Homo sapiens

89 known processes

SIX3

SIX homeobox 3

(Aliases: HPE2)

SIX3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
neuron fate commitmentGO:004866320.807
forebrain generation of neuronsGO:002187230.422
spinal cord developmentGO:002151040.347
negative regulation of multicellular organismal processGO:00512413170.320
hindbrain developmentGO:003090230.306
organ morphogenesisGO:00098871470.305
Fly
regulation of cell differentiationGO:00455953930.291
nervous system developmentGO:00073992930.279
system processGO:00030083490.259
neuron differentiationGO:00301821380.255
Fly
inner ear morphogenesisGO:004247240.245
cell morphogenesisGO:00009022960.236
Fly
brain developmentGO:0007420970.234
cell developmentGO:00484683280.229
Fly
circulatory system developmentGO:00723592620.227
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.227
forelimb morphogenesisGO:003513640.219
cell fate determinationGO:000170930.215
organ formationGO:004864530.206
anatomical structure formation involved in morphogenesisGO:00486462840.199
positive regulation of cell proliferationGO:00082843010.195
cell cell signalingGO:00072671550.194
pituitary gland developmentGO:002198320.189
regulation of locomotionGO:00400123290.187
cardiovascular system developmentGO:00723582620.181
regulation of cellular component movementGO:00512703340.180
response to oxygen containing compoundGO:19017003690.173
cellular component morphogenesisGO:00329893140.170
Fly
generation of neuronsGO:00486991520.170
Fly
central nervous system developmentGO:00074171230.169
cell projection organizationGO:00300302520.169
Fly
regulation of cell migrationGO:00303342890.166
regulation of cellular amino acid metabolic processGO:000652160.162
regulation of cellular amine metabolic processGO:0033238110.157
positive regulation of cell differentiationGO:00455972110.154
positive regulation of developmental processGO:00510943140.153
forebrain neuron differentiationGO:002187930.152
cellular amino acid metabolic processGO:00065201160.151
cell morphogenesis involved in differentiationGO:00009041440.150
Fly
positive regulation of cellular amino acid metabolic processGO:004576430.149
cranial nerve developmentGO:002154540.145
amine metabolic processGO:0009308440.144
embryonic morphogenesisGO:0048598850.142
positive regulation of cellular amine metabolic processGO:003324070.139
regulation of neuron differentiationGO:0045664700.137
negative regulation of developmental processGO:00510932470.137
epithelium developmentGO:00604292270.137
neuron projection developmentGO:00311751060.135
Fly
secretion by cellGO:00329402260.135
regulation of cell motilityGO:20001452990.135
forebrain dorsal ventral pattern formationGO:002179810.135
regulation of cellular ketone metabolic processGO:0010565500.130
tube morphogenesisGO:0035239950.129
tube developmentGO:00352951250.126
cardiac cell fate determinationGO:006091330.125
regulation of hormone levelsGO:00108171250.122
cellular amine metabolic processGO:0044106410.122
post embryonic developmentGO:000979120.121
Worm
secretionGO:00469032540.120
neuron developmentGO:00486661130.116
Fly
negative regulation of cell deathGO:00605483450.116
regulation of secretion by cellGO:19035301770.115
nerve developmentGO:002167540.113
specification of organ identityGO:001009230.113
limbic system developmentGO:002176130.112
glial cell migrationGO:000834740.111
negative regulation of cell differentiationGO:00455961710.110
cerebral cortex gabaergic interneuron differentiationGO:002189210.110
behaviorGO:00076101120.110
tissue morphogenesisGO:0048729960.107
neurogenesisGO:00220081690.107
Fly
taxisGO:00423301570.106
skeletal system developmentGO:0001501790.105
cellular response to endogenous stimulusGO:00714953360.104
head developmentGO:00603221080.103
regulation of secretionGO:00510461940.103
segmentationGO:003528240.100
forebrain regionalizationGO:002187130.098
negative regulation of apoptotic processGO:00430663160.098
regulation of cell developmentGO:00602841610.098
chemotaxisGO:00069351570.097
locomotory behaviorGO:000762610.093
stem cell differentiationGO:0048863930.086
metencephalon developmentGO:002203720.085
renal system developmentGO:0072001630.085
Human
negative regulation of cell proliferationGO:00082852280.084
neurological system processGO:00508771630.084
enzyme linked receptor protein signaling pathwayGO:00071673030.084
morphogenesis of embryonic epitheliumGO:001633140.083
regulation of anatomical structure morphogenesisGO:00226032860.082
response to growth factorGO:00708482050.082
positive regulation of tooth mineralizationGO:007017220.082
cellular ketone metabolic processGO:0042180800.082
embryonic camera type eye developmentGO:003107620.081
cell differentiation in spinal cordGO:002151510.080
neuron projection morphogenesisGO:0048812500.080
Fly
somatic stem cell maintenanceGO:003501940.078
regulation of neurogenesisGO:0050767820.077
growthGO:00400072020.077
positive regulation of transportGO:00510503360.077
adult locomotory behaviorGO:000834410.076
response to abiotic stimulusGO:00096283360.075
cellular response to growth factor stimulusGO:00713631970.074
embryonic forelimb morphogenesisGO:003511540.074
positive regulation of phosphorylationGO:00423273940.073
vasculature developmentGO:00019441810.073
negative regulation of programmed cell deathGO:00430693210.072
positive regulation of neural precursor cell proliferationGO:200017920.071
cardiac right ventricle morphogenesisGO:000321530.071
hormone secretionGO:0046879650.071
embryonic organ morphogenesisGO:0048562240.069
cell projection morphogenesisGO:00488581290.069
Fly
regulation of cell cycleGO:00517263930.067
pancreatic a cell differentiationGO:000331010.066
positive regulation of cell deathGO:00109422630.065
cellular response to oxygen containing compoundGO:19017012760.064
negative regulation of protein metabolic processGO:00512483910.063
limb bud formationGO:006017410.062
neural tube patterningGO:002153220.061
kidney developmentGO:0001822530.060
Human
endocrine system developmentGO:0035270260.060
regulation of hormone secretionGO:0046883570.060
negative regulation of cellular protein metabolic processGO:00322693530.060
embryonic organ developmentGO:0048568360.060
forebrain developmentGO:0030900260.059
sensory organ morphogenesisGO:0090596210.059
Fly
lipid metabolic processGO:00066293810.058
stem cell developmentGO:0048864690.057
peripheral nervous system developmentGO:000742220.057
mitotic cell cycleGO:00002783260.057
regulation of stem cell differentiationGO:2000736560.055
regulation of nervous system developmentGO:0051960880.055
epithelial cell differentiationGO:00308551410.054
cell part morphogenesisGO:00329901370.053
Fly
neuroblast proliferationGO:000740540.053
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.053
cerebellum developmentGO:002154920.053
mitotic cell cycle processGO:19030472860.052
blood vessel morphogenesisGO:00485141620.052
chromatin organizationGO:00063253510.052
sensory organ developmentGO:0007423520.051
globus pallidus developmentGO:002175910.051
positive regulation of cell motilityGO:20001471770.051
positive regulation of cell fate specificationGO:004266020.051
outflow tract septum morphogenesisGO:000314840.050
cellular response to dna damage stimulusGO:00069743790.050
positive regulation of apoptotic processGO:00430652460.050
heart formationGO:006091420.050
ameboidal type cell migrationGO:00016671350.050
positive regulation of cellular component movementGO:00512721810.049
regulation of response to external stimulusGO:00321012220.049
regulation of kinase activityGO:00435493140.049
regionalizationGO:0003002290.048
telencephalon developmentGO:0021537170.048
positive regulation of cellular component organizationGO:00511303760.048
cytokine productionGO:00018162470.048
epithelial cell proliferationGO:00506731280.048
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiationGO:000325730.048
regulation of neural precursor cell proliferationGO:200017740.047
response to lipidGO:00339932060.047
pallium developmentGO:0021543100.047
neural crest cell developmentGO:001403230.047
positive regulation of locomotionGO:00400171860.046
cell proliferation in forebrainGO:002184610.046
negative regulation of cell developmentGO:0010721480.046
embryonic epithelial tube formationGO:000183840.046
positive regulation of synaptic transmissionGO:005080640.046
cellular response to hormone stimulusGO:00328701250.045
regulation of growthGO:00400081650.045
small gtpase mediated signal transductionGO:0007264780.045
immune responseGO:00069553070.045
response to woundingGO:00096111680.045
hormone transportGO:0009914680.044
blood vessel developmentGO:00015681720.044
regulation of protein localizationGO:00328802960.044
embryonic camera type eye morphogenesisGO:004859620.043
cell morphogenesis involved in neuron differentiationGO:0048667440.043
Fly
regulation of cytokine productionGO:00018172320.043
regulation of epithelial cell proliferationGO:00506781130.043
regenerationGO:003109940.043
cartilage condensationGO:000150210.042
ras protein signal transductionGO:0007265730.042
urogenital system developmentGO:0001655650.042
Human
chemical homeostasisGO:00488783060.042
multicellular organismal agingGO:001025930.041
sex determinationGO:000753030.041
memoryGO:000761330.041
signal releaseGO:0023061700.041
regulation of male gonad developmentGO:200001840.040
embryo developmentGO:00097901230.040
Worm
rostrocaudal neural tube patterningGO:002190310.040
motor neuron axon guidanceGO:000804520.039
embryonic eye morphogenesisGO:004804820.039
female gamete generationGO:000729220.039
sensory perceptionGO:00076001030.039
negative regulation of neurogenesisGO:0050768260.039
defense responseGO:00069523150.039
cellular chemical homeostasisGO:00550821800.039
cellular homeostasisGO:00197251960.038
regulation of cell cycle processGO:00105642660.038
positive regulation of programmed cell deathGO:00430682490.038
response to hormoneGO:00097251750.038
cytoplasmic transportGO:00164823790.038
nitrogen compound transportGO:00717051910.038
pattern specification processGO:0007389430.038
negative regulation of phosphorus metabolic processGO:00105632670.038
blastoderm segmentationGO:000735020.037
compound eye developmentGO:004874910.037
Fly
digestive system developmentGO:0055123750.037
regulation of synaptic plasticityGO:004816730.037
anterior posterior axis specificationGO:000994820.036
response to nitrogen compoundGO:19016981840.036
negative regulation of cellular component organizationGO:00511292350.036
cellular response to organonitrogen compoundGO:00714171240.036
metal ion transportGO:00300012720.036
heart morphogenesisGO:0003007480.036
positive regulation of secretion by cellGO:19035321080.035
hippocampus developmentGO:002176610.035
response to external biotic stimulusGO:00432072610.035
positive regulation of odontogenesisGO:004248230.035
synaptic transmissionGO:0007268610.035
response to biotic stimulusGO:00096072760.034
cellular response to nitrogen compoundGO:19016991440.034
negative regulation of protein modification processGO:00314002000.034
dermatome developmentGO:006105430.034
epithelial tube branching involved in lung morphogenesisGO:006044140.034
ossificationGO:00015031210.034
mesenchymal cell developmentGO:0014031500.034
endothelial cell migrationGO:0043542860.034
ion homeostasisGO:00508012300.034
tissue migrationGO:00901301190.034
digestive tract developmentGO:0048565750.034
positive regulation of protein phosphorylationGO:00019343130.033
pulmonary vein morphogenesisGO:006057710.033
endodermal cell fate commitmentGO:000171140.033
inorganic ion transmembrane transportGO:00986602310.033
regulation of establishment of protein localizationGO:00702012420.033
response to organic cyclic compoundGO:00140702040.033
cell divisionGO:00513011680.033
determination of adult lifespanGO:000834020.033
morphogenesis of an epitheliumGO:0002009600.033
muscle structure developmentGO:0061061980.033
cell fate commitmentGO:0045165270.032
response to organonitrogen compoundGO:00102431560.032
epithelial cell migrationGO:00106311190.032
skin developmentGO:0043588760.032
positive regulation of secretionGO:00510471160.032
positive regulation of hydrolase activityGO:00513453310.032
positive regulation of epithelial cell proliferation involved in wound healingGO:006005430.032
astrocyte differentiationGO:004870840.032
regulation of cell growthGO:00015581350.031
epithelium migrationGO:00901321190.031
regulation of cell morphogenesis involved in differentiationGO:0010769830.031
embryonic camera type eye formationGO:006090020.031
canonical wnt signaling pathway involved in mesenchymal stem cell differentiationGO:004433820.031
gabaergic neuron differentiationGO:009715410.031
protein localization to organelleGO:00333652800.031
Human
chromatin modificationGO:00165682980.031
cell type specific apoptotic processGO:00972851250.030
actin filament based processGO:00300292240.030
cellular macromolecular complex assemblyGO:00346223240.030
positive regulation of cell migrationGO:00303351720.030
cell adhesionGO:00071553250.030
positive regulation of epithelial cell proliferationGO:0050679650.030
axonogenesisGO:0007409310.030
cation transportGO:00068123310.030
immune effector processGO:00022521590.029
cell growthGO:00160491600.029
neuromuscular junction developmentGO:000752830.029
nucleoside catabolic processGO:00091644080.029
negative regulation of gliogenesisGO:001401430.029
cell fate commitment involved in pattern specificationGO:006058110.029
cerebral cortex cell migrationGO:002179530.029
ribonucleoside catabolic processGO:00424544060.029
ventral spinal cord developmentGO:002151710.029
biological adhesionGO:00226103310.029
right ventricular cardiac muscle tissue morphogenesisGO:000322120.029
peptide transportGO:0015833740.029
amide transportGO:0042886760.028
negative regulation of cell cycleGO:00457861930.028
positive regulation of hormone biosynthetic processGO:004688640.028
purine ribonucleoside metabolic processGO:00461284370.028
regulation of protein kinase activityGO:00458592890.028
apoptotic signaling pathwayGO:00971902680.028
mesenchyme developmentGO:0060485590.028
ventral spinal cord interneuron differentiationGO:002151410.028
regulation of cardioblast differentiationGO:005189040.028
mesonephric duct developmentGO:007217730.028
regulation of protein transportGO:00512232130.028
oogenesisGO:004847720.028
regulation of wnt signaling pathwayGO:00301111230.028
positive regulation of aldosterone metabolic processGO:003234620.028
cation transmembrane transportGO:00986552380.028
regulation of proteolysisGO:00301622930.027
cellular lipid metabolic processGO:00442553030.027
negative regulation of catalytic activityGO:00430863350.027
salivary gland morphogenesisGO:000743540.027
positive regulation of cardioblast differentiationGO:005189120.027
negative regulation of transportGO:00510511760.027
inner ear developmentGO:004883980.027
mesenchymal cell differentiationGO:0048762520.027
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.027
nucleoside phosphate catabolic processGO:19012924120.027
endodermal cell fate specificationGO:000171440.027
positive regulation of nervous system developmentGO:0051962540.027
canonical wnt signaling pathway involved in osteoblast differentiationGO:004433920.026
regulation of ion transportGO:00432691890.026
response to other organismGO:00517072610.026
regulation of mitotic cell cycleGO:00073461890.026
regulation of cellular response to stressGO:00801352440.026
follicle stimulating hormone secretionGO:004688430.026
osteoblast differentiationGO:0001649920.026
paramesonephric duct developmentGO:006120520.026
regulation of cellular component biogenesisGO:00440872810.026
regulation of system processGO:00440571010.026
positive regulation of cell cycleGO:00457871400.026
central nervous system neuron differentiationGO:002195390.026
ribonucleoside triphosphate catabolic processGO:00092033910.026
positive regulation of cytokine productionGO:00018191670.026
cellular response to acid chemicalGO:0071229440.026
purine nucleoside catabolic processGO:00061523980.026
gland developmentGO:0048732480.026
transmembrane transportGO:00550853990.025
positive regulation of cell developmentGO:0010720920.025
angiogenesisGO:00015251470.025
inorganic cation transmembrane transportGO:00986621940.025
cellular macromolecule catabolic processGO:00442653800.025
eye photoreceptor cell differentiationGO:000175420.025
Fly
brain morphogenesisGO:004885410.025
immune system developmentGO:00025201950.025
regulation of cell projection organizationGO:00313441070.025
negative regulation of cell migrationGO:00303361020.025
reproductive processGO:00224141060.025
striated muscle tissue developmentGO:0014706590.025
hematopoietic or lymphoid organ developmentGO:00485341860.025
oxidation reduction processGO:00551143960.025
regulation of transferase activityGO:00513383550.025
somitogenesisGO:000175620.025
single organism cellular localizationGO:19025803320.025
muscle system processGO:0003012810.025
posttranscriptional regulation of gene expressionGO:00106082130.025
wnt signaling pathwayGO:00160551560.024
regulation of cell morphogenesisGO:00226041530.024
negative regulation of neuron differentiationGO:0045665210.024
peptide secretionGO:0002790510.024
epithelial tube morphogenesisGO:0060562380.024
negative regulation of growthGO:0045926970.024
regulation of atrial cardiac muscle cell membrane repolarizationGO:006037240.024
protein ubiquitinationGO:00165673140.024
positive regulation of aldosterone biosynthetic processGO:003234920.024
nucleoside triphosphate metabolic processGO:00091414220.024
glycosyl compound catabolic processGO:19016584130.024
forebrain neuron developmentGO:002188420.024
negative regulation of phosphate metabolic processGO:00459362670.024
protein maturationGO:00516042330.023
cell activationGO:00017752130.023
response to radiationGO:00093141510.023
chordate embryonic developmentGO:0043009340.023
mapk cascadeGO:00001652880.023
eye developmentGO:0001654420.023
vesicle mediated transportGO:00161923710.023
response to axon injuryGO:004867810.023
regulation of peptide hormone secretionGO:0090276410.023
cd8 positive alpha beta t cell differentiation involved in immune responseGO:000230210.023
regulation of odontogenesisGO:004248140.023
purine ribonucleoside triphosphate catabolic processGO:00092073910.023
positive regulation of purine nucleotide metabolic processGO:19005442270.023
ribonucleoside triphosphate metabolic processGO:00091994120.023
microtubule cytoskeleton organizationGO:00002261760.023
heart developmentGO:0007507950.023
regulation of bindingGO:00510981110.023
regulation of intracellular transportGO:00323861950.023
response to acid chemicalGO:0001101660.023
photoreceptor cell differentiationGO:004653020.023
Fly
formation of primary germ layerGO:0001704420.022
nucleotide catabolic processGO:00091664080.022
multicellular organismal response to stressGO:003355510.022
purine ribonucleoside triphosphate metabolic processGO:00092054110.022
protein catabolic processGO:00301633250.022
negative regulation of locomotionGO:00400131180.022
canonical wnt signaling pathway involved in cardiac muscle cell fate commitmentGO:006131730.022
muscle tissue developmentGO:0060537620.022
detection of stimulusGO:0051606850.022
positive regulation of neurogenesisGO:0050769490.022
peptide hormone secretionGO:0030072500.022
cellular response to lipidGO:00713961270.022
protein localization to nucleusGO:00345041360.022
Human
hair follicle morphogenesisGO:003106920.022
canonical wnt signaling pathwayGO:00600701160.022
purine containing compound catabolic processGO:00725234110.022
regulation of purine nucleotide metabolic processGO:19005422640.022
ribonucleotide catabolic processGO:00092614050.022
ion transmembrane transportGO:00342203380.022
organonitrogen compound biosynthetic processGO:19015662000.022
luteinizing hormone secretionGO:003227510.022
optic nerve developmentGO:002155420.022
regulation of neuroblast proliferationGO:190269230.022
regulation of neuron projection developmentGO:0010975570.022
regulation of peptidase activityGO:00525471800.022
visual behaviorGO:000763220.022
circadian behaviorGO:004851220.022
cellular response to organic cyclic compoundGO:00714071270.022
nucleoside triphosphate catabolic processGO:00091433940.022
axon developmentGO:0061564340.022
carbohydrate derivative biosynthetic processGO:19011372070.022
positive regulation of mapk cascadeGO:00434101900.022
regulation of nucleotide metabolic processGO:00061402690.022
neural tube formationGO:000184130.022
multicellular organismal signalingGO:0035637340.021
protein modification by small protein conjugationGO:00324463420.021
spinal cord dorsal ventral patterningGO:002151320.021
purine nucleoside triphosphate metabolic processGO:00091444120.021
mesenchymal to epithelial transition involved in metanephros morphogenesisGO:000333740.021
g protein coupled receptor signaling pathwayGO:00071862070.021
monovalent inorganic cation transportGO:00156721280.021
positive regulation of catabolic processGO:00098963100.021
adenylate cyclase inhibiting adrenergic receptor signaling pathwayGO:007188110.021
guanosine containing compound metabolic processGO:19010682440.021
neurotransmitter secretionGO:000726940.021
muscle organ developmentGO:0007517560.021
microtubule based processGO:00070172100.021
regulation of cardiac muscle cell proliferationGO:006004340.021
regulation of epithelial cell migrationGO:0010632930.021
retinal ganglion cell axon guidanceGO:003129020.021
positive regulation of purine nucleotide catabolic processGO:00331231850.021
regulation of immune responseGO:00507762010.021
purine ribonucleoside catabolic processGO:00461303980.021
sensory perception of soundGO:0007605370.021
cellular response to prostaglandin stimulusGO:007137940.020
regulation of canonical wnt signaling pathwayGO:0060828880.020
negative regulation of cell growthGO:0030308830.020
regulation of branching involved in ureteric bud morphogenesisGO:009018930.020
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.020
purine nucleoside triphosphate catabolic processGO:00091463920.020
cellular ion homeostasisGO:00068731680.020
gtp metabolic processGO:00460392390.020
associative learningGO:000830610.020
regulation of dna metabolic processGO:00510521530.020
negative regulation of phosphorylationGO:00423261740.020
ear developmentGO:0043583140.020
histone modificationGO:00165702510.020
reactive oxygen species metabolic processGO:0072593750.020
covalent chromatin modificationGO:00165692540.020
cell cycle phase transitionGO:00447701730.020
negative regulation of kidney developmentGO:009018520.020
positive regulation of neuroblast proliferationGO:000205220.020
rhythmic behaviorGO:000762220.020
cardiac muscle cell contractionGO:008600340.020
positive regulation of nucleoside metabolic processGO:00459791860.019
intracellular protein transportGO:00068862700.019
regulation of heart growthGO:006042040.019
ear morphogenesisGO:004247170.019
oxidative stress induced premature senescenceGO:009040330.019
positive regulation of cellular catabolic processGO:00313312840.019
epidermis developmentGO:0008544590.019
sensory perception of light stimulusGO:0050953350.019
muscle contractionGO:0006936730.019
positive regulation of immune system processGO:00026842830.019
neuron projection regenerationGO:003110210.019
neural crest cell migrationGO:000175520.019
innate immune responseGO:00450871780.019
drinking behaviorGO:004275610.019
protein processingGO:00164852260.019
cytosolic calcium ion homeostasisGO:0051480890.019
neuroendocrine cell differentiationGO:006110120.019
regulation of peptide transportGO:0090087620.019
negative regulation of synaptic transmissionGO:005080520.019
lens development in camera type eyeGO:000208820.019
nucleocytoplasmic transportGO:00069131760.019
regulation of cell adhesionGO:00301551660.019
anterior posterior axis specification embryoGO:000859520.019
monocarboxylic acid metabolic processGO:00327871850.019
nuclear transportGO:00511691790.019
regulation of immune effector processGO:0002697910.018
negative regulation of protein processingGO:00109551420.018
regulation of mapk cascadeGO:00434082620.018
post embryonic organ developmentGO:004856910.018
embryonic viscerocranium morphogenesisGO:004870310.018
matingGO:000761810.018
thymus developmentGO:004853830.018
purine nucleotide catabolic processGO:00061954050.018

SIX3 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:8634310.065
Human
sensory system diseaseDOID:00501552030.065
Human
disease of metabolismDOID:00146672950.049
disease of cellular proliferationDOID:145661740.039
cancerDOID:1621670.039
musculoskeletal system diseaseDOID:172230.036
eye and adnexa diseaseDOID:14921500.033
eye diseaseDOID:56141490.033
organ system cancerDOID:00506861640.031
central nervous system diseaseDOID:3311860.025
connective tissue diseaseDOID:651090.025
bone diseaseDOID:0080001880.025