Homo sapiens

37 known processes

PCOLCE

procollagen C-endopeptidase enhancer

(Aliases: PCPE,PCPE1)

PCOLCE biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of mesenchymal stem cell differentiationGO:200074140.528
extracellular structure organizationGO:0043062410.400
regulation of locomotionGO:00400123290.371
negative regulation of multicellular organismal processGO:00512413170.362
mesenchyme developmentGO:0060485590.349
peptide cross linkingGO:0018149120.344
extracellular matrix organizationGO:0030198410.330
multicellular organismal macromolecule metabolic processGO:0044259290.319
cell adhesionGO:00071553250.301
response to oxygen containing compoundGO:19017003690.277
collagen metabolic processGO:0032963280.242
positive regulation of developmental processGO:00510943140.239
skeletal system developmentGO:0001501790.233
regulation of mesenchymal stem cell proliferationGO:190246010.232
neural crest cell developmentGO:001403230.216
stem cell developmentGO:0048864690.207
regulation of cellular component movementGO:00512703340.202
stem cell differentiationGO:0048863930.193
positive regulation of locomotionGO:00400171860.187
cell morphogenesisGO:00009022960.182
positive regulation of cell proliferationGO:00082843010.175
positive regulation of cellular component movementGO:00512721810.161
sulfur compound metabolic processGO:00067901010.160
circulatory system developmentGO:00723592620.159
cell substrate adhesionGO:00315891320.158
chondroitin sulfate metabolic processGO:003020470.156
endoderm developmentGO:0007492330.153
cellular component morphogenesisGO:00329893140.146
multicellular organismal metabolic processGO:0044236340.142
positive regulation of fibroblast migrationGO:001076330.133
plasminogen activationGO:0031639110.132
positive regulation of cell migrationGO:00303351720.126
osteoblast differentiationGO:0001649920.120
regulation of cell migrationGO:00303342890.117
blood vessel morphogenesisGO:00485141620.112
regulation of cell motilityGO:20001452990.111
cell type specific apoptotic processGO:00972851250.110
ossificationGO:00015031210.109
biological adhesionGO:00226103310.108
cartilage developmentGO:0051216310.107
neural crest cell migrationGO:000175520.107
positive regulation of endothelial cell apoptotic processGO:200035380.104
chondroitin sulfate proteoglycan metabolic processGO:0050654100.103
mesenchymal cell differentiationGO:0048762520.103
gastrulationGO:0007369510.101
rho protein signal transductionGO:0007266260.101
regulation of proteolysisGO:00301622930.099
biomineral tissue developmentGO:0031214390.098
cell developmentGO:00484683280.097
blood vessel developmentGO:00015681720.096
anatomical structure formation involved in morphogenesisGO:00486462840.089
defense responseGO:00069523150.085
cardiovascular system developmentGO:00723582620.079
angiogenesisGO:00015251470.079
regulation of cell differentiationGO:00455953930.079
negative regulation of protein metabolic processGO:00512483910.075
negative regulation of embryonic developmentGO:004599240.075
positive regulation of cytokine productionGO:00018191670.074
cell morphogenesis involved in differentiationGO:00009041440.071
vasculature developmentGO:00019441810.069
response to abiotic stimulusGO:00096283360.069
positive regulation of cell deathGO:00109422630.067
positive regulation of apoptotic processGO:00430652460.065
soft palate developmentGO:006002330.061
ameboidal type cell migrationGO:00016671350.061
regulation of peptidase activityGO:00525471800.060
epithelium developmentGO:00604292270.059
mesenchymal stem cell proliferationGO:009716810.058
negative regulation of cellular response to growth factor stimulusGO:0090288410.057
connective tissue developmentGO:0061448390.057
regulation of cartilage developmentGO:0061035120.057
mapk cascadeGO:00001652880.057
enzyme linked receptor protein signaling pathwayGO:00071673030.056
negative regulation of gastrulationGO:200054240.056
cellular response to transforming growth factor beta stimulusGO:0071560940.056
positive regulation of cell differentiationGO:00455972110.056
innate immune responseGO:00450871780.053
endothelial cell cell adhesionGO:007160310.053
response to waterGO:000941520.053
response to acid chemicalGO:0001101660.051
basement membrane organizationGO:007171130.050
cytokine productionGO:00018162470.049
protein oligomerizationGO:00512591730.048
negative regulation of protein maturationGO:19033181420.048
regulation of transferase activityGO:00513383550.048
regulation of endodermal cell differentiationGO:190322430.048
positive regulation of mesenchymal stem cell proliferationGO:190246210.048
digestive system developmentGO:0055123750.047
post embryonic developmentGO:000979120.047
mesenchymal cell developmentGO:0014031500.047
positive regulation of programmed cell deathGO:00430682490.046
regulation of immune responseGO:00507762010.045
response to woundingGO:00096111680.045
digestive tract morphogenesisGO:0048546560.045
dendritic cell antigen processing and presentationGO:000246810.044
negative regulation of protein activation cascadeGO:200025870.043
regulation of anatomical structure morphogenesisGO:00226032860.043
regenerationGO:003109940.040
positive regulation of cellular component organizationGO:00511303760.040
regulation of cellular response to growth factor stimulusGO:0090287760.040
response to drugGO:0042493810.039
regulation of protein serine threonine kinase activityGO:00719001790.039
cellular amino acid metabolic processGO:00065201160.039
negative regulation of cellular protein metabolic processGO:00322693530.039
positive regulation of immune responseGO:00507781590.039
transforming growth factor beta activationGO:003636310.037
regulation of protein secretionGO:0050708860.036
sensory perception of light stimulusGO:0050953350.036
regulation of kinase activityGO:00435493140.036
response to molecule of bacterial originGO:0002237820.036
positive regulation of mapk cascadeGO:00434101900.035
detection of mechanical stimulusGO:005098240.035
peptidyl tyrosine modificationGO:00182121700.035
epithelial cell differentiationGO:00308551410.035
inflammatory responseGO:0006954790.034
regulation of protein kinase activityGO:00458592890.034
regulation of endothelial cell apoptotic processGO:2000351240.034
response to biotic stimulusGO:00096072760.033
vesicle mediated transportGO:00161923710.033
response to radiationGO:00093141510.033
protein maturationGO:00516042330.033
immune responseGO:00069553070.032
bone developmentGO:0060348260.032
proteoglycan metabolic processGO:0006029290.031
cellular response to endogenous stimulusGO:00714953360.031
visual perceptionGO:0007601270.030
regulation of defense responseGO:00313471540.030
zymogen activationGO:0031638700.029
negative regulation of developmental processGO:00510932470.029
detection of mechanical stimulus involved in sensory perceptionGO:005097410.029
regulation of mapk cascadeGO:00434082620.029
negative regulation of protein modification processGO:00314002000.029
cellular ketone metabolic processGO:0042180800.029
negative regulation of hydrolase activityGO:00513461820.028
tube morphogenesisGO:0035239950.028
positive regulation of phosphorylationGO:00423273940.028
apoptotic signaling pathwayGO:00971902680.028
negative regulation of cell deathGO:00605483450.027
single organism cell adhesionGO:00986021790.027
signal transduction by phosphorylationGO:00230142970.027
positive regulation of kinase activityGO:00336742040.027
monocarboxylic acid metabolic processGO:00327871850.026
response to axon injuryGO:004867810.026
small gtpase mediated signal transductionGO:0007264780.026
lipopolysaccharide transportGO:001592020.026
response to organonitrogen compoundGO:00102431560.026
blastoderm segmentationGO:000735020.026
endomembrane system organizationGO:00102561960.026
transforming growth factor beta receptor signaling pathwayGO:0007179760.026
protein catabolic processGO:00301633250.026
endodermal cell differentiationGO:0035987310.025
positive regulation of immune system processGO:00026842830.025
aminoglycan metabolic processGO:0006022390.025
positive regulation of epithelial cell proliferation involved in wound healingGO:006005430.025
response to inorganic substanceGO:00100351270.025
negative regulation of cellular component movementGO:00512711060.025
cellular macromolecule catabolic processGO:00442653800.025
protein heterotrimerizationGO:007020840.024
transforming growth factor beta productionGO:0071604140.024
negative regulation of catalytic activityGO:00430863350.024
regulation of nitric oxide mediated signal transductionGO:001074920.024
negative regulation of cell proliferationGO:00082852280.024
mucopolysaccharide metabolic processGO:1903510270.024
determination of adult lifespanGO:000834020.024
fibroblast growth factor receptor signaling pathwayGO:0008543260.024
locomotory behaviorGO:000762610.023
formation of primary germ layerGO:0001704420.023
regulation of cytokine productionGO:00018172320.023
negative regulation of epithelial cell migrationGO:0010633380.023
chondrocyte differentiationGO:0002062170.023
positive regulation of cell motilityGO:20001471770.022
negative regulation of nitric oxide mediated signal transductionGO:001075120.022
lipid transportGO:0006869900.022
wound healingGO:00420601150.022
response to external biotic stimulusGO:00432072610.022
protein processingGO:00164852260.022
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.022
negative regulation of proteolysisGO:00458611320.022
response to nitrogen compoundGO:19016981840.022
purine nucleoside catabolic processGO:00061523980.022
ras protein signal transductionGO:0007265730.021
positive regulation of transportGO:00510503360.021
response to growth factorGO:00708482050.021
regulation of cellular response to stressGO:00801352440.021
regulation of secretionGO:00510461940.021
substrate adhesion dependent cell spreadingGO:0034446410.021
endothelial cell apoptotic processGO:0072577260.021
negative regulation of phosphate metabolic processGO:00459362670.021
nucleotide catabolic processGO:00091664080.021
regulation of cysteine type endopeptidase activityGO:20001161270.021
regulation of innate immune responseGO:0045088970.021
positive regulation of cellular catabolic processGO:00313312840.021
response to retinoic acidGO:0032526330.020
positive regulation of transferase activityGO:00513472270.020
response to other organismGO:00517072610.020
activation of immune responseGO:00022531140.020
transmembrane transportGO:00550853990.020
ion transmembrane transportGO:00342203380.020
embryonic morphogenesisGO:0048598850.020
regulation of stem cell differentiationGO:2000736560.020
response to cytokineGO:00340972320.020
intracellular protein transportGO:00068862700.020
negative regulation of cell cycleGO:00457861930.020
regulation of secretion by cellGO:19035301770.020
positive regulation of cellular amino acid metabolic processGO:004576430.019
regulation of response to external stimulusGO:00321012220.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.019
cell projection organizationGO:00300302520.019
positive regulation of stem cell differentiationGO:2000738290.019
digestive tract developmentGO:0048565750.019
negative regulation of ectodermal cell fate specificationGO:004266610.019
regulation of protein processingGO:00706131500.019
secretion by cellGO:00329402260.019
regulation of behaviorGO:0050795820.019
endothelial cell morphogenesisGO:000188620.019
regulation of cellular amine metabolic processGO:0033238110.019
negative regulation of cellular component organizationGO:00511292350.019
multicellular organismal agingGO:001025930.019
regulation of jnk cascadeGO:0046328730.019
regulation of nucleotide metabolic processGO:00061402690.019
cellular response to acid chemicalGO:0071229440.019
single organismal cell cell adhesionGO:00163371480.019
blood vessel remodelingGO:000197420.019
embryo developmentGO:00097901230.019
negative regulation of intracellular signal transductionGO:19025321830.019
cellular protein catabolic processGO:00442572610.019
protein heterooligomerizationGO:0051291160.018
s shaped body morphogenesisGO:007205040.018
positive regulation of protein kinase activityGO:00458601900.018
positive regulation of organelle organizationGO:00106381950.018
sensory organ developmentGO:0007423520.018
regulation of cell adhesionGO:00301551660.018
carbohydrate derivative biosynthetic processGO:19011372070.018
purine containing compound catabolic processGO:00725234110.018
anterior posterior axis specificationGO:000994820.018
retina vasculature development in camera type eyeGO:006129830.017
female gamete generationGO:000729220.017
response to lipidGO:00339932060.017
anion transmembrane transportGO:0098656760.017
jnk cascadeGO:0007254800.017
elastic fiber assemblyGO:004825130.017
cellular response to dna damage stimulusGO:00069743790.017
cellular homeostasisGO:00197251960.017
organophosphate catabolic processGO:00464344300.017
posttranscriptional regulation of gene expressionGO:00106082130.017
regulation of map kinase activityGO:00434051080.017
epithelial cell morphogenesisGO:000338280.017
secretionGO:00469032540.017
amine metabolic processGO:0009308440.017
growthGO:00400072020.017
negative regulation of cell differentiationGO:00455961710.017
cell matrix adhesionGO:0007160850.017
regulation of protein localizationGO:00328802960.017
neuromuscular junction developmentGO:000752830.016
regulation of ras protein signal transductionGO:00465781550.016
purine ribonucleoside triphosphate catabolic processGO:00092073910.016
cellular response to cytokine stimulusGO:00713451810.016
negative regulation of immune system processGO:00026831360.016
positive regulation of hemostasisGO:1900048110.016
regulation of stress activated protein kinase signaling cascadeGO:0070302850.016
endochondral bone morphogenesisGO:006035030.016
response to transforming growth factor betaGO:0071559940.016
ribonucleoside catabolic processGO:00424544060.016
ribonucleotide catabolic processGO:00092614050.016
cellular response to fibroblast growth factor stimulusGO:0044344390.016
hindbrain developmentGO:003090230.016
myeloid leukocyte activationGO:0002274340.016
regulation of establishment of protein localizationGO:00702012420.016
positive regulation of nucleotide catabolic processGO:00308131850.016
regulation of cellular amino acid metabolic processGO:000652160.016
positive regulation of secretionGO:00510471160.016
collagen biosynthetic processGO:0032964150.016
rhythmic behaviorGO:000762220.016
axon regenerationGO:003110310.016
proteolysis involved in cellular protein catabolic processGO:00516032440.016
purine nucleotide catabolic processGO:00061954050.016
epithelial cell migrationGO:00106311190.016
reactive oxygen species metabolic processGO:0072593750.016
purine ribonucleoside catabolic processGO:00461303980.015
positive regulation of protein phosphorylationGO:00019343130.015
negative regulation of response to external stimulusGO:0032102830.015
canonical wnt signaling pathway involved in mesenchymal stem cell differentiationGO:004433820.015
lipid localizationGO:00108761060.015
negative regulation of phosphorus metabolic processGO:00105632670.015
positive regulation of cellular amine metabolic processGO:003324070.015
endoderm formationGO:0001706330.015
negative regulation of cell growthGO:0030308830.015
negative regulation of angiogenesisGO:0016525390.015
symbiosis encompassing mutualism through parasitismGO:00444031560.015
purine ribonucleoside metabolic processGO:00461284370.015
ribonucleoside triphosphate catabolic processGO:00092033910.015
i kappab kinase nf kappab signalingGO:00072491660.015
regulation of protein maturationGO:19033171500.015
positive regulation of response to external stimulusGO:0032103880.015
nucleoside phosphate catabolic processGO:19012924120.015
nucleoside catabolic processGO:00091644080.015
glycoprotein metabolic processGO:00091001100.015
behaviorGO:00076101120.014
organonitrogen compound biosynthetic processGO:19015662000.014
cellular response to organonitrogen compoundGO:00714171240.014
protein localization to organelleGO:00333652800.014
cell projection morphogenesisGO:00488581290.014
regulation of hormone levelsGO:00108171250.014
cerebellum developmentGO:002154920.014
tripartite regional subdivisionGO:000735120.014
anterior posterior axis specification embryoGO:000859520.014
glomerular visceral epithelial cell developmentGO:007201520.014
prostate gland developmentGO:003085030.014
small molecule biosynthetic processGO:00442831570.014
odontogenesisGO:0042476250.014
segmentationGO:003528240.014
positive regulation of catabolic processGO:00098963100.014
regulation of endopeptidase activityGO:00525481700.014
glycosaminoglycan metabolic processGO:0030203350.014
gtp metabolic processGO:00460392390.014
regulation of cellular ketone metabolic processGO:0010565500.014
negative regulation of fibroblast growth factor receptor signaling pathwayGO:004003720.014
single organism membrane organizationGO:00448022680.014
regulation of intracellular transportGO:00323861950.014
positive regulation of hydrolase activityGO:00513453310.013
interspecies interaction between organismsGO:00444191560.013
chronic inflammatory responseGO:000254420.013
cellular response to amino acid stimulusGO:0071230120.013
oogenesisGO:004847720.013
metencephalon developmentGO:002203720.013
glycerolipid metabolic processGO:00464861070.013
glycosyl compound catabolic processGO:19016584130.013
cellular lipid metabolic processGO:00442553030.013
negative regulation of immune effector processGO:0002698380.013
syncytium formation by plasma membrane fusionGO:000076820.013
purine nucleoside triphosphate metabolic processGO:00091444120.013
myoblast fusionGO:000752010.013
membrane organizationGO:00610242920.013
positive regulation of chemotaxisGO:0050921570.013
cellular amine metabolic processGO:0044106410.013
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238260.013
response to glucoseGO:0009749190.013
detection of stimulusGO:0051606850.013
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101450.013
negative regulation of endodermal cell differentiationGO:190322520.013
embryonic forelimb morphogenesisGO:003511540.013
cellular chemical homeostasisGO:00550821800.013
regulation of macrophage chemotaxisGO:001075840.013
tube developmentGO:00352951250.013
microtubule based processGO:00070172100.013
guanosine containing compound catabolic processGO:19010692390.013
regulation of cell growthGO:00015581350.013
cellular response to lipidGO:00713961270.013
positive regulation of cell activationGO:0050867810.013
cell chemotaxisGO:00603261120.013
canonical wnt signaling pathwayGO:00600701160.013
positive regulation of gtp catabolic processGO:00331261660.013
negative regulation of cell migrationGO:00303361020.013
mitotic cell cycleGO:00002783260.013
peripheral nervous system developmentGO:000742220.013
nucleoside triphosphate metabolic processGO:00091414220.013
cytoplasmic transportGO:00164823790.013
peptidyl tyrosine phosphorylationGO:00181081700.012
response to carbohydrateGO:0009743210.012
extrinsic apoptotic signaling pathwayGO:00971911190.012
regulation of cytoplasmic transportGO:19036491490.012
nucleoside triphosphate catabolic processGO:00091433940.012
canonical wnt signaling pathway involved in osteoblast differentiationGO:004433920.012
negative regulation of protein processingGO:00109551420.012
negative regulation of locomotionGO:00400131180.012
nervous system developmentGO:00073992930.012
lipid metabolic processGO:00066293810.012
cell activationGO:00017752130.012
actin filament based movementGO:0030048170.012
positive regulation of wnt signaling pathwayGO:0030177540.012
regulation of purine nucleotide metabolic processGO:19005422640.012
positive regulation of defense responseGO:0031349870.012
bone mineralizationGO:0030282340.012
regulation of ion transportGO:00432691890.012
sensory perceptionGO:00076001030.012
cellular macromolecular complex assemblyGO:00346223240.012
cellular response to glucocorticoid stimulusGO:007138540.012
engulfment of apoptotic cellGO:004365220.012
cellular response to growth factor stimulusGO:00713631970.012
oxidation reduction processGO:00551143960.012
branching involved in salivary gland morphogenesisGO:006044510.012
memoryGO:000761330.012
purine nucleoside triphosphate catabolic processGO:00091463920.012
positive regulation of cell adhesionGO:0045785840.012
regulation of leukocyte activationGO:00026941150.012
mesenchymal stem cell differentiationGO:007249780.012
negative regulation of apoptotic processGO:00430663160.012
regulation of body fluid levelsGO:0050878990.011
sulfur compound biosynthetic processGO:0044272380.011
positive regulation of nucleoside metabolic processGO:00459791860.011
regulation of phosphate transportGO:001096630.011
neurogenesisGO:00220081690.011
motor neuron axon guidanceGO:000804520.011
regulation of apoptotic signaling pathwayGO:20012331750.011
spermatid differentiationGO:004851540.011
response to hexoseGO:0009746200.011
guanosine containing compound metabolic processGO:19010682440.011
regulation of mesenchymal stem cell differentiationGO:200073960.011
positive regulation of purine nucleotide metabolic processGO:19005442270.011
single organism carbohydrate metabolic processGO:00447231930.011
immune response activating signal transductionGO:0002757900.011
ribonucleoside triphosphate metabolic processGO:00091994120.011
hemostasisGO:0007599760.011
head developmentGO:00603221080.011
cartilage development involved in endochondral bone morphogenesisGO:006035120.011
sprouting angiogenesisGO:0002040290.011
regulation of growthGO:00400081650.011
positive regulation of apoptotic signaling pathwayGO:2001235700.011
negative regulation of cellular amino acid metabolic processGO:004576320.011
positive regulation of leukocyte activationGO:0002696800.011
positive regulation of cellular component biogenesisGO:00440891580.011
nuclear transportGO:00511691790.011
epithelial to mesenchymal transitionGO:0001837480.011
protein localization to nucleusGO:00345041360.011
regulation of nucleoside metabolic processGO:00091182090.011
fatty acid metabolic processGO:00066311150.011
activation of protein kinase activityGO:0032147900.011
negative regulation of transmembrane transportGO:0034763290.011
eye developmentGO:0001654420.011
retina vasculature morphogenesis in camera type eyeGO:006129930.011
translationGO:00064121320.011
regulation of stress activated mapk cascadeGO:0032872840.011
covalent chromatin modificationGO:00165692540.011
single organism cellular localizationGO:19025803320.011
negative regulation of response to woundingGO:1903035470.011
protein trimerizationGO:0070206200.011
protein secretionGO:0009306980.011
cytokine mediated signaling pathwayGO:00192211090.011
histone modificationGO:00165702510.011
multicellular organismal response to stressGO:003355510.011
tissue regenerationGO:004224630.011
cellular response to oxygen containing compoundGO:19017012760.011
regulation of cellular component biogenesisGO:00440872810.011
interleukin 8 productionGO:0032637510.010
negative regulation of programmed cell deathGO:00430693210.010
regulation of gtp catabolic processGO:00331241800.010
regulation of multi organism processGO:00439001570.010
negative regulation of peptidase activityGO:0010466910.010
chemical homeostasisGO:00488783060.010
cerebral cortex developmentGO:0021987100.010
regulation of small gtpase mediated signal transductionGO:00510561560.010
cellular response to extracellular stimulusGO:0031668720.010
negative regulation of cell motilityGO:20001461040.010
embryonic skeletal joint developmentGO:007249820.010
regulation of cell cycleGO:00517263930.010
regulation of sodium dependent phosphate transportGO:200011820.010
positive regulation of stem cell proliferationGO:2000648100.010
regulation of vesicle mediated transportGO:00606271300.010
purine ribonucleoside triphosphate metabolic processGO:00092054110.010
spermatid developmentGO:000728640.010
positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathwayGO:003579320.010
cell fate determinationGO:000170930.010
regulation of meiotic cell cycleGO:005144540.010
ion homeostasisGO:00508012300.010

PCOLCE disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.552
connective tissue diseaseDOID:651090.506
bone diseaseDOID:0080001880.257
bone development diseaseDOID:0080006550.257
muscle tissue diseaseDOID:661130.115
congenital muscular dystrophyDOID:0050557220.115
muscular dystrophyDOID:9884510.115
muscular diseaseDOID:00800001140.115
myopathyDOID:4231040.115
eye and adnexa diseaseDOID:14921500.101
sensory system diseaseDOID:00501552030.101
nervous system diseaseDOID:8634310.101
osteogenesis imperfectaDOID:12347130.097
osteochondrodysplasiaDOID:2256350.097
urinary system diseaseDOID:18400.040
eye diseaseDOID:56141490.029
disease of metabolismDOID:00146672950.018
collagen diseaseDOID:85490.018
retinal degenerationDOID:8466890.017
retinal diseaseDOID:56791180.017
ehlers danlos syndromeDOID:1335990.013
neurodegenerative diseaseDOID:12891020.010
central nervous system diseaseDOID:3311860.010