Homo sapiens

132 known processes

PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

(Aliases: DEPDC2,DEP.2,6230420N16Rik,P-REX2)

PREX2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
amine metabolic processGO:0009308440.089
cellular amino acid metabolic processGO:00065201160.081
positive regulation of cellular amino acid metabolic processGO:004576430.080
regulation of cellular amino acid metabolic processGO:000652160.074
positive regulation of cellular amine metabolic processGO:003324070.073
cellular amine metabolic processGO:0044106410.064
regulation of cellular amine metabolic processGO:0033238110.063
system processGO:00030083490.062
cellular ketone metabolic processGO:0042180800.062
post embryonic developmentGO:000979120.062
cation transportGO:00068123310.058
ion transmembrane transportGO:00342203380.057
positive regulation of cellular component organizationGO:00511303760.056
metal ion transportGO:00300012720.055
positive regulation of phosphorylationGO:00423273940.054
regulation of cellular ketone metabolic processGO:0010565500.051
inorganic ion transmembrane transportGO:00986602310.050
nucleoside phosphate catabolic processGO:19012924120.050
locomotory behaviorGO:000762610.049
Mouse
inorganic cation transmembrane transportGO:00986621940.049
purine ribonucleotide catabolic processGO:00091544040.048
small gtpase mediated signal transductionGO:0007264780.047
purine ribonucleoside metabolic processGO:00461284370.046
ribonucleoside catabolic processGO:00424544060.046
ras protein signal transductionGO:0007265730.045
purine containing compound catabolic processGO:00725234110.045
cellular ion homeostasisGO:00068731680.044
purine nucleoside triphosphate catabolic processGO:00091463920.044
transmembrane transportGO:00550853990.044
regulation of anatomical structure morphogenesisGO:00226032860.043
chemical homeostasisGO:00488783060.043
organophosphate catabolic processGO:00464344300.043
biological adhesionGO:00226103310.042
regulation of cell migrationGO:00303342890.042
nucleoside triphosphate metabolic processGO:00091414220.041
cell adhesionGO:00071553250.040
nucleotide catabolic processGO:00091664080.040
purine nucleotide catabolic processGO:00061954050.039
regulation of locomotionGO:00400123290.039
g protein coupled receptor signaling pathwayGO:00071862070.037
neuromuscular junction developmentGO:000752830.037
calcium ion homeostasisGO:00550741220.037
ribonucleoside triphosphate catabolic processGO:00092033910.037
nucleoside triphosphate catabolic processGO:00091433940.037
negative regulation of cellular protein metabolic processGO:00322693530.037
multicellular organismal agingGO:001025930.037
ion homeostasisGO:00508012300.036
cell projection organizationGO:00300302520.036
Mouse
purine ribonucleoside triphosphate catabolic processGO:00092073910.035
nervous system developmentGO:00073992930.035
Mouse
positive regulation of developmental processGO:00510943140.035
glycosyl compound catabolic processGO:19016584130.035
purine ribonucleoside triphosphate metabolic processGO:00092054110.035
negative regulation of protein metabolic processGO:00512483910.035
rho protein signal transductionGO:0007266260.034
determination of adult lifespanGO:000834020.034
ribonucleoside triphosphate metabolic processGO:00091994120.034
purine nucleoside triphosphate metabolic processGO:00091444120.034
cation transmembrane transportGO:00986552380.034
immune responseGO:00069553070.034
cytoplasmic transportGO:00164823790.033
purine ribonucleoside catabolic processGO:00461303980.033
positive regulation of hydrolase activityGO:00513453310.033
anatomical structure formation involved in morphogenesisGO:00486462840.033
divalent inorganic cation homeostasisGO:00725071360.033
positive regulation of transportGO:00510503360.032
regulation of nucleotide metabolic processGO:00061402690.032
regulation of establishment of protein localizationGO:00702012420.032
cellular homeostasisGO:00197251960.032
cellular macromolecular complex assemblyGO:00346223240.032
regulation of cellular component biogenesisGO:00440872810.032
regulation of purine nucleotide metabolic processGO:19005422640.032
signal transduction by phosphorylationGO:00230142970.032
single organism cellular localizationGO:19025803320.032
metal ion homeostasisGO:00550651690.031
regulation of protein localizationGO:00328802960.031
cell morphogenesisGO:00009022960.031
Mouse
defense responseGO:00069523150.031
regulation of transferase activityGO:00513383550.031
purine nucleoside catabolic processGO:00061523980.030
positive regulation of protein phosphorylationGO:00019343130.030
response to abiotic stimulusGO:00096283360.030
cellular divalent inorganic cation homeostasisGO:00725031280.030
neurological system processGO:00508771630.030
ribonucleotide catabolic processGO:00092614050.030
single organism cell adhesionGO:00986021790.029
regulation of mapk cascadeGO:00434082620.029
regulation of cellular component movementGO:00512703340.029
vasculature developmentGO:00019441810.029
cellular metal ion homeostasisGO:00068751460.029
blood vessel morphogenesisGO:00485141620.029
regulation of secretion by cellGO:19035301770.028
cellular cation homeostasisGO:00300031630.028
divalent metal ion transportGO:00708381520.028
angiogenesisGO:00015251470.027
mapk cascadeGO:00001652880.027
single organism membrane organizationGO:00448022680.027
membrane organizationGO:00610242920.027
positive regulation of cellular catabolic processGO:00313312840.027
regulation of cell differentiationGO:00455953930.027
lipid metabolic processGO:00066293810.027
regulation of response to external stimulusGO:00321012220.027
regulation of protein kinase activityGO:00458592890.027
guanosine containing compound catabolic processGO:19010692390.027
positive regulation of mapk cascadeGO:00434101900.026
regulation of kinase activityGO:00435493140.026
regulation of small gtpase mediated signal transductionGO:00510561560.026
regulation of purine nucleotide catabolic processGO:00331212050.026
regulation of ras protein signal transductionGO:00465781550.026
oogenesisGO:004847720.026
cardiovascular system developmentGO:00723582620.026
regulation of cell motilityGO:20001452990.026
positive regulation of purine nucleotide metabolic processGO:19005442270.026
nucleoside catabolic processGO:00091644080.025
calcium ion transmembrane transportGO:0070588760.025
mitotic cell cycleGO:00002783260.025
reactive oxygen species metabolic processGO:0072593750.025
cellular response to endogenous stimulusGO:00714953360.025
negative regulation of phosphorus metabolic processGO:00105632670.025
circulatory system developmentGO:00723592620.025
positive regulation of catabolic processGO:00098963100.025
cellular chemical homeostasisGO:00550821800.025
regulation of cell cycleGO:00517263930.025
actin filament based processGO:00300292240.025
positive regulation of nucleotide metabolic processGO:00459812300.024
blood vessel developmentGO:00015681720.024
positive regulation of cell proliferationGO:00082843010.024
taxisGO:00423301570.024
female gamete generationGO:000729220.024
cell developmentGO:00484683280.024
Mouse
positive regulation of cell differentiationGO:00455972110.024
mitotic cell cycle processGO:19030472860.024
cellular calcium ion homeostasisGO:00068741170.024
cellular response to dna damage stimulusGO:00069743790.024
response to oxygen containing compoundGO:19017003690.024
gtp metabolic processGO:00460392390.024
regulation of intracellular transportGO:00323861950.024
cellular component morphogenesisGO:00329893140.023
Mouse
regulation of protein transportGO:00512232130.023
regulation of proteolysisGO:00301622930.023
protein localization to organelleGO:00333652800.023
negative regulation of multicellular organismal processGO:00512413170.023
response to cytokineGO:00340972320.023
positive regulation of nucleoside metabolic processGO:00459791860.023
secretion by cellGO:00329402260.023
protein maturationGO:00516042330.023
cation homeostasisGO:00550801890.023
regulation of ion transportGO:00432691890.023
regulation of nucleotide catabolic processGO:00308112050.022
enzyme linked receptor protein signaling pathwayGO:00071673030.022
negative regulation of catalytic activityGO:00430863350.022
negative regulation of developmental processGO:00510932470.022
regulation of cellular response to stressGO:00801352440.022
vesicle mediated transportGO:00161923710.022
generation of neuronsGO:00486991520.022
Mouse
neurogenesisGO:00220081690.022
Mouse
regulation of ion transmembrane transportGO:00347651320.022
negative regulation of phosphate metabolic processGO:00459362670.022
motor neuron axon guidanceGO:000804520.022
regenerationGO:003109940.022
cellular response to growth factor stimulusGO:00713631970.022
cellular lipid metabolic processGO:00442553030.021
regulation of cell growthGO:00015581350.021
chemotaxisGO:00069351570.021
guanosine containing compound metabolic processGO:19010682440.021
organ formationGO:004864530.021
endomembrane system organizationGO:00102561960.021
response to growth factorGO:00708482050.021
gtp catabolic processGO:00061842370.021
cytokine productionGO:00018162470.021
memoryGO:000761330.021
response to organic cyclic compoundGO:00140702040.021
negative regulation of transportGO:00510511760.021
negative regulation of intracellular signal transductionGO:19025321830.021
regulation of nucleoside metabolic processGO:00091182090.021
regulation of ion transmembrane transporter activityGO:0032412720.021
regulation of cell adhesionGO:00301551660.021
growthGO:00400072020.021
positive regulation of cytokine productionGO:00018191670.020
positive regulation of cell deathGO:00109422630.020
cellular response to oxygen containing compoundGO:19017012760.020
innate immune responseGO:00450871780.020
regulation of cytoskeleton organizationGO:00514931770.020
regulation of cytokine productionGO:00018172320.020
intracellular protein transportGO:00068862700.020
regulation of apoptotic signaling pathwayGO:20012331750.020
negative regulation of protein modification processGO:00314002000.020
cell growthGO:00160491600.020
negative regulation of cellular amine metabolic processGO:003323930.020
regulation of ras gtpase activityGO:00323181280.020
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.019
negative regulation of cell proliferationGO:00082852280.019
positive regulation of transferase activityGO:00513472270.019
regulation of cell cycle processGO:00105642660.019
muscle contractionGO:0006936730.019
dephosphorylationGO:00163112090.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
cellular macromolecule catabolic processGO:00442653800.019
cellular protein complex assemblyGO:00436231880.019
response to nitrogen compoundGO:19016981840.019
regulation of cell morphogenesisGO:00226041530.019
positive regulation of apoptotic processGO:00430652460.019
positive regulation of programmed cell deathGO:00430682490.019
carbohydrate metabolic processGO:00059752070.019
regulation of transporter activityGO:0032409820.019
positive regulation of cell migrationGO:00303351720.019
cell morphogenesis involved in differentiationGO:00009041440.019
Mouse
positive regulation of cytosolic calcium ion concentrationGO:0007204820.019
positive regulation of cell developmentGO:0010720920.019
positive regulation of organelle organizationGO:00106381950.019
regulation of cell developmentGO:00602841610.019
startle responseGO:000196430.019
cellular response to cytokine stimulusGO:00713451810.019
cell activationGO:00017752130.019
negative regulation of protein phosphorylationGO:00019331400.019
segmentationGO:003528240.019
regulation of protein serine threonine kinase activityGO:00719001790.019
positive regulation of cellular component biogenesisGO:00440891580.019
regulation of transmembrane transporter activityGO:0022898740.019
cell projection morphogenesisGO:00488581290.019
Mouse
negative regulation of cellular component organizationGO:00511292350.018
negative regulation of phosphorylationGO:00423261740.018
regulation of gtpase activityGO:00430871800.018
matingGO:000761810.018
neuron differentiationGO:00301821380.018
Mouse
hindbrain developmentGO:003090230.018
associative learningGO:000830610.018
positive regulation of nucleotide catabolic processGO:00308131850.018
muscle system processGO:0003012810.018
regulation of growthGO:00400081650.018
organ morphogenesisGO:00098871470.018
regulation of system processGO:00440571010.018
organonitrogen compound biosynthetic processGO:19015662000.018
regulation of transmembrane transportGO:00347621390.018
regulation of peptidase activityGO:00525471800.018
peptidyl tyrosine phosphorylationGO:00181081700.018
neuron developmentGO:00486661130.017
Mouse
regulation of gtp catabolic processGO:00331241800.017
regulation of immune responseGO:00507762010.017
oxidation reduction processGO:00551143960.017
positive regulation of cellular component movementGO:00512721810.017
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.017
adult locomotory behaviorGO:000834410.017
Mouse
positive regulation of secretion by cellGO:19035321080.017
positive regulation of protein kinase activityGO:00458601900.017
nitrogen compound transportGO:00717051910.017
organic anion transportGO:00157111030.017
cellular response to organic cyclic compoundGO:00714071270.017
negative regulation of hydrolase activityGO:00513461820.017
carbohydrate derivative biosynthetic processGO:19011372070.017
regulation of actin filament based processGO:00329701410.017
cell substrate adhesionGO:00315891320.017
regulation of endopeptidase activityGO:00525481700.017
response to radiationGO:00093141510.017
actin cytoskeleton organizationGO:00300362070.017
regulation of cell projection organizationGO:00313441070.017
negative regulation of cell deathGO:00605483450.016
central nervous system developmentGO:00074171230.016
cardiac muscle cell contractionGO:008600340.016
maintenance of locationGO:00512351120.016
syncytium formation by plasma membrane fusionGO:000076820.016
divalent inorganic cation transportGO:00725111580.016
protein catabolic processGO:00301633250.016
apoptotic signaling pathwayGO:00971902680.016
response to organonitrogen compoundGO:00102431560.016
secretionGO:00469032540.016
ameboidal type cell migrationGO:00016671350.016
regulation of secretionGO:00510461940.016
regulation of angiogenesisGO:0045765920.016
positive regulation of gtp catabolic processGO:00331261660.016
striated muscle contractionGO:0006941520.016
single organismal cell cell adhesionGO:00163371480.016
anion transportGO:00068201610.016
proteolysis involved in cellular protein catabolic processGO:00516032440.015
peptidyl tyrosine modificationGO:00182121700.015
organophosphate biosynthetic processGO:00904071630.015
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.015
regulation of cell activationGO:00508651250.015
sequestering of calcium ionGO:0051208170.015
protein processingGO:00164852260.015
cell cycle phase transitionGO:00447701730.015
blastoderm segmentationGO:000735020.015
protein modification by small protein conjugationGO:00324463420.015
positive regulation of immune system processGO:00026842830.015
regulation of vasculature developmentGO:1901342970.015
response to other organismGO:00517072610.015
spermatid differentiationGO:004851540.015
purine nucleoside monophosphate metabolic processGO:00091261860.015
ribonucleoside monophosphate metabolic processGO:00091611870.015
regulation of reactive oxygen species metabolic processGO:2000377410.015
single organism carbohydrate metabolic processGO:00447231930.015
calcium ion transportGO:00068161470.015
regulation of i kappab kinase nf kappab signalingGO:00431221620.015
epithelium migrationGO:00901321190.015
cytosolic calcium ion homeostasisGO:0051480890.015
immune effector processGO:00022521590.015
leukocyte activationGO:00453211640.015
regulation of actin cytoskeleton organizationGO:00329561160.015
purine ribonucleoside monophosphate metabolic processGO:00091671860.015
nucleoside monophosphate metabolic processGO:00091231910.015
protein targetingGO:00066051870.015
positive regulation of purine nucleotide catabolic processGO:00331231850.015
negative regulation of programmed cell deathGO:00430693210.015
posttranscriptional regulation of gene expressionGO:00106082130.015
positive regulation of protein transportGO:00512221350.015
detection of stimulusGO:0051606850.015
regulation of sequence specific dna binding transcription factor activityGO:00510902110.015
neuron projection developmentGO:00311751060.014
Mouse
response to woundingGO:00096111680.014
positive regulation of kinase activityGO:00336742040.014
cellular protein catabolic processGO:00442572610.014
cell projection assemblyGO:00300311260.014
visual behaviorGO:000763220.014
peripheral nervous system developmentGO:000742220.014
negative regulation of cell cycleGO:00457861930.014
salivary gland morphogenesisGO:000743540.014
sequestering of metal ionGO:0051238240.014
establishment of protein localization to organelleGO:00725941720.014
cell divisionGO:00513011680.014
tissue migrationGO:00901301190.014
regulation of vesicle mediated transportGO:00606271300.014
regulation of cytoplasmic transportGO:19036491490.014
reactive nitrogen species metabolic processGO:200105730.014
nucleocytoplasmic transportGO:00069131760.014
metencephalon developmentGO:002203720.014
positive regulation of proteolysisGO:00458621420.014
circulatory system processGO:00030131130.014
atp metabolic processGO:00460341760.014
cell part morphogenesisGO:00329901370.014
Mouse
regulation of homeostatic processGO:00328441210.014
regulation of epithelial cell migrationGO:0010632930.014
regulation of intracellular protein transportGO:00331571230.014
positive regulation of cell motilityGO:20001471770.014
negative regulation of synaptic transmissionGO:005080520.014
wnt signaling pathwayGO:00160551560.014
positive regulation of cell adhesionGO:0045785840.014
photoreceptor cell differentiationGO:004653020.013
cgmp catabolic processGO:004606930.013
blood circulationGO:00080151130.013
organic hydroxy compound metabolic processGO:19016151470.013
actin filament based movementGO:0030048170.013
cellular response to nitrogen compoundGO:19016991440.013
epithelial cell migrationGO:00106311190.013
nuclear transportGO:00511691790.013
positive regulation of protein serine threonine kinase activityGO:00719021190.013
oocyte developmentGO:004859910.013
plasma membrane organizationGO:00070091150.013
regulation of metal ion transportGO:00109591200.013
regulation of nervous system developmentGO:0051960880.013
microtubule based processGO:00070172100.013
regulation of cell morphogenesis involved in differentiationGO:0010769830.013
lipid biosynthetic processGO:00086101770.013
compound eye developmentGO:004874910.013
actin filament organizationGO:00070151280.013
microtubule cytoskeleton organizationGO:00002261760.013
reactive oxygen species biosynthetic processGO:190340940.013
protein ubiquitinationGO:00165673140.013
lipid localizationGO:00108761060.013
spermatid developmentGO:000728640.013
response to hypoxiaGO:0001666960.013
cardiac muscle contractionGO:0060048340.013
rhythmic behaviorGO:000762220.013
head developmentGO:00603221080.013
response to external biotic stimulusGO:00432072610.013
regulation of anatomical structure sizeGO:00900661010.013
regulation of cysteine type endopeptidase activityGO:20001161270.013
tripartite regional subdivisionGO:000735120.013
protein localization to membraneGO:00726571600.013
negative regulation of transferase activityGO:00513481240.013
regulation of membrane potentialGO:0042391950.013
modification dependent macromolecule catabolic processGO:00436322120.012
anterior posterior axis specificationGO:000994820.012
thymus developmentGO:004853830.012
positive regulation of secretionGO:00510471160.012
negative regulation of locomotionGO:00400131180.012
modification dependent protein catabolic processGO:00199412090.012
negative regulation of apoptotic processGO:00430663160.012
brain developmentGO:0007420970.012
organelle assemblyGO:00709251760.012
cellular response to organonitrogen compoundGO:00714171240.012
endocytosisGO:00068971590.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.012
response to axon injuryGO:004867810.012
dna repairGO:00062811980.012
chromatin organizationGO:00063253510.012
wound healingGO:00420601150.012
regulation of neural precursor cell proliferationGO:200017740.012
i kappab kinase nf kappab signalingGO:00072491660.012
epithelium developmentGO:00604292270.012
regulation of mitotic cell cycleGO:00073461890.012
regulation of response to woundingGO:19030341010.012
regulation of wnt signaling pathwayGO:00301111230.012
monovalent inorganic cation transportGO:00156721280.012
heart contractionGO:0060047620.012
positive regulation of hormone biosynthetic processGO:004688640.012
protein oligomerizationGO:00512591730.012
limbic system developmentGO:002176130.012
positive regulation of reactive oxygen species biosynthetic processGO:190342820.012
regulation of tor signalingGO:0032006300.012
small molecule biosynthetic processGO:00442831570.012
circadian behaviorGO:004851220.012
nerve developmentGO:002167540.012
lymphocyte activationGO:00466491330.012
regulation of cellular response to growth factor stimulusGO:0090287760.012
oocyte differentiationGO:000999420.012
visual learningGO:000854210.012
positive regulation of synaptic transmissionGO:005080640.012
negative regulation of organelle organizationGO:00106391260.012
nucleoside monophosphate catabolic processGO:00091251590.012
mitochondrion organizationGO:00070051560.012
response to lipidGO:00339932060.012
positive regulation of cell cycleGO:00457871400.012
stem cell divisionGO:001714520.012
regulation of synaptic plasticityGO:004816730.011
ubiquitin dependent protein catabolic processGO:00065112060.011
regulation of calcium ion transportGO:0051924790.011
tissue regenerationGO:004224630.011
negative regulation of cell migrationGO:00303361020.011
morphogenesis of a polarized epitheliumGO:000173830.011
positive regulation of immune responseGO:00507781590.011
regulation of defense responseGO:00313471540.011
anatomical structure homeostasisGO:00602491000.011
multicellular organismal signalingGO:0035637340.011
negative regulation of kinase activityGO:00336731060.011
mitotic cell cycle phase transitionGO:00447721620.011
inner ear morphogenesisGO:004247240.011
protein localization to nucleusGO:00345041360.011
regulation of reactive oxygen species biosynthetic processGO:190342630.011
histone modificationGO:00165702510.011
rna processingGO:00063962550.011
hemopoiesisGO:00300971800.011
regulation of cardiac muscle cell proliferationGO:006004340.011
regulation of protein maturationGO:19033171500.011
endosomal transportGO:00161971290.011
protein secretionGO:0009306980.011
receptor metabolic processGO:0043112810.011
transmission of nerve impulseGO:0019226110.011
sensory perception of painGO:001923340.011
activation of immune responseGO:00022531140.011
response to fungusGO:000962040.011
positive regulation of vasoconstrictionGO:004590730.011
morphogenesis of embryonic epitheliumGO:001633140.011
anterior posterior axis specification embryoGO:000859520.011
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.011
regulation of endothelial cell migrationGO:0010594670.011
lipid transportGO:0006869900.011
regulation of dephosphorylationGO:0035303960.011
specification of organ identityGO:001009230.011
protein importGO:00170381300.011
positive regulation of peptidase activityGO:0010952880.011
hematopoietic or lymphoid organ developmentGO:00485341860.011
positive regulation of gtpase activityGO:00435471660.011
regulation of dna metabolic processGO:00510521530.011
proteasomal protein catabolic processGO:00104981760.011
response to inorganic substanceGO:00100351270.011
regulation of phosphatase activityGO:0010921810.011
positive regulation of locomotionGO:00400171860.011
inflammatory responseGO:0006954790.011
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.011
positive regulation of erk1 and erk2 cascadeGO:0070374750.010
response to transforming growth factor betaGO:0071559940.010
cranial nerve developmentGO:002154540.010
purine ribonucleoside monophosphate catabolic processGO:00091691580.010
protein homooligomerizationGO:00512601000.010
action potentialGO:0001508340.010
sensory perceptionGO:00076001030.010
cerebellum developmentGO:002154920.010
regulation of neuron projection developmentGO:0010975570.010
positive regulation of endopeptidase activityGO:0010950840.010
fatty acid metabolic processGO:00066311150.010
actin mediated cell contractionGO:0070252120.010
atp catabolic processGO:00062001570.010

PREX2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:8634310.024
central nervous system diseaseDOID:3311860.024
sensory system diseaseDOID:00501552030.023
eye and adnexa diseaseDOID:14921500.023
eye diseaseDOID:56141490.022
cancerDOID:1621670.019
disease of cellular proliferationDOID:145661740.019
disease of metabolismDOID:00146672950.018
organ system cancerDOID:00506861640.017
musculoskeletal system diseaseDOID:172230.017
inherited metabolic disorderDOID:6552420.015
retinal diseaseDOID:56791180.015
disease of mental healthDOID:150700.013
retinal degenerationDOID:8466890.012
neurodegenerative diseaseDOID:12891020.012
immune system diseaseDOID:29141550.012
muscular diseaseDOID:00800001140.012
cardiovascular system diseaseDOID:12871060.011
bone diseaseDOID:0080001880.010
connective tissue diseaseDOID:651090.010
brain diseaseDOID:936730.010