Homo sapiens

97 known processes

CAMK4

calcium/calmodulin-dependent protein kinase IV

(Aliases: caMK,CaMK-GR,MGC36771,CaMK IV,IV)

CAMK4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of cellular amine metabolic processGO:0033238110.112
cellular ketone metabolic processGO:0042180800.111
cellular amine metabolic processGO:0044106410.107
regulation of cellular ketone metabolic processGO:0010565500.105
amine metabolic processGO:0009308440.101
cellular amino acid metabolic processGO:00065201160.101
regulation of cellular amino acid metabolic processGO:000652160.095
positive regulation of cellular amino acid metabolic processGO:004576430.081
positive regulation of cellular amine metabolic processGO:003324070.079
positive regulation of phosphorylationGO:00423273940.071
cytokine productionGO:00018162470.071
transmembrane transportGO:00550853990.070
post embryonic developmentGO:000979120.068
locomotory behaviorGO:000762610.064
positive regulation of immune system processGO:00026842830.061
secretionGO:00469032540.058
positive regulation of cellular component organizationGO:00511303760.057
cation transportGO:00068123310.057
positive regulation of transportGO:00510503360.056
Mouse
metal ion transportGO:00300012720.056
ion transmembrane transportGO:00342203380.055
secretion by cellGO:00329402260.055
regulation of secretion by cellGO:19035301770.054
lipid metabolic processGO:00066293810.054
cytoplasmic transportGO:00164823790.053
Mouse
regulation of secretionGO:00510461940.051
defense responseGO:00069523150.051
ribonucleotide catabolic processGO:00092614050.051
nucleoside triphosphate metabolic processGO:00091414220.049
response to abiotic stimulusGO:00096283360.049
immune responseGO:00069553070.048
purine ribonucleotide catabolic processGO:00091544040.048
inorganic ion transmembrane transportGO:00986602310.047
nucleotide catabolic processGO:00091664080.047
small gtpase mediated signal transductionGO:0007264780.046
purine ribonucleoside metabolic processGO:00461284370.046
positive regulation of hydrolase activityGO:00513453310.046
negative regulation of catalytic activityGO:00430863350.045
glycosyl compound catabolic processGO:19016584130.045
purine nucleoside triphosphate metabolic processGO:00091444120.045
purine containing compound catabolic processGO:00725234110.045
ras protein signal transductionGO:0007265730.045
nucleoside catabolic processGO:00091644080.045
organophosphate catabolic processGO:00464344300.045
nucleoside phosphate catabolic processGO:19012924120.044
purine ribonucleoside triphosphate metabolic processGO:00092054110.044
ribonucleoside catabolic processGO:00424544060.044
cation transmembrane transportGO:00986552380.044
regulation of nucleotide metabolic processGO:00061402690.044
female gamete generationGO:000729220.043
nervous system developmentGO:00073992930.043
negative regulation of protein metabolic processGO:00512483910.043
memoryGO:000761330.043
cellular response to endogenous stimulusGO:00714953360.043
purine nucleoside triphosphate catabolic processGO:00091463920.042
purine nucleotide catabolic processGO:00061954050.042
regulation of protein kinase activityGO:00458592890.041
multicellular organismal agingGO:001025930.041
nucleoside triphosphate catabolic processGO:00091433940.041
system processGO:00030083490.040
regulation of mapk cascadeGO:00434082620.040
purine ribonucleoside catabolic processGO:00461303980.040
chemical homeostasisGO:00488783060.040
ribonucleoside triphosphate catabolic processGO:00092033910.040
positive regulation of protein phosphorylationGO:00019343130.040
ribonucleoside triphosphate metabolic processGO:00091994120.039
regulation of kinase activityGO:00435493140.039
regulation of cell cycleGO:00517263930.039
response to oxygen containing compoundGO:19017003690.039
vesicle mediated transportGO:00161923710.039
positive regulation of developmental processGO:00510943140.038
cell projection organizationGO:00300302520.038
determination of adult lifespanGO:000834020.038
regulation of locomotionGO:00400123290.038
regulation of cell differentiationGO:00455953930.038
inorganic cation transmembrane transportGO:00986621940.038
regulation of cellular component biogenesisGO:00440872810.037
regulation of purine nucleotide metabolic processGO:19005422640.037
leukocyte activationGO:00453211640.037
single organism cellular localizationGO:19025803320.037
cellular response to oxygen containing compoundGO:19017012760.037
guanosine containing compound metabolic processGO:19010682440.037
positive regulation of catabolic processGO:00098963100.037
regulation of transferase activityGO:00513383550.037
intracellular protein transportGO:00068862700.037
Mouse
negative regulation of cellular protein metabolic processGO:00322693530.037
purine nucleoside catabolic processGO:00061523980.036
cellular metal ion homeostasisGO:00068751460.036
ion homeostasisGO:00508012300.036
negative regulation of multicellular organismal processGO:00512413170.036
regulation of intracellular transportGO:00323861950.036
Mouse
cellular lipid metabolic processGO:00442553030.035
purine ribonucleoside triphosphate catabolic processGO:00092073910.035
regulation of cytokine productionGO:00018172320.035
oogenesisGO:004847720.035
regulation of ion transportGO:00432691890.035
positive regulation of cell differentiationGO:00455972110.035
neuromuscular junction developmentGO:000752830.035
cellular homeostasisGO:00197251960.035
cell adhesionGO:00071553250.034
immune system developmentGO:00025201950.034
cellular ion homeostasisGO:00068731680.034
single organism membrane organizationGO:00448022680.034
regulation of protein transportGO:00512232130.034
Mouse
cell developmentGO:00484683280.034
response to cytokineGO:00340972320.034
cellular cation homeostasisGO:00300031630.033
mapk cascadeGO:00001652880.033
positive regulation of programmed cell deathGO:00430682490.033
segmentationGO:003528240.033
g protein coupled receptor signaling pathwayGO:00071862070.033
biological adhesionGO:00226103310.033
negative regulation of cell deathGO:00605483450.032
signal transduction by phosphorylationGO:00230142970.032
regulation of cellular component movementGO:00512703340.032
protein catabolic processGO:00301633250.032
positive regulation of cellular catabolic processGO:00313312840.032
divalent inorganic cation transportGO:00725111580.032
regulation of anatomical structure morphogenesisGO:00226032860.032
cellular chemical homeostasisGO:00550821800.032
cellular component morphogenesisGO:00329893140.031
cell cell signalingGO:00072671550.031
Mouse
cation homeostasisGO:00550801890.031
gtp catabolic processGO:00061842370.031
positive regulation of apoptotic processGO:00430652460.031
positive regulation of nucleotide metabolic processGO:00459812300.031
adult locomotory behaviorGO:000834410.031
cellular response to dna damage stimulusGO:00069743790.031
membrane organizationGO:00610242920.030
cellular macromolecular complex assemblyGO:00346223240.030
protein maturationGO:00516042330.030
actin filament based processGO:00300292240.030
cellular macromolecule catabolic processGO:00442653800.030
negative regulation of developmental processGO:00510932470.030
apoptotic signaling pathwayGO:00971902680.030
regenerationGO:003109940.030
peptidyl tyrosine modificationGO:00182121700.029
positive regulation of cell deathGO:00109422630.029
regulation of proteolysisGO:00301622930.029
cell morphogenesisGO:00009022960.029
regulation of protein localizationGO:00328802960.028
Mouse
calcium ion transportGO:00068161470.028
positive regulation of mapk cascadeGO:00434101900.028
positive regulation of secretion by cellGO:19035321080.028
enzyme linked receptor protein signaling pathwayGO:00071673030.028
mitotic cell cycleGO:00002783260.028
carbohydrate derivative biosynthetic processGO:19011372070.028
protein localization to organelleGO:00333652800.028
regulation of cell motilityGO:20001452990.028
response to other organismGO:00517072610.027
gtp metabolic processGO:00460392390.027
metal ion homeostasisGO:00550651690.027
associative learningGO:000830610.027
negative regulation of phosphate metabolic processGO:00459362670.027
positive regulation of cell proliferationGO:00082843010.027
establishment of protein localization to organelleGO:00725941720.027
positive regulation of purine nucleotide metabolic processGO:19005442270.027
regulation of establishment of protein localizationGO:00702012420.026
Mouse
organonitrogen compound biosynthetic processGO:19015662000.026
negative regulation of cell proliferationGO:00082852280.026
hindbrain developmentGO:003090230.026
regulation of cellular response to stressGO:00801352440.026
hematopoietic or lymphoid organ developmentGO:00485341860.026
positive regulation of synaptic transmissionGO:005080640.026
negative regulation of programmed cell deathGO:00430693210.025
regulation of membrane potentialGO:0042391950.025
guanosine containing compound catabolic processGO:19010692390.025
cell activationGO:00017752130.025
regulation of cell cycle processGO:00105642660.025
response to biotic stimulusGO:00096072760.025
regulation of response to external stimulusGO:00321012220.025
calcium ion homeostasisGO:00550741220.025
innate immune responseGO:00450871780.025
response to external biotic stimulusGO:00432072610.025
regulation of cell developmentGO:00602841610.025
lipid biosynthetic processGO:00086101770.025
blastoderm segmentationGO:000735020.025
regulation of leukocyte activationGO:00026941150.025
neurogenesisGO:00220081690.025
negative regulation of phosphorus metabolic processGO:00105632670.025
mitotic cell cycle processGO:19030472860.024
negative regulation of cellular amino acid metabolic processGO:004576320.024
cellular response to cytokine stimulusGO:00713451810.024
negative regulation of apoptotic processGO:00430663160.024
positive regulation of secretionGO:00510471160.024
divalent inorganic cation homeostasisGO:00725071360.024
negative regulation of transportGO:00510511760.024
regulation of cell migrationGO:00303342890.024
regulation of nucleoside metabolic processGO:00091182090.024
divalent metal ion transportGO:00708381520.024
neurotransmitter secretionGO:000726940.023
negative regulation of cellular component organizationGO:00511292350.023
regulation of sequence specific dna binding transcription factor activityGO:00510902110.023
reactive nitrogen species metabolic processGO:200105730.023
response to lipidGO:00339932060.023
peptidyl tyrosine phosphorylationGO:00181081700.023
positive regulation of cell motilityGO:20001471770.023
positive regulation of protein kinase activityGO:00458601900.023
chromatin organizationGO:00063253510.023
negative regulation of cellular amine metabolic processGO:003323930.023
positive regulation of transferase activityGO:00513472270.023
neuroblast proliferationGO:000740540.023
generation of neuronsGO:00486991520.023
positive regulation of locomotionGO:00400171860.023
rho protein signal transductionGO:0007266260.023
protein targetingGO:00066051870.023
matingGO:000761810.023
regulation of peptidase activityGO:00525471800.023
growthGO:00400072020.022
hemopoiesisGO:00300971800.022
positive regulation of nucleoside metabolic processGO:00459791860.022
regulation of nucleotide catabolic processGO:00308112050.022
response to organic cyclic compoundGO:00140702040.022
glycoprotein metabolic processGO:00091001100.022
cell growthGO:00160491600.022
regulation of gtp catabolic processGO:00331241800.022
regulation of metal ion transportGO:00109591200.022
positive regulation of gtp catabolic processGO:00331261660.022
neurological system processGO:00508771630.022
nuclear transportGO:00511691790.022
Mouse
negative regulation of protein modification processGO:00314002000.022
regulation of hormone levelsGO:00108171250.022
cellular divalent inorganic cation homeostasisGO:00725031280.022
lymphocyte activationGO:00466491330.022
endomembrane system organizationGO:00102561960.022
protein processingGO:00164852260.022
regulation of cell adhesionGO:00301551660.022
histone modificationGO:00165702510.022
positive regulation of cytosolic calcium ion concentrationGO:0007204820.022
positive regulation of immune responseGO:00507781590.022
regulation of cytoplasmic transportGO:19036491490.022
Mouse
negative regulation of hydrolase activityGO:00513461820.022
motor neuron axon guidanceGO:000804520.021
muscle contractionGO:0006936730.021
actin cytoskeleton organizationGO:00300362070.021
regulation of purine nucleotide catabolic processGO:00331212050.021
regulation of transmembrane transportGO:00347621390.021
reactive oxygen species biosynthetic processGO:190340940.021
positive regulation of cellular component movementGO:00512721810.021
negative regulation of intracellular signal transductionGO:19025321830.021
nitrogen compound transportGO:00717051910.021
camp metabolic processGO:0046058610.021
regulation of synaptic plasticityGO:004816730.021
monovalent inorganic cation transportGO:00156721280.021
immune response activating signal transductionGO:0002757900.021
neuron developmentGO:00486661130.020
maintenance of locationGO:00512351120.020
proteolysis involved in cellular protein catabolic processGO:00516032440.020
nerve developmentGO:002167540.020
cellular protein catabolic processGO:00442572610.020
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.020
anatomical structure formation involved in morphogenesisGO:00486462840.020
regulation of small gtpase mediated signal transductionGO:00510561560.020
spermatid differentiationGO:004851540.020
sex determinationGO:000753030.020
regulation of reactive oxygen species biosynthetic processGO:190342630.020
protein autophosphorylationGO:00467771230.020
oocyte differentiationGO:000999420.020
rhythmic behaviorGO:000762220.020
neuron projection developmentGO:00311751060.020
positive regulation of organelle organizationGO:00106381950.020
muscle system processGO:0003012810.020
positive regulation of nucleotide catabolic processGO:00308131850.020
oocyte developmentGO:004859910.020
anterior posterior axis specificationGO:000994820.020
negative regulation of cell cycleGO:00457861930.020
chromatin modificationGO:00165682980.020
response to nitrogen compoundGO:19016981840.020
immune effector processGO:00022521590.020
cellular calcium ion homeostasisGO:00068741170.020
regulation of ras protein signal transductionGO:00465781550.020
regulation of immune responseGO:00507762010.020
blood vessel developmentGO:00015681720.020
peripheral nervous system developmentGO:000742220.020
positive regulation of ion transportGO:0043270870.020
regulation of cell projection organizationGO:00313441070.020
regulation of protein serine threonine kinase activityGO:00719001790.020
microtubule based processGO:00070172100.019
covalent chromatin modificationGO:00165692540.019
immune response regulating signaling pathwayGO:0002764970.019
cell fate determinationGO:000170930.019
spinal cord developmentGO:002151040.019
response to radiationGO:00093141510.019
myeloid cell differentiationGO:00300991170.019
cerebellum developmentGO:002154920.019
regulation of vesicle mediated transportGO:00606271300.019
anterior posterior axis specification embryoGO:000859520.019
organophosphate biosynthetic processGO:00904071630.019
carbohydrate metabolic processGO:00059752070.019
regulation of cytoskeleton organizationGO:00514931770.019
chemotaxisGO:00069351570.019
regulation of neurotransmitter secretionGO:004692830.019
small molecule biosynthetic processGO:00442831570.019
regulation of protein maturationGO:19033171500.019
sequestering of calcium ionGO:0051208170.019
nucleocytoplasmic transportGO:00069131760.019
Mouse
cell morphogenesis involved in differentiationGO:00009041440.019
regulation of ion transmembrane transportGO:00347651320.019
activation of immune responseGO:00022531140.019
gamma aminobutyric acid signaling pathwayGO:000721430.019
positive regulation of cell migrationGO:00303351720.019
regulation of cell morphogenesisGO:00226041530.019
protein ubiquitinationGO:00165673140.019
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.018
forebrain generation of neuronsGO:002187230.018
compound eye developmentGO:004874910.018
regulation of gtpase activityGO:00430871800.018
metencephalon developmentGO:002203720.018
dephosphorylationGO:00163112090.018
multi organism cellular processGO:00447641560.018
cellular response to lipidGO:00713961270.018
positive regulation of acrosome reactionGO:200034440.018
positive regulation of purine nucleotide catabolic processGO:00331231850.018
positive regulation of reactive oxygen species biosynthetic processGO:190342820.018
cardiac muscle cell contractionGO:008600340.018
regulation of endopeptidase activityGO:00525481700.018
positive regulation of gtpase activityGO:00435471660.018
regulation of homeostatic processGO:00328441210.018
positive regulation of cell developmentGO:0010720920.018
spermatid developmentGO:000728640.018
response to organonitrogen compoundGO:00102431560.018
morphogenesis of embryonic epitheliumGO:001633140.018
exocytosisGO:0006887710.018
cell part morphogenesisGO:00329901370.018
cell projection morphogenesisGO:00488581290.018
neuron differentiationGO:00301821380.018
cellular protein complex assemblyGO:00436231880.018
sequestering of metal ionGO:0051238240.018
posttranscriptional regulation of gene expressionGO:00106082130.018
long term memoryGO:000761620.018
cell divisionGO:00513011680.018
response to axon injuryGO:004867810.018
negative regulation of protein maturationGO:19033181420.018
peptidyl serine modificationGO:00182091060.017
protein modification by small protein conjugationGO:00324463420.017
multicellular organismal signalingGO:0035637340.017
monocarboxylic acid metabolic processGO:00327871850.017
positive regulation of protein transportGO:00512221350.017
Mouse
microtubule cytoskeleton organizationGO:00002261760.017
regulation of cell growthGO:00015581350.017
positive regulation of cytokine productionGO:00018191670.017
tripartite regional subdivisionGO:000735120.017
regulation of actin filament based processGO:00329701410.017
regulation of neuron differentiationGO:0045664700.017
regulation of defense responseGO:00313471540.017
protein acylationGO:00435431380.017
negative regulation of phosphorylationGO:00423261740.017
regulation of cell activationGO:00508651250.017
circadian behaviorGO:004851220.017
angiogenesisGO:00015251470.017
regulation of acrosome reactionGO:006004640.017
regulation of transmission of nerve impulseGO:005196920.017
nucleoside phosphate biosynthetic processGO:19012931090.017
circulatory system developmentGO:00723592620.017
regulation of growthGO:00400081650.017
salivary gland morphogenesisGO:000743540.017
regulation of protein catabolic processGO:00421761550.017
limbic system developmentGO:002176130.017
regulation of neural precursor cell proliferationGO:200017740.016
single organism carbohydrate metabolic processGO:00447231930.016
photoreceptor cell differentiationGO:004653020.016
positive regulation of reactive oxygen species metabolic processGO:2000379240.016
regulation of mitotic cell cycleGO:00073461890.016
positive regulation of cellular component biogenesisGO:00440891580.016
visual behaviorGO:000763220.016
regulation of i kappab kinase nf kappab signalingGO:00431221620.016
single organism cell adhesionGO:00986021790.016
phagocytosis recognitionGO:000691030.016
interspecies interaction between organismsGO:00444191560.016
cloacal septationGO:006019710.016
negative regulation of protein processingGO:00109551420.016
calcium ion transmembrane transportGO:0070588760.016
t cell differentiation in thymusGO:003307740.016
response to woundingGO:00096111680.016
oxidation reduction processGO:00551143960.016
peptidyl serine phosphorylationGO:00181051010.016
positive regulation of kinase activityGO:00336742040.016
cytokine mediated signaling pathwayGO:00192211090.016
cell cycle phase transitionGO:00447701730.016
regulation of neurogenesisGO:0050767820.016
potassium ion transmembrane transportGO:0071805600.016
thymus developmentGO:004853830.016
negative regulation of protein phosphorylationGO:00019331400.016
protein oligomerizationGO:00512591730.016
negative regulation of cell differentiationGO:00455961710.016
regulation of protein processingGO:00706131500.016
epithelial cell differentiationGO:00308551410.016
regulation of meiotic cell cycleGO:005144540.015
positive regulation of proteolysisGO:00458621420.015
blood vessel morphogenesisGO:00485141620.015
ameboidal type cell migrationGO:00016671350.015
nucleotide biosynthetic processGO:00091651090.015
organelle assemblyGO:00709251760.015
organ formationGO:004864530.015
viral processGO:00160321460.015
negative regulation of proteolysisGO:00458611320.015
regulation of apoptotic signaling pathwayGO:20012331750.015
regulation of vasculature developmentGO:1901342970.015
cellular response to nitrogen compoundGO:19016991440.015
potassium ion transportGO:0006813620.015
cyclic nucleotide metabolic processGO:0009187820.015
symbiosis encompassing mutualism through parasitismGO:00444031560.015
regulation of camp metabolic processGO:0030814520.015
response to growth factorGO:00708482050.015
cellular response to growth factor stimulusGO:00713631970.015
protein secretionGO:0009306980.015
syncytium formation by plasma membrane fusionGO:000076820.015
cytosolic calcium ion homeostasisGO:0051480890.015
second messenger mediated signalingGO:0019932780.015
mitotic cell cycle phase transitionGO:00447721620.015
regulation of calcium ion transportGO:0051924790.015
ribose phosphate biosynthetic processGO:0046390820.015
cgmp catabolic processGO:004606930.015
organic hydroxy compound metabolic processGO:19016151470.015
release of cytoplasmic sequestered nf kappabGO:000858840.015
cardiovascular system developmentGO:00723582620.015
visual learningGO:000854210.015
epithelium developmentGO:00604292270.015
negative regulation of synaptic transmissionGO:005080520.015
actin mediated cell contractionGO:0070252120.015
regulation of peptidyl tyrosine phosphorylationGO:00507301080.015
cellular response to organic cyclic compoundGO:00714071270.015
i kappab kinase nf kappab signalingGO:00072491660.015
positive regulation of protein serine threonine kinase activityGO:00719021190.015
regulation of ras gtpase activityGO:00323181280.015
neural crest cell developmentGO:001403230.015
hindlimb morphogenesisGO:003513720.015
protein localization to nucleusGO:00345041360.015
startle responseGO:000196430.014
reactive oxygen species metabolic processGO:0072593750.014
vasculature developmentGO:00019441810.014
protein localization to membraneGO:00726571600.014
inner ear morphogenesisGO:004247240.014
sensory perception of painGO:001923340.014
endocytosisGO:00068971590.014
cardiac muscle contractionGO:0060048340.014
protein importGO:00170381300.014
stem cell divisionGO:001714520.014
regulation of dna metabolic processGO:00510521530.014
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.014
regulation of multi organism processGO:00439001570.014
positive regulation of ras gtpase activityGO:00323201170.014
membrane hyperpolarizationGO:006008110.014
positive regulation of defense responseGO:0031349870.014
head developmentGO:00603221080.014
positive regulation of intracellular transportGO:00323881040.014
Mouse
neuron projection regenerationGO:003110210.014
epithelium migrationGO:00901321190.014
regulation of reactive oxygen species metabolic processGO:2000377410.014
establishment of protein localization to membraneGO:00901501210.014
cell substrate adhesionGO:00315891320.014
t cell activationGO:0042110990.014
axon regenerationGO:003110310.014
lung alveolus developmentGO:004828640.014
epithelial cell proliferationGO:00506731280.014
positive regulation of cell cycleGO:00457871400.014
response to bacteriumGO:00096171440.014
tissue regenerationGO:004224630.014
positive regulation of cytoplasmic transportGO:1903651820.014
Mouse
response to hormoneGO:00097251750.014
single organismal cell cell adhesionGO:00163371480.014
transmission of nerve impulseGO:0019226110.014
modification dependent macromolecule catabolic processGO:00436322120.014
regulation of lymphocyte activationGO:00512491030.014
regulation of protein secretionGO:0050708860.014
forelimb morphogenesisGO:003513640.014
cellular response to organonitrogen compoundGO:00714171240.014
response to virusGO:00096151260.014
negative regulation of axonogenesisGO:005077140.014
positive regulation of cell projection organizationGO:0031346640.014
lens development in camera type eyeGO:000208820.014
specification of organ identityGO:001009230.014
embryonic epithelial tube formationGO:000183840.014
fatty acid metabolic processGO:00066311150.014
regulation of nervous system developmentGO:0051960880.014
actin filament based movementGO:0030048170.014

CAMK4 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:8634310.026
central nervous system diseaseDOID:3311860.026
disease of metabolismDOID:00146672950.023
musculoskeletal system diseaseDOID:172230.023
immune system diseaseDOID:29141550.022
inherited metabolic disorderDOID:6552420.020
sensory system diseaseDOID:00501552030.020
connective tissue diseaseDOID:651090.019
disease of cellular proliferationDOID:145661740.019
cancerDOID:1621670.019
eye and adnexa diseaseDOID:14921500.019
eye diseaseDOID:56141490.019
organ system cancerDOID:00506861640.018
bone diseaseDOID:0080001880.016
retinal diseaseDOID:56791180.016
neurodegenerative diseaseDOID:12891020.015
brain diseaseDOID:936730.014