Homo sapiens

40 known processes

PCSK6

proprotein convertase subtilisin/kexin type 6

(Aliases: SPC4,PACE4)

PCSK6 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amino acid metabolic processGO:00065201160.159
cellular amine metabolic processGO:0044106410.079
cellular ketone metabolic processGO:0042180800.076
post embryonic developmentGO:000979120.074
lipid metabolic processGO:00066293810.073
cellular lipid metabolic processGO:00442553030.073
regulation of cell differentiationGO:00455953930.071
negative regulation of cell proliferationGO:00082852280.070
cell adhesionGO:00071553250.070
regulation of cellular amine metabolic processGO:0033238110.069
amine metabolic processGO:0009308440.067
ras protein signal transductionGO:0007265730.066
purine ribonucleoside triphosphate catabolic processGO:00092073910.064
regulation of anatomical structure morphogenesisGO:00226032860.063
negative regulation of multicellular organismal processGO:00512413170.063
organophosphate catabolic processGO:00464344300.059
organic hydroxy compound metabolic processGO:19016151470.059
anion transportGO:00068201610.059
biological adhesionGO:00226103310.058
protein processingGO:00164852260.058
regulation of cellular ketone metabolic processGO:0010565500.057
chemical homeostasisGO:00488783060.057
regulation of cellular amino acid metabolic processGO:000652160.055
cellular response to endogenous stimulusGO:00714953360.054
positive regulation of hydrolase activityGO:00513453310.054
small gtpase mediated signal transductionGO:0007264780.053
positive regulation of cellular component organizationGO:00511303760.052
anatomical structure formation involved in morphogenesisGO:00486462840.052
regulation of locomotionGO:00400123290.052
protein maturationGO:00516042330.052
system processGO:00030083490.052
Human
purine containing compound catabolic processGO:00725234110.052
regulation of cell motilityGO:20001452990.051
purine ribonucleoside metabolic processGO:00461284370.051
response to oxygen containing compoundGO:19017003690.050
ion transmembrane transportGO:00342203380.050
glycosyl compound catabolic processGO:19016584130.049
secretionGO:00469032540.049
lipid biosynthetic processGO:00086101770.049
regulation of cell migrationGO:00303342890.049
ribonucleoside triphosphate metabolic processGO:00091994120.049
purine ribonucleoside catabolic processGO:00461303980.048
negative regulation of protein metabolic processGO:00512483910.047
positive regulation of cellular amino acid metabolic processGO:004576430.047
regulation of cellular component biogenesisGO:00440872810.047
cellular component morphogenesisGO:00329893140.047
nucleotide catabolic processGO:00091664080.046
cellular response to oxygen containing compoundGO:19017012760.046
secretion by cellGO:00329402260.046
ribonucleotide catabolic processGO:00092614050.046
regulation of hormone levelsGO:00108171250.046
nervous system developmentGO:00073992930.046
cell developmentGO:00484683280.046
carbohydrate metabolic processGO:00059752070.045
nucleoside catabolic processGO:00091644080.045
transmembrane transportGO:00550853990.045
nucleoside phosphate catabolic processGO:19012924120.045
ribonucleoside catabolic processGO:00424544060.045
purine ribonucleoside triphosphate metabolic processGO:00092054110.045
regulation of cellular component movementGO:00512703340.045
organic anion transportGO:00157111030.045
purine nucleoside triphosphate metabolic processGO:00091444120.044
actin filament based processGO:00300292240.044
cation transportGO:00068123310.044
positive regulation of cellular amine metabolic processGO:003324070.044
single organism carbohydrate metabolic processGO:00447231930.044
positive regulation of transportGO:00510503360.044
nucleoside triphosphate metabolic processGO:00091414220.043
vesicle mediated transportGO:00161923710.043
positive regulation of phosphorylationGO:00423273940.043
single organism membrane organizationGO:00448022680.043
regulation of proteolysisGO:00301622930.043
ion homeostasisGO:00508012300.042
negative regulation of cellular component organizationGO:00511292350.042
locomotory behaviorGO:000762610.041
purine nucleoside catabolic processGO:00061523980.041
membrane organizationGO:00610242920.041
purine nucleotide catabolic processGO:00061954050.041
cell morphogenesisGO:00009022960.041
cytoplasmic transportGO:00164823790.041
positive regulation of catabolic processGO:00098963100.040
negative regulation of programmed cell deathGO:00430693210.040
multicellular organismal agingGO:001025930.039
purine nucleoside triphosphate catabolic processGO:00091463920.039
determination of adult lifespanGO:000834020.039
organic acid biosynthetic processGO:0016053970.039
negative regulation of cellular protein metabolic processGO:00322693530.039
negative regulation of cell deathGO:00605483450.038
nucleoside triphosphate catabolic processGO:00091433940.038
rho protein signal transductionGO:0007266260.038
cell projection organizationGO:00300302520.038
single organism cellular localizationGO:19025803320.037
female gamete generationGO:000729220.037
regulation of secretionGO:00510461940.037
cellular chemical homeostasisGO:00550821800.037
oxidation reduction processGO:00551143960.037
purine ribonucleotide catabolic processGO:00091544040.037
carboxylic acid biosynthetic processGO:0046394970.037
circulatory system developmentGO:00723592620.036
enzyme linked receptor protein signaling pathwayGO:00071673030.036
negative regulation of apoptotic processGO:00430663160.036
monocarboxylic acid metabolic processGO:00327871850.035
positive regulation of cellular catabolic processGO:00313312840.035
negative regulation of catalytic activityGO:00430863350.035
neuromuscular junction developmentGO:000752830.034
ribonucleoside triphosphate catabolic processGO:00092033910.034
regulation of kinase activityGO:00435493140.034
small molecule biosynthetic processGO:00442831570.033
oogenesisGO:004847720.033
cation homeostasisGO:00550801890.033
regulation of protein localizationGO:00328802960.033
regenerationGO:003109940.033
epithelium developmentGO:00604292270.032
regulation of transferase activityGO:00513383550.032
defense responseGO:00069523150.032
regulation of nucleotide metabolic processGO:00061402690.032
organonitrogen compound biosynthetic processGO:19015662000.032
Human
response to nitrogen compoundGO:19016981840.031
regulation of nucleotide catabolic processGO:00308112050.030
response to woundingGO:00096111680.030
positive regulation of cell proliferationGO:00082843010.030
immune responseGO:00069553070.030
growthGO:00400072020.030
regulation of protein maturationGO:19033171500.030
response to abiotic stimulusGO:00096283360.030
regulation of cell adhesionGO:00301551660.029
regulation of cytokine productionGO:00018172320.029
regulation of establishment of protein localizationGO:00702012420.029
cellular homeostasisGO:00197251960.029
cytokine productionGO:00018162470.029
positive regulation of purine nucleotide metabolic processGO:19005442270.029
regulation of protein processingGO:00706131500.029
protein catabolic processGO:00301633250.029
regulation of protein transportGO:00512232130.029
guanosine containing compound metabolic processGO:19010682440.028
negative regulation of protein maturationGO:19033181420.028
positive regulation of protein phosphorylationGO:00019343130.028
regulation of purine nucleotide metabolic processGO:19005422640.028
nitrogen compound transportGO:00717051910.028
negative regulation of developmental processGO:00510932470.028
neurogenesisGO:00220081690.028
regulation of secretion by cellGO:19035301770.028
gtp metabolic processGO:00460392390.028
regulation of protein kinase activityGO:00458592890.028
positive regulation of nucleoside metabolic processGO:00459791860.027
regulation of endopeptidase activityGO:00525481700.027
negative regulation of hydrolase activityGO:00513461820.027
negative regulation of protein processingGO:00109551420.027
positive regulation of nucleotide catabolic processGO:00308131850.027
regulation of response to external stimulusGO:00321012220.027
positive regulation of purine nucleotide catabolic processGO:00331231850.027
apoptotic signaling pathwayGO:00971902680.027
actin cytoskeleton organizationGO:00300362070.026
guanosine containing compound catabolic processGO:19010692390.026
memoryGO:000761330.026
regulation of purine nucleotide catabolic processGO:00331212050.026
cellular ion homeostasisGO:00068731680.026
positive regulation of programmed cell deathGO:00430682490.026
gtp catabolic processGO:00061842370.026
ameboidal type cell migrationGO:00016671350.026
negative regulation of phosphate metabolic processGO:00459362670.026
response to organic cyclic compoundGO:00140702040.025
cardiac muscle cell contractionGO:008600340.025
negative regulation of phosphorus metabolic processGO:00105632670.025
dephosphorylationGO:00163112090.025
cardiovascular system developmentGO:00723582620.025
regulation of nucleoside metabolic processGO:00091182090.025
response to biotic stimulusGO:00096072760.025
positive regulation of ras gtpase activityGO:00323201170.024
cellular macromolecule catabolic processGO:00442653800.024
positive regulation of nucleotide metabolic processGO:00459812300.024
intracellular protein transportGO:00068862700.024
metal ion transportGO:00300012720.024
adult locomotory behaviorGO:000834410.024
regulation of peptidase activityGO:00525471800.024
response to cytokineGO:00340972320.024
regulation of cell morphogenesisGO:00226041530.024
cation transmembrane transportGO:00986552380.024
regulation of cell developmentGO:00602841610.023
regulation of small gtpase mediated signal transductionGO:00510561560.023
protein localization to organelleGO:00333652800.023
positive regulation of developmental processGO:00510943140.023
generation of neuronsGO:00486991520.023
positive regulation of immune system processGO:00026842830.023
g protein coupled receptor signaling pathwayGO:00071862070.023
response to external biotic stimulusGO:00432072610.023
endomembrane system organizationGO:00102561960.023
cell growthGO:00160491600.023
positive regulation of cellular component movementGO:00512721810.023
signal transduction by phosphorylationGO:00230142970.023
response to growth factorGO:00708482050.022
single organism cell adhesionGO:00986021790.022
regulation of intracellular transportGO:00323861950.022
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.022
blood circulationGO:00080151130.022
Human
regulation of cell cycleGO:00517263930.022
positive regulation of cell deathGO:00109422630.022
establishment of protein localization to organelleGO:00725941720.022
positive regulation of cell migrationGO:00303351720.022
negative regulation of response to external stimulusGO:0032102830.022
segmentationGO:003528240.022
Mouse
epithelium migrationGO:00901321190.021
negative regulation of proteolysisGO:00458611320.021
regulation of gtp catabolic processGO:00331241800.021
positive regulation of cell motilityGO:20001471770.021
cellular response to growth factor stimulusGO:00713631970.021
divalent metal ion transportGO:00708381520.021
epithelial cell migrationGO:00106311190.021
positive regulation of gtp catabolic processGO:00331261660.021
cell morphogenesis involved in differentiationGO:00009041440.021
regulation of ras gtpase activityGO:00323181280.021
sulfur compound metabolic processGO:00067901010.020
cellular macromolecular complex assemblyGO:00346223240.020
tissue migrationGO:00901301190.020
innate immune responseGO:00450871780.020
protein oligomerizationGO:00512591730.020
negative regulation of cellular amino acid metabolic processGO:004576320.020
metencephalon developmentGO:002203720.020
positive regulation of gtpase activityGO:00435471660.020
negative regulation of cellular amine metabolic processGO:003323930.020
cellular response to cytokine stimulusGO:00713451810.020
neuron differentiationGO:00301821380.020
cellular response to dna damage stimulusGO:00069743790.020
cellular cation homeostasisGO:00300031630.020
organ morphogenesisGO:00098871470.020
monocarboxylic acid biosynthetic processGO:0072330670.020
regulation of ras protein signal transductionGO:00465781550.020
mitotic cell cycleGO:00002783260.020
cellular response to organic cyclic compoundGO:00714071270.020
regulation of body fluid levelsGO:0050878990.020
oocyte differentiationGO:000999420.020
cellular metal ion homeostasisGO:00068751460.020
regulation of cytoplasmic transportGO:19036491490.020
small molecule catabolic processGO:0044282920.020
wound healingGO:00420601150.020
hormone metabolic processGO:0042445610.020
regulation of response to woundingGO:19030341010.020
positive regulation of transferase activityGO:00513472270.020
regulation of membrane potentialGO:0042391950.020
oocyte developmentGO:004859910.020
morphogenesis of embryonic epitheliumGO:001633140.020
positive regulation of locomotionGO:00400171860.019
negative regulation of cell differentiationGO:00455961710.019
response to other organismGO:00517072610.019
regulation of growthGO:00400081650.019
regulation of cytoskeleton organizationGO:00514931770.019
sensory perception of painGO:001923340.019
cell cell signalingGO:00072671550.019
inorganic ion transmembrane transportGO:00986602310.019
regulation of cellular response to stressGO:00801352440.019
regulation of gtpase activityGO:00430871800.019
response to organonitrogen compoundGO:00102431560.019
inorganic cation transmembrane transportGO:00986621940.019
blastoderm segmentationGO:000735020.019
Mouse
positive regulation of protein kinase activityGO:00458601900.019
cell activationGO:00017752130.019
carbohydrate derivative biosynthetic processGO:19011372070.019
actin filament based movementGO:0030048170.019
response to hormoneGO:00097251750.019
protein targetingGO:00066051870.019
positive regulation of protein transportGO:00512221350.019
epithelial cell differentiationGO:00308551410.018
cellular protein catabolic processGO:00442572610.018
positive regulation of apoptotic processGO:00430652460.018
mitotic cell cycle processGO:19030472860.018
cell part morphogenesisGO:00329901370.018
cell type specific apoptotic processGO:00972851250.018
neurological system processGO:00508771630.018
response to lipidGO:00339932060.018
proteolysis involved in cellular protein catabolic processGO:00516032440.018
positive regulation of cellular component biogenesisGO:00440891580.018
neurotransmitter secretionGO:000726940.018
divalent inorganic cation transportGO:00725111580.018
negative regulation of transportGO:00510511760.018
reactive oxygen species metabolic processGO:0072593750.018
peripheral nervous system developmentGO:000742220.018
protein localization to membraneGO:00726571600.018
regulation of cell growthGO:00015581350.018
maintenance of locationGO:00512351120.018
regulation of defense responseGO:00313471540.018
divalent inorganic cation homeostasisGO:00725071360.018
taxisGO:00423301570.018
spermatid differentiationGO:004851540.018
negative regulation of intracellular signal transductionGO:19025321830.018
matingGO:000761810.018
mapk cascadeGO:00001652880.018
coagulationGO:0050817780.017
sequestering of metal ionGO:0051238240.017
negative regulation of protein modification processGO:00314002000.017
glycerolipid metabolic processGO:00464861070.017
chemotaxisGO:00069351570.017
cerebellum developmentGO:002154920.017
single organismal cell cell adhesionGO:00163371480.017
salivary gland morphogenesisGO:000743540.017
anterior posterior axis specificationGO:000994820.017
Mouse
negative regulation of cell migrationGO:00303361020.017
circulatory system processGO:00030131130.017
Human
actin mediated cell contractionGO:0070252120.017
positive regulation of cell differentiationGO:00455972110.017
actin filament organizationGO:00070151280.017
hindbrain developmentGO:003090230.017
regulation of immune responseGO:00507762010.017
muscle contractionGO:0006936730.017
wnt signaling pathwayGO:00160551560.017
positive regulation of secretionGO:00510471160.017
phospholipid metabolic processGO:0006644990.017
steroid metabolic processGO:0008202940.016
cellular response to nitrogen compoundGO:19016991440.016
regulation of vesicle mediated transportGO:00606271300.016
regulation of cell cycle processGO:00105642660.016
cell fate determinationGO:000170930.016
organic hydroxy compound biosynthetic processGO:1901617710.016
blood coagulationGO:0007596760.016
cofactor metabolic processGO:0051186870.016
endocytosisGO:00068971590.016
angiogenesisGO:00015251470.016
sequestering of calcium ionGO:0051208170.016
fatty acid metabolic processGO:00066311150.016
carboxylic acid catabolic processGO:0046395710.016
epithelial cell proliferationGO:00506731280.016
positive regulation of cytokine productionGO:00018191670.016
regulation of protein serine threonine kinase activityGO:00719001790.016
negative regulation of cell motilityGO:20001461040.016
neuron developmentGO:00486661130.016
nerve developmentGO:002167540.016
regulation of actin filament based processGO:00329701410.016
tissue regenerationGO:004224630.016
positive regulation of secretion by cellGO:19035321080.016
positive regulation of organelle organizationGO:00106381950.016
regulation of neurotransmitter secretionGO:004692830.016
reactive oxygen species biosynthetic processGO:190340940.016
posttranscriptional regulation of gene expressionGO:00106082130.016
calcium ion transportGO:00068161470.016
blood vessel developmentGO:00015681720.016
endothelial cell migrationGO:0043542860.016
purine ribonucleoside monophosphate metabolic processGO:00091671860.016
behaviorGO:00076101120.016
spermatid developmentGO:000728640.016
protein modification by small protein conjugationGO:00324463420.016
brain developmentGO:0007420970.016
cell projection assemblyGO:00300311260.016
regulation of wound healingGO:0061041560.016
negative regulation of peptidase activityGO:0010466910.016
microtubule based processGO:00070172100.016
regulation of cell projection organizationGO:00313441070.016
head developmentGO:00603221080.016
regulation of sequence specific dna binding transcription factor activityGO:00510902110.016
cellular protein complex assemblyGO:00436231880.016
negative regulation of locomotionGO:00400131180.016
mitochondrion organizationGO:00070051560.016
neuron projection developmentGO:00311751060.015
cellular divalent inorganic cation homeostasisGO:00725031280.015
limbic system developmentGO:002176130.015
symbiosis encompassing mutualism through parasitismGO:00444031560.015
Human
response to drugGO:0042493810.015
cellular modified amino acid metabolic processGO:0006575640.015
atp metabolic processGO:00460341760.015
epidermis morphogenesisGO:004873030.015
calcium ion homeostasisGO:00550741220.015
metal ion homeostasisGO:00550651690.015
organelle assemblyGO:00709251760.015
blood vessel morphogenesisGO:00485141620.015
regulation of neurogenesisGO:0050767820.015
regulation of multi organism processGO:00439001570.015
protein homooligomerizationGO:00512601000.015
protein ubiquitinationGO:00165673140.015
regulation of apoptotic signaling pathwayGO:20012331750.015
sensory perceptionGO:00076001030.015
organic acid catabolic processGO:0016054710.015
cell substrate adhesionGO:00315891320.015
negative regulation of protein phosphorylationGO:00019331400.015
inner ear morphogenesisGO:004247240.015
chromatin organizationGO:00063253510.015
establishment of protein localization to membraneGO:00901501210.015
plasma membrane organizationGO:00070091150.015
positive regulation of kinase activityGO:00336742040.015
response to metal ionGO:0010038840.015
regulation of actin cytoskeleton organizationGO:00329561160.015
negative regulation of cell adhesionGO:0007162640.015
glial cell migrationGO:000834740.015
alcohol metabolic processGO:00060661140.015
negative regulation of organelle organizationGO:00106391260.014
central nervous system developmentGO:00074171230.014
regulation of epithelial cell migrationGO:0010632930.014
gamma aminobutyric acid signaling pathwayGO:000721430.014
interspecies interaction between organismsGO:00444191560.014
Human
peptidyl tyrosine phosphorylationGO:00181081700.014
nuclear transportGO:00511691790.014
compound eye developmentGO:004874910.014
nucleocytoplasmic transportGO:00069131760.014
response to inorganic substanceGO:00100351270.014
tripartite regional subdivisionGO:000735120.014
Mouse
cellular calcium ion homeostasisGO:00068741170.014
regulation of protein complex assemblyGO:00432541470.014
negative regulation of endopeptidase activityGO:0010951840.014
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.014
cellular response to organonitrogen compoundGO:00714171240.014
rhythmic behaviorGO:000762220.014
regulation of epithelial cell proliferationGO:00506781130.014
regulation of neural precursor cell proliferationGO:200017740.014
positive regulation of proteolysisGO:00458621420.014
regulation of dna metabolic processGO:00510521530.014
anterior posterior axis specification embryoGO:000859520.014
Mouse
response to fungusGO:000962040.014
regulation of protein catabolic processGO:00421761550.014
modification dependent macromolecule catabolic processGO:00436322120.014
positive regulation of ion transportGO:0043270870.014
regulation of cysteine type endopeptidase activityGO:20001161270.014
regulation of reactive oxygen species biosynthetic processGO:190342630.014
action potentialGO:0001508340.014
multi organism cellular processGO:00447641560.014
Human
regulation of intracellular protein transportGO:00331571230.014
peptidyl tyrosine modificationGO:00182121700.014
modification dependent protein catabolic processGO:00199412090.014
proteasomal protein catabolic processGO:00104981760.014
positive regulation of mapk cascadeGO:00434101900.014
nucleoside monophosphate metabolic processGO:00091231910.014
regulation of reactive oxygen species metabolic processGO:2000377410.013
tissue morphogenesisGO:0048729960.013
glycoprotein metabolic processGO:00091001100.013
protein importGO:00170381300.013
ubiquitin dependent protein catabolic processGO:00065112060.013
regulation of endothelial cell migrationGO:0010594670.013
spinal cord developmentGO:002151040.013
purine nucleoside monophosphate metabolic processGO:00091261860.013
reactive nitrogen species metabolic processGO:200105730.013
cell projection morphogenesisGO:00488581290.013
negative regulation of phosphorylationGO:00423261740.013
vasculature developmentGO:00019441810.013
associative learningGO:000830610.013
negative regulation of transferase activityGO:00513481240.013
regulation of homeostatic processGO:00328441210.013
regulation of mapk cascadeGO:00434082620.013
negative regulation of immune system processGO:00026831360.013
regulation of coagulationGO:0050818440.013
cellular response to hormone stimulusGO:00328701250.013
ribonucleoside monophosphate metabolic processGO:00091611870.013
embryonic epithelial tube formationGO:000183840.013
carboxylic acid transportGO:0046942630.013
circadian behaviorGO:004851220.013
protein localization to nucleusGO:00345041360.013
immune system developmentGO:00025201950.013
syncytium formation by plasma membrane fusionGO:000076820.013
lipid transportGO:0006869900.013
alpha amino acid metabolic processGO:1901605720.013
negative regulation of cell cycleGO:00457861930.013
hemopoiesisGO:00300971800.013
lipid localizationGO:00108761060.013
organophosphate biosynthetic processGO:00904071630.013
organic hydroxy compound transportGO:0015850630.013
regulation of ion transportGO:00432691890.013
extrinsic apoptotic signaling pathwayGO:00971911190.013
regulation of angiogenesisGO:0045765920.013
regulation of vasculature developmentGO:1901342970.013
coenzyme metabolic processGO:0006732650.013
chromatin modificationGO:00165682980.013
regulation of metal ion transportGO:00109591200.013
i kappab kinase nf kappab signalingGO:00072491660.013
post embryonic organ developmentGO:004856910.012
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.012
ribonucleoside monophosphate catabolic processGO:00091581580.012
cellular response to lipidGO:00713961270.012
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.012
regulation of transmembrane transportGO:00347621390.012
purine ribonucleoside monophosphate catabolic processGO:00091691580.012
morphogenesis of a polarized epitheliumGO:000173830.012
inflammatory responseGO:0006954790.012
organ formationGO:004864530.012
regulation of blood coagulationGO:0030193420.012
glycerophospholipid metabolic processGO:0006650840.012
neuroblast proliferationGO:000740540.012
regulation of i kappab kinase nf kappab signalingGO:00431221620.012
regulation of wnt signaling pathwayGO:00301111230.012
positive regulation of synaptic transmissionGO:005080640.012
multicellular organismal response to stressGO:003355510.012
positive regulation of intracellular transportGO:00323881040.012
atp catabolic processGO:00062001570.012

PCSK6 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.060
inherited metabolic disorderDOID:6552420.053
central nervous system diseaseDOID:3311860.026
nervous system diseaseDOID:8634310.026
amino acid metabolic disorderDOID:9252500.023
musculoskeletal system diseaseDOID:172230.023
immune system diseaseDOID:29141550.020
disease of cellular proliferationDOID:145661740.018
cancerDOID:1621670.018
organ system cancerDOID:00506861640.018
cardiovascular system diseaseDOID:12871060.017
neurodegenerative diseaseDOID:12891020.016
sensory system diseaseDOID:00501552030.016
brain diseaseDOID:936730.015
hematopoietic system diseaseDOID:741000.014
connective tissue diseaseDOID:651090.012