IMP: Integrative Multi-species Prediction

Homo sapiens

27 known processes

PRKAG1

protein kinase, AMP-activated, gamma 1 non-catalytic subunit

(Aliases: MGC8666,AMPKG)

HGNC: 9385
MIM: 602742
HPRD: 04118
Entrez: 5571
Ensembl: ENSG00000181929
UniProtKB: F8VYY9
UniProtKB: A0A024R125
UniProtKB: P54619

Process Predictions
Disease Predictions

PRKAG1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
establishment or maintenance of epithelial cell apical basal polarity	GO:0045197	1	0.505
establishment or maintenance of apical basal cell polarity	GO:0035088	2	0.442
oxidation reduction process	GO:0055114	396	0.419	Human
positive regulation of gluconeogenesis	GO:0045722	1	0.392	Yeast
multicellular organismal aging	GO:0010259	3	0.210
hexose metabolic process	GO:0019318	55	0.195	Yeast
establishment or maintenance of bipolar cell polarity	GO:0061245	2	0.194
regulation of cellular ketone metabolic process	GO:0010565	50	0.185	Human Yeast
positive regulation of meiotic cell cycle	GO:0051446	2	0.171
histone serine phosphorylation	GO:0035404	4	0.165
determination of adult lifespan	GO:0008340	2	0.160
biological adhesion	GO:0022610	331	0.153
cellular lipid metabolic process	GO:0044255	303	0.152	Human
cell adhesion	GO:0007155	325	0.151
positive regulation of glycolytic process	GO:0045821	4	0.145
regulation of carbohydrate metabolic process	GO:0006109	54	0.145	Human Yeast
regulation of tor signaling	GO:0032006	30	0.144
negative regulation of apoptotic process	GO:0043066	316	0.134
histone modification	GO:0016570	251	0.131
carbohydrate metabolic process	GO:0005975	207	0.130	Human Yeast
carbohydrate catabolic process	GO:0016052	36	0.129	Human
cellular ketone metabolic process	GO:0042180	80	0.128	Human Yeast
purine ribonucleoside metabolic process	GO:0046128	437	0.127
regulation of meiotic cell cycle	GO:0051445	4	0.123
negative regulation of protein metabolic process	GO:0051248	391	0.122	Human
regulation of lipid metabolic process	GO:0019216	96	0.121	Human
ribonucleoside monophosphate metabolic process	GO:0009161	187	0.120
ion homeostasis	GO:0050801	230	0.111
regulation of cellular component biogenesis	GO:0044087	281	0.107
protein maturation	GO:0051604	233	0.106
cytoplasmic transport	GO:0016482	379	0.104
cellular response to nutrient levels	GO:0031669	69	0.101
carbohydrate transport	GO:0008643	37	0.100
purine nucleoside monophosphate metabolic process	GO:0009126	186	0.097
protein autophosphorylation	GO:0046777	123	0.095
positive regulation of carbohydrate metabolic process	GO:0045913	21	0.090	Yeast
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.090
regulation of energy homeostasis	GO:2000505	1	0.088
response to oxygen containing compound	GO:1901700	369	0.085
monocarboxylic acid metabolic process	GO:0032787	185	0.085	Human
cellular response to oxygen containing compound	GO:1901701	276	0.083
positive regulation of glucose metabolic process	GO:0010907	12	0.082	Yeast
negative regulation of lipid catabolic process	GO:0050995	9	0.082
monosaccharide metabolic process	GO:0005996	74	0.080	Yeast
regulation of glucose import	GO:0046324	21	0.080
response to reactive oxygen species	GO:0000302	61	0.079
multicellular organismal homeostasis	GO:0048871	67	0.076
regulation of protein complex assembly	GO:0043254	147	0.076
negative regulation of transport	GO:0051051	176	0.075
negative regulation of cell cycle	GO:0045786	193	0.074
cellular response to reactive oxygen species	GO:0034614	50	0.073
cell growth	GO:0016049	160	0.073
negative regulation of cellular protein metabolic process	GO:0032269	353	0.071	Human
peptidyl serine modification	GO:0018209	106	0.071
posttranscriptional regulation of gene expression	GO:0010608	213	0.071
protein localization to organelle	GO:0033365	280	0.068
post embryonic development	GO:0009791	2	0.067
cellular carbohydrate catabolic process	GO:0044275	17	0.065	Human
cellular response to hydrogen peroxide	GO:0070301	37	0.064
sequestering of triglyceride	GO:0030730	11	0.064
cellular macromolecule catabolic process	GO:0044265	380	0.064
lipid biosynthetic process	GO:0008610	177	0.064
response to caffeine	GO:0031000	3	0.062
regulation of mitotic cell cycle	GO:0007346	189	0.060
positive regulation of cellular catabolic process	GO:0031331	284	0.060
negative regulation of intracellular signal transduction	GO:1902532	183	0.058
lipid modification	GO:0030258	84	0.058
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.056
peptidyl tyrosine modification	GO:0018212	170	0.056
carbohydrate biosynthetic process	GO:0016051	42	0.056	Yeast
response to nutrient levels	GO:0031667	81	0.054
lipid metabolic process	GO:0006629	381	0.054	Human
regulation of cellular carbohydrate metabolic process	GO:0010675	47	0.053	Human Yeast
positive regulation of response to external stimulus	GO:0032103	88	0.053
chemical homeostasis	GO:0048878	306	0.052
nucleoside monophosphate metabolic process	GO:0009123	191	0.050
regulation of cell growth	GO:0001558	135	0.049
single organism cellular localization	GO:1902580	332	0.049
positive regulation of autophagy	GO:0010508	24	0.048
purine containing compound catabolic process	GO:0072523	411	0.048
growth	GO:0040007	202	0.048
histone phosphorylation	GO:0016572	16	0.047
cellular response to starvation	GO:0009267	58	0.047
nucleoside phosphate catabolic process	GO:1901292	412	0.047
intracellular protein transport	GO:0006886	270	0.046
lipid oxidation	GO:0034440	33	0.046
positive regulation of protein phosphorylation	GO:0001934	313	0.045	Human Yeast
positive regulation of phosphorylation	GO:0042327	394	0.045	Human Yeast
mitotic cell cycle	GO:0000278	326	0.044
single organism membrane organization	GO:0044802	268	0.043
protein heterooligomerization	GO:0051291	16	0.042	Rat
transmembrane transport	GO:0055085	399	0.042
purine ribonucleoside monophosphate metabolic process	GO:0009167	186	0.041
positive regulation of catabolic process	GO:0009896	310	0.041
peptidyl tyrosine phosphorylation	GO:0018108	170	0.041
vesicle mediated transport	GO:0016192	371	0.040
nucleoside triphosphate metabolic process	GO:0009141	422	0.040
negative regulation of phosphate metabolic process	GO:0045936	267	0.040	Human
nucleotide catabolic process	GO:0009166	408	0.039
regulation of response to external stimulus	GO:0032101	222	0.039
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.038
regulation of cellular carbohydrate catabolic process	GO:0043471	11	0.038	Human
digestive system process	GO:0022600	17	0.038
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.038
response to nitrogen compound	GO:1901698	184	0.038
establishment of protein localization to membrane	GO:0090150	121	0.037
peptidyl serine phosphorylation	GO:0018105	101	0.037
membrane organization	GO:0061024	292	0.037
oogenesis	GO:0048477	2	0.036
translation	GO:0006412	132	0.036
divalent metal ion transport	GO:0070838	152	0.036
regulation of protein kinase activity	GO:0045859	289	0.036	Human Yeast
female gamete generation	GO:0007292	2	0.034
system process	GO:0003008	349	0.034
lens development in camera type eye	GO:0002088	2	0.034
guanosine containing compound metabolic process	GO:1901068	244	0.034
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.033
regulation of carbohydrate biosynthetic process	GO:0043255	27	0.033	Yeast
lipid localization	GO:0010876	106	0.032
protein targeting	GO:0006605	187	0.032
fatty acid oxidation	GO:0019395	31	0.031
glucose import in response to insulin stimulus	GO:0044381	4	0.031
negative regulation of catalytic activity	GO:0043086	335	0.030	Human
neuromuscular junction development	GO:0007528	3	0.030
protein localization to membrane	GO:0072657	160	0.030
protein modification by small protein removal	GO:0070646	92	0.030
cellular response to oxidative stress	GO:0034599	85	0.030
chromatin organization	GO:0006325	351	0.030
cellular amine metabolic process	GO:0044106	41	0.029
locomotory behavior	GO:0007626	1	0.029
purine nucleotide catabolic process	GO:0006195	405	0.029
covalent chromatin modification	GO:0016569	254	0.028
digestion	GO:0007586	22	0.028
organophosphate catabolic process	GO:0046434	430	0.028
regulation of kinase activity	GO:0043549	314	0.028	Human Yeast
positive regulation of hydrolase activity	GO:0051345	331	0.028
response to hydrogen peroxide	GO:0042542	40	0.027
regulation of cell cycle process	GO:0010564	266	0.027
response to decreased oxygen levels	GO:0036293	96	0.027
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.027
autophagy	GO:0006914	88	0.027
cell morphogenesis	GO:0000902	296	0.027
cellular response to nitrogen compound	GO:1901699	144	0.027
cellular macromolecular complex assembly	GO:0034622	324	0.027
receptor mediated endocytosis	GO:0006898	84	0.026
hexose biosynthetic process	GO:0019319	9	0.026	Yeast
oocyte differentiation	GO:0009994	2	0.026
small gtpase mediated signal transduction	GO:0007264	78	0.026
response to starvation	GO:0042594	59	0.026
energy derivation by oxidation of organic compounds	GO:0015980	43	0.026	Human
regulation of growth	GO:0040008	165	0.025
double strand break repair	GO:0006302	101	0.025
secretion by cell	GO:0032940	226	0.025
cellular response to organonitrogen compound	GO:0071417	124	0.025
oocyte development	GO:0048599	1	0.025
anion homeostasis	GO:0055081	18	0.025
positive regulation of cell proliferation	GO:0008284	301	0.025
response to radiation	GO:0009314	151	0.024
glycosyl compound catabolic process	GO:1901658	413	0.024
regulation of nucleotide metabolic process	GO:0006140	269	0.024
endocytosis	GO:0006897	159	0.024
amine metabolic process	GO:0009308	44	0.024
chromatin modification	GO:0016568	298	0.024
negative regulation of protein processing	GO:0010955	142	0.023
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	131	0.023
response to organonitrogen compound	GO:0010243	156	0.023
cellular response to dna damage stimulus	GO:0006974	379	0.023
intracellular protein transmembrane transport	GO:0065002	24	0.022
negative regulation of mitotic cell cycle	GO:0045930	102	0.022
tor signaling	GO:0031929	39	0.022
cellular component morphogenesis	GO:0032989	314	0.022
response to ionizing radiation	GO:0010212	65	0.022
negative regulation of protein phosphorylation	GO:0001933	140	0.022	Human
regulation of establishment of protein localization	GO:0070201	242	0.022
positive regulation of nucleoside metabolic process	GO:0045979	186	0.022
glycolytic process	GO:0006096	17	0.022	Human
cation transport	GO:0006812	331	0.022
negative regulation of cell proliferation	GO:0008285	228	0.022
immune response	GO:0006955	307	0.021
regulation of cellular amino acid metabolic process	GO:0006521	6	0.021
regulation of cell cycle	GO:0051726	393	0.021
response to other organism	GO:0051707	261	0.021
response to oxidative stress	GO:0006979	121	0.021
defense response	GO:0006952	315	0.021
regulation of transferase activity	GO:0051338	355	0.021	Human Yeast
single organism carbohydrate metabolic process	GO:0044723	193	0.020	Human Yeast
positive regulation of apoptotic process	GO:0043065	246	0.020
regulation of nucleoside metabolic process	GO:0009118	209	0.020
regulation of glucose metabolic process	GO:0010906	28	0.020	Yeast
cellular response to external stimulus	GO:0071496	111	0.020
regulation of gtpase activity	GO:0043087	180	0.020
regulation of protein localization	GO:0032880	296	0.020
energy homeostasis	GO:0097009	3	0.020
cellular response to alcohol	GO:0097306	29	0.020
neurotransmitter secretion	GO:0007269	4	0.019
positive regulation of purine nucleotide metabolic process	GO:1900544	227	0.019
negative regulation of tor signaling	GO:0032007	11	0.019
ribonucleotide catabolic process	GO:0009261	405	0.019
establishment of protein localization to organelle	GO:0072594	172	0.019
response to external biotic stimulus	GO:0043207	261	0.019
negative regulation of lipid metabolic process	GO:0045833	38	0.019
positive regulation of developmental process	GO:0051094	314	0.018
regulation of intracellular protein transport	GO:0033157	123	0.018
protein modification by small protein conjugation	GO:0032446	342	0.018
positive regulation of cellular amine metabolic process	GO:0033240	7	0.018
calcium ion transport	GO:0006816	147	0.018
regulation of dna metabolic process	GO:0051052	153	0.018
cation transmembrane transport	GO:0098655	238	0.017
maintenance of location	GO:0051235	112	0.017
response to light stimulus	GO:0009416	87	0.017
positive regulation of kinase activity	GO:0033674	204	0.017	Human Yeast
intracellular protein transmembrane import	GO:0044743	23	0.017
aging	GO:0007568	66	0.017	Yeast
regulation of protein processing	GO:0070613	150	0.017
regulation of protein maturation	GO:1903317	150	0.017
positive regulation of protein kinase activity	GO:0045860	190	0.017	Human Yeast
response to extracellular stimulus	GO:0009991	85	0.017
gmp metabolic process	GO:0046037	4	0.017
cell cycle phase transition	GO:0044770	173	0.017
endosomal transport	GO:0016197	129	0.017
actin mediated cell contraction	GO:0070252	12	0.017
regulation of cellular response to stress	GO:0080135	244	0.017
regulation of protein serine threonine kinase activity	GO:0071900	179	0.017	Human Yeast
neurogenesis	GO:0022008	169	0.017
positive regulation of nucleotide metabolic process	GO:0045981	230	0.016
taxis	GO:0042330	157	0.016
protein deubiquitination	GO:0016579	79	0.016
negative regulation of cell size	GO:0045792	3	0.016
actin filament based process	GO:0030029	224	0.016
regulation of digestive system process	GO:0044058	5	0.016
regulation of cysteine type endopeptidase activity	GO:2000116	127	0.016
negative regulation of protein transport	GO:0051224	75	0.016
positive regulation of transport	GO:0051050	336	0.016
cell part morphogenesis	GO:0032990	137	0.016
response to uv	GO:0009411	73	0.016
regulation of ras protein signal transduction	GO:0046578	155	0.016
response to alcohol	GO:0097305	64	0.016
regeneration	GO:0031099	4	0.016
response to abiotic stimulus	GO:0009628	336	0.016
chemotaxis	GO:0006935	157	0.016
dna catabolic process	GO:0006308	49	0.015
ribonucleoside catabolic process	GO:0042454	406	0.015
regulation of nucleotide catabolic process	GO:0030811	205	0.015
cellular metal ion homeostasis	GO:0006875	146	0.015
reactive nitrogen species metabolic process	GO:2001057	3	0.015
associative learning	GO:0008306	1	0.015
response to wounding	GO:0009611	168	0.015
motor neuron axon guidance	GO:0008045	2	0.015
nucleoside triphosphate catabolic process	GO:0009143	394	0.015
purine ribonucleoside catabolic process	GO:0046130	398	0.015
regulation of cellular amine metabolic process	GO:0033238	11	0.015
interspecies interaction between organisms	GO:0044419	156	0.015
monosaccharide biosynthetic process	GO:0046364	10	0.015	Yeast
positive regulation of response to extracellular stimulus	GO:0032106	14	0.015
regulation of purine nucleotide metabolic process	GO:1900542	264	0.015
metal ion transport	GO:0030001	272	0.015
response to organic cyclic compound	GO:0014070	204	0.015
cardiac muscle cell contraction	GO:0086003	4	0.015
negative regulation of protein modification process	GO:0031400	200	0.015	Human
atp metabolic process	GO:0046034	176	0.014
regulation of intracellular transport	GO:0032386	195	0.014
alpha amino acid metabolic process	GO:1901605	72	0.014
mitotic cell cycle phase transition	GO:0044772	162	0.014
negative regulation of hydrolase activity	GO:0051346	182	0.014
regulation of glucose transport	GO:0010827	23	0.014
negative regulation of protein kinase activity	GO:0006469	98	0.014	Human
nadph oxidation	GO:0070995	3	0.014
positive regulation of dna metabolic process	GO:0051054	73	0.014
secretion	GO:0046903	254	0.014
regulation of mitotic cell cycle phase transition	GO:1901990	118	0.014
toxin transport	GO:1901998	4	0.014
positive regulation of programmed cell death	GO:0043068	249	0.014
regulation of anatomical structure morphogenesis	GO:0022603	286	0.014
regulation of small gtpase mediated signal transduction	GO:0051056	156	0.014
protein catabolic process	GO:0030163	325	0.014
regulation of endopeptidase activity	GO:0052548	170	0.014
positive regulation of purine nucleotide catabolic process	GO:0033123	185	0.014
blastoderm segmentation	GO:0007350	2	0.013
cellular ion homeostasis	GO:0006873	168	0.013
organic acid biosynthetic process	GO:0016053	97	0.013
mitochondrial transport	GO:0006839	60	0.013
monosaccharide transport	GO:0015749	32	0.013
regulation of reactive oxygen species metabolic process	GO:2000377	41	0.013
regulation of immune response	GO:0050776	201	0.013
sensory perception of pain	GO:0019233	4	0.013
purine nucleoside catabolic process	GO:0006152	398	0.013
cellular amino acid metabolic process	GO:0006520	116	0.013
negative regulation of catabolic process	GO:0009895	104	0.013
protein processing	GO:0016485	226	0.013
ubiquitin dependent protein catabolic process	GO:0006511	206	0.013
cell aging	GO:0007569	52	0.013	Yeast
regulation of protein catabolic process	GO:0042176	155	0.013
negative regulation of epithelial cell proliferation	GO:0050680	48	0.013
negative regulation of proteolysis	GO:0045861	132	0.013
cellular response to oxygen levels	GO:0071453	55	0.013
golgi vesicle transport	GO:0048193	80	0.013
positive regulation of cellular component organization	GO:0051130	376	0.013
negative regulation of cell death	GO:0060548	345	0.013
negative regulation of protein maturation	GO:1903318	142	0.013
negative regulation of programmed cell death	GO:0043069	321	0.013
negative regulation of cellular amino acid metabolic process	GO:0045763	2	0.013
positive regulation of gtpase activity	GO:0043547	166	0.013
cellular response to extracellular stimulus	GO:0031668	72	0.013
cell projection organization	GO:0030030	252	0.013
modification dependent macromolecule catabolic process	GO:0043632	212	0.013
regulation of peptidase activity	GO:0052547	180	0.013
response to biotic stimulus	GO:0009607	276	0.013
cell development	GO:0048468	328	0.012
establishment or maintenance of cell polarity	GO:0007163	31	0.012
response to hypoxia	GO:0001666	96	0.012
small molecule biosynthetic process	GO:0044283	157	0.012
protein ubiquitination	GO:0016567	314	0.012
negative regulation of cellular amine metabolic process	GO:0033239	3	0.012
viral process	GO:0016032	146	0.012
cellular response to hormone stimulus	GO:0032870	125	0.012
protein import	GO:0017038	130	0.012
cell morphogenesis involved in differentiation	GO:0000904	144	0.012
response to gamma radiation	GO:0010332	14	0.012
carboxylic acid biosynthetic process	GO:0046394	97	0.012
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.012
nuclear transport	GO:0051169	179	0.012
regulation of sequence specific dna binding transcription factor activity	GO:0051090	211	0.012
regulation of reactive oxygen species biosynthetic process	GO:1903426	3	0.012
canonical wnt signaling pathway	GO:0060070	116	0.012
regulation of gtp catabolic process	GO:0033124	180	0.012
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	116	0.012
regulation of protein modification by small protein conjugation or removal	GO:1903320	107	0.012
positive regulation of reactive oxygen species metabolic process	GO:2000379	24	0.012
multi organism cellular process	GO:0044764	156	0.012
peripheral nervous system development	GO:0007422	2	0.012
mitotic cell cycle process	GO:1903047	286	0.012
defense response to other organism	GO:0098542	129	0.011
carbohydrate homeostasis	GO:0033500	31	0.011
adult locomotory behavior	GO:0008344	1	0.011
regulation of protein transport	GO:0051223	213	0.011
neurological system process	GO:0050877	163	0.011
positive regulation of cell death	GO:0010942	263	0.011
regulation of viral process	GO:0050792	103	0.011
mitochondrial membrane organization	GO:0007006	40	0.011
cell activation	GO:0001775	213	0.011
regulation of cell cycle phase transition	GO:1901987	126	0.011
neuron differentiation	GO:0030182	138	0.011
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	109	0.011
regulation of response to dna damage stimulus	GO:2001020	94	0.011
rna interference	GO:0016246	4	0.011
viral life cycle	GO:0019058	132	0.011
negative regulation of protein catabolic process	GO:0042177	59	0.011
regulation of calcium ion transport	GO:0051924	79	0.011
response to axon injury	GO:0048678	1	0.011
divalent inorganic cation homeostasis	GO:0072507	136	0.011
purine ribonucleotide catabolic process	GO:0009154	404	0.011
regulation of protein stability	GO:0031647	87	0.011
regulation of membrane potential	GO:0042391	95	0.011
cellular response to peptide	GO:1901653	59	0.011
response to virus	GO:0009615	126	0.011
protein transmembrane transport	GO:0071806	25	0.011
tricarboxylic acid metabolic process	GO:0072350	4	0.011
response to cytokine	GO:0034097	232	0.011
cellular protein catabolic process	GO:0044257	261	0.011
apoptotic signaling pathway	GO:0097190	268	0.011
regulation of carbohydrate catabolic process	GO:0043470	11	0.011	Human
regulation of cytoplasmic transport	GO:1903649	149	0.011
visual behavior	GO:0007632	2	0.010
rhythmic behavior	GO:0007622	2	0.010
negative regulation of protein serine threonine kinase activity	GO:0071901	57	0.010	Human
reactive oxygen species metabolic process	GO:0072593	75	0.010
epithelial cell proliferation	GO:0050673	128	0.010
negative regulation of axonogenesis	GO:0050771	4	0.010
calcium ion homeostasis	GO:0055074	122	0.010
proteasomal protein catabolic process	GO:0010498	176	0.010
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	91	0.010
histone h3 acetylation	GO:0043966	45	0.010
visual learning	GO:0008542	1	0.010
positive regulation of protein transport	GO:0051222	135	0.010
cellular divalent inorganic cation homeostasis	GO:0072503	128	0.010
reactive oxygen species biosynthetic process	GO:1903409	4	0.010

PRKAG1 disease predictions

Disease	DO term ID	Size	Probability	Func Analog Org
disease of metabolism	DOID:0014667	295	0.032
cardiovascular system disease	DOID:1287	106	0.031	Human
musculoskeletal system disease	DOID:17	223	0.031	Human
cardiomyopathy	DOID:0050700	50	0.031	Human
muscular disease	DOID:0080000	114	0.031	Human
muscle tissue disease	DOID:66	113	0.031	Human
myopathy	DOID:423	104	0.031	Human
heart disease	DOID:114	68	0.031	Human
nervous system disease	DOID:863	431	0.021
eye and adnexa disease	DOID:1492	150	0.021
sensory system disease	DOID:0050155	203	0.021
cancer	DOID:162	167	0.017
disease of cellular proliferation	DOID:14566	174	0.017
eye disease	DOID:5614	149	0.016
organ system cancer	DOID:0050686	164	0.014
retinal disease	DOID:5679	118	0.014
immune system disease	DOID:2914	155	0.012
endocrine gland cancer	DOID:170	26	0.011

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