Homo sapiens

207 known processes

TESC

tescalcin

(Aliases: FLJ20607,TSC,CHP3)

TESC biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of multicellular organismal processGO:00512413170.189
meiotic chromosome segregationGO:004513240.138
cell developmentGO:00484683280.087
cellular amine metabolic processGO:0044106410.086
cellular amino acid metabolic processGO:00065201160.081
negative regulation of developmental processGO:00510932470.075
post embryonic developmentGO:000979120.072
amine metabolic processGO:0009308440.067
regulation of cellular amine metabolic processGO:0033238110.067
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.065
chromatin modificationGO:00165682980.064
regulation of cellular ketone metabolic processGO:0010565500.063
regulation of cell developmentGO:00602841610.058
regulation of cellular amino acid metabolic processGO:000652160.058
positive regulation of cellular amino acid metabolic processGO:004576430.052
nervous system developmentGO:00073992930.050
chemical homeostasisGO:00488783060.049
Human
cellular ketone metabolic processGO:0042180800.049
negative regulation of cell differentiationGO:00455961710.049
chromatin organizationGO:00063253510.046
generation of neuronsGO:00486991520.044
multicellular organismal agingGO:001025930.044
metal ion transportGO:00300012720.044
chromosome segregationGO:00070591140.044
neuron differentiationGO:00301821380.039
negative regulation of cellular protein metabolic processGO:00322693530.038
system processGO:00030083490.038
regulation of cellular component movementGO:00512703340.038
negative regulation of cell developmentGO:0010721480.037
negative regulation of neuron differentiationGO:0045665210.036
negative regulation of programmed cell deathGO:00430693210.036
negative regulation of protein metabolic processGO:00512483910.036
negative regulation of catalytic activityGO:00430863350.036
Human Mouse
cation transportGO:00068123310.035
positive regulation of cellular component organizationGO:00511303760.034
locomotory behaviorGO:000762610.034
positive regulation of cellular amine metabolic processGO:003324070.034
oogenesisGO:004847720.034
lipid metabolic processGO:00066293810.034
biological adhesionGO:00226103310.034
ion homeostasisGO:00508012300.033
Human
negative regulation of apoptotic processGO:00430663160.033
defense responseGO:00069523150.033
regulation of proteolysisGO:00301622930.033
positive regulation of immune system processGO:00026842830.033
ion transmembrane transportGO:00342203380.033
female gamete generationGO:000729220.033
cytokine productionGO:00018162470.032
ras protein signal transductionGO:0007265730.032
regulation of cell motilityGO:20001452990.032
organelle fissionGO:00482851490.032
inorganic cation transmembrane transportGO:00986621940.031
positive regulation of transportGO:00510503360.031
nuclear divisionGO:00002801280.031
organophosphate catabolic processGO:00464344300.030
response to oxygen containing compoundGO:19017003690.030
regulation of cytokine productionGO:00018172320.029
negative regulation of cell deathGO:00605483450.029
negative regulation of cellular amine metabolic processGO:003323930.029
apoptotic signaling pathwayGO:00971902680.029
anatomical structure formation involved in morphogenesisGO:00486462840.028
determination of adult lifespanGO:000834020.028
protein processingGO:00164852260.028
segmentationGO:003528240.028
positive regulation of hydrolase activityGO:00513453310.028
Human
neurogenesisGO:00220081690.028
positive regulation of phosphorylationGO:00423273940.027
symbiosis encompassing mutualism through parasitismGO:00444031560.027
cell morphogenesisGO:00009022960.027
regulation of anatomical structure morphogenesisGO:00226032860.027
immune responseGO:00069553070.027
positive regulation of apoptotic processGO:00430652460.027
cation homeostasisGO:00550801890.027
Human
regulation of protein kinase activityGO:00458592890.026
negative regulation of phosphorus metabolic processGO:00105632670.026
Human
positive regulation of protein phosphorylationGO:00019343130.026
regulation of locomotionGO:00400123290.025
single organism membrane organizationGO:00448022680.025
transmembrane transportGO:00550853990.025
regulation of cell migrationGO:00303342890.025
cellular component morphogenesisGO:00329893140.025
regulation of kinase activityGO:00435493140.025
positive regulation of cell deathGO:00109422630.025
regulation of cell differentiationGO:00455953930.025
protein maturationGO:00516042330.025
cellular response to endogenous stimulusGO:00714953360.025
cell activationGO:00017752130.025
positive regulation of programmed cell deathGO:00430682490.025
cellular lipid metabolic processGO:00442553030.025
cellular macromolecule catabolic processGO:00442653800.024
nucleoside phosphate catabolic processGO:19012924120.024
vesicle mediated transportGO:00161923710.024
regulation of nucleotide metabolic processGO:00061402690.024
innate immune responseGO:00450871780.024
cardiac muscle cell contractionGO:008600340.024
positive regulation of catabolic processGO:00098963100.024
cellular response to oxygen containing compoundGO:19017012760.024
immune system developmentGO:00025201950.024
positive regulation of nucleotide metabolic processGO:00459812300.024
negative regulation of neurogenesisGO:0050768260.023
purine ribonucleoside metabolic processGO:00461284370.023
nucleoside triphosphate metabolic processGO:00091414220.023
cell projection organizationGO:00300302520.023
regulation of cellular response to stressGO:00801352440.023
secretion by cellGO:00329402260.023
purine ribonucleoside triphosphate catabolic processGO:00092073910.022
mapk cascadeGO:00001652880.022
purine ribonucleoside triphosphate metabolic processGO:00092054110.022
membrane organizationGO:00610242920.022
cell cell signalingGO:00072671550.022
cellular homeostasisGO:00197251960.022
Human
ribonucleoside triphosphate catabolic processGO:00092033910.022
cardiovascular system developmentGO:00723582620.022
ribonucleoside catabolic processGO:00424544060.022
response to external biotic stimulusGO:00432072610.022
oxidation reduction processGO:00551143960.022
response to other organismGO:00517072610.022
inorganic ion transmembrane transportGO:00986602310.022
dephosphorylationGO:00163112090.021
Human Mouse
neuromuscular junction developmentGO:000752830.021
mitotic cell cycleGO:00002783260.021
purine nucleoside catabolic processGO:00061523980.021
single organism carbohydrate metabolic processGO:00447231930.021
positive regulation of developmental processGO:00510943140.021
purine nucleoside triphosphate catabolic processGO:00091463920.021
organonitrogen compound biosynthetic processGO:19015662000.021
purine nucleoside triphosphate metabolic processGO:00091444120.021
ribonucleoside triphosphate metabolic processGO:00091994120.021
photoreceptor cell differentiationGO:004653020.020
cytoplasmic transportGO:00164823790.020
Human
regulation of purine nucleotide metabolic processGO:19005422640.020
divalent inorganic cation transportGO:00725111580.020
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.020
purine containing compound catabolic processGO:00725234110.020
multi organism cellular processGO:00447641560.020
regulation of protein localizationGO:00328802960.020
Human
regulation of transferase activityGO:00513383550.020
response to cytokineGO:00340972320.020
cellular protein catabolic processGO:00442572610.020
negative regulation of cellular amino acid metabolic processGO:004576320.020
negative regulation of phosphate metabolic processGO:00459362670.020
Human
small gtpase mediated signal transductionGO:0007264780.020
regulation of apoptotic signaling pathwayGO:20012331750.020
regulation of protein processingGO:00706131500.020
response to abiotic stimulusGO:00096283360.020
positive regulation of cell proliferationGO:00082843010.020
Human
hemopoiesisGO:00300971800.019
regulation of protein maturationGO:19033171500.019
viral processGO:00160321460.019
negative regulation of cellular component organizationGO:00511292350.019
regulation of multi organism processGO:00439001570.019
actin filament based processGO:00300292240.019
hindbrain developmentGO:003090230.019
negative regulation of cell proliferationGO:00082852280.019
positive regulation of cytokine productionGO:00018191670.019
peripheral nervous system developmentGO:000742220.019
positive regulation of cell differentiationGO:00455972110.019
regulation of neuron differentiationGO:0045664700.019
blood vessel developmentGO:00015681720.019
regulation of peptidase activityGO:00525471800.019
calcium ion transportGO:00068161470.019
cellular response to cytokine stimulusGO:00713451810.019
positive regulation of purine nucleotide metabolic processGO:19005442270.019
neurological system processGO:00508771630.019
ribonucleotide catabolic processGO:00092614050.019
negative regulation of hydrolase activityGO:00513461820.019
Human
regenerationGO:003109940.019
interspecies interaction between organismsGO:00444191560.018
reactive oxygen species metabolic processGO:0072593750.018
positive regulation of cellular catabolic processGO:00313312840.018
regulation of cell cycle processGO:00105642660.018
purine ribonucleotide catabolic processGO:00091544040.018
oocyte developmentGO:004859910.018
organophosphate biosynthetic processGO:00904071630.018
cellular response to growth factor stimulusGO:00713631970.018
rho protein signal transductionGO:0007266260.018
regulation of sequence specific dna binding transcription factor activityGO:00510902110.018
Human
purine ribonucleoside catabolic processGO:00461303980.018
proteolysis involved in cellular protein catabolic processGO:00516032440.018
blood vessel morphogenesisGO:00485141620.018
secretionGO:00469032540.018
signal transduction by phosphorylationGO:00230142970.018
response to organic cyclic compoundGO:00140702040.018
adult locomotory behaviorGO:000834410.018
cation transmembrane transportGO:00986552380.018
angiogenesisGO:00015251470.018
enzyme linked receptor protein signaling pathwayGO:00071673030.018
nucleoside triphosphate catabolic processGO:00091433940.018
intracellular protein transportGO:00068862700.018
metal ion homeostasisGO:00550651690.018
histone modificationGO:00165702510.018
protein localization to organelleGO:00333652800.018
Human
circulatory system developmentGO:00723592620.018
lipid biosynthetic processGO:00086101770.018
memoryGO:000761330.018
cell proliferation involved in heart valve developmentGO:200079310.018
anterior posterior axis specificationGO:000994820.018
monocarboxylic acid metabolic processGO:00327871850.018
spermatid developmentGO:000728640.018
positive regulation of organelle organizationGO:00106381950.017
cellular response to dna damage stimulusGO:00069743790.017
cellular macromolecular complex assemblyGO:00346223240.017
cellular ion homeostasisGO:00068731680.017
Human
positive regulation of cell motilityGO:20001471770.017
carbohydrate metabolic processGO:00059752070.017
negative regulation of protein modification processGO:00314002000.017
nucleoside catabolic processGO:00091644080.017
regulation of immune responseGO:00507762010.017
glycosyl compound catabolic processGO:19016584130.017
negative regulation of phosphorylationGO:00423261740.017
ameboidal type cell migrationGO:00016671350.017
positive regulation of cell migrationGO:00303351720.017
regulation of protein transportGO:00512232130.016
Human
positive regulation of transferase activityGO:00513472270.016
divalent metal ion transportGO:00708381520.016
regulation of cellular component biogenesisGO:00440872810.016
oocyte differentiationGO:000999420.016
cell fate determinationGO:000170930.016
response to inorganic substanceGO:00100351270.016
Human
organic hydroxy compound metabolic processGO:19016151470.016
regulation of secretion by cellGO:19035301770.016
cell adhesionGO:00071553250.016
blastoderm segmentationGO:000735020.016
regulation of cell cycleGO:00517263930.016
morphogenesis of embryonic epitheliumGO:001633140.016
mitochondrion organizationGO:00070051560.016
response to biotic stimulusGO:00096072760.016
regulation of viral processGO:00507921030.016
carbohydrate derivative biosynthetic processGO:19011372070.016
negative regulation of protein phosphorylationGO:00019331400.016
small molecule biosynthetic processGO:00442831570.016
protein localization to membraneGO:00726571600.016
regulation of response to external stimulusGO:00321012220.016
cell cycle phase transitionGO:00447701730.016
microtubule based processGO:00070172100.016
response to growth factorGO:00708482050.016
nitrogen compound transportGO:00717051910.016
cellular chemical homeostasisGO:00550821800.016
Human
glycoprotein metabolic processGO:00091001100.016
negative regulation of cell cycleGO:00457861930.016
actin mediated cell contractionGO:0070252120.016
response to bacteriumGO:00096171440.015
purine nucleotide catabolic processGO:00061954050.015
epithelial cell migrationGO:00106311190.015
negative regulation of protein maturationGO:19033181420.015
nucleotide catabolic processGO:00091664080.015
posttranscriptional regulation of gene expressionGO:00106082130.015
regulation of secretionGO:00510461940.015
organ formationGO:004864530.015
actin filament based movementGO:0030048170.015
guanosine containing compound catabolic processGO:19010692390.015
positive regulation of nucleoside metabolic processGO:00459791860.015
regulation of establishment of protein localizationGO:00702012420.015
Human
matingGO:000761810.015
metencephalon developmentGO:002203720.015
rna splicingGO:00083801310.015
regulation of purine nucleotide catabolic processGO:00331212050.015
response to nitrogen compoundGO:19016981840.015
negative regulation of intracellular signal transductionGO:19025321830.015
Human
covalent chromatin modificationGO:00165692540.015
regulation of intracellular transportGO:00323861950.015
Human
cellular cation homeostasisGO:00300031630.015
Human
cell growthGO:00160491600.015
negative regulation of protein processingGO:00109551420.015
associative learningGO:000830610.015
regulation of neural precursor cell proliferationGO:200017740.015
single organism cell adhesionGO:00986021790.015
positive regulation of purine nucleotide catabolic processGO:00331231850.015
regulation of mitotic cell cycleGO:00073461890.015
cellular response to oxidative stressGO:0034599850.014
spermatid differentiationGO:004851540.014
tripartite regional subdivisionGO:000735120.014
positive regulation of cellular component movementGO:00512721810.014
maintenance of locationGO:00512351120.014
cellular metal ion homeostasisGO:00068751460.014
regulation of synaptic plasticityGO:004816730.014
negative regulation of proteolysisGO:00458611320.014
regulation of feeding behaviorGO:006025930.014
regulation of small gtpase mediated signal transductionGO:00510561560.014
reactive oxygen species biosynthetic processGO:190340940.014
embryonic epithelial tube formationGO:000183840.014
peptidyl tyrosine phosphorylationGO:00181081700.014
limbic system developmentGO:002176130.014
regulation of nucleotide catabolic processGO:00308112050.014
positive regulation of gtpase activityGO:00435471660.014
regulation of vasculature developmentGO:1901342970.014
cell type specific apoptotic processGO:00972851250.014
reactive nitrogen species metabolic processGO:200105730.014
mitotic cell cycle processGO:19030472860.014
regulation of cell growthGO:00015581350.014
endomembrane system organizationGO:00102561960.014
negative regulation of cellular component movementGO:00512711060.014
organic acid biosynthetic processGO:0016053970.014
sequestering of metal ionGO:0051238240.014
hematopoietic or lymphoid organ developmentGO:00485341860.014
carboxylic acid biosynthetic processGO:0046394970.014
vasculature developmentGO:00019441810.014
regulation of endopeptidase activityGO:00525481700.014
protein oligomerizationGO:00512591730.014
somatic stem cell maintenanceGO:003501940.014
canonical wnt signaling pathwayGO:00600701160.014
retinal ganglion cell axon guidanceGO:003129020.014
i kappab kinase nf kappab signalingGO:00072491660.014
anion transportGO:00068201610.014
neuroblast proliferationGO:000740540.013
single organismal cell cell adhesionGO:00163371480.013
gtp metabolic processGO:00460392390.013
syncytium formation by plasma membrane fusionGO:000076820.013
extrinsic apoptotic signaling pathwayGO:00971911190.013
modification dependent macromolecule catabolic processGO:00436322120.013
rna processingGO:00063962550.013
anterior posterior axis specification embryoGO:000859520.013
regulation of gtpase activityGO:00430871800.013
positive regulation of nucleotide catabolic processGO:00308131850.013
regulation of homeostatic processGO:00328441210.013
regulation of cysteine type endopeptidase activityGO:20001161270.013
calcium ion homeostasisGO:00550741220.013
response to decreased oxygen levelsGO:0036293960.013
cellular divalent inorganic cation homeostasisGO:00725031280.013
growthGO:00400072020.013
cell part morphogenesisGO:00329901370.013
protein catabolic processGO:00301633250.013
cell substrate adhesionGO:00315891320.013
regulation of cytoplasmic transportGO:19036491490.013
Human
regulation of protein serine threonine kinase activityGO:00719001790.013
negative regulation of locomotionGO:00400131180.013
proteasomal protein catabolic processGO:00104981760.013
spinal cord developmentGO:002151040.013
positive regulation of locomotionGO:00400171860.013
actin cytoskeleton organizationGO:00300362070.013
regulation of nucleoside metabolic processGO:00091182090.013
negative regulation of transportGO:00510511760.013
Human
tissue migrationGO:00901301190.013
positive regulation of cellular component biogenesisGO:00440891580.013
circulatory system processGO:00030131130.013
regulation of dna metabolic processGO:00510521530.013
wnt signaling pathwayGO:00160551560.013
visual behaviorGO:000763220.013
positive regulation of proteolysisGO:00458621420.013
regulation of cell adhesionGO:00301551660.013
regulation of protein catabolic processGO:00421761550.012
cerebellum developmentGO:002154920.012
regulation of reactive oxygen species metabolic processGO:2000377410.012
salivary gland morphogenesisGO:000743540.012
guanosine containing compound metabolic processGO:19010682440.012
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.012
regulation of hormone levelsGO:00108171250.012
sequestering of calcium ionGO:0051208170.012
neuron fate commitmentGO:004866320.012
gastrulation with mouth forming secondGO:000170210.012
modification dependent protein catabolic processGO:00199412090.012
monovalent inorganic cation transportGO:00156721280.012
gtp catabolic processGO:00061842370.012
g protein coupled receptor signaling pathwayGO:00071862070.012
sex determinationGO:000753030.012
negative regulation of transferase activityGO:00513481240.012
positive regulation of ion transportGO:0043270870.012
immune effector processGO:00022521590.012
positive regulation of gtp catabolic processGO:00331261660.012
chemotaxisGO:00069351570.012
response to hypoxiaGO:0001666960.012
regulation of meiotic cell cycleGO:005144540.012
response to oxygen levelsGO:00704821000.012
divalent inorganic cation homeostasisGO:00725071360.012
compound eye developmentGO:004874910.012
leukocyte activationGO:00453211640.012
negative regulation of organelle organizationGO:00106391260.012
positive regulation of neural precursor cell proliferationGO:200017920.012
muscle contractionGO:0006936730.012
regulation of protein complex assemblyGO:00432541470.012
regulation of gtp catabolic processGO:00331241800.012
response to woundingGO:00096111680.012
regulation of peptidyl tyrosine phosphorylationGO:00507301080.012
regulation of growthGO:00400081650.012
small molecule catabolic processGO:0044282920.012
protein acylationGO:00435431380.012
sulfur compound metabolic processGO:00067901010.012
epithelial cell proliferationGO:00506731280.012
regulation of transporter activityGO:0032409820.012
positive regulation of immune responseGO:00507781590.012
regulation of membrane potentialGO:0042391950.012
rna interferenceGO:001624640.012
single organism cellular localizationGO:19025803320.012
negative regulation of peptidase activityGO:0010466910.012
rhythmic behaviorGO:000762220.012
positive regulation of synaptic transmissionGO:005080640.012
regulation of cell activationGO:00508651250.012
blood circulationGO:00080151130.012
atrioventricular valve developmentGO:000317130.012
response to organonitrogen compoundGO:00102431560.012
regulation of epithelial cell proliferationGO:00506781130.012
stem cell divisionGO:001714520.012
response to axon injuryGO:004867810.012
positive regulation of kinase activityGO:00336742040.012
circadian behaviorGO:004851220.011
somitogenesisGO:000175620.011
muscle system processGO:0003012810.011
mrna metabolic processGO:00160711750.011
lung alveolus developmentGO:004828640.011
regulation of ras protein signal transductionGO:00465781550.011
cellular calcium ion homeostasisGO:00068741170.011
response to fungusGO:000962040.011
cofactor metabolic processGO:0051186870.011
regulation of mapk cascadeGO:00434082620.011
fatty acid metabolic processGO:00066311150.011
regulation of ion transportGO:00432691890.011
negative regulation of nervous system developmentGO:0051961280.011
positive regulation of protein serine threonine kinase activityGO:00719021190.011
epithelium developmentGO:00604292270.011
nerve developmentGO:002167540.011
ubiquitin dependent protein catabolic processGO:00065112060.011
regulation of cytoskeleton organizationGO:00514931770.011
response to hormoneGO:00097251750.011
phospholipid metabolic processGO:0006644990.011
peptidyl lysine acetylationGO:00183941010.011
response to radiationGO:00093141510.011
protein localization to plasma membraneGO:0072659930.011
negative regulation of apoptotic signaling pathwayGO:2001234970.011
striated muscle contractionGO:0006941520.011
epithelium migrationGO:00901321190.011
central nervous system developmentGO:00074171230.011
leukocyte differentiationGO:0002521980.011
glial cell migrationGO:000834740.011
morphogenesis of a polarized epitheliumGO:000173830.011
nuclear transportGO:00511691790.011
Human
regulation of metal ion transportGO:00109591200.011
regulation of glial cell differentiationGO:004568530.011
tube closureGO:006060630.011
regulation of dephosphorylationGO:0035303960.011
Human
negative regulation of endopeptidase activityGO:0010951840.011
plasma membrane organizationGO:00070091150.011
peptidyl lysine modificationGO:00182051440.011
tissue regenerationGO:004224630.011
positive regulation of reactive oxygen species metabolic processGO:2000379240.011
purine nucleoside monophosphate metabolic processGO:00091261860.011
negative regulation of growthGO:0045926970.011
inner ear morphogenesisGO:004247240.011
positive regulation of reactive oxygen species biosynthetic processGO:190342820.011
forebrain generation of neuronsGO:002187230.011
negative regulation of synaptic transmissionGO:005080520.011
nucleoside monophosphate metabolic processGO:00091231910.011
sensory perception of painGO:001923340.011
neural tube formationGO:000184130.011
cellular response to external stimulusGO:00714961110.011
regulation of actin filament based processGO:00329701410.011
peptidyl tyrosine modificationGO:00182121700.011
positive regulation of secretionGO:00510471160.011
sensory perception of smellGO:000760820.011
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.011
cellular response to organonitrogen compoundGO:00714171240.011
regulation of wnt signaling pathwayGO:00301111230.011
t cell differentiation in thymusGO:003307740.011
mrna processingGO:00063971330.011
melanin metabolic processGO:000658210.010
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.010
cardiac muscle contractionGO:0060048340.010
cell morphogenesis involved in differentiationGO:00009041440.010
cell projection morphogenesisGO:00488581290.010
myoblast fusionGO:000752010.010
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.010
eye photoreceptor cell differentiationGO:000175420.010
head developmentGO:00603221080.010
nucleotide biosynthetic processGO:00091651090.010
endothelial cell migrationGO:0043542860.010
nucleocytoplasmic transportGO:00069131760.010
Human
regulation of defense responseGO:00313471540.010
response to virusGO:00096151260.010
cellular carbohydrate metabolic processGO:0044262840.010
protein autophosphorylationGO:00467771230.010
neurotransmitter secretionGO:000726940.010
myeloid cell differentiationGO:00300991170.010
regulation of bindingGO:00510981110.010
cellular amide metabolic processGO:0043603690.010
regulation of i kappab kinase nf kappab signalingGO:00431221620.010

TESC disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.036
inherited metabolic disorderDOID:6552420.023
immune system diseaseDOID:29141550.022
musculoskeletal system diseaseDOID:172230.022
sensory system diseaseDOID:00501552030.016
nervous system diseaseDOID:8634310.016
central nervous system diseaseDOID:3311860.016
connective tissue diseaseDOID:651090.016
cancerDOID:1621670.015
disease of cellular proliferationDOID:145661740.015
organ system cancerDOID:00506861640.015
neurodegenerative diseaseDOID:12891020.015
eye diseaseDOID:56141490.013
eye and adnexa diseaseDOID:14921500.013
bone diseaseDOID:0080001880.013
hematopoietic system diseaseDOID:741000.012
retinal diseaseDOID:56791180.011
muscular diseaseDOID:00800001140.011
muscle tissue diseaseDOID:661130.011