Homo sapiens

0 known processes

DPEP3

dipeptidase 3

(Aliases: MBD3)

DPEP3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amino acid metabolic processGO:00065201160.183
Human
cellular amine metabolic processGO:0044106410.149
amine metabolic processGO:0009308440.145
regulation of cellular amine metabolic processGO:0033238110.133
cation transportGO:00068123310.125
regulation of cellular ketone metabolic processGO:0010565500.125
cellular ketone metabolic processGO:0042180800.123
metal ion transportGO:00300012720.121
regulation of cellular amino acid metabolic processGO:000652160.103
positive regulation of cellular amine metabolic processGO:003324070.101
regulation of ion transportGO:00432691890.097
negative regulation of cell deathGO:00605483450.096
Human
regulation of transferase activityGO:00513383550.089
negative regulation of apoptotic processGO:00430663160.088
Human
inorganic cation transmembrane transportGO:00986621940.084
ion homeostasisGO:00508012300.084
positive regulation of cellular amino acid metabolic processGO:004576430.082
positive regulation of transportGO:00510503360.082
system processGO:00030083490.081
chromatin organizationGO:00063253510.076
cellular ion homeostasisGO:00068731680.075
metal ion homeostasisGO:00550651690.075
positive regulation of protein phosphorylationGO:00019343130.074
response to abiotic stimulusGO:00096283360.069
negative regulation of programmed cell deathGO:00430693210.068
Human
chemical homeostasisGO:00488783060.066
ion transmembrane transportGO:00342203380.066
anatomical structure formation involved in morphogenesisGO:00486462840.063
post embryonic developmentGO:000979120.063
small gtpase mediated signal transductionGO:0007264780.063
positive regulation of protein kinase activityGO:00458601900.062
positive regulation of transferase activityGO:00513472270.062
circulatory system developmentGO:00723592620.059
positive regulation of phosphorylationGO:00423273940.059
inorganic ion transmembrane transportGO:00986602310.058
chromatin modificationGO:00165682980.058
regulation of locomotionGO:00400123290.057
Human
signal transduction by phosphorylationGO:00230142970.057
response to oxygen containing compoundGO:19017003690.056
cation homeostasisGO:00550801890.056
transmembrane transportGO:00550853990.056
nervous system developmentGO:00073992930.053
mapk cascadeGO:00001652880.051
regulation of protein kinase activityGO:00458592890.051
cation transmembrane transportGO:00986552380.050
negative regulation of transportGO:00510511760.049
neurological system processGO:00508771630.048
positive regulation of ion transportGO:0043270870.048
g protein coupled receptor signaling pathwayGO:00071862070.047
purine nucleoside catabolic processGO:00061523980.047
organophosphate catabolic processGO:00464344300.047
peptidyl tyrosine phosphorylationGO:00181081700.046
ribonucleoside triphosphate catabolic processGO:00092033910.046
negative regulation of cellular protein metabolic processGO:00322693530.046
Human
secretionGO:00469032540.045
regulation of kinase activityGO:00435493140.044
purine ribonucleoside metabolic processGO:00461284370.044
ribonucleoside triphosphate metabolic processGO:00091994120.043
purine ribonucleoside triphosphate metabolic processGO:00092054110.043
cellular response to dna damage stimulusGO:00069743790.043
regulation of secretion by cellGO:19035301770.043
monovalent inorganic cation transportGO:00156721280.042
cellular cation homeostasisGO:00300031630.042
nucleotide catabolic processGO:00091664080.041
purine ribonucleoside triphosphate catabolic processGO:00092073910.041
regulation of mapk cascadeGO:00434082620.041
regulation of cell motilityGO:20001452990.041
Human
central nervous system developmentGO:00074171230.040
nucleoside phosphate catabolic processGO:19012924120.040
ribonucleotide catabolic processGO:00092614050.039
purine nucleoside triphosphate catabolic processGO:00091463920.039
positive regulation of nucleotide metabolic processGO:00459812300.039
regulation of cellular component movementGO:00512703340.039
Human
positive regulation of cell motilityGO:20001471770.039
peptidyl tyrosine modificationGO:00182121700.039
activation of protein kinase activityGO:0032147900.039
purine nucleoside triphosphate metabolic processGO:00091444120.038
response to biotic stimulusGO:00096072760.038
purine containing compound catabolic processGO:00725234110.038
memoryGO:000761330.038
negative regulation of protein metabolic processGO:00512483910.038
Human
nucleoside triphosphate metabolic processGO:00091414220.037
cellular response to endogenous stimulusGO:00714953360.037
immune responseGO:00069553070.037
positive regulation of kinase activityGO:00336742040.037
cytoplasmic transportGO:00164823790.036
response to cytokineGO:00340972320.036
regulation of nucleotide metabolic processGO:00061402690.036
monocarboxylic acid metabolic processGO:00327871850.036
divalent inorganic cation transportGO:00725111580.036
cell projection organizationGO:00300302520.036
cellular divalent inorganic cation homeostasisGO:00725031280.035
cell developmentGO:00484683280.035
divalent metal ion transportGO:00708381520.035
regulation of cell migrationGO:00303342890.035
Human
cytosolic calcium ion homeostasisGO:0051480890.034
positive regulation of cell proliferationGO:00082843010.034
blood circulationGO:00080151130.034
growthGO:00400072020.034
glycosyl compound catabolic processGO:19016584130.034
regulation of peptidyl tyrosine phosphorylationGO:00507301080.033
purine nucleotide catabolic processGO:00061954050.033
calcium ion homeostasisGO:00550741220.033
response to other organismGO:00517072610.032
calcium ion transportGO:00068161470.032
regulation of purine nucleotide metabolic processGO:19005422640.032
regulation of secretionGO:00510461940.032
regulation of metal ion transportGO:00109591200.031
positive regulation of catabolic processGO:00098963100.031
cell activationGO:00017752130.031
cell cell signalingGO:00072671550.031
response to lipidGO:00339932060.030
nucleoside catabolic processGO:00091644080.030
positive regulation of developmental processGO:00510943140.030
response to external biotic stimulusGO:00432072610.029
female gamete generationGO:000729220.029
cardiovascular system developmentGO:00723582620.029
neuromuscular junction developmentGO:000752830.029
divalent inorganic cation homeostasisGO:00725071360.029
positive regulation of map kinase activityGO:0043406800.029
regulation of cell cycleGO:00517263930.029
regulation of cell differentiationGO:00455953930.028
response to organonitrogen compoundGO:00102431560.028
organonitrogen compound biosynthetic processGO:19015662000.028
positive regulation of cellular component organizationGO:00511303760.028
single organism cellular localizationGO:19025803320.028
positive regulation of purine nucleotide metabolic processGO:19005442270.028
cellular calcium ion homeostasisGO:00068741170.028
ras protein signal transductionGO:0007265730.028
nucleoside triphosphate catabolic processGO:00091433940.028
ribonucleoside catabolic processGO:00424544060.028
regulation of response to external stimulusGO:00321012220.027
regulation of protein serine threonine kinase activityGO:00719001790.027
determination of adult lifespanGO:000834020.027
adult locomotory behaviorGO:000834410.027
response to nitrogen compoundGO:19016981840.027
cellular homeostasisGO:00197251960.027
response to radiationGO:00093141510.027
apoptotic signaling pathwayGO:00971902680.027
purine ribonucleoside monophosphate metabolic processGO:00091671860.027
regulation of transmembrane transportGO:00347621390.026
actin mediated cell contractionGO:0070252120.026
multicellular organismal agingGO:001025930.026
muscle contractionGO:0006936730.026
histone modificationGO:00165702510.026
negative regulation of locomotionGO:00400131180.026
Human
matingGO:000761810.026
secretion by cellGO:00329402260.026
enzyme linked receptor protein signaling pathwayGO:00071673030.026
circulatory system processGO:00030131130.026
locomotory behaviorGO:000762610.026
small molecule biosynthetic processGO:00442831570.026
bud outgrowth involved in lung branchingGO:006044710.025
purine ribonucleoside catabolic processGO:00461303980.025
response to woundingGO:00096111680.025
response to organic cyclic compoundGO:00140702040.025
detection of stimulusGO:0051606850.025
negative regulation of cellular amine metabolic processGO:003323930.024
negative regulation of cellular amino acid metabolic processGO:004576320.024
cellular chemical homeostasisGO:00550821800.024
reactive oxygen species biosynthetic processGO:190340940.024
regulation of ion transmembrane transporter activityGO:0032412720.024
negative regulation of protein modification processGO:00314002000.024
defense responseGO:00069523150.024
positive regulation of hydrolase activityGO:00513453310.024
covalent chromatin modificationGO:00165692540.024
ribonucleoside monophosphate metabolic processGO:00091611870.024
cellular response to cytokine stimulusGO:00713451810.024
positive regulation of cellular catabolic processGO:00313312840.024
biological adhesionGO:00226103310.024
nucleoside monophosphate catabolic processGO:00091251590.023
negative regulation of catalytic activityGO:00430863350.023
Human
nucleoside monophosphate metabolic processGO:00091231910.023
regulation of cellular response to stressGO:00801352440.023
regulation of leukocyte activationGO:00026941150.023
cellular response to oxygen containing compoundGO:19017012760.023
oxidation reduction processGO:00551143960.023
purine nucleoside monophosphate catabolic processGO:00091281580.023
negative regulation of multicellular organismal processGO:00512413170.023
epithelial tube branching involved in lung morphogenesisGO:006044140.023
regulation of intracellular transportGO:00323861950.023
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.023
reactive oxygen species metabolic processGO:0072593750.022
positive regulation of protein serine threonine kinase activityGO:00719021190.022
vesicle mediated transportGO:00161923710.022
positive regulation of cellular component movementGO:00512721810.022
brain developmentGO:0007420970.022
positive regulation of mapk cascadeGO:00434101900.022
regulation of anatomical structure morphogenesisGO:00226032860.022
negative regulation of phosphorus metabolic processGO:00105632670.022
intracellular protein transportGO:00068862700.022
protein modification by small protein conjugationGO:00324463420.022
regulation of growthGO:00400081650.022
activation of mapk activityGO:0000187450.022
regulation of cytokine productionGO:00018172320.022
sensory perception of painGO:001923340.022
purine nucleoside monophosphate metabolic processGO:00091261860.022
cell morphogenesisGO:00009022960.021
cellular potassium ion transportGO:0071804600.021
regulation of ion transmembrane transportGO:00347651320.021
cellular lipid metabolic processGO:00442553030.021
atp metabolic processGO:00460341760.021
protein ubiquitinationGO:00165673140.021
regulation of calcium ion transportGO:0051924790.021
sensory perceptionGO:00076001030.021
cellular component morphogenesisGO:00329893140.021
positive regulation of cytosolic calcium ion concentrationGO:0007204820.021
mitotic cell cycleGO:00002783260.021
single organism membrane organizationGO:00448022680.021
positive regulation of cell migrationGO:00303351720.020
oogenesisGO:004847720.020
lung alveolus developmentGO:004828640.020
negative regulation of cell proliferationGO:00082852280.020
mitotic cell cycle processGO:19030472860.020
ribonucleoside monophosphate catabolic processGO:00091581580.020
cellular macromolecular complex assemblyGO:00346223240.020
sodium ion transmembrane transportGO:0035725590.020
response to inorganic substanceGO:00100351270.020
regulation of map kinase activityGO:00434051080.020
positive regulation of secretionGO:00510471160.020
regulation of cell cycle processGO:00105642660.020
cellular response to nitrogen compoundGO:19016991440.019
purine ribonucleotide catabolic processGO:00091544040.019
positive regulation of cell differentiationGO:00455972110.019
reproductive processGO:00224141060.019
epithelial cell migrationGO:00106311190.019
negative regulation of cell motilityGO:20001461040.019
Human
negative regulation of phosphate metabolic processGO:00459362670.019
regulation of nucleoside metabolic processGO:00091182090.019
erk1 and erk2 cascadeGO:00703711040.019
anion transportGO:00068201610.019
spermatid differentiationGO:004851540.019
lipid metabolic processGO:00066293810.019
cell adhesionGO:00071553250.019
maintenance of locationGO:00512351120.019
positive regulation of nucleoside metabolic processGO:00459791860.019
regulation of protein transportGO:00512232130.019
cellular response to abiotic stimulusGO:00712141170.019
cell growthGO:00160491600.019
negative regulation of cell migrationGO:00303361020.019
Human
regulation of transmembrane transporter activityGO:0022898740.019
generation of neuronsGO:00486991520.018
negative regulation of intracellular signal transductionGO:19025321830.018
regulation of vesicle mediated transportGO:00606271300.018
positive regulation of locomotionGO:00400171860.018
atp catabolic processGO:00062001570.018
positive regulation of purine nucleotide catabolic processGO:00331231850.018
head developmentGO:00603221080.018
protein acetylationGO:00064731160.018
regulation of apoptotic signaling pathwayGO:20012331750.018
micturitionGO:006007330.018
regulation of ras protein signal transductionGO:00465781550.018
response to steroid hormoneGO:0048545800.018
metencephalon developmentGO:002203720.018
epithelial cell proliferationGO:00506731280.018
regulation of purine nucleotide catabolic processGO:00331212050.018
dna repairGO:00062811980.018
actin filament based processGO:00300292240.018
epithelium migrationGO:00901321190.018
membrane organizationGO:00610242920.018
regenerationGO:003109940.018
blood vessel developmentGO:00015681720.018
regulation of protein localizationGO:00328802960.018
lipid biosynthetic processGO:00086101770.018
angiogenesisGO:00015251470.017
nitrogen compound transportGO:00717051910.017
spermatid developmentGO:000728640.017
positive regulation of immune system processGO:00026842830.017
response to hormoneGO:00097251750.017
response to oxygen levelsGO:00704821000.017
regulation of erk1 and erk2 cascadeGO:0070372990.017
innate immune responseGO:00450871780.017
mitotic cell cycle phase transitionGO:00447721620.017
sodium ion transportGO:0006814610.017
fibroblast growth factor receptor signaling pathway involved in mammary gland specificationGO:006059510.017
regulation of transporter activityGO:0032409820.017
protein acylationGO:00435431380.017
peptidyl lysine modificationGO:00182051440.017
reactive nitrogen species metabolic processGO:200105730.017
gtp metabolic processGO:00460392390.017
regulation of nucleotide catabolic processGO:00308112050.017
organophosphate biosynthetic processGO:00904071630.016
ameboidal type cell migrationGO:00016671350.016
negative regulation of cellular component organizationGO:00511292350.016
cellular response to organic cyclic compoundGO:00714071270.016
posttranscriptional regulation of gene expressionGO:00106082130.016
rna processingGO:00063962550.016
tissue migrationGO:00901301190.016
organelle assemblyGO:00709251760.016
cell cycle phase transitionGO:00447701730.016
hindbrain developmentGO:003090230.016
potassium ion transportGO:0006813620.016
mammary gland morphogenesisGO:006044320.016
cell fate determinationGO:000170930.016
regulation of proteolysisGO:00301622930.016
Human
leukocyte activationGO:00453211640.016
protein catabolic processGO:00301633250.016
second messenger mediated signalingGO:0019932780.016
actin filament based movementGO:0030048170.016
purine ribonucleoside monophosphate catabolic processGO:00091691580.016
wound healingGO:00420601150.016
regulation of small gtpase mediated signal transductionGO:00510561560.015
positive regulation of synaptic transmissionGO:005080640.015
cellular macromolecule catabolic processGO:00442653800.015
negative regulation of phosphorylationGO:00423261740.015
sensory perception of light stimulusGO:0050953350.015
regulation of i kappab kinase nf kappab signalingGO:00431221620.015
epidermis morphogenesisGO:004873030.015
gtp catabolic processGO:00061842370.015
positive regulation of secretion by cellGO:19035321080.015
purine nucleotide biosynthetic processGO:0006164840.015
carbohydrate derivative biosynthetic processGO:19011372070.015
cell divisionGO:00513011680.015
negative regulation of cellular component movementGO:00512711060.015
Human
regulation of lymphocyte activationGO:00512491030.015
neurogenesisGO:00220081690.015
organic acid biosynthetic processGO:0016053970.015
response to metal ionGO:0010038840.014
cytokine productionGO:00018162470.014
negative regulation of synaptic transmissionGO:005080520.014
microtubule based processGO:00070172100.014
response to growth factorGO:00708482050.014
hematopoietic or lymphoid organ developmentGO:00485341860.014
regulation of establishment of protein localizationGO:00702012420.014
lymphocyte activationGO:00466491330.014
negative regulation of hydrolase activityGO:00513461820.014
Human
single organismal cell cell adhesionGO:00163371480.014
organic hydroxy compound transportGO:0015850630.014
protein maturationGO:00516042330.014
Human
response to oxidative stressGO:00069791210.014
potassium ion transmembrane transportGO:0071805600.014
extrinsic apoptotic signaling pathwayGO:00971911190.014
negative regulation of protein phosphorylationGO:00019331400.014
nucleotide biosynthetic processGO:00091651090.014
regulation of cell growthGO:00015581350.014
negative regulation of cytosolic calcium ion concentrationGO:005148110.014
positive regulation of nucleotide catabolic processGO:00308131850.014
positive regulation of cell deathGO:00109422630.014
heart processGO:0003015620.014
associative learningGO:000830610.014
negative regulation of cell cycleGO:00457861930.014
i kappab kinase nf kappab signalingGO:00072491660.014
regulation of cell developmentGO:00602841610.014
cellular metal ion homeostasisGO:00068751460.014
lipid transportGO:0006869900.014
regulation of saliva secretionGO:004687720.014
regulation of cell morphogenesisGO:00226041530.014
regulation of chromosome organizationGO:00330441030.014
neural nucleus developmentGO:0048857470.014
peptidyl serine modificationGO:00182091060.014
spinal cord developmentGO:002151040.014
response to virusGO:00096151260.014
response to bacteriumGO:00096171440.014
visual behaviorGO:000763220.013
muscle system processGO:0003012810.013
regulation of cytoplasmic transportGO:19036491490.013
response to axon injuryGO:004867810.013
regulation of neurogenesisGO:0050767820.013
microtubule cytoskeleton organizationGO:00002261760.013
sequestering of metal ionGO:0051238240.013
protein processingGO:00164852260.013
Human
negative regulation of blood pressureGO:004577630.013
neuron differentiationGO:00301821380.013
organ formationGO:004864530.013
positive regulation of organic acid transportGO:003289230.013
negative regulation of protein processingGO:00109551420.013
Human
circadian behaviorGO:004851220.013
cellular protein catabolic processGO:00442572610.013
immune system developmentGO:00025201950.013
immune effector processGO:00022521590.013
striated muscle contractionGO:0006941520.013
segmentationGO:003528240.013
meiosis iGO:000712740.013
response to extracellular stimulusGO:0009991850.013
protein autophosphorylationGO:00467771230.013
cytokine mediated signaling pathwayGO:00192211090.013
regulation of protein ubiquitinationGO:0031396950.013
single organism reproductive processGO:0044702980.013
neuroblast proliferationGO:000740540.013
regulation of synaptic plasticityGO:004816730.013
cell projection assemblyGO:00300311260.013
response to drugGO:0042493810.013
Human
regulation of system processGO:00440571010.013
negative regulation of immune system processGO:00026831360.013
negative regulation of organelle organizationGO:00106391260.013
macromolecule methylationGO:0043414970.013
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.013
Human
guanosine containing compound metabolic processGO:19010682440.013
regulation of vasculature developmentGO:1901342970.012
single organism cell adhesionGO:00986021790.012
regulation of immune responseGO:00507762010.012
chemotaxisGO:00069351570.012
regulation of mitotic cell cycleGO:00073461890.012
stress activated mapk cascadeGO:0051403930.012
modification dependent macromolecule catabolic processGO:00436322120.012
inner ear morphogenesisGO:004247240.012
mitochondrion organizationGO:00070051560.012
rhythmic behaviorGO:000762220.012
protein localization to organelleGO:00333652800.012
organic anion transportGO:00157111030.012
oocyte developmentGO:004859910.012
copulationGO:000762010.012
regulation of protein catabolic processGO:00421761550.012
peptidyl lysine acetylationGO:00183941010.012
regulation of dna metabolic processGO:00510521530.012
behaviorGO:00076101120.012
regulation of cell divisionGO:00513021160.012
regulation of protein modification by small protein conjugation or removalGO:19033201070.012
carboxylic acid biosynthetic processGO:0046394970.012
endomembrane system organizationGO:00102561960.012
regulation of gtpase activityGO:00430871800.012
response to fungusGO:000962040.012
taxisGO:00423301570.012
epithelium developmentGO:00604292270.012
cellular response to growth factor stimulusGO:00713631970.012
methylationGO:00322591060.012
guanosine containing compound catabolic processGO:19010692390.012
stress activated protein kinase signaling cascadeGO:0031098940.012
regulation of defense responseGO:00313471540.012
response to decreased oxygen levelsGO:0036293960.012
ribose phosphate biosynthetic processGO:0046390820.012
actin cytoskeleton organizationGO:00300362070.012
lipid localizationGO:00108761060.012
sequestering of calcium ionGO:0051208170.012
response to hypoxiaGO:0001666960.012
negative regulation of apoptotic signaling pathwayGO:2001234970.012
cardiac cell fate determinationGO:006091330.012
regulation of blood circulationGO:1903522590.012
proteasomal protein catabolic processGO:00104981760.012
regulation of protein processingGO:00706131500.012
Human
regulation of keratinocyte migrationGO:005154740.012
response to light stimulusGO:0009416870.012
ribonucleotide biosynthetic processGO:0009260810.012
sex determinationGO:000753030.012
ventral spinal cord developmentGO:002151710.012
positive regulation of lymphocyte activationGO:0051251730.012
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.012
positive regulation of keratinocyte migrationGO:005154940.012
cellular response to organonitrogen compoundGO:00714171240.012
nuclear divisionGO:00002801280.011
Mouse
intrinsic apoptotic signaling pathwayGO:00971931270.011
protein oligomerizationGO:00512591730.011
regulation of cellular component biogenesisGO:00440872810.011
activation of mapk activity by adrenergic receptor signaling pathwayGO:007188330.011
positive regulation of erk1 and erk2 cascadeGO:0070374750.011
modification dependent protein catabolic processGO:00199412090.011
jnk cascadeGO:0007254800.011
regulation of multi organism processGO:00439001570.011
positive regulation of proteolysisGO:00458621420.011
positive regulation of immune responseGO:00507781590.011
positive regulation of programmed cell deathGO:00430682490.011
vasodilationGO:004231140.011
proteolysis involved in cellular protein catabolic processGO:00516032440.011
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.011
nucleocytoplasmic transportGO:00069131760.011
regulation of nervous system developmentGO:0051960880.011
alcohol metabolic processGO:00060661140.011
internal protein amino acid acetylationGO:00064751010.011
endocytosisGO:00068971590.011
regulation of peptidase activityGO:00525471800.011
Human
positive regulation of cell cycleGO:00457871400.011
action potentialGO:0001508340.011
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.011
protein localization to membraneGO:00726571600.011
response to alcoholGO:0097305640.011
positive regulation of cell activationGO:0050867810.011
cardiac muscle contractionGO:0060048340.011
positive regulation of gtpase activityGO:00435471660.011
serotonin transportGO:000683730.011
dephosphorylationGO:00163112090.011
reproductionGO:0000003630.011
Mouse
regulation of heart rateGO:0002027380.011
positive regulation of organelle organizationGO:00106381950.011
histone acetylationGO:0016573930.011

DPEP3 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:8634310.051
sensory system diseaseDOID:00501552030.051
musculoskeletal system diseaseDOID:172230.037
eye and adnexa diseaseDOID:14921500.036
eye diseaseDOID:56141490.036
retinal diseaseDOID:56791180.026
immune system diseaseDOID:29141550.023
muscular diseaseDOID:00800001140.023
muscle tissue diseaseDOID:661130.022
disease of metabolismDOID:00146672950.021
cardiovascular system diseaseDOID:12871060.018
retinal degenerationDOID:8466890.018
inherited metabolic disorderDOID:6552420.016
myopathyDOID:4231040.015
cancerDOID:1621670.014
disease of cellular proliferationDOID:145661740.014
organ system cancerDOID:00506861640.014
hematopoietic system diseaseDOID:741000.014
neurodegenerative diseaseDOID:12891020.012
central nervous system diseaseDOID:3311860.012