Homo sapiens

88 known processes

MAP2K2

mitogen-activated protein kinase kinase 2

(Aliases: FLJ26075,MAPKK2,MKK2,PRKMK2,MEK2)

MAP2K2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of cellular amine metabolic processGO:003324070.484
multicellular organismal agingGO:001025930.409
Worm
purine ribonucleotide catabolic processGO:00091544040.397
ras protein signal transductionGO:0007265730.315
Worm Fly
amine metabolic processGO:0009308440.293
cellular amine metabolic processGO:0044106410.289
positive regulation of cellular amino acid metabolic processGO:004576430.281
enzyme linked receptor protein signaling pathwayGO:00071673030.279
regulation of transferase activityGO:00513383550.240
regulation of response to external stimulusGO:00321012220.234
positive regulation of protein phosphorylationGO:00019343130.234
regulation of cellular amine metabolic processGO:0033238110.229
gtp catabolic processGO:00061842370.202
regulation of ras protein signal transductionGO:00465781550.188
Fly
positive regulation of protein kinase activityGO:00458601900.187
post embryonic developmentGO:000979120.176
Worm
guanosine containing compound catabolic processGO:19010692390.174
cellular amino acid metabolic processGO:00065201160.173
determination of adult lifespanGO:000834020.173
Worm
regulation of cellular component biogenesisGO:00440872810.167
actin filament based processGO:00300292240.159
Yeast
positive regulation of phosphorylationGO:00423273940.157
regulation of cellular ketone metabolic processGO:0010565500.156
regulation of protein kinase activityGO:00458592890.147
positive regulation of transferase activityGO:00513472270.146
small gtpase mediated signal transductionGO:0007264780.144
Worm Fly
protein catabolic processGO:00301633250.136
Worm
negative regulation of protein metabolic processGO:00512483910.128
single organism cellular localizationGO:19025803320.120
Yeast
positive regulation of kinase activityGO:00336742040.117
ribonucleoside triphosphate metabolic processGO:00091994120.109
cellular ketone metabolic processGO:0042180800.107
ribonucleoside triphosphate catabolic processGO:00092033910.106
purine nucleotide catabolic processGO:00061954050.104
regulation of kinase activityGO:00435493140.098
purine nucleoside triphosphate catabolic processGO:00091463920.096
regulation of proteolysisGO:00301622930.092
macroautophagyGO:0016236390.092
cellular protein catabolic processGO:00442572610.086
ribonucleotide catabolic processGO:00092614050.086
regulation of cell cycleGO:00517263930.085
Human
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.083
modification dependent macromolecule catabolic processGO:00436322120.082
negative regulation of cell proliferationGO:00082852280.082
Human
activation of protein kinase activityGO:0032147900.080
vesicle mediated transportGO:00161923710.079
regulation of mapk cascadeGO:00434082620.078
secretionGO:00469032540.078
glycosyl compound catabolic processGO:19016584130.077
ribonucleoside catabolic processGO:00424544060.076
response to nutrient levelsGO:0031667810.073
response to abiotic stimulusGO:00096283360.073
Yeast
signal transduction by phosphorylationGO:00230142970.072
proteasomal protein catabolic processGO:00104981760.072
system processGO:00030083490.070
positive regulation of erk1 and erk2 cascadeGO:0070374750.070
Fly
nucleotide catabolic processGO:00091664080.069
regulation of protein complex assemblyGO:00432541470.069
mitotic cell cycleGO:00002783260.068
transposition rna mediatedGO:003219700.067
Yeast
actin filament organizationGO:00070151280.067
Yeast
nucleoside triphosphate metabolic processGO:00091414220.067
regulation of bindingGO:00510981110.065
negative regulation of bindingGO:0051100570.065
positive regulation of developmental processGO:00510943140.065
nucleoside catabolic processGO:00091644080.063
actin cytoskeleton organizationGO:00300362070.063
Yeast
cellular macromolecule catabolic processGO:00442653800.062
negative regulation of catalytic activityGO:00430863350.062
negative regulation of apoptotic processGO:00430663160.062
purine nucleoside triphosphate metabolic processGO:00091444120.060
segmentationGO:003528240.059
Fly
cellular response to nutrient levelsGO:0031669690.059
regulation of cellular response to stressGO:00801352440.058
Yeast
purine nucleoside catabolic processGO:00061523980.057
purine ribonucleoside triphosphate metabolic processGO:00092054110.056
purine ribonucleoside catabolic processGO:00461303980.055
positive regulation of cell proliferationGO:00082843010.054
membrane organizationGO:00610242920.053
lipid metabolic processGO:00066293810.051
purine ribonucleoside metabolic processGO:00461284370.050
regulation of small gtpase mediated signal transductionGO:00510561560.050
Fly
positive regulation of cell differentiationGO:00455972110.050
cell cell signalingGO:00072671550.050
cellular response to external stimulusGO:00714961110.049
purine ribonucleoside triphosphate catabolic processGO:00092073910.049
proteolysis involved in cellular protein catabolic processGO:00516032440.049
regulation of purine nucleotide catabolic processGO:00331212050.049
negative regulation of cellular protein metabolic processGO:00322693530.048
positive regulation of mapk cascadeGO:00434101900.048
positive regulation of catabolic processGO:00098963100.048
neuron differentiationGO:00301821380.047
regulation of cellular amino acid metabolic processGO:000652160.046
mapk cascadeGO:00001652880.046
positive regulation of cell deathGO:00109422630.045
regulation of gtp catabolic processGO:00331241800.044
response to extracellular stimulusGO:0009991850.044
female gamete generationGO:000729220.044
Fly
negative regulation of cell deathGO:00605483450.043
regulation of cytoskeleton organizationGO:00514931770.043
protein autophosphorylationGO:00467771230.043
anatomical structure formation involved in morphogenesisGO:00486462840.042
cytoplasmic transportGO:00164823790.042
Yeast
nucleoside triphosphate catabolic processGO:00091433940.042
modification dependent protein catabolic processGO:00199412090.042
immune responseGO:00069553070.041
negative regulation of phosphate metabolic processGO:00459362670.041
negative regulation of programmed cell deathGO:00430693210.040
transmembrane transportGO:00550853990.040
cellular response to extracellular stimulusGO:0031668720.040
positive regulation of neurogenesisGO:0050769490.039
single organism membrane organizationGO:00448022680.038
tor signalingGO:0031929390.038
regulation of immune responseGO:00507762010.037
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.036
positive regulation of neuron differentiationGO:0045666400.036
regulation of protein serine threonine kinase activityGO:00719001790.035
regulation of growthGO:00400081650.035
embryo developmentGO:00097901230.035
Worm Fly
response to oxygen containing compoundGO:19017003690.035
regulation of mitotic cell cycleGO:00073461890.035
cell activationGO:00017752130.034
cardiovascular system developmentGO:00723582620.034
cell adhesionGO:00071553250.034
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.034
mitotic cell cycle processGO:19030472860.034
peptidyl tyrosine modificationGO:00182121700.034
peptidyl tyrosine phosphorylationGO:00181081700.033
regulation of multi organism processGO:00439001570.033
Yeast
cation transportGO:00068123310.033
digestive system developmentGO:0055123750.033
regulation of anatomical structure morphogenesisGO:00226032860.033
positive regulation of hydrolase activityGO:00513453310.032
anterior posterior axis specification embryoGO:000859520.032
Fly
anterior posterior axis specificationGO:000994820.032
Fly
positive regulation of programmed cell deathGO:00430682490.032
synaptic transmissionGO:0007268610.032
tube morphogenesisGO:0035239950.031
metal ion transportGO:00300012720.031
secretion by cellGO:00329402260.031
erk1 and erk2 cascadeGO:00703711040.031
Fly
regulation of nucleoside metabolic processGO:00091182090.031
symbiosis encompassing mutualism through parasitismGO:00444031560.031
ubiquitin dependent protein catabolic processGO:00065112060.031
wound healingGO:00420601150.031
growthGO:00400072020.031
Yeast
nervous system developmentGO:00073992930.031
endomembrane system organizationGO:00102561960.030
protein localization to plasma membraneGO:0072659930.030
positive regulation of cellular catabolic processGO:00313312840.030
negative regulation of phosphorus metabolic processGO:00105632670.029
regulation of neuron differentiationGO:0045664700.029
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.029
regulation of proteasomal protein catabolic processGO:0061136870.029
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.029
chemical homeostasisGO:00488783060.029
response to cytokineGO:00340972320.029
positive regulation of apoptotic processGO:00430652460.029
regulation of protein catabolic processGO:00421761550.029
epithelial cell migrationGO:00106311190.029
Fly
carbohydrate metabolic processGO:00059752070.028
positive regulation of small gtpase mediated signal transductionGO:0051057120.028
Fly
regulation of map kinase activityGO:00434051080.028
photoreceptor cell differentiationGO:004653020.028
regulation of protein localizationGO:00328802960.028
negative regulation of mitotic cell cycleGO:00459301020.028
cellular lipid metabolic processGO:00442553030.027
regulation of nucleotide catabolic processGO:00308112050.027
positive regulation of organelle organizationGO:00106381950.027
establishment of protein localization to organelleGO:00725941720.027
Yeast
organophosphate catabolic processGO:00464344300.027
regulation of autophagyGO:0010506520.027
response to growth factorGO:00708482050.027
cellular response to nitrogen compoundGO:19016991440.026
regulation of cell developmentGO:00602841610.026
histone modificationGO:00165702510.026
glycoprotein metabolic processGO:00091001100.026
g protein coupled receptor signaling pathwayGO:00071862070.026
Yeast
divalent inorganic cation transportGO:00725111580.026
positive regulation of nervous system developmentGO:0051962540.026
blastoderm segmentationGO:000735020.026
Fly
regulation of peptidyl serine phosphorylationGO:0033135500.026
organelle localizationGO:0051640840.026
negative regulation of macroautophagyGO:001624240.025
regulation of behaviorGO:0050795820.025
cell cycle phase transitionGO:00447701730.025
regulation of actin filament based processGO:00329701410.025
stem cell divisionGO:001714520.025
guanosine containing compound metabolic processGO:19010682440.024
oogenesisGO:004847720.024
Fly
regulation of protein bindingGO:0043393660.024
purine containing compound catabolic processGO:00725234110.024
negative regulation of cell cycleGO:00457861930.024
Human
negative regulation of catabolic processGO:00098951040.023
response to woundingGO:00096111680.023
mitotic cell cycle phase transitionGO:00447721620.023
tissue migrationGO:00901301190.023
Fly
regulation of nervous system developmentGO:0051960880.023
stress activated protein kinase signaling cascadeGO:0031098940.023
response to nitrogen compoundGO:19016981840.023
response to hormoneGO:00097251750.023
neuroblast divisionGO:005505710.023
peptidyl serine phosphorylationGO:00181051010.023
positive regulation of actin filament polymerizationGO:0030838380.023
regulation of tor signalingGO:0032006300.023
negative regulation of hydrolase activityGO:00513461820.022
muscle system processGO:0003012810.022
microtubule based processGO:00070172100.022
regulation of cell differentiationGO:00455953930.022
epithelium migrationGO:00901321190.022
Fly
gtp metabolic processGO:00460392390.022
canonical wnt signaling pathwayGO:00600701160.022
heart processGO:0003015620.022
positive regulation of peptidyl serine phosphorylationGO:0033138420.021
locomotory behaviorGO:000762610.021
cell morphogenesisGO:00009022960.021
response to calcium ionGO:0051592460.021
negative regulation of protein maturationGO:19033181420.021
head developmentGO:00603221080.021
cell type specific apoptotic processGO:00972851250.021
positive regulation of cellular component organizationGO:00511303760.021
oocyte developmentGO:004859910.021
regulation of actin cytoskeleton organizationGO:00329561160.021
cell divisionGO:00513011680.020
tube developmentGO:00352951250.020
positive regulation of cell developmentGO:0010720920.020
cytokine productionGO:00018162470.020
response to metal ionGO:0010038840.020
regulation of ras gtpase activityGO:00323181280.020
cellular chemical homeostasisGO:00550821800.020
response to inorganic substanceGO:00100351270.020
neurological system processGO:00508771630.020
regulation of cell activationGO:00508651250.020
regulation of gtpase activityGO:00430871800.020
stress activated mapk cascadeGO:0051403930.020
regulation of secretionGO:00510461940.020
regulation of cell cycle processGO:00105642660.020
cell fate commitmentGO:0045165270.020
cell developmentGO:00484683280.020
Fly
defense responseGO:00069523150.020
negative regulation of intracellular signal transductionGO:19025321830.019
cellular response to oxygen containing compoundGO:19017012760.019
regulation of protein maturationGO:19033171500.019
protein localization to membraneGO:00726571600.019
cellular component morphogenesisGO:00329893140.019
apoptotic signaling pathwayGO:00971902680.019
negative regulation of protein bindingGO:0032091350.019
divalent metal ion transportGO:00708381520.019
circadian behaviorGO:004851220.019
protein processingGO:00164852260.019
sensory perceptionGO:00076001030.019
regulation of anatomical structure sizeGO:00900661010.019
ion transmembrane transportGO:00342203380.019
epithelial cell proliferationGO:00506731280.019
hematopoietic or lymphoid organ developmentGO:00485341860.019
protein oligomerizationGO:00512591730.019
positive regulation of cell motilityGO:20001471770.019
Mouse
regulation of vesicle mediated transportGO:00606271300.018
hard palate developmentGO:006002210.018
single organism carbohydrate metabolic processGO:00447231930.018
peptidyl serine modificationGO:00182091060.018
regulation of cytokine productionGO:00018172320.018
neuroblast proliferationGO:000740540.018
regulation of protein processingGO:00706131500.018
brain developmentGO:0007420970.018
negative regulation of proteolysisGO:00458611320.018
positive regulation of purine nucleotide catabolic processGO:00331231850.018
immune effector processGO:00022521590.018
regulation of stress activated mapk cascadeGO:0032872840.018
regulation of locomotionGO:00400123290.018
Mouse
dephosphorylationGO:00163112090.018
regulation of sequence specific dna binding transcription factor activityGO:00510902110.018
cellular protein complex assemblyGO:00436231880.017
negative regulation of apoptotic signaling pathwayGO:2001234970.017
positive regulation of immune system processGO:00026842830.017
negative regulation of cellular catabolic processGO:0031330830.017
regulation of ion transportGO:00432691890.017
chromatin modificationGO:00165682980.017
regulation of stress activated protein kinase signaling cascadeGO:0070302850.017
negative regulation of protein processingGO:00109551420.017
vesicle organizationGO:0016050620.017
positive regulation of chemotaxisGO:0050921570.017
negative regulation of endopeptidase activityGO:0010951840.017
regulation of cellular protein catabolic processGO:1903362960.017
positive regulation of cellular component biogenesisGO:00440891580.017
nuclear transportGO:00511691790.017
Yeast
response to external biotic stimulusGO:00432072610.016
epithelial cell differentiationGO:00308551410.016
Fly
negative regulation of response to external stimulusGO:0032102830.016
response to organic cyclic compoundGO:00140702040.016
negative regulation of phosphorylationGO:00423261740.016
autophagyGO:0006914880.016
Yeast
regulation of system processGO:00440571010.016
carbohydrate derivative biosynthetic processGO:19011372070.016
neurogenesisGO:00220081690.016
negative regulation of peptidase activityGO:0010466910.016
internal protein amino acid acetylationGO:00064751010.016
immune system developmentGO:00025201950.016
erbb signaling pathwayGO:0038127440.016
nucleoside phosphate catabolic processGO:19012924120.016
regulation of erk1 and erk2 cascadeGO:0070372990.016
Fly
positive regulation of protein serine threonine kinase activityGO:00719021190.016
response to molecule of bacterial originGO:0002237820.016
cytokine mediated signaling pathwayGO:00192211090.015
regulation of peptidase activityGO:00525471800.015
central nervous system projection neuron axonogenesisGO:002195230.015
plasma membrane organizationGO:00070091150.015
protein localization to nucleusGO:00345041360.015
Yeast
regulation of nucleotide metabolic processGO:00061402690.015
protein secretionGO:0009306980.015
regulation of cell motilityGO:20001452990.015
Mouse
cellular response to endogenous stimulusGO:00714953360.015
lipid homeostasisGO:0055088390.015
cell fate determinationGO:000170930.015
protein kinase b signalingGO:0043491690.015
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.015
regulation of wnt signaling pathwayGO:00301111230.015
regulation of peptidyl tyrosine phosphorylationGO:00507301080.015
oocyte differentiationGO:000999420.015
calcium ion transportGO:00068161470.015
organelle assemblyGO:00709251760.014
hemopoiesisGO:00300971800.014
covalent chromatin modificationGO:00165692540.014
cation transmembrane transportGO:00986552380.014
jnk cascadeGO:0007254800.014
inorganic ion transmembrane transportGO:00986602310.014
response to lipopolysaccharideGO:0032496700.014
epithelium developmentGO:00604292270.014
Fly
axon cargo transportGO:000808820.014
embryo development ending in birth or egg hatchingGO:0009792340.014
Worm
positive regulation of ion transportGO:0043270870.014
regulation of endopeptidase activityGO:00525481700.014
positive regulation of protein complex assemblyGO:0031334860.014
purine nucleoside monophosphate catabolic processGO:00091281580.014
regulation of cysteine type endopeptidase activityGO:20001161270.014
behaviorGO:00076101120.014
cell cell junction organizationGO:0045216690.014
regulation of apoptotic signaling pathwayGO:20012331750.014
response to oxidative stressGO:00069791210.014
digestive tract developmentGO:0048565750.014
nucleocytoplasmic transportGO:00069131760.014
Yeast
regulation of transmembrane transportGO:00347621390.014
peptidyl lysine acetylationGO:00183941010.014
regulation of jnk cascadeGO:0046328730.014
regulation of endothelial cell proliferationGO:0001936560.014
negative regulation of immune system processGO:00026831360.014
innate immune responseGO:00450871780.014
regulation of actin filament lengthGO:0030832560.014
regulation of secretion by cellGO:19035301770.014
cell growthGO:00160491600.013
Yeast
immune response regulating signaling pathwayGO:0002764970.013
activation of immune responseGO:00022531140.013
organonitrogen compound biosynthetic processGO:19015662000.013
actin polymerization or depolymerizationGO:0008154560.013
response to fungusGO:000962040.013
protein importGO:00170381300.013
Yeast
response to oxygen levelsGO:00704821000.013
cellular response to metal ionGO:0071248430.013
endocytosisGO:00068971590.013
negative regulation of sequence specific dna binding transcription factor activityGO:0043433890.013
vasculature developmentGO:00019441810.013
negative regulation of cellular component organizationGO:00511292350.013
syncytium formation by plasma membrane fusionGO:000076820.013
negative regulation of kinase activityGO:00336731060.013
microtubule cytoskeleton organizationGO:00002261760.013
generation of neuronsGO:00486991520.013
lens development in camera type eyeGO:000208820.013
regionalizationGO:0003002290.013
Fly
nitrogen compound transportGO:00717051910.013
cellular response to transforming growth factor beta stimulusGO:0071560940.013
receptor metabolic processGO:0043112810.013
regulation of actin polymerization or depolymerizationGO:0008064560.013
organ morphogenesisGO:00098871470.013
organophosphate biosynthetic processGO:00904071630.013
leukocyte differentiationGO:0002521980.013
negative regulation of protein modification processGO:00314002000.013
positive regulation of mitotic cell cycleGO:0045931600.013
gastrulationGO:0007369510.012
negative regulation of transportGO:00510511760.012
cell projection morphogenesisGO:00488581290.012
osteoblast differentiationGO:0001649920.012
digestive tract morphogenesisGO:0048546560.012
reproductive system developmentGO:0061458560.012
Worm
blood vessel developmentGO:00015681720.012
regulation of purine nucleotide metabolic processGO:19005422640.012
negative regulation of transferase activityGO:00513481240.012
cellular response to growth factor stimulusGO:00713631970.012
developmental growthGO:0048589480.012
positive regulation of locomotionGO:00400171860.012
Mouse
cytokinesisGO:0000910960.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.012
response to interleukin 1GO:0070555470.012
cell chemotaxisGO:00603261120.012
chromatin organizationGO:00063253510.012
rho protein signal transductionGO:0007266260.012
regulation of cellular component movementGO:00512703340.012
Mouse
regulation of cell adhesionGO:00301551660.012
regulation of leukocyte chemotaxisGO:0002688460.012
multi organism cellular processGO:00447641560.012
Yeast
nuclear importGO:00511701060.012
Yeast
regulation of epithelial cell proliferationGO:00506781130.012
cellular response to cytokine stimulusGO:00713451810.012
positive regulation of cytoskeleton organizationGO:0051495830.012
positive regulation of transportGO:00510503360.011
viral processGO:00160321460.011
cellular response to starvationGO:0009267580.011
protein localization to organelleGO:00333652800.011
Yeast
cellular macromolecular complex assemblyGO:00346223240.011
biological adhesionGO:00226103310.011
sulfur compound metabolic processGO:00067901010.011
receptor mediated endocytosisGO:0006898840.011
monocarboxylic acid metabolic processGO:00327871850.011
response to other organismGO:00517072610.011
cellular response to inorganic substanceGO:0071241450.011
cell substrate adhesionGO:00315891320.011
positive regulation of gtpase activityGO:00435471660.011
regulation of response to extracellular stimulusGO:0032104220.011
regulation of ion transmembrane transportGO:00347651320.011
atp metabolic processGO:00460341760.011
response to starvationGO:0042594590.011
endosomal transportGO:00161971290.011
protein homooligomerizationGO:00512601000.011
reproductive processGO:00224141060.011
Yeast Worm Fly
regulation of establishment of protein localizationGO:00702012420.011
rhythmic behaviorGO:000762220.011
regulation of response to woundingGO:19030341010.011
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043154460.011
response to hypoxiaGO:0001666960.011
regulation of protein modification by small protein conjugation or removalGO:19033201070.011
endothelial cell proliferationGO:0001935650.011
endothelial cell migrationGO:0043542860.011
agingGO:0007568660.011
Human Worm
response to lipidGO:00339932060.011
positive regulation of cell sizeGO:004579330.011
sensory perception of smellGO:000760820.011
embryonic morphogenesisGO:0048598850.011
neuron deathGO:0070997650.011
response to purine containing compoundGO:0014074400.010
protein targetingGO:00066051870.010
Yeast
positive regulation of purine nucleotide metabolic processGO:19005442270.010
mononuclear cell proliferationGO:0032943710.010
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.010
regulation of phosphatase activityGO:0010921810.010
regulation of response to nutrient levelsGO:0032107220.010
epidermal growth factor receptor signaling pathwayGO:0007173390.010
regulation of defense responseGO:00313471540.010
regulation of protein kinase b signalingGO:0051896610.010
calcium ion transmembrane transportGO:0070588760.010
response to decreased oxygen levelsGO:0036293960.010
compound eye developmentGO:004874910.010
protein maturationGO:00516042330.010

MAP2K2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.038
cancerDOID:1621670.030
organ system cancerDOID:00506861640.022
muscular diseaseDOID:00800001140.011
myopathyDOID:4231040.011
muscle tissue diseaseDOID:661130.011
musculoskeletal system diseaseDOID:172230.011
endocrine gland cancerDOID:170260.011
nervous system diseaseDOID:8634310.010
central nervous system diseaseDOID:3311860.010