Homo sapiens

0 known processes

FRAS1

Fraser syndrome 1

(Aliases: KIAA1500,FLJ22031,DKFZp686P08111,DKFZp686I05113,FLJ14927)

FRAS1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
amine metabolic processGO:0009308440.112
cell developmentGO:00484683280.092
cellular amine metabolic processGO:0044106410.085
nervous system developmentGO:00073992930.084
post embryonic developmentGO:000979120.082
regulation of cell differentiationGO:00455953930.081
regulation of cellular amino acid metabolic processGO:000652160.074
regulation of cellular amine metabolic processGO:0033238110.072
positive regulation of cellular amino acid metabolic processGO:004576430.068
cellular component morphogenesisGO:00329893140.063
locomotory behaviorGO:000762610.061
cell morphogenesisGO:00009022960.061
cellular ketone metabolic processGO:0042180800.060
rho protein signal transductionGO:0007266260.055
positive regulation of cellular amine metabolic processGO:003324070.054
small gtpase mediated signal transductionGO:0007264780.053
actin filament based processGO:00300292240.050
positive regulation of phosphorylationGO:00423273940.050
positive regulation of developmental processGO:00510943140.050
segmentationGO:003528240.049
ras protein signal transductionGO:0007265730.048
circulatory system developmentGO:00723592620.048
cellular response to endogenous stimulusGO:00714953360.047
positive regulation of cell differentiationGO:00455972110.046
cellular amino acid metabolic processGO:00065201160.045
ion transmembrane transportGO:00342203380.045
hindbrain developmentGO:003090230.045
purine nucleotide catabolic processGO:00061954050.044
epithelium developmentGO:00604292270.043
Mouse
neuron differentiationGO:00301821380.043
single organism cellular localizationGO:19025803320.042
negative regulation of catalytic activityGO:00430863350.042
neurogenesisGO:00220081690.042
negative regulation of phosphorus metabolic processGO:00105632670.041
determination of adult lifespanGO:000834020.041
regulation of cellular ketone metabolic processGO:0010565500.041
system processGO:00030083490.041
transmembrane transportGO:00550853990.041
signal transduction by phosphorylationGO:00230142970.040
organ morphogenesisGO:00098871470.040
Zebrafish Mouse
multicellular organismal agingGO:001025930.040
anatomical structure formation involved in morphogenesisGO:00486462840.039
positive regulation of hydrolase activityGO:00513453310.039
enzyme linked receptor protein signaling pathwayGO:00071673030.039
positive regulation of cellular component organizationGO:00511303760.039
membrane organizationGO:00610242920.039
negative regulation of cellular protein metabolic processGO:00322693530.039
gtp metabolic processGO:00460392390.039
cell projection organizationGO:00300302520.038
negative regulation of protein metabolic processGO:00512483910.038
nucleotide catabolic processGO:00091664080.038
ribonucleotide catabolic processGO:00092614050.038
biological adhesionGO:00226103310.038
organophosphate catabolic processGO:00464344300.037
adult locomotory behaviorGO:000834410.037
mapk cascadeGO:00001652880.037
regulation of anatomical structure morphogenesisGO:00226032860.037
negative regulation of developmental processGO:00510932470.037
positive regulation of cell proliferationGO:00082843010.037
cardiovascular system developmentGO:00723582620.036
anterior posterior axis specificationGO:000994820.036
lipid metabolic processGO:00066293810.036
purine containing compound catabolic processGO:00725234110.036
oogenesisGO:004847720.036
regulation of cell motilityGO:20001452990.036
female gamete generationGO:000729220.036
generation of neuronsGO:00486991520.036
morphogenesis of embryonic epitheliumGO:001633140.035
regulation of locomotionGO:00400123290.035
purine nucleoside catabolic processGO:00061523980.035
regulation of cellular component movementGO:00512703340.035
positive regulation of protein phosphorylationGO:00019343130.034
negative regulation of multicellular organismal processGO:00512413170.034
nucleoside catabolic processGO:00091644080.034
cell adhesionGO:00071553250.033
negative regulation of phosphate metabolic processGO:00459362670.033
nucleoside phosphate catabolic processGO:19012924120.033
response to abiotic stimulusGO:00096283360.033
nucleoside triphosphate catabolic processGO:00091433940.033
cytoplasmic transportGO:00164823790.033
single organism membrane organizationGO:00448022680.033
neuron developmentGO:00486661130.032
regulation of nucleotide metabolic processGO:00061402690.032
blood vessel morphogenesisGO:00485141620.032
ribonucleoside triphosphate catabolic processGO:00092033910.032
purine ribonucleoside metabolic processGO:00461284370.031
tube developmentGO:00352951250.031
positive regulation of catabolic processGO:00098963100.031
blastoderm segmentationGO:000735020.031
motor neuron axon guidanceGO:000804520.031
neurological system processGO:00508771630.031
purine ribonucleoside triphosphate metabolic processGO:00092054110.030
dephosphorylationGO:00163112090.030
response to oxygen containing compoundGO:19017003690.030
glycosyl compound catabolic processGO:19016584130.030
angiogenesisGO:00015251470.030
regenerationGO:003109940.029
blood vessel developmentGO:00015681720.029
organ formationGO:004864530.029
nucleoside triphosphate metabolic processGO:00091414220.029
purine ribonucleotide catabolic processGO:00091544040.029
regulation of cell migrationGO:00303342890.029
regulation of transferase activityGO:00513383550.029
intracellular protein transportGO:00068862700.029
positive regulation of mapk cascadeGO:00434101900.029
regulation of cell cycleGO:00517263930.029
ribonucleoside catabolic processGO:00424544060.029
cellular macromolecule catabolic processGO:00442653800.029
growthGO:00400072020.029
wnt signaling pathwayGO:00160551560.028
cellular response to oxygen containing compoundGO:19017012760.028
cell morphogenesis involved in differentiationGO:00009041440.028
cell projection morphogenesisGO:00488581290.028
purine nucleoside triphosphate metabolic processGO:00091444120.027
protein localization to organelleGO:00333652800.027
regulation of purine nucleotide metabolic processGO:19005422640.027
cell part morphogenesisGO:00329901370.027
inorganic ion transmembrane transportGO:00986602310.027
regulation of cell developmentGO:00602841610.027
brain developmentGO:0007420970.027
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.027
canonical wnt signaling pathwayGO:00600701160.027
neuromuscular junction developmentGO:000752830.027
tissue morphogenesisGO:0048729960.026
Mouse
endomembrane system organizationGO:00102561960.026
negative regulation of programmed cell deathGO:00430693210.026
muscle structure developmentGO:0061061980.026
negative regulation of hydrolase activityGO:00513461820.026
cell growthGO:00160491600.026
guanosine containing compound catabolic processGO:19010692390.026
cation transportGO:00068123310.026
cation transmembrane transportGO:00986552380.025
purine nucleoside triphosphate catabolic processGO:00091463920.025
regulation of protein localizationGO:00328802960.025
chemical homeostasisGO:00488783060.025
regulation of wnt signaling pathwayGO:00301111230.025
regulation of cell cycle processGO:00105642660.025
negative regulation of cell deathGO:00605483450.024
startle responseGO:000196430.024
regulation of protein kinase activityGO:00458592890.024
regulation of mapk cascadeGO:00434082620.024
guanosine containing compound metabolic processGO:19010682440.024
chromatin modificationGO:00165682980.024
mitotic cell cycleGO:00002783260.024
negative regulation of apoptotic processGO:00430663160.024
anterior posterior axis specification embryoGO:000859520.024
memoryGO:000761330.024
regulation of proteolysisGO:00301622930.024
positive regulation of nucleotide metabolic processGO:00459812300.023
epithelial cell differentiationGO:00308551410.023
central nervous system developmentGO:00074171230.023
negative regulation of cell proliferationGO:00082852280.023
protein maturationGO:00516042330.023
sensory perception of smellGO:000760820.023
positive regulation of cellular catabolic processGO:00313312840.023
mitotic cell cycle processGO:19030472860.023
neuron projection developmentGO:00311751060.023
regulation of cellular response to stressGO:00801352440.023
regulation of establishment of protein localizationGO:00702012420.023
organophosphate biosynthetic processGO:00904071630.022
oocyte developmentGO:004859910.022
positive regulation of cell deathGO:00109422630.022
negative regulation of locomotionGO:00400131180.022
purine ribonucleoside triphosphate catabolic processGO:00092073910.022
actin cytoskeleton organizationGO:00300362070.022
regulation of gtp catabolic processGO:00331241800.022
negative regulation of transportGO:00510511760.022
carbohydrate metabolic processGO:00059752070.022
somitogenesisGO:000175620.022
gtp catabolic processGO:00061842370.022
regulation of gtpase activityGO:00430871800.022
protein catabolic processGO:00301633250.022
regulation of growthGO:00400081650.021
protein targetingGO:00066051870.021
ribonucleoside triphosphate metabolic processGO:00091994120.021
tripartite regional subdivisionGO:000735120.021
regulation of cellular component biogenesisGO:00440872810.021
positive regulation of purine nucleotide metabolic processGO:19005442270.021
peripheral nervous system developmentGO:000742220.021
regulation of kinase activityGO:00435493140.021
ossificationGO:00015031210.021
oocyte differentiationGO:000999420.021
negative regulation of protein modification processGO:00314002000.021
response to organic cyclic compoundGO:00140702040.021
regulation of axon guidanceGO:190266730.021
protein processingGO:00164852260.021
ameboidal type cell migrationGO:00016671350.021
nucleocytoplasmic transportGO:00069131760.020
purine ribonucleoside catabolic processGO:00461303980.020
specification of organ identityGO:001009230.020
single organism cell adhesionGO:00986021790.020
cellular lipid metabolic processGO:00442553030.020
neurotransmitter secretionGO:000726940.020
vesicle mediated transportGO:00161923710.020
rhythmic behaviorGO:000762220.020
nuclear transportGO:00511691790.020
posttranscriptional regulation of gene expressionGO:00106082130.020
vasculature developmentGO:00019441810.020
positive regulation of nucleotide catabolic processGO:00308131850.020
positive regulation of apoptotic processGO:00430652460.020
organonitrogen compound biosynthetic processGO:19015662000.020
taxisGO:00423301570.020
regulation of protein transportGO:00512232130.020
regulation of cell growthGO:00015581350.020
covalent chromatin modificationGO:00165692540.020
regulation of ras gtpase activityGO:00323181280.020
photoreceptor cell differentiationGO:004653020.019
cellular response to dna damage stimulusGO:00069743790.019
positive regulation of transportGO:00510503360.019
histone modificationGO:00165702510.019
regulation of ras protein signal transductionGO:00465781550.019
head developmentGO:00603221080.019
regulation of nucleotide catabolic processGO:00308112050.019
positive regulation of nucleoside metabolic processGO:00459791860.019
secretion by cellGO:00329402260.019
chromatin organizationGO:00063253510.019
g protein coupled receptor signaling pathwayGO:00071862070.019
salivary gland morphogenesisGO:000743540.019
regulation of endopeptidase activityGO:00525481700.019
immune responseGO:00069553070.019
negative regulation of cellular component organizationGO:00511292350.019
embryonic epithelial tube formationGO:000183840.019
negative regulation of cell differentiationGO:00455961710.019
positive regulation of programmed cell deathGO:00430682490.019
negative regulation of phosphorylationGO:00423261740.019
embryonic morphogenesisGO:0048598850.019
Zebrafish Mouse
metal ion transportGO:00300012720.019
negative regulation of cell cycleGO:00457861930.019
ion homeostasisGO:00508012300.019
behaviorGO:00076101120.019
cellular homeostasisGO:00197251960.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
regulation of cytoskeleton organizationGO:00514931770.018
sensory perceptionGO:00076001030.018
cardiac muscle cell contractionGO:008600340.018
protein localization to nucleusGO:00345041360.018
negative regulation of cellular amine metabolic processGO:003323930.018
regulation of transmembrane transportGO:00347621390.018
response to nitrogen compoundGO:19016981840.018
regulation of multi organism processGO:00439001570.018
regulation of actin filament based processGO:00329701410.018
cellular macromolecular complex assemblyGO:00346223240.018
nitrogen compound transportGO:00717051910.018
positive regulation of locomotionGO:00400171860.018
alcohol metabolic processGO:00060661140.018
regulation of nervous system developmentGO:0051960880.018
regulation of purine nucleotide catabolic processGO:00331212050.018
cellular protein catabolic processGO:00442572610.018
negative regulation of cell migrationGO:00303361020.018
protein ubiquitinationGO:00165673140.018
regulation of small gtpase mediated signal transductionGO:00510561560.018
positive regulation of ras gtpase activityGO:00323201170.018
regulation of nucleoside metabolic processGO:00091182090.018
regulation of intracellular transportGO:00323861950.018
protein modification by small protein conjugationGO:00324463420.018
nerve developmentGO:002167540.018
morphogenesis of a polarized epitheliumGO:000173830.017
microtubule based processGO:00070172100.017
regulation of response to external stimulusGO:00321012220.017
protein importGO:00170381300.017
anion transportGO:00068201610.017
negative regulation of intracellular signal transductionGO:19025321830.017
plasma membrane organizationGO:00070091150.017
cellular response to growth factor stimulusGO:00713631970.017
carbohydrate derivative biosynthetic processGO:19011372070.017
response to growth factorGO:00708482050.017
chemotaxisGO:00069351570.017
tissue migrationGO:00901301190.017
modification dependent macromolecule catabolic processGO:00436322120.017
regulation of cytoplasmic transportGO:19036491490.017
proteolysis involved in cellular protein catabolic processGO:00516032440.017
regulation of peptidase activityGO:00525471800.017
positive regulation of cell migrationGO:00303351720.017
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.017
matingGO:000761810.017
actin mediated cell contractionGO:0070252120.017
regulation of intracellular protein transportGO:00331571230.017
negative regulation of transferase activityGO:00513481240.017
spermatid differentiationGO:004851540.016
establishment of protein localization to organelleGO:00725941720.016
positive regulation of cell developmentGO:0010720920.016
positive regulation of cell motilityGO:20001471770.016
single organism carbohydrate metabolic processGO:00447231930.016
lipid biosynthetic processGO:00086101770.016
regulation of axon extension involved in axon guidanceGO:004884120.016
response to lipidGO:00339932060.016
proteasomal protein catabolic processGO:00104981760.016
apoptotic signaling pathwayGO:00971902680.016
positive regulation of steroid hormone biosynthetic processGO:009003120.016
positive regulation of synaptic transmissionGO:005080640.016
regulation of cell adhesionGO:00301551660.016
organelle assemblyGO:00709251760.016
regulation of feeding behaviorGO:006025930.016
regulation of synaptic plasticityGO:004816730.016
regulation of cell projection organizationGO:00313441070.016
reactive oxygen species metabolic processGO:0072593750.016
metencephalon developmentGO:002203720.016
regulation of cell morphogenesisGO:00226041530.016
regulation of canonical wnt signaling pathwayGO:0060828880.016
cell divisionGO:00513011680.016
regulation of protein maturationGO:19033171500.016
epithelial cell proliferationGO:00506731280.016
modification dependent protein catabolic processGO:00199412090.016
organic hydroxy compound metabolic processGO:19016151470.016
regulation of neurogenesisGO:0050767820.016
regulation of mitotic cell cycleGO:00073461890.016
nuclear importGO:00511701060.016
positive regulation of gtp catabolic processGO:00331261660.016
compound eye developmentGO:004874910.016
regulation of cell morphogenesis involved in differentiationGO:0010769830.016
positive regulation of immune system processGO:00026842830.016
lung alveolus developmentGO:004828640.015
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.015
response to organonitrogen compoundGO:00102431560.015
ubiquitin dependent protein catabolic processGO:00065112060.015
patterning of blood vesselsGO:000156920.015
tissue regenerationGO:004224630.015
regulation of cytokine productionGO:00018172320.015
positive regulation of gtpase activityGO:00435471660.015
stem cell divisionGO:001714520.015
regulation of protein serine threonine kinase activityGO:00719001790.015
epithelium migrationGO:00901321190.015
osteoblast differentiationGO:0001649920.015
cardiac muscle contractionGO:0060048340.015
regulation of dna metabolic processGO:00510521530.015
regulation of epithelial cell proliferationGO:00506781130.015
limbic system developmentGO:002176130.015
circadian behaviorGO:004851220.015
response to axon injuryGO:004867810.015
cellular chemical homeostasisGO:00550821800.015
actin filament based movementGO:0030048170.015
cytokine productionGO:00018162470.015
regulation of membrane potentialGO:0042391950.015
associative learningGO:000830610.015
positive regulation of hormone biosynthetic processGO:004688640.014
inner ear morphogenesisGO:004247240.014
protein localization to membraneGO:00726571600.014
response to radiationGO:00093141510.014
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.014
innate immune responseGO:00450871780.014
regulation of dephosphorylationGO:0035303960.014
establishment of protein localization to membraneGO:00901501210.014
protein localization to plasma membraneGO:0072659930.014
cranial nerve developmentGO:002154540.014
microtubule cytoskeleton organizationGO:00002261760.014
positive regulation of protein kinase activityGO:00458601900.014
skeletal system developmentGO:0001501790.014
Zebrafish
cell substrate adhesionGO:00315891320.014
striated muscle contractionGO:0006941520.014
glycoprotein metabolic processGO:00091001100.014
morphogenesis of an epitheliumGO:0002009600.014
Mouse
regulation of protein catabolic processGO:00421761550.014
regulation of peptidyl tyrosine phosphorylationGO:00507301080.014
regulation of protein targetingGO:1903533910.014
regulation of cysteine type endopeptidase activityGO:20001161270.014
dna repairGO:00062811980.014
protein import into nucleusGO:00066061040.014
epithelial tube branching involved in lung morphogenesisGO:006044140.014
primary neural tube formationGO:001402030.014
post embryonic organ developmentGO:004856910.014
regulation of sequence specific dna binding transcription factor activityGO:00510902110.014
endodermal cell fate commitmentGO:000171140.014
cellular protein complex assemblyGO:00436231880.014
axis elongationGO:000340140.014
mesenchymal cell developmentGO:0014031500.014
spermatid developmentGO:000728640.014
protein targeting to nucleusGO:00447441040.014
cellular response to organic cyclic compoundGO:00714071270.014
neuroblast proliferationGO:000740540.014
immune system developmentGO:00025201950.014
defense responseGO:00069523150.014
single organismal cell cell adhesionGO:00163371480.014
negative regulation of cell motilityGO:20001461040.013
peptidyl tyrosine phosphorylationGO:00181081700.013
neural crest cell developmentGO:001403230.013
regulation of neurotransmitter secretionGO:004692830.013
positive regulation of proteolysisGO:00458621420.013
reproductive processGO:00224141060.013
positive regulation of transferase activityGO:00513472270.013
regulation of secretion by cellGO:19035301770.013
regulation of cell divisionGO:00513021160.013
neural tube formationGO:000184130.013
cerebellum developmentGO:002154920.013
formation of primary germ layerGO:0001704420.013
muscle system processGO:0003012810.013
endodermal cell fate specificationGO:000171440.013
single organism nuclear importGO:19025931040.013
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.013
somatic stem cell maintenanceGO:003501940.013
positive regulation of kinase activityGO:00336742040.013
stem cell developmentGO:0048864690.013
cellular response to organonitrogen compoundGO:00714171240.013
tube morphogenesisGO:0035239950.013
muscle contractionGO:0006936730.013
reactive oxygen species biosynthetic processGO:190340940.013
negative regulation of catabolic processGO:00098951040.013
endocytosisGO:00068971590.013
regulation of nucleocytoplasmic transportGO:0046822980.013
cell fate determinationGO:000170930.013
positive regulation of organelle organizationGO:00106381950.013
embryonic eye morphogenesisGO:004804820.013
negative regulation of protein maturationGO:19033181420.013
negative regulation of protein processingGO:00109551420.013
positive regulation of purine nucleotide catabolic processGO:00331231850.013
epithelial cell migrationGO:00106311190.013
positive regulation of cellular component movementGO:00512721810.013
secretionGO:00469032540.013
negative regulation of protein phosphorylationGO:00019331400.013
oxidation reduction processGO:00551143960.013
negative regulation of cellular component movementGO:00512711060.013
endoderm developmentGO:0007492330.013
Zebrafish
regulation of actin cytoskeleton organizationGO:00329561160.013
visual behaviorGO:000763220.012
regulation of neuron differentiationGO:0045664700.012
regulation of secretionGO:00510461940.012
negative regulation of organelle organizationGO:00106391260.012
protein oligomerizationGO:00512591730.012
response to hormoneGO:00097251750.012
stem cell differentiationGO:0048863930.012
peptidyl tyrosine modificationGO:00182121700.012
regulation of phosphatase activityGO:0010921810.012
positive regulation of aldosterone biosynthetic processGO:003234920.012
ectoderm developmentGO:000739830.012
digestive tract morphogenesisGO:0048546560.012
positive regulation of nervous system developmentGO:0051962540.012
negative regulation of multi organism processGO:0043901920.012
hematopoietic or lymphoid organ developmentGO:00485341860.012
cell projection assemblyGO:00300311260.012
cell cycle phase transitionGO:00447701730.012
regulation of rho protein signal transductionGO:0035023790.012
digestive tract developmentGO:0048565750.012
neuron projection regenerationGO:003110210.012
cellular metal ion homeostasisGO:00068751460.012
prostate gland developmentGO:003085030.012
positive regulation of cellular component biogenesisGO:00440891580.012
positive regulation of dna metabolic processGO:0051054730.012
receptor metabolic processGO:0043112810.012
interspecies interaction between organismsGO:00444191560.012
gland developmentGO:0048732480.012
negative regulation of kinase activityGO:00336731060.012
cellular response to nitrogen compoundGO:19016991440.012
divalent inorganic cation transportGO:00725111580.012
positive regulation of protein transportGO:00512221350.012
regulation of behaviorGO:0050795820.012
regulation of neuron projection developmentGO:0010975570.012
regulation of protein import into nucleusGO:0042306780.012
regulation of reactive oxygen species metabolic processGO:2000377410.012
neural tube closureGO:000184330.012
cdc42 protein signal transductionGO:003248840.012
multi organism cellular processGO:00447641560.012
glycerophospholipid metabolic processGO:0006650840.012
glycerolipid metabolic processGO:00464861070.012
negative regulation of canonical wnt signaling pathwayGO:0090090550.012
embryo developmentGO:00097901230.012
Zebrafish Mouse
retinal ganglion cell axon guidanceGO:003129020.012
negative regulation of cell growthGO:0030308830.012
nucleotide biosynthetic processGO:00091651090.012
dna replicationGO:00062601160.011
regulation of ion transportGO:00432691890.011
positive regulation of intracellular transportGO:00323881040.011
rna processingGO:00063962550.011
multicellular organismal homeostasisGO:0048871670.011
melanin metabolic processGO:000658210.011
cellular component assembly involved in morphogenesisGO:0010927730.011
pattern specification processGO:0007389430.011
somatic stem cell divisionGO:004810310.011
sensory perception of painGO:001923340.011
collateral sproutingGO:004866820.011
inorganic cation transmembrane transportGO:00986621940.011
intracellular receptor signaling pathwayGO:00305221040.011
regulation of vesicle mediated transportGO:00606271300.011
cell migration involved in gastrulationGO:004207410.011
negative regulation of cellular catabolic processGO:0031330830.011
muscle cell differentiationGO:0042692630.011
embryonic camera type eye morphogenesisGO:004859620.011
endothelial cell migrationGO:0043542860.011
establishment or maintenance of apical basal cell polarityGO:003508820.011
regulation of reactive oxygen species biosynthetic processGO:190342630.011
negative regulation of wnt signaling pathwayGO:0030178690.011

FRAS1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
sensory system diseaseDOID:00501552030.024
nervous system diseaseDOID:8634310.024
disease of metabolismDOID:00146672950.024
central nervous system diseaseDOID:3311860.022
eye and adnexa diseaseDOID:14921500.021
eye diseaseDOID:56141490.021
musculoskeletal system diseaseDOID:172230.020
inherited metabolic disorderDOID:6552420.018
disease of cellular proliferationDOID:145661740.018
cancerDOID:1621670.018
organ system cancerDOID:00506861640.018
retinal diseaseDOID:56791180.013
connective tissue diseaseDOID:651090.012
bone diseaseDOID:0080001880.012