Homo sapiens

0 known processes

PLEKHG4

pleckstrin homology domain containing, family G (with RhoGef domain) member 4

(Aliases: DKFZp434I216,ARHGEF44,SCA4,PRTPHN1)

PLEKHG4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
post embryonic developmentGO:000979120.076
cellular amino acid metabolic processGO:00065201160.050
determination of adult lifespanGO:000834020.047
cellular ketone metabolic processGO:0042180800.044
multicellular organismal agingGO:001025930.044
regulation of cellular amine metabolic processGO:0033238110.044
cellular amine metabolic processGO:0044106410.043
regulation of cellular amino acid metabolic processGO:000652160.041
amine metabolic processGO:0009308440.040
neuromuscular junction developmentGO:000752830.040
regulation of cellular ketone metabolic processGO:0010565500.039
regulation of cell cycleGO:00517263930.038
locomotory behaviorGO:000762610.035
positive regulation of cellular amino acid metabolic processGO:004576430.035
protein catabolic processGO:00301633250.033
oogenesisGO:004847720.033
negative regulation of cell deathGO:00605483450.033
female gamete generationGO:000729220.033
cellular macromolecule catabolic processGO:00442653800.033
positive regulation of cellular amine metabolic processGO:003324070.032
negative regulation of protein metabolic processGO:00512483910.032
actin filament based processGO:00300292240.031
ras protein signal transductionGO:0007265730.031
cell morphogenesisGO:00009022960.030
positive regulation of cellular component organizationGO:00511303760.030
negative regulation of multicellular organismal processGO:00512413170.030
regulation of cell differentiationGO:00455953930.030
response to abiotic stimulusGO:00096283360.029
single organism cellular localizationGO:19025803320.029
negative regulation of cellular protein metabolic processGO:00322693530.029
cellular protein catabolic processGO:00442572610.029
negative regulation of apoptotic processGO:00430663160.029
purine ribonucleoside metabolic processGO:00461284370.028
regulation of cellular component movementGO:00512703340.028
immune responseGO:00069553070.028
regulation of kinase activityGO:00435493140.028
negative regulation of programmed cell deathGO:00430693210.028
small gtpase mediated signal transductionGO:0007264780.027
negative regulation of catalytic activityGO:00430863350.027
regulation of response to external stimulusGO:00321012220.027
biological adhesionGO:00226103310.027
cellular response to endogenous stimulusGO:00714953360.027
purine containing compound catabolic processGO:00725234110.026
defense responseGO:00069523150.026
ribonucleoside triphosphate catabolic processGO:00092033910.026
positive regulation of hydrolase activityGO:00513453310.026
regenerationGO:003109940.026
proteolysis involved in cellular protein catabolic processGO:00516032440.026
system processGO:00030083490.026
regulation of protein localizationGO:00328802960.026
regulation of transferase activityGO:00513383550.026
cell adhesionGO:00071553250.025
anatomical structure formation involved in morphogenesisGO:00486462840.025
regulation of locomotionGO:00400123290.025
segmentationGO:003528240.025
nervous system developmentGO:00073992930.025
memoryGO:000761330.025
positive regulation of cell proliferationGO:00082843010.025
cell developmentGO:00484683280.025
cytoplasmic transportGO:00164823790.025
regulation of anatomical structure morphogenesisGO:00226032860.025
cell projection organizationGO:00300302520.024
response to cytokineGO:00340972320.024
regulation of establishment of protein localizationGO:00702012420.024
cellular response to dna damage stimulusGO:00069743790.024
positive regulation of phosphorylationGO:00423273940.024
rho protein signal transductionGO:0007266260.024
purine nucleoside triphosphate catabolic processGO:00091463920.024
oxidation reduction processGO:00551143960.024
protein maturationGO:00516042330.024
cellular component morphogenesisGO:00329893140.024
positive regulation of transportGO:00510503360.024
mitotic cell cycleGO:00002783260.024
organophosphate catabolic processGO:00464344300.024
single organism membrane organizationGO:00448022680.023
negative regulation of phosphorus metabolic processGO:00105632670.023
chemical homeostasisGO:00488783060.023
lipid metabolic processGO:00066293810.023
regulation of protein kinase activityGO:00458592890.023
purine nucleoside catabolic processGO:00061523980.023
positive regulation of catabolic processGO:00098963100.023
cation transportGO:00068123310.023
ribonucleoside catabolic processGO:00424544060.023
protein modification by small protein conjugationGO:00324463420.023
cellular macromolecular complex assemblyGO:00346223240.023
purine nucleoside triphosphate metabolic processGO:00091444120.023
vesicle mediated transportGO:00161923710.022
transmembrane transportGO:00550853990.022
nucleoside triphosphate metabolic processGO:00091414220.022
adult locomotory behaviorGO:000834410.022
negative regulation of phosphate metabolic processGO:00459362670.022
protein localization to organelleGO:00333652800.022
regulation of proteolysisGO:00301622930.022
protein ubiquitinationGO:00165673140.022
nucleoside phosphate catabolic processGO:19012924120.022
nucleotide catabolic processGO:00091664080.022
microtubule based processGO:00070172100.022
regulation of cell motilityGO:20001452990.022
membrane organizationGO:00610242920.022
regulation of cell cycle processGO:00105642660.021
glycosyl compound catabolic processGO:19016584130.021
modification dependent protein catabolic processGO:00199412090.021
peripheral nervous system developmentGO:000742220.021
purine ribonucleoside triphosphate catabolic processGO:00092073910.021
modification dependent macromolecule catabolic processGO:00436322120.021
nucleoside triphosphate catabolic processGO:00091433940.021
cellular lipid metabolic processGO:00442553030.021
innate immune responseGO:00450871780.021
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.021
metal ion transportGO:00300012720.021
purine ribonucleoside catabolic processGO:00461303980.021
protein processingGO:00164852260.021
ribonucleoside triphosphate metabolic processGO:00091994120.021
purine nucleotide catabolic processGO:00061954050.021
regulation of nucleotide metabolic processGO:00061402690.021
positive regulation of cell differentiationGO:00455972110.021
purine ribonucleoside triphosphate metabolic processGO:00092054110.021
positive regulation of programmed cell deathGO:00430682490.020
purine ribonucleotide catabolic processGO:00091544040.020
regulation of cell migrationGO:00303342890.020
ubiquitin dependent protein catabolic processGO:00065112060.020
morphogenesis of embryonic epitheliumGO:001633140.020
regulation of protein transportGO:00512232130.020
enzyme linked receptor protein signaling pathwayGO:00071673030.020
regulation of cellular component biogenesisGO:00440872810.020
oocyte developmentGO:004859910.020
positive regulation of cell deathGO:00109422630.020
signal transduction by phosphorylationGO:00230142970.020
regulation of cellular response to stressGO:00801352440.020
rhythmic behaviorGO:000762220.019
intracellular protein transportGO:00068862700.019
positive regulation of purine nucleotide metabolic processGO:19005442270.019
hindbrain developmentGO:003090230.019
ribonucleotide catabolic processGO:00092614050.019
response to oxygen containing compoundGO:19017003690.019
positive regulation of protein phosphorylationGO:00019343130.019
positive regulation of immune system processGO:00026842830.019
guanosine containing compound metabolic processGO:19010682440.019
oocyte differentiationGO:000999420.019
posttranscriptional regulation of gene expressionGO:00106082130.019
dephosphorylationGO:00163112090.019
mapk cascadeGO:00001652880.019
regulation of purine nucleotide metabolic processGO:19005422640.019
positive regulation of synaptic transmissionGO:005080640.019
positive regulation of nucleotide metabolic processGO:00459812300.019
negative regulation of hydrolase activityGO:00513461820.019
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.018
cellular protein complex assemblyGO:00436231880.018
mitotic cell cycle processGO:19030472860.018
chromatin organizationGO:00063253510.018
endomembrane system organizationGO:00102561960.018
positive regulation of apoptotic processGO:00430652460.018
regulation of protein maturationGO:19033171500.018
response to growth factorGO:00708482050.018
regulation of intracellular transportGO:00323861950.018
positive regulation of cellular component movementGO:00512721810.018
positive regulation of developmental processGO:00510943140.018
apoptotic signaling pathwayGO:00971902680.018
negative regulation of cell proliferationGO:00082852280.018
cellular response to growth factor stimulusGO:00713631970.018
cardiac muscle cell contractionGO:008600340.018
embryonic epithelial tube formationGO:000183840.018
rna processingGO:00063962550.018
negative regulation of developmental processGO:00510932470.018
negative regulation of cellular component organizationGO:00511292350.018
negative regulation of intracellular signal transductionGO:19025321830.018
blastoderm segmentationGO:000735020.018
carbohydrate derivative biosynthetic processGO:19011372070.018
nucleoside catabolic processGO:00091644080.017
negative regulation of cellular amino acid metabolic processGO:004576320.017
anterior posterior axis specificationGO:000994820.017
regulation of mapk cascadeGO:00434082620.017
organelle assemblyGO:00709251760.017
nitrogen compound transportGO:00717051910.017
regulation of cell growthGO:00015581350.017
mitochondrion organizationGO:00070051560.017
ion transmembrane transportGO:00342203380.017
organ formationGO:004864530.017
regulation of cytokine productionGO:00018172320.017
regulation of protein catabolic processGO:00421761550.017
negative regulation of cellular amine metabolic processGO:003323930.017
proteasomal protein catabolic processGO:00104981760.017
compound eye developmentGO:004874910.017
regulation of immune responseGO:00507762010.017
inner ear morphogenesisGO:004247240.017
regulation of nucleoside metabolic processGO:00091182090.017
gtp metabolic processGO:00460392390.017
positive regulation of cellular catabolic processGO:00313312840.017
regulation of peptidase activityGO:00525471800.017
cellular response to cytokine stimulusGO:00713451810.017
single organism cell adhesionGO:00986021790.017
positive regulation of organelle organizationGO:00106381950.017
microtubule cytoskeleton organizationGO:00002261760.017
regulation of mitotic cell cycleGO:00073461890.017
regulation of purine nucleotide catabolic processGO:00331212050.017
organonitrogen compound biosynthetic processGO:19015662000.017
thymus developmentGO:004853830.017
wnt signaling pathwayGO:00160551560.017
regulation of cell adhesionGO:00301551660.017
secretionGO:00469032540.017
regulation of sequence specific dna binding transcription factor activityGO:00510902110.017
release of cytoplasmic sequestered nf kappabGO:000858840.017
carbohydrate metabolic processGO:00059752070.017
regulation of meiotic cell cycleGO:005144540.016
negative regulation of protein modification processGO:00314002000.016
cellular response to oxygen containing compoundGO:19017012760.016
regulation of cytoskeleton organizationGO:00514931770.016
cell growthGO:00160491600.016
positive regulation of purine nucleotide catabolic processGO:00331231850.016
neurological system processGO:00508771630.016
spermatid differentiationGO:004851540.016
cytokine productionGO:00018162470.016
reactive oxygen species biosynthetic processGO:190340940.016
negative regulation of cell cycleGO:00457861930.016
single organism carbohydrate metabolic processGO:00447231930.016
neurotransmitter secretionGO:000726940.016
metencephalon developmentGO:002203720.016
protein oligomerizationGO:00512591730.016
motor neuron axon guidanceGO:000804520.016
positive regulation of nucleotide catabolic processGO:00308131850.016
ion homeostasisGO:00508012300.016
maintenance of locationGO:00512351120.016
positive regulation of cell migrationGO:00303351720.016
positive regulation of transferase activityGO:00513472270.016
response to biotic stimulusGO:00096072760.016
circadian behaviorGO:004851220.016
response to radiationGO:00093141510.016
circulatory system developmentGO:00723592620.016
cation transmembrane transportGO:00986552380.016
regulation of endopeptidase activityGO:00525481700.016
chromatin modificationGO:00165682980.016
growthGO:00400072020.016
gtp catabolic processGO:00061842370.016
regulation of protein processingGO:00706131500.016
protein targetingGO:00066051870.016
meiosis iGO:000712740.015
positive regulation of locomotionGO:00400171860.015
regulation of nucleotide catabolic processGO:00308112050.015
associative learningGO:000830610.015
neuroblast proliferationGO:000740540.015
cell substrate adhesionGO:00315891320.015
regulation of cell morphogenesisGO:00226041530.015
nuclear transportGO:00511691790.015
monocarboxylic acid metabolic processGO:00327871850.015
negative regulation of phosphorylationGO:00423261740.015
inorganic cation transmembrane transportGO:00986621940.015
g protein coupled receptor signaling pathwayGO:00071862070.015
positive regulation of protein transportGO:00512221350.015
organ morphogenesisGO:00098871470.015
response to fungusGO:000962040.015
hemopoiesisGO:00300971800.015
cell activationGO:00017752130.015
response to other organismGO:00517072610.015
positive regulation of nucleoside metabolic processGO:00459791860.015
negative regulation of protein maturationGO:19033181420.015
i kappab kinase nf kappab signalingGO:00072491660.015
negative regulation of immune system processGO:00026831360.015
regulation of neural precursor cell proliferationGO:200017740.015
nerve developmentGO:002167540.015
histone modificationGO:00165702510.015
morphogenesis of a polarized epitheliumGO:000173830.015
regulation of i kappab kinase nf kappab signalingGO:00431221620.015
positive regulation of kinase activityGO:00336742040.015
cardiovascular system developmentGO:00723582620.015
small molecule biosynthetic processGO:00442831570.015
positive regulation of cell motilityGO:20001471770.015
glycoprotein metabolic processGO:00091001100.015
spermatid developmentGO:000728640.015
response to external biotic stimulusGO:00432072610.015
reactive oxygen species metabolic processGO:0072593750.014
negative regulation of protein processingGO:00109551420.014
epithelium developmentGO:00604292270.014
regulation of gtpase activityGO:00430871800.014
actin mediated cell contractionGO:0070252120.014
response to woundingGO:00096111680.014
cell cycle phase transitionGO:00447701730.014
reactive nitrogen species metabolic processGO:200105730.014
nucleocytoplasmic transportGO:00069131760.014
regulation of cytoplasmic transportGO:19036491490.014
regulation of cell developmentGO:00602841610.014
protein localization to nucleusGO:00345041360.014
actin cytoskeleton organizationGO:00300362070.014
positive regulation of gtp catabolic processGO:00331261660.014
secretion by cellGO:00329402260.014
anterior posterior axis specification embryoGO:000859520.014
syncytium formation by plasma membrane fusionGO:000076820.014
salivary gland morphogenesisGO:000743540.014
male genitalia developmentGO:003053910.014
positive regulation of mapk cascadeGO:00434101900.014
rna interferenceGO:001624640.014
protein localization to membraneGO:00726571600.014
covalent chromatin modificationGO:00165692540.014
macromolecule methylationGO:0043414970.014
regulation of ras protein signal transductionGO:00465781550.014
actin filament based movementGO:0030048170.014
cell projection assemblyGO:00300311260.014
matingGO:000761810.014
sensory perception of smellGO:000760820.014
regulation of intracellular protein transportGO:00331571230.014
regulation of defense responseGO:00313471540.014
response to axon injuryGO:004867810.014
neural tube formationGO:000184130.014
multi organism cellular processGO:00447641560.014
tripartite regional subdivisionGO:000735120.014
postsynaptic membrane organizationGO:000194120.014
cell fate determinationGO:000170930.013
negative regulation of protein phosphorylationGO:00019331400.013
inorganic ion transmembrane transportGO:00986602310.013
guanosine containing compound catabolic processGO:19010692390.013
lipid biosynthetic processGO:00086101770.013
negative regulation of transportGO:00510511760.013
regulation of growthGO:00400081650.013
regulation of cysteine type endopeptidase activityGO:20001161270.013
startle responseGO:000196430.013
neurogenesisGO:00220081690.013
anion transportGO:00068201610.013
positive regulation of gtpase activityGO:00435471660.013
positive regulation of cytokine productionGO:00018191670.013
positive regulation of proteolysisGO:00458621420.013
cation homeostasisGO:00550801890.013
sex determinationGO:000753030.013
regulation of reactive oxygen species biosynthetic processGO:190342630.013
establishment of planar polarityGO:000173630.013
peptidyl tyrosine modificationGO:00182121700.013
positive regulation of protein kinase activityGO:00458601900.013
immune system developmentGO:00025201950.013
regulation of secretion by cellGO:19035301770.013
mitotic cell cycle phase transitionGO:00447721620.013
neural tube closureGO:000184330.013
endosomal transportGO:00161971290.013
regulation of synaptic plasticityGO:004816730.013
primary neural tube formationGO:001402030.013
epithelium migrationGO:00901321190.013
forebrain generation of neuronsGO:002187230.013
limbic system developmentGO:002176130.012
cellular homeostasisGO:00197251960.012
response to lipidGO:00339932060.012
cellular chemical homeostasisGO:00550821800.012
cell divisionGO:00513011680.012
positive regulation of cellular component biogenesisGO:00440891580.012
spinal cord developmentGO:002151040.012
negative regulation of transferase activityGO:00513481240.012
regulation of protein serine threonine kinase activityGO:00719001790.012
regulation of transcription from rna polymerase ii promoter mitoticGO:004602110.012
specification of organ identityGO:001009230.012
organophosphate biosynthetic processGO:00904071630.012
defense response to fungusGO:005083240.012
tube closureGO:006060630.012
ribonucleoside monophosphate metabolic processGO:00091611870.012
tissue regenerationGO:004224630.012
metal ion homeostasisGO:00550651690.012
protein homooligomerizationGO:00512601000.012
response to organic cyclic compoundGO:00140702040.012
ameboidal type cell migrationGO:00016671350.012
carboxylic acid biosynthetic processGO:0046394970.012
regulation of small gtpase mediated signal transductionGO:00510561560.012
positive regulation of immune responseGO:00507781590.012
chemotaxisGO:00069351570.012
regulation of apoptotic signaling pathwayGO:20012331750.012
visual behaviorGO:000763220.012
organic acid biosynthetic processGO:0016053970.012
positive regulation of transcription from rna polymerase ii promoter during mitosisGO:004602210.012
embryonic forelimb morphogenesisGO:003511540.012
establishment of protein localization to organelleGO:00725941720.012
intrinsic apoptotic signaling pathwayGO:00971931270.012
myoblast fusionGO:000752010.012
regulation of secretionGO:00510461940.012
regulation of transcription during mitosisGO:004589620.012
regulation of actin filament based processGO:00329701410.012
epidermis morphogenesisGO:004873030.012
phototransduction visible lightGO:000760320.012
stem cell divisionGO:001714520.012
glial cell migrationGO:000834740.012
negative regulation of cell cycle processGO:00109481210.012
protein autophosphorylationGO:00467771230.012
cellular ion homeostasisGO:00068731680.012
rna splicingGO:00083801310.012
regulation of ion transportGO:00432691890.012
generation of neuronsGO:00486991520.012
epithelial tube branching involved in lung morphogenesisGO:006044140.012
cerebellum developmentGO:002154920.012
hematopoietic or lymphoid organ developmentGO:00485341860.012
cell projection morphogenesisGO:00488581290.012
organelle fissionGO:00482851490.012
positive regulation of reactive oxygen species biosynthetic processGO:190342820.012
synaptic transmission cholinergicGO:000727120.012
regulation of cell cycle phase transitionGO:19019871260.012
regulation of multi organism processGO:00439001570.012
engulfment of apoptotic cellGO:004365220.012
monovalent inorganic cation transportGO:00156721280.011
photoreceptor cell differentiationGO:004653020.011
cell part morphogenesisGO:00329901370.011
purine ribonucleoside monophosphate metabolic processGO:00091671860.011
establishment of tissue polarityGO:000716430.011
positive regulation of cell developmentGO:0010720920.011
regulation of protein complex assemblyGO:00432541470.011
methylationGO:00322591060.011
central nervous system developmentGO:00074171230.011
epithelial cell differentiationGO:00308551410.011
dna repairGO:00062811980.011
symbiosis encompassing mutualism through parasitismGO:00444031560.011
positive regulation of gliogenesisGO:001401540.011
establishment or maintenance of bipolar cell polarityGO:006124520.011
t cell differentiation in thymusGO:003307740.011
positive regulation of transcription during mitosisGO:004589720.011
forelimb morphogenesisGO:003513640.011
visual learningGO:000854210.011
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.011
establishment or maintenance of apical basal cell polarityGO:003508820.011
regulation of gtp catabolic processGO:00331241800.011
negative regulation of synaptic transmissionGO:005080520.011
somitogenesisGO:000175620.011
blastocyst developmentGO:000182430.011
myosin filament assemblyGO:003103420.011
regulation of ras gtpase activityGO:00323181280.011
protein acylationGO:00435431380.011
sequestering of metal ionGO:0051238240.011
cellular cation homeostasisGO:00300031630.011
long term memoryGO:000761620.011
regulation of glial cell proliferationGO:006025140.011
regulation of hormone levelsGO:00108171250.011
regulation of wnt signaling pathwayGO:00301111230.011
blastocyst formationGO:000182530.011
viral processGO:00160321460.011
organic hydroxy compound metabolic processGO:19016151470.011
endocytosisGO:00068971590.011
single organismal cell cell adhesionGO:00163371480.011
neuron projection regenerationGO:003110210.011
mrna metabolic processGO:00160711750.011
taxisGO:00423301570.011
developmental programmed cell deathGO:001062330.011
post embryonic organ developmentGO:004856910.011
regulation of reactive oxygen species metabolic processGO:2000377410.011
regulation of meiosisGO:004002030.011
somatic stem cell maintenanceGO:003501940.011
lung alveolus developmentGO:004828640.011
negative regulation of locomotionGO:00400131180.011
regulation of postsynaptic membrane potentialGO:006007810.011
atp metabolic processGO:00460341760.011
nucleoside monophosphate metabolic processGO:00091231910.011
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.011
regulation of membrane potentialGO:0042391950.011
cell cell signalingGO:00072671550.011
epithelial cell migrationGO:00106311190.011
regulation of dna metabolic processGO:00510521530.011
regulation of protein stabilityGO:0031647870.011
hematopoietic stem cell differentiationGO:006021840.011
defense response to other organismGO:00985421290.011
divalent inorganic cation homeostasisGO:00725071360.011
negative regulation of cell differentiationGO:00455961710.011
regulation of neurotransmitter secretionGO:004692830.011
cranial nerve developmentGO:002154540.011
actin filament organizationGO:00070151280.011
sleepGO:003043120.011
golgi vesicle transportGO:0048193800.011
positive regulation of secretionGO:00510471160.011
negative regulation of kinase activityGO:00336731060.011
peptidyl tyrosine phosphorylationGO:00181081700.011
extrinsic apoptotic signaling pathwayGO:00971911190.011
head developmentGO:00603221080.011
positive regulation of intracellular transportGO:00323881040.011
tissue migrationGO:00901301190.011
positive regulation of neural precursor cell proliferationGO:200017920.011
hindlimb morphogenesisGO:003513720.011
alcohol metabolic processGO:00060661140.011
positive regulation of ras gtpase activityGO:00323201170.011
regulation of vesicle mediated transportGO:00606271300.011
fatty acid metabolic processGO:00066311150.010
striated muscle contractionGO:0006941520.010
cell morphogenesis involved in differentiationGO:00009041440.010
forebrain neuron differentiationGO:002187930.010

PLEKHG4 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.030
disease of metabolismDOID:00146672950.027
inherited metabolic disorderDOID:6552420.021
central nervous system diseaseDOID:3311860.020
nervous system diseaseDOID:8634310.020
sensory system diseaseDOID:00501552030.020
disease of cellular proliferationDOID:145661740.019
connective tissue diseaseDOID:651090.018
cancerDOID:1621670.018
eye and adnexa diseaseDOID:14921500.017
organ system cancerDOID:00506861640.017
bone diseaseDOID:0080001880.016
neurodegenerative diseaseDOID:12891020.015
muscular diseaseDOID:00800001140.015
muscle tissue diseaseDOID:661130.015
immune system diseaseDOID:29141550.014
eye diseaseDOID:56141490.013
cardiovascular system diseaseDOID:12871060.013
myopathyDOID:4231040.013
retinal diseaseDOID:56791180.012
brain diseaseDOID:936730.011
retinal degenerationDOID:8466890.011