gamete generationGO:000729220.027
regulation of protein localizationGO:00328802960.027
response to woundingGO:00096111680.027
purine containing compound biosynthetic processGO:0072522880.026
negative regulation of cellular protein metabolic processGO:00322693530.026
cellular response to oxygen containing compoundGO:19017012760.026
dna repairGO:00062811980.026
nucleotide biosynthetic processGO:00091651090.026
organic acid biosynthetic processGO:0016053970.026
regulation of cell migrationGO:00303342890.025
leukocyte differentiationGO:0002521980.025
purine nucleoside triphosphate catabolic processGO:00091463920.025
regulation of membrane potentialGO:0042391950.025
positive regulation of cell deathGO:00109422630.025
positive regulation of nucleotide metabolic processGO:00459812300.025
regulation of intracellular transportGO:00323861950.025
negative regulation of cell migrationGO:00303361020.025
nucleoside triphosphate catabolic processGO:00091433940.024
rna export from nucleusGO:0006405330.024
osteoblast differentiationGO:0001649920.024
positive regulation of transferase activityGO:00513472270.024
cell developmentGO:00484683280.024
regulation of anatomical structure morphogenesisGO:00226032860.024
negative regulation of cellular component movementGO:00512711060.024
positive regulation of programmed cell deathGO:00430682490.024
cell divisionGO:00513011680.024
positive regulation of dna metabolic processGO:0051054730.023
coenzyme metabolic processGO:0006732650.023
immune system developmentGO:00025201950.023
positive regulation of cell differentiationGO:00455972110.023
response to biotic stimulusGO:00096072760.023
immune effector processGO:00022521590.023
cation transportGO:00068123310.023
positive regulation of interferon gamma productionGO:0032729260.023
mitotic cell cycle processGO:19030472860.023
negative regulation of programmed cell deathGO:00430693210.023
negative regulation of cell deathGO:00605483450.022
negative regulation of locomotionGO:00400131180.022
regulation of kinase activityGO:00435493140.022
regulation of cell cycle processGO:00105642660.022
nucleobase containing compound transportGO:0015931510.022
purine ribonucleoside triphosphate catabolic processGO:00092073910.022
positive regulation of nucleoside metabolic processGO:00459791860.022
myeloid cell differentiationGO:00300991170.021
regulation of nucleotide metabolic processGO:00061402690.021
protein localization to nucleusGO:00345041360.021
cellular carbohydrate metabolic processGO:0044262840.021
protein oligomerizationGO:00512591730.021
positive regulation of cell proliferationGO:00082843010.021
response to virusGO:00096151260.021
nucleic acid transportGO:0050657390.021
ossificationGO:00015031210.020
reproductionGO:0000003630.020
cellular response to cytokine stimulusGO:00713451810.020
purine nucleoside monophosphate catabolic processGO:00091281580.019
regulation of endopeptidase activityGO:00525481700.019
embryo developmentGO:00097901230.019
regulation of nucleotide catabolic processGO:00308112050.019
hexose metabolic processGO:0019318550.019
maintenance of locationGO:00512351120.019
negative regulation of cell differentiationGO:00455961710.019
positive regulation of purine nucleotide metabolic processGO:19005442270.019
posttranscriptional regulation of gene expressionGO:00106082130.019
negative regulation of hydrolase activityGO:00513461820.019
enzyme linked receptor protein signaling pathwayGO:00071673030.018
single organism nuclear importGO:19025931040.018
regulation of nucleocytoplasmic transportGO:0046822980.018
regulation of purine nucleotide metabolic processGO:19005422640.018
protein localization to organelleGO:00333652800.018
nervous system developmentGO:00073992930.018
lipid biosynthetic processGO:00086101770.018
epithelial cell differentiationGO:00308551410.018
response to bacteriumGO:00096171440.018
nucleocytoplasmic transportGO:00069131760.018
positive regulation of catabolic processGO:00098963100.018
regulation of cellular carbohydrate metabolic processGO:0010675470.017
purine nucleotide catabolic processGO:00061954050.017
cellular lipid metabolic processGO:00442553030.017
negative regulation of phosphorus metabolic processGO:00105632670.017
one carbon metabolic processGO:000673010.017
regulation of cellular component biogenesisGO:00440872810.017
mapk cascadeGO:00001652880.017
regulation of proteolysisGO:00301622930.017
negative regulation of apoptotic processGO:00430663160.017
regulation of cytoplasmic transportGO:19036491490.017
single organism cell adhesionGO:00986021790.017
regulation of protein serine threonine kinase activityGO:00719001790.017
pigment biosynthetic processGO:0046148100.017
angiogenesisGO:00015251470.017
regulation of peptidase activityGO:00525471800.017
positive regulation of endopeptidase activityGO:0010950840.016
trna metabolic processGO:0006399350.016
cell activationGO:00017752130.016
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.016
nuclear exportGO:0051168690.016
protein ubiquitinationGO:00165673140.016
cellular amine metabolic processGO:0044106410.016
hormone secretionGO:0046879650.016
ribonucleoside monophosphate metabolic processGO:00091611870.016
cofactor metabolic processGO:0051186870.016
protein maturationGO:00516042330.016
mitotic cell cycleGO:00002783260.016
response to abiotic stimulusGO:00096283360.016
positive regulation of purine nucleotide catabolic processGO:00331231850.016
organelle fissionGO:00482851490.016
oogenesisGO:004847720.016
positive regulation of cytokine productionGO:00018191670.016
response to extracellular stimulusGO:0009991850.016
reactive oxygen species metabolic processGO:0072593750.016
intracellular protein transportGO:00068862700.015
carbohydrate derivative biosynthetic processGO:19011372070.015
response to other organismGO:00517072610.015
response to axon injuryGO:004867810.015
positive regulation of developmental processGO:00510943140.015
generation of neuronsGO:00486991520.015
positive regulation of apoptotic processGO:00430652460.015
regulation of cell cycleGO:00517263930.015
secretionGO:00469032540.015
cellular protein catabolic processGO:00442572610.015
response to lipidGO:00339932060.015
regulation of cytoskeleton organizationGO:00514931770.015
ribonucleotide catabolic processGO:00092614050.015
regulation of protein kinase activityGO:00458592890.015
negative regulation of cell proliferationGO:00082852280.014
cellular response to biotic stimulusGO:0071216710.014
response to molecule of bacterial originGO:0002237820.014
regulation of response to dna damage stimulusGO:2001020940.014
negative regulation of cell motilityGO:20001461040.014
vesicle mediated transportGO:00161923710.014
monosaccharide metabolic processGO:0005996740.014
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.014
positive regulation of cellular amine metabolic processGO:003324070.014
cation transmembrane transportGO:00986552380.014
single organism membrane organizationGO:00448022680.014
cell part morphogenesisGO:00329901370.014
leukocyte mediated cytotoxicityGO:0001909270.014
chemical homeostasisGO:00488783060.014
single organism reproductive processGO:0044702980.014
ion transmembrane transportGO:00342203380.014
rna transportGO:0050658390.014
locomotory behaviorGO:000762610.014
rho protein signal transductionGO:0007266260.014
protein foldingGO:0006457380.013
cellular response to hormone stimulusGO:00328701250.013
mitochondrial translationGO:0032543170.013
regulation of mapk cascadeGO:00434082620.013
anatomical structure formation involved in morphogenesisGO:00486462840.013
cellular response to nitrogen compoundGO:19016991440.013
sulfur compound metabolic processGO:00067901010.013
regulation of response to external stimulusGO:00321012220.013
regulation of cytokine productionGO:00018172320.013
positive regulation of protein transportGO:00512221350.013
regulation of protein complex assemblyGO:00432541470.013
response to inorganic substanceGO:00100351270.013
response to peptide hormoneGO:0043434610.013
positive regulation of kinase activityGO:00336742040.013
nucleoside phosphate catabolic processGO:19012924120.013
segmentationGO:003528240.013
regulation of sequence specific dna binding transcription factor activityGO:00510902110.013
regulation of cellular ketone metabolic processGO:0010565500.013
sensory perception of painGO:001923340.013
cellular response to organonitrogen compoundGO:00714171240.013
cellular response to lipidGO:00713961270.013
ribonucleoside monophosphate catabolic processGO:00091581580.013
regulation of cellular amine metabolic processGO:0033238110.013
positive regulation of nucleotide catabolic processGO:00308131850.013
trna transportGO:005103110.013
positive regulation of proteolysisGO:00458621420.012
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.012
cellular ion homeostasisGO:00068731680.012
blood vessel developmentGO:00015681720.012
negative regulation of phosphorylationGO:00423261740.012
oocyte developmentGO:004859910.012
alpha amino acid biosynthetic processGO:1901607230.012
microtubule based processGO:00070172100.012
cellular response to external stimulusGO:00714961110.012
negative regulation of protein modification processGO:00314002000.012
mitotic nuclear divisionGO:00070671190.012
protein tetramerizationGO:0051262470.012
positive regulation of secretion by cellGO:19035321080.012
nuclear importGO:00511701060.012
nucleobase biosynthetic processGO:004611240.012
system processGO:00030083490.012
positive regulation of cellular component biogenesisGO:00440891580.012
regulation of cell divisionGO:00513021160.012
cellular chemical homeostasisGO:00550821800.012
ribonucleoprotein complex localizationGO:007116640.012
erythrocyte homeostasisGO:0034101310.012
protein modification by small protein conjugationGO:00324463420.012
purine ribonucleoside monophosphate metabolic processGO:00091671860.012
protein import into nucleusGO:00066061040.012
regulation of protein import into nucleusGO:0042306780.012
rna localizationGO:0006403410.012
dephosphorylationGO:00163112090.011
muscle structure developmentGO:0061061980.011
purine ribonucleoside monophosphate catabolic processGO:00091691580.011
lipid metabolic processGO:00066293810.011
response to hormoneGO:00097251750.011
protein importGO:00170381300.011
central nervous system developmentGO:00074171230.011
negative regulation of developmental processGO:00510932470.011
regulation of map kinase activityGO:00434051080.011
regulation of vasculature developmentGO:1901342970.011
neurological system processGO:00508771630.011
regulation of protein bindingGO:0043393660.011
regulation of bindingGO:00510981110.011
leukocyte activationGO:00453211640.011
response to radiationGO:00093141510.011
syncytium formation by plasma membrane fusionGO:000076820.011
positive regulation of protein kinase activityGO:00458601900.011
compound eye developmentGO:004874910.011
lymphocyte activationGO:00466491330.011
cellular response to molecule of bacterial originGO:0071219620.011
regulation of cell morphogenesis involved in differentiationGO:0010769830.011
positive regulation of phosphorylationGO:00423273940.010
cell morphogenesisGO:00009022960.010
glucose metabolic processGO:0006006450.010
cytokine productionGO:00018162470.010
organic acid transportGO:0015849650.010
neuron differentiationGO:00301821380.010
wound healingGO:00420601150.010
spermatid developmentGO:000728640.010
positive regulation of gtpase activityGO:00435471660.010
cardiac muscle cell contractionGO:008600340.010
epithelium developmentGO:00604292270.010
regulation of protein catabolic processGO:00421761550.010
regulation of dna repairGO:0006282470.010

MTHFD2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
neuropathyDOID:870520.088
nervous system diseaseDOID:8634310.088
disease of metabolismDOID:00146672950.069
inherited metabolic disorderDOID:6552420.069
central nervous system diseaseDOID:3311860.059
organ system cancerDOID:00506861640.015
cancerDOID:1621670.015
disease of cellular proliferationDOID:145661740.015
neurodegenerative diseaseDOID:12891020.013
motor neuron diseaseDOID:231270.013
motor neuritisDOID:68350.013
charcot marie tooth diseaseDOID:10595330.011
neuromuscular diseaseDOID:440380.011