Homo sapiens

0 known processes

GPX4

glutathione peroxidase 4 (phospholipid hydroperoxidase)

(Aliases: MCSP,PHGPx,snPHGPx,snGPx)

GPX4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
glutathione metabolic processGO:0006749200.460
oxidation reduction processGO:00551143960.440
reactive oxygen species metabolic processGO:0072593750.434
negative regulation of cell deathGO:00605483450.356
response to oxygen containing compoundGO:19017003690.220
regulation of endopeptidase activityGO:00525481700.219
post embryonic developmentGO:000979120.206
negative regulation of catalytic activityGO:00430863350.195
determination of adult lifespanGO:000834020.173
mitochondrion organizationGO:00070051560.159
cellular response to reactive oxygen speciesGO:0034614500.158
negative regulation of apoptotic processGO:00430663160.154
regulation of protein catabolic processGO:00421761550.139
cellular response to hydrogen peroxideGO:0070301370.139
hydrogen peroxide metabolic processGO:0042743200.132
cellular response to oxygen containing compoundGO:19017012760.128
negative regulation of protein metabolic processGO:00512483910.119
regulation of peptidase activityGO:00525471800.110
response to oxidative stressGO:00069791210.110
response to inorganic substanceGO:00100351270.108
hydrogen peroxide catabolic processGO:0042744130.103
cellular lipid metabolic processGO:00442553030.102
negative regulation of cellular protein metabolic processGO:00322693530.095
cellular response to oxidative stressGO:0034599850.094
protein processingGO:00164852260.094
response to reactive oxygen speciesGO:0000302610.092
protein maturationGO:00516042330.090
negative regulation of programmed cell deathGO:00430693210.089
detection of muramyl dipeptideGO:003249810.087
response to hydrogen peroxideGO:0042542400.085
regulation of cysteine type endopeptidase activityGO:20001161270.083
lipid metabolic processGO:00066293810.082
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.079
cellular amino acid metabolic processGO:00065201160.078
regulation of protein maturationGO:19033171500.077
bleb assemblyGO:003206060.074
negative regulation of cysteine type endopeptidase activityGO:2000117480.074
transmembrane transportGO:00550853990.072
response to abiotic stimulusGO:00096283360.068
negative regulation of apoptotic signaling pathwayGO:2001234970.066
membrane organizationGO:00610242920.066
release of cytochrome c from mitochondriaGO:0001836350.065
phospholipid metabolic processGO:0006644990.064
mitotic cell cycleGO:00002783260.063
multicellular organismal agingGO:001025930.060
regulation of protein processingGO:00706131500.060
cellular protein catabolic processGO:00442572610.058
lipid catabolic processGO:0016042840.057
negative regulation of protein maturationGO:19033181420.055
proteolysis involved in cellular protein catabolic processGO:00516032440.055
inorganic cation transmembrane transportGO:00986621940.053
cation transportGO:00068123310.053
negative regulation of peptidase activityGO:0010466910.051
protein catabolic processGO:00301633250.051
regulation of cellular component biogenesisGO:00440872810.050
system processGO:00030083490.049
cellular homeostasisGO:00197251960.049
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043154460.048
positive regulation of cell deathGO:00109422630.047
cellular lipid catabolic processGO:0044242650.047
positive regulation of phosphorylationGO:00423273940.046
cellular ketone metabolic processGO:0042180800.046
mapk cascadeGO:00001652880.045
positive regulation of kinase activityGO:00336742040.045
vesicle mediated transportGO:00161923710.045
cellular amide metabolic processGO:0043603690.045
positive regulation of cellular amine metabolic processGO:003324070.044
cellular modified amino acid metabolic processGO:0006575640.043
regulation of mitochondrion organizationGO:0010821540.043
signal transduction by phosphorylationGO:00230142970.043
negative regulation of proteolysisGO:00458611320.042
regulation of cellular protein catabolic processGO:1903362960.042
phospholipid catabolic processGO:0009395120.042
regulation of mapk cascadeGO:00434082620.041
negative regulation of hydrolase activityGO:00513461820.039
inorganic ion transmembrane transportGO:00986602310.038
regulation of body fluid levelsGO:0050878990.038
organonitrogen compound biosynthetic processGO:19015662000.037
protein localization to organelleGO:00333652800.036
positive regulation of transportGO:00510503360.035
wnt signaling pathwayGO:00160551560.035
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.035
mitochondrial transportGO:0006839600.034
response to lipidGO:00339932060.034
carbohydrate derivative biosynthetic processGO:19011372070.034
extrinsic apoptotic signaling pathwayGO:00971911190.034
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.033
regulation of cell cycleGO:00517263930.033
negative regulation of endopeptidase activityGO:0010951840.033
blood coagulationGO:0007596760.033
regulation of proteolysisGO:00301622930.033
cellular macromolecular complex assemblyGO:00346223240.033
regulation of transferase activityGO:00513383550.032
positive regulation of mapk cascadeGO:00434101900.032
regulation of proteasomal protein catabolic processGO:0061136870.032
intracellular protein transportGO:00068862700.032
regulation of reactive oxygen species metabolic processGO:2000377410.032
regulation of sequence specific dna binding transcription factor activityGO:00510902110.031
negative regulation of phosphorus metabolic processGO:00105632670.031
apoptotic signaling pathwayGO:00971902680.031
small molecule biosynthetic processGO:00442831570.030
peptide metabolic processGO:0006518510.030
positive regulation of cell proliferationGO:00082843010.029
carbohydrate metabolic processGO:00059752070.029
negative regulation of protein processingGO:00109551420.029
single organism cellular localizationGO:19025803320.029
proteasomal protein catabolic processGO:00104981760.029
epithelial cell proliferationGO:00506731280.029
regulation of cell motilityGO:20001452990.029
regulation of apoptotic signaling pathwayGO:20012331750.028
regulation of cell differentiationGO:00455953930.028
cytoplasmic transportGO:00164823790.027
positive regulation of cellular component biogenesisGO:00440891580.027
ion transmembrane transportGO:00342203380.027
regulation of canonical wnt signaling pathwayGO:0060828880.027
positive regulation of developmental processGO:00510943140.027
negative regulation of multicellular organismal processGO:00512413170.026
regulation of wnt signaling pathwayGO:00301111230.026
positive regulation of catabolic processGO:00098963100.026
regulation of kinase activityGO:00435493140.026
hemostasisGO:0007599760.026
canonical wnt signaling pathwayGO:00600701160.025
regulation of cellular amine metabolic processGO:0033238110.025
response to bacteriumGO:00096171440.025
response to woundingGO:00096111680.025
regulation of mitotic cell cycleGO:00073461890.025
positive regulation of protein phosphorylationGO:00019343130.025
negative regulation of cellular component organizationGO:00511292350.024
heart contractionGO:0060047620.024
coenzyme metabolic processGO:0006732650.024
immune responseGO:00069553070.024
positive regulation of protein kinase activityGO:00458601900.023
positive regulation of programmed cell deathGO:00430682490.023
modification dependent macromolecule catabolic processGO:00436322120.023
single organism membrane organizationGO:00448022680.023
microtubule cytoskeleton organizationGO:00002261760.023
mitotic cell cycle processGO:19030472860.023
regulation of anatomical structure morphogenesisGO:00226032860.023
positive regulation of hydrolase activityGO:00513453310.023
heart processGO:0003015620.023
ras protein signal transductionGO:0007265730.022
positive regulation of transferase activityGO:00513472270.022
enzyme linked receptor protein signaling pathwayGO:00071673030.022
regulation of protein kinase activityGO:00458592890.022
protein targetingGO:00066051870.022
epithelium developmentGO:00604292270.022
response to hormoneGO:00097251750.021
single organism carbohydrate metabolic processGO:00447231930.021
regulation of purine nucleotide metabolic processGO:19005422640.021
neuroblast proliferationGO:000740540.021
regenerationGO:003109940.021
response to cytokineGO:00340972320.021
positive regulation of cellular amino acid metabolic processGO:004576430.021
female gamete generationGO:000729220.021
response to biotic stimulusGO:00096072760.021
thymus developmentGO:004853830.021
positive regulation of cellular component organizationGO:00511303760.021
cell activationGO:00017752130.021
regulation of immune responseGO:00507762010.020
cell projection assemblyGO:00300311260.020
negative regulation of organelle organizationGO:00106391260.020
defense responseGO:00069523150.020
organophosphate catabolic processGO:00464344300.020
wound healingGO:00420601150.020
organophosphate biosynthetic processGO:00904071630.020
cellular macromolecule catabolic processGO:00442653800.020
protein ubiquitinationGO:00165673140.020
negative regulation of phosphate metabolic processGO:00459362670.020
regulation of epithelial cell proliferationGO:00506781130.020
coagulationGO:0050817780.020
mitochondrial membrane organizationGO:0007006400.019
negative regulation of protein modification processGO:00314002000.019
oxidoreduction coenzyme metabolic processGO:0006733190.019
regulation of map kinase activityGO:00434051080.019
cation transmembrane transportGO:00986552380.019
secretion by cellGO:00329402260.019
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.019
regulation of glomerulus developmentGO:009019230.019
response to light stimulusGO:0009416870.018
regulation of cellular amino acid metabolic processGO:000652160.018
positive regulation of cellular component movementGO:00512721810.018
regulation of protein localizationGO:00328802960.018
endomembrane system organizationGO:00102561960.018
regulation of protein serine threonine kinase activityGO:00719001790.018
cellular response to lipidGO:00713961270.018
erk1 and erk2 cascadeGO:00703711040.018
positive regulation of immune system processGO:00026842830.018
cellular protein complex assemblyGO:00436231880.018
cellular cation homeostasisGO:00300031630.018
positive regulation of locomotionGO:00400171860.017
secretionGO:00469032540.017
divalent inorganic cation transportGO:00725111580.017
protein deubiquitinationGO:0016579790.017
response to oxygen levelsGO:00704821000.017
positive regulation of protein catabolic processGO:0045732750.017
activation of protein kinase activityGO:0032147900.017
response to hypoxiaGO:0001666960.017
segmentationGO:003528240.017
regulation of cell cycle processGO:00105642660.017
positive regulation of protein serine threonine kinase activityGO:00719021190.017
reactive nitrogen species metabolic processGO:200105730.017
organic acid biosynthetic processGO:0016053970.016
regulation of secretionGO:00510461940.016
regulation of erk1 and erk2 cascadeGO:0070372990.016
response to mercury ionGO:004668940.016
response to molecule of bacterial originGO:0002237820.016
calcium ion transportGO:00068161470.016
cell adhesionGO:00071553250.016
regulation of response to woundingGO:19030341010.016
cardiac muscle cell contractionGO:008600340.016
single organism cell adhesionGO:00986021790.016
regulation of locomotionGO:00400123290.016
apoptotic mitochondrial changesGO:0008637570.016
regulation of cellular component movementGO:00512703340.016
cellular chemical homeostasisGO:00550821800.016
tissue homeostasisGO:0001894630.016
modification dependent protein catabolic processGO:00199412090.016
cofactor metabolic processGO:0051186870.015
purine ribonucleoside metabolic processGO:00461284370.015
embryo developmentGO:00097901230.015
ribonucleoside triphosphate metabolic processGO:00091994120.015
endocytosisGO:00068971590.015
cellular response to cytokine stimulusGO:00713451810.015
regulation of cellular ketone metabolic processGO:0010565500.015
microtubule based processGO:00070172100.015
regulation of ion transmembrane transportGO:00347651320.015
cell growthGO:00160491600.015
regulation of cell activationGO:00508651250.014
cellular response to endogenous stimulusGO:00714953360.014
maintenance of location in cellGO:0051651620.014
negative regulation of intracellular signal transductionGO:19025321830.014
peptidyl serine modificationGO:00182091060.014
pyridine nucleotide metabolic processGO:0019362140.014
regulation of ras protein signal transductionGO:00465781550.014
adult locomotory behaviorGO:000834410.014
establishment of protein localization to organelleGO:00725941720.014
cell projection organizationGO:00300302520.014
peptidyl tyrosine modificationGO:00182121700.014
negative regulation of transferase activityGO:00513481240.014
small molecule catabolic processGO:0044282920.014
metencephalon developmentGO:002203720.014
central nervous system developmentGO:00074171230.014
anatomical structure homeostasisGO:00602491000.014
response to other organismGO:00517072610.014
positive regulation of secretion by cellGO:19035321080.014
maintenance of locationGO:00512351120.013
posttranscriptional regulation of gene expressionGO:00106082130.013
multicellular organismal homeostasisGO:0048871670.013
regulation of neural precursor cell proliferationGO:200017740.013
amine metabolic processGO:0009308440.013
circulatory system processGO:00030131130.013
cellular response to nitrogen compoundGO:19016991440.013
peptidyl serine phosphorylationGO:00181051010.013
establishment of protein localization to membraneGO:00901501210.013
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625420.013
positive regulation of proteolysisGO:00458621420.013
regulation of protein transportGO:00512232130.013
protein localization to membraneGO:00726571600.013
response to decreased oxygen levelsGO:0036293960.013
regulation of growthGO:00400081650.013
negative regulation of cell proliferationGO:00082852280.013
nucleotide biosynthetic processGO:00091651090.013
hematopoietic or lymphoid organ developmentGO:00485341860.013
purine nucleotide catabolic processGO:00061954050.013
protein homooligomerizationGO:00512601000.013
mitochondrial respiratory chain complex assemblyGO:0033108230.013
divalent metal ion transportGO:00708381520.013
positive regulation of necrotic cell deathGO:001094040.012
biological adhesionGO:00226103310.012
energy derivation by oxidation of organic compoundsGO:0015980430.012
rna interferenceGO:001624640.012
positive regulation of reactive oxygen species metabolic processGO:2000379240.012
epithelial cell migrationGO:00106311190.012
hexose metabolic processGO:0019318550.012
nadph oxidationGO:007099530.012
innate immune responseGO:00450871780.012
positive regulation of cell differentiationGO:00455972110.012
metal ion transportGO:00300012720.012
response to drugGO:0042493810.012
response to metal ionGO:0010038840.012
negative regulation of cell cycleGO:00457861930.012
positive regulation of organelle organizationGO:00106381950.012
regulation of gene expression epigeneticGO:0040029730.012
epithelial cell differentiationGO:00308551410.012
regulation of cellular response to stressGO:00801352440.012
acetylcholine transportGO:001587010.012
fibroblast proliferationGO:0048144330.012
cell substrate adhesionGO:00315891320.012
negative regulation of wnt signaling pathwayGO:0030178690.012
sequestering of metal ionGO:0051238240.011
negative regulation of growthGO:0045926970.011
regulation of mhc class i biosynthetic processGO:004534340.011
immune effector processGO:00022521590.011
autophagyGO:0006914880.011
protein oligomerizationGO:00512591730.011
regulation of multi organism processGO:00439001570.011
tissue regenerationGO:004224630.011
purine containing compound biosynthetic processGO:0072522880.011
regulation of wound healingGO:0061041560.011
response to axon injuryGO:004867810.011
response to external biotic stimulusGO:00432072610.011
purine containing compound catabolic processGO:00725234110.011
dephosphorylationGO:00163112090.011
purine ribonucleoside triphosphate metabolic processGO:00092054110.011
protein localization to plasma membraneGO:0072659930.011
cellular metal ion homeostasisGO:00068751460.011
regulation of protein modification by small protein conjugation or removalGO:19033201070.011
sex differentiationGO:0007548450.011
positive regulation of secretionGO:00510471160.011
regulation of response to external stimulusGO:00321012220.011
chemical homeostasisGO:00488783060.011
cation homeostasisGO:00550801890.011
regulation of chromosome organizationGO:00330441030.011
negative regulation of cell growthGO:0030308830.011
regulation of nucleotide metabolic processGO:00061402690.011
striated muscle contractionGO:0006941520.011
platelet activationGO:0030168440.010
compound eye developmentGO:004874910.010
actin filament based processGO:00300292240.010
regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:1902041240.010
single organism reproductive processGO:0044702980.010
purine ribonucleoside monophosphate metabolic processGO:00091671860.010
negative regulation of cell cycle phase transitionGO:1901988890.010
regulation of cell growthGO:00015581350.010
reproductive system developmentGO:0061458560.010
regulation of cell cycle phase transitionGO:19019871260.010
negative regulation of response to external stimulusGO:0032102830.010
nucleoside phosphate catabolic processGO:19012924120.010
cellular amine metabolic processGO:0044106410.010
mitotic cell cycle phase transitionGO:00447721620.010

GPX4 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.044
cancerDOID:1621670.019
disease of cellular proliferationDOID:145661740.019
disease of mental healthDOID:150700.013
central nervous system diseaseDOID:3311860.012
nervous system diseaseDOID:8634310.012
eye diseaseDOID:56141490.011
sensory system diseaseDOID:00501552030.011
eye and adnexa diseaseDOID:14921500.011