Homo sapiens

74 known processes

SLX4

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

(Aliases: MUS312,FANCP,KIAA1987,KIAA1784,BTBD12)

SLX4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
nucleotide excision repair dna incisionGO:003368371.000
regulation of telomere maintenanceGO:0032204131.000
nucleotide excision repairGO:0006289310.999
negative regulation of telomere maintenanceGO:003220590.999
response to dna integrity checkpoint signalingGO:007240240.998
dna catabolic processGO:0006308490.998
cellular response to dna damage stimulusGO:00069743790.995
dna repairGO:00062811980.994
nucleic acid phosphodiester bond hydrolysisGO:00903051020.993
double strand break repair via homologous recombinationGO:0000724500.992
response to intra s dna damage checkpoint signalingGO:007242940.989
recombinational repairGO:0000725500.987
response to cell cycle checkpoint signalingGO:007239640.985
telomere organizationGO:0032200330.984
response to dna damage checkpoint signalingGO:007242340.965
telomere maintenanceGO:0000723320.964
negative regulation of homeostatic processGO:0032845590.957
negative regulation of chromosome organizationGO:2001251480.949
negative regulation of dna metabolic processGO:0051053570.949
dna catabolic process endonucleolyticGO:0000737370.942
anatomical structure homeostasisGO:00602491000.925
negative regulation of organelle organizationGO:00106391260.819
regulation of dna metabolic processGO:00510521530.816
regulation of chromosome organizationGO:00330441030.802
negative regulation of cellular component organizationGO:00511292350.776
cellular macromolecule catabolic processGO:00442653800.713
double strand break repairGO:00063021010.706
dna recombinationGO:0006310770.643
response to biotic stimulusGO:00096072760.638
regulation of cell cycle processGO:00105642660.543
cellular response to biotic stimulusGO:0071216710.469
sex determinationGO:000753030.461
regulation of homeostatic processGO:00328441210.451
regulation of mitotic cell cycleGO:00073461890.395
dna integrity checkpointGO:0031570710.283
positive regulation of telomere maintenanceGO:003220640.267
positive regulation of hydrolase activityGO:00513453310.260
negative regulation of cell cycleGO:00457861930.235
non recombinational repairGO:0000726140.233
purine ribonucleoside metabolic processGO:00461284370.225
purine ribonucleoside triphosphate catabolic processGO:00092073910.213
nucleoside triphosphate metabolic processGO:00091414220.210
response to uvGO:0009411730.200
protein localization to chromosome telomeric regionGO:007019860.197
mitotic cell cycle processGO:19030472860.180
morphogenesis of embryonic epitheliumGO:001633140.176
negative regulation of cell cycle processGO:00109481210.171
post embryonic developmentGO:000979120.165
mitotic cell cycleGO:00002783260.144
dna damage checkpointGO:0000077680.132
cellular protein complex assemblyGO:00436231880.131
guanosine containing compound metabolic processGO:19010682440.128
microtubule polymerizationGO:0046785180.125
purine ribonucleoside catabolic processGO:00461303980.117
response to radiationGO:00093141510.117
regulation of cell cycleGO:00517263930.113
mitotic cell cycle checkpointGO:0007093680.103
neural tube formationGO:000184130.098
negative regulation of mitotic cell cycle phase transitionGO:1901991850.098
negative regulation of mitotic cell cycleGO:00459301020.090
telomere maintenance via telomeraseGO:000700480.089
mitotic g2 dna damage checkpointGO:000709570.088
histone modificationGO:00165702510.086
purine ribonucleotide catabolic processGO:00091544040.086
nucleotide catabolic processGO:00091664080.082
response to light stimulusGO:0009416870.081
uv protectionGO:000965050.081
negative regulation of cell cycle phase transitionGO:1901988890.080
organic anion transportGO:00157111030.080
glycosyl compound catabolic processGO:19016584130.072
embryo developmentGO:00097901230.072
cellular response to endogenous stimulusGO:00714953360.072
nucleoside phosphate catabolic processGO:19012924120.072
dephosphorylationGO:00163112090.072
purine nucleotide catabolic processGO:00061954050.071
positive regulation of catabolic processGO:00098963100.069
modification dependent macromolecule catabolic processGO:00436322120.068
regulation of meiotic cell cycleGO:005144540.067
meiosis iGO:000712740.067
positive regulation of cell cycle processGO:00900681060.067
telomere maintenance via telomere lengtheningGO:001083390.065
ribonucleotide catabolic processGO:00092614050.064
negative regulation of catabolic processGO:00098951040.063
regulation of gtp catabolic processGO:00331241800.062
positive regulation of cell deathGO:00109422630.062
mitotic recombinationGO:000631280.060
mitochondrion organizationGO:00070051560.058
embryonic epithelial tube formationGO:000183840.058
g2 m transition of mitotic cell cycleGO:0000086410.058
response to woundingGO:00096111680.058
negative regulation of catalytic activityGO:00430863350.055
ribonucleoside triphosphate metabolic processGO:00091994120.054
protein localization to chromosomeGO:0034502300.053
cell cycle phase transitionGO:00447701730.052
protein maturationGO:00516042330.052
negative regulation of protein metabolic processGO:00512483910.050
positive regulation of programmed cell deathGO:00430682490.048
epithelium developmentGO:00604292270.047
protein localization to organelleGO:00333652800.047
ribonucleoside triphosphate catabolic processGO:00092033910.046
cell cycle g2 m phase transitionGO:0044839430.046
chromatin modificationGO:00165682980.046
regulation of cell cycle phase transitionGO:19019871260.045
mitotic dna integrity checkpointGO:0044774300.044
negative regulation of cellular catabolic processGO:0031330830.044
response to metal ionGO:0010038840.044
purine nucleoside catabolic processGO:00061523980.043
positive regulation of cellular amino acid metabolic processGO:004576430.043
primary neural tube formationGO:001402030.040
cellular amino acid metabolic processGO:00065201160.040
purine containing compound catabolic processGO:00725234110.040
regulation of meiosisGO:004002030.039
somatic recombination of immunoglobulin gene segmentsGO:001644740.039
nuclear divisionGO:00002801280.039
regulation of mitotic cell cycle phase transitionGO:19019901180.038
positive regulation of purine nucleotide metabolic processGO:19005442270.038
tube closureGO:006060630.036
transmembrane transportGO:00550853990.036
purine nucleoside triphosphate metabolic processGO:00091444120.036
response to other organismGO:00517072610.035
replicative cell agingGO:000130230.034
negative regulation of transferase activityGO:00513481240.034
protein oligomerizationGO:00512591730.034
proteolysis involved in cellular protein catabolic processGO:00516032440.034
gene conversionGO:003582210.033
organophosphate catabolic processGO:00464344300.032
response to oxidative stressGO:00069791210.032
protein homooligomerizationGO:00512601000.032
amine metabolic processGO:0009308440.032
regulation of purine nucleotide metabolic processGO:19005422640.032
dna catabolic process exonucleolyticGO:0000738170.032
multicellular organismal agingGO:001025930.032
cell type specific apoptotic processGO:00972851250.031
negative regulation of proteasomal protein catabolic processGO:1901799320.031
adaptive immune responseGO:0002250490.030
microtubule based processGO:00070172100.030
regulation of ras protein signal transductionGO:00465781550.030
negative regulation of cellular protein metabolic processGO:00322693530.030
positive regulation of apoptotic processGO:00430652460.030
mismatch repairGO:0006298150.029
negative regulation of dna replicationGO:0008156290.029
positive regulation of nucleoside metabolic processGO:00459791860.029
response to oxygen containing compoundGO:19017003690.029
microtubule cytoskeleton organizationGO:00002261760.028
mitotic cell cycle phase transitionGO:00447721620.028
regulation of telomere maintenance via telomeraseGO:003221060.028
oogenesisGO:004847720.028
positive regulation of mitotic cell cycleGO:0045931600.028
regulation of cellular ketone metabolic processGO:0010565500.028
negative regulation of phosphorus metabolic processGO:00105632670.027
determination of adult lifespanGO:000834020.027
organic acid transportGO:0015849650.027
covalent chromatin modificationGO:00165692540.026
reactive oxygen species metabolic processGO:0072593750.026
ubiquitin dependent protein catabolic processGO:00065112060.026
positive regulation of intracellular protein transportGO:0090316760.025
positive regulation of gtpase activityGO:00435471660.025
regulation of nucleotide metabolic processGO:00061402690.025
positive regulation of purine nucleotide catabolic processGO:00331231850.025
single organism cell adhesionGO:00986021790.024
gtp metabolic processGO:00460392390.024
positive regulation of cellular amine metabolic processGO:003324070.024
immune responseGO:00069553070.024
negative regulation of chromosome segregationGO:0051985180.023
purine ribonucleoside monophosphate catabolic processGO:00091691580.023
negative regulation of protein phosphorylationGO:00019331400.023
regulation of transferase activityGO:00513383550.023
regulation of microtubule cytoskeleton organizationGO:0070507610.023
single organismal cell cell adhesionGO:00163371480.023
regulation of nucleotide catabolic processGO:00308112050.023
positive regulation of nucleotide catabolic processGO:00308131850.023
neural tube closureGO:000184330.022
i kappab kinase nf kappab signalingGO:00072491660.022
protein ubiquitinationGO:00165673140.022
regulation of cytoskeleton organizationGO:00514931770.022
anion transportGO:00068201610.022
oocyte differentiationGO:000999420.022
actin filament based processGO:00300292240.022
regulation of cellular amino acid metabolic processGO:000652160.022
cellular response to radiationGO:0071478650.022
gtp catabolic processGO:00061842370.022
purine ribonucleoside triphosphate metabolic processGO:00092054110.022
female gamete generationGO:000729220.022
tissue regenerationGO:004224630.022
regulation of protein processingGO:00706131500.021
assembly of actomyosin apparatus involved in cytokinesisGO:000091210.021
negative regulation of telomere maintenance via telomeraseGO:003221150.021
negative regulation of protein modification processGO:00314002000.021
mitotic g2 m transition checkpointGO:004481890.021
negative regulation of mitotic metaphase anaphase transitionGO:0045841170.020
oocyte developmentGO:004859910.020
establishment or maintenance of apical basal cell polarityGO:003508820.020
regulation of protein kinase activityGO:00458592890.020
morphogenesis of a polarized epitheliumGO:000173830.019
spermatid developmentGO:000728640.019
cell activationGO:00017752130.019
positive regulation of nucleotide metabolic processGO:00459812300.019
positive regulation of cellular catabolic processGO:00313312840.019
nervous system developmentGO:00073992930.019
rho protein signal transductionGO:0007266260.019
cell divisionGO:00513011680.019
male meiosisGO:000714010.019
signal transduction by phosphorylationGO:00230142970.019
purine nucleoside monophosphate metabolic processGO:00091261860.019
salivary gland morphogenesisGO:000743540.018
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.018
organelle fissionGO:00482851490.018
intracellular protein transportGO:00068862700.018
carboxylic acid transportGO:0046942630.018
regulation of i kappab kinase nf kappab signalingGO:00431221620.018
single organism reproductive processGO:0044702980.018
immune effector processGO:00022521590.018
leukocyte activationGO:00453211640.018
glycoprotein metabolic processGO:00091001100.018
sequestering of calcium ionGO:0051208170.018
cell fate commitmentGO:0045165270.018
immune system developmentGO:00025201950.017
negative regulation of kinase activityGO:00336731060.017
protein processingGO:00164852260.017
cellular ketone metabolic processGO:0042180800.017
positive regulation of dna metabolic processGO:0051054730.017
positive regulation of mitosisGO:0045840250.017
regulation of proteasomal protein catabolic processGO:0061136870.017
segmentationGO:003528240.017
neuroblast proliferationGO:000740540.017
negative regulation of stem cell proliferationGO:200064730.017
cell agingGO:0007569520.017
somatic recombination of immunoglobulin genes involved in immune responseGO:000220430.017
developmental programmed cell deathGO:001062330.017
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.017
cellular amine metabolic processGO:0044106410.017
regulation of carbohydrate metabolic processGO:0006109540.017
spindle midzone assemblyGO:005125540.017
ribonucleoside catabolic processGO:00424544060.016
endosomal transportGO:00161971290.016
myosin filament assemblyGO:003103420.016
ion transmembrane transportGO:00342203380.016
nucleoside monophosphate metabolic processGO:00091231910.016
negative regulation of phosphorylationGO:00423261740.016
response to ionizing radiationGO:0010212650.016
purine nucleoside triphosphate catabolic processGO:00091463920.016
regulation of nucleoside metabolic processGO:00091182090.016
regulation of cellular protein catabolic processGO:1903362960.016
epithelial cell proliferationGO:00506731280.016
nucleoside triphosphate catabolic processGO:00091433940.015
regulation of cellular carbohydrate metabolic processGO:0010675470.015
regulation of kinase activityGO:00435493140.015
hematopoietic or lymphoid organ developmentGO:00485341860.015
nitrogen compound transportGO:00717051910.015
nucleoside catabolic processGO:00091644080.015
protein polymerizationGO:0051258710.015
negative regulation of jun kinase activityGO:004350840.015
chromatin organizationGO:00063253510.015
positive regulation of organelle organizationGO:00106381950.015
positive regulation of protein transportGO:00512221350.015
spermatid differentiationGO:004851540.015
developmental process involved in reproductionGO:0003006660.015
regenerationGO:003109940.015
tissue migrationGO:00901301190.015
protein methylationGO:0006479740.015
regulation of metaphase anaphase transition of cell cycleGO:1902099260.014
sequestering of metal ionGO:0051238240.014
regulation of mitotic metaphase anaphase transitionGO:0030071260.014
positive regulation of cell cycleGO:00457871400.014
cellular component disassemblyGO:0022411920.014
negative regulation of phosphate metabolic processGO:00459362670.014
release of cytoplasmic sequestered nf kappabGO:000858840.014
negative regulation of programmed cell deathGO:00430693210.014
wound healingGO:00420601150.014
regulation of phosphatase activityGO:0010921810.014
negative regulation of neural precursor cell proliferationGO:200017810.014
single organism membrane organizationGO:00448022680.014
midgut developmentGO:000749410.014
ribonucleoside monophosphate metabolic processGO:00091611870.014
agingGO:0007568660.014
nucleus organizationGO:0006997280.014
lymphocyte activationGO:00466491330.014
regulation of establishment of protein localizationGO:00702012420.014
regulation of microtubule based processGO:0032886740.014
regulation of purine nucleotide catabolic processGO:00331212050.014
hemostasisGO:0007599760.014
actin filament based movementGO:0030048170.014
morphogenesis of an epitheliumGO:0002009600.014
reproductive processGO:00224141060.014
anatomical structure formation involved in morphogenesisGO:00486462840.014
apoptotic process involved in morphogenesisGO:006056130.014
vesicle mediated transportGO:00161923710.014
negative regulation of protein kinase activityGO:0006469980.014
actin cytoskeleton organizationGO:00300362070.013
negative regulation of intracellular signal transductionGO:19025321830.013
purine nucleotide biosynthetic processGO:0006164840.013
positive regulation of chromosome organizationGO:2001252410.013
neurotransmitter secretionGO:000726940.013
negative regulation of gliogenesisGO:001401430.013
regulation of cellular amine metabolic processGO:0033238110.013
rna processingGO:00063962550.013
mitochondrial rna metabolic processGO:0000959150.013
organonitrogen compound biosynthetic processGO:19015662000.013
negative regulation of dna recombinationGO:004591060.013
epithelium migrationGO:00901321190.013
regulation of neuroblast proliferationGO:190269230.013
cytokinesisGO:0000910960.013
negative regulation of epithelial cell proliferationGO:0050680480.012
mrna metabolic processGO:00160711750.012
cellular response to organic cyclic compoundGO:00714071270.012
regulation of growthGO:00400081650.012
regulation of mitotic sister chromatid separationGO:0010965270.012
establishment of protein localization to organelleGO:00725941720.012
organelle inheritanceGO:004830820.012
protein dephosphorylationGO:0006470810.012
positive regulation of apoptotic signaling pathwayGO:2001235700.012
negative regulation of mitotic sister chromatid separationGO:2000816170.012
positive regulation of gtp catabolic processGO:00331261660.012
regulation of cellular component biogenesisGO:00440872810.012
regulation of neural precursor cell proliferationGO:200017740.012
macromolecule glycosylationGO:0043413630.012
nuclear transportGO:00511691790.012
proteasomal protein catabolic processGO:00104981760.012
protein glycosylationGO:0006486620.012
regulation of small gtpase mediated signal transductionGO:00510561560.012
organelle assemblyGO:00709251760.012
protein catabolic processGO:00301633250.012
regulation of gtpase activityGO:00430871800.012
ameboidal type cell migrationGO:00016671350.012
activation of mitotic anaphase promoting complex activityGO:000709220.012
positive regulation of protein phosphorylationGO:00019343130.012
positive regulation of transferase activityGO:00513472270.012
organ morphogenesisGO:00098871470.011
dna replicationGO:00062601160.011
membrane organizationGO:00610242920.011
guanosine containing compound catabolic processGO:19010692390.011
cell matrix adhesionGO:0007160850.011
inner ear morphogenesisGO:004247240.011
regulation of cell migrationGO:00303342890.011
retrograde transport endosome to golgiGO:0042147450.011
negative regulation of protein serine threonine kinase activityGO:0071901570.011
thymus developmentGO:004853830.011
regulation of rho protein signal transductionGO:0035023790.011
mitotic dna damage checkpointGO:0044773280.011
negative regulation of cellular amino acid metabolic processGO:004576320.011
regulation of protein catabolic processGO:00421761550.011
protein localization to adherens junctionGO:007189620.011
myeloid leukocyte differentiationGO:0002573600.011
regulation of cell divisionGO:00513021160.011
purine nucleoside monophosphate catabolic processGO:00091281580.011
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.011
regulation of dephosphorylationGO:0035303960.011
positive regulation of ras gtpase activityGO:00323201170.011
epithelial cell differentiationGO:00308551410.011
protein polyubiquitinationGO:00002091100.011
positive regulation of cell proliferationGO:00082843010.011
cellular response to cytokine stimulusGO:00713451810.011
engulfment of apoptotic cellGO:004365220.010
regulation of cellular response to stressGO:00801352440.010
positive regulation of nuclear divisionGO:0051785270.010
protein localization to cell junctionGO:190241430.010
somatic hypermutation of immunoglobulin genesGO:001644610.010
positive regulation of proteolysisGO:00458621420.010
regulation of proteolysisGO:00301622930.010
negative regulation of hydrolase activityGO:00513461820.010
endocytosisGO:00068971590.010
mitotic spindle assembly checkpointGO:0007094140.010
establishment of planar polarityGO:000173630.010
mitochondrial transportGO:0006839600.010
regulation of protein transportGO:00512232130.010

SLX4 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
xeroderma pigmentosumDOID:005042780.968
immune system diseaseDOID:29141550.749
hematopoietic system diseaseDOID:741000.749
anemiaDOID:2355550.667
aplastic anemiaDOID:12449300.667
bone marrow diseaseDOID:4961310.667
inherited metabolic disorderDOID:6552420.110
disease of metabolismDOID:00146672950.110
musculoskeletal system diseaseDOID:172230.029
connective tissue diseaseDOID:651090.029
bone development diseaseDOID:0080006550.018
bone diseaseDOID:0080001880.018
amino acid metabolic disorderDOID:9252500.016
disease of cellular proliferationDOID:145661740.015
nervous system diseaseDOID:8634310.014
sensory system diseaseDOID:00501552030.014
artery diseaseDOID:0050828230.014
cardiovascular system diseaseDOID:12871060.014
vascular diseaseDOID:178250.014
osteochondrodysplasiaDOID:2256350.012
central nervous system diseaseDOID:3311860.011
congenital hypoplastic anemiaDOID:1342260.004
fanconi s anemiaDOID:13636160.004