Homo sapiens

31 known processes

HLA-DRA

major histocompatibility complex, class II, DR alpha

(Aliases: MLRW,FLJ51114,HLA-DRA1)

HLA-DRA biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dendritic cell antigen processing and presentationGO:000246811.000
peptide antigen assembly with mhc protein complexGO:000250141.000
antigen processing and presentation of peptide antigen via mhc class iiGO:0002495111.000
negative regulation of antigen processing and presentationGO:000257851.000
Human
peptide antigen assembly with mhc class ii protein complexGO:000250341.000
positive regulation of myeloid leukocyte cytokine production involved in immune responseGO:006108111.000
inflammatory response to antigenic stimulusGO:000243741.000
antigen processing and presentation of peptide antigenGO:0048002181.000
antigen processing and presentationGO:0019882331.000
antigen processing and presentation of peptide or polysaccharide antigen via mhc class iiGO:0002504120.999
mhc protein complex assemblyGO:000239640.998
de novo protein foldingGO:000645820.997
antigen processing and presentation of polysaccharide antigen via mhc class iiGO:000250520.997
regulation of interleukin 10 secretionGO:200117940.994
antigen processing and presentation of exogenous peptide antigen via mhc class iiGO:001988640.994
antigen processing and presentation of exogenous peptide antigenGO:000247840.993
regulation of t cell proliferationGO:0042129420.987
lymphocyte proliferationGO:0046651700.968
t cell proliferationGO:0042098450.967
positive regulation of lymphocyte proliferationGO:0050671460.965
cytokine productionGO:00018162470.961
regulation of cytokine productionGO:00018172320.960
positive regulation of mononuclear cell proliferationGO:0032946470.954
polysaccharide assembly with mhc class ii protein complexGO:000250620.946
peptide secretionGO:0002790510.945
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via mhc class iiGO:000258130.941
Human
cellular protein complex assemblyGO:00436231880.941
mononuclear cell proliferationGO:0032943710.937
regulation of lymphocyte proliferationGO:0050670640.933
negative regulation of antigen processing and presentation of peptide antigenGO:000258430.922
Human
cell activationGO:00017752130.920
humoral immune responseGO:0006959490.918
protein carbohydrate complex assemblyGO:006500620.915
regulation of leukocyte proliferationGO:0070663670.898
positive regulation of cell activationGO:0050867810.896
adaptive immune responseGO:0002250490.892
detection of biotic stimulusGO:0009595210.892
regulation of mononuclear cell proliferationGO:0032944650.887
protein tetramerizationGO:0051262470.882
positive regulation of lymphocyte differentiationGO:0045621130.861
positive regulation of immune system processGO:00026842830.846
antigen processing and presentation of exogenous antigenGO:001988440.840
t cell selectionGO:004505840.833
positive regulation of lymphocyte activationGO:0051251730.831
t cell activationGO:0042110990.817
peptide transportGO:0015833740.815
negative regulation of antigen processing and presentation of peptide antigen via mhc class iiGO:000258720.813
Human
t helper 1 type immune responseGO:004208880.809
regulation of cell activationGO:00508651250.807
peptide hormone secretionGO:0030072500.807
immune responseGO:00069553070.799
lymphocyte mediated immunityGO:0002449480.798
regulation of leukocyte activationGO:00026941150.782
interferon gamma productionGO:0032609390.776
regulation of t cell activationGO:0050863770.776
positive regulation of leukocyte activationGO:0002696800.775
cellular response to interferon gammaGO:0071346240.762
negative regulation of immune system processGO:00026831360.756
Human
regulation of lymphocyte activationGO:00512491030.738
leukocyte activationGO:00453211640.735
positive thymic t cell selectionGO:004505910.734
positive regulation of immune responseGO:00507781590.730
lymphocyte activationGO:00466491330.730
regulation of interferon gamma productionGO:0032649360.729
positive regulation of t cell proliferationGO:0042102330.729
positive regulation of cell proliferationGO:00082843010.727
nitrogen compound transportGO:00717051910.712
leukocyte proliferationGO:0070661740.711
cellular macromolecular complex assemblyGO:00346223240.711
positive regulation of leukocyte proliferationGO:0070665480.705
leukocyte mediated immunityGO:0002443590.701
myeloid leukocyte cytokine productionGO:006108250.687
positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:003577430.681
interleukin 10 productionGO:0032613170.678
negative regulation of defense responseGO:0031348470.671
positive regulation of t helper 1 type immune responseGO:000282740.666
regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cellGO:200118820.645
positive regulation of insulin secretionGO:0032024100.641
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824190.634
negative regulation of cell proliferationGO:00082852280.626
response to hexoseGO:0009746200.622
positive regulation of t cell differentiationGO:0045582110.618
immune effector processGO:00022521590.608
positive regulation of transportGO:00510503360.605
detection of external biotic stimulusGO:0098581190.587
secretionGO:00469032540.579
b cell homeostasisGO:000178210.564
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002460400.563
cellular homeostasisGO:00197251960.562
cellular lipid metabolic processGO:00442553030.558
positive regulation of developmental processGO:00510943140.541
cellular response to ammonium ionGO:007124240.541
immunoglobulin mediated immune responseGO:0016064100.533
regulation of behaviorGO:0050795820.522
response to bacteriumGO:00096171440.513
negative regulation of t cell activationGO:0050868180.505
regulation of defense responseGO:00313471540.503
positive regulation of t cell activationGO:0050870540.493
type 2 immune responseGO:004209260.491
innate immune responseGO:00450871780.490
defense responseGO:00069523150.475
positive regulation of hormone secretionGO:0046887250.470
regulation of cytokine secretionGO:0050707570.447
detection of chemical stimulus involved in sensory perceptionGO:0050907330.446
humoral immune response mediated by circulating immunoglobulinGO:000245550.444
cytokine secretionGO:0050663640.443
regulation of antigen processing and presentation of peptide antigen via mhc class iiGO:000258630.430
Human
hematopoietic or lymphoid organ developmentGO:00485341860.429
hemopoiesisGO:00300971800.410
b cell mediated immunityGO:0019724100.409
de novo posttranslational protein foldingGO:005108420.402
regulation of response to woundingGO:19030341010.388
regulation of lymphocyte differentiationGO:0045619220.385
negative regulation of mononuclear cell proliferationGO:0032945150.385
regulation of adaptive immune responseGO:0002819330.380
immune system developmentGO:00025201950.374
regulation of response to dna damage stimulusGO:2001020940.371
hormone transportGO:0009914680.349
hormone secretionGO:0046879650.349
positive regulation of peptide secretionGO:0002793150.337
chaperone mediated protein foldingGO:0061077130.328
inflammatory responseGO:0006954790.326
protein secretionGO:0009306980.321
response to cytokineGO:00340972320.318
regulation of response to external stimulusGO:00321012220.317
negative regulation of response to external stimulusGO:0032102830.316
negative regulation of cell activationGO:0050866330.314
cellular chemical homeostasisGO:00550821800.308
secretion by cellGO:00329402260.301
cellular response to oxygen containing compoundGO:19017012760.290
regulation of immune responseGO:00507762010.281
regulation of hormone secretionGO:0046883570.279
interleukin 10 secretionGO:007260850.266
mhc class ii protein complex assemblyGO:000239940.266
positive regulation of secretionGO:00510471160.264
regulation of peptide secretionGO:0002791420.260
positive regulation of adaptive immune responseGO:0002821210.260
regulation of cell migrationGO:00303342890.257
protein carbohydrate complex subunit organizationGO:007182320.250
positive regulation of cellular amine metabolic processGO:003324070.247
system processGO:00030083490.238
chemokine c x c motif ligand 2 productionGO:007256730.226
positive regulation of peptide hormone secretionGO:0090277150.225
unsaturated fatty acid metabolic processGO:0033559370.222
positive regulation of humoral immune responseGO:000292230.209
chaperone mediated protein folding requiring cofactorGO:005108510.207
negative regulation of b cell apoptotic processGO:000290340.207
cellular glucose homeostasisGO:0001678110.206
regulation of leukocyte differentiationGO:1902105610.204
interleukin 4 productionGO:003263370.195
icosanoid metabolic processGO:0006690350.189
positive regulation of leukocyte differentiationGO:1902107370.184
regulation of cellular ketone metabolic processGO:0010565500.180
positive t cell selectionGO:004336820.176
cellular amine metabolic processGO:0044106410.174
fatty acid derivative metabolic processGO:1901568350.173
positive regulation of protein kinase activityGO:00458601900.171
regulation of secretionGO:00510461940.169
cellular response to glucose stimulusGO:0071333100.165
response to oxygen containing compoundGO:19017003690.165
t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cellGO:000229140.164
signal releaseGO:0023061700.163
cellular response to molecule of bacterial originGO:0071219620.155
regulation of protein processingGO:00706131500.151
negative regulation of lymphocyte activationGO:0051250240.148
negative regulation of transportGO:00510511760.145
regulation of neutrophil migrationGO:1902622100.144
cellular response to cytokine stimulusGO:00713451810.142
regulation of inflammatory response to antigenic stimulusGO:000286120.141
protein maturationGO:00516042330.130
cytokine production involved in immune responseGO:0002367270.128
regulation of interleukin 4 productionGO:003267370.126
negative regulation of immune responseGO:0050777400.123
negative regulation of peptidase activityGO:0010466910.123
regulation of macrophage cytokine productionGO:001093540.122
glucose homeostasisGO:0042593310.121
protein oligomerizationGO:00512591730.121
regulation of cellular response to stressGO:00801352440.120
cellular response to carbohydrate stimulusGO:0071322110.119
cytokine mediated signaling pathwayGO:00192211090.119
regulation of chemotaxisGO:0050920740.116
negative regulation of multicellular organismal processGO:00512413170.113
neurological system processGO:00508771630.111
regulation of apoptotic signaling pathwayGO:20012331750.111
detection of stimulusGO:0051606850.109
cellular amino acid metabolic processGO:00065201160.107
response to glucoseGO:0009749190.103
thymic t cell selectionGO:004506120.103
negative regulation of leukocyte activationGO:0002695260.102
negative regulation of response to woundingGO:1903035470.101
regulation of protein secretionGO:0050708860.100
regulation of peptide transportGO:0090087620.094
regulation of protein transportGO:00512232130.094
positive regulation of cytokine productionGO:00018191670.090
positive regulation of cellular amino acid metabolic processGO:004576430.086
t cell differentiationGO:0030217290.086
taxisGO:00423301570.086
regulation of interleukin 10 productionGO:0032653160.085
positive regulation of response to external stimulusGO:0032103880.084
negative regulation of interferon gamma productionGO:003268990.084
monocarboxylic acid biosynthetic processGO:0072330670.082
regulation of protein localizationGO:00328802960.079
positive regulation of cell migrationGO:00303351720.077
negative regulation of hydrolase activityGO:00513461820.077
fatty acid derivative biosynthetic processGO:1901570180.076
response to external biotic stimulusGO:00432072610.075
negative regulation of t cell proliferationGO:004213080.074
negative regulation of inflammatory response to antigenic stimulusGO:000286220.073
positive regulation of locomotionGO:00400171860.072
negative regulation of catalytic activityGO:00430863350.071
negative regulation of cell differentiationGO:00455961710.069
positive regulation of cellular component movementGO:00512721810.068
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822290.067
chemical homeostasisGO:00488783060.067
regulation of peptide hormone secretionGO:0090276410.066
negative regulation of homeostatic processGO:0032845590.064
regulation of leukocyte chemotaxisGO:0002688460.062
cell projection organizationGO:00300302520.059
t cell differentiation in thymusGO:003307740.058
cellular response to thyroid hormone stimulusGO:009706790.057
immunoglobulin productionGO:0002377120.057
cation transportGO:00068123310.057
endocytosisGO:00068971590.056
production of molecular mediator of immune responseGO:0002440370.055
response to monosaccharideGO:0034284200.055
negative regulation of chemotaxisGO:0050922130.053
negative regulation of blood vessel morphogenesisGO:2000181410.050
cell type specific apoptotic processGO:00972851250.049
detection of other organismGO:0098543130.049
amine metabolic processGO:0009308440.048
regulation of secretion by cellGO:19035301770.048
response to interferon gammaGO:0034341390.046
regulation of interleukin 12 productionGO:0032655150.046
positive regulation of interferon gamma productionGO:0032729260.045
positive regulation of behaviorGO:0048520600.045
negative regulation of cell deathGO:00605483450.044
negative regulation of cellular component organizationGO:00511292350.043
response to biotic stimulusGO:00096072760.042
motor neuron axon guidanceGO:000804520.041
positive regulation of kinase activityGO:00336742040.041
carbohydrate homeostasisGO:0033500310.041
post embryonic developmentGO:000979120.040
sprouting angiogenesisGO:0002040290.040
regulation of kinase activityGO:00435493140.039
unsaturated fatty acid biosynthetic processGO:0006636210.038
leukocyte activation involved in immune responseGO:0002366300.038
positive regulation of secretion by cellGO:19035321080.038
regulation of positive chemotaxisGO:0050926140.037
regulation of cell developmentGO:00602841610.036
negative regulation of programmed cell deathGO:00430693210.036
regulation of proteolysisGO:00301622930.036
negative regulation of apoptotic processGO:00430663160.035
peptidyl tyrosine phosphorylationGO:00181081700.035
negative regulation of leukocyte apoptotic processGO:2000107160.034
regulation of establishment of protein localizationGO:00702012420.034
response to fungusGO:000962040.034
azole transportGO:004511740.034
positive regulation of cell deathGO:00109422630.034
signal transduction in response to dna damageGO:0042770570.034
regulation of complement activation lectin pathwayGO:000186820.033
regulation of cell motilityGO:20001452990.033
cellular cation homeostasisGO:00300031630.032
regulation of cellular amino acid metabolic processGO:000652160.031
negative regulation of neuron projection developmentGO:0010977150.031
regulation of anatomical structure morphogenesisGO:00226032860.031
chemokine c c motif ligand 21 signaling pathwayGO:003811610.031
response to corticosteroidGO:0031960150.030
negative regulation of endopeptidase activityGO:0010951840.030
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332370.030
immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238150.029
granulocyte migrationGO:0097530400.028
regulation of neutrophil chemotaxisGO:0090022100.028
positive regulation of cytokine production involved in immune responseGO:000272060.028
lymphocyte homeostasisGO:000226040.028
cell developmentGO:00484683280.028
negative regulation of apoptotic signaling pathwayGO:2001234970.028
generation of neuronsGO:00486991520.028
regulation of immune effector processGO:0002697910.027
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555440.027
regulation of cell differentiationGO:00455953930.027
mapk cascadeGO:00001652880.027
response to molecule of bacterial originGO:0002237820.026
amide transportGO:0042886760.026
chemotaxisGO:00069351570.026
monocarboxylic acid metabolic processGO:00327871850.026
negative regulation of granulocyte chemotaxisGO:007162320.026
negative regulation of cellular protein metabolic processGO:00322693530.025
cellular response to oxidative stressGO:0034599850.025
negative regulation of intracellular signal transductionGO:19025321830.025
intrinsic apoptotic signaling pathwayGO:00971931270.025
positive regulation of chemokine productionGO:0032722220.024
tissue morphogenesisGO:0048729960.024
prostaglandin biosynthetic processGO:0001516110.024
astrocyte chemotaxisGO:003570010.024
negative regulation of secretionGO:0051048580.024
regulation of t cell differentiationGO:0045580190.023
regulation of insulin secretionGO:0050796330.023
regulation of homeostatic processGO:00328441210.023
cellular ketone metabolic processGO:0042180800.023
granulocyte chemotaxisGO:0071621370.023
regulation of cellular amine metabolic processGO:0033238110.022
positive regulation of ion transportGO:0043270870.022
negative regulation of leukocyte proliferationGO:0070664160.022
detection of bacteriumGO:0016045130.022
regulation of cell projection organizationGO:00313441070.022
ameboidal type cell migrationGO:00016671350.022
cellular response to dna damage stimulusGO:00069743790.021
negative regulation of inflammatory responseGO:0050728220.021
positive regulation of homeostatic processGO:0032846470.021
regulation of b cell proliferationGO:0030888180.021
cation homeostasisGO:00550801890.021
protein modification by small protein removalGO:0070646920.020
response to carbohydrateGO:0009743210.020
insulin secretion involved in cellular response to glucose stimulusGO:003577370.020
posttranscriptional regulation of gene expressionGO:00106082130.020
regulation of insulin secretion involved in cellular response to glucose stimulusGO:006117870.020
biological adhesionGO:00226103310.020
regenerationGO:003109940.020
regulation of mapk cascadeGO:00434082620.020
receptor metabolic processGO:0043112810.020
regulation of transferase activityGO:00513383550.019
negative regulation of neutrophil chemotaxisGO:009002420.019
organic acid biosynthetic processGO:0016053970.019
response to organic cyclic compoundGO:00140702040.019
negative regulation of cell developmentGO:0010721480.019
leukocyte chemotaxisGO:0030595760.019
dna damage response signal transduction by p53 class mediatorGO:0030330440.019
signal transduction by phosphorylationGO:00230142970.019
multicellular organismal agingGO:001025930.019
positive regulation of fibroblast proliferationGO:0048146210.019
positive regulation of cell motilityGO:20001471770.019
activation of protein kinase activityGO:0032147900.019
nervous system developmentGO:00073992930.018
organelle assemblyGO:00709251760.018
positive regulation of phosphorylationGO:00423273940.018
regulation of peptidase activityGO:00525471800.018
lymphocyte differentiationGO:0030098350.018
cellular response to hexose stimulusGO:0071331100.018
blood vessel morphogenesisGO:00485141620.017
regulation of neurogenesisGO:0050767820.017
regulation of hormone levelsGO:00108171250.017
regulation of inflammatory responseGO:0050727460.017
cognitionGO:0050890430.017
regulation of cytokine production involved in immune responseGO:0002718220.017
regulation of locomotionGO:00400123290.017
cellular response to glucocorticoid stimulusGO:007138540.017
inositol lipid mediated signalingGO:0048017550.017
negative regulation of lymphocyte proliferationGO:0050672150.016
positive regulation of transferase activityGO:00513472270.016
muscle system processGO:0003012810.016
immune response inhibiting signal transductionGO:000276540.016
positive regulation of protein serine threonine kinase activityGO:00719021190.016
positive regulation of erk1 and erk2 cascadeGO:0070374750.016
erk1 and erk2 cascadeGO:00703711040.016
small molecule biosynthetic processGO:00442831570.015
cellular response to monosaccharide stimulusGO:0071326100.015
chemokine productionGO:0032602320.015
negative regulation of cytokine productionGO:0001818820.015
fibroblast proliferationGO:0048144330.015
leukocyte apoptotic processGO:0071887310.015
positive regulation of neutrophil chemotaxisGO:009002370.015
insulin secretionGO:0030073390.015
proteolysis involved in cellular protein catabolic processGO:00516032440.015
patterning of blood vesselsGO:000156920.015
regulation of camp metabolic processGO:0030814520.015
protein processingGO:00164852260.015
positive chemotaxisGO:0050918330.015
negative regulation of leukocyte differentiationGO:1902106240.015
positive regulation of macrophage cytokine productionGO:006090710.015
positive regulation of immunoglobulin mediated immune responseGO:000289140.015
regulation of protein maturationGO:19033171500.015
response to other organismGO:00517072610.015
positive regulation of cell differentiationGO:00455972110.014
oogenesisGO:004847720.014
regulation of intracellular transport of viral materialGO:190125220.014
positive regulation of mapk cascadeGO:00434101900.014
negative regulation of cell substrate adhesionGO:0010812240.014
divalent metal ion transportGO:00708381520.014
negative regulation of protein metabolic processGO:00512483910.014
positive regulation of purine nucleotide metabolic processGO:19005442270.014
response to woundingGO:00096111680.013
regulation of ion transportGO:00432691890.013
regulation of neuron projection developmentGO:0010975570.013
acute inflammatory response to antigenic stimulusGO:000243810.013
positive regulation of cellular component organizationGO:00511303760.013
regulation of cellular component biogenesisGO:00440872810.013
cellular response to dexamethasone stimulusGO:007154910.013
negative regulation of intrinsic apoptotic signaling pathwayGO:2001243400.013
positive regulation of natural killer cell mediated immunityGO:0002717120.013
icosanoid biosynthetic processGO:0046456180.013
maintenance of locationGO:00512351120.012
vesicle mediated transportGO:00161923710.012
behaviorGO:00076101120.012
neuron developmentGO:00486661130.012
regulation of antigen processing and presentation of peptide or polysaccharide antigen via mhc class iiGO:000258040.012
Human
regulation of protein serine threonine kinase activityGO:00719001790.012
cell cell signalingGO:00072671550.012
regulation of cell substrate adhesionGO:0010810680.012
regulation of protein kinase activityGO:00458592890.012
cellular protein catabolic processGO:00442572610.012
purine containing compound catabolic processGO:00725234110.012
response to dexamethasoneGO:007154810.012
cell morphogenesisGO:00009022960.012
prostaglandin metabolic processGO:0006693170.012
positive regulation of calcium ion transport into cytosolGO:0010524200.012
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.012
metal ion homeostasisGO:00550651690.012
prostanoid biosynthetic processGO:0046457110.012
regulation of signal transduction by p53 class mediatorGO:1901796260.011
tissue homeostasisGO:0001894630.011
positive regulation of cell developmentGO:0010720920.011
response to abiotic stimulusGO:00096283360.011
positive regulation of granulocyte chemotaxisGO:007162490.011
negative regulation of lymphocyte apoptotic processGO:007022980.011
regulation of neuron differentiationGO:0045664700.011
determination of adult lifespanGO:000834020.011
wound healingGO:00420601150.011
myoblast fusionGO:000752010.011
positive regulation of isotype switchingGO:004583020.011
negative regulation of protein maturationGO:19033181420.011
sensory organ developmentGO:0007423520.011
regulation of acute inflammatory response to antigenic stimulusGO:000286410.011
regulation of vesicle mediated transportGO:00606271300.011
cellular calcium ion homeostasisGO:00068741170.011
regulation of cell divisionGO:00513021160.011
lipid metabolic processGO:00066293810.011
regulation of humoral immune responseGO:0002920110.011
purine ribonucleoside metabolic processGO:00461284370.011
leukocyte differentiationGO:0002521980.011
multicellular organismal metabolic processGO:0044236340.011
female gamete generationGO:000729220.011
positive regulation of innate immune responseGO:0045089790.011
regulation of anatomical structure sizeGO:00900661010.011
regulation of syncytium formation by plasma membrane fusionGO:006014220.010
intracellular protein transportGO:00068862700.010
response to radiationGO:00093141510.010
negative regulation of cell adhesionGO:0007162640.010
cellular macromolecule catabolic processGO:00442653800.010
mitotic cell cycle phase transitionGO:00447721620.010
cellular ion homeostasisGO:00068731680.010
positive regulation of b cell activationGO:0050871170.010
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.010

HLA-DRA disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
immune system diseaseDOID:29141550.997
Human
hypersensitivity reaction diseaseDOID:0060056250.956
Human
musculoskeletal system diseaseDOID:172230.746
central nervous system diseaseDOID:3311860.633
nervous system diseaseDOID:8634310.633
connective tissue diseaseDOID:651090.442
neurodegenerative diseaseDOID:12891020.263
bone diseaseDOID:0080001880.229
arthritisDOID:84880.108
bone inflammation diseaseDOID:3342100.108
rheumatoid arthritisDOID:714880.103
hematopoietic system diseaseDOID:741000.012
disease of cellular proliferationDOID:145661740.010
cancerDOID:1621670.010