Homo sapiens

79 known processes

ITCH

itchy E3 ubiquitin protein ligase homolog (mouse)

(Aliases: AIF4,AIP4,NAPP1,dJ468O1.1)

ITCH biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
phospholipid translocationGO:004533220.999
protein ubiquitinationGO:00165673140.998
protein modification by small protein conjugationGO:00324463420.996
protein catabolic processGO:00301633250.996
regulation of protein localizationGO:00328802960.994
Human Yeast Fly
modification dependent macromolecule catabolic processGO:00436322120.991
endosomal transportGO:00161971290.984
Yeast
negative regulation of protein localization to cell surfaceGO:200000950.983
Human
early endosome to golgi transportGO:003449830.983
regulation of protein oligomerizationGO:0032459260.980
lipid translocationGO:003420420.979
cellular ketone metabolic processGO:0042180800.975
Yeast
oxidative stress induced premature senescenceGO:009040330.971
positive regulation of developmental processGO:00510943140.970
Mouse
enzyme linked receptor protein signaling pathwayGO:00071673030.968
Human
modification dependent protein catabolic processGO:00199412090.965
positive regulation of protein oligomerizationGO:0032461170.963
chromatin assembly or disassemblyGO:0006333780.957
Yeast
regulation of protein kinase activityGO:00458592890.949
regulation of transferase activityGO:00513383550.947
positive regulation of phosphatidylinositol 3 kinase signalingGO:0014068280.947
Human
protein monoubiquitinationGO:0006513390.943
Yeast
negative regulation of apoptotic processGO:00430663160.943
response to growth factorGO:00708482050.942
Human
cellular response to transforming growth factor beta stimulusGO:0071560940.939
Human
macropinocytosisGO:004435110.937
ubiquitin dependent protein catabolic processGO:00065112060.934
negative regulation of multicellular organismal processGO:00512413170.929
response to abiotic stimulusGO:00096283360.928
Human Yeast
regulation of transcription from rna polymerase ii promoter in response to stressGO:0043618170.917
Human
cell developmentGO:00484683280.914
Human Worm
chromatin organizationGO:00063253510.909
Yeast
regulation of dna templated transcription in response to stressGO:0043620180.907
Human
negative regulation of cell deathGO:00605483450.893
cellular response to oxidative stressGO:0034599850.892
endosome organizationGO:0007032200.891
determination of adult lifespanGO:000834020.889
Worm
positive regulation of transferase activityGO:00513472270.885
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.883
cell divisionGO:00513011680.873
lipid localizationGO:00108761060.868
Worm Fly
transforming growth factor beta receptor signaling pathwayGO:0007179760.834
Human
intracellular protein transportGO:00068862700.834
Human
regulation of vesicle mediated transportGO:00606271300.830
Yeast
positive regulation of catabolic processGO:00098963100.830
Human Yeast Mouse
regulation of cytoskeleton organizationGO:00514931770.825
Yeast
protein localization to cell surfaceGO:0034394280.822
Human
positive regulation of protein complex assemblyGO:0031334860.817
cellular macromolecule catabolic processGO:00442653800.817
response to biotic stimulusGO:00096072760.807
glycerolipid metabolic processGO:00464861070.794
protein oligomerizationGO:00512591730.772
anion transportGO:00068201610.769
lipid metabolic processGO:00066293810.756
Yeast
positive regulation of protein kinase activityGO:00458601900.755
regulation of cellular component biogenesisGO:00440872810.753
Yeast
regulation of phosphatidylinositol 3 kinase signalingGO:0014066350.749
Human
negative regulation of leukocyte activationGO:0002695260.746
Mouse
lipid biosynthetic processGO:00086101770.743
Yeast
histone monoubiquitinationGO:0010390200.738
protein polyubiquitinationGO:00002091100.731
organophosphate catabolic processGO:00464344300.729
regulation of epithelial cell migrationGO:0010632930.727
regulation of protein complex assemblyGO:00432541470.719
negative regulation of protein serine threonine kinase activityGO:0071901570.718
positive regulation of protein phosphorylationGO:00019343130.716
cellular protein catabolic processGO:00442572610.711
regulation of proteolysisGO:00301622930.706
Yeast
negative regulation of sodium ion transmembrane transportGO:190230620.702
Human
neurogenesisGO:00220081690.701
Human Worm
actin cytoskeleton organizationGO:00300362070.698
Yeast
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.694
Human
negative regulation of cellular response to growth factor stimulusGO:0090288410.687
Human
regulation of protein serine threonine kinase activityGO:00719001790.684
negative regulation of transportGO:00510511760.677
Human
regulation of kinase activityGO:00435493140.671
ribonucleoside catabolic processGO:00424544060.663
negative regulation of protein metabolic processGO:00512483910.658
positive regulation of protein localization to cell surfaceGO:200001060.657
cellular macromolecular complex assemblyGO:00346223240.656
cellular amino acid metabolic processGO:00065201160.652
inositol lipid mediated signalingGO:0048017550.648
Human
nervous system developmentGO:00073992930.647
Human Worm
dna repairGO:00062811980.641
protein k48 linked ubiquitinationGO:0070936380.628
cofactor metabolic processGO:0051186870.626
Yeast
retrograde transport endosome to golgiGO:0042147450.611
post embryonic developmentGO:000979120.602
Fly
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101450.601
Human
phosphatidylinositol 3 kinase signalingGO:0014065480.599
Human
cellular response to growth factor stimulusGO:00713631970.597
Human
positive regulation of cellular component biogenesisGO:00440891580.597
proteolysis involved in cellular protein catabolic processGO:00516032440.597
generation of neuronsGO:00486991520.595
Human Worm
leukocyte activationGO:00453211640.592
Mouse
vesicle mediated transportGO:00161923710.590
Human Yeast Fly
positive regulation of protein catabolic processGO:0045732750.588
Human Yeast Mouse
regulation of protein catabolic processGO:00421761550.585
Human Yeast Mouse Worm
negative regulation of developmental processGO:00510932470.581
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathwayGO:003562540.581
negative regulation of jun kinase activityGO:004350840.578
regulation of receptor mediated endocytosisGO:0048259320.570
Yeast
response to external biotic stimulusGO:00432072610.566
gtp catabolic processGO:00061842370.561
ribonucleotide catabolic processGO:00092614050.559
activation of protein kinase activityGO:0032147900.554
negative regulation of ion transportGO:0043271390.544
Human
mapk cascadeGO:00001652880.544
Mouse
positive regulation of phosphorylationGO:00423273940.534
cellular lipid metabolic processGO:00442553030.529
Yeast
coenzyme metabolic processGO:0006732650.527
Yeast
positive regulation of kinase activityGO:00336742040.526
regulation of cell differentiationGO:00455953930.518
regulation of response to osmotic stressGO:004748430.512
cellular response to endogenous stimulusGO:00714953360.506
Human
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.499
Yeast
regulation of ion transportGO:00432691890.497
Human
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediatorGO:190225520.485
positive regulation of mapk cascadeGO:00434101900.472
cell agingGO:0007569520.469
negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:2001240160.467
negative regulation of map kinase activityGO:0043407270.463
regulation of actin cytoskeleton organizationGO:00329561160.460
Yeast
regulation of ossificationGO:0030278580.458
polyprenol biosynthetic processGO:001609410.457
Yeast
regulation of apoptotic signaling pathwayGO:20012331750.457
regulation of cellular ketone metabolic processGO:0010565500.454
Yeast
protein deubiquitinationGO:0016579790.453
Mouse
receptor internalizationGO:0031623430.452
Human Fly
membrane protein proteolysisGO:0033619380.446
regulation of endocytosisGO:0030100720.432
Yeast
carbohydrate metabolic processGO:00059752070.428
amine metabolic processGO:0009308440.425
negative regulation of cell differentiationGO:00455961710.420
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.416
phosphatidylinositol mediated signalingGO:0048015550.414
Human
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.412
Yeast
positive regulation of osteoblast differentiationGO:0045669230.407
purine ribonucleoside catabolic processGO:00461303980.407
single organism membrane organizationGO:00448022680.405
membrane tubulationGO:0097320120.403
actin filament based processGO:00300292240.401
Yeast
stress activated protein kinase signaling cascadeGO:0031098940.400
Mouse
regulation of endosome sizeGO:005103630.396
Yeast
negative regulation of sodium ion transportGO:001076630.390
Human
regulation of nucleotide catabolic processGO:00308112050.387
protein importGO:00170381300.381
nucleoside catabolic processGO:00091644080.379
regulation of mrna export from nucleusGO:001079330.378
Yeast
regulation of map kinase activityGO:00434051080.378
ubiquitin dependent endocytosisGO:007008610.376
Yeast
nucleoside triphosphate catabolic processGO:00091433940.374
cellular response to dna damage stimulusGO:00069743790.371
sphingolipid metabolic processGO:0006665380.367
regulation of membrane lipid distributionGO:009703590.367
positive regulation of purine nucleotide metabolic processGO:19005442270.361
cytoplasmic transportGO:00164823790.357
Human Yeast
positive regulation of cellular component organizationGO:00511303760.356
Yeast
positive regulation of cell differentiationGO:00455972110.354
cellular response to hypoxiaGO:0071456510.352
positive regulation of proteolysisGO:00458621420.351
Yeast
carboxylic acid biosynthetic processGO:0046394970.343
Yeast
cytoskeleton dependent cytokinesisGO:0061640220.339
multicellular organismal agingGO:001025930.338
Worm
cellular response to radiationGO:0071478650.337
Human Yeast
organic anion transportGO:00157111030.336
response to oxidative stressGO:00069791210.333
fatty acid biosynthetic processGO:0006633460.333
Yeast
positive regulation of transportGO:00510503360.333
Human Yeast
mitochondrion organizationGO:00070051560.330
Yeast
dissemination or transmission of symbiont from hostGO:004400710.328
Human
mitotic cell cycle processGO:19030472860.327
negative regulation of phosphorus metabolic processGO:00105632670.324
Mouse
regulation of protein localization to cell surfaceGO:2000008150.322
Human
membrane organizationGO:00610242920.320
positive regulation of locomotionGO:00400171860.318
negative regulation of programmed cell deathGO:00430693210.317
coenzyme biosynthetic processGO:0009108240.316
Yeast
ncrna metabolic processGO:00346601080.312
Yeast
ribosomal large subunit export from nucleusGO:000005530.311
Yeast
purine nucleoside triphosphate metabolic processGO:00091444120.310
ribonucleoside triphosphate catabolic processGO:00092033910.309
gtp metabolic processGO:00460392390.309
regulation of proteasomal protein catabolic processGO:0061136870.309
Yeast
lymphocyte activationGO:00466491330.300
Mouse
guanosine containing compound catabolic processGO:19010692390.296
purine containing compound catabolic processGO:00725234110.289
peptidyl tyrosine modificationGO:00182121700.286
regulation of leukocyte activationGO:00026941150.285
Mouse
nuclear transportGO:00511691790.281
Human Yeast
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.279
organelle localizationGO:0051640840.277
Yeast
positive regulation of gtp catabolic processGO:00331261660.277
regulation of notch signaling pathwayGO:0008593180.276
Fly
positive regulation of cell cycleGO:00457871400.276
rrna containing ribonucleoprotein complex export from nucleusGO:007142840.276
Yeast
regulation of cell motilityGO:20001452990.274
regulation of t cell activationGO:0050863770.274
Mouse
regulation of gtp catabolic processGO:00331241800.268
protein targetingGO:00066051870.267
Human
purine nucleotide catabolic processGO:00061954050.266
growthGO:00400072020.265
regulation of defense responseGO:00313471540.258
immune responseGO:00069553070.253
extrinsic apoptotic signaling pathwayGO:00971911190.252
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.248
Human Yeast
endocytosisGO:00068971590.247
Human Yeast Fly
regulation of jnk cascadeGO:0046328730.244
Mouse
glycerophospholipid metabolic processGO:0006650840.242
protein autophosphorylationGO:00467771230.240
spermatid developmentGO:000728640.239
protein modification by small protein removalGO:0070646920.239
Mouse
positive regulation of nucleoside metabolic processGO:00459791860.237
response to other organismGO:00517072610.236
negative regulation of lipid transportGO:0032369180.229
eye photoreceptor cell differentiationGO:000175420.229
purine ribonucleotide catabolic processGO:00091544040.225
negative regulation of cellular component organizationGO:00511292350.224
negative regulation of cellular protein metabolic processGO:00322693530.223
response to oxygen levelsGO:00704821000.222
small molecule biosynthetic processGO:00442831570.222
Yeast
regulation of anatomical structure sizeGO:00900661010.221
Yeast
regulation of lipid biosynthetic processGO:0046890470.220
Yeast
negative regulation of protein modification processGO:00314002000.219
purine nucleoside triphosphate catabolic processGO:00091463920.219
proteasomal protein catabolic processGO:00104981760.219
Human Yeast
regulation of nucleotide metabolic processGO:00061402690.218
establishment of protein localization to organelleGO:00725941720.218
Human
epithelium migrationGO:00901321190.217
mitotic cell cycleGO:00002783260.217
positive regulation of immune system processGO:00026842830.216
Mouse
positive regulation of gtpase activityGO:00435471660.215
regulation of protein tyrosine kinase activityGO:0061097360.215
golgi vesicle transportGO:0048193800.215
positive regulation of hydrolase activityGO:00513453310.211
ribonucleoside triphosphate metabolic processGO:00091994120.211
lipid tube assemblyGO:006098820.211
protein lipid complex assemblyGO:0065005120.209
negative regulation of kinase activityGO:00336731060.208
negative regulation of neuron differentiationGO:0045665210.206
cleavage furrow formationGO:003608950.206
development involved in symbiotic interactionGO:004411110.205
Human
phospholipid metabolic processGO:0006644990.204
negative regulation of protein phosphorylationGO:00019331400.204
purine ribonucleoside triphosphate metabolic processGO:00092054110.203
membrane protein ectodomain proteolysisGO:0006509330.202
regulation of gtpase activityGO:00430871800.200
single organism cell adhesionGO:00986021790.198
signal transduction by phosphorylationGO:00230142970.198
Mouse
negative regulation of transcription from rna polymerase ii promoter in response to uv induced dna damageGO:001076810.198
Human
positive regulation of cell motilityGO:20001471770.195
response to hypoxiaGO:0001666960.194
positive regulation of apoptotic signaling pathwayGO:2001235700.193
ribonucleoprotein complex biogenesisGO:00226131160.191
Yeast
mitotic cytokinesisGO:0000281190.190
defense responseGO:00069523150.189
muscle cell proliferationGO:0033002350.188
hippocampus developmentGO:002176610.188
positive regulation of mitochondrion organizationGO:0010822300.187
defense response to bacteriumGO:0042742630.187
cellular amine metabolic processGO:0044106410.187
positive regulation of nucleotide catabolic processGO:00308131850.187
negative regulation of cellular amine metabolic processGO:003323930.187
negative regulation of cardiac muscle cell proliferationGO:006004420.185
negative regulation of phospholipid transportGO:200113910.185
trna transportGO:005103110.184
Yeast
membrane lipid metabolic processGO:0006643530.183
activation of mapk activityGO:0000187450.180
regulation of potassium ion transportGO:0043266240.179
Human
regulation of cell migrationGO:00303342890.179
negative regulation of lipid biosynthetic processGO:0051055220.177
negative regulation of intracellular signal transductionGO:19025321830.177
Mouse
regulation of locomotionGO:00400123290.176
response to radiationGO:00093141510.175
Human Yeast
establishment of organelle localizationGO:0051656590.173
Yeast
oxidoreduction coenzyme metabolic processGO:0006733190.172
Yeast
cell activationGO:00017752130.171
Mouse
dolichol biosynthetic processGO:001940810.171
Yeast
positive regulation of reactive oxygen species metabolic processGO:2000379240.168
regulation of cellular protein catabolic processGO:1903362960.167
Yeast
transcription from rna polymerase iii promoterGO:0006383190.163
late endosome to vacuole transportGO:004532420.163
Yeast
nucleoside triphosphate metabolic processGO:00091414220.162
regulation of cell activationGO:00508651250.161
Mouse
secretionGO:00469032540.160
intrinsic apoptotic signaling pathwayGO:00971931270.160
regulation of homeostatic processGO:00328441210.160
Human
synaptic vesicle endocytosisGO:004848820.159
phospholipid transportGO:0015914230.158
regulation of ribosome biogenesisGO:009006910.158
Yeast
purine ribonucleoside triphosphate catabolic processGO:00092073910.157
positive regulation of membrane protein ectodomain proteolysisGO:0051044130.157
chromatin modificationGO:00165682980.157
negative regulation of catalytic activityGO:00430863350.156
maintenance of cell polarityGO:003001120.155
hepatocyte growth factor receptor signaling pathwayGO:004801280.154
cellular response to abiotic stimulusGO:00712141170.153
Human Yeast
regulation of protein transportGO:00512232130.151
Human
positive regulation of fibroblast apoptotic processGO:200027160.151
histone modificationGO:00165702510.147
peptidyl serine modificationGO:00182091060.145
positive regulation of cellular amino acid metabolic processGO:004576430.144
regulation of protein ubiquitinationGO:0031396950.143
regulation of purine nucleotide catabolic processGO:00331212050.142
organonitrogen compound biosynthetic processGO:19015662000.142
covalent chromatin modificationGO:00165692540.141
immune response activating signal transductionGO:0002757900.139
regulation of response to external stimulusGO:00321012220.136
glycosyl compound catabolic processGO:19016584130.135
maintenance of locationGO:00512351120.135
Worm Fly
wnt signaling pathwayGO:00160551560.134
regionalizationGO:0003002290.134
Fly
regulation of mapk cascadeGO:00434082620.133
Mouse
positive regulation of endothelial cell migrationGO:0010595390.133
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:0042787370.130
Human Yeast Mouse
trna processingGO:0008033230.128
Yeast
cellular response to nutrient levelsGO:0031669690.127
positive regulation of ion transportGO:0043270870.127
regulation of cellular component sizeGO:0032535820.127
Yeast
regulation of transcription from rna polymerase iii promoterGO:0006359130.126
stress activated mapk cascadeGO:0051403930.125
Mouse
muscle structure developmentGO:0061061980.123
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:2001239200.121
regulation of intracellular transportGO:00323861950.120
Human Yeast
regulation of actin filament based processGO:00329701410.120
Yeast
positive regulation of cell migrationGO:00303351720.120
regulation of purine nucleotide metabolic processGO:19005422640.119
quinone metabolic processGO:1901661180.118
Yeast
apoptotic signaling pathwayGO:00971902680.118
response to transforming growth factor betaGO:0071559940.118
Human
negative regulation of immune system processGO:00026831360.117
neuron differentiationGO:00301821380.116
Human Worm
negative regulation of response to external stimulusGO:0032102830.115
notch signaling pathwayGO:0007219310.115
Fly
purine nucleoside catabolic processGO:00061523980.114
chemical homeostasisGO:00488783060.112
Human
regulation of cell cycleGO:00517263930.112
intracellular receptor signaling pathwayGO:00305221040.111
Human
regulation of ketone biosynthetic processGO:001056670.111
Yeast
positive regulation of cell deathGO:00109422630.110
single organism cellular localizationGO:19025803320.110
Human
isoprenoid metabolic processGO:0006720390.109
Yeast
protein k63 linked ubiquitinationGO:0070534310.107
regulation of reactive oxygen species metabolic processGO:2000377410.107
membrane lipid biosynthetic processGO:0046467270.107
dna damage response signal transduction by p53 class mediatorGO:0030330440.107
response to ionizing radiationGO:0010212650.106
trna export from nucleusGO:000640910.106
Yeast
signal transduction in response to dna damageGO:0042770570.105
pattern specification processGO:0007389430.104
Fly
biological adhesionGO:00226103310.104
cytokinesisGO:0000910960.103
ubiquitin dependent smad protein catabolic processGO:003057940.102
Human
positive regulation of protein serine threonine kinase activityGO:00719021190.101
receptor mediated endocytosisGO:0006898840.099
Human Yeast Fly
chronological cell agingGO:000130020.099
regulation of cellular amine metabolic processGO:0033238110.099
establishment of ribosome localizationGO:003375340.098
Yeast
negative regulation of protein kinase activityGO:0006469980.097
regulation of cell developmentGO:00602841610.096
regulation of cardiac muscle cell proliferationGO:006004340.095
guanosine containing compound metabolic processGO:19010682440.094
negative regulation of endocytosisGO:0045806190.094
cell chemotaxisGO:00603261120.094
regulation of cellular response to stressGO:00801352440.094
Mouse
regulation of cellular component movementGO:00512703340.093
pinocytosisGO:000690780.091
glial cell differentiationGO:0010001110.091
negative regulation of cellular amino acid metabolic processGO:004576320.091
peptidyl serine phosphorylationGO:00181051010.091
cell adhesionGO:00071553250.090
regulation of nucleoside metabolic processGO:00091182090.090
regulation of rrna processingGO:200023210.089
Yeast
hemopoiesisGO:00300971800.088
negative regulation of apoptotic signaling pathwayGO:2001234970.088
regulation of cardiac muscle tissue growthGO:005502140.087
cellular response to external stimulusGO:00714961110.087
epithelial cell migrationGO:00106311190.086
regulation of establishment of protein localizationGO:00702012420.086
Human
histone ubiquitinationGO:0016574310.085
regulation of osteoblast differentiationGO:0045667380.085
negative regulation of protein transportGO:0051224750.084
Human
negative regulation of hormone metabolic processGO:003235160.084
negative regulation of lymphocyte differentiationGO:004562070.083
regulation of cellular response to growth factor stimulusGO:0090287760.083
Human
single organismal cell cell adhesionGO:00163371480.082
regulation of lipid metabolic processGO:0019216960.082
Yeast
response to bacteriumGO:00096171440.081
purine ribonucleoside metabolic processGO:00461284370.080
negative regulation of leukocyte differentiationGO:1902106240.079
endosome transport via multivesicular body sorting pathwayGO:003250930.078
Yeast
cellular response to decreased oxygen levelsGO:0036294510.078
lipid transportGO:0006869900.078
response to decreased oxygen levelsGO:0036293960.078
regulation of endothelial cell migrationGO:0010594670.078
negative regulation of t cell activationGO:0050868180.077
Mouse
autophagyGO:0006914880.077
Yeast
receptor transactivationGO:003562440.077
hematopoietic or lymphoid organ developmentGO:00485341860.076
regulation of mitochondrion organizationGO:0010821540.076
cofactor biosynthetic processGO:0051188310.076
Yeast
nucleoside phosphate catabolic processGO:19012924120.075
chromatin assemblyGO:0031497610.075
neuron developmentGO:00486661130.074
Human Worm
positive regulation of epithelial cell migrationGO:0010634550.074
positive regulation of cytoplasmic transportGO:1903651820.074
Human
positive regulation of neurogenesisGO:0050769490.073
photoreceptor cell differentiationGO:004653020.073
negative regulation of epidermal growth factor activated receptor activityGO:000717560.073
peptidyl tyrosine phosphorylationGO:00181081700.072
regulation of sequence specific dna binding transcription factor activityGO:00510902110.071
Mouse
positive regulation of organelle organizationGO:00106381950.071
striated muscle cell proliferationGO:001485570.070
regulation of epidermal growth factor activated receptor activityGO:0007176140.070
receptor metabolic processGO:0043112810.070
Human Fly
regulation of leukocyte differentiationGO:1902105610.069
regulation of isoprenoid metabolic processGO:001974710.069
Yeast
spermatid differentiationGO:004851540.069
positive regulation of cell sizeGO:004579330.069
cellular response to fibroblast growth factor stimulusGO:0044344390.068
positive regulation of cell proliferationGO:00082843010.067
regulation of sphingolipid biosynthetic processGO:009015320.066
regulation of hormone metabolic processGO:0032350140.066
negative regulation of striated muscle tissue developmentGO:0045843110.066
fibroblast apoptotic processGO:004434680.066
positive regulation of immune responseGO:00507781590.065
ribonucleoprotein complex localizationGO:007116640.065
Yeast
secretion by cellGO:00329402260.065
regulation of transcription from rna polymerase ii promoter in response to uv induced dna damageGO:001076710.065
Human
positive regulation of phospholipid transportGO:200114040.064
ribosomal subunit export from nucleusGO:000005440.064
Yeast
immune system developmentGO:00025201950.064
Mouse
cellular response to biotic stimulusGO:0071216710.064
regulation of cofactor metabolic processGO:005119330.063
Yeast
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathwayGO:0043162100.063
Human Yeast
nitrogen compound transportGO:00717051910.063
Yeast
organ morphogenesisGO:00098871470.062
Fly
immune response regulating cell surface receptor signaling pathwayGO:0002768510.062
nucleotide excision repairGO:0006289310.062
hormone biosynthetic processGO:0042446220.062
regulation of microtubule cytoskeleton organizationGO:0070507610.061
response to endoplasmic reticulum stressGO:0034976490.061
nucleotide catabolic processGO:00091664080.061
defense response to other organismGO:00985421290.061
reactive oxygen species metabolic processGO:0072593750.061
positive regulation of map kinase activityGO:0043406800.061
regulation of immune responseGO:00507762010.061
negative regulation of mapk cascadeGO:0043409560.060
Mouse
cellular component morphogenesisGO:00329893140.060
Yeast
striated muscle tissue developmentGO:0014706590.060
positive regulation of erk1 and erk2 cascadeGO:0070374750.060
notch receptor processingGO:000722020.059
organic hydroxy compound metabolic processGO:19016151470.059
Yeast
ncrna processingGO:0034470830.059
Yeast
cell projection organizationGO:00300302520.059
Human Yeast Worm
response to cytokineGO:00340972320.058
ribosome localizationGO:003375040.058
Yeast
regulation of neuron differentiationGO:0045664700.057
regulation of hormone biosynthetic processGO:0046885100.057
negative regulation of stress activated mapk cascadeGO:0032873190.057
Mouse
negative regulation of phosphate metabolic processGO:00459362670.056
Mouse
positive regulation of endocytosisGO:0045807420.056
Yeast
actin filament organizationGO:00070151280.056
positive regulation of stress activated protein kinase signaling cascadeGO:0070304610.055
polyprenol metabolic processGO:001609330.054
Yeast
regulation of potassium ion transmembrane transportGO:1901379200.054
Human
transmission of virusGO:001908910.054
Human
regulation of cellular amino acid metabolic processGO:000652160.053
signal transduction in absence of ligandGO:0038034220.053
negative regulation of defense responseGO:0031348470.053
negative regulation of peptidyl tyrosine phosphorylationGO:0050732200.053
regulation of protein import into nucleusGO:0042306780.053
response to drugGO:0042493810.052
Yeast
erk1 and erk2 cascadeGO:00703711040.051
regulation of erbb signaling pathwayGO:1901184270.051
epithelial cell differentiationGO:00308551410.051
protein maturationGO:00516042330.051
ossificationGO:00015031210.051
negative regulation of lipid metabolic processGO:0045833380.050
response to woundingGO:00096111680.050
multi organism reproductive processGO:0044703540.050
Yeast
cellular response to oxygen levelsGO:0071453550.050
regulation of coenzyme metabolic processGO:005119630.050
Yeast
response to uvGO:0009411730.049
Human Yeast
immune response activating cell surface receptor signaling pathwayGO:0002429450.049
ameboidal type cell migrationGO:00016671350.049

ITCH disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
sensory system diseaseDOID:00501552030.133
eye diseaseDOID:56141490.133
nervous system diseaseDOID:8634310.133
eye and adnexa diseaseDOID:14921500.133
cancerDOID:1621670.128
disease of cellular proliferationDOID:145661740.128
organ system cancerDOID:00506861640.128
neurodegenerative diseaseDOID:12891020.100
central nervous system diseaseDOID:3311860.100
retinal degenerationDOID:8466890.088
retinal diseaseDOID:56791180.088