Homo sapiens

8 known processes

PLEKHM1

pleckstrin homology domain containing, family M (with RUN domain) member 1

(Aliases: OPTB6,KIAA0356,AP162,B2)

PLEKHM1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
post embryonic developmentGO:000979120.093
response to oxygen containing compoundGO:19017003690.060
single organism cellular localizationGO:19025803320.054
mitotic cell cycleGO:00002783260.053
glycosyl compound catabolic processGO:19016584130.051
mitotic cell cycle processGO:19030472860.051
organophosphate catabolic processGO:00464344300.050
nucleoside phosphate catabolic processGO:19012924120.048
nucleotide catabolic processGO:00091664080.047
regulation of cellular component biogenesisGO:00440872810.046
membrane organizationGO:00610242920.044
regulation of cellular amino acid metabolic processGO:000652160.044
nucleoside triphosphate catabolic processGO:00091433940.043
regulation of cellular ketone metabolic processGO:0010565500.041
amine metabolic processGO:0009308440.041
purine ribonucleoside catabolic processGO:00461303980.041
multicellular organismal agingGO:001025930.041
regulation of cell cycleGO:00517263930.041
cellular amine metabolic processGO:0044106410.040
purine containing compound catabolic processGO:00725234110.039
lipid metabolic processGO:00066293810.039
positive regulation of cellular catabolic processGO:00313312840.038
ribonucleoside triphosphate catabolic processGO:00092033910.038
determination of adult lifespanGO:000834020.038
cytoplasmic transportGO:00164823790.038
cellular ketone metabolic processGO:0042180800.038
response to lipidGO:00339932060.037
ribonucleoside catabolic processGO:00424544060.037
nucleoside catabolic processGO:00091644080.037
female gamete generationGO:000729220.036
intracellular protein transportGO:00068862700.035
cellular lipid metabolic processGO:00442553030.034
locomotory behaviorGO:000762610.034
nucleoside triphosphate metabolic processGO:00091414220.033
purine nucleoside catabolic processGO:00061523980.033
oogenesisGO:004847720.033
purine nucleoside triphosphate metabolic processGO:00091444120.033
regulation of proteolysisGO:00301622930.033
single organism membrane organizationGO:00448022680.032
positive regulation of catabolic processGO:00098963100.032
protein processingGO:00164852260.032
negative regulation of cellular protein metabolic processGO:00322693530.031
cellular macromolecule catabolic processGO:00442653800.031
gtp catabolic processGO:00061842370.031
cell cycle phase transitionGO:00447701730.031
establishment of protein localization to membraneGO:00901501210.031
cellular amino acid metabolic processGO:00065201160.030
response to other organismGO:00517072610.030
purine ribonucleoside triphosphate catabolic processGO:00092073910.030
response to hormoneGO:00097251750.030
positive regulation of cellular amine metabolic processGO:003324070.030
gtp metabolic processGO:00460392390.030
transmembrane transportGO:00550853990.030
ribonucleotide catabolic processGO:00092614050.029
signal transduction by phosphorylationGO:00230142970.029
positive regulation of cellular amino acid metabolic processGO:004576430.029
system processGO:00030083490.029
protein localization to membraneGO:00726571600.029
positive regulation of cell deathGO:00109422630.029
regulation of transferase activityGO:00513383550.029
positive regulation of cellular component organizationGO:00511303760.029
regulation of nucleotide metabolic processGO:00061402690.029
endomembrane system organizationGO:00102561960.029
positive regulation of hydrolase activityGO:00513453310.028
negative regulation of cell deathGO:00605483450.028
response to organic cyclic compoundGO:00140702040.028
negative regulation of catalytic activityGO:00430863350.027
guanosine containing compound catabolic processGO:19010692390.027
positive regulation of phosphorylationGO:00423273940.027
regenerationGO:003109940.026
mitotic cell cycle phase transitionGO:00447721620.026
protein maturationGO:00516042330.026
regulation of cellular response to stressGO:00801352440.026
regulation of cell cycle processGO:00105642660.026
purine ribonucleotide catabolic processGO:00091544040.026
positive regulation of gtp catabolic processGO:00331261660.026
protein targetingGO:00066051870.026
ribonucleoside triphosphate metabolic processGO:00091994120.026
protein localization to organelleGO:00333652800.025
positive regulation of programmed cell deathGO:00430682490.025
vesicle mediated transportGO:00161923710.025
small gtpase mediated signal transductionGO:0007264780.025
cellular response to oxygen containing compoundGO:19017012760.025
ion transmembrane transportGO:00342203380.025
purine nucleoside triphosphate catabolic processGO:00091463920.024
response to abiotic stimulusGO:00096283360.024
guanosine containing compound metabolic processGO:19010682440.024
glycerolipid metabolic processGO:00464861070.024
response to external biotic stimulusGO:00432072610.024
apoptotic signaling pathwayGO:00971902680.024
regulation of nucleoside metabolic processGO:00091182090.023
purine ribonucleoside metabolic processGO:00461284370.023
cellular macromolecular complex assemblyGO:00346223240.023
protein oligomerizationGO:00512591730.023
regulation of kinase activityGO:00435493140.023
regulation of protein kinase activityGO:00458592890.023
purine nucleotide catabolic processGO:00061954050.023
positive regulation of apoptotic processGO:00430652460.023
proteolysis involved in cellular protein catabolic processGO:00516032440.023
positive regulation of transferase activityGO:00513472270.023
cellular protein catabolic processGO:00442572610.023
negative regulation of programmed cell deathGO:00430693210.022
oxidation reduction processGO:00551143960.022
positive regulation of gtpase activityGO:00435471660.022
response to oxidative stressGO:00069791210.022
negative regulation of intracellular signal transductionGO:19025321830.022
reactive oxygen species metabolic processGO:0072593750.022
growthGO:00400072020.021
negative regulation of protein metabolic processGO:00512483910.021
regulation of endopeptidase activityGO:00525481700.021
positive regulation of purine nucleotide catabolic processGO:00331231850.021
immune responseGO:00069553070.020
protein ubiquitinationGO:00165673140.020
response to biotic stimulusGO:00096072760.020
ion homeostasisGO:00508012300.020
rho protein signal transductionGO:0007266260.020
regulation of response to external stimulusGO:00321012220.020
regulation of purine nucleotide catabolic processGO:00331212050.020
actin filament based processGO:00300292240.019
purine ribonucleoside triphosphate metabolic processGO:00092054110.019
positive regulation of organelle organizationGO:00106381950.019
protein modification by small protein conjugationGO:00324463420.019
oocyte differentiationGO:000999420.019
negative regulation of phosphate metabolic processGO:00459362670.019
positive regulation of protein phosphorylationGO:00019343130.019
regulation of cysteine type endopeptidase activityGO:20001161270.019
chemical homeostasisGO:00488783060.019
endosomal transportGO:00161971290.019
positive regulation of developmental processGO:00510943140.019
positive regulation of nucleotide metabolic processGO:00459812300.019
positive regulation of kinase activityGO:00336742040.019
g1 s transition of mitotic cell cycleGO:0000082780.019
establishment of protein localization to organelleGO:00725941720.019
protein catabolic processGO:00301633250.019
regulation of cell differentiationGO:00455953930.019
cell adhesionGO:00071553250.018
regulation of purine nucleotide metabolic processGO:19005422640.018
regulation of nucleotide catabolic processGO:00308112050.018
carbohydrate metabolic processGO:00059752070.018
microtubule based processGO:00070172100.018
negative regulation of cellular component organizationGO:00511292350.018
secretion by cellGO:00329402260.018
ras protein signal transductionGO:0007265730.018
positive regulation of purine nucleotide metabolic processGO:19005442270.018
cell morphogenesisGO:00009022960.018
negative regulation of phosphorus metabolic processGO:00105632670.018
cellular response to dna damage stimulusGO:00069743790.018
posttranscriptional regulation of gene expressionGO:00106082130.017
modification dependent protein catabolic processGO:00199412090.017
biological adhesionGO:00226103310.017
regulation of cellular amine metabolic processGO:0033238110.017
organelle assemblyGO:00709251760.017
regulation of gtpase activityGO:00430871800.017
actin cytoskeleton organizationGO:00300362070.017
positive regulation of cellular component biogenesisGO:00440891580.017
positive regulation of cell proliferationGO:00082843010.017
negative regulation of cellular amino acid metabolic processGO:004576320.017
positive regulation of proteolysisGO:00458621420.016
regulation of gtp catabolic processGO:00331241800.016
mapk cascadeGO:00001652880.016
negative regulation of protein modification processGO:00314002000.016
positive regulation of nucleotide catabolic processGO:00308131850.016
hemopoiesisGO:00300971800.016
regulation of protein localizationGO:00328802960.016
regulation of growthGO:00400081650.016
lipid localizationGO:00108761060.016
memoryGO:000761330.016
negative regulation of protein maturationGO:19033181420.016
cellular protein complex assemblyGO:00436231880.016
carbohydrate derivative biosynthetic processGO:19011372070.016
innate immune responseGO:00450871780.016
regulation of immune responseGO:00507762010.016
purine nucleoside monophosphate metabolic processGO:00091261860.016
cell growthGO:00160491600.016
positive regulation of immune responseGO:00507781590.016
ubiquitin dependent protein catabolic processGO:00065112060.016
cellular response to cytokine stimulusGO:00713451810.016
syncytium formation by plasma membrane fusionGO:000076820.015
cellular component morphogenesisGO:00329893140.015
hematopoietic or lymphoid organ developmentGO:00485341860.015
negative regulation of multicellular organismal processGO:00512413170.015
peripheral nervous system developmentGO:000742220.015
nervous system developmentGO:00073992930.015
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.015
negative regulation of cellular amine metabolic processGO:003323930.015
single organism carbohydrate metabolic processGO:00447231930.015
neuromuscular junction developmentGO:000752830.015
cell projection organizationGO:00300302520.015
cytokine productionGO:00018162470.015
cation transportGO:00068123310.015
glycoprotein metabolic processGO:00091001100.015
positive regulation of nucleoside metabolic processGO:00459791860.015
cellular ion homeostasisGO:00068731680.015
regulation of protein maturationGO:19033171500.015
proteasomal protein catabolic processGO:00104981760.015
organophosphate biosynthetic processGO:00904071630.015
neurological system processGO:00508771630.015
dephosphorylationGO:00163112090.015
maintenance of locationGO:00512351120.015
modification dependent macromolecule catabolic processGO:00436322120.015
mitochondrion organizationGO:00070051560.015
negative regulation of organelle organizationGO:00106391260.015
negative regulation of hydrolase activityGO:00513461820.015
defense responseGO:00069523150.015
spermatid developmentGO:000728640.014
positive regulation of protein kinase activityGO:00458601900.014
regulation of neural precursor cell proliferationGO:200017740.014
microtubule cytoskeleton organizationGO:00002261760.014
regulation of mapk cascadeGO:00434082620.014
histone modificationGO:00165702510.014
cellular response to oxidative stressGO:0034599850.014
chromatin modificationGO:00165682980.014
response to nitrogen compoundGO:19016981840.014
cellular response to external stimulusGO:00714961110.014
circadian behaviorGO:004851220.014
response to alcoholGO:0097305640.014
monocarboxylic acid metabolic processGO:00327871850.014
regulation of mitotic cell cycleGO:00073461890.014
covalent chromatin modificationGO:00165692540.014
lipid transportGO:0006869900.014
lipid biosynthetic processGO:00086101770.014
hindbrain developmentGO:003090230.014
phospholipid metabolic processGO:0006644990.014
organelle fissionGO:00482851490.014
oocyte developmentGO:004859910.014
response to organonitrogen compoundGO:00102431560.014
rhythmic behaviorGO:000762220.014
plasma membrane organizationGO:00070091150.014
response to steroid hormoneGO:0048545800.014
cellular cation homeostasisGO:00300031630.013
secretionGO:00469032540.013
positive regulation of secretionGO:00510471160.013
fatty acid metabolic processGO:00066311150.013
defense response to other organismGO:00985421290.013
glycerophospholipid metabolic processGO:0006650840.013
positive regulation of transportGO:00510503360.013
spermatid differentiationGO:004851540.013
cation homeostasisGO:00550801890.013
regulation of small gtpase mediated signal transductionGO:00510561560.013
adult locomotory behaviorGO:000834410.013
regulation of apoptotic signaling pathwayGO:20012331750.013
protein acylationGO:00435431380.013
cellular response to hormone stimulusGO:00328701250.013
glycoprotein biosynthetic processGO:0009101910.013
compound eye developmentGO:004874910.013
response to estrogenGO:0043627470.013
segmentationGO:003528240.013
protein homooligomerizationGO:00512601000.013
extrinsic apoptotic signaling pathwayGO:00971911190.013
autophagyGO:0006914880.013
cellular response to organic cyclic compoundGO:00714071270.013
nucleoside monophosphate metabolic processGO:00091231910.013
regulation of i kappab kinase nf kappab signalingGO:00431221620.013
regulation of cytokine productionGO:00018172320.013
cation transmembrane transportGO:00986552380.013
lymphocyte homeostasisGO:000226040.012
regulation of peptidase activityGO:00525471800.012
reactive oxygen species biosynthetic processGO:190340940.012
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.012
regulation of secretionGO:00510461940.012
zymogen activationGO:0031638700.012
response to bacteriumGO:00096171440.012
positive regulation of cysteine type endopeptidase activityGO:2001056790.012
regulation of protein catabolic processGO:00421761550.012
reactive nitrogen species metabolic processGO:200105730.012
cell cycle g1 s phase transitionGO:0044843800.012
negative regulation of developmental processGO:00510932470.012
neuroblast proliferationGO:000740540.012
regulation of dna metabolic processGO:00510521530.012
head developmentGO:00603221080.012
blastoderm segmentationGO:000735020.012
organonitrogen compound biosynthetic processGO:19015662000.012
atp metabolic processGO:00460341760.012
response to cytokineGO:00340972320.012
cellular response to endogenous stimulusGO:00714953360.012
t cell differentiation in thymusGO:003307740.012
nucleoside monophosphate catabolic processGO:00091251590.012
central nervous system developmentGO:00074171230.012
regulation of anatomical structure morphogenesisGO:00226032860.012
cellular response to lipidGO:00713961270.012
regulation of cell cycle g1 s phase transitionGO:1902806420.012
response to radiationGO:00093141510.012
brain developmentGO:0007420970.012
inorganic ion transmembrane transportGO:00986602310.012
regulation of reactive oxygen species biosynthetic processGO:190342630.012
regulation of protein serine threonine kinase activityGO:00719001790.012
tissue regenerationGO:004224630.012
thymus developmentGO:004853830.012
regulation of mitotic cell cycle phase transitionGO:19019901180.012
atp catabolic processGO:00062001570.012
response to virusGO:00096151260.012
wnt signaling pathwayGO:00160551560.012
positive regulation of immune system processGO:00026842830.012
organic acid biosynthetic processGO:0016053970.012
immune system developmentGO:00025201950.012
regulation of ras protein signal transductionGO:00465781550.012
mitochondrial transportGO:0006839600.012
positive regulation of endopeptidase activityGO:0010950840.012
regulation of establishment of protein localizationGO:00702012420.012
developmental programmed cell deathGO:001062330.012
cellular homeostasisGO:00197251960.012
regulation of cell motilityGO:20001452990.011
negative regulation of transferase activityGO:00513481240.011
positive regulation of protein complex assemblyGO:0031334860.011
myoblast fusionGO:000752010.011
regulation of secretion by cellGO:19035301770.011
limbic system developmentGO:002176130.011
metencephalon developmentGO:002203720.011
lymphocyte activationGO:00466491330.011
negative regulation of protein phosphorylationGO:00019331400.011
associative learningGO:000830610.011
neural tube formationGO:000184130.011
negative regulation of protein processingGO:00109551420.011
response to axon injuryGO:004867810.011
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.011
cellular chemical homeostasisGO:00550821800.011
mitochondrial membrane organizationGO:0007006400.011
negative regulation of transportGO:00510511760.011
regulation of innate immune responseGO:0045088970.011
negative regulation of cell differentiationGO:00455961710.011
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.011
lipid catabolic processGO:0016042840.011
inorganic cation transmembrane transportGO:00986621940.011
multi organism cellular processGO:00447641560.011
regulation of transmembrane transportGO:00347621390.011
meiotic chromosome segregationGO:004513240.011
translationGO:00064121320.011
mitotic nuclear divisionGO:00070671190.011
response to fungusGO:000962040.011
lipid modificationGO:0030258840.011
enzyme linked receptor protein signaling pathwayGO:00071673030.011
purine ribonucleoside monophosphate metabolic processGO:00091671860.011
response to inorganic substanceGO:00100351270.011
regulation of reactive oxygen species metabolic processGO:2000377410.011
regulation of cellular component movementGO:00512703340.011
regulation of cell migrationGO:00303342890.011
regulation of cytoskeleton organizationGO:00514931770.011
regulation of cell activationGO:00508651250.011
anterior posterior axis specificationGO:000994820.011
regulation of cell growthGO:00015581350.011
release of cytoplasmic sequestered nf kappabGO:000858840.011
regulation of defense responseGO:00313471540.011
regulation of ras gtpase activityGO:00323181280.011
dna repairGO:00062811980.011
establishment of protein localization to mitochondrionGO:0072655220.011
ribonucleoside monophosphate metabolic processGO:00091611870.011
regulation of cell developmentGO:00602841610.011
negative regulation of apoptotic processGO:00430663160.011
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.011
cell fate determinationGO:000170930.011
chromosome segregationGO:00070591140.011
response to growth factorGO:00708482050.011
embryonic epithelial tube formationGO:000183840.011
protein targeting to mitochondrionGO:0006626190.011
cerebellum developmentGO:002154920.011
positive regulation of cell differentiationGO:00455972110.011
positive regulation of peptidase activityGO:0010952880.011
chromatin organizationGO:00063253510.011
cellular response to nitrogen compoundGO:19016991440.011
cell part morphogenesisGO:00329901370.010
nitrogen compound transportGO:00717051910.010
regulation of sequence specific dna binding transcription factor activityGO:00510902110.010
negative regulation of cell cycle processGO:00109481210.010
positive regulation of cytokine productionGO:00018191670.010
positive regulation of mapk cascadeGO:00434101900.010
peptidyl lysine modificationGO:00182051440.010
protein dephosphorylationGO:0006470810.010
cardiac muscle cell contractionGO:008600340.010
small molecule biosynthetic processGO:00442831570.010
purine ribonucleoside monophosphate catabolic processGO:00091691580.010
cell divisionGO:00513011680.010
negative regulation of apoptotic signaling pathwayGO:2001234970.010
ribonucleoside monophosphate catabolic processGO:00091581580.010
anatomical structure formation involved in morphogenesisGO:00486462840.010
cellular lipid catabolic processGO:0044242650.010
tripartite regional subdivisionGO:000735120.010
regulation of vesicle mediated transportGO:00606271300.010
protein localization to plasma membraneGO:0072659930.010
regulation of protein transportGO:00512232130.010
negative regulation of catabolic processGO:00098951040.010
cardiovascular system developmentGO:00723582620.010
peptidyl serine phosphorylationGO:00181051010.010
positive regulation of ras gtpase activityGO:00323201170.010
epithelium developmentGO:00604292270.010
methylationGO:00322591060.010
purine nucleoside monophosphate catabolic processGO:00091281580.010

PLEKHM1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.031
inherited metabolic disorderDOID:6552420.031
nervous system diseaseDOID:8634310.020
sensory system diseaseDOID:00501552030.020
eye diseaseDOID:56141490.017
eye and adnexa diseaseDOID:14921500.017
musculoskeletal system diseaseDOID:172230.014
central nervous system diseaseDOID:3311860.013
immune system diseaseDOID:29141550.012
connective tissue diseaseDOID:651090.012
organ system cancerDOID:00506861640.012
disease of cellular proliferationDOID:145661740.012
cancerDOID:1621670.012
retinal diseaseDOID:56791180.011
bone diseaseDOID:0080001880.011
retinal degenerationDOID:8466890.010
bone remodeling diseaseDOID:0080005260.004
osteosclerosisDOID:4254160.002
osteopetrosisDOID:1353390.002