Homo sapiens

130 known processes

GCLC

glutamate-cysteine ligase, catalytic subunit

(Aliases: GLCL,GCS,GCL,GLCLC)

GCLC biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
glutathione metabolic processGO:0006749200.984
nonribosomal peptide biosynthetic processGO:001918440.952
glutathione biosynthetic processGO:000675040.932
glutamate metabolic processGO:0006536100.921
cellular amino acid biosynthetic processGO:0008652300.780
amide biosynthetic processGO:0043604150.765
dicarboxylic acid metabolic processGO:0043648290.757
sulfur compound biosynthetic processGO:0044272380.704
glutamine family amino acid metabolic processGO:0009064170.665
cellular modified amino acid biosynthetic processGO:0042398150.662
cysteine metabolic processGO:000653440.608
sulfur compound metabolic processGO:00067901010.601
organic acid biosynthetic processGO:0016053970.533
cellular modified amino acid metabolic processGO:0006575640.532
small molecule biosynthetic processGO:00442831570.452
carboxylic acid biosynthetic processGO:0046394970.443
sulfur amino acid metabolic processGO:0000096140.436
regulation of blood vessel sizeGO:0050880180.263
peptide metabolic processGO:0006518510.218
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237520.217
Mouse
alpha amino acid metabolic processGO:1901605720.209
regulation of mitochondrial membrane potentialGO:0051881230.208
Mouse
negative regulation of apoptotic signaling pathwayGO:2001234970.197
Mouse
regulation of ion homeostasisGO:2000021730.194
Mouse
ion homeostasisGO:00508012300.181
Mouse
extrinsic apoptotic signaling pathwayGO:00971911190.165
Mouse
mitochondrion organizationGO:00070051560.163
Mouse
regulation of apoptotic signaling pathwayGO:20012331750.151
Mouse
response to oxidative stressGO:00069791210.150
negative regulation of cell deathGO:00605483450.149
regulation of ligase activityGO:0051340290.149
system processGO:00030083490.146
negative regulation of programmed cell deathGO:00430693210.145
regulation of membrane potentialGO:0042391950.132
Mouse
negative regulation of apoptotic processGO:00430663160.125
regulation of tube sizeGO:0035150180.121
apoptotic signaling pathwayGO:00971902680.119
Mouse
regulation of homeostatic processGO:00328441210.112
Mouse
cellular amino acid metabolic processGO:00065201160.107
vascular process in circulatory systemGO:0003018290.085
oxidation reduction processGO:00551143960.085
cellular lipid metabolic processGO:00442553030.068
post embryonic developmentGO:000979120.068
monocarboxylic acid metabolic processGO:00327871850.062
regulation of mitochondrial depolarizationGO:005190060.058
Mouse
response to drugGO:0042493810.058
cellular ketone metabolic processGO:0042180800.058
amine metabolic processGO:0009308440.058
regulation of cellular ketone metabolic processGO:0010565500.053
glycosyl compound catabolic processGO:19016584130.051
regulation of membrane depolarizationGO:0003254190.049
Mouse
cellular amine metabolic processGO:0044106410.048
ribonucleotide catabolic processGO:00092614050.044
multicellular organismal agingGO:001025930.044
positive regulation of ligase activityGO:0051351190.042
purine nucleoside triphosphate catabolic processGO:00091463920.041
regulation of cellular amino acid metabolic processGO:000652160.041
female gamete generationGO:000729220.041
positive regulation of cellular amino acid metabolic processGO:004576430.041
lipid metabolic processGO:00066293810.041
purine ribonucleoside triphosphate catabolic processGO:00092073910.041
regulation of cellular amine metabolic processGO:0033238110.041
positive regulation of cellular amine metabolic processGO:003324070.040
purine nucleotide catabolic processGO:00061954050.040
positive regulation of hydrolase activityGO:00513453310.039
nucleoside triphosphate catabolic processGO:00091433940.038
determination of adult lifespanGO:000834020.038
purine containing compound catabolic processGO:00725234110.037
protein oligomerizationGO:00512591730.037
nucleoside triphosphate metabolic processGO:00091414220.036
ras protein signal transductionGO:0007265730.036
transmembrane transportGO:00550853990.034
regulation of proteolysisGO:00301622930.033
Mouse
negative regulation of cellular protein metabolic processGO:00322693530.033
Mouse
positive regulation of catabolic processGO:00098963100.032
Mouse
cellular macromolecule catabolic processGO:00442653800.032
Mouse
locomotory behaviorGO:000762610.032
positive regulation of cellular catabolic processGO:00313312840.031
Mouse
reactive oxygen species metabolic processGO:0072593750.031
negative regulation of protein metabolic processGO:00512483910.031
Mouse
purine nucleoside triphosphate metabolic processGO:00091444120.031
cellular response to oxygen containing compoundGO:19017012760.030
cytokine productionGO:00018162470.030
segmentationGO:003528240.030
response to organic cyclic compoundGO:00140702040.030
organonitrogen compound biosynthetic processGO:19015662000.029
cytoplasmic transportGO:00164823790.029
purine ribonucleotide catabolic processGO:00091544040.029
carbohydrate metabolic processGO:00059752070.029
Mouse
fatty acid metabolic processGO:00066311150.029
protein ubiquitinationGO:00165673140.029
Mouse
chemical homeostasisGO:00488783060.029
Mouse
neuromuscular junction developmentGO:000752830.029
ribonucleoside catabolic processGO:00424544060.028
single organism cellular localizationGO:19025803320.028
small gtpase mediated signal transductionGO:0007264780.028
ion transmembrane transportGO:00342203380.027
purine ribonucleoside catabolic processGO:00461303980.026
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.026
nucleoside catabolic processGO:00091644080.026
organic hydroxy compound metabolic processGO:19016151470.025
positive regulation of transportGO:00510503360.025
regulation of cellular response to stressGO:00801352440.025
oogenesisGO:004847720.025
response to oxygen containing compoundGO:19017003690.024
Worm
vesicle mediated transportGO:00161923710.024
purine nucleoside monophosphate metabolic processGO:00091261860.024
biological adhesionGO:00226103310.024
regulation of cell cycleGO:00517263930.024
ribonucleoside triphosphate metabolic processGO:00091994120.024
purine ribonucleoside metabolic processGO:00461284370.024
membrane organizationGO:00610242920.024
cofactor metabolic processGO:0051186870.024
regulation of purine nucleotide metabolic processGO:19005422640.024
cellular protein catabolic processGO:00442572610.024
Mouse
anion transportGO:00068201610.024
positive regulation of cell proliferationGO:00082843010.024
ribonucleoside monophosphate metabolic processGO:00091611870.023
cellular homeostasisGO:00197251960.023
positive regulation of phosphorylationGO:00423273940.023
mitotic cell cycleGO:00002783260.023
response to abiotic stimulusGO:00096283360.023
defense responseGO:00069523150.022
positive regulation of programmed cell deathGO:00430682490.022
negative regulation of protein modification processGO:00314002000.022
Mouse
metal ion transportGO:00300012720.022
cation transportGO:00068123310.022
cell adhesionGO:00071553250.022
cellular response to oxidative stressGO:0034599850.022
signal transduction by phosphorylationGO:00230142970.022
cation homeostasisGO:00550801890.022
regulation of kinase activityGO:00435493140.022
single organism membrane organizationGO:00448022680.022
organophosphate catabolic processGO:00464344300.022
negative regulation of phosphorus metabolic processGO:00105632670.022
intracellular protein transportGO:00068862700.022
protein homooligomerizationGO:00512601000.022
regulation of nucleotide catabolic processGO:00308112050.022
mapk cascadeGO:00001652880.022
nucleoside phosphate catabolic processGO:19012924120.021
immune responseGO:00069553070.021
positive regulation of organelle organizationGO:00106381950.021
blastoderm segmentationGO:000735020.021
microtubule based processGO:00070172100.021
regulation of purine nucleotide catabolic processGO:00331212050.021
regulation of cellular component biogenesisGO:00440872810.021
purine nucleoside catabolic processGO:00061523980.021
nucleotide catabolic processGO:00091664080.021
reactive oxygen species biosynthetic processGO:190340940.020
small molecule catabolic processGO:0044282920.020
regulation of protein kinase activityGO:00458592890.020
cardiovascular system developmentGO:00723582620.020
endomembrane system organizationGO:00102561960.020
mitochondrial depolarizationGO:005188260.020
Mouse
oocyte developmentGO:004859910.020
morphogenesis of embryonic epitheliumGO:001633140.020
positive regulation of nucleoside metabolic processGO:00459791860.020
purine ribonucleoside triphosphate metabolic processGO:00092054110.020
anterior posterior axis specificationGO:000994820.020
negative regulation of catalytic activityGO:00430863350.020
guanosine containing compound metabolic processGO:19010682440.020
inorganic ion transmembrane transportGO:00986602310.020
spermatid differentiationGO:004851540.019
metal ion homeostasisGO:00550651690.019
purine ribonucleoside monophosphate metabolic processGO:00091671860.019
regulation of cytokine productionGO:00018172320.019
gtp metabolic processGO:00460392390.019
cellular response to dna damage stimulusGO:00069743790.019
positive regulation of nucleotide catabolic processGO:00308131850.019
endosomal transportGO:00161971290.019
atp metabolic processGO:00460341760.019
positive regulation of purine nucleotide catabolic processGO:00331231850.019
negative regulation of hydrolase activityGO:00513461820.019
response to hormoneGO:00097251750.019
peripheral nervous system developmentGO:000742220.019
positive regulation of cellular component organizationGO:00511303760.019
protein modification by small protein conjugationGO:00324463420.019
Mouse
regulation of intracellular transportGO:00323861950.019
rho protein signal transductionGO:0007266260.019
embryonic epithelial tube formationGO:000183840.019
positive regulation of purine nucleotide metabolic processGO:19005442270.019
single organism carbohydrate metabolic processGO:00447231930.019
Mouse
regenerationGO:003109940.019
regulation of multi organism processGO:00439001570.018
regulation of mapk cascadeGO:00434082620.018
protein targetingGO:00066051870.018
positive regulation of apoptotic processGO:00430652460.018
nucleoside monophosphate metabolic processGO:00091231910.018
positive regulation of transferase activityGO:00513472270.018
positive regulation of nucleotide metabolic processGO:00459812300.018
negative regulation of phosphate metabolic processGO:00459362670.018
rna processingGO:00063962550.018
positive regulation of kinase activityGO:00336742040.018
establishment of protein localization to organelleGO:00725941720.018
protein catabolic processGO:00301633250.018
Mouse
purine ribonucleoside monophosphate catabolic processGO:00091691580.018
spermatid developmentGO:000728640.018
protein localization to membraneGO:00726571600.018
innate immune responseGO:00450871780.018
regulation of transferase activityGO:00513383550.018
proteasomal protein catabolic processGO:00104981760.018
Mouse
regulation of reactive oxygen species biosynthetic processGO:190342630.018
organophosphate biosynthetic processGO:00904071630.018
adult locomotory behaviorGO:000834410.018
positive regulation of cell deathGO:00109422630.018
tripartite regional subdivisionGO:000735120.018
positive regulation of reactive oxygen species metabolic processGO:2000379240.017
response to cytokineGO:00340972320.017
negative regulation of cellular amino acid metabolic processGO:004576320.017
negative regulation of cellular amine metabolic processGO:003323930.017
anterior posterior axis specification embryoGO:000859520.017
regulation of gtpase activityGO:00430871800.017
dna repairGO:00062811980.017
proteolysis involved in cellular protein catabolic processGO:00516032440.017
Mouse
regulation of ras protein signal transductionGO:00465781550.017
maintenance of locationGO:00512351120.017
protein maturationGO:00516042330.017
response to biotic stimulusGO:00096072760.017
ribonucleoside monophosphate catabolic processGO:00091581580.017
cellular amide metabolic processGO:0043603690.017
retinoic acid biosynthetic processGO:000213820.017
positive regulation of immune system processGO:00026842830.017
negative regulation of cellular component organizationGO:00511292350.017
response to other organismGO:00517072610.017
secretionGO:00469032540.016
oocyte differentiationGO:000999420.016
cell morphogenesisGO:00009022960.016
regulation of secretion by cellGO:19035301770.016
regulation of response to external stimulusGO:00321012220.016
mitotic cell cycle processGO:19030472860.016
purine nucleoside monophosphate catabolic processGO:00091281580.016
cellular macromolecular complex assemblyGO:00346223240.016
dephosphorylationGO:00163112090.016
ubiquitin dependent protein catabolic processGO:00065112060.016
Mouse
negative regulation of intracellular signal transductionGO:19025321830.016
regulation of sequence specific dna binding transcription factor activityGO:00510902110.016
rhythmic behaviorGO:000762220.016
organic anion transportGO:00157111030.016
positive regulation of protein phosphorylationGO:00019343130.016
cellular component morphogenesisGO:00329893140.016
actin filament based processGO:00300292240.016
regulation of protein localizationGO:00328802960.016
ribonucleoside triphosphate catabolic processGO:00092033910.016
memoryGO:000761330.016
nervous system developmentGO:00073992930.016
regulation of growthGO:00400081650.016
response to external biotic stimulusGO:00432072610.016
microtubule cytoskeleton organizationGO:00002261760.016
regulation of protein serine threonine kinase activityGO:00719001790.016
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.016
Mouse
regulation of cell motilityGO:20001452990.016
photoreceptor cell differentiationGO:004653020.015
cellular response to cytokine stimulusGO:00713451810.015
hindbrain developmentGO:003090230.015
regulation of cellular component movementGO:00512703340.015
regulation of anatomical structure morphogenesisGO:00226032860.015
nucleoside monophosphate catabolic processGO:00091251590.015
positive regulation of developmental processGO:00510943140.015
cell projection organizationGO:00300302520.015
regulation of peptidase activityGO:00525471800.015
modification dependent protein catabolic processGO:00199412090.015
Mouse
regulation of cell differentiationGO:00455953930.015
regulation of testosterone biosynthetic processGO:200022420.015
circadian behaviorGO:004851220.015
regulation of cell migrationGO:00303342890.015
regulation of establishment of protein localizationGO:00702012420.015
positive regulation of reactive oxygen species biosynthetic processGO:190342820.015
positive regulation of protein kinase activityGO:00458601900.015
regulation of nucleotide metabolic processGO:00061402690.015
positive regulation of gtp catabolic processGO:00331261660.015
regulation of cytoskeleton organizationGO:00514931770.015
negative regulation of cell proliferationGO:00082852280.015
associative learningGO:000830610.015
neural tube formationGO:000184130.015
regulation of hormone levelsGO:00108171250.015
cation transmembrane transportGO:00986552380.014
protein localization to organelleGO:00333652800.014
regulation of small gtpase mediated signal transductionGO:00510561560.014
compound eye developmentGO:004874910.014
limbic system developmentGO:002176130.014
response to organonitrogen compoundGO:00102431560.014
positive regulation of synaptic transmissionGO:005080640.014
unsaturated fatty acid metabolic processGO:0033559370.014
lipid catabolic processGO:0016042840.014
regulation of protein transportGO:00512232130.014
response to radiationGO:00093141510.014
cell growthGO:00160491600.014
hemopoiesisGO:00300971800.014
negative regulation of transportGO:00510511760.014
rna interferenceGO:001624640.014
regulation of cell adhesionGO:00301551660.014
monocarboxylic acid biosynthetic processGO:0072330670.014
negative regulation of phosphorylationGO:00423261740.013
negative regulation of protein phosphorylationGO:00019331400.013
enzyme linked receptor protein signaling pathwayGO:00071673030.013
regulation of protein maturationGO:19033171500.013
protein importGO:00170381300.013
regulation of secretionGO:00510461940.013
regulation of protein processingGO:00706131500.013
tube closureGO:006060630.013
regulation of i kappab kinase nf kappab signalingGO:00431221620.013
immune effector processGO:00022521590.013
neurological system processGO:00508771630.013
glycoprotein metabolic processGO:00091001100.013
motor neuron axon guidanceGO:000804520.013
positive regulation of proteolysisGO:00458621420.013
Mouse
alcohol metabolic processGO:00060661140.013
regulation of locomotionGO:00400123290.013
cellular response to endogenous stimulusGO:00714953360.013
lipid biosynthetic processGO:00086101770.013
protein processingGO:00164852260.013
matingGO:000761810.013
cell fate determinationGO:000170930.013
carbohydrate derivative biosynthetic processGO:19011372070.013
response to fungusGO:000962040.013
reactive nitrogen species metabolic processGO:200105730.013
regulation of vesicle mediated transportGO:00606271300.013
cellular response to lipidGO:00713961270.013
negative regulation of proteolysisGO:00458611320.013
wnt signaling pathwayGO:00160551560.013
rab protein signal transductionGO:003248240.013
negative regulation of multicellular organismal processGO:00512413170.013
mitotic cell cycle phase transitionGO:00447721620.013
interspecies interaction between organismsGO:00444191560.013
nucleocytoplasmic transportGO:00069131760.013
regulation of endopeptidase activityGO:00525481700.013
inorganic cation transmembrane transportGO:00986621940.013
regulation of neural precursor cell proliferationGO:200017740.013
positive regulation of gtpase activityGO:00435471660.013
single organism cell adhesionGO:00986021790.013
response to nitrogen compoundGO:19016981840.012
hematopoietic or lymphoid organ developmentGO:00485341860.012
secretion by cellGO:00329402260.012
cellular divalent inorganic cation homeostasisGO:00725031280.012
neurotransmitter secretionGO:000726940.012
tissue regenerationGO:004224630.012
neurogenesisGO:00220081690.012
neural tube closureGO:000184330.012
cellular response to external stimulusGO:00714961110.012
testosterone biosynthetic processGO:006137020.012
myeloid cell differentiationGO:00300991170.012
somitogenesisGO:000175620.012
primary neural tube formationGO:001402030.012
positive regulation of ras gtpase activityGO:00323201170.012
symbiosis encompassing mutualism through parasitismGO:00444031560.012
cellular chemical homeostasisGO:00550821800.012
regulation of dna metabolic processGO:00510521530.012
plasma membrane organizationGO:00070091150.012
cell cycle phase transitionGO:00447701730.012
nuclear transportGO:00511691790.012
protein acylationGO:00435431380.012
cell substrate adhesionGO:00315891320.012
cell projection assemblyGO:00300311260.012
behavioral response to ethanolGO:004814920.012
nucleus localizationGO:005164710.012
multi organism cellular processGO:00447641560.012
positive regulation of cytokine productionGO:00018191670.012
regulation of reactive oxygen species metabolic processGO:2000377410.012
intrinsic apoptotic signaling pathwayGO:00971931270.012
single organism reproductive processGO:0044702980.012
protein glycosylationGO:0006486620.012
peptide biosynthetic processGO:004304380.012
cardiac muscle cell contractionGO:008600340.012
organic acid catabolic processGO:0016054710.012
establishment or maintenance of bipolar cell polarityGO:006124520.012
regulation of immune responseGO:00507762010.012
syncytium formation by plasma membrane fusionGO:000076820.012
atp catabolic processGO:00062001570.012
nitrogen compound transportGO:00717051910.012
regulation of cytoplasmic transportGO:19036491490.012
epithelial cell differentiationGO:00308551410.012
epithelium developmentGO:00604292270.012
response to reactive oxygen speciesGO:0000302610.012
Worm
regulation of synaptic plasticityGO:004816730.012
sequestering of metal ionGO:0051238240.012
cellular protein complex assemblyGO:00436231880.012
chromatin modificationGO:00165682980.012
positive regulation of cell differentiationGO:00455972110.012
regulation of wnt signaling pathwayGO:00301111230.012
establishment or maintenance of apical basal cell polarityGO:003508820.012
negative regulation of cell cycleGO:00457861930.012
anion transmembrane transportGO:0098656760.012
modification dependent macromolecule catabolic processGO:00436322120.012
Mouse
negative regulation of cell growthGO:0030308830.011
regulation of ras gtpase activityGO:00323181280.011
regulation of ion transportGO:00432691890.011
chromatin organizationGO:00063253510.011
glycosylationGO:0070085710.011
morphogenesis of a polarized epitheliumGO:000173830.011
regulation of cell morphogenesisGO:00226041530.011
neural crest cell developmentGO:001403230.011
cell activationGO:00017752130.011
salivary gland morphogenesisGO:000743540.011
nerve developmentGO:002167540.011
actin mediated cell contractionGO:0070252120.011
negative regulation of synaptic transmissionGO:005080520.011
viral processGO:00160321460.011
organ morphogenesisGO:00098871470.011
posttranscriptional regulation of gene expressionGO:00106082130.011
immune system developmentGO:00025201950.011
inner ear morphogenesisGO:004247240.011
regulation of nucleoside metabolic processGO:00091182090.011
regulation of intracellular protein transportGO:00331571230.011
carboxylic acid transportGO:0046942630.011
response to axon injuryGO:004867810.011
negative regulation of transferase activityGO:00513481240.011
metencephalon developmentGO:002203720.011
sensory perception of painGO:001923340.011
response to salt stressGO:000965130.011
actin cytoskeleton organizationGO:00300362070.011
cellular response to hormone stimulusGO:00328701250.011
protein autophosphorylationGO:00467771230.011
guanosine containing compound catabolic processGO:19010692390.011
response to woundingGO:00096111680.011
neuroblast proliferationGO:000740540.011
negative regulation of endopeptidase activityGO:0010951840.011
cellular response to growth factor stimulusGO:00713631970.011
negative regulation of protein maturationGO:19033181420.011
negative regulation of catabolic processGO:00098951040.011
regulation of protein complex assemblyGO:00432541470.011
canonical wnt signaling pathwayGO:00600701160.011
cellular lipid catabolic processGO:0044242650.011
regulation of cell cycle processGO:00105642660.011
response to extracellular stimulusGO:0009991850.011
cell part morphogenesisGO:00329901370.011
positive regulation of immune responseGO:00507781590.011
cellular response to extracellular stimulusGO:0031668720.011
negative regulation of kinase activityGO:00336731060.011
sequestering of calcium ionGO:0051208170.011
prostate gland developmentGO:003085030.011
engulfment of apoptotic cellGO:004365220.011
regulation of gtp catabolic processGO:00331241800.011
organic acid transportGO:0015849650.011
regulation of defense responseGO:00313471540.011
cell projection morphogenesisGO:00488581290.011
release of cytoplasmic sequestered nf kappabGO:000858840.010
glycoprotein biosynthetic processGO:0009101910.010
receptor metabolic processGO:0043112810.010
long term memoryGO:000761620.010
response to lipidGO:00339932060.010
nuclear importGO:00511701060.010
protein localization to nucleusGO:00345041360.010
negative regulation of protein processingGO:00109551420.010
golgi vesicle transportGO:0048193800.010
positive regulation of cellular component biogenesisGO:00440891580.010
regulation of cysteine type endopeptidase activityGO:20001161270.010
positive regulation of cell migrationGO:00303351720.010
regulation of mitotic cell cycleGO:00073461890.010
spinal cord developmentGO:002151040.010
peptidyl lysine modificationGO:00182051440.010
meiosis iGO:000712740.010
protein import into nucleusGO:00066061040.010
visual behaviorGO:000763220.010
glycerolipid metabolic processGO:00464861070.010
hippocampus developmentGO:002176610.010
carboxylic acid catabolic processGO:0046395710.010
developmental programmed cell deathGO:001062330.010

GCLC disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.055
cancerDOID:1621670.028
disease of cellular proliferationDOID:145661740.028
inherited metabolic disorderDOID:6552420.027
nervous system diseaseDOID:8634310.027
central nervous system diseaseDOID:3311860.027
organ system cancerDOID:00506861640.020
musculoskeletal system diseaseDOID:172230.019
sensory system diseaseDOID:00501552030.019
eye and adnexa diseaseDOID:14921500.016
eye diseaseDOID:56141490.016
amino acid metabolic disorderDOID:9252500.014
immune system diseaseDOID:29141550.014
muscular diseaseDOID:00800001140.013
connective tissue diseaseDOID:651090.012
bone diseaseDOID:0080001880.012
hematopoietic system diseaseDOID:741000.012
muscle tissue diseaseDOID:661130.012
myopathyDOID:4231040.012
neurodegenerative diseaseDOID:12891020.011
carbohydrate metabolic disorderDOID:2978550.011
retinal diseaseDOID:56791180.011
cardiovascular system diseaseDOID:12871060.011