Homo sapiens

50 known processes

POLA1

polymerase (DNA directed), alpha 1, catalytic subunit

(Aliases: DKFZp686K1672,POLA,p180)

POLA1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dna replicationGO:00062601161.000
dna dependent dna replicationGO:0006261440.999
double strand break repairGO:00063021010.991
post embryonic developmentGO:000979120.959
vesicle mediated transportGO:00161923710.947
cellular response to dna damage stimulusGO:00069743790.832
meiosis iGO:000712740.711
regulation of cell cycle phase transitionGO:19019871260.618
cell divisionGO:00513011680.597
dna replication initiationGO:000627060.577
endocytosisGO:00068971590.573
double strand break repair via homologous recombinationGO:0000724500.573
meiotic chromosome segregationGO:004513240.519
dna strand elongation involved in dna replicationGO:000627130.492
meiotic nuclear divisionGO:0007126100.484
gonad developmentGO:0008406340.469
mitotic cell cycle processGO:19030472860.441
mitotic cell cycleGO:00002783260.433
sex differentiationGO:0007548450.415
regulation of cell cycleGO:00517263930.377
receptor mediated endocytosisGO:0006898840.374
histone lysine methylationGO:0034968500.343
negative regulation of cell cycle processGO:00109481210.335
reproductive processGO:00224141060.307
Worm
g2 dna damage checkpointGO:0031572260.304
reproductive structure developmentGO:0048608550.294
embryo developmentGO:00097901230.273
Worm
single organism reproductive processGO:0044702980.257
Worm
dna damage checkpointGO:0000077680.255
nuclear divisionGO:00002801280.255
determination of adult lifespanGO:000834020.252
Worm
membrane organizationGO:00610242920.249
non recombinational repairGO:0000726140.216
embryo development ending in birth or egg hatchingGO:0009792340.210
Worm
organelle fissionGO:00482851490.187
dna repairGO:00062811980.181
developmental process involved in reproductionGO:0003006660.179
reproductive system developmentGO:0061458560.163
histone methylationGO:0016571600.160
nucleus organizationGO:0006997280.159
regulation of mitotic cell cycleGO:00073461890.159
protein alkylationGO:0008213740.157
nucleoside monophosphate catabolic processGO:00091251590.153
blastocyst developmentGO:000182430.153
microtubule based processGO:00070172100.152
regulation of meiotic cell cycleGO:005144540.152
development of primary sexual characteristicsGO:0045137350.146
dna conformation changeGO:00711031130.142
mitotic nuclear divisionGO:00070671190.140
protein localization to chromosome centromeric regionGO:0071459120.134
single organism carbohydrate metabolic processGO:00447231930.132
negative regulation of cell cycleGO:00457861930.130
regulation of cell cycle processGO:00105642660.127
negative regulation of mitotic cell cycleGO:00459301020.126
negative regulation of mitotic cell cycle phase transitionGO:1901991850.122
microtubule cytoskeleton organizationGO:00002261760.120
ribonucleoside monophosphate catabolic processGO:00091581580.115
positive regulation of cell proliferationGO:00082843010.109
telomere maintenanceGO:0000723320.108
nucleic acid phosphodiester bond hydrolysisGO:00903051020.105
mitotic dna integrity checkpointGO:0044774300.104
base excision repairGO:0006284210.101
engulfment of apoptotic cellGO:004365220.101
mitotic dna damage checkpointGO:0044773280.097
sister chromatid cohesionGO:0007062240.095
reciprocal meiotic recombinationGO:000713140.094
chromosome segregationGO:00070591140.093
g1 s transition of mitotic cell cycleGO:0000082780.092
cellular response to endogenous stimulusGO:00714953360.091
dna packagingGO:0006323770.088
male meiosisGO:000714010.088
regulation of dna replicationGO:0006275680.086
cellular response to nitrogen compoundGO:19016991440.086
cell cycle checkpointGO:00000751170.086
regulation of double strand break repairGO:2000779220.084
purine nucleoside triphosphate catabolic processGO:00091463920.082
covalent chromatin modificationGO:00165692540.081
regulation of mitotic cell cycle phase transitionGO:19019901180.080
growthGO:00400072020.079
dna strand elongationGO:002261650.079
histone h3 k4 methylationGO:0051568270.078
protein localization to organelleGO:00333652800.075
chordate embryonic developmentGO:0043009340.074
cellular amino acid metabolic processGO:00065201160.072
positive regulation of cellular component organizationGO:00511303760.071
cell cycle g1 s phase transitionGO:0044843800.070
nucleotide excision repairGO:0006289310.067
mitotic sister chromatid cohesionGO:0007064120.066
leading strand elongationGO:000627210.064
regulation of dna metabolic processGO:00510521530.059
cellular ketone metabolic processGO:0042180800.057
meiotic cell cycleGO:0051321130.056
Yeast
negative regulation of cell cycle phase transitionGO:1901988890.055
dna geometric changeGO:0032392320.052
mitotic cell cycle phase transitionGO:00447721620.052
double strand break repair via nonhomologous end joiningGO:0006303100.050
g2 m transition of mitotic cell cycleGO:0000086410.049
generation of neuronsGO:00486991520.049
lagging strand elongationGO:000627330.047
purine nucleotide catabolic processGO:00061954050.047
cell cycle phase transitionGO:00447701730.045
anatomical structure homeostasisGO:00602491000.044
regulation of cellular ketone metabolic processGO:0010565500.044
positive regulation of hydrolase activityGO:00513453310.043
negative regulation of meiotic cell cycleGO:005144720.042
protein dna complex subunit organizationGO:0071824800.042
methylationGO:00322591060.042
negative regulation of cell deathGO:00605483450.042
carbohydrate metabolic processGO:00059752070.041
response to purine containing compoundGO:0014074400.040
intracellular protein transportGO:00068862700.039
genitalia developmentGO:0048806100.039
tube developmentGO:00352951250.039
regulation of cellular amine metabolic processGO:0033238110.039
histone modificationGO:00165702510.039
regulation of cell cycle g1 s phase transitionGO:1902806420.039
cell activationGO:00017752130.039
sensory organ developmentGO:0007423520.038
regulation of cellular amino acid metabolic processGO:000652160.037
carbohydrate derivative biosynthetic processGO:19011372070.037
dna synthesis involved in dna repairGO:000073160.036
Yeast
response to organic cyclic compoundGO:00140702040.036
response to oxygen containing compoundGO:19017003690.036
reproductionGO:0000003630.035
Yeast Worm
regulation of g1 s transition of mitotic cell cycleGO:2000045400.035
nucleoside triphosphate metabolic processGO:00091414220.035
cellular amine metabolic processGO:0044106410.035
response to inorganic substanceGO:00100351270.034
dna integrity checkpointGO:0031570710.034
regulation of nucleocytoplasmic transportGO:0046822980.034
regulation of protein localizationGO:00328802960.034
mitotic cell cycle checkpointGO:0007093680.034
resolution of meiotic recombination intermediatesGO:000071230.033
purine ribonucleoside triphosphate catabolic processGO:00092073910.033
ribonucleoside triphosphate catabolic processGO:00092033910.033
cell projection morphogenesisGO:00488581290.033
ribonucleoside monophosphate metabolic processGO:00091611870.033
purine nucleoside monophosphate catabolic processGO:00091281580.032
telomere organizationGO:0032200330.032
female gamete generationGO:000729220.031
regulation of meiosisGO:004002030.030
protein ubiquitinationGO:00165673140.030
apoptotic cell clearanceGO:0043277120.030
positive regulation of immunoglobulin mediated immune responseGO:000289140.029
nucleoside triphosphate catabolic processGO:00091433940.029
negative regulation of dna metabolic processGO:0051053570.029
purine ribonucleoside metabolic processGO:00461284370.029
cellular response to organic cyclic compoundGO:00714071270.029
negative regulation of g1 s transition of mitotic cell cycleGO:2000134290.028
positive regulation of meiotic cell cycleGO:005144620.028
amine metabolic processGO:0009308440.028
dna dependent dna replication maintenance of fidelityGO:0045005140.028
negative regulation of apoptotic processGO:00430663160.028
nuclear transportGO:00511691790.028
rna dependent dna replicationGO:0006278160.027
Yeast
positive regulation of protein complex assemblyGO:0031334860.027
regulation of double strand break repair via homologous recombinationGO:0010569110.026
purine ribonucleoside catabolic processGO:00461303980.026
b cell activationGO:0042113330.026
purine containing compound catabolic processGO:00725234110.025
anatomical structure formation involved in morphogenesisGO:00486462840.025
epithelium developmentGO:00604292270.025
multi organism reproductive processGO:0044703540.024
Worm
response to nitrogen compoundGO:19016981840.024
regulation of cellular response to stressGO:00801352440.024
circulatory system developmentGO:00723592620.023
regenerationGO:003109940.023
somatic recombination of immunoglobulin genes involved in immune responseGO:000220430.023
cytoplasmic transportGO:00164823790.023
nucleoside catabolic processGO:00091644080.023
protein targetingGO:00066051870.023
cellular response to oxygen containing compoundGO:19017012760.023
cellular component disassemblyGO:0022411920.022
dna unwinding involved in dna replicationGO:000626820.022
intrinsic apoptotic signaling pathwayGO:00971931270.022
mitotic g2 m transition checkpointGO:004481890.022
purine nucleoside monophosphate metabolic processGO:00091261860.021
chromatin modificationGO:00165682980.021
regulation of dna methylationGO:004403020.021
cardiovascular system developmentGO:00723582620.021
defense response to bacteriumGO:0042742630.021
wound healingGO:00420601150.021
maintenance of dna repeat elementsGO:004357040.021
positive regulation of transportGO:00510503360.021
cell cycle g2 m phase transitionGO:0044839430.020
lymphocyte activationGO:00466491330.020
maintenance of locationGO:00512351120.020
chromatin organizationGO:00063253510.020
sister chromatid segregationGO:0000819540.019
positive regulation of dna replicationGO:0045740350.019
regulation of locomotionGO:00400123290.019
double strand break repair via single strand annealingGO:004500240.019
dna double strand break processingGO:0000729100.019
chromatin assembly or disassemblyGO:0006333780.019
regulation of intracellular transportGO:00323861950.019
cell type specific apoptotic processGO:00972851250.019
regulation of protein kinase activityGO:00458592890.019
macromolecule methylationGO:0043414970.018
regulation of kinase activityGO:00435493140.018
gene silencingGO:0016458490.018
nucleoside phosphate catabolic processGO:19012924120.018
positive regulation of cell cycleGO:00457871400.018
protein catabolic processGO:00301633250.017
dna modificationGO:0006304270.017
negative regulation of phosphate metabolic processGO:00459362670.017
regulation of cell activationGO:00508651250.017
positive regulation of cell cycle processGO:00900681060.017
positive regulation of protein transportGO:00512221350.017
positive regulation of intracellular protein transportGO:0090316760.016
dna recombinationGO:0006310770.016
positive regulation of intracellular transportGO:00323881040.016
hematopoietic or lymphoid organ developmentGO:00485341860.016
leukocyte activationGO:00453211640.016
ribonucleoside triphosphate metabolic processGO:00091994120.016
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.016
regulation of intracellular protein transportGO:00331571230.015
organophosphate biosynthetic processGO:00904071630.015
protein dna complex assemblyGO:0065004640.015
protein modification by small protein conjugationGO:00324463420.015
nervous system developmentGO:00073992930.015
multicellular organismal agingGO:001025930.015
Worm
organ morphogenesisGO:00098871470.015
response to extracellular stimulusGO:0009991850.015
phagocytosisGO:0006909420.015
regulation of peptidase activityGO:00525471800.015
purine ribonucleoside monophosphate catabolic processGO:00091691580.015
chromosome condensationGO:0030261150.015
microtubule anchoringGO:0034453240.014
response to ionizing radiationGO:0010212650.014
protein localization to chromosomeGO:0034502300.014
nucleotide catabolic processGO:00091664080.014
negative regulation of catalytic activityGO:00430863350.014
endomembrane system organizationGO:00102561960.014
mrna metabolic processGO:00160711750.014
peptide metabolic processGO:0006518510.014
nucleoside monophosphate metabolic processGO:00091231910.014
oocyte maturationGO:000155610.014
response to external biotic stimulusGO:00432072610.014
organophosphate catabolic processGO:00464344300.014
oogenesisGO:004847720.013
nuclear exportGO:0051168690.013
single organism cellular localizationGO:19025803320.013
segmentationGO:003528240.013
regulation of growthGO:00400081650.013
positive regulation of cytoskeleton organizationGO:0051495830.013
rna splicingGO:00083801310.013
positive regulation of dna metabolic processGO:0051054730.013
response to other organismGO:00517072610.013
positive regulation of cellular amino acid metabolic processGO:004576430.013
macromolecular complex disassemblyGO:0032984600.013
nitrogen compound transportGO:00717051910.013
dna duplex unwindingGO:0032508300.013
meiotic chromosome separationGO:005130730.013
neurogenesisGO:00220081690.013
response to organonitrogen compoundGO:00102431560.013
signal transduction by p53 class mediatorGO:0072331720.013
negative regulation of cellular protein metabolic processGO:00322693530.013
microtubule based movementGO:0007018320.013
regulation of dna dependent dna replicationGO:0090329190.013
isotype switchingGO:004519030.013
meiotic cell cycle processGO:190304680.013
Yeast
cellular macromolecule catabolic processGO:00442653800.013
regulation of lymphocyte activationGO:00512491030.013
positive regulation of cytoplasmic transportGO:1903651820.013
regulation of cytoskeleton organizationGO:00514931770.013
response to reactive oxygen speciesGO:0000302610.012
regulation of establishment of protein localizationGO:00702012420.012
positive regulation of leukocyte activationGO:0002696800.012
cell projection organizationGO:00300302520.012
cellular response to ionizing radiationGO:0071479320.012
regulation of cytoplasmic transportGO:19036491490.012
telomere maintenance via recombinationGO:000072240.012
positive regulation of cellular catabolic processGO:00313312840.012
head developmentGO:00603221080.012
nucleoside phosphate biosynthetic processGO:19012931090.012
protein methylationGO:0006479740.012
positive regulation of lymphocyte activationGO:0051251730.012
cell cell signalingGO:00072671550.011
regulation of leukocyte activationGO:00026941150.011
proteasomal protein catabolic processGO:00104981760.011
maintenance of protein location in cellGO:0032507560.011
attachment of spindle microtubules to kinetochoreGO:0008608170.011
nucleocytoplasmic transportGO:00069131760.011
internal protein amino acid acetylationGO:00064751010.011
regulation of chromosome organizationGO:00330441030.011
cell part morphogenesisGO:00329901370.011
positive regulation of nucleocytoplasmic transportGO:0046824540.011
glycosylationGO:0070085710.011
purine ribonucleotide catabolic processGO:00091544040.010
negative regulation of organelle organizationGO:00106391260.010
negative regulation of phosphorus metabolic processGO:00105632670.010
response to nutrient levelsGO:0031667810.010

POLA1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.028
cancerDOID:1621670.019
disease of metabolismDOID:00146672950.014
immune system diseaseDOID:29141550.012