Homo sapiens

0 known processes

EFR3B

EFR3 homolog B (S. cerevisiae)

(Aliases: KIAA0953)

EFR3B biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
ion transmembrane transportGO:00342203380.171
regulation of cellular ketone metabolic processGO:0010565500.139
regulation of purine nucleotide metabolic processGO:19005422640.138
amine metabolic processGO:0009308440.124
cellular ketone metabolic processGO:0042180800.121
regulation of cellular amine metabolic processGO:0033238110.111
cellular amine metabolic processGO:0044106410.109
cation transportGO:00068123310.106
cell developmentGO:00484683280.104
regulation of cellular amino acid metabolic processGO:000652160.101
ribonucleoside triphosphate catabolic processGO:00092033910.096
nucleoside triphosphate catabolic processGO:00091433940.091
transmembrane transportGO:00550853990.089
ribonucleotide catabolic processGO:00092614050.085
locomotory behaviorGO:000762610.085
purine nucleoside triphosphate catabolic processGO:00091463920.084
positive regulation of cellular amino acid metabolic processGO:004576430.082
ras protein signal transductionGO:0007265730.081
small gtpase mediated signal transductionGO:0007264780.078
inorganic ion transmembrane transportGO:00986602310.077
purine ribonucleotide catabolic processGO:00091544040.076
regulation of nucleotide metabolic processGO:00061402690.076
positive regulation of cellular amine metabolic processGO:003324070.075
cellular amino acid metabolic processGO:00065201160.075
post embryonic developmentGO:000979120.074
ribonucleoside triphosphate metabolic processGO:00091994120.072
system processGO:00030083490.072
chemical homeostasisGO:00488783060.071
muscle contractionGO:0006936730.071
purine nucleotide catabolic processGO:00061954050.071
metal ion transportGO:00300012720.071
nervous system developmentGO:00073992930.070
purine nucleoside catabolic processGO:00061523980.069
inorganic cation transmembrane transportGO:00986621940.069
nucleoside triphosphate metabolic processGO:00091414220.068
positive regulation of phosphorylationGO:00423273940.068
nucleotide catabolic processGO:00091664080.068
purine ribonucleoside triphosphate metabolic processGO:00092054110.066
cell morphogenesisGO:00009022960.065
purine ribonucleoside triphosphate catabolic processGO:00092073910.065
organophosphate catabolic processGO:00464344300.063
purine ribonucleoside catabolic processGO:00461303980.062
purine containing compound catabolic processGO:00725234110.062
cation transmembrane transportGO:00986552380.061
glycosyl compound catabolic processGO:19016584130.059
regulation of ion transportGO:00432691890.059
positive regulation of cellular component organizationGO:00511303760.059
gtp catabolic processGO:00061842370.057
purine ribonucleoside metabolic processGO:00461284370.057
cytoplasmic transportGO:00164823790.057
nucleoside catabolic processGO:00091644080.056
regulation of nucleotide catabolic processGO:00308112050.056
cellular component morphogenesisGO:00329893140.055
ribonucleoside catabolic processGO:00424544060.054
regulation of gtp catabolic processGO:00331241800.054
positive regulation of protein phosphorylationGO:00019343130.053
nucleoside phosphate catabolic processGO:19012924120.053
divalent inorganic cation homeostasisGO:00725071360.052
guanosine containing compound catabolic processGO:19010692390.052
cellular homeostasisGO:00197251960.050
regulation of ion transmembrane transportGO:00347651320.050
gtp metabolic processGO:00460392390.049
cellular chemical homeostasisGO:00550821800.048
regulation of metal ion transportGO:00109591200.048
guanosine containing compound metabolic processGO:19010682440.048
purine nucleoside triphosphate metabolic processGO:00091444120.048
regulation of nucleoside metabolic processGO:00091182090.047
actin filament based processGO:00300292240.047
membrane organizationGO:00610242920.046
single organism membrane organizationGO:00448022680.046
cell projection organizationGO:00300302520.046
regulation of transferase activityGO:00513383550.046
positive regulation of nucleotide metabolic processGO:00459812300.045
ion homeostasisGO:00508012300.045
regulation of kinase activityGO:00435493140.045
cellular response to endogenous stimulusGO:00714953360.045
regulation of purine nucleotide catabolic processGO:00331212050.044
calcium ion transportGO:00068161470.044
positive regulation of hydrolase activityGO:00513453310.044
cell adhesionGO:00071553250.044
cellular cation homeostasisGO:00300031630.043
positive regulation of cellular catabolic processGO:00313312840.043
rho protein signal transductionGO:0007266260.043
positive regulation of purine nucleotide metabolic processGO:19005442270.042
negative regulation of catalytic activityGO:00430863350.042
regulation of protein kinase activityGO:00458592890.041
regulation of transmembrane transportGO:00347621390.040
g protein coupled receptor signaling pathwayGO:00071862070.040
memoryGO:000761330.039
neurological system processGO:00508771630.039
positive regulation of catabolic processGO:00098963100.039
regulation of locomotionGO:00400123290.039
single organism cellular localizationGO:19025803320.039
regulation of cell motilityGO:20001452990.039
regulation of gtpase activityGO:00430871800.039
positive regulation of nucleoside metabolic processGO:00459791860.037
biological adhesionGO:00226103310.037
neuromuscular junction developmentGO:000752830.037
female gamete generationGO:000729220.037
positive regulation of nucleotide catabolic processGO:00308131850.036
neurogenesisGO:00220081690.036
positive regulation of purine nucleotide catabolic processGO:00331231850.036
regulation of cell migrationGO:00303342890.035
regulation of synaptic plasticityGO:004816730.035
response to oxygen containing compoundGO:19017003690.035
multicellular organismal agingGO:001025930.035
regulation of anatomical structure morphogenesisGO:00226032860.035
generation of neuronsGO:00486991520.035
secretion by cellGO:00329402260.035
positive regulation of gtpase activityGO:00435471660.034
positive regulation of gtp catabolic processGO:00331261660.034
oogenesisGO:004847720.034
negative regulation of phosphate metabolic processGO:00459362670.034
divalent inorganic cation transportGO:00725111580.034
regulation of protein localizationGO:00328802960.033
cellular ion homeostasisGO:00068731680.033
metal ion homeostasisGO:00550651690.033
response to abiotic stimulusGO:00096283360.033
mapk cascadeGO:00001652880.032
cellular metal ion homeostasisGO:00068751460.032
positive regulation of synaptic transmissionGO:005080640.032
calcium ion homeostasisGO:00550741220.031
regulation of cellular component biogenesisGO:00440872810.031
regulation of membrane potentialGO:0042391950.031
positive regulation of transportGO:00510503360.031
negative regulation of cellular protein metabolic processGO:00322693530.031
regulation of cellular component movementGO:00512703340.030
divalent metal ion transportGO:00708381520.030
vesicle mediated transportGO:00161923710.030
positive regulation of cell migrationGO:00303351720.029
negative regulation of cell deathGO:00605483450.029
regulation of establishment of protein localizationGO:00702012420.029
cytosolic calcium ion homeostasisGO:0051480890.029
regulation of cell differentiationGO:00455953930.029
determination of adult lifespanGO:000834020.029
secretionGO:00469032540.029
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188430.029
positive regulation of cell motilityGO:20001471770.028
positive regulation of transferase activityGO:00513472270.028
protein catabolic processGO:00301633250.028
positive regulation of ras gtpase activityGO:00323201170.028
positive regulation of protein kinase activityGO:00458601900.028
behaviorGO:00076101120.028
cation homeostasisGO:00550801890.028
neuron differentiationGO:00301821380.027
signal transduction by phosphorylationGO:00230142970.027
cellular response to oxygen containing compoundGO:19017012760.027
response to radiationGO:00093141510.027
nucleotide biosynthetic processGO:00091651090.027
cell part morphogenesisGO:00329901370.027
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187430.027
negative regulation of programmed cell deathGO:00430693210.026
regulation of cell developmentGO:00602841610.026
neurotransmitter secretionGO:000726940.026
endomembrane system organizationGO:00102561960.026
motor neuron axon guidanceGO:000804520.026
cellular calcium ion homeostasisGO:00068741170.026
cardiac muscle cell contractionGO:008600340.026
positive regulation of cell proliferationGO:00082843010.026
cell cell signalingGO:00072671550.026
negative regulation of phosphorus metabolic processGO:00105632670.026
negative regulation of transportGO:00510511760.026
negative regulation of protein metabolic processGO:00512483910.026
intracellular protein transportGO:00068862700.025
regulation of proteolysisGO:00301622930.025
cellular potassium ion transportGO:0071804600.025
positive regulation of cellular component movementGO:00512721810.025
associative learningGO:000830610.025
positive regulation of developmental processGO:00510943140.025
regulation of secretion by cellGO:19035301770.025
cell growthGO:00160491600.025
regulation of small gtpase mediated signal transductionGO:00510561560.025
organonitrogen compound biosynthetic processGO:19015662000.025
regulation of intracellular transportGO:00323861950.024
positive regulation of cytosolic calcium ion concentrationGO:0007204820.024
protein ubiquitinationGO:00165673140.024
mitotic cell cycleGO:00002783260.024
regulation of cell morphogenesisGO:00226041530.024
regulation of response to external stimulusGO:00321012220.024
potassium ion transmembrane transportGO:0071805600.024
regulation of ras protein signal transductionGO:00465781550.024
growthGO:00400072020.024
segmentationGO:003528240.024
response to nitrogen compoundGO:19016981840.024
regulation of protein transportGO:00512232130.024
response to organic cyclic compoundGO:00140702040.024
monovalent inorganic cation transportGO:00156721280.023
neuron projection developmentGO:00311751060.023
dephosphorylationGO:00163112090.023
negative regulation of hydrolase activityGO:00513461820.023
muscle system processGO:0003012810.023
regulation of cyclase activityGO:0031279190.023
regulation of transmembrane transporter activityGO:0022898740.023
purine ribonucleotide biosynthetic processGO:0009152790.023
regulation of ras gtpase activityGO:00323181280.023
positive regulation of kinase activityGO:00336742040.023
regenerationGO:003109940.023
response to growth factorGO:00708482050.023
negative regulation of apoptotic processGO:00430663160.023
cell projection morphogenesisGO:00488581290.023
regulation of cell growthGO:00015581350.023
cellular macromolecular complex assemblyGO:00346223240.023
taxisGO:00423301570.022
cellular response to dna damage stimulusGO:00069743790.022
cellular response to growth factor stimulusGO:00713631970.022
cellular divalent inorganic cation homeostasisGO:00725031280.022
lipid metabolic processGO:00066293810.022
cell morphogenesis involved in differentiationGO:00009041440.022
regulation of secretionGO:00510461940.022
camp metabolic processGO:0046058610.022
cellular macromolecule catabolic processGO:00442653800.022
regulation of neurotransmitter secretionGO:004692830.022
carbohydrate derivative biosynthetic processGO:19011372070.022
regulation of ion transmembrane transporter activityGO:0032412720.022
enzyme linked receptor protein signaling pathwayGO:00071673030.022
protein modification by small protein conjugationGO:00324463420.022
nucleoside phosphate biosynthetic processGO:19012931090.022
response to lipidGO:00339932060.022
protein localization to membraneGO:00726571600.022
regulation of mapk cascadeGO:00434082620.022
positive regulation of mapk cascadeGO:00434101900.022
negative regulation of cellular component organizationGO:00511292350.022
single organism cell adhesionGO:00986021790.022
regulation of cytoskeleton organizationGO:00514931770.022
protein localization to organelleGO:00333652800.021
blastoderm segmentationGO:000735020.021
negative regulation of developmental processGO:00510932470.021
positive regulation of locomotionGO:00400171860.021
organophosphate biosynthetic processGO:00904071630.021
ribose phosphate biosynthetic processGO:0046390820.021
regulation of growthGO:00400081650.021
regulation of cell cycle processGO:00105642660.021
organ formationGO:004864530.021
cyclic nucleotide biosynthetic processGO:0009190610.021
regulation of cellular response to stressGO:00801352440.020
neuroblast proliferationGO:000740540.020
mitotic cell cycle processGO:19030472860.020
adult locomotory behaviorGO:000834410.020
regulation of cell cycleGO:00517263930.020
protein targetingGO:00066051870.020
cellular protein catabolic processGO:00442572610.020
purine containing compound biosynthetic processGO:0072522880.020
potassium ion transportGO:0006813620.020
maintenance of locationGO:00512351120.020
sensory perception of light stimulusGO:0050953350.020
synaptic transmissionGO:0007268610.020
negative regulation of cellular amino acid metabolic processGO:004576320.020
regulation of cytoplasmic transportGO:19036491490.020
detection of stimulusGO:0051606850.019
positive regulation of protein transportGO:00512221350.019
sequestering of metal ionGO:0051238240.019
negative regulation of protein modification processGO:00314002000.019
regulation of cell adhesionGO:00301551660.019
actin cytoskeleton organizationGO:00300362070.019
positive regulation of hormone biosynthetic processGO:004688640.019
regulation of hormone levelsGO:00108171250.019
negative regulation of gliogenesisGO:001401430.019
morphogenesis of embryonic epitheliumGO:001633140.019
microtubule based processGO:00070172100.019
regulation of cell projection organizationGO:00313441070.018
negative regulation of cellular amine metabolic processGO:003323930.018
protein oligomerizationGO:00512591730.018
plasma membrane organizationGO:00070091150.018
sensory perceptionGO:00076001030.018
ribonucleotide biosynthetic processGO:0009260810.018
regulation of transporter activityGO:0032409820.018
cardiovascular system developmentGO:00723582620.018
cell projection assemblyGO:00300311260.018
response to light stimulusGO:0009416870.018
regulation of actin filament based processGO:00329701410.018
circulatory system developmentGO:00723592620.018
nitrogen compound transportGO:00717051910.018
organelle assemblyGO:00709251760.018
regulation of chemotaxisGO:0050920740.018
reactive oxygen species metabolic processGO:0072593750.018
circulatory system processGO:00030131130.017
establishment of protein localization to membraneGO:00901501210.017
regulation of behaviorGO:0050795820.017
single organismal cell cell adhesionGO:00163371480.017
cellular protein complex assemblyGO:00436231880.017
regulation of neurogenesisGO:0050767820.017
blood circulationGO:00080151130.017
carbohydrate metabolic processGO:00059752070.017
proteolysis involved in cellular protein catabolic processGO:00516032440.017
regulation of intracellular protein transportGO:00331571230.017
negative regulation of multicellular organismal processGO:00512413170.017
central nervous system developmentGO:00074171230.017
regulation of hormone secretionGO:0046883570.017
protein localization to plasma membraneGO:0072659930.017
oocyte developmentGO:004859910.017
anatomical structure formation involved in morphogenesisGO:00486462840.017
rhythmic behaviorGO:000762220.017
response to organonitrogen compoundGO:00102431560.017
negative regulation of cell cycleGO:00457861930.017
establishment of protein localization to organelleGO:00725941720.017
single organism carbohydrate metabolic processGO:00447231930.016
neuron developmentGO:00486661130.016
organic hydroxy compound metabolic processGO:19016151470.016
immune responseGO:00069553070.016
sodium ion transmembrane transportGO:0035725590.016
head developmentGO:00603221080.016
nuclear transportGO:00511691790.016
cyclic purine nucleotide metabolic processGO:0052652600.016
regulation of calcium ion transportGO:0051924790.016
regulation of acrosome reactionGO:006004640.016
negative regulation of intracellular signal transductionGO:19025321830.016
protein maturationGO:00516042330.016
regulation of actin cytoskeleton organizationGO:00329561160.016
positive regulation of apoptotic processGO:00430652460.016
tripartite regional subdivisionGO:000735120.016
protein processingGO:00164852260.016
response to woundingGO:00096111680.016
hindbrain developmentGO:003090230.016
spermatid differentiationGO:004851540.016
oocyte differentiationGO:000999420.016
camp biosynthetic processGO:0006171470.015
exocytosisGO:0006887710.015
brain developmentGO:0007420970.015
nucleocytoplasmic transportGO:00069131760.015
positive regulation of steroid hormone biosynthetic processGO:009003120.015
regulation of axon extension involved in axon guidanceGO:004884120.015
posttranscriptional regulation of gene expressionGO:00106082130.015
neuron projection regenerationGO:003110210.015
striated muscle contractionGO:0006941520.015
negative regulation of cell proliferationGO:00082852280.015
reactive oxygen species biosynthetic processGO:190340940.015
regulation of nervous system developmentGO:0051960880.015
regulation of peptidase activityGO:00525471800.015
purine nucleotide biosynthetic processGO:0006164840.015
regulation of neuron projection developmentGO:0010975570.015
regulation of cell morphogenesis involved in differentiationGO:0010769830.015
cellular response to organic cyclic compoundGO:00714071270.015
positive regulation of aldosterone biosynthetic processGO:003234920.015
apoptotic signaling pathwayGO:00971902680.015
regulation of epithelial cell proliferationGO:00506781130.015
sequestering of calcium ionGO:0051208170.015
regulation of wnt signaling pathwayGO:00301111230.015
cell divisionGO:00513011680.015
peptidyl tyrosine modificationGO:00182121700.015
regulation of axon guidanceGO:190266730.015
regulation of neuron differentiationGO:0045664700.015
modification dependent macromolecule catabolic processGO:00436322120.015
positive regulation of cell deathGO:00109422630.015
regulation of protein serine threonine kinase activityGO:00719001790.015
epithelium developmentGO:00604292270.014
startle responseGO:000196430.014
regulation of protein catabolic processGO:00421761550.014
positive regulation of cellular component biogenesisGO:00440891580.014
defense responseGO:00069523150.014
regulation of cyclic nucleotide metabolic processGO:0030799630.014
metencephalon developmentGO:002203720.014
limbic system developmentGO:002176130.014
spermatid developmentGO:000728640.014
wnt signaling pathwayGO:00160551560.014
anterior posterior axis specificationGO:000994820.014
embryonic epithelial tube formationGO:000183840.014
positive regulation of programmed cell deathGO:00430682490.014
hormone metabolic processGO:0042445610.014
multicellular organismal response to stressGO:003355510.014
visual learningGO:000854210.014
signal releaseGO:0023061700.014
response to hormoneGO:00097251750.014
visual behaviorGO:000763220.014
regulation of reactive oxygen species metabolic processGO:2000377410.014
positive regulation of cell differentiationGO:00455972110.014
regulation of heart contractionGO:0008016500.014
chemotaxisGO:00069351570.014
regulation of vesicle mediated transportGO:00606271300.014
response to disaccharideGO:003428510.014
regulation of purine nucleotide biosynthetic processGO:1900371500.014
positive regulation of axon extensionGO:004577340.014
regulation of reactive oxygen species biosynthetic processGO:190342630.014
cyclic nucleotide metabolic processGO:0009187820.014
cellular lipid metabolic processGO:00442553030.014
negative regulation of cell differentiationGO:00455961710.014
regulation of cyclic nucleotide biosynthetic processGO:0030802490.013
regulation of cytokine productionGO:00018172320.013
cardiac muscle contractionGO:0060048340.013
negative regulation of growthGO:0045926970.013
synaptic transmission cholinergicGO:000727120.013
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.013
microtubule cytoskeleton organizationGO:00002261760.013
actin filament based movementGO:0030048170.013
matingGO:000761810.013
protein localization to nucleusGO:00345041360.013
stem cell divisionGO:001714520.013
negative regulation of protein maturationGO:19033181420.013
blood vessel morphogenesisGO:00485141620.013
regulation of cellular component sizeGO:0032535820.013
mitotic cell cycle phase transitionGO:00447721620.013
proteasomal protein catabolic processGO:00104981760.013
neuron projection morphogenesisGO:0048812500.013
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.013
regulation of system processGO:00440571010.013
protein importGO:00170381300.013
endocytosisGO:00068971590.013
inner ear morphogenesisGO:004247240.013
regulation of endopeptidase activityGO:00525481700.013
actin mediated cell contractionGO:0070252120.013
heart processGO:0003015620.013
action potentialGO:0001508340.013
protein acylationGO:00435431380.013
heart developmentGO:0007507950.013
heart contractionGO:0060047620.013
compound eye developmentGO:004874910.013
peptidyl tyrosine phosphorylationGO:00181081700.013
negative regulation of phosphorylationGO:00423261740.013
anterior posterior axis specification embryoGO:000859520.013
membrane hyperpolarizationGO:006008110.012
cellular response to hormone stimulusGO:00328701250.012
regulation of protein maturationGO:19033171500.012
calcium ion transmembrane transportGO:0070588760.012
negative regulation of transferase activityGO:00513481240.012
positive regulation of organelle organizationGO:00106381950.012
circadian behaviorGO:004851220.012
ameboidal type cell migrationGO:00016671350.012
modification dependent protein catabolic processGO:00199412090.012
regulation of blood circulationGO:1903522590.012
long term memoryGO:000761620.012
peptidyl serine modificationGO:00182091060.012
regulation of dephosphorylationGO:0035303960.012
ubiquitin dependent protein catabolic processGO:00065112060.012
anion transmembrane transportGO:0098656760.012
regulation of protein complex assemblyGO:00432541470.012
protein targeting to nucleusGO:00447441040.012
cellular response to nitrogen compoundGO:19016991440.012
neural tube closureGO:000184330.012
response to cytokineGO:00340972320.012
chromatin modificationGO:00165682980.012
rna processingGO:00063962550.012
regulation of mitotic cell cycleGO:00073461890.012
meiosis iGO:000712740.012
regulation of nucleocytoplasmic transportGO:0046822980.012
positive regulation of secretion by cellGO:19035321080.012
response to oxidative stressGO:00069791210.012
epithelial cell proliferationGO:00506731280.012
negative regulation of organelle organizationGO:00106391260.012
post embryonic organ developmentGO:004856910.012
regulation of peptidyl tyrosine phosphorylationGO:00507301080.012
cell cycle phase transitionGO:00447701730.012
regulation of anatomical structure sizeGO:00900661010.012
cellular response to organonitrogen compoundGO:00714171240.012
adenylate cyclase inhibiting g protein coupled receptor signaling pathwayGO:0007193220.012
regulation of rho gtpase activityGO:0032319660.012
endosomal transportGO:00161971290.012
epithelial cell migrationGO:00106311190.012
phototransductionGO:000760230.012
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.012
regulation of male gonad developmentGO:200001840.012
positive regulation of intracellular transportGO:00323881040.012
negative regulation of cell growthGO:0030308830.012
cellular response to transforming growth factor beta stimulusGO:0071560940.012
vasculature developmentGO:00019441810.012
cartilage condensationGO:000150210.012
epithelium migrationGO:00901321190.012
regulation of neural precursor cell proliferationGO:200017740.012
sex determinationGO:000753030.012
regulation of multi organism processGO:00439001570.012
response to external biotic stimulusGO:00432072610.012
leukocyte migrationGO:00509001070.012
negative regulation of proteolysisGO:00458611320.011
response to fungusGO:000962040.011
positive regulation of secretionGO:00510471160.011
cell substrate adhesionGO:00315891320.011
regulation of sequence specific dna binding transcription factor activityGO:00510902110.011
muscle structure developmentGO:0061061980.011
syncytium formation by plasma membrane fusionGO:000076820.011
regulation of cysteine type endopeptidase activityGO:20001161270.011
negative regulation of synaptic transmissionGO:005080520.011
positive regulation of acrosome reactionGO:200034440.011
reactive nitrogen species metabolic processGO:200105730.011
regulation of lyase activityGO:0051339230.011
activation of protein kinase activityGO:0032147900.011

EFR3B disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
sensory system diseaseDOID:00501552030.036
nervous system diseaseDOID:8634310.036
musculoskeletal system diseaseDOID:172230.033
central nervous system diseaseDOID:3311860.024
cancerDOID:1621670.023
disease of cellular proliferationDOID:145661740.023
eye and adnexa diseaseDOID:14921500.023
eye diseaseDOID:56141490.023
organ system cancerDOID:00506861640.022
retinal diseaseDOID:56791180.021
disease of metabolismDOID:00146672950.016
muscle tissue diseaseDOID:661130.015
muscular diseaseDOID:00800001140.015
cardiovascular system diseaseDOID:12871060.014
retinal degenerationDOID:8466890.014
disease of mental healthDOID:150700.014
inherited metabolic disorderDOID:6552420.013
myopathyDOID:4231040.013
brain diseaseDOID:936730.012
connective tissue diseaseDOID:651090.012