Homo sapiens

0 known processes

KRT37

keratin 37

(Aliases: hHa7,KRTHA7,HA7)

KRT37 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
golgi to plasma membrane cftr protein transportGO:004300010.163
Human
ion transmembrane transportGO:00342203380.155
positive regulation of phosphorylationGO:00423273940.093
intermediate filament based processGO:0045103170.089
Human
cation transportGO:00068123310.089
keratinizationGO:003142420.083
negative regulation of cell deathGO:00605483450.083
Human
actin filament based processGO:00300292240.082
Human
system processGO:00030083490.081
transmembrane transportGO:00550853990.080
epithelium developmentGO:00604292270.076
Human
regulation of cell motilityGO:20001452990.074
Human
regulation of locomotionGO:00400123290.073
Human
post embryonic developmentGO:000979120.072
negative regulation of programmed cell deathGO:00430693210.071
Human
locomotory behaviorGO:000762610.070
cell developmentGO:00484683280.069
Human
immune responseGO:00069553070.068
anatomical structure formation involved in morphogenesisGO:00486462840.067
Human
epithelial cell differentiationGO:00308551410.066
Human
defense responseGO:00069523150.066
negative regulation of cell migrationGO:00303361020.063
Human
g protein coupled receptor signaling pathwayGO:00071862070.060
single organism cellular localizationGO:19025803320.059
Human
single organism membrane organizationGO:00448022680.058
Human
hair cycleGO:0042633280.057
Human
epidermis morphogenesisGO:004873030.056
regulation of cellular component movementGO:00512703340.055
Human
muscle structure developmentGO:0061061980.055
Human
membrane organizationGO:00610242920.054
Human
negative regulation of catalytic activityGO:00430863350.053
cytoplasmic transportGO:00164823790.053
Human
cell adhesionGO:00071553250.053
regulation of cellular ketone metabolic processGO:0010565500.052
negative regulation of cellular component movementGO:00512711060.051
Human
negative regulation of apoptotic processGO:00430663160.050
Human
positive regulation of cellular amino acid metabolic processGO:004576430.050
negative regulation of protein metabolic processGO:00512483910.049
vesicle mediated transportGO:00161923710.049
Human
cardiac muscle cell contractionGO:008600340.049
amine metabolic processGO:0009308440.048
metal ion transportGO:00300012720.048
negative regulation of cell motilityGO:20001461040.047
Human
regulation of cellular amino acid metabolic processGO:000652160.047
regulation of transferase activityGO:00513383550.047
regulation of kinase activityGO:00435493140.046
intracellular protein transportGO:00068862700.046
Human
negative regulation of multicellular organismal processGO:00512413170.045
negative regulation of cellular protein metabolic processGO:00322693530.044
organelle assemblyGO:00709251760.044
Human
regulation of protein kinase activityGO:00458592890.043
regulation of cell migrationGO:00303342890.043
Human
regulation of cellular amine metabolic processGO:0033238110.042
positive regulation of protein phosphorylationGO:00019343130.042
response to lipidGO:00339932060.042
Human
copulationGO:000762010.042
response to organic cyclic compoundGO:00140702040.042
Human
response to abiotic stimulusGO:00096283360.041
cellular amine metabolic processGO:0044106410.041
positive regulation of transportGO:00510503360.041
cellular component morphogenesisGO:00329893140.041
Human
regulation of cell differentiationGO:00455953930.040
response to oxygen containing compoundGO:19017003690.040
negative regulation of locomotionGO:00400131180.040
Human
hair follicle morphogenesisGO:003106920.040
actin filament based movementGO:0030048170.039
monovalent inorganic cation transportGO:00156721280.039
muscle contractionGO:0006936730.038
regulation of response to external stimulusGO:00321012220.038
muscle system processGO:0003012810.038
organ morphogenesisGO:00098871470.038
regulation of proteolysisGO:00301622930.037
purine ribonucleoside metabolic processGO:00461284370.037
endomembrane system organizationGO:00102561960.036
Human
positive regulation of cellular amine metabolic processGO:003324070.036
intermediate filament cytoskeleton organizationGO:0045104170.036
Human
secretionGO:00469032540.036
actin cytoskeleton organizationGO:00300362070.036
Human
positive regulation of immune system processGO:00026842830.035
positive regulation of cell proliferationGO:00082843010.034
response to hormoneGO:00097251750.034
Human
mapk cascadeGO:00001652880.034
signal transduction by phosphorylationGO:00230142970.033
cation homeostasisGO:00550801890.033
regulation of secretionGO:00510461940.033
protein processingGO:00164852260.033
negative regulation of hydrolase activityGO:00513461820.033
nucleoside phosphate catabolic processGO:19012924120.032
striated muscle contractionGO:0006941520.032
negative regulation of phosphate metabolic processGO:00459362670.032
protein localization to plasma membraneGO:0072659930.032
Human
keratinocyte differentiationGO:0030216360.032
Human
tissue homeostasisGO:0001894630.032
nucleoside catabolic processGO:00091644080.031
protein maturationGO:00516042330.031
regenerationGO:003109940.031
calcium ion transportGO:00068161470.031
cellular ketone metabolic processGO:0042180800.031
lipid metabolic processGO:00066293810.030
cellular macromolecule catabolic processGO:00442653800.030
intermediate filament organizationGO:0045109100.030
Human
regulation of purine nucleotide metabolic processGO:19005422640.030
positive regulation of transferase activityGO:00513472270.030
actin mediated cell contractionGO:0070252120.030
inorganic cation transmembrane transportGO:00986621940.030
multicellular organismal agingGO:001025930.030
regulation of protein localizationGO:00328802960.030
glycosyl compound catabolic processGO:19016584130.029
regulation of ion transportGO:00432691890.029
cell projection organizationGO:00300302520.029
positive regulation of protein kinase activityGO:00458601900.029
protein catabolic processGO:00301633250.029
neurological system processGO:00508771630.029
purine nucleotide catabolic processGO:00061954050.029
cranial nerve developmentGO:002154540.029
cytokine productionGO:00018162470.029
establishment of protein localization to membraneGO:00901501210.029
Human
skin developmentGO:0043588760.029
Human
biological adhesionGO:00226103310.029
cell activationGO:00017752130.029
cellular amino acid metabolic processGO:00065201160.029
ribonucleoside catabolic processGO:00424544060.029
cell morphogenesisGO:00009022960.029
positive regulation of developmental processGO:00510943140.028
striated muscle cell differentiationGO:0051146430.028
Human
ribonucleoside triphosphate metabolic processGO:00091994120.028
innate immune responseGO:00450871780.028
chemical homeostasisGO:00488783060.028
purine ribonucleotide catabolic processGO:00091544040.028
response to other organismGO:00517072610.028
regulation of cell cycleGO:00517263930.028
determination of adult lifespanGO:000834020.028
protein localization to membraneGO:00726571600.027
Human
regulation of immune responseGO:00507762010.027
cellular component assembly involved in morphogenesisGO:0010927730.027
Human
purine nucleoside triphosphate metabolic processGO:00091444120.027
regulation of hormone levelsGO:00108171250.027
anatomical structure homeostasisGO:00602491000.027
regulation of anatomical structure morphogenesisGO:00226032860.027
inorganic ion transmembrane transportGO:00986602310.027
nucleotide catabolic processGO:00091664080.027
purine ribonucleoside catabolic processGO:00461303980.027
cardiac muscle contractionGO:0060048340.027
enzyme linked receptor protein signaling pathwayGO:00071673030.027
anion transportGO:00068201610.027
cation transmembrane transportGO:00986552380.026
blood circulationGO:00080151130.026
secretion by cellGO:00329402260.026
divalent inorganic cation transportGO:00725111580.026
organophosphate catabolic processGO:00464344300.026
neuromuscular junction developmentGO:000752830.025
female gamete generationGO:000729220.025
epidermal cell differentiationGO:0009913450.025
Human
ribonucleoside triphosphate catabolic processGO:00092033910.025
regulation of nucleotide metabolic processGO:00061402690.025
negative regulation of protein maturationGO:19033181420.025
regulation of transmission of nerve impulseGO:005196920.025
nucleoside triphosphate catabolic processGO:00091433940.025
golgi vesicle transportGO:0048193800.025
Human
segmentationGO:003528240.025
cellular lipid metabolic processGO:00442553030.025
positive regulation of cytosolic calcium ion concentrationGO:0007204820.025
ion homeostasisGO:00508012300.025
immune effector processGO:00022521590.024
regulation of protein maturationGO:19033171500.024
growthGO:00400072020.024
purine ribonucleoside triphosphate catabolic processGO:00092073910.024
negative regulation of phosphorus metabolic processGO:00105632670.024
epidermis developmentGO:0008544590.024
Human
positive regulation of cell differentiationGO:00455972110.024
negative regulation of developmental processGO:00510932470.024
cellular response to endogenous stimulusGO:00714953360.024
plasma membrane organizationGO:00070091150.024
Human
regulation of protein processingGO:00706131500.024
regulation of membrane potentialGO:0042391950.024
oogenesisGO:004847720.024
nucleoside triphosphate metabolic processGO:00091414220.024
organic hydroxy compound metabolic processGO:19016151470.023
regulation of mapk cascadeGO:00434082620.023
positive regulation of acrosome reactionGO:200034440.023
purine containing compound catabolic processGO:00725234110.023
cellular response to dna damage stimulusGO:00069743790.023
positive regulation of hydrolase activityGO:00513453310.023
positive regulation of immune responseGO:00507781590.023
ribonucleotide catabolic processGO:00092614050.023
cell cell signalingGO:00072671550.023
cellular protein catabolic processGO:00442572610.023
ras protein signal transductionGO:0007265730.023
nervous system developmentGO:00073992930.023
covalent chromatin modificationGO:00165692540.023
regulation of establishment of protein localizationGO:00702012420.023
positive regulation of kinase activityGO:00336742040.023
rhythmic behaviorGO:000762220.023
positive regulation of cell motilityGO:20001471770.023
positive regulation of programmed cell deathGO:00430682490.022
regulation of multi organism processGO:00439001570.022
regulation of peptidase activityGO:00525471800.022
cellular response to growth factor stimulusGO:00713631970.022
purine ribonucleoside triphosphate metabolic processGO:00092054110.022
regulation of endopeptidase activityGO:00525481700.022
regulation of thyroid hormone generationGO:200060920.022
response to external biotic stimulusGO:00432072610.022
calcium ion homeostasisGO:00550741220.022
regulation of acrosome reactionGO:006004640.022
cellular divalent inorganic cation homeostasisGO:00725031280.022
purine nucleoside catabolic processGO:00061523980.021
response to biotic stimulusGO:00096072760.021
muscle cell differentiationGO:0042692630.021
Human
negative regulation of protein modification processGO:00314002000.021
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.021
cellular macromolecular complex assemblyGO:00346223240.021
positive regulation of mapk cascadeGO:00434101900.021
regulation of cellular response to stressGO:00801352440.021
apoptotic signaling pathwayGO:00971902680.021
small gtpase mediated signal transductionGO:0007264780.021
organonitrogen compound biosynthetic processGO:19015662000.021
purine nucleoside triphosphate catabolic processGO:00091463920.021
nitrogen compound transportGO:00717051910.021
maintenance of locationGO:00512351120.021
positive regulation of apoptotic processGO:00430652460.021
adult locomotory behaviorGO:000834410.021
regulation of secretion by cellGO:19035301770.021
protein modification by small protein conjugationGO:00324463420.021
positive regulation of cellular component movementGO:00512721810.021
positive regulation of cellular catabolic processGO:00313312840.021
post golgi vesicle mediated transportGO:0006892360.020
Human
cellular calcium ion homeostasisGO:00068741170.020
cellular metal ion homeostasisGO:00068751460.020
chromatin modificationGO:00165682980.020
metal ion homeostasisGO:00550651690.020
single organism cell adhesionGO:00986021790.020
modification dependent macromolecule catabolic processGO:00436322120.020
divalent metal ion transportGO:00708381520.020
regulation of intracellular transportGO:00323861950.020
positive regulation of cellular component organizationGO:00511303760.020
negative regulation of peptidase activityGO:0010466910.020
positive regulation of cell deathGO:00109422630.020
hindbrain developmentGO:003090230.020
negative regulation of protein processingGO:00109551420.020
response to growth factorGO:00708482050.020
divalent inorganic cation homeostasisGO:00725071360.020
positive regulation of cell migrationGO:00303351720.020
positive regulation of secretion by cellGO:19035321080.020
regulation of nucleotide catabolic processGO:00308112050.020
dephosphorylationGO:00163112090.020
multicellular organismal homeostasisGO:0048871670.020
regulation of protein transportGO:00512232130.020
wound healingGO:00420601150.019
activation of immune responseGO:00022531140.019
positive regulation of cytokine productionGO:00018191670.019
positive regulation of locomotionGO:00400171860.019
response to steroid hormoneGO:0048545800.019
Human
protein oligomerizationGO:00512591730.019
regulation of cytokine productionGO:00018172320.019
protein ubiquitinationGO:00165673140.019
organ formationGO:004864530.019
proteolysis involved in cellular protein catabolic processGO:00516032440.019
startle responseGO:000196430.019
regulation of protein serine threonine kinase activityGO:00719001790.019
positive regulation of catabolic processGO:00098963100.019
negative regulation of proteolysisGO:00458611320.019
chromatin organizationGO:00063253510.019
sodium ion transportGO:0006814610.019
positive regulation of nucleotide metabolic processGO:00459812300.019
cellular homeostasisGO:00197251960.019
urate transportGO:001574730.019
generation of neuronsGO:00486991520.019
matingGO:000761810.019
nucleoside monophosphate metabolic processGO:00091231910.019
symbiosis encompassing mutualism through parasitismGO:00444031560.019
response to woundingGO:00096111680.019
atp metabolic processGO:00460341760.019
cellular cation homeostasisGO:00300031630.019
circulatory system developmentGO:00723592620.019
blastoderm segmentationGO:000735020.018
circulatory system processGO:00030131130.018
memoryGO:000761330.018
leukocyte activationGO:00453211640.018
single organismal cell cell adhesionGO:00163371480.018
neurogenesisGO:00220081690.018
negative regulation of cellular component organizationGO:00511292350.018
regulation of cellular component biogenesisGO:00440872810.018
response to radiationGO:00093141510.018
carbohydrate metabolic processGO:00059752070.018
metencephalon developmentGO:002203720.018
alcohol metabolic processGO:00060661140.018
cellular ion homeostasisGO:00068731680.018
hormone metabolic processGO:0042445610.018
positive regulation of secretionGO:00510471160.017
cardiovascular system developmentGO:00723582620.017
single organism carbohydrate metabolic processGO:00447231930.017
protein localization to organelleGO:00333652800.017
response to hypoxiaGO:0001666960.017
reactive oxygen species metabolic processGO:0072593750.017
detection of stimulusGO:0051606850.017
actomyosin structure organizationGO:0031032590.017
Human
salivary gland morphogenesisGO:000743540.017
regulation of apoptotic signaling pathwayGO:20012331750.017
circadian behaviorGO:004851220.017
purine ribonucleoside monophosphate metabolic processGO:00091671860.017
positive regulation of intestinal epithelial structure maintenanceGO:006073110.017
cellular response to oxygen containing compoundGO:19017012760.017
positive regulation of purine nucleotide metabolic processGO:19005442270.017
ribonucleoside monophosphate metabolic processGO:00091611870.017
modification dependent protein catabolic processGO:00199412090.017
molting cycleGO:0042303280.017
Human
ubiquitin dependent protein catabolic processGO:00065112060.017
regulation of neural precursor cell proliferationGO:200017740.016
wnt signaling pathwayGO:00160551560.016
carbohydrate derivative biosynthetic processGO:19011372070.016
synaptic transmission involved in micturitionGO:006008420.016
positive regulation of hormone biosynthetic processGO:004688640.016
sequestering of metal ionGO:0051238240.016
regulation of cell activationGO:00508651250.016
photoreceptor cell differentiationGO:004653020.016
purine nucleoside monophosphate metabolic processGO:00091261860.016
nerve developmentGO:002167540.016
regulation of nucleoside metabolic processGO:00091182090.016
peripheral nervous system developmentGO:000742220.016
sequestering of calcium ionGO:0051208170.016
tissue regenerationGO:004224630.016
epithelial cell proliferationGO:00506731280.016
response to estrogenGO:0043627470.016
Human
negative regulation of acetylcholine gated cation channel activityGO:190304910.016
regulation of homeostatic processGO:00328441210.016
mitotic cell cycleGO:00002783260.016
muscle cell developmentGO:0055001290.016
Human
negative regulation of cell differentiationGO:00455961710.016
regulation of cell cycle processGO:00105642660.016
compound eye developmentGO:004874910.016
purine nucleoside monophosphate catabolic processGO:00091281580.016
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.016
positive regulation of protein transportGO:00512221350.015
regulation of protein catabolic processGO:00421761550.015
regulation of system processGO:00440571010.015
regulation of sequence specific dna binding transcription factor activityGO:00510902110.015
potassium ion transmembrane transportGO:0071805600.015
regulation of ion transmembrane transportGO:00347651320.015
regulation of leukocyte activationGO:00026941150.015
response to oxygen levelsGO:00704821000.015
rho protein signal transductionGO:0007266260.015
negative regulation of cellular amine metabolic processGO:003323930.015
regulation of purine nucleotide catabolic processGO:00331212050.015
sensory perceptionGO:00076001030.015
negative regulation of intracellular signal transductionGO:19025321830.015
response to bacteriumGO:00096171440.015
micturitionGO:006007330.015
dna repairGO:00062811980.015
nucleoside monophosphate catabolic processGO:00091251590.015
limbic system developmentGO:002176130.015
purine ribonucleoside monophosphate catabolic processGO:00091691580.015
regulation of defense responseGO:00313471540.015
regulation of cell developmentGO:00602841610.015
regulation of reactive oxygen species metabolic processGO:2000377410.015
histone modificationGO:00165702510.015
regulation of body fluid levelsGO:0050878990.015
oocyte developmentGO:004859910.015
cellular potassium ion transportGO:0071804600.015
proteasomal protein catabolic processGO:00104981760.015
negative regulation of cell proliferationGO:00082852280.014
multicellular organismal signalingGO:0035637340.014
regulation of transmembrane transportGO:00347621390.014
monocarboxylic acid metabolic processGO:00327871850.014
cell part morphogenesisGO:00329901370.014
humoral immune responseGO:0006959490.014
anterior posterior axis specificationGO:000994820.014
phospholipid metabolic processGO:0006644990.014
cellular response to organonitrogen compoundGO:00714171240.014
neuroblast proliferationGO:000740540.014
neuron differentiationGO:00301821380.014
atp catabolic processGO:00062001570.014
potassium ion transportGO:0006813620.014
oxidation reduction processGO:00551143960.014
positive regulation of nucleoside metabolic processGO:00459791860.014
negative regulation of endopeptidase activityGO:0010951840.014
ribonucleoside monophosphate catabolic processGO:00091581580.014
cell divisionGO:00513011680.014
motor neuron axon guidanceGO:000804520.014
cell growthGO:00160491600.014
response to decreased oxygen levelsGO:0036293960.014
cellular protein complex assemblyGO:00436231880.014
spermatid differentiationGO:004851540.014
regulation of i kappab kinase nf kappab signalingGO:00431221620.014
small molecule biosynthetic processGO:00442831570.014
protein secretionGO:0009306980.014
cytosolic calcium ion homeostasisGO:0051480890.014
negative regulation of cellular amino acid metabolic processGO:004576320.014
negative regulation of response to external stimulusGO:0032102830.014
organophosphate biosynthetic processGO:00904071630.014
cellular chemical homeostasisGO:00550821800.014
multi organism cellular processGO:00447641560.014
mitotic cell cycle processGO:19030472860.014
regulation of vesicle mediated transportGO:00606271300.014
cellular response to histamineGO:007142030.014
organic anion transportGO:00157111030.014
microtubule based processGO:00070172100.014
protein homooligomerizationGO:00512601000.014
establishment of protein localization to plasma membraneGO:0090002680.014
Human
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.014
i kappab kinase nf kappab signalingGO:00072491660.014
response to axon injuryGO:004867810.014
negative regulation of phosphorylationGO:00423261740.013
negative regulation of transferase activityGO:00513481240.013
cellular response to lipidGO:00713961270.013
leukocyte migrationGO:00509001070.013
associative learningGO:000830610.013
cellular response to abiotic stimulusGO:00712141170.013
regulation of epithelial cell proliferationGO:00506781130.013
response to fungusGO:000962040.013
positive regulation of nucleotide catabolic processGO:00308131850.013
blastocyst developmentGO:000182430.013
tripartite regional subdivisionGO:000735120.013
neuron projection regenerationGO:003110210.013
response to drugGO:0042493810.013
morphogenesis of embryonic epitheliumGO:001633140.013
immune system developmentGO:00025201950.013
post embryonic organ developmentGO:004856910.013
response to inorganic substanceGO:00100351270.013
regulation of growthGO:00400081650.013
regulation of cell growthGO:00015581350.013
regulation of cell adhesionGO:00301551660.013
protein targetingGO:00066051870.013
action potentialGO:0001508340.013
blood vessel developmentGO:00015681720.013
vasodilationGO:004231140.013
regulation of blood circulationGO:1903522590.013
taxisGO:00423301570.013
guanosine containing compound metabolic processGO:19010682440.013
syncytium formation by plasma membrane fusionGO:000076820.013
regulation of acetylcholine gated cation channel activityGO:190304810.013
angiogenesisGO:00015251470.013
negative regulation of protein phosphorylationGO:00019331400.013
interspecies interaction between organismsGO:00444191560.013
anion transmembrane transportGO:0098656760.013
regulation of cysteine type endopeptidase activityGO:20001161270.013
positive regulation of cell cycleGO:00457871400.013
regulation of cytoplasmic transportGO:19036491490.013
tissue migrationGO:00901301190.012
sleepGO:003043120.012
cell cycle phase transitionGO:00447701730.012
myeloid cell differentiationGO:00300991170.012
neuron developmentGO:00486661130.012
response to light stimulusGO:0009416870.012
activation of protein kinase activityGO:0032147900.012
anterior posterior axis specification embryoGO:000859520.012
sodium ion transmembrane transportGO:0035725590.012
guanosine containing compound catabolic processGO:19010692390.012
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.012
cellular response to external stimulusGO:00714961110.012
postsynaptic membrane organizationGO:000194120.012
cannabinoid signaling pathwayGO:003817120.012
oocyte differentiationGO:000999420.012
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.012
gtp metabolic processGO:00460392390.012
regulation of anatomical structure sizeGO:00900661010.012
response to extracellular stimulusGO:0009991850.012
regulation of wnt signaling pathwayGO:00301111230.012
behaviorGO:00076101120.012
cell substrate adhesionGO:00315891320.012
response to nitrogen compoundGO:19016981840.012
regulation of dna metabolic processGO:00510521530.012
neuron projection developmentGO:00311751060.012
positive regulation of reactive oxygen species biosynthetic processGO:190342820.012
inner ear morphogenesisGO:004247240.012
negative regulation of synaptic transmissionGO:005080520.012
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.012
agingGO:0007568660.012
Human
organic acid transportGO:0015849650.012
regulation of reactive oxygen species biosynthetic processGO:190342630.012
rna processingGO:00063962550.012
epithelial cell migrationGO:00106311190.012
retina homeostasisGO:0001895420.012
chemotaxisGO:00069351570.012

KRT37 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
sensory system diseaseDOID:00501552030.039
nervous system diseaseDOID:8634310.039
eye and adnexa diseaseDOID:14921500.029
eye diseaseDOID:56141490.029
musculoskeletal system diseaseDOID:172230.025
retinal diseaseDOID:56791180.024
central nervous system diseaseDOID:3311860.020
disease of cellular proliferationDOID:145661740.019
cancerDOID:1621670.019
organ system cancerDOID:00506861640.018
kidney diseaseDOID:557360.017
renal tubular transport diseaseDOID:447110.017
urinary system diseaseDOID:18400.017
disease of metabolismDOID:00146672950.017
night blindnessDOID:8499100.016
inherited metabolic disorderDOID:6552420.015
immune system diseaseDOID:29141550.012
bone diseaseDOID:0080001880.012
connective tissue diseaseDOID:651090.012
neurodegenerative diseaseDOID:12891020.012