Homo sapiens

142 known processes

LEO1

Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

(Aliases: RDL)

LEO1 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of transcription elongation from rna polymerase ii promoterGO:0032968101.000
positive regulation of dna templated transcription elongationGO:0032786181.000
mrna 3 end processingGO:0031124241.000
histone h2b ubiquitinationGO:003352381.000
regulation of dna templated transcription elongationGO:0032784230.996
negative regulation of myeloid cell differentiationGO:0045638420.994
transcription elongation from rna polymerase ii promoterGO:0006368180.992
rna 3 end processingGO:0031123350.990
regulation of transcription elongation from rna polymerase ii promoterGO:0034243130.990
transcription initiation from rna polymerase ii promoterGO:0006367270.983
positive regulation of mrna metabolic processGO:1903313190.981
regulation of myeloid cell differentiationGO:0045637810.973
rna processingGO:00063962550.962
mrna processingGO:00063971330.956
post embryonic developmentGO:000979120.954
Worm
endodermal cell fate commitmentGO:000171140.941
regulation of mrna 3 end processingGO:0031440120.929
mrna metabolic processGO:00160711750.916
cellular amino acid metabolic processGO:00065201160.907
chromatin organizationGO:00063253510.901
peptidyl lysine methylationGO:0018022370.889
myeloid cell differentiationGO:00300991170.885
nucleic acid phosphodiester bond hydrolysisGO:00903051020.882
phosphorylation of rna polymerase ii c terminal domainGO:007081630.870
positive regulation of mrna 3 end processingGO:0031442120.868
protein monoubiquitinationGO:0006513390.839
negative regulation of cell differentiationGO:00455961710.818
negative regulation of multicellular organismal processGO:00512413170.813
hematopoietic or lymphoid organ developmentGO:00485341860.800
endodermal cell differentiationGO:0035987310.798
protein ubiquitinationGO:00165673140.786
histone h3 k4 methylationGO:0051568270.761
histone monoubiquitinationGO:0010390200.757
chromatin modificationGO:00165682980.725
dna templated transcription elongationGO:0006354250.696
negative regulation of immune system processGO:00026831360.672
histone lysine methylationGO:0034968500.669
histone h3 k79 methylationGO:003472920.644
regulation of protein complex assemblyGO:00432541470.643
digestive tract morphogenesisGO:0048546560.619
regulation of cellular amine metabolic processGO:0033238110.594
histone ubiquitinationGO:0016574310.593
covalent chromatin modificationGO:00165692540.583
dna templated transcription terminationGO:000635330.582
growthGO:00400072020.565
Worm
ncrna processingGO:0034470830.558
blastocyst developmentGO:000182430.538
protein modification by small protein conjugationGO:00324463420.533
hemopoiesisGO:00300971800.522
positive regulation of chromatin modificationGO:1903310300.512
negative regulation of developmental processGO:00510932470.506
response to bacteriumGO:00096171440.497
positive regulation of cellular amino acid metabolic processGO:004576430.496
regulation of chromatin organizationGO:1902275560.496
formation of primary germ layerGO:0001704420.493
muscle system processGO:0003012810.492
positive regulation of cellular component organizationGO:00511303760.490
histone modificationGO:00165702510.482
regulation of cellular component biogenesisGO:00440872810.429
histone methylationGO:0016571600.419
regulation of cell differentiationGO:00455953930.417
cellular response to molecule of bacterial originGO:0071219620.413
peptidyl lysine trimethylationGO:0018023100.409
regulation of dna templated transcription initiationGO:200014290.400
response to lipopolysaccharideGO:0032496700.390
transcription from rna polymerase iii promoterGO:0006383190.389
cytokine mediated signaling pathwayGO:00192211090.379
endocytosisGO:00068971590.326
Worm
positive regulation of transcription initiation from rna polymerase ii promoterGO:006026140.322
protein complex disassemblyGO:0043241520.316
vesicle mediated transportGO:00161923710.312
Worm
gene silencingGO:0016458490.308
response to external biotic stimulusGO:00432072610.288
protein alkylationGO:0008213740.281
response to other organismGO:00517072610.279
cellular response to cytokine stimulusGO:00713451810.269
embryonic morphogenesisGO:0048598850.260
dna templated transcription initiationGO:0006352350.256
stem cell differentiationGO:0048863930.233
ncrna metabolic processGO:00346601080.229
trophectodermal cell differentiationGO:000182930.226
peptidyl lysine modificationGO:00182051440.222
positive regulation of chromosome organizationGO:2001252410.222
cellular amine metabolic processGO:0044106410.215
cellular response to oxygen containing compoundGO:19017012760.211
positive regulation of organelle organizationGO:00106381950.209
stem cell developmentGO:0048864690.207
tube developmentGO:00352951250.206
cellular response to lipopolysaccharideGO:0071222570.205
rna polyadenylationGO:0043631140.200
rna polymerase ii transcriptional preinitiation complex assemblyGO:005112340.197
stem cell maintenanceGO:0019827190.189
regulation of dna metabolic processGO:00510521530.188
positive regulation of histone modificationGO:0031058290.188
immune system developmentGO:00025201950.186
histone h3 k4 trimethylationGO:008018270.177
receptor mediated endocytosisGO:0006898840.174
Worm
erythrocyte differentiationGO:0030218280.171
cellular response to dna damage stimulusGO:00069743790.171
regulation of cellular amino acid metabolic processGO:000652160.170
anatomical structure formation involved in morphogenesisGO:00486462840.168
cellular response to interleukin 6GO:0071354140.168
response to biotic stimulusGO:00096072760.164
regulation of cell cycle processGO:00105642660.161
regulation of g1 s transition of mitotic cell cycleGO:2000045400.160
endoderm developmentGO:0007492330.160
regulation of cellular ketone metabolic processGO:0010565500.151
digestive tract developmentGO:0048565750.151
response to oxygen containing compoundGO:19017003690.146
amine metabolic processGO:0009308440.140
protein methylationGO:0006479740.138
cell cycle phase transitionGO:00447701730.138
regulation of protein ubiquitinationGO:0031396950.136
mrna polyadenylationGO:0006378120.135
positive regulation of protein complex assemblyGO:0031334860.131
cell fate commitmentGO:0045165270.130
cell fate commitment involved in formation of primary germ layerGO:006079560.122
cellular macromolecular complex assemblyGO:00346223240.121
mitotic cell cycle phase transitionGO:00447721620.116
negative regulation of cell cycle phase transitionGO:1901988890.109
ncrna 3 end processingGO:004362840.103
regulation of histone modificationGO:0031056470.096
muscle contractionGO:0006936730.095
digestive system developmentGO:0055123750.092
gastrulationGO:0007369510.089
cellular response to biotic stimulusGO:0071216710.089
regulation of cellular response to stressGO:00801352440.088
macromolecular complex disassemblyGO:0032984600.087
positive regulation of histone h3 k4 methylationGO:005157180.085
regulation of transcription by chromatin organizationGO:003440110.083
embryo developmentGO:00097901230.083
Worm
mitotic cell cycle processGO:19030472860.082
macromolecule methylationGO:0043414970.077
response to molecule of bacterial originGO:0002237820.076
regulation of chromosome organizationGO:00330441030.071
regulation of mrna processingGO:0050684480.070
genetic imprintingGO:007151410.067
cell developmentGO:00484683280.067
methylationGO:00322591060.066
protein dna complex assemblyGO:0065004640.066
endoderm formationGO:0001706330.062
embryo development ending in birth or egg hatchingGO:0009792340.062
Worm
negative regulation of cell cycleGO:00457861930.061
oogenesisGO:004847720.061
response to lipidGO:00339932060.060
ribonucleoside catabolic processGO:00424544060.059
regulation of chromatin silencingGO:003193580.056
nucleoside catabolic processGO:00091644080.053
female gamete generationGO:000729220.052
cell cycle g1 s phase transitionGO:0044843800.052
regulation of histone methylationGO:0031060160.051
g1 s transition of mitotic cell cycleGO:0000082780.050
nucleotide catabolic processGO:00091664080.050
negative regulation of cell cycle g1 s phase transitionGO:1902807290.049
snorna metabolic processGO:001607410.048
blastocyst formationGO:000182530.047
negative regulation of cell cycle processGO:00109481210.043
cellular ketone metabolic processGO:0042180800.043
response to cytokineGO:00340972320.042
regulation of response to dna damage stimulusGO:2001020940.039
positive regulation of cellular amine metabolic processGO:003324070.038
nucleoside phosphate catabolic processGO:19012924120.035
dephosphorylationGO:00163112090.034
negative regulation of gene expression epigeneticGO:0045814190.034
positive regulation of developmental processGO:00510943140.034
Worm
negative regulation of catalytic activityGO:00430863350.033
purine containing compound catabolic processGO:00725234110.033
reproductionGO:0000003630.033
Worm
jak stat cascadeGO:0007259460.031
positive regulation of cellular component biogenesisGO:00440891580.031
positive regulation of smoothened signaling pathwayGO:004588040.031
nervous system developmentGO:00073992930.031
purine nucleoside triphosphate metabolic processGO:00091444120.031
positive regulation of transcription from rna polymerase i promoterGO:004594360.031
guanosine containing compound catabolic processGO:19010692390.030
purine ribonucleoside catabolic processGO:00461303980.030
regulation of mitotic cell cycle phase transitionGO:19019901180.030
ribonucleoside triphosphate catabolic processGO:00092033910.029
development of primary sexual characteristicsGO:0045137350.028
Worm
erythrocyte homeostasisGO:0034101310.027
regulation of cell cycle g1 s phase transitionGO:1902806420.027
protein dna complex subunit organizationGO:0071824800.027
regulation of protein kinase activityGO:00458592890.027
transcription from rna polymerase i promoterGO:0006360110.027
positive regulation of cell proliferationGO:00082843010.026
multicellular organismal agingGO:001025930.025
regulation of mitotic cell cycleGO:00073461890.025
regulation of proteolysisGO:00301622930.025
nucleoside triphosphate catabolic processGO:00091433940.025
regulation of wnt signaling pathwayGO:00301111230.025
chordate embryonic developmentGO:0043009340.024
internal protein amino acid acetylationGO:00064751010.024
positive regulation of histone methylationGO:0031062120.023
rna interferenceGO:001624640.022
cytoplasmic transportGO:00164823790.022
organophosphate catabolic processGO:00464344300.022
cellular response to lipidGO:00713961270.022
cellular macromolecule catabolic processGO:00442653800.022
posttranscriptional regulation of gene expressionGO:00106082130.022
gtp catabolic processGO:00061842370.022
negative regulation of protein metabolic processGO:00512483910.022
regulation of protein stabilityGO:0031647870.022
regulation of protein processingGO:00706131500.022
segmentationGO:003528240.021
regulation of gene silencingGO:0060968240.021
negative regulation of proteolysisGO:00458611320.021
protein processingGO:00164852260.021
purine nucleoside catabolic processGO:00061523980.021
regulation of transcription initiation from rna polymerase ii promoterGO:006026080.020
system processGO:00030083490.020
positive regulation of cellular catabolic processGO:00313312840.020
regulation of meiosisGO:004002030.020
response to interleukin 6GO:0070741150.019
microtubule based processGO:00070172100.019
determination of adult lifespanGO:000834020.019
dna repairGO:00062811980.019
cell growthGO:00160491600.019
oocyte developmentGO:004859910.018
cellular component disassemblyGO:0022411920.018
homeostasis of number of cellsGO:0048872400.018
purine nucleotide catabolic processGO:00061954050.018
purine ribonucleoside triphosphate catabolic processGO:00092073910.018
ribonucleoside triphosphate metabolic processGO:00091994120.018
negative regulation of cellular protein metabolic processGO:00322693530.018
regulation of rna polymerase ii transcriptional preinitiation complex assemblyGO:004589830.017
glycosyl compound catabolic processGO:19016584130.017
gtp metabolic processGO:00460392390.017
ribonucleoprotein complex biogenesisGO:00226131160.017
regulation of protein complex disassemblyGO:0043244280.017
oocyte differentiationGO:000999420.017
rna phosphodiester bond hydrolysisGO:0090501350.017
trna metabolic processGO:0006399350.017
reproductive processGO:00224141060.016
Worm
positive regulation of protein phosphorylationGO:00019343130.016
sex differentiationGO:0007548450.016
Worm
regenerationGO:003109940.016
tissue regenerationGO:004224630.015
protein catabolic processGO:00301633250.015
dna templated transcriptional preinitiation complex assemblyGO:007089750.015
posttranscriptional gene silencingGO:0016441250.015
regulation of epithelial cell proliferationGO:00506781130.015
reproductive system developmentGO:0061458560.015
Worm
wnt signaling pathwayGO:00160551560.015
viral processGO:00160321460.015
nucleoside triphosphate metabolic processGO:00091414220.015
interleukin 6 mediated signaling pathwayGO:007010270.015
regulation of mrna metabolic processGO:1903311530.015
positive regulation of hydrolase activityGO:00513453310.015
negative regulation of cellular component organizationGO:00511292350.015
negative regulation of protein processingGO:00109551420.015
positive regulation of wnt signaling pathwayGO:0030177540.014
actin filament based processGO:00300292240.014
negative regulation of phosphate metabolic processGO:00459362670.014
regulation of dephosphorylationGO:0035303960.014
brain morphogenesisGO:004885410.014
regulation of meiotic cell cycleGO:005144540.014
cellular protein complex assemblyGO:00436231880.014
nucleoside monophosphate catabolic processGO:00091251590.014
purine ribonucleotide catabolic processGO:00091544040.014
neuroendocrine cell differentiationGO:006110120.013
negative regulation of dephosphorylationGO:0035305630.013
organelle assemblyGO:00709251760.013
positive regulation of mrna processingGO:0050685170.013
ribonucleotide catabolic processGO:00092614050.013
anterior posterior axis specificationGO:000994820.013
response to hypoxiaGO:0001666960.013
purine ribonucleoside triphosphate metabolic processGO:00092054110.013
neuromuscular junction developmentGO:000752830.013
peripheral nervous system developmentGO:000742220.013
negative regulation of hydrolase activityGO:00513461820.013
guanosine containing compound metabolic processGO:19010682440.012
response to woundingGO:00096111680.012
negative regulation of protein modification processGO:00314002000.012
negative regulation of mitotic cell cycleGO:00459301020.012
protein destabilizationGO:0031648120.012
spindle organizationGO:0007051530.012
regulation of purine nucleotide metabolic processGO:19005422640.012
purine nucleoside triphosphate catabolic processGO:00091463920.012
blood vessel morphogenesisGO:00485141620.012
cell activationGO:00017752130.012
rrna metabolic processGO:0016072400.012
regulation of protein transportGO:00512232130.012
protein maturationGO:00516042330.012
regulation of cell morphogenesisGO:00226041530.012
negative regulation of programmed cell deathGO:00430693210.012
regulation of neurogenesisGO:0050767820.012
regulation of dna repairGO:0006282470.011
regulation of anatomical structure morphogenesisGO:00226032860.011
regulation of protein modification by small protein conjugation or removalGO:19033201070.011
positive regulation of programmed cell deathGO:00430682490.011
purine ribonucleoside metabolic processGO:00461284370.011
regulation of cell cycleGO:00517263930.011
regulation of growthGO:00400081650.011
Worm
cardiovascular system developmentGO:00723582620.011
negative regulation of phosphatase activityGO:0010923610.011
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.011
regulation of membrane potentialGO:0042391950.011
rna splicingGO:00083801310.011
myosin filament organizationGO:003103320.011
regulation of transferase activityGO:00513383550.010
viral life cycleGO:00190581320.010
regulation of cellular protein catabolic processGO:1903362960.010
negative regulation of intracellular signal transductionGO:19025321830.010
intrinsic apoptotic signaling pathwayGO:00971931270.010
protein targetingGO:00066051870.010
dna conformation changeGO:00711031130.010

LEO1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
organ system cancerDOID:00506861640.655
disease of cellular proliferationDOID:145661740.655
cancerDOID:1621670.655
endocrine gland cancerDOID:170260.655
endocrine system diseaseDOID:28260.016