Homo sapiens

66 known processes

PROL1

proline rich, lacrimal 1

(Aliases: PRL1,BPLP)

PROL1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cation transportGO:00068123310.402
g protein coupled receptor signaling pathwayGO:00071862070.400
ion transmembrane transportGO:00342203380.328
cellular amine metabolic processGO:0044106410.299
transmembrane transportGO:00550853990.298
regulation of ion transportGO:00432691890.280
cellular amino acid metabolic processGO:00065201160.270
regulation of cellular amine metabolic processGO:0033238110.216
metal ion transportGO:00300012720.213
cellular ketone metabolic processGO:0042180800.205
amine metabolic processGO:0009308440.203
positive regulation of cellular amine metabolic processGO:003324070.199
positive regulation of transportGO:00510503360.194
system processGO:00030083490.192
cellular response to endogenous stimulusGO:00714953360.187
regulation of cellular ketone metabolic processGO:0010565500.184
regulation of cellular amino acid metabolic processGO:000652160.176
inorganic ion transmembrane transportGO:00986602310.159
positive regulation of protein phosphorylationGO:00019343130.157
anion transportGO:00068201610.149
response to oxygen containing compoundGO:19017003690.144
regulation of secretionGO:00510461940.139
chemical homeostasisGO:00488783060.137
cation homeostasisGO:00550801890.131
inorganic cation transmembrane transportGO:00986621940.128
secretionGO:00469032540.126
cation transmembrane transportGO:00986552380.125
response to nitrogen compoundGO:19016981840.125
positive regulation of cellular amino acid metabolic processGO:004576430.123
regulation of cellular component movementGO:00512703340.123
metal ion homeostasisGO:00550651690.123
muscle system processGO:0003012810.122
response to organic cyclic compoundGO:00140702040.112
ion homeostasisGO:00508012300.110
positive regulation of cytosolic calcium ion concentrationGO:0007204820.108
cellular homeostasisGO:00197251960.104
cellular ion homeostasisGO:00068731680.100
muscle contractionGO:0006936730.097
cellular chemical homeostasisGO:00550821800.096
regulation of cell migrationGO:00303342890.095
cellular cation homeostasisGO:00300031630.092
regulation of secretion by cellGO:19035301770.091
cellular divalent inorganic cation homeostasisGO:00725031280.091
response to abiotic stimulusGO:00096283360.089
positive regulation of phosphorylationGO:00423273940.088
regulation of ion transmembrane transportGO:00347651320.087
positive regulation of cell proliferationGO:00082843010.084
neurological system processGO:00508771630.082
response to organonitrogen compoundGO:00102431560.080
cellular response to nitrogen compoundGO:19016991440.080
negative regulation of transmission of nerve impulseGO:005197010.078
positive regulation of ion transportGO:0043270870.078
cell cell signalingGO:00072671550.074
cellular response to histamineGO:007142030.072
regulation of kinase activityGO:00435493140.071
gamma aminobutyric acid signaling pathwayGO:000721430.071
cytosolic calcium ion homeostasisGO:0051480890.071
negative regulation of cell deathGO:00605483450.070
regulation of metal ion transportGO:00109591200.070
defense responseGO:00069523150.067
regulation of system processGO:00440571010.067
multicellular organismal signalingGO:0035637340.067
regulation of transmission of nerve impulseGO:005196920.067
divalent inorganic cation homeostasisGO:00725071360.066
regulation of cell motilityGO:20001452990.065
cellular metal ion homeostasisGO:00068751460.065
regulation of locomotionGO:00400123290.065
mapk cascadeGO:00001652880.064
calcium ion homeostasisGO:00550741220.064
positive regulation of protein kinase activityGO:00458601900.064
regulation of protein kinase activityGO:00458592890.060
response to biotic stimulusGO:00096072760.060
cytoplasmic transportGO:00164823790.058
negative regulation of multicellular organismal processGO:00512413170.058
vesicle mediated transportGO:00161923710.057
secretion by cellGO:00329402260.057
regulation of hormone levelsGO:00108171250.057
calcium ion transportGO:00068161470.057
regulation of transferase activityGO:00513383550.056
response to other organismGO:00517072610.055
positive regulation of cellular component movementGO:00512721810.055
cellular calcium ion homeostasisGO:00068741170.053
positive regulation of developmental processGO:00510943140.052
regulation of mapk cascadeGO:00434082620.052
negative regulation of transportGO:00510511760.050
response to hormoneGO:00097251750.050
cellular response to organic cyclic compoundGO:00714071270.050
divalent inorganic cation transportGO:00725111580.050
post embryonic developmentGO:000979120.049
regulation of membrane potentialGO:0042391950.049
nitrogen compound transportGO:00717051910.048
peptidyl tyrosine phosphorylationGO:00181081700.048
actin filament based processGO:00300292240.048
divalent metal ion transportGO:00708381520.047
organonitrogen compound biosynthetic processGO:19015662000.047
behaviorGO:00076101120.046
signal transduction by phosphorylationGO:00230142970.046
positive regulation of kinase activityGO:00336742040.046
response to external biotic stimulusGO:00432072610.045
peptidyl tyrosine modificationGO:00182121700.045
immune responseGO:00069553070.045
regulation of purine nucleotide metabolic processGO:19005422640.044
regulation of acrosome reactionGO:006004640.044
regulation of proteolysisGO:00301622930.044
monovalent inorganic cation transportGO:00156721280.044
response to cytokineGO:00340972320.043
positive regulation of cellular component organizationGO:00511303760.042
single organism cellular localizationGO:19025803320.041
regulation of cell differentiationGO:00455953930.041
regulation of transmembrane transportGO:00347621390.041
lipid metabolic processGO:00066293810.041
response to lipidGO:00339932060.040
regulation of protein transportGO:00512232130.040
tissue migrationGO:00901301190.040
positive regulation of hydrolase activityGO:00513453310.040
regulation of intracellular transportGO:00323861950.040
locomotory behaviorGO:000762610.039
nervous system developmentGO:00073992930.039
cellular response to oxygen containing compoundGO:19017012760.039
negative regulation of protein metabolic processGO:00512483910.039
circulatory system processGO:00030131130.039
positive regulation of purine nucleotide metabolic processGO:19005442270.039
cellular response to organonitrogen compoundGO:00714171240.039
blood circulationGO:00080151130.039
regulation of cell cycleGO:00517263930.038
regulation of calcium ion transportGO:0051924790.038
cell activationGO:00017752130.038
negative regulation of cellular protein metabolic processGO:00322693530.038
regulation of cell cycle processGO:00105642660.038
regulation of nucleotide metabolic processGO:00061402690.037
female gamete generationGO:000729220.037
negative regulation of apoptotic processGO:00430663160.037
positive regulation of transferase activityGO:00513472270.037
purine ribonucleotide catabolic processGO:00091544040.037
small gtpase mediated signal transductionGO:0007264780.037
positive regulation of cell migrationGO:00303351720.036
positive regulation of cell motilityGO:20001471770.036
response to woundingGO:00096111680.036
regulation of establishment of protein localizationGO:00702012420.036
carbohydrate derivative biosynthetic processGO:19011372070.035
organophosphate biosynthetic processGO:00904071630.035
regulation of cytokine productionGO:00018172320.035
positive regulation of acrosome reactionGO:200034440.034
cell adhesionGO:00071553250.034
biological adhesionGO:00226103310.034
cellular response to hormone stimulusGO:00328701250.034
nucleotide catabolic processGO:00091664080.033
nucleoside phosphate catabolic processGO:19012924120.033
cyclic nucleotide metabolic processGO:0009187820.033
sensory perceptionGO:00076001030.032
cardiovascular system developmentGO:00723582620.032
positive regulation of immune system processGO:00026842830.032
negative regulation of programmed cell deathGO:00430693210.031
negative regulation of cell proliferationGO:00082852280.031
purine ribonucleoside triphosphate catabolic processGO:00092073910.031
memoryGO:000761330.031
cytokine productionGO:00018162470.031
negative regulation of catalytic activityGO:00430863350.031
nucleoside triphosphate metabolic processGO:00091414220.031
circulatory system developmentGO:00723592620.031
positive regulation of programmed cell deathGO:00430682490.030
chemotaxisGO:00069351570.030
regulation of protein serine threonine kinase activityGO:00719001790.030
startle responseGO:000196430.030
positive regulation of cell cycleGO:00457871400.030
regulation of transmembrane transporter activityGO:0022898740.030
regenerationGO:003109940.030
negative regulation of phosphorus metabolic processGO:00105632670.030
cellular response to growth factor stimulusGO:00713631970.030
neuromuscular junction developmentGO:000752830.030
multicellular organismal agingGO:001025930.029
response to growth factorGO:00708482050.029
positive regulation of cell differentiationGO:00455972110.029
ribonucleotide catabolic processGO:00092614050.029
cellular lipid metabolic processGO:00442553030.029
apoptotic signaling pathwayGO:00971902680.029
regulation of cellular component biogenesisGO:00440872810.029
regulation of anatomical structure morphogenesisGO:00226032860.029
protein maturationGO:00516042330.028
purine ribonucleotide biosynthetic processGO:0009152790.028
maintenance of locationGO:00512351120.028
inorganic anion transmembrane transportGO:0098661470.028
positive regulation of secretionGO:00510471160.028
cell divisionGO:00513011680.028
leukocyte activationGO:00453211640.028
purine containing compound catabolic processGO:00725234110.028
ribonucleoside triphosphate catabolic processGO:00092033910.028
epithelial cell proliferationGO:00506731280.027
anion transmembrane transportGO:0098656760.027
positive regulation of locomotionGO:00400171860.027
protein localization to organelleGO:00333652800.027
nucleoside catabolic processGO:00091644080.027
mitotic cell cycleGO:00002783260.026
chloride transportGO:0006821410.026
innate immune responseGO:00450871780.026
positive regulation of cell deathGO:00109422630.026
neuropeptide signaling pathwayGO:0007218190.026
purine ribonucleoside triphosphate metabolic processGO:00092054110.026
ras protein signal transductionGO:0007265730.026
purine nucleoside triphosphate catabolic processGO:00091463920.026
regulation of peptidyl tyrosine phosphorylationGO:00507301080.026
sensory perception of chemical stimulusGO:0007606380.026
intracellular protein transportGO:00068862700.026
purine ribonucleoside metabolic processGO:00461284370.026
negative regulation of locomotionGO:00400131180.026
regulation of growthGO:00400081650.025
positive regulation of nucleotide metabolic processGO:00459812300.025
ribonucleoside catabolic processGO:00424544060.025
positive regulation of mapk cascadeGO:00434101900.025
negative regulation of phosphate metabolic processGO:00459362670.025
potassium ion transportGO:0006813620.025
regulation of homeostatic processGO:00328441210.025
interspecies interaction between organismsGO:00444191560.025
purine nucleoside catabolic processGO:00061523980.025
purine nucleotide catabolic processGO:00061954050.025
negative regulation of developmental processGO:00510932470.025
striated muscle contractionGO:0006941520.025
regulation of response to external stimulusGO:00321012220.025
regulation of protein localizationGO:00328802960.025
positive regulation of protein serine threonine kinase activityGO:00719021190.024
regulation of actin filament based processGO:00329701410.024
organophosphate catabolic processGO:00464344300.024
cell developmentGO:00484683280.024
mitotic cell cycle processGO:19030472860.024
positive regulation of cytokine productionGO:00018191670.024
oogenesisGO:004847720.024
cellular response to cytokine stimulusGO:00713451810.024
growthGO:00400072020.024
regulation of nucleotide catabolic processGO:00308112050.024
regulation of ion transmembrane transporter activityGO:0032412720.024
immune system developmentGO:00025201950.024
angiogenesisGO:00015251470.024
small molecule biosynthetic processGO:00442831570.024
membrane organizationGO:00610242920.024
lipid biosynthetic processGO:00086101770.023
single organism membrane organizationGO:00448022680.023
synaptic transmissionGO:0007268610.023
purine nucleoside triphosphate metabolic processGO:00091444120.023
ribonucleotide biosynthetic processGO:0009260810.023
negative regulation of cellular component movementGO:00512711060.023
regulation of gtpase activityGO:00430871800.023
regulation of hormone secretionGO:0046883570.023
regulation of response to woundingGO:19030341010.023
associative learningGO:000830610.023
regulation of cytoplasmic transportGO:19036491490.023
positive regulation of nucleotide catabolic processGO:00308131850.023
regulation of multi organism processGO:00439001570.023
sequestering of calcium ionGO:0051208170.023
anatomical structure formation involved in morphogenesisGO:00486462840.023
determination of adult lifespanGO:000834020.022
hormone transportGO:0009914680.022
detection of chemical stimulus involved in sensory perceptionGO:0050907330.022
response to drugGO:0042493810.022
detection of stimulusGO:0051606850.022
negative regulation of cellular component organizationGO:00511292350.022
enzyme linked receptor protein signaling pathwayGO:00071673030.022
cellular macromolecule catabolic processGO:00442653800.022
activation of protein kinase activityGO:0032147900.022
camp metabolic processGO:0046058610.022
glycosyl compound catabolic processGO:19016584130.022
positive regulation of cellular catabolic processGO:00313312840.022
epithelium migrationGO:00901321190.022
cell growthGO:00160491600.021
wound healingGO:00420601150.021
cell morphogenesisGO:00009022960.021
epithelial cell differentiationGO:00308551410.021
cellular component morphogenesisGO:00329893140.021
leukocyte migrationGO:00509001070.021
nucleoside triphosphate catabolic processGO:00091433940.021
cardiac muscle cell contractionGO:008600340.021
positive regulation of apoptotic processGO:00430652460.021
adenylate cyclase inhibiting serotonin receptor signaling pathwayGO:000719820.021
regulation of cell adhesionGO:00301551660.021
protein oligomerizationGO:00512591730.021
epithelium developmentGO:00604292270.021
regulation of transporter activityGO:0032409820.021
negative regulation of synaptic transmissionGO:005080520.021
multi organism cellular processGO:00447641560.021
reproductive processGO:00224141060.021
nucleotide biosynthetic processGO:00091651090.021
positive regulation of protein transportGO:00512221350.020
cellular macromolecular complex assemblyGO:00346223240.020
response to inorganic substanceGO:00100351270.020
actin mediated cell contractionGO:0070252120.020
negative regulation of cell motilityGO:20001461040.020
taxisGO:00423301570.020
symbiosis encompassing mutualism through parasitismGO:00444031560.020
sequestering of metal ionGO:0051238240.020
nucleoside phosphate biosynthetic processGO:19012931090.020
central nervous system developmentGO:00074171230.020
regulation of apoptotic signaling pathwayGO:20012331750.020
cellular response to ammonium ionGO:007124240.020
neuroblast proliferationGO:000740540.020
protein catabolic processGO:00301633250.019
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathwayGO:003562540.019
regulation of cell activationGO:00508651250.019
cell projection organizationGO:00300302520.019
regulation of purine nucleotide catabolic processGO:00331212050.019
ribonucleoside triphosphate metabolic processGO:00091994120.019
purine ribonucleoside catabolic processGO:00461303980.019
positive regulation of secretion by cellGO:19035321080.019
ribose phosphate biosynthetic processGO:0046390820.019
transmission of nerve impulseGO:0019226110.019
multicellular organismal homeostasisGO:0048871670.019
cellular potassium ion transportGO:0071804600.019
neurogenesisGO:00220081690.019
regulation of vesicle mediated transportGO:00606271300.019
positive regulation of catabolic processGO:00098963100.019
glycerolipid metabolic processGO:00464861070.019
generation of neuronsGO:00486991520.018
response to decreased oxygen levelsGO:0036293960.018
negative regulation of immune system processGO:00026831360.018
single organism carbohydrate metabolic processGO:00447231930.018
regulation of epithelial cell proliferationGO:00506781130.018
brain developmentGO:0007420970.018
positive regulation of response to external stimulusGO:0032103880.018
hemopoiesisGO:00300971800.018
regulation of cell divisionGO:00513021160.018
negative regulation of intracellular signal transductionGO:19025321830.018
positive regulation of nucleoside metabolic processGO:00459791860.018
negative regulation of secretionGO:0051048580.018
sensory perception of painGO:001923340.018
oocyte differentiationGO:000999420.018
blood vessel developmentGO:00015681720.018
sodium ion transportGO:0006814610.018
negative regulation of protein processingGO:00109551420.018
cellular response to dna damage stimulusGO:00069743790.018
positive regulation of intracellular transportGO:00323881040.018
action potentialGO:0001508340.018
regulation of cell growthGO:00015581350.018
positive regulation of cellular component biogenesisGO:00440891580.018
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.018
inorganic anion transportGO:0015698600.018
limbic system developmentGO:002176130.018
oocyte developmentGO:004859910.018
hormone secretionGO:0046879650.018
morphogenesis of embryonic epitheliumGO:001633140.018
regulation of ion homeostasisGO:2000021730.017
actin filament based movementGO:0030048170.017
immune effector processGO:00022521590.017
regulation of protein catabolic processGO:00421761550.017
regulation of protein processingGO:00706131500.017
negative regulation of protein maturationGO:19033181420.017
response to metal ionGO:0010038840.017
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.017
regulation of bindingGO:00510981110.017
guanosine containing compound metabolic processGO:19010682440.017
cytokine mediated signaling pathwayGO:00192211090.017
regulation of cyclic nucleotide metabolic processGO:0030799630.017
regulation of nucleoside metabolic processGO:00091182090.017
leukocyte chemotaxisGO:0030595760.017
negative regulation of cell cycleGO:00457861930.017
regulation of erk1 and erk2 cascadeGO:0070372990.017
positive regulation of epithelial cell proliferationGO:0050679650.017
blood vessel morphogenesisGO:00485141620.017
regulation of cellular response to stressGO:00801352440.017
nuclear transportGO:00511691790.016
amide transportGO:0042886760.016
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187430.016
viral processGO:00160321460.016
organ morphogenesisGO:00098871470.016
regulation of body fluid levelsGO:0050878990.016
cyclic purine nucleotide metabolic processGO:0052652600.016
purine containing compound biosynthetic processGO:0072522880.016
response to bacteriumGO:00096171440.016
vasculature developmentGO:00019441810.016
cellular response to lipidGO:00713961270.016
positive regulation of cytoplasmic transportGO:1903651820.016
positive regulation of map kinase activityGO:0043406800.016
regulation of behaviorGO:0050795820.016
hormone metabolic processGO:0042445610.016
endothelial cell proliferationGO:0001935650.016
protein processingGO:00164852260.016
response to light stimulusGO:0009416870.016
actin cytoskeleton organizationGO:00300362070.016
response to axon injuryGO:004867810.016
organic anion transportGO:00157111030.016
segmentationGO:003528240.016
viral life cycleGO:00190581320.016
hindbrain developmentGO:003090230.016
response to hypoxiaGO:0001666960.016
negative regulation of hydrolase activityGO:00513461820.016
peripheral nervous system developmentGO:000742220.016
dephosphorylationGO:00163112090.016
regulation of leukocyte activationGO:00026941150.016
ameboidal type cell migrationGO:00016671350.015
cell cycle phase transitionGO:00447701730.015
positive regulation of proteolysisGO:00458621420.015
response to oxygen levelsGO:00704821000.015
inflammatory responseGO:0006954790.015
positive regulation of cell cycle processGO:00900681060.015
chloride transmembrane transportGO:1902476380.015
regulation of endopeptidase activityGO:00525481700.015
regulation of cytoskeleton organizationGO:00514931770.015
lipid transportGO:0006869900.015
establishment of protein localization to organelleGO:00725941720.015
nucleocytoplasmic transportGO:00069131760.015
endocytosisGO:00068971590.015
spermatid differentiationGO:004851540.015
regulation of map kinase activityGO:00434051080.015
organic hydroxy compound metabolic processGO:19016151470.015
epithelial cell migrationGO:00106311190.015
chromatin organizationGO:00063253510.015
regulation of sequence specific dna binding transcription factor activityGO:00510902110.015
negative regulation of protein modification processGO:00314002000.015
positive regulation of organelle organizationGO:00106381950.015
carbohydrate metabolic processGO:00059752070.015
negative regulation of multi organism processGO:0043901920.015
gtp catabolic processGO:00061842370.015
protein importGO:00170381300.015
endomembrane system organizationGO:00102561960.015
negative regulation of cellular amino acid metabolic processGO:004576320.015
single organism reproductive processGO:0044702980.015
regulation of immune responseGO:00507762010.015
phospholipid metabolic processGO:0006644990.015
positive regulation of purine nucleotide catabolic processGO:00331231850.015
protein targetingGO:00066051870.015
regulation of i kappab kinase nf kappab signalingGO:00431221620.015
negative regulation of secretion by cellGO:1903531520.014
protein localization to membraneGO:00726571600.014
proteolysis involved in cellular protein catabolic processGO:00516032440.014
positive regulation of cyclic nucleotide biosynthetic processGO:0030804380.014
negative regulation of phosphorylationGO:00423261740.014
activation of mapk activityGO:0000187450.014
negative regulation of homeostatic processGO:0032845590.014
cardiac muscle contractionGO:0060048340.014
posttranscriptional regulation of gene expressionGO:00106082130.014
glycerophospholipid metabolic processGO:0006650840.014
single organismal cell cell adhesionGO:00163371480.014
rho protein signal transductionGO:0007266260.014
ossificationGO:00015031210.014
regulation of protein bindingGO:0043393660.014
cell substrate adhesionGO:00315891320.014
cell chemotaxisGO:00603261120.014
regulation of cysteine type endopeptidase activityGO:20001161270.014
purine nucleotide biosynthetic processGO:0006164840.014
regulation of cyclic nucleotide biosynthetic processGO:0030802490.014
head developmentGO:00603221080.014
regulation of small gtpase mediated signal transductionGO:00510561560.014
guanosine containing compound catabolic processGO:19010692390.014
plasma membrane organizationGO:00070091150.014
cellular protein complex assemblyGO:00436231880.014
negative regulation of cell migrationGO:00303361020.014
protein localization to nucleusGO:00345041360.014
regulation of angiogenesisGO:0045765920.014
response to radiationGO:00093141510.014
visual behaviorGO:000763220.014
gtp metabolic processGO:00460392390.014
spermatid developmentGO:000728640.013
response to fungusGO:000962040.013
regulation of mitotic cell cycleGO:00073461890.013
sensory perception of tasteGO:0050909360.013
purine ribonucleoside monophosphate metabolic processGO:00091671860.013
regulation of sequestering of calcium ionGO:0051282410.013
multicellular organismal response to stressGO:003355510.013
negative regulation of bindingGO:0051100570.013
cyclic nucleotide biosynthetic processGO:0009190610.013
rhythmic behaviorGO:000762220.013
mitotic cell cycle phase transitionGO:00447721620.013
tissue morphogenesisGO:0048729960.013
hematopoietic or lymphoid organ developmentGO:00485341860.013
cellular protein catabolic processGO:00442572610.013
negative regulation of proteolysisGO:00458611320.013
reactive nitrogen species metabolic processGO:200105730.013
detection of chemical stimulusGO:0009593550.013
regulation of gtp catabolic processGO:00331241800.013
negative regulation of blood pressureGO:004577630.013
i kappab kinase nf kappab signalingGO:00072491660.013
anatomical structure homeostasisGO:00602491000.013
organic hydroxy compound transportGO:0015850630.013
response to virusGO:00096151260.013
negative regulation of growthGO:0045926970.013
regulation of leukocyte migrationGO:0002685630.013
regulation of blood circulationGO:1903522590.013
positive regulation of cell developmentGO:0010720920.013
protein homooligomerizationGO:00512601000.013
regulation of intracellular protein transportGO:00331571230.012
negative regulation of cellular amine metabolic processGO:003323930.012
monocarboxylic acid metabolic processGO:00327871850.012

PROL1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.053
inherited metabolic disorderDOID:6552420.032
nervous system diseaseDOID:8634310.030
central nervous system diseaseDOID:3311860.030
musculoskeletal system diseaseDOID:172230.023
immune system diseaseDOID:29141550.023
sensory system diseaseDOID:00501552030.018
cancerDOID:1621670.018
disease of cellular proliferationDOID:145661740.018
organ system cancerDOID:00506861640.018
eye and adnexa diseaseDOID:14921500.016
eye diseaseDOID:56141490.016
retinal diseaseDOID:56791180.015
neurodegenerative diseaseDOID:12891020.015
urinary system diseaseDOID:18400.014