Homo sapiens

84 known processes

DISC1

disrupted in schizophrenia 1

(Aliases: FLJ13381,KIAA0457,FLJ25311,SCZD9,FLJ41105,C1orf136,FLJ21640)

DISC1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
adult locomotory behaviorGO:000834410.602
cell developmentGO:00484683280.379
regulation of microtubule based processGO:0032886740.367
photoreceptor cell maintenanceGO:0045494130.268
regulation of atrial cardiac muscle cell membrane repolarizationGO:006037240.258
microtubule based processGO:00070172100.255
rho protein signal transductionGO:0007266260.234
microtubule cytoskeleton organizationGO:00002261760.217
small gtpase mediated signal transductionGO:0007264780.194
generation of neuronsGO:00486991520.190
actin filament based processGO:00300292240.189
sensory perception of soundGO:0007605370.170
establishment of nucleus localizationGO:004002310.167
regulation of cellular amine metabolic processGO:0033238110.164
cytokinesisGO:0000910960.153
regulation of blood circulationGO:1903522590.150
microtubule polymerization or depolymerizationGO:0031109370.149
cell projection morphogenesisGO:00488581290.147
regulation of cytoskeleton organizationGO:00514931770.146
sensory perceptionGO:00076001030.140
cell projection organizationGO:00300302520.132
Mouse
post embryonic developmentGO:000979120.130
male genitalia developmentGO:003053910.130
membrane organizationGO:00610242920.130
retina homeostasisGO:0001895420.125
cell morphogenesisGO:00009022960.124
regulation of cellular component movementGO:00512703340.117
regulation of rho protein signal transductionGO:0035023790.114
mitotic cell cycleGO:00002783260.109
cellular amine metabolic processGO:0044106410.104
axon extensionGO:0048675130.102
guanosine containing compound metabolic processGO:19010682440.102
positive regulation of axon extensionGO:004577340.102
peripheral nervous system developmentGO:000742220.100
positive regulation of nucleotide catabolic processGO:00308131850.100
forebrain generation of neuronsGO:002187230.099
nervous system developmentGO:00073992930.099
central nervous system projection neuron axonogenesisGO:002195230.099
mitotic cell cycle processGO:19030472860.098
regulation of cell developmentGO:00602841610.098
protein oligomerizationGO:00512591730.098
regulation of nucleotide catabolic processGO:00308112050.097
ras protein signal transductionGO:0007265730.094
regulation of anatomical structure morphogenesisGO:00226032860.094
regulation of cell differentiationGO:00455953930.094
golgi organizationGO:0007030380.094
heart processGO:0003015620.093
guanosine containing compound catabolic processGO:19010692390.093
cellular component morphogenesisGO:00329893140.093
regulation of ras gtpase activityGO:00323181280.091
gtp metabolic processGO:00460392390.091
regulation of cellular ketone metabolic processGO:0010565500.091
regulation of cellular component biogenesisGO:00440872810.090
locomotory behaviorGO:000762610.087
regulation of actin filament based processGO:00329701410.085
cardiac muscle cell contractionGO:008600340.084
amine metabolic processGO:0009308440.084
central nervous system neuron axonogenesisGO:002195530.082
regulation of cellular amino acid metabolic processGO:000652160.080
anatomical structure homeostasisGO:00602491000.080
regulation of neuron differentiationGO:0045664700.079
Mouse
cell divisionGO:00513011680.079
positive regulation of nucleoside metabolic processGO:00459791860.075
positive regulation of cellular component biogenesisGO:00440891580.073
regulation of cell projection organizationGO:00313441070.073
Mouse
positive regulation of purine nucleotide metabolic processGO:19005442270.073
regulation of heart contractionGO:0008016500.073
neuron projection morphogenesisGO:0048812500.072
neuron developmentGO:00486661130.071
Mouse
cardiac muscle contractionGO:0060048340.069
positive regulation of catabolic processGO:00098963100.068
Mouse
positive regulation of cellular catabolic processGO:00313312840.068
Mouse
positive regulation of cell developmentGO:0010720920.068
regulation of neuron projection developmentGO:0010975570.067
Mouse
sensory perception of mechanical stimulusGO:0050954370.067
heart contractionGO:0060047620.066
regulation of gtp catabolic processGO:00331241800.066
neurological system processGO:00508771630.066
regulation of microtubule polymerization or depolymerizationGO:0031110270.066
neurogenesisGO:00220081690.065
gtp catabolic processGO:00061842370.064
system processGO:00030083490.064
cell morphogenesis involved in differentiationGO:00009041440.064
purine ribonucleoside triphosphate metabolic processGO:00092054110.063
protein depolymerizationGO:0051261300.062
regulation of microtubule cytoskeleton organizationGO:0070507610.062
positive regulation of gtpase activityGO:00435471660.061
purine ribonucleoside catabolic processGO:00461303980.060
positive regulation of ras gtpase activityGO:00323201170.060
regulation of membrane potentialGO:0042391950.058
cell part morphogenesisGO:00329901370.058
protein homooligomerizationGO:00512601000.058
ribonucleotide catabolic processGO:00092614050.057
negative regulation of cellular component movementGO:00512711060.057
growthGO:00400072020.057
nucleoside triphosphate metabolic processGO:00091414220.055
cellular potassium ion transportGO:0071804600.055
macromolecular complex disassemblyGO:0032984600.055
positive regulation of rho protein signal transductionGO:003502540.054
central nervous system neuron developmentGO:002195470.054
regulation of metal ion transportGO:00109591200.054
purine nucleoside triphosphate metabolic processGO:00091444120.054
purine ribonucleoside metabolic processGO:00461284370.053
lysosomal transportGO:0007041330.052
cation transportGO:00068123310.050
microtubule depolymerizationGO:0007019180.050
positive regulation of rac gtpase activityGO:0032855310.050
positive regulation of purine nucleotide catabolic processGO:00331231850.049
monovalent inorganic cation transportGO:00156721280.049
multicellular organismal signalingGO:0035637340.048
sleepGO:003043120.048
regulation of protein depolymerizationGO:1901879220.048
nucleoside catabolic processGO:00091644080.048
regulation of ras protein signal transductionGO:00465781550.047
positive regulation of developmental processGO:00510943140.047
vesicle mediated transportGO:00161923710.046
neuron projection developmentGO:00311751060.046
Mouse
regulation of system processGO:00440571010.045
actin cytoskeleton organizationGO:00300362070.045
establishment of organelle localizationGO:0051656590.045
actin filament based movementGO:0030048170.045
purine nucleoside catabolic processGO:00061523980.044
nucleus localizationGO:005164710.043
cell growthGO:00160491600.043
intracellular protein transportGO:00068862700.043
regulation of rho gtpase activityGO:0032319660.042
regulation of circadian sleep wake cycleGO:004274920.042
endomembrane system organizationGO:00102561960.042
positive regulation of cell differentiationGO:00455972110.042
circadian sleep wake cycleGO:004274520.042
regulation of cell morphogenesis involved in differentiationGO:0010769830.041
neuron differentiationGO:00301821380.041
Mouse
axon cargo transportGO:000808820.041
protein localization to organelleGO:00333652800.041
purine nucleoside triphosphate catabolic processGO:00091463920.041
cellular amino acid metabolic processGO:00065201160.041
purine nucleotide catabolic processGO:00061954050.040
positive regulation of cell morphogenesis involved in differentiationGO:0010770500.040
cellular protein complex disassemblyGO:0043624360.040
regulation of nucleotide metabolic processGO:00061402690.040
positive regulation of organelle organizationGO:00106381950.040
cellular ketone metabolic processGO:0042180800.039
cell junction organizationGO:0034330790.039
protein complex disassemblyGO:0043241520.038
behaviorGO:00076101120.038
regulation of gtpase activityGO:00430871800.037
cardiac conductionGO:0061337230.037
inorganic ion transmembrane transportGO:00986602310.037
golgi vesicle transportGO:0048193800.037
cell projection assemblyGO:00300311260.037
rhythmic behaviorGO:000762220.037
negative regulation of protein metabolic processGO:00512483910.036
mitotic nuclear divisionGO:00070671190.036
tissue homeostasisGO:0001894630.036
organophosphate catabolic processGO:00464344300.035
positive regulation of neurogenesisGO:0050769490.035
nucleoside triphosphate catabolic processGO:00091433940.035
axon developmentGO:0061564340.034
neuron projection extensionGO:1990138140.034
single organism cellular localizationGO:19025803320.033
actin mediated cell contractionGO:0070252120.033
positive regulation of gtp catabolic processGO:00331261660.033
biological adhesionGO:00226103310.032
cellular component disassemblyGO:0022411920.032
regulation of nucleoside metabolic processGO:00091182090.032
cell substrate adhesionGO:00315891320.031
regulation of locomotionGO:00400123290.031
neuromuscular junction developmentGO:000752830.031
cellular protein complex assemblyGO:00436231880.031
positive regulation of cytoskeleton organizationGO:0051495830.031
circadian sleep wake cycle sleepGO:005080220.031
cation transmembrane transportGO:00986552380.031
sodium ion transportGO:0006814610.031
purine containing compound catabolic processGO:00725234110.030
positive regulation of rho gtpase activityGO:0032321560.030
ribonucleoside catabolic processGO:00424544060.030
negative regulation of cellular component organizationGO:00511292350.030
nuclear divisionGO:00002801280.030
negative regulation of protein depolymerizationGO:1901880170.030
ribonucleoside triphosphate metabolic processGO:00091994120.030
positive regulation of actin filament polymerizationGO:0030838380.029
positive regulation of cellular component movementGO:00512721810.029
organelle localizationGO:0051640840.029
oocyte differentiationGO:000999420.029
establishment of protein localization to membraneGO:00901501210.029
oocyte developmentGO:004859910.029
multicellular organismal homeostasisGO:0048871670.028
forebrain neuron differentiationGO:002187930.028
positive regulation of cell projection organizationGO:0031346640.028
positive regulation of nucleotide metabolic processGO:00459812300.028
protein targetingGO:00066051870.028
positive regulation of transporter activityGO:0032411320.028
taxisGO:00423301570.027
matingGO:000761810.027
regulation of cell morphogenesisGO:00226041530.027
inorganic cation transmembrane transportGO:00986621940.027
establishment of protein localization to plasma membraneGO:0090002680.027
cell matrix adhesionGO:0007160850.027
striated muscle contractionGO:0006941520.027
negative regulation of multicellular organismal processGO:00512413170.026
purine ribonucleotide catabolic processGO:00091544040.026
axonogenesisGO:0007409310.026
multicellular organismal agingGO:001025930.026
positive regulation of hydrolase activityGO:00513453310.026
protein targeting to membraneGO:0006612420.026
regulation of small gtpase mediated signal transductionGO:00510561560.026
regulation of growthGO:00400081650.026
regulation of protein polymerizationGO:0032271630.026
microtubule based movementGO:0007018320.026
regulation of mitotic cell cycleGO:00073461890.025
negative regulation of phosphorus metabolic processGO:00105632670.025
positive regulation of cell growthGO:0030307480.025
purine ribonucleoside triphosphate catabolic processGO:00092073910.025
plasma membrane organizationGO:00070091150.025
regulation of neurogenesisGO:0050767820.024
transmission of nerve impulseGO:0019226110.024
female gamete generationGO:000729220.024
negative regulation of organelle organizationGO:00106391260.024
ribonucleoside triphosphate catabolic processGO:00092033910.024
negative regulation of phosphate metabolic processGO:00459362670.024
focal adhesion assemblyGO:0048041300.024
negative regulation of protein phosphorylationGO:00019331400.023
response to growth factorGO:00708482050.023
regulation of actin cytoskeleton organizationGO:00329561160.023
determination of adult lifespanGO:000834020.023
anatomical structure formation involved in morphogenesisGO:00486462840.022
nucleoside phosphate catabolic processGO:19012924120.022
peptidyl serine modificationGO:00182091060.022
organelle fissionGO:00482851490.022
cell cycle phase transitionGO:00447701730.022
forebrain neuron developmentGO:002188420.021
regulation of purine nucleotide metabolic processGO:19005422640.021
negative regulation of microtubule polymerization or depolymerizationGO:0031111170.021
cell adhesionGO:00071553250.021
regulation of purine nucleotide catabolic processGO:00331212050.021
maintenance of location in cellGO:0051651620.021
positive regulation of nervous system developmentGO:0051962540.021
actin filament organizationGO:00070151280.021
negative regulation of cell developmentGO:0010721480.020
glycosyl compound catabolic processGO:19016584130.020
positive regulation of cellular component organizationGO:00511303760.020
post golgi vesicle mediated transportGO:0006892360.020
positive regulation of ion transmembrane transporter activityGO:0032414290.020
peptidyl serine phosphorylationGO:00181051010.019
regulation of protein complex disassemblyGO:0043244280.019
telencephalon developmentGO:0021537170.019
Mouse
cellular chemical homeostasisGO:00550821800.019
Mouse
single organism membrane organizationGO:00448022680.019
developmental cell growthGO:0048588180.019
negative regulation of programmed cell deathGO:00430693210.019
protein localization to membraneGO:00726571600.019
actin cytoskeleton reorganizationGO:0031532370.018
regulation of potassium ion transmembrane transporter activityGO:1901016160.018
maintenance of protein locationGO:0045185570.018
nuclear migrationGO:000709710.018
engulfment of apoptotic cellGO:004365220.018
cellular macromolecular complex assemblyGO:00346223240.018
positive regulation of potassium ion transportGO:0043268150.018
regulation of proteolysisGO:00301622930.018
Mouse
adult behaviorGO:0030534180.018
central nervous system developmentGO:00074171230.018
Mouse
cell junction assemblyGO:0034329670.018
muscle contractionGO:0006936730.018
sensory perception of smellGO:000760820.018
ion transmembrane transportGO:00342203380.018
nerve developmentGO:002167540.018
positive regulation of potassium ion transmembrane transportGO:1901381120.017
cellular response to growth factor stimulusGO:00713631970.017
mitotic cell cycle phase transitionGO:00447721620.017
positive regulation of growthGO:0045927580.017
regulation of protein localizationGO:00328802960.017
regulation of transferase activityGO:00513383550.017
action potentialGO:0001508340.017
negative regulation of cellular protein metabolic processGO:00322693530.017
adherens junction organizationGO:0034332360.017
regulation of peptidyl serine phosphorylationGO:0033135500.017
negative regulation of phosphorylationGO:00423261740.017
protein localization to nucleusGO:00345041360.017
regulation of circadian sleep wake cycle sleepGO:004518720.017
negative regulation of protein modification processGO:00314002000.017
establishment or maintenance of microtubule cytoskeleton polarityGO:003095120.017
negative regulation of developmental processGO:00510932470.016
negative regulation of intracellular signal transductionGO:19025321830.016
regulation of cellular response to stressGO:00801352440.016
cell morphogenesis involved in neuron differentiationGO:0048667440.016
single organism reproductive processGO:0044702980.016
maintenance of locationGO:00512351120.016
protein tetramerizationGO:0051262470.016
regulation of protein kinase activityGO:00458592890.016
regulation of nervous system developmentGO:0051960880.016
metal ion transportGO:00300012720.016
membrane hyperpolarizationGO:006008110.016
regulation of cell cycle processGO:00105642660.015
reproductive processGO:00224141060.015
response to endoplasmic reticulum stressGO:0034976490.015
transmembrane transportGO:00550853990.015
spermatid differentiationGO:004851540.015
protein catabolic processGO:00301633250.015
Mouse
response to oxidative stressGO:00069791210.015
positive regulation of neuron projection developmentGO:0010976340.015
cranial nerve developmentGO:002154540.015
regulation of sodium ion transportGO:0002028240.015
regulation of axonogenesisGO:0050770160.015
associative learningGO:000830610.015
carbohydrate derivative biosynthetic processGO:19011372070.015
multi organism reproductive processGO:0044703540.015
negative regulation of cell deathGO:00605483450.015
regulation of microtubule depolymerizationGO:0031114120.015
central nervous system neuron differentiationGO:002195390.015
regulation of cell growthGO:00015581350.014
regulation of striated muscle contractionGO:0006942370.014
dna replicationGO:00062601160.014
maintenance of protein location in cellGO:0032507560.014
response to cytokineGO:00340972320.014
multi organism cellular processGO:00447641560.014
brain developmentGO:0007420970.014
Mouse
nucleotide catabolic processGO:00091664080.014
negative regulation of cellular amino acid metabolic processGO:004576320.014
endocytosisGO:00068971590.014
meiotic chromosome segregationGO:004513240.014
proteolysis involved in cellular protein catabolic processGO:00516032440.014
Mouse
cell cell junction organizationGO:0045216690.014
negative regulation of transferase activityGO:00513481240.014
regulation of cell motilityGO:20001452990.014
positive regulation of apoptotic processGO:00430652460.014
negative regulation of cell cycleGO:00457861930.014
regulation of peptidase activityGO:00525471800.014
potassium ion transmembrane transportGO:0071805600.014
negative regulation of cellular amine metabolic processGO:003323930.014
cell substrate junction assemblyGO:0007044350.014
reproductionGO:0000003630.014
protein localization to plasma membraneGO:0072659930.013
actin filament polymerizationGO:0030041450.013
negative regulation of cell motilityGO:20001461040.013
negative regulation of catalytic activityGO:00430863350.013
calcium ion homeostasisGO:00550741220.013
Mouse
negative regulation of potassium ion transmembrane transporter activityGO:190101730.013
negative regulation of microtubule depolymerizationGO:0007026120.013
regulation of cellular component sizeGO:0032535820.013
cytokine productionGO:00018162470.013
regulation of heart rateGO:0002027380.013
blood circulationGO:00080151130.013
cardiac muscle cell action potential involved in contractionGO:0086002210.013
nitrogen compound transportGO:00717051910.013
protein polymerizationGO:0051258710.013
regulation of ion transmembrane transporter activityGO:0032412720.013
regulation of actin polymerization or depolymerizationGO:0008064560.013
regulation of potassium ion transmembrane transportGO:1901379200.013
intrinsic apoptotic signaling pathwayGO:00971931270.013
regulation of cell cycle phase transitionGO:19019871260.013
cerebral cortex radially oriented cell migrationGO:002179910.013
Mouse
interspecies interaction between organismsGO:00444191560.013
regulation of cell cycleGO:00517263930.013
circadian behaviorGO:004851220.013
symbiosis encompassing mutualism through parasitismGO:00444031560.012
potassium ion transportGO:0006813620.012
chromosome segregationGO:00070591140.012
regulation of establishment of protein localizationGO:00702012420.012
oogenesisGO:004847720.012
rhythmic processGO:0048511310.012
blastocyst developmentGO:000182430.012
muscle cell differentiationGO:0042692630.012
nucleocytoplasmic transportGO:00069131760.012
response to virusGO:00096151260.012
response to fungusGO:000962040.012
regulation of transporter activityGO:0032409820.012
sister chromatid segregationGO:0000819540.012
regulation of endopeptidase activityGO:00525481700.012
regulation of homeostatic processGO:00328441210.012
muscle system processGO:0003012810.012
regulation of membrane repolarizationGO:0060306160.012
regulation of cell migrationGO:00303342890.012
negative regulation of blood circulationGO:190352340.012
mitotic sister chromatid segregationGO:0000070530.011
regulation of protein complex assemblyGO:00432541470.011
negative regulation of locomotionGO:00400131180.011
positive regulation of transportGO:00510503360.011
regulation of cell adhesionGO:00301551660.011
cellular metal ion homeostasisGO:00068751460.011
Mouse
regulation of mitotic cell cycle phase transitionGO:19019901180.011
signal transduction by phosphorylationGO:00230142970.011
neuroblast proliferationGO:000740540.011
mapk cascadeGO:00001652880.011
muscle cell cellular homeostasisGO:004671630.011
negative regulation of hydrolase activityGO:00513461820.011
regulation of secretion by cellGO:19035301770.011
limbic system developmentGO:002176130.011
cell fate determinationGO:000170930.011
rna processingGO:00063962550.011
protein secretionGO:0009306980.011
regulation of chromosome organizationGO:00330441030.011
cellular macromolecule catabolic processGO:00442653800.011
Mouse
regulation of protein secretionGO:0050708860.011
regulation of actin filament polymerizationGO:0030833500.011
positive regulation of immune system processGO:00026842830.011
sequestering of metal ionGO:0051238240.010
muscle structure developmentGO:0061061980.010
actin polymerization or depolymerizationGO:0008154560.010
chemotaxisGO:00069351570.010
regulation of ion transmembrane transportGO:00347651320.010
positive regulation of ion transmembrane transportGO:0034767400.010
microtubule based transportGO:0010970210.010
regulation of multi organism processGO:00439001570.010
cellular response to lipidGO:00713961270.010
positive regulation of potassium ion transmembrane transporter activityGO:190101880.010
spermatid developmentGO:000728640.010
positive regulation of protein polymerizationGO:0032273450.010
regulation of neurotransmitter secretionGO:004692830.010
positive regulation of programmed cell deathGO:00430682490.010
tripartite regional subdivisionGO:000735120.010

DISC1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
neurodegenerative diseaseDOID:12891020.163
central nervous system diseaseDOID:3311860.163
nervous system diseaseDOID:8634310.163
musculoskeletal system diseaseDOID:172230.104
muscular diseaseDOID:00800001140.104
cardiovascular system diseaseDOID:12871060.068
muscle tissue diseaseDOID:661130.067
myopathyDOID:4231040.057
muscular dystrophyDOID:9884510.057
cardiomyopathyDOID:0050700500.030
intrinsic cardiomyopathyDOID:0060036500.030
heart diseaseDOID:114680.030
spinocerebellar degenerationDOID:2478270.030
sensory system diseaseDOID:00501552030.021
disease of cellular proliferationDOID:145661740.020
cancerDOID:1621670.020
organ system cancerDOID:00506861640.019
eye and adnexa diseaseDOID:14921500.015
eye diseaseDOID:56141490.015
disease of metabolismDOID:00146672950.010
disease of mental healthDOID:150700.004
cognitive disorderDOID:1561290.002
psychotic disorderDOID:246880.001
schizophreniaDOID:541980.001