Homo sapiens

0 known processes

CLDN16

claudin 16

(Aliases: HOMG3,PCLN1)

CLDN16 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
detection of chemical stimulus involved in sensory perception of smellGO:005091120.087
cellular amine metabolic processGO:0044106410.077
regulation of cellular amine metabolic processGO:0033238110.071
cellular ketone metabolic processGO:0042180800.071
amine metabolic processGO:0009308440.067
water homeostasisGO:0030104140.067
Human
cellular amino acid metabolic processGO:00065201160.065
positive regulation of cellular amino acid metabolic processGO:004576430.062
positive regulation of cellular amine metabolic processGO:003324070.060
regulation of cellular amino acid metabolic processGO:000652160.059
lipid metabolic processGO:00066293810.053
post embryonic developmentGO:000979120.052
cation transportGO:00068123310.041
cellular response to endogenous stimulusGO:00714953360.041
ion transmembrane transportGO:00342203380.039
metal ion transportGO:00300012720.039
regulation of cellular ketone metabolic processGO:0010565500.039
ion homeostasisGO:00508012300.039
cellular lipid metabolic processGO:00442553030.038
response to organic cyclic compoundGO:00140702040.037
locomotory behaviorGO:000762610.037
regulation of cytokine productionGO:00018172320.037
sensory perception of smellGO:000760820.037
multicellular organismal agingGO:001025930.035
immune responseGO:00069553070.035
system processGO:00030083490.035
actin filament based processGO:00300292240.035
cytokine productionGO:00018162470.034
secretionGO:00469032540.034
determination of adult lifespanGO:000834020.034
positive regulation of phosphorylationGO:00423273940.034
transmembrane transportGO:00550853990.033
defense responseGO:00069523150.033
cation transmembrane transportGO:00986552380.033
regulation of transferase activityGO:00513383550.032
response to external biotic stimulusGO:00432072610.032
negative regulation of catalytic activityGO:00430863350.032
g protein coupled receptor signaling pathwayGO:00071862070.031
response to hypoxiaGO:0001666960.031
Human
positive regulation of protein phosphorylationGO:00019343130.030
regulation of cell cycleGO:00517263930.030
positive regulation of immune system processGO:00026842830.029
response to other organismGO:00517072610.029
response to oxygen containing compoundGO:19017003690.029
female gamete generationGO:000729220.029
enzyme linked receptor protein signaling pathwayGO:00071673030.029
metal ion homeostasisGO:00550651690.029
negative regulation of protein metabolic processGO:00512483910.028
regulation of kinase activityGO:00435493140.028
chemical homeostasisGO:00488783060.028
Human
response to lipidGO:00339932060.028
response to biotic stimulusGO:00096072760.028
neuromuscular junction developmentGO:000752830.028
negative regulation of cellular protein metabolic processGO:00322693530.028
response to decreased oxygen levelsGO:0036293960.028
Human
oogenesisGO:004847720.027
purine ribonucleoside metabolic processGO:00461284370.027
purine ribonucleoside triphosphate catabolic processGO:00092073910.027
ras protein signal transductionGO:0007265730.026
regulation of cell cycle processGO:00105642660.026
single organism cellular localizationGO:19025803320.026
micturitionGO:006007330.026
negative regulation of multicellular organismal processGO:00512413170.026
cytoplasmic transportGO:00164823790.026
positive regulation of cytokine productionGO:00018191670.026
response to cytokineGO:00340972320.025
positive regulation of cell proliferationGO:00082843010.025
nucleoside triphosphate metabolic processGO:00091414220.025
protein processingGO:00164852260.025
protein catabolic processGO:00301633250.025
negative regulation of cell deathGO:00605483450.024
positive regulation of transferase activityGO:00513472270.024
positive regulation of kinase activityGO:00336742040.024
purine nucleoside triphosphate metabolic processGO:00091444120.024
cellular cation homeostasisGO:00300031630.024
ribonucleoside triphosphate catabolic processGO:00092033910.024
regulation of protein kinase activityGO:00458592890.024
regulation of mapk cascadeGO:00434082620.024
glycosyl compound catabolic processGO:19016584130.024
cellular ion homeostasisGO:00068731680.024
innate immune responseGO:00450871780.024
cell junction organizationGO:0034330790.023
Human
cellular macromolecule catabolic processGO:00442653800.023
ribonucleoside triphosphate metabolic processGO:00091994120.023
muscle system processGO:0003012810.023
nucleoside phosphate catabolic processGO:19012924120.023
protein maturationGO:00516042330.023
mapk cascadeGO:00001652880.023
negative regulation of phosphorus metabolic processGO:00105632670.023
regulation of cellular component movementGO:00512703340.023
cellular chemical homeostasisGO:00550821800.023
purine containing compound catabolic processGO:00725234110.023
nucleotide catabolic processGO:00091664080.023
positive regulation of transportGO:00510503360.022
regulation of proteolysisGO:00301622930.022
membrane organizationGO:00610242920.022
signal transduction by phosphorylationGO:00230142970.022
regulation of nucleotide metabolic processGO:00061402690.022
negative regulation of acetylcholine gated cation channel activityGO:190304910.022
inorganic ion transmembrane transportGO:00986602310.022
cardiac muscle cell contractionGO:008600340.022
cellular homeostasisGO:00197251960.022
negative regulation of phosphate metabolic processGO:00459362670.022
organophosphate catabolic processGO:00464344300.022
protein localization to organelleGO:00333652800.022
cation homeostasisGO:00550801890.022
positive regulation of hydrolase activityGO:00513453310.022
regulation of protein localizationGO:00328802960.022
nucleoside catabolic processGO:00091644080.022
carbohydrate derivative biosynthetic processGO:19011372070.021
small gtpase mediated signal transductionGO:0007264780.021
cell cell junction organizationGO:0045216690.021
Human
regenerationGO:003109940.021
nucleoside triphosphate catabolic processGO:00091433940.021
purine ribonucleoside catabolic processGO:00461303980.021
synaptic transmission involved in micturitionGO:006008420.021
actin mediated cell contractionGO:0070252120.021
vesicle mediated transportGO:00161923710.021
cellular protein catabolic processGO:00442572610.021
positive regulation of mapk cascadeGO:00434101900.021
purine nucleoside triphosphate catabolic processGO:00091463920.021
cellular response to dna damage stimulusGO:00069743790.021
purine ribonucleoside triphosphate metabolic processGO:00092054110.021
regulation of response to external stimulusGO:00321012220.021
ribonucleoside catabolic processGO:00424544060.021
purine ribonucleotide catabolic processGO:00091544040.020
regulation of hormone levelsGO:00108171250.020
regulation of purine nucleotide metabolic processGO:19005422640.020
epidermis morphogenesisGO:004873030.020
apoptotic signaling pathwayGO:00971902680.020
response to abiotic stimulusGO:00096283360.020
Human
ribonucleotide catabolic processGO:00092614050.020
memoryGO:000761330.020
specification of organ identityGO:001009230.020
regulation of cellular response to stressGO:00801352440.020
positive regulation of developmental processGO:00510943140.020
anatomical structure formation involved in morphogenesisGO:00486462840.020
organonitrogen compound biosynthetic processGO:19015662000.020
negative regulation of apoptotic processGO:00430663160.020
cell divisionGO:00513011680.020
protein modification by small protein conjugationGO:00324463420.019
protein ubiquitinationGO:00165673140.019
intracellular protein transportGO:00068862700.019
response to bacteriumGO:00096171440.019
positive regulation of protein kinase activityGO:00458601900.019
single organism membrane organizationGO:00448022680.019
proteolysis involved in cellular protein catabolic processGO:00516032440.019
mitotic cell cycleGO:00002783260.019
purine nucleoside catabolic processGO:00061523980.019
regulation of protein transportGO:00512232130.019
regulation of immune responseGO:00507762010.019
rho protein signal transductionGO:0007266260.019
monovalent inorganic cation transportGO:00156721280.019
associative learningGO:000830610.019
striated muscle contractionGO:0006941520.019
segmentationGO:003528240.019
actin filament based movementGO:0030048170.018
nitrogen compound transportGO:00717051910.018
leukocyte activationGO:00453211640.018
purine nucleotide catabolic processGO:00061954050.018
blastoderm segmentationGO:000735020.018
peptidyl tyrosine phosphorylationGO:00181081700.018
positive regulation of programmed cell deathGO:00430682490.018
cell activationGO:00017752130.018
small molecule biosynthetic processGO:00442831570.018
regulation of establishment of protein localizationGO:00702012420.018
cellular response to cytokine stimulusGO:00713451810.018
cell projection organizationGO:00300302520.018
muscle contractionGO:0006936730.018
neurological system processGO:00508771630.018
regulation of intracellular transportGO:00323861950.018
cellular macromolecular complex assemblyGO:00346223240.018
fatty acid metabolic processGO:00066311150.018
positive regulation of nucleotide metabolic processGO:00459812300.017
maintenance of locationGO:00512351120.017
regulation of protein serine threonine kinase activityGO:00719001790.017
positive regulation of cellular component organizationGO:00511303760.017
regulation of acetylcholine gated cation channel activityGO:190304810.017
secretion by cellGO:00329402260.017
negative regulation of protein modification processGO:00314002000.017
regulation of cell migrationGO:00303342890.017
detection of chemical stimulusGO:0009593550.017
adult locomotory behaviorGO:000834410.017
posttranscriptional regulation of gene expressionGO:00106082130.017
cellular response to growth factor stimulusGO:00713631970.017
organ formationGO:004864530.017
reactive oxygen species biosynthetic processGO:190340940.017
regulation of locomotionGO:00400123290.017
negative regulation of transportGO:00510511760.017
nuclear transportGO:00511691790.017
negative regulation of programmed cell deathGO:00430693210.017
positive regulation of cell deathGO:00109422630.017
positive regulation of purine nucleotide metabolic processGO:19005442270.017
positive regulation of apoptotic processGO:00430652460.017
dephosphorylationGO:00163112090.017
photoreceptor cell differentiationGO:004653020.017
response to inorganic substanceGO:00100351270.017
response to hormoneGO:00097251750.017
regulation of reactive oxygen species biosynthetic processGO:190342630.016
mitotic cell cycle processGO:19030472860.016
organic hydroxy compound metabolic processGO:19016151470.016
regulation of cell divisionGO:00513021160.016
regulation of cell differentiationGO:00455953930.016
skin developmentGO:0043588760.016
Human
cellular response to oxygen containing compoundGO:19017012760.016
epithelium developmentGO:00604292270.016
circulatory system developmentGO:00723592620.016
alcohol metabolic processGO:00060661140.016
reactive nitrogen species metabolic processGO:200105730.016
regulation of cellular component biogenesisGO:00440872810.016
regulation of anatomical structure morphogenesisGO:00226032860.016
anion transportGO:00068201610.016
oxidation reduction processGO:00551143960.016
divalent inorganic cation homeostasisGO:00725071360.016
lipid biosynthetic processGO:00086101770.016
single organism carbohydrate metabolic processGO:00447231930.016
regulation of nucleoside metabolic processGO:00091182090.016
growthGO:00400072020.016
epithelial cell proliferationGO:00506731280.015
interspecies interaction between organismsGO:00444191560.015
release of cytoplasmic sequestered nf kappabGO:000858840.015
anterior posterior axis specificationGO:000994820.015
regulation of secretion by cellGO:19035301770.015
morphogenesis of embryonic epitheliumGO:001633140.015
peptidyl tyrosine modificationGO:00182121700.015
positive regulation of cell cycleGO:00457871400.015
cellular component morphogenesisGO:00329893140.015
response to fungusGO:000962040.015
negative regulation of intracellular signal transductionGO:19025321830.015
positive regulation of reactive oxygen species biosynthetic processGO:190342820.015
monocarboxylic acid metabolic processGO:00327871850.015
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.015
negative regulation of cell proliferationGO:00082852280.015
chemotaxisGO:00069351570.015
inorganic cation transmembrane transportGO:00986621940.015
reactive oxygen species metabolic processGO:0072593750.015
hematopoietic or lymphoid organ developmentGO:00485341860.015
negative regulation of developmental processGO:00510932470.015
modification dependent macromolecule catabolic processGO:00436322120.015
regulation of protein catabolic processGO:00421761550.015
modification dependent protein catabolic processGO:00199412090.015
cellular metal ion homeostasisGO:00068751460.015
regulation of endopeptidase activityGO:00525481700.015
protein importGO:00170381300.015
nervous system developmentGO:00073992930.015
negative regulation of cellular amino acid metabolic processGO:004576320.015
multicellular organismal signalingGO:0035637340.015
spermatid differentiationGO:004851540.015
establishment of protein localization to organelleGO:00725941720.015
oocyte developmentGO:004859910.015
cell morphogenesisGO:00009022960.015
cellular response to organic cyclic compoundGO:00714071270.015
biological adhesionGO:00226103310.015
negative regulation of interleukin 13 secretionGO:200066610.015
cellular response to lipidGO:00713961270.015
inner ear morphogenesisGO:004247240.015
actin cytoskeleton organizationGO:00300362070.014
cellular divalent inorganic cation homeostasisGO:00725031280.014
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.014
response to metal ionGO:0010038840.014
response to nitrogen compoundGO:19016981840.014
circadian behaviorGO:004851220.014
nucleoside phosphate biosynthetic processGO:19012931090.014
positive regulation of cellular catabolic processGO:00313312840.014
positive regulation of catabolic processGO:00098963100.014
ubiquitin dependent protein catabolic processGO:00065112060.014
purine nucleoside monophosphate metabolic processGO:00091261860.014
multi organism cellular processGO:00447641560.014
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.014
negative regulation of hydrolase activityGO:00513461820.014
multicellular organismal water homeostasisGO:0050891140.014
Human
negative regulation of cytokine productionGO:0001818820.014
negative regulation of cellular amine metabolic processGO:003323930.014
regulation of cytoplasmic transportGO:19036491490.014
cell cycle phase transitionGO:00447701730.014
regulation of peptidase activityGO:00525471800.014
embryonic epithelial tube formationGO:000183840.014
calcium ion homeostasisGO:00550741220.014
negative regulation of phosphorylationGO:00423261740.014
regulation of secretionGO:00510461940.014
taxisGO:00423301570.014
protein targetingGO:00066051870.014
symbiosis encompassing mutualism through parasitismGO:00444031560.014
response to organonitrogen compoundGO:00102431560.014
alpha ketoglutarate transportGO:001574210.014
syncytium formation by plasma membrane fusionGO:000076820.014
cell adhesionGO:00071553250.014
endomembrane system organizationGO:00102561960.014
regulation of reactive oxygen species metabolic processGO:2000377410.014
hemopoiesisGO:00300971800.014
purine ribonucleoside monophosphate metabolic processGO:00091671860.014
positive regulation of organelle organizationGO:00106381950.013
vasculature developmentGO:00019441810.013
sodium dependent organic cation transportGO:007071510.013
short chain fatty acid importGO:001591310.013
postsynaptic membrane organizationGO:000194120.013
positive regulation of leukocyte activationGO:0002696800.013
regulation of cell motilityGO:20001452990.013
atp metabolic processGO:00460341760.013
oocyte differentiationGO:000999420.013
hair follicle morphogenesisGO:003106920.013
cell chemotaxisGO:00603261120.013
matingGO:000761810.013
regulation of sequence specific dna binding transcription factor activityGO:00510902110.013
regulation of peptidyl serine phosphorylation of stat proteinGO:003313930.013
regulation of membrane potentialGO:0042391950.013
somatic stem cell maintenanceGO:003501940.013
visual learningGO:000854210.013
spermatid developmentGO:000728640.013
regulation of multi organism processGO:00439001570.013
nucleoside monophosphate metabolic processGO:00091231910.013
proteasomal protein catabolic processGO:00104981760.013
positive regulation of cytosolic calcium ion concentrationGO:0007204820.013
regulation of apoptotic signaling pathwayGO:20012331750.013
carbohydrate metabolic processGO:00059752070.013
negative regulation of protein processingGO:00109551420.013
regulation of cytoskeleton organizationGO:00514931770.013
positive regulation of cell differentiationGO:00455972110.013
mitotic cell cycle phase transitionGO:00447721620.013
dna repairGO:00062811980.013
regulation of protein maturationGO:19033171500.013
rhythmic behaviorGO:000762220.013
cellular response to hormone stimulusGO:00328701250.013
peripheral nervous system developmentGO:000742220.013
positive regulation of cell cycle processGO:00900681060.013
sulfur compound metabolic processGO:00067901010.013
cellular calcium ion homeostasisGO:00068741170.013
organophosphate biosynthetic processGO:00904071630.013
regulation of purine nucleotide catabolic processGO:00331212050.013
sequestering of metal ionGO:0051238240.012
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.012
organelle assemblyGO:00709251760.012
guanosine containing compound metabolic processGO:19010682440.012
angiogenesisGO:00015251470.012
regulation of defense responseGO:00313471540.012
visual behaviorGO:000763220.012
response to growth factorGO:00708482050.012
microtubule based processGO:00070172100.012
adenylate cyclase inhibiting opioid receptor signaling pathwayGO:003163510.012
regulation of protein processingGO:00706131500.012
ribonucleoside monophosphate metabolic processGO:00091611870.012
regulation of cysteine type endopeptidase activityGO:20001161270.012
negative regulation of immune system processGO:00026831360.012
protein localization to nucleusGO:00345041360.012
immune system developmentGO:00025201950.012
positive regulation of response to external stimulusGO:0032103880.012
cellular response to nitrogen compoundGO:19016991440.012
cd4 positive alpha beta t cell cytokine productionGO:003574340.012
regulation of cell activationGO:00508651250.012
negative regulation of proteolysisGO:00458611320.012
detection of chemical stimulus involved in sensory perceptionGO:0050907330.012
cell developmentGO:00484683280.012
anatomical structure homeostasisGO:00602491000.012
positive regulation of cell migrationGO:00303351720.012
lung alveolus developmentGO:004828640.012
behavioral response to ethanolGO:004814920.012
immune effector processGO:00022521590.012
positive regulation of reactive oxygen species metabolic processGO:2000379240.012
regulation of epithelial cell proliferationGO:00506781130.012
regulation of actin filament based processGO:00329701410.012
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.012
response to extracellular stimulusGO:0009991850.012
positive regulation of immune responseGO:00507781590.012
behaviorGO:00076101120.012
compound eye developmentGO:004874910.012
regulation of nucleotide catabolic processGO:00308112050.012
cell growthGO:00160491600.012
hindbrain developmentGO:003090230.012
nucleocytoplasmic transportGO:00069131760.012
cellular protein complex assemblyGO:00436231880.012
defense response to other organismGO:00985421290.012
positive regulation of cellular component biogenesisGO:00440891580.012
epithelial cell differentiationGO:00308551410.012
positive regulation of hormone biosynthetic processGO:004688640.012
cyclic nucleotide metabolic processGO:0009187820.012
carnitine transmembrane transportGO:190260330.012
positive regulation of protein transportGO:00512221350.012
regulation of peptidyl tyrosine phosphorylationGO:00507301080.012
acetate ester metabolic processGO:190061930.012
gtp metabolic processGO:00460392390.012
phototransductionGO:000760230.012
detection of stimulusGO:0051606850.012
divalent metal ion transportGO:00708381520.012
cardiovascular system developmentGO:00723582620.012
negative regulation of t helper 2 cell cytokine productionGO:200055220.011
purine containing compound biosynthetic processGO:0072522880.011
regulation of protein stabilityGO:0031647870.011
negative regulation of cell cycleGO:00457861930.011
negative regulation of cellular component organizationGO:00511292350.011
regulation of protein secretionGO:0050708860.011
negative regulation of protein phosphorylationGO:00019331400.011
regulation of meiotic cell cycleGO:005144540.011
i kappab kinase nf kappab signalingGO:00072491660.011
response to woundingGO:00096111680.011
rna processingGO:00063962550.011
regulation of mitotic cell cycleGO:00073461890.011
activation of immune responseGO:00022531140.011
guanosine containing compound catabolic processGO:19010692390.011
protein oligomerizationGO:00512591730.011
steroid metabolic processGO:0008202940.011
purine nucleotide biosynthetic processGO:0006164840.011
viral processGO:00160321460.011
tripartite regional subdivisionGO:000735120.011
regulation of cytokinesisGO:0032465450.011
neuroblast proliferationGO:000740540.011
cytokinesisGO:0000910960.011
negative regulation of interleukin 5 productionGO:003271430.011
hormone metabolic processGO:0042445610.011
salivary gland morphogenesisGO:000743540.011
neurogenesisGO:00220081690.011
defense response to fungusGO:005083240.011
negative regulation of interleukin 5 secretionGO:200066310.011
pulmonary valve formationGO:000319310.011
regulation of growthGO:00400081650.011
sensory perceptionGO:00076001030.011
regulation of lipid metabolic processGO:0019216960.011
negative regulation of protein maturationGO:19033181420.011
regulation of map kinase activityGO:00434051080.011
regulation of ion transportGO:00432691890.011
positive regulation of keratinocyte proliferationGO:001083840.011
vasodilationGO:004231140.011
nucleoside monophosphate catabolic processGO:00091251590.011
cellular response to organonitrogen compoundGO:00714171240.011
regulation of oxidoreductase activityGO:0051341430.011
blood vessel morphogenesisGO:00485141620.011
protein localization to membraneGO:00726571600.011
positive regulation of locomotionGO:00400171860.011
regulation of leukocyte activationGO:00026941150.011
negative regulation of transferase activityGO:00513481240.011
regulation of system processGO:00440571010.011
nuclear importGO:00511701060.011
keratinizationGO:003142420.011
regulation of i kappab kinase nf kappab signalingGO:00431221620.011
response to axon injuryGO:004867810.011
protein autophosphorylationGO:00467771230.011
positive regulation of cellular component movementGO:00512721810.011
divalent inorganic cation transportGO:00725111580.011
response to oxygen levelsGO:00704821000.011
Human
regulation of intracellular protein transportGO:00331571230.011
cytokine mediated signaling pathwayGO:00192211090.011
synaptic transmission cholinergicGO:000727120.011
cellular response to genisteinGO:007141210.011
anterior posterior axis specification embryoGO:000859520.011
sequestering of calcium ionGO:0051208170.011
positive regulation of proteolysisGO:00458621420.011
wnt signaling pathwayGO:00160551560.011
copulationGO:000762010.011
anion transmembrane transportGO:0098656760.011
positive regulation of protein serine threonine kinase activityGO:00719021190.011
establishment of protein localization to membraneGO:00901501210.011
regulation of transmembrane transportGO:00347621390.011
intracellular receptor signaling pathwayGO:00305221040.011
positive regulation of cell divisionGO:0051781590.011
cell projection assemblyGO:00300311260.011
positive regulation of purine nucleotide catabolic processGO:00331231850.011
positive regulation of peptidyl serine phosphorylation of stat proteinGO:003314130.011
regulation of transporter activityGO:0032409820.011
viral life cycleGO:00190581320.011
response to oxidative stressGO:00069791210.011
lipid transportGO:0006869900.011
circulatory system processGO:00030131130.011
nerve developmentGO:002167540.011
sodium independent organic anion transportGO:004325220.010
histone modificationGO:00165702510.010
positive regulation of acrosome reactionGO:200034440.010
positive regulation of secretionGO:00510471160.010
positive regulation of nucleoside metabolic processGO:00459791860.010
chromatin organizationGO:00063253510.010

CLDN16 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.027
sensory system diseaseDOID:00501552030.021
nervous system diseaseDOID:8634310.021
disease of metabolismDOID:00146672950.020
urinary system diseaseDOID:18400.016
kidney diseaseDOID:557360.015
disease of cellular proliferationDOID:145661740.015
central nervous system diseaseDOID:3311860.015
myopathyDOID:4231040.015
muscular diseaseDOID:00800001140.015
muscle tissue diseaseDOID:661130.015
cancerDOID:1621670.015
organ system cancerDOID:00506861640.015
eye and adnexa diseaseDOID:14921500.015
eye diseaseDOID:56141490.014
inherited metabolic disorderDOID:6552420.014
bone diseaseDOID:0080001880.013
connective tissue diseaseDOID:651090.013
retinal diseaseDOID:56791180.012
immune system diseaseDOID:29141550.012
cardiovascular system diseaseDOID:12871060.011
cardiomyopathyDOID:0050700500.011
intrinsic cardiomyopathyDOID:0060036500.011
heart diseaseDOID:114680.011
neurodegenerative diseaseDOID:12891020.011