Homo sapiens

69 known processes

NEK2

NIMA (never in mitosis gene a)-related kinase 2

(Aliases: HsPK21,NEK2A,NLK1)

NEK2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
mitotic cell cycle processGO:19030472860.602
Mouse Fly
microtubule organizing center organizationGO:0031023620.569
microtubule cytoskeleton organizationGO:00002261760.545
mitotic cell cycleGO:00002783260.542
Mouse Fly
spindle assemblyGO:0051225290.528
Mouse
cytokinesisGO:0000910960.524
regulation of cell cycleGO:00517263930.520
Fly
male meiosisGO:000714010.510
microtubule based processGO:00070172100.488
spindle organizationGO:0007051530.384
Mouse
spindle assembly involved in mitosisGO:0090307120.331
Mouse
centrosome organizationGO:0051297580.330
cytoskeleton dependent cytokinesisGO:0061640220.328
meiotic chromosome segregationGO:004513240.318
spindle stabilizationGO:004314640.317
regulation of mitotic cell cycleGO:00073461890.315
Fly
organelle assemblyGO:00709251760.308
Mouse
cellular macromolecular complex assemblyGO:00346223240.279
establishment of organelle localizationGO:0051656590.253
sister chromatid biorientationGO:003113420.244
nuclear divisionGO:00002801280.242
Mouse Fly
mitotic sister chromatid segregationGO:0000070530.242
Mouse
sister chromatid segregationGO:0000819540.239
Mouse
spindle elongationGO:005123140.236
cell divisionGO:00513011680.229
Fly
positive regulation of protein phosphorylationGO:00019343130.220
ubiquitin dependent protein catabolic processGO:00065112060.219
organelle localizationGO:0051640840.195
regulation of chromosome segregationGO:0051983440.192
microtubule polymerization or depolymerizationGO:0031109370.189
protein depolymerizationGO:0051261300.185
chromosome segregationGO:00070591140.184
cellular protein complex assemblyGO:00436231880.174
post embryonic developmentGO:000979120.157
negative regulation of organelle organizationGO:00106391260.152
protein polymerizationGO:0051258710.148
macromolecular complex disassemblyGO:0032984600.147
negative regulation of cellular component organizationGO:00511292350.144
mitotic nuclear divisionGO:00070671190.141
Mouse Fly
regulation of cell differentiationGO:00455953930.139
stem cell divisionGO:001714520.137
microtubule cytoskeleton organization involved in mitosisGO:1902850150.136
Mouse
single organism cellular localizationGO:19025803320.132
positive regulation of cell cycleGO:00457871400.132
dephosphorylationGO:00163112090.130
regulation of cell cycle processGO:00105642660.129
Fly
histone serine phosphorylationGO:003540440.126
microtubule polymerizationGO:0046785180.125
nucleoside triphosphate metabolic processGO:00091414220.121
regulation of microtubule based processGO:0032886740.119
microtubule based movementGO:0007018320.119
regulation of mitotic metaphase anaphase transitionGO:0030071260.118
nucleotide catabolic processGO:00091664080.117
negative regulation of mitotic metaphase anaphase transitionGO:0045841170.114
establishment of nucleus localizationGO:004002310.111
attachment of spindle microtubules to kinetochoreGO:0008608170.110
protein dephosphorylationGO:0006470810.106
organelle fissionGO:00482851490.105
Mouse Fly
peptidyl serine phosphorylationGO:00181051010.103
regulation of mitotic sister chromatid segregationGO:0033047270.102
cellular component disassemblyGO:0022411920.100
negative regulation of mitotic cell cycleGO:00459301020.098
cellular macromolecule catabolic processGO:00442653800.094
regulation of cell divisionGO:00513021160.093
Fly
proteolysis involved in cellular protein catabolic processGO:00516032440.092
attachment of mitotic spindle microtubules to kinetochoreGO:005131530.087
neurogenesisGO:00220081690.087
Zebrafish
purine nucleoside triphosphate metabolic processGO:00091444120.086
regulation of attachment of spindle microtubules to kinetochoreGO:005198890.084
negative regulation of cell sizeGO:004579230.084
ribonucleoside catabolic processGO:00424544060.083
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.081
positive regulation of organelle organizationGO:00106381950.081
anatomical structure formation involved in morphogenesisGO:00486462840.080
female gamete generationGO:000729220.078
negative regulation of catalytic activityGO:00430863350.077
organophosphate catabolic processGO:00464344300.076
regulation of transferase activityGO:00513383550.075
purine nucleoside monophosphate metabolic processGO:00091261860.075
regulation of spindle organizationGO:0090224100.074
negative regulation of cell cycleGO:00457861930.074
protein modification by small protein conjugationGO:00324463420.073
regulation of mitotic sister chromatid separationGO:0010965270.072
purine ribonucleoside triphosphate metabolic processGO:00092054110.071
ribonucleoside triphosphate metabolic processGO:00091994120.068
spindle midzone assemblyGO:005125540.068
regulation of mitosisGO:0007088630.068
Fly
protein complex disassemblyGO:0043241520.068
mitotic sister chromatid separationGO:0051306180.068
cellular component morphogenesisGO:00329893140.067
heart developmentGO:0007507950.066
mitotic spindle midzone assemblyGO:005125640.066
nucleoside monophosphate catabolic processGO:00091251590.065
oogenesisGO:004847720.065
regulation of cytoskeleton organizationGO:00514931770.065
positive regulation of cell divisionGO:0051781590.064
mitotic cell cycle phase transitionGO:00447721620.064
positive regulation of cell cycle processGO:00900681060.063
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic processGO:0031145250.062
nucleoside monophosphate metabolic processGO:00091231910.062
chromatin organizationGO:00063253510.062
ribonucleoside monophosphate metabolic processGO:00091611870.061
protein polyubiquitinationGO:00002091100.061
vesicle mediated transportGO:00161923710.061
maintenance of locationGO:00512351120.060
centrosome separationGO:005129930.060
metaphase plate congressionGO:0051310180.060
regulation of proteasomal protein catabolic processGO:0061136870.058
negative regulation of protein metabolic processGO:00512483910.058
positive regulation of mitosisGO:0045840250.058
nervous system developmentGO:00073992930.057
Zebrafish
positive regulation of protein kinase activityGO:00458601900.057
maintenance of location in cellGO:0051651620.057
purine ribonucleoside monophosphate catabolic processGO:00091691580.057
ribonucleoside monophosphate catabolic processGO:00091581580.056
microtubule anchoringGO:0034453240.056
negative regulation of cell differentiationGO:00455961710.055
regulation of cellular component movementGO:00512703340.055
regulation of protein kinase activityGO:00458592890.055
spindle checkpointGO:0031577260.054
negative regulation of cellular protein metabolic processGO:00322693530.054
embryo developmentGO:00097901230.053
Mouse
negative regulation of phosphatase activityGO:0010923610.053
somatic stem cell divisionGO:004810310.052
negative regulation of proteolysisGO:00458611320.051
peptidyl serine modificationGO:00182091060.050
negative regulation of programmed cell deathGO:00430693210.050
atp catabolic processGO:00062001570.050
regulation of meiotic cell cycleGO:005144540.050
purine ribonucleoside monophosphate metabolic processGO:00091671860.049
mitotic spindle elongationGO:000002240.049
regulation of microtubule cytoskeleton organizationGO:0070507610.049
cell developmentGO:00484683280.049
Zebrafish
nucleoside triphosphate catabolic processGO:00091433940.048
cell cycle phase transitionGO:00447701730.047
modification dependent macromolecule catabolic processGO:00436322120.046
proteasomal protein catabolic processGO:00104981760.046
atp metabolic processGO:00460341760.046
mitotic metaphase plate congressionGO:0007080140.046
nucleus localizationGO:005164710.046
mitotic centrosome separationGO:000710010.045
cell projection organizationGO:00300302520.045
peptidyl tyrosine dephosphorylationGO:0035335360.044
regulation of cellular amino acid metabolic processGO:000652160.044
neuroblast proliferationGO:000740540.044
ribonucleoside triphosphate catabolic processGO:00092033910.044
regulation of proteolysisGO:00301622930.044
mitotic cytokinesisGO:0000281190.043
protein localization to organelleGO:00333652800.043
nucleoside phosphate catabolic processGO:19012924120.043
regulation of cellular component biogenesisGO:00440872810.042
regulation of cellular protein catabolic processGO:1903362960.042
cytoplasmic transportGO:00164823790.042
purine ribonucleoside catabolic processGO:00461303980.042
positive regulation of cellular protein catabolic processGO:1903364370.042
small gtpase mediated signal transductionGO:0007264780.041
negative regulation of mitotic cell cycle phase transitionGO:1901991850.041
regenerationGO:003109940.041
protein processingGO:00164852260.040
reproductive processGO:00224141060.040
modification dependent protein catabolic processGO:00199412090.040
purine ribonucleoside triphosphate catabolic processGO:00092073910.040
stem cell differentiationGO:0048863930.039
chromosome separationGO:0051304230.039
regulation of protein processingGO:00706131500.038
cellular protein complex disassemblyGO:0043624360.038
regulation of protein maturationGO:19033171500.038
ribonucleotide catabolic processGO:00092614050.038
protein maturationGO:00516042330.038
regulation of bindingGO:00510981110.038
Mouse
endomembrane system organizationGO:00102561960.037
purine nucleoside triphosphate catabolic processGO:00091463920.036
positive regulation of cellular catabolic processGO:00313312840.036
intracellular protein transportGO:00068862700.036
regulation of cell cycle phase transitionGO:19019871260.035
regulation of cell migrationGO:00303342890.034
cell morphogenesisGO:00009022960.034
regulation of nuclear divisionGO:0051783650.034
Fly
regulation of cytokinesisGO:0032465450.033
metaphase anaphase transition of mitotic cell cycleGO:0007091210.033
regulation of dephosphorylationGO:0035303960.032
meiosis iGO:000712740.031
positive regulation of phosphorylationGO:00423273940.031
response to oxidative stressGO:00069791210.031
positive regulation of dna metabolic processGO:0051054730.030
tissue regenerationGO:004224630.030
negative regulation of cell divisionGO:0051782310.030
metaphase anaphase transition of cell cycleGO:0044784210.030
cellular protein catabolic processGO:00442572610.030
negative regulation of cell cycle processGO:00109481210.029
negative regulation of phosphorus metabolic processGO:00105632670.029
immune system developmentGO:00025201950.029
positive regulation of catabolic processGO:00098963100.029
positive regulation of cellular component organizationGO:00511303760.029
regulation of cellular response to stressGO:00801352440.029
regulation of sister chromatid segregationGO:0033045270.028
regulation of cellular ketone metabolic processGO:0010565500.028
negative regulation of phosphate metabolic processGO:00459362670.028
regulation of intracellular protein transportGO:00331571230.028
single organism membrane organizationGO:00448022680.028
actin filament based processGO:00300292240.028
regulation of cell motilityGO:20001452990.028
regulation of chromosome organizationGO:00330441030.027
centrosome cycleGO:0007098320.027
regulation of kinase activityGO:00435493140.027
positive regulation of mitotic cell cycleGO:0045931600.027
positive regulation of mitotic sister chromatid separationGO:190197060.027
canonical wnt signaling pathwayGO:00600701160.026
negative regulation of protein processingGO:00109551420.026
neuroblast divisionGO:005505710.026
cellular amino acid metabolic processGO:00065201160.026
endocytosisGO:00068971590.026
oocyte differentiationGO:000999420.025
regulation of locomotionGO:00400123290.025
positive regulation of cell differentiationGO:00455972110.025
cellular response to dna damage stimulusGO:00069743790.025
negative regulation of protein maturationGO:19033181420.025
reproductionGO:0000003630.025
regulation of cytoplasmic transportGO:19036491490.025
regulation of wnt signaling pathwayGO:00301111230.024
Fly
regulation of endopeptidase activityGO:00525481700.024
purine nucleoside catabolic processGO:00061523980.024
positive regulation of protein catabolic processGO:0045732750.024
regulation of protein catabolic processGO:00421761550.023
positive regulation of cardiac muscle cell proliferationGO:006004520.023
regulation of metaphase anaphase transition of cell cycleGO:1902099260.023
nucleocytoplasmic transportGO:00069131760.023
nuclear transportGO:00511691790.023
purine ribonucleoside metabolic processGO:00461284370.023
generation of neuronsGO:00486991520.023
Zebrafish
negative regulation of developmental processGO:00510932470.023
regulation of intracellular transportGO:00323861950.023
negative regulation of mitosisGO:0045839240.023
activation of protein kinase activityGO:0032147900.023
regulation of mitotic cell cycle phase transitionGO:19019901180.022
purine nucleoside monophosphate catabolic processGO:00091281580.022
meiotic nuclear divisionGO:0007126100.022
digestive tract morphogenesisGO:0048546560.022
glycosyl compound catabolic processGO:19016584130.021
negative regulation of dephosphorylationGO:0035305630.021
chromatin modificationGO:00165682980.021
single organism reproductive processGO:0044702980.021
purine ribonucleotide catabolic processGO:00091544040.021
microtubule depolymerizationGO:0007019180.021
negative regulation of microtubule polymerization or depolymerizationGO:0031111170.021
regulation of establishment of protein localizationGO:00702012420.021
negative regulation of hydrolase activityGO:00513461820.021
cell projection morphogenesisGO:00488581290.020
negative regulation of cell cycle phase transitionGO:1901988890.020
somatic muscle developmentGO:000752510.020
regulation of cell developmentGO:00602841610.020
positive regulation of cytokinesisGO:0032467290.020
protein targetingGO:00066051870.020
ras protein signal transductionGO:0007265730.020
negative regulation of cell deathGO:00605483450.020
circulatory system developmentGO:00723592620.020
tube morphogenesisGO:0035239950.020
cilium morphogenesisGO:0060271750.019
cell part morphogenesisGO:00329901370.019
cell growthGO:00160491600.019
dna conformation changeGO:00711031130.019
peptidyl threonine phosphorylationGO:0018107410.019
oocyte developmentGO:004859910.019
positive regulation of intracellular transportGO:00323881040.019
negative regulation of apoptotic processGO:00430663160.019
response to abiotic stimulusGO:00096283360.019
regulation of protein complex assemblyGO:00432541470.019
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.018
protein catabolic processGO:00301633250.018
negative regulation of mitotic sister chromatid separationGO:2000816170.018
regulation of peptidase activityGO:00525471800.018
dna recombinationGO:0006310770.018
positive regulation of protein transportGO:00512221350.018
cardiovascular system developmentGO:00723582620.018
epithelium developmentGO:00604292270.018
developmental process involved in reproductionGO:0003006660.018
cell projection assemblyGO:00300311260.017
anterior posterior axis specificationGO:000994820.017
immune responseGO:00069553070.017
positive regulation of chromosome organizationGO:2001252410.017
positive regulation of developmental processGO:00510943140.017
cell cycle g1 s phase transitionGO:0044843800.017
protein targeting to nucleusGO:00447441040.017
positive regulation of transportGO:00510503360.017
centrosome duplicationGO:0051298280.017
cell fate determinationGO:000170930.017
negative regulation of protein phosphorylationGO:00019331400.017
negative regulation of metaphase anaphase transition of cell cycleGO:1902100170.017
protein localization to chromosome centromeric regionGO:0071459120.016
regulation of phosphatase activityGO:0010921810.016
response to lipidGO:00339932060.016
positive regulation of cytoskeleton organizationGO:0051495830.016
purine nucleotide catabolic processGO:00061954050.016
wnt signaling pathwayGO:00160551560.016
Fly
regulation of nucleocytoplasmic transportGO:0046822980.016
positive regulation of proteolysisGO:00458621420.016
nuclear migrationGO:000709710.016
tube developmentGO:00352951250.016
regulation of cysteine type endopeptidase activityGO:20001161270.016
regulation of protein localizationGO:00328802960.016
positive regulation of attachment of spindle microtubules to kinetochoreGO:005198720.016
cellular amine metabolic processGO:0044106410.016
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052350.016
mitotic spindle organizationGO:0007052270.016
Mouse
spermatid differentiationGO:004851540.016
cellular ketone metabolic processGO:0042180800.015
positive regulation of kinase activityGO:00336742040.015
amine metabolic processGO:0009308440.015
cell cycle g2 m phase transitionGO:0044839430.015
positive regulation of transferase activityGO:00513472270.015
cell cell signalingGO:00072671550.015
nucleoside catabolic processGO:00091644080.015
growthGO:00400072020.014
positive regulation of chromosome segregationGO:005198490.014
protein importGO:00170381300.014
regulation of cellular amine metabolic processGO:0033238110.014
positive regulation of hydrolase activityGO:00513453310.014
developmental growthGO:0048589480.014
protein autophosphorylationGO:00467771230.014
positive regulation of cellular amino acid metabolic processGO:004576430.014
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.014
positive regulation of cytoplasmic transportGO:1903651820.014
regulation of cardiac muscle cell proliferationGO:006004340.013
neuron developmentGO:00486661130.013
Zebrafish
negative regulation of catabolic processGO:00098951040.013
membrane organizationGO:00610242920.013
response to biotic stimulusGO:00096072760.013
neuronal stem cell divisionGO:003644510.013
peptidyl threonine modificationGO:0018210450.013
peptidyl tyrosine phosphorylationGO:00181081700.013
negative regulation of chromosome organizationGO:2001251480.013
negative regulation of sister chromatid segregationGO:0033046170.013
cellular response to oxygen containing compoundGO:19017012760.013
blastocyst developmentGO:000182430.013
Mouse
regulation of double strand break repairGO:2000779220.013
hemopoiesisGO:00300971800.013
regulation of canonical wnt signaling pathwayGO:0060828880.013
apoptotic signaling pathwayGO:00971902680.013
negative regulation of methylation dependent chromatin silencingGO:009031020.013
receptor mediated endocytosisGO:0006898840.012
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.012
establishment of chromosome localizationGO:0051303200.012
negative regulation of cellular protein catabolic processGO:1903363380.012
response to woundingGO:00096111680.012
double strand break repair via homologous recombinationGO:0000724500.012
maintenance of protein locationGO:0045185570.012
protein ubiquitinationGO:00165673140.012
lysosomal transportGO:0007041330.012
multi organism reproductive processGO:0044703540.011
protein localization to nucleusGO:00345041360.011
purine containing compound catabolic processGO:00725234110.011
mitotic cell cycle checkpointGO:0007093680.011
negative regulation of cellular catabolic processGO:0031330830.011
regulation of protein dephosphorylationGO:0035304180.011
response to radiationGO:00093141510.011
response to organic cyclic compoundGO:00140702040.011
positive regulation of metaphase anaphase transition of cell cycleGO:190210160.011
positive regulation of nucleotide metabolic processGO:00459812300.011
muscle structure developmentGO:0061061980.011
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.011
multicellular organismal agingGO:001025930.011
regulation of protein import into nucleusGO:0042306780.011
regulation of ligase activityGO:0051340290.011
negative regulation of protein complex disassemblyGO:0043242200.011
dna packagingGO:0006323770.010
response to oxygen containing compoundGO:19017003690.010
reproductive system developmentGO:0061458560.010
regulation of mitotic spindle organizationGO:006023660.010
neuron differentiationGO:00301821380.010
Zebrafish
intrinsic apoptotic signaling pathwayGO:00971931270.010

NEK2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:1621670.047
disease of cellular proliferationDOID:145661740.047
gastrointestinal system cancerDOID:3119520.046
organ system cancerDOID:00506861640.046