Homo sapiens

56 known processes

EIF4E

eukaryotic translation initiation factor 4E

(Aliases: EIF4E1,MGC111573,CBP,EIF4F,EIF4EL1)

EIF4E biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
translational initiationGO:0006413480.971
mitotic cell cycle processGO:19030472860.799
posttranscriptional regulation of gene expressionGO:00106082130.712
regulation of translationGO:0006417890.650
positive regulation of cell cycleGO:00457871400.644
determination of adult lifespanGO:000834020.617
Worm
g1 s transition of mitotic cell cycleGO:0000082780.534
response to organonitrogen compoundGO:00102431560.487
regulation of transferase activityGO:00513383550.444
cellular response to nitrogen compoundGO:19016991440.440
protein localization to membraneGO:00726571600.434
regulation of proteolysisGO:00301622930.432
cellular response to hormone stimulusGO:00328701250.413
protein import into mitochondrial matrixGO:003015010.398
mitotic cell cycleGO:00002783260.391
organonitrogen compound biosynthetic processGO:19015662000.388
regulation of cell cycleGO:00517263930.378
cellular amine metabolic processGO:0044106410.370
cellular macromolecule catabolic processGO:00442653800.326
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.304
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.282
neuromuscular junction developmentGO:000752830.281
negative regulation of catalytic activityGO:00430863350.278
multicellular organismal agingGO:001025930.278
Worm
agingGO:0007568660.269
Worm
positive regulation of proteolysisGO:00458621420.255
growthGO:00400072020.253
Fly
mitotic nuclear divisionGO:00070671190.253
Fly
amine metabolic processGO:0009308440.246
microtubule based processGO:00070172100.227
Fly
regulation of cellular component biogenesisGO:00440872810.223
meiotic chromosome segregationGO:004513240.218
Worm Fly
regenerationGO:003109940.216
protein processingGO:00164852260.214
single organism cellular localizationGO:19025803320.213
negative regulation of cellular component organizationGO:00511292350.204
response to peptideGO:1901652650.202
cellular response to dna damage stimulusGO:00069743790.200
negative regulation of transferase activityGO:00513481240.198
negative regulation of protein metabolic processGO:00512483910.197
chromosome segregationGO:00070591140.178
Worm Fly
somitogenesisGO:000175620.172
cell cycle g1 s phase transitionGO:0044843800.171
small molecule biosynthetic processGO:00442831570.170
cellular response to oxygen containing compoundGO:19017012760.167
epithelium developmentGO:00604292270.164
negative regulation of phosphorylationGO:00423261740.158
regulation of kinase activityGO:00435493140.158
positive regulation of hydrolase activityGO:00513453310.157
negative regulation of protein processingGO:00109551420.138
negative regulation of phosphorus metabolic processGO:00105632670.134
modification dependent protein catabolic processGO:00199412090.131
negative regulation of kinase activityGO:00336731060.129
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.126
regulation of mitotic cell cycleGO:00073461890.125
response to nitrogen compoundGO:19016981840.123
female gamete generationGO:000729220.122
Worm
sulfur compound biosynthetic processGO:0044272380.122
positive regulation of peptidase activityGO:0010952880.118
tube developmentGO:00352951250.116
single organism membrane organizationGO:00448022680.115
protein maturationGO:00516042330.114
tor signalingGO:0031929390.114
negative regulation of phosphate metabolic processGO:00459362670.112
regulation of translational initiationGO:0006446240.111
response to hormoneGO:00097251750.111
neuron differentiationGO:00301821380.110
positive regulation of cellular amine metabolic processGO:003324070.106
nuclear divisionGO:00002801280.105
Worm Fly
coenzyme metabolic processGO:0006732650.105
response to peptide hormoneGO:0043434610.099
regulation of cysteine type endopeptidase activityGO:20001161270.099
regulation of cellular ketone metabolic processGO:0010565500.099
sulfur compound metabolic processGO:00067901010.098
negative regulation of cellular protein metabolic processGO:00322693530.095
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.094
mrna metabolic processGO:00160711750.093
mapk cascadeGO:00001652880.091
locomotory behaviorGO:000762610.090
apoptotic signaling pathwayGO:00971902680.090
protein catabolic processGO:00301633250.090
response to amino acidGO:0043200140.089
regulation of cellular amine metabolic processGO:0033238110.088
negative regulation of cell proliferationGO:00082852280.087
neuron developmentGO:00486661130.085
cell morphogenesisGO:00009022960.083
positive regulation of catabolic processGO:00098963100.083
regulation of proteasomal protein catabolic processGO:0061136870.083
regulation of cellular component movementGO:00512703340.082
insulin receptor signaling pathwayGO:0008286230.081
camp mediated signalingGO:0019933230.080
modification dependent macromolecule catabolic processGO:00436322120.079
cell developmentGO:00484683280.079
Worm Fly
positive regulation of organelle organizationGO:00106381950.078
rna splicing via transesterification reactionsGO:0000375900.078
cellular response to peptide hormone stimulusGO:0071375560.077
regulation of response to external stimulusGO:00321012220.074
organophosphate biosynthetic processGO:00904071630.073
stress activated protein kinase signaling cascadeGO:0031098940.072
generation of neuronsGO:00486991520.072
regulation of map kinase activityGO:00434051080.072
regulation of cell migrationGO:00303342890.072
positive regulation of cysteine type endopeptidase activityGO:2001056790.071
regulation of stress activated mapk cascadeGO:0032872840.071
enzyme linked receptor protein signaling pathwayGO:00071673030.070
mrna processingGO:00063971330.070
regulation of protein localizationGO:00328802960.069
proteasomal protein catabolic processGO:00104981760.069
establishment of organelle localizationGO:0051656590.069
lipid metabolic processGO:00066293810.068
regulation of cellular amino acid metabolic processGO:000652160.066
cytoplasmic translational initiationGO:000218360.063
cellular response to organonitrogen compoundGO:00714171240.062
proteolysis involved in cellular protein catabolic processGO:00516032440.062
intrinsic apoptotic signaling pathwayGO:00971931270.062
spermidine metabolic processGO:000821630.061
negative regulation of cell deathGO:00605483450.061
cellular ketone metabolic processGO:0042180800.061
organic anion transportGO:00157111030.060
transmembrane transportGO:00550853990.060
autophagyGO:0006914880.060
secretionGO:00469032540.059
peptidyl serine phosphorylationGO:00181051010.059
signal transduction by phosphorylationGO:00230142970.059
microtubule cytoskeleton organizationGO:00002261760.059
Fly
regulation of protein serine threonine kinase activityGO:00719001790.057
post embryonic developmentGO:000979120.057
Fly
oogenesisGO:004847720.056
Worm
morphogenesis of embryonic epitheliumGO:001633140.056
regulation of endopeptidase activityGO:00525481700.056
mrna splicing via spliceosomeGO:0000398890.056
segmentationGO:003528240.055
regulation of cell motilityGO:20001452990.054
regulation of stress activated protein kinase signaling cascadeGO:0070302850.054
regulation of mapk cascadeGO:00434082620.052
cellular protein catabolic processGO:00442572610.051
regulation of peptidase activityGO:00525471800.051
cellular response to peptideGO:1901653590.050
positive regulation of developmental processGO:00510943140.050
actin cytoskeleton organizationGO:00300362070.049
positive regulation of cell deathGO:00109422630.046
positive regulation of endopeptidase activityGO:0010950840.045
positive regulation of cellular amino acid metabolic processGO:004576430.045
cellular response to endogenous stimulusGO:00714953360.045
interspecies interaction between organismsGO:00444191560.045
positive regulation of phosphorylationGO:00423273940.045
vesicle mediated transportGO:00161923710.044
negative regulation of protein serine threonine kinase activityGO:0071901570.044
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.044
regulation of cellular protein catabolic processGO:1903362960.043
behaviorGO:00076101120.043
actin filament organizationGO:00070151280.043
regulation of cell developmentGO:00602841610.042
maintenance of protein locationGO:0045185570.042
nervous system developmentGO:00073992930.042
Fly
response to woundingGO:00096111680.040
negative regulation of mapk cascadeGO:0043409560.040
plasma membrane organizationGO:00070091150.039
positive regulation of apoptotic processGO:00430652460.039
translationGO:00064121320.039
response to insulinGO:0032868450.039
lipid biosynthetic processGO:00086101770.038
maintenance of locationGO:00512351120.038
Worm
ribonucleotide biosynthetic processGO:0009260810.037
negative regulation of cellular catabolic processGO:0031330830.037
negative regulation of establishment of protein localization to plasma membraneGO:009000590.036
cytoplasmic translationGO:000218180.036
dephosphorylationGO:00163112090.036
negative regulation of protein phosphorylationGO:00019331400.035
cellular protein complex assemblyGO:00436231880.035
signal transduction by p53 class mediatorGO:0072331720.035
cellular amino acid metabolic processGO:00065201160.035
digestive tract developmentGO:0048565750.034
jnk cascadeGO:0007254800.034
spermatid differentiationGO:004851540.034
Worm
negative regulation of protein maturationGO:19033181420.034
purine nucleotide biosynthetic processGO:0006164840.033
rna processingGO:00063962550.033
reproductive processGO:00224141060.033
Worm
organic hydroxy compound metabolic processGO:19016151470.032
mitotic cell cycle phase transitionGO:00447721620.031
peptidyl lysine acetylationGO:00183941010.031
response to oxygen containing compoundGO:19017003690.030
negative regulation of protein modification processGO:00314002000.030
nitrogen compound transportGO:00717051910.030
positive regulation of cell migrationGO:00303351720.030
cell projection organizationGO:00300302520.029
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377890.029
cellular biogenic amine metabolic processGO:0006576340.029
syncytium formation by plasma membrane fusionGO:000076820.029
neuron projection developmentGO:00311751060.029
response to starvationGO:0042594590.028
negative regulation of peptidase activityGO:0010466910.027
protein export from nucleusGO:0006611290.027
signal transduction in response to dna damageGO:0042770570.026
second messenger mediated signalingGO:0019932780.026
ras protein signal transductionGO:0007265730.026
regulation of lipid metabolic processGO:0019216960.026
ubiquitin dependent protein catabolic processGO:00065112060.026
regulation of protein complex assemblyGO:00432541470.026
regulation of cell growthGO:00015581350.025
Fly
regulation of apoptotic signaling pathwayGO:20012331750.025
oocyte differentiationGO:000999420.025
Worm
regulation of cellular response to growth factor stimulusGO:0090287760.025
cellular component morphogenesisGO:00329893140.025
regulation of cellular response to stressGO:00801352440.024
positive regulation of programmed cell deathGO:00430682490.024
response to nutrient levelsGO:0031667810.024
response to alcoholGO:0097305640.024
response to tumor necrosis factorGO:0034612760.024
cell cycle phase transitionGO:00447701730.024
somatic muscle developmentGO:000752510.024
negative regulation of protein complex assemblyGO:0031333430.024
muscle contractionGO:0006936730.024
regulation of nuclear divisionGO:0051783650.023
negative regulation of hydrolase activityGO:00513461820.023
regulation of rna splicingGO:0043484620.023
regulation of locomotionGO:00400123290.023
small gtpase mediated signal transductionGO:0007264780.023
secretion by cellGO:00329402260.023
positive regulation of cellular catabolic processGO:00313312840.023
protein polyubiquitinationGO:00002091100.022
negative regulation of multi organism processGO:0043901920.022
regulation of chromosome organizationGO:00330441030.022
cellular response to nutrient levelsGO:0031669690.022
neurogenesisGO:00220081690.022
Fly
positive regulation of cell cycle processGO:00900681060.022
regulation of cytoskeleton organizationGO:00514931770.022
activation of cysteine type endopeptidase activityGO:0097202570.022
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625420.021
positive regulation of mitotic cell cycleGO:0045931600.021
negative regulation of lipid metabolic processGO:0045833380.021
negative regulation of cellular amine metabolic processGO:003323930.021
peripheral nervous system developmentGO:000742220.021
protein localization to plasma membraneGO:0072659930.021
myoblast fusionGO:000752010.021
response to axon injuryGO:004867810.021
regulation of neuron projection developmentGO:0010975570.021
regulation of establishment of protein localizationGO:00702012420.021
cell growthGO:00160491600.021
Fly
regulation of purine nucleotide biosynthetic processGO:1900371500.020
nucleic acid phosphodiester bond hydrolysisGO:00903051020.020
regulation of protein catabolic processGO:00421761550.020
regulation of secretion by cellGO:19035301770.020
methionine metabolic processGO:000655550.020
positive regulation of cell motilityGO:20001471770.020
synaptic transmission cholinergicGO:000727120.020
coenzyme biosynthetic processGO:0009108240.019
actin filament based processGO:00300292240.019
organelle localizationGO:0051640840.019
regulation of homeostatic processGO:00328441210.019
negative regulation of stress activated protein kinase signaling cascadeGO:0070303190.019
developmental process involved in reproductionGO:0003006660.018
Worm
regulation of growthGO:00400081650.018
Fly
regulation of transcription by chromatin organizationGO:003440110.018
protein acylationGO:00435431380.018
response to biotic stimulusGO:00096072760.018
biological adhesionGO:00226103310.018
negative regulation of map kinase activityGO:0043407270.018
regulation of excitatory postsynaptic membrane potentialGO:006007910.018
organic acid biosynthetic processGO:0016053970.018
developmental growthGO:0048589480.018
regulation of cell projection organizationGO:00313441070.018
lipid localizationGO:00108761060.017
Worm
positive regulation of transferase activityGO:00513472270.017
cellular response to cytokine stimulusGO:00713451810.017
cellular carbohydrate metabolic processGO:0044262840.017
protein modification by small protein conjugationGO:00324463420.017
extrinsic apoptotic signaling pathwayGO:00971911190.017
ion transmembrane transportGO:00342203380.017
anatomical structure formation involved in morphogenesisGO:00486462840.017
sister chromatid segregationGO:0000819540.017
Fly
morphogenesis of an epitheliumGO:0002009600.017
organ morphogenesisGO:00098871470.017
Fly
associative learningGO:000830610.017
positive regulation of tor signalingGO:0032008110.017
cell morphogenesis involved in differentiationGO:00009041440.016
protein polymerizationGO:0051258710.016
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.016
stress activated mapk cascadeGO:0051403930.016
multicellular organismal reproductive processGO:0048609400.016
Worm
internal peptidyl lysine acetylationGO:0018393970.016
metaphase anaphase transition of cell cycleGO:0044784210.016
protein alkylationGO:0008213740.016
nucleotide biosynthetic processGO:00091651090.016
purine containing compound biosynthetic processGO:0072522880.016
positive regulation of locomotionGO:00400171860.016
nucleoside triphosphate metabolic processGO:00091414220.016
nucleoside phosphate biosynthetic processGO:19012931090.016
cell projection morphogenesisGO:00488581290.016
positive regulation of dna metabolic processGO:0051054730.015
negative regulation of apoptotic processGO:00430663160.015
regulation of nervous system developmentGO:0051960880.015
peptidyl serine modificationGO:00182091060.015
hexose metabolic processGO:0019318550.015
regulation of neuron differentiationGO:0045664700.015
response to external biotic stimulusGO:00432072610.015
regulation of protein kinase activityGO:00458592890.015
regulation of transmembrane transportGO:00347621390.015
single organism carbohydrate metabolic processGO:00447231930.015
regulation of ion transmembrane transporter activityGO:0032412720.015
microtubule organizing center organizationGO:0031023620.015
response to drugGO:0042493810.014
response to virusGO:00096151260.014
spindle organizationGO:0007051530.014
Fly
regulation of response to woundingGO:19030341010.014
centrosome organizationGO:0051297580.014
ribonucleoprotein complex biogenesisGO:00226131160.014
positive regulation of ligase activityGO:0051351190.014
wound healingGO:00420601150.014
embryo developmentGO:00097901230.014
Worm Fly
nls bearing protein import into nucleusGO:000660720.014
cell divisionGO:00513011680.014
regulation of jnk cascadeGO:0046328730.014
maintenance of protein location in cellGO:0032507560.014
negative regulation of transportGO:00510511760.014
lipid storageGO:0019915280.014
Worm
nucleotide catabolic processGO:00091664080.014
cell morphogenesis involved in neuron differentiationGO:0048667440.014
ribosome biogenesisGO:0042254480.013
regulation of protein maturationGO:19033171500.013
microtubule anchoringGO:0034453240.013
cell adhesionGO:00071553250.013
cation transmembrane transportGO:00986552380.013
nucleoside catabolic processGO:00091644080.013
regionalizationGO:0003002290.013
oocyte developmentGO:004859910.013
Worm
response to ketoneGO:1901654190.013
inorganic ion transmembrane transportGO:00986602310.013
glycosyl compound catabolic processGO:19016584130.013
organelle assemblyGO:00709251760.013
nucleoside triphosphate catabolic processGO:00091433940.013
regulation of cell cycle processGO:00105642660.013
protein targetingGO:00066051870.013
canonical wnt signaling pathwayGO:00600701160.012
cytokine productionGO:00018162470.012
protein methylationGO:0006479740.012
negative regulation of multicellular organismal processGO:00512413170.012
actin filament bundle organizationGO:0061572540.012
negative regulation of proteolysisGO:00458611320.012
response to ethanolGO:0045471110.012
establishment of protein localization to membraneGO:00901501210.012
cell part morphogenesisGO:00329901370.012
carboxylic acid biosynthetic processGO:0046394970.012
positive regulation of developmental growthGO:0048639160.012
cellular response to insulin stimulusGO:0032869410.012
regulation of cell morphogenesisGO:00226041530.012
negative regulation of catabolic processGO:00098951040.012
nuclear exportGO:0051168690.012
postsynaptic membrane organizationGO:000194120.012
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.012
spindle assemblyGO:0051225290.012
regulation of lipid kinase activityGO:0043550190.012
regulation of autophagyGO:0010506520.012
mesenchymal cell developmentGO:0014031500.012
anion transportGO:00068201610.012
regulation of cellular component sizeGO:0032535820.012
negative regulation of response to external stimulusGO:0032102830.012
regulation of ion transmembrane transportGO:00347651320.011
positive regulation of cell developmentGO:0010720920.011
defense response to other organismGO:00985421290.011
methylationGO:00322591060.011
regulation of cell divisionGO:00513021160.011
dna catabolic processGO:0006308490.011
establishment of chromosome localizationGO:0051303200.011
cell cell signalingGO:00072671550.011
mesoderm developmentGO:0007498140.011
response to interleukin 1GO:0070555470.011
regulation of ligase activityGO:0051340290.011
pattern specification processGO:0007389430.011
establishment of epithelial cell polarityGO:009016220.011
wnt signaling pathwayGO:00160551560.011
cytoplasmic transportGO:00164823790.011
single fertilizationGO:0007338110.011
negative regulation of jnk cascadeGO:0046329160.011
sulfur amino acid metabolic processGO:0000096140.011
amine biosynthetic processGO:000930940.011
purine ribonucleoside triphosphate metabolic processGO:00092054110.011
negative regulation of intracellular signal transductionGO:19025321830.011
response to oxidative stressGO:00069791210.011
carbohydrate biosynthetic processGO:0016051420.011
negative regulation of programmed cell deathGO:00430693210.011
epithelial cell proliferationGO:00506731280.011
intracellular protein transportGO:00068862700.011
single organism cell adhesionGO:00986021790.011
signal releaseGO:0023061700.011
cognitionGO:0050890430.011
oxidation reduction processGO:00551143960.010
regulation of mrna metabolic processGO:1903311530.010
neural tube formationGO:000184130.010
regulation of metaphase anaphase transition of cell cycleGO:1902099260.010
positive regulation of chromosome organizationGO:2001252410.010
regulation of sister chromatid segregationGO:0033045270.010
positive regulation of cell sizeGO:004579330.010
reproductionGO:0000003630.010
Worm Fly
response to inorganic substanceGO:00100351270.010
response to organic cyclic compoundGO:00140702040.010
dendrite developmentGO:0016358240.010
purine containing compound catabolic processGO:00725234110.010
regulation of protein processingGO:00706131500.010
negative regulation of endopeptidase activityGO:0010951840.010

EIF4E disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.066
inherited metabolic disorderDOID:6552420.055
carbohydrate metabolic disorderDOID:2978550.013
congenital disorder of glycosylation type iDOID:0050570160.013
congenital disorder of glycosylationDOID:5212260.013
central nervous system diseaseDOID:3311860.010
nervous system diseaseDOID:8634310.010
disease of mental healthDOID:150700.002
developmental disorder of mental healthDOID:0060037290.002
autistic disorderDOID:1284990.001
pervasive developmental disorderDOID:0060040100.001
autism spectrum disorderDOID:006004190.001