Homo sapiens

28 known processes

MELK

maternal embryonic leucine zipper kinase

(Aliases: HPK38,KIAA0175)

MELK biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
mitotic cell cycle processGO:19030472860.308
nucleoside phosphate catabolic processGO:19012924120.289
purine nucleoside triphosphate catabolic processGO:00091463920.250
nuclear divisionGO:00002801280.241
chromosome segregationGO:00070591140.240
ribonucleotide catabolic processGO:00092614050.221
regulation of chromosome segregationGO:0051983440.214
mitotic cell cycleGO:00002783260.212
regulation of mitotic cell cycleGO:00073461890.195
microtubule based processGO:00070172100.191
purine ribonucleoside metabolic processGO:00461284370.190
mitotic nuclear divisionGO:00070671190.172
regulation of cell cycleGO:00517263930.169
single organism cellular localizationGO:19025803320.151
nucleoside triphosphate metabolic processGO:00091414220.148
post embryonic developmentGO:000979120.131
Worm
nucleoside monophosphate metabolic processGO:00091231910.127
nucleoside triphosphate catabolic processGO:00091433940.127
purine nucleoside catabolic processGO:00061523980.115
ribonucleoside triphosphate catabolic processGO:00092033910.115
organophosphate catabolic processGO:00464344300.113
meiotic chromosome segregationGO:004513240.113
nucleoside monophosphate catabolic processGO:00091251590.110
purine ribonucleoside triphosphate metabolic processGO:00092054110.106
ribonucleoside triphosphate metabolic processGO:00091994120.102
regulation of cell cycle processGO:00105642660.099
nucleotide catabolic processGO:00091664080.098
purine nucleotide catabolic processGO:00061954050.097
regulation of cellular response to stressGO:00801352440.091
centrosome organizationGO:0051297580.090
purine ribonucleoside catabolic processGO:00461303980.089
microtubule cytoskeleton organizationGO:00002261760.088
ribonucleoside catabolic processGO:00424544060.086
cytokinesisGO:0000910960.083
purine ribonucleoside triphosphate catabolic processGO:00092073910.074
sister chromatid segregationGO:0000819540.073
atp catabolic processGO:00062001570.071
purine nucleoside triphosphate metabolic processGO:00091444120.069
nucleoside catabolic processGO:00091644080.069
purine nucleoside monophosphate metabolic processGO:00091261860.069
purine ribonucleoside monophosphate metabolic processGO:00091671860.068
purine containing compound catabolic processGO:00725234110.067
glycosyl compound catabolic processGO:19016584130.067
maintenance of locationGO:00512351120.066
organelle assemblyGO:00709251760.066
cellular protein complex assemblyGO:00436231880.065
mitotic cell cycle phase transitionGO:00447721620.063
small gtpase mediated signal transductionGO:0007264780.063
organelle fissionGO:00482851490.062
microtubule organizing center organizationGO:0031023620.060
ribonucleoside monophosphate metabolic processGO:00091611870.059
ribonucleoside monophosphate catabolic processGO:00091581580.057
mitotic sister chromatid segregationGO:0000070530.056
ras protein signal transductionGO:0007265730.054
positive regulation of cell cycle processGO:00900681060.053
purine ribonucleotide catabolic processGO:00091544040.051
purine ribonucleoside monophosphate catabolic processGO:00091691580.051
vesicle mediated transportGO:00161923710.049
endomembrane system organizationGO:00102561960.049
response to abiotic stimulusGO:00096283360.049
maintenance of location in cellGO:0051651620.048
cell fate determinationGO:000170930.047
multicellular organismal agingGO:001025930.047
blastocyst developmentGO:000182430.046
regulation of dna metabolic processGO:00510521530.046
embryo developmentGO:00097901230.046
regulation of purine nucleotide metabolic processGO:19005422640.045
positive regulation of cell cycleGO:00457871400.044
negative regulation of cell cycleGO:00457861930.042
regulation of attachment of spindle microtubules to kinetochoreGO:005198890.042
positive regulation of phosphorylationGO:00423273940.041
protein catabolic processGO:00301633250.041
dna recombinationGO:0006310770.040
cellular macromolecular complex assemblyGO:00346223240.040
atp metabolic processGO:00460341760.040
oxidation reduction processGO:00551143960.040
protein localization to nucleusGO:00345041360.039
dna repairGO:00062811980.039
nervous system developmentGO:00073992930.038
Worm
regulation of protein localizationGO:00328802960.037
meiosis iGO:000712740.037
regulation of nucleotide metabolic processGO:00061402690.037
immune system developmentGO:00025201950.037
Zebrafish
spindle assemblyGO:0051225290.036
regulation of mitotic sister chromatid segregationGO:0033047270.035
purine nucleoside monophosphate catabolic processGO:00091281580.035
regulation of kinase activityGO:00435493140.034
nucleus localizationGO:005164710.033
positive regulation of nucleotide metabolic processGO:00459812300.033
anatomical structure formation involved in morphogenesisGO:00486462840.032
positive regulation of catabolic processGO:00098963100.032
cellular component morphogenesisGO:00329893140.032
dna packagingGO:0006323770.032
cell cell signalingGO:00072671550.031
regulation of small gtpase mediated signal transductionGO:00510561560.031
signal transduction by phosphorylationGO:00230142970.030
maintenance of protein locationGO:0045185570.030
positive regulation of purine nucleotide catabolic processGO:00331231850.030
regulation of nucleoside metabolic processGO:00091182090.030
positive regulation of hydrolase activityGO:00513453310.029
regulation of transferase activityGO:00513383550.029
regulation of cellular amine metabolic processGO:0033238110.029
guanosine containing compound metabolic processGO:19010682440.029
dephosphorylationGO:00163112090.029
regulation of mitotic cell cycle phase transitionGO:19019901180.029
cell divisionGO:00513011680.028
Worm
regulation of response to dna damage stimulusGO:2001020940.028
protein processingGO:00164852260.028
cell cycle phase transitionGO:00447701730.028
recombinational repairGO:0000725500.028
female gamete generationGO:000729220.028
positive regulation of protein kinase activityGO:00458601900.027
cellular component disassemblyGO:0022411920.027
spindle elongationGO:005123140.027
response to radiationGO:00093141510.027
cellular response to dna damage stimulusGO:00069743790.027
regulation of microtubule based processGO:0032886740.027
protein localization to organelleGO:00333652800.027
regenerationGO:003109940.027
negative regulation of cellular protein metabolic processGO:00322693530.027
ubiquitin dependent protein catabolic processGO:00065112060.026
cellular macromolecule catabolic processGO:00442653800.026
regulation of nucleotide catabolic processGO:00308112050.026
positive regulation of nucleotide catabolic processGO:00308131850.026
endocytosisGO:00068971590.026
regulation of cell cycle phase transitionGO:19019871260.025
circulatory system developmentGO:00723592620.025
negative regulation of programmed cell deathGO:00430693210.024
organ morphogenesisGO:00098871470.024
positive regulation of cell differentiationGO:00455972110.024
interspecies interaction between organismsGO:00444191560.024
determination of adult lifespanGO:000834020.024
organophosphate biosynthetic processGO:00904071630.024
establishment of nucleus localizationGO:004002310.024
positive regulation of cellular catabolic processGO:00313312840.024
cellular amine metabolic processGO:0044106410.024
negative regulation of mitotic cell cycleGO:00459301020.024
clearance of foreign intracellular dna by conversion of dna cytidine to uridineGO:004435610.024
negative regulation of protein metabolic processGO:00512483910.024
oogenesisGO:004847720.024
positive regulation of developmental processGO:00510943140.023
negative regulation of catalytic activityGO:00430863350.023
establishment of organelle localizationGO:0051656590.023
modification dependent macromolecule catabolic processGO:00436322120.022
positive regulation of kinase activityGO:00336742040.022
mitotic cell cycle checkpointGO:0007093680.022
regulation of mitosisGO:0007088630.022
central nervous system developmentGO:00074171230.022
positive regulation of nucleoside metabolic processGO:00459791860.022
cell activationGO:00017752130.022
regulation of proteolysisGO:00301622930.021
positive regulation of protein phosphorylationGO:00019343130.021
nuclear migrationGO:000709710.021
positive regulation of gtpase activityGO:00435471660.021
neurogenesisGO:00220081690.021
Worm
nucleotide biosynthetic processGO:00091651090.021
cardiovascular system developmentGO:00723582620.020
protein oligomerizationGO:00512591730.020
chromatin modificationGO:00165682980.020
proteolysis involved in cellular protein catabolic processGO:00516032440.020
positive regulation of dna metabolic processGO:0051054730.020
epithelium developmentGO:00604292270.020
regulation of purine nucleotide catabolic processGO:00331212050.020
regulation of dna repairGO:0006282470.020
regulation of mapk cascadeGO:00434082620.020
negative regulation of cell cycle phase transitionGO:1901988890.020
single organism reproductive processGO:0044702980.020
positive regulation of gtp catabolic processGO:00331261660.020
enzyme linked receptor protein signaling pathwayGO:00071673030.020
regulation of cell differentiationGO:00455953930.020
response to oxygen containing compoundGO:19017003690.019
response to decreased oxygen levelsGO:0036293960.019
cellular amino acid metabolic processGO:00065201160.019
gtp catabolic processGO:00061842370.019
spermatid differentiationGO:004851540.019
cellular lipid metabolic processGO:00442553030.019
positive regulation of purine nucleotide metabolic processGO:19005442270.019
single organism membrane organizationGO:00448022680.019
regulation of cytoplasmic transportGO:19036491490.019
cellular ketone metabolic processGO:0042180800.019
positive regulation of cell proliferationGO:00082843010.018
regulation of protein processingGO:00706131500.018
negative regulation of cellular component organizationGO:00511292350.018
regulation of cellular amino acid metabolic processGO:000652160.018
regulation of cell divisionGO:00513021160.018
developmental process involved in reproductionGO:0003006660.018
cellular component assembly involved in morphogenesisGO:0010927730.018
immune responseGO:00069553070.018
cell developmentGO:00484683280.017
Zebrafish
positive regulation of programmed cell deathGO:00430682490.017
Mouse
neuroblast divisionGO:005505710.017
Worm
reproductionGO:0000003630.017
negative regulation of apoptotic processGO:00430663160.017
regulation of cellular ketone metabolic processGO:0010565500.017
gtp metabolic processGO:00460392390.017
protein targetingGO:00066051870.016
regulation of ras protein signal transductionGO:00465781550.016
double strand break repair via homologous recombinationGO:0000724500.016
microtubule cytoskeleton organization involved in mitosisGO:1902850150.016
negative regulation of proteolysisGO:00458611320.016
negative regulation of mitotic cell cycle phase transitionGO:1901991850.016
intracellular protein transportGO:00068862700.016
double strand break repairGO:00063021010.016
dna conformation changeGO:00711031130.016
negative regulation of protein processingGO:00109551420.016
cellular response to endogenous stimulusGO:00714953360.015
response to hypoxiaGO:0001666960.015
negative regulation of phosphate metabolic processGO:00459362670.015
cellular response to oxidative stressGO:0034599850.015
Mouse
cofactor metabolic processGO:0051186870.015
guanosine containing compound catabolic processGO:19010692390.015
epithelial cell differentiationGO:00308551410.015
attachment of mitotic spindle microtubules to kinetochoreGO:005131530.015
cytoplasmic transportGO:00164823790.015
regulation of protein transportGO:00512232130.015
protein autophosphorylationGO:00467771230.015
reproductive structure developmentGO:0048608550.014
regulation of gtpase activityGO:00430871800.014
oocyte differentiationGO:000999420.014
meiotic nuclear divisionGO:0007126100.014
wnt signaling pathwayGO:00160551560.014
negative regulation of protein modification processGO:00314002000.014
negative regulation of cell cycle processGO:00109481210.014
negative regulation of cell deathGO:00605483450.014
embryo development ending in birth or egg hatchingGO:0009792340.014
positive regulation of organelle organizationGO:00106381950.014
positive regulation of protein transportGO:00512221350.014
positive regulation of transferase activityGO:00513472270.014
spindle organizationGO:0007051530.014
negative regulation of intracellular signal transductionGO:19025321830.014
tissue regenerationGO:004224630.014
protein maturationGO:00516042330.014
adult locomotory behaviorGO:000834410.013
digestive system developmentGO:0055123750.013
cell cycle checkpointGO:00000751170.013
regulation of cellular component biogenesisGO:00440872810.013
regulation of protein catabolic processGO:00421761550.013
spindle assembly involved in mitosisGO:0090307120.013
reproductive processGO:00224141060.013
heart developmentGO:0007507950.013
protein homooligomerizationGO:00512601000.013
cell morphogenesisGO:00009022960.013
cytoskeleton dependent cytokinesisGO:0061640220.013
oocyte developmentGO:004859910.013
actin filament based processGO:00300292240.013
negative regulation of phosphorus metabolic processGO:00105632670.013
regulation of protein kinase activityGO:00458592890.013
negative regulation of hydrolase activityGO:00513461820.013
cilium morphogenesisGO:0060271750.013
regulation of dna replicationGO:0006275680.013
sex differentiationGO:0007548450.013
regulation of cytoskeleton organizationGO:00514931770.013
regulation of anatomical structure morphogenesisGO:00226032860.013
mitotic cytokinesisGO:0000281190.013
regulation of nucleocytoplasmic transportGO:0046822980.013
carbohydrate derivative biosynthetic processGO:19011372070.013
mrna processingGO:00063971330.013
regulation of intracellular protein transportGO:00331571230.012
attachment of spindle microtubules to kinetochoreGO:0008608170.012
hemopoiesisGO:00300971800.012
Zebrafish
head developmentGO:00603221080.012
response to oxidative stressGO:00069791210.012
Mouse
blood vessel morphogenesisGO:00485141620.012
negative regulation of protein maturationGO:19033181420.012
response to light stimulusGO:0009416870.012
growthGO:00400072020.012
somatic muscle developmentGO:000752510.012
microtubule based movementGO:0007018320.012
cellular response to radiationGO:0071478650.012
nucleoside phosphate biosynthetic processGO:19012931090.012
locomotory behaviorGO:000762610.012
regulation of protein maturationGO:19033171500.012
reproductive system developmentGO:0061458560.012
cell cycle g1 s phase transitionGO:0044843800.012
positive regulation of mitotic cell cycleGO:0045931600.012
regulation of protein ubiquitinationGO:0031396950.012
cell projection organizationGO:00300302520.012
mitochondrial genome maintenanceGO:000000280.012
regulation of proteasomal protein catabolic processGO:0061136870.012
cell cycle g2 m phase transitionGO:0044839430.012
regulation of protein targetingGO:1903533910.012
chromatin remodelingGO:0006338550.011
positive regulation of cellular component organizationGO:00511303760.011
regulation of chromosome organizationGO:00330441030.011
positive regulation of cell deathGO:00109422630.011
Mouse
regulation of intracellular transportGO:00323861950.011
peptidyl serine phosphorylationGO:00181051010.011
regulation of peptidase activityGO:00525471800.011
organelle localizationGO:0051640840.011
negative regulation of organelle organizationGO:00106391260.011
sex determinationGO:000753030.011
biological adhesionGO:00226103310.011
dna replicationGO:00062601160.011
cell part morphogenesisGO:00329901370.011
myosin filament assemblyGO:003103420.011
centromere complex assemblyGO:0034508100.011
regulation of protein complex assemblyGO:00432541470.011
maintenance of protein location in cellGO:0032507560.011
tube developmentGO:00352951250.011
oocyte maturationGO:000155610.011
immune effector processGO:00022521590.011
striated muscle myosin thick filament assemblyGO:007168820.011
lymphocyte activationGO:00466491330.010
cellular response to oxygen containing compoundGO:19017012760.010
positive regulation of transportGO:00510503360.010
proteasomal protein catabolic processGO:00104981760.010
amine metabolic processGO:0009308440.010
regulation of protein import into nucleusGO:0042306780.010

MELK disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
immune system diseaseDOID:29141550.023
disease of cellular proliferationDOID:145661740.015