Homo sapiens

14 known processes

RHOF

ras homolog gene family, member F (in filopodia)

(Aliases: RIF,FLJ20247,ARHF)

RHOF biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amine metabolic processGO:0044106410.067
post embryonic developmentGO:000979120.065
ribonucleoside triphosphate catabolic processGO:00092033910.062
cellular amino acid metabolic processGO:00065201160.062
purine ribonucleoside metabolic processGO:00461284370.061
regulation of cellular ketone metabolic processGO:0010565500.060
amine metabolic processGO:0009308440.059
purine nucleoside triphosphate metabolic processGO:00091444120.059
regulation of cellular amino acid metabolic processGO:000652160.056
ras protein signal transductionGO:0007265730.056
glycosyl compound catabolic processGO:19016584130.055
cellular ketone metabolic processGO:0042180800.055
purine ribonucleoside catabolic processGO:00461303980.055
regulation of cellular amine metabolic processGO:0033238110.054
purine nucleotide catabolic processGO:00061954050.054
nucleoside triphosphate metabolic processGO:00091414220.054
organophosphate catabolic processGO:00464344300.053
small gtpase mediated signal transductionGO:0007264780.053
purine nucleoside catabolic processGO:00061523980.053
positive regulation of cellular amine metabolic processGO:003324070.052
purine ribonucleotide catabolic processGO:00091544040.052
ribonucleoside catabolic processGO:00424544060.051
ribonucleoside triphosphate metabolic processGO:00091994120.051
nucleoside triphosphate catabolic processGO:00091433940.051
nucleoside catabolic processGO:00091644080.049
nucleotide catabolic processGO:00091664080.048
ribonucleotide catabolic processGO:00092614050.048
defense responseGO:00069523150.047
nucleoside phosphate catabolic processGO:19012924120.047
purine ribonucleoside triphosphate metabolic processGO:00092054110.047
purine nucleoside triphosphate catabolic processGO:00091463920.046
positive regulation of cellular amino acid metabolic processGO:004576430.045
immune responseGO:00069553070.044
purine ribonucleoside triphosphate catabolic processGO:00092073910.043
positive regulation of immune system processGO:00026842830.042
positive regulation of catabolic processGO:00098963100.041
positive regulation of cellular catabolic processGO:00313312840.040
purine containing compound catabolic processGO:00725234110.040
multicellular organismal agingGO:001025930.039
regulation of purine nucleotide metabolic processGO:19005422640.038
guanosine containing compound catabolic processGO:19010692390.038
negative regulation of catalytic activityGO:00430863350.038
determination of adult lifespanGO:000834020.037
gtp metabolic processGO:00460392390.037
guanosine containing compound metabolic processGO:19010682440.036
positive regulation of hydrolase activityGO:00513453310.036
gtp catabolic processGO:00061842370.034
positive regulation of phosphorylationGO:00423273940.034
regulation of nucleotide metabolic processGO:00061402690.034
membrane organizationGO:00610242920.033
lipid metabolic processGO:00066293810.032
cytoplasmic transportGO:00164823790.032
negative regulation of protein metabolic processGO:00512483910.032
vesicle mediated transportGO:00161923710.032
female gamete generationGO:000729220.032
response to abiotic stimulusGO:00096283360.031
positive regulation of cellular component organizationGO:00511303760.031
mapk cascadeGO:00001652880.031
oogenesisGO:004847720.031
regulation of transferase activityGO:00513383550.031
positive regulation of purine nucleotide catabolic processGO:00331231850.030
negative regulation of phosphate metabolic processGO:00459362670.030
rho protein signal transductionGO:0007266260.030
cellular macromolecule catabolic processGO:00442653800.030
locomotory behaviorGO:000762610.029
positive regulation of purine nucleotide metabolic processGO:19005442270.029
single organism membrane organizationGO:00448022680.029
carbohydrate metabolic processGO:00059752070.029
regulation of cellular component movementGO:00512703340.029
Human
negative regulation of cellular protein metabolic processGO:00322693530.029
regulation of gtp catabolic processGO:00331241800.029
regulation of proteolysisGO:00301622930.028
signal transduction by phosphorylationGO:00230142970.028
chemical homeostasisGO:00488783060.028
positive regulation of nucleoside metabolic processGO:00459791860.028
cellular lipid metabolic processGO:00442553030.028
actin filament based processGO:00300292240.027
positive regulation of nucleotide metabolic processGO:00459812300.027
negative regulation of phosphorus metabolic processGO:00105632670.027
regulation of cell migrationGO:00303342890.027
Human
cellular macromolecular complex assemblyGO:00346223240.027
regulation of protein kinase activityGO:00458592890.027
positive regulation of protein phosphorylationGO:00019343130.027
regulation of purine nucleotide catabolic processGO:00331212050.027
response to other organismGO:00517072610.027
cellular response to dna damage stimulusGO:00069743790.027
organonitrogen compound biosynthetic processGO:19015662000.026
regulation of nucleoside metabolic processGO:00091182090.026
response to oxygen containing compoundGO:19017003690.026
regulation of protein localizationGO:00328802960.026
nervous system developmentGO:00073992930.026
neuromuscular junction developmentGO:000752830.026
positive regulation of gtp catabolic processGO:00331261660.025
regulation of anatomical structure morphogenesisGO:00226032860.025
protein catabolic processGO:00301633250.025
sequestering of metal ionGO:0051238240.025
regenerationGO:003109940.025
positive regulation of gtpase activityGO:00435471660.025
cell activationGO:00017752130.025
response to biotic stimulusGO:00096072760.025
regulation of gtpase activityGO:00430871800.025
regulation of cell cycleGO:00517263930.025
response to external biotic stimulusGO:00432072610.024
regulation of nucleotide catabolic processGO:00308112050.024
protein maturationGO:00516042330.024
negative regulation of apoptotic processGO:00430663160.024
positive regulation of nucleotide catabolic processGO:00308131850.024
regulation of immune responseGO:00507762010.024
regulation of cellular component biogenesisGO:00440872810.024
cation transportGO:00068123310.024
regulation of kinase activityGO:00435493140.024
innate immune responseGO:00450871780.024
metal ion transportGO:00300012720.023
positive regulation of cell deathGO:00109422630.023
cellular component morphogenesisGO:00329893140.023
cell morphogenesisGO:00009022960.023
single organism cellular localizationGO:19025803320.023
negative regulation of cell deathGO:00605483450.023
carbohydrate derivative biosynthetic processGO:19011372070.023
cell projection organizationGO:00300302520.023
Human
negative regulation of multicellular organismal processGO:00512413170.022
cellular response to endogenous stimulusGO:00714953360.022
negative regulation of programmed cell deathGO:00430693210.022
regulation of cellular response to stressGO:00801352440.022
apoptotic signaling pathwayGO:00971902680.022
single organism carbohydrate metabolic processGO:00447231930.022
mitotic cell cycleGO:00002783260.022
negative regulation of hydrolase activityGO:00513461820.022
system processGO:00030083490.022
protein processingGO:00164852260.022
segmentationGO:003528240.022
maintenance of locationGO:00512351120.021
regulation of cell motilityGO:20001452990.021
Human
endomembrane system organizationGO:00102561960.021
regulation of cell cycle processGO:00105642660.021
positive regulation of cell proliferationGO:00082843010.021
enzyme linked receptor protein signaling pathwayGO:00071673030.021
oxidation reduction processGO:00551143960.021
dephosphorylationGO:00163112090.021
positive regulation of transportGO:00510503360.021
positive regulation of apoptotic processGO:00430652460.021
cellular response to oxygen containing compoundGO:19017012760.020
cell adhesionGO:00071553250.020
Human
memoryGO:000761330.020
secretion by cellGO:00329402260.020
ion homeostasisGO:00508012300.020
intracellular protein transportGO:00068862700.020
positive regulation of transferase activityGO:00513472270.020
positive regulation of locomotionGO:00400171860.020
Human
regulation of cell differentiationGO:00455953930.020
mitotic cell cycle processGO:19030472860.020
positive regulation of developmental processGO:00510943140.020
response to cytokineGO:00340972320.019
cytokine productionGO:00018162470.019
regulation of cytokine productionGO:00018172320.019
negative regulation of protein modification processGO:00314002000.019
cell developmentGO:00484683280.019
small molecule biosynthetic processGO:00442831570.019
negative regulation of cellular component organizationGO:00511292350.019
lipid biosynthetic processGO:00086101770.019
protein localization to organelleGO:00333652800.019
negative regulation of cell proliferationGO:00082852280.019
transmembrane transportGO:00550853990.019
cellular protein catabolic processGO:00442572610.019
regulation of establishment of protein localizationGO:00702012420.019
positive regulation of immune responseGO:00507781590.019
actin cytoskeleton organizationGO:00300362070.019
regulation of small gtpase mediated signal transductionGO:00510561560.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
positive regulation of organelle organizationGO:00106381950.019
regulation of peptidase activityGO:00525471800.018
spermatid differentiationGO:004851540.018
regulation of intracellular transportGO:00323861950.018
morphogenesis of embryonic epitheliumGO:001633140.018
regulation of mapk cascadeGO:00434082620.018
biological adhesionGO:00226103310.018
Human
regulation of actin filament based processGO:00329701410.018
positive regulation of mapk cascadeGO:00434101900.018
adult locomotory behaviorGO:000834410.018
sequestering of calcium ionGO:0051208170.018
cation homeostasisGO:00550801890.018
regulation of protein complex assemblyGO:00432541470.018
protein ubiquitinationGO:00165673140.018
oocyte differentiationGO:000999420.018
spermatid developmentGO:000728640.018
cellular homeostasisGO:00197251960.018
chromatin organizationGO:00063253510.017
regulation of cytoskeleton organizationGO:00514931770.017
protein oligomerizationGO:00512591730.017
regulation of locomotionGO:00400123290.017
Human
proteolysis involved in cellular protein catabolic processGO:00516032440.017
oocyte developmentGO:004859910.017
regulation of ras gtpase activityGO:00323181280.017
epithelium developmentGO:00604292270.017
cellular protein complex assemblyGO:00436231880.017
regulation of ras protein signal transductionGO:00465781550.017
regulation of response to external stimulusGO:00321012220.017
regulation of sequence specific dna binding transcription factor activityGO:00510902110.017
symbiosis encompassing mutualism through parasitismGO:00444031560.017
blastoderm segmentationGO:000735020.017
immune effector processGO:00022521590.017
purine ribonucleoside monophosphate metabolic processGO:00091671860.017
negative regulation of transportGO:00510511760.017
covalent chromatin modificationGO:00165692540.017
nucleoside monophosphate metabolic processGO:00091231910.017
actin filament organizationGO:00070151280.016
positive regulation of cellular component biogenesisGO:00440891580.016
ribonucleoside monophosphate metabolic processGO:00091611870.016
negative regulation of phosphorylationGO:00423261740.016
growthGO:00400072020.016
organophosphate biosynthetic processGO:00904071630.016
modification dependent macromolecule catabolic processGO:00436322120.016
cell growthGO:00160491600.016
positive regulation of programmed cell deathGO:00430682490.016
endosomal transportGO:00161971290.016
regulation of synaptic plasticityGO:004816730.016
negative regulation of cellular amine metabolic processGO:003323930.016
multi organism cellular processGO:00447641560.016
interspecies interaction between organismsGO:00444191560.016
negative regulation of developmental processGO:00510932470.016
reactive oxygen species metabolic processGO:0072593750.016
positive regulation of ras gtpase activityGO:00323201170.016
ion transmembrane transportGO:00342203380.016
histone modificationGO:00165702510.016
proteasomal protein catabolic processGO:00104981760.016
actin mediated cell contractionGO:0070252120.016
response to lipidGO:00339932060.016
chromatin modificationGO:00165682980.016
ubiquitin dependent protein catabolic processGO:00065112060.016
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.016
atp metabolic processGO:00460341760.015
positive regulation of cell motilityGO:20001471770.015
Human
secretionGO:00469032540.015
anterior posterior axis specificationGO:000994820.015
organic hydroxy compound metabolic processGO:19016151470.015
cell projection assemblyGO:00300311260.015
Human
motor neuron axon guidanceGO:000804520.015
negative regulation of intracellular signal transductionGO:19025321830.015
g protein coupled receptor signaling pathwayGO:00071862070.015
peptidyl tyrosine modificationGO:00182121700.015
glycoprotein metabolic processGO:00091001100.015
positive regulation of protein kinase activityGO:00458601900.015
reactive oxygen species biosynthetic processGO:190340940.015
nitrogen compound transportGO:00717051910.015
reactive nitrogen species metabolic processGO:200105730.015
protein targetingGO:00066051870.015
lymphocyte activationGO:00466491330.015
rhythmic behaviorGO:000762220.015
modification dependent protein catabolic processGO:00199412090.015
microtubule based processGO:00070172100.015
anatomical structure formation involved in morphogenesisGO:00486462840.015
establishment of protein localization to membraneGO:00901501210.015
regulation of protein catabolic processGO:00421761550.015
response to virusGO:00096151260.015
protein localization to membraneGO:00726571600.015
activation of immune responseGO:00022531140.015
cell divisionGO:00513011680.015
divalent metal ion transportGO:00708381520.015
positive regulation of kinase activityGO:00336742040.015
embryonic epithelial tube formationGO:000183840.015
divalent inorganic cation transportGO:00725111580.015
cellular response to cytokine stimulusGO:00713451810.015
anion transportGO:00068201610.015
regulation of protein maturationGO:19033171500.015
positive regulation of cell migrationGO:00303351720.015
Human
regulation of protein processingGO:00706131500.015
positive regulation of cellular component movementGO:00512721810.015
Human
posttranscriptional regulation of gene expressionGO:00106082130.015
regulation of cell growthGO:00015581350.015
response to fungusGO:000962040.015
negative regulation of cell cycleGO:00457861930.014
regulation of apoptotic signaling pathwayGO:20012331750.014
response to woundingGO:00096111680.014
cellular chemical homeostasisGO:00550821800.014
regulation of endopeptidase activityGO:00525481700.014
mitotic cell cycle phase transitionGO:00447721620.014
viral processGO:00160321460.014
immune system developmentGO:00025201950.014
neuroblast proliferationGO:000740540.014
regulation of growthGO:00400081650.014
regulation of reactive oxygen species biosynthetic processGO:190342630.014
regulation of protein serine threonine kinase activityGO:00719001790.014
tripartite regional subdivisionGO:000735120.014
regulation of secretionGO:00510461940.014
regulation of reactive oxygen species metabolic processGO:2000377410.014
circadian behaviorGO:004851220.014
neurotransmitter secretionGO:000726940.014
syncytium formation by plasma membrane fusionGO:000076820.014
viral life cycleGO:00190581320.014
positive regulation of synaptic transmissionGO:005080640.014
regulation of protein transportGO:00512232130.014
leukocyte activationGO:00453211640.014
leukocyte migrationGO:00509001070.014
cell cycle phase transitionGO:00447701730.014
neurological system processGO:00508771630.014
associative learningGO:000830610.014
compound eye developmentGO:004874910.014
mitochondrion organizationGO:00070051560.014
t cell differentiation in thymusGO:003307740.014
purine nucleoside monophosphate metabolic processGO:00091261860.014
single organism cell adhesionGO:00986021790.014
regulation of cell morphogenesisGO:00226041530.014
cell substrate adhesionGO:00315891320.014
Human
regulation of neural precursor cell proliferationGO:200017740.014
protein modification by small protein conjugationGO:00324463420.014
response to nitrogen compoundGO:19016981840.014
cell fate determinationGO:000170930.014
protein autophosphorylationGO:00467771230.014
cation transmembrane transportGO:00986552380.013
hindbrain developmentGO:003090230.013
myoblast fusionGO:000752010.013
regulation of cytoplasmic transportGO:19036491490.013
plasma membrane organizationGO:00070091150.013
positive regulation of proteolysisGO:00458621420.013
inorganic cation transmembrane transportGO:00986621940.013
response to bacteriumGO:00096171440.013
response to axon injuryGO:004867810.013
peripheral nervous system developmentGO:000742220.013
metal ion homeostasisGO:00550651690.013
regulation of actin cytoskeleton organizationGO:00329561160.013
defense response to fungusGO:005083240.013
monocarboxylic acid metabolic processGO:00327871850.013
organelle assemblyGO:00709251760.013
peptidyl tyrosine phosphorylationGO:00181081700.013
calcium ion transportGO:00068161470.013
negative regulation of protein processingGO:00109551420.013
regulation of cell activationGO:00508651250.013
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.013
hemopoiesisGO:00300971800.013
negative regulation of protein maturationGO:19033181420.013
dna repairGO:00062811980.013
immune response activating signal transductionGO:0002757900.013
cellular ion homeostasisGO:00068731680.013
neurogenesisGO:00220081690.013
purine nucleoside monophosphate catabolic processGO:00091281580.013
regulation of secretion by cellGO:19035301770.013
nucleoside phosphate biosynthetic processGO:19012931090.013
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.013
regulation of peptidyl tyrosine phosphorylationGO:00507301080.013
negative regulation of protein phosphorylationGO:00019331400.013
defense response to other organismGO:00985421290.013
nucleocytoplasmic transportGO:00069131760.013
actin filament based movementGO:0030048170.013
specification of organ identityGO:001009230.013
regulation of vesicle mediated transportGO:00606271300.013
establishment of protein localization to organelleGO:00725941720.013
negative regulation of organelle organizationGO:00106391260.013
salivary gland morphogenesisGO:000743540.013
peptidyl serine modificationGO:00182091060.013
cellular response to growth factor stimulusGO:00713631970.013
matingGO:000761810.013
anterior posterior axis specification embryoGO:000859520.012
alcohol metabolic processGO:00060661140.012
generation of neuronsGO:00486991520.012
immune response regulating signaling pathwayGO:0002764970.012
negative regulation of proteolysisGO:00458611320.012
epithelial cell differentiationGO:00308551410.012
response to organic cyclic compoundGO:00140702040.012
protein acylationGO:00435431380.012
response to growth factorGO:00708482050.012
cell part morphogenesisGO:00329901370.012
hematopoietic or lymphoid organ developmentGO:00485341860.012
cellular response to nitrogen compoundGO:19016991440.012
negative regulation of transferase activityGO:00513481240.012
inorganic ion transmembrane transportGO:00986602310.012
nucleotide biosynthetic processGO:00091651090.012
regulation of mitotic cell cycleGO:00073461890.012
organ formationGO:004864530.012
regulation of defense responseGO:00313471540.012
cellular cation homeostasisGO:00300031630.012
release of cytoplasmic sequestered nf kappabGO:000858840.012
cellular response to organonitrogen compoundGO:00714171240.012
ribonucleoside monophosphate catabolic processGO:00091581580.012
response to radiationGO:00093141510.012
regulation of multi organism processGO:00439001570.012
regulation of dna metabolic processGO:00510521530.012
sulfur compound metabolic processGO:00067901010.012
rna processingGO:00063962550.012
organelle fissionGO:00482851490.012
response to organonitrogen compoundGO:00102431560.012
neuron projection regenerationGO:003110210.012
cardiovascular system developmentGO:00723582620.012
photoreceptor cell differentiationGO:004653020.012
organic acid biosynthetic processGO:0016053970.012
meiosis iGO:000712740.012
regulation of cysteine type endopeptidase activityGO:20001161270.012
extrinsic apoptotic signaling pathwayGO:00971911190.012
positive regulation of reactive oxygen species metabolic processGO:2000379240.012
metencephalon developmentGO:002203720.012
atp catabolic processGO:00062001570.012
carboxylic acid biosynthetic processGO:0046394970.011
cell projection morphogenesisGO:00488581290.011
regulation of ion transportGO:00432691890.011
regulation of i kappab kinase nf kappab signalingGO:00431221620.011
inner ear morphogenesisGO:004247240.011
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.011
glial cell migrationGO:000834740.011
neural tube formationGO:000184130.011
divalent inorganic cation homeostasisGO:00725071360.011
rab protein signal transductionGO:003248240.011
negative regulation of cellular component movementGO:00512711060.011
endocytosisGO:00068971590.011
i kappab kinase nf kappab signalingGO:00072491660.011
ameboidal type cell migrationGO:00016671350.011
regulation of lymphocyte activationGO:00512491030.011
sensory perception of smellGO:000760820.011
tube closureGO:006060630.011
morphogenesis of a polarized epitheliumGO:000173830.011
regulation of dephosphorylationGO:0035303960.011
response to inorganic substanceGO:00100351270.011
cellular divalent inorganic cation homeostasisGO:00725031280.011
melanin metabolic processGO:000658210.011
wnt signaling pathwayGO:00160551560.011
cellular response to abiotic stimulusGO:00712141170.011
tissue regenerationGO:004224630.011
glycoprotein biosynthetic processGO:0009101910.011
cell morphogenesis involved in differentiationGO:00009041440.011
stress activated protein kinase signaling cascadeGO:0031098940.011
neuron differentiationGO:00301821380.011
cellular response to lipidGO:00713961270.011
behavioral response to ethanolGO:004814920.011
negative regulation of phosphatase activityGO:0010923610.011
limbic system developmentGO:002176130.011
cellular metal ion homeostasisGO:00068751460.011
positive regulation of protein serine threonine kinase activityGO:00719021190.011
tissue migrationGO:00901301190.011
thymus developmentGO:004853830.011
intrinsic apoptotic signaling pathwayGO:00971931270.011
nuclear transportGO:00511691790.011
purine containing compound biosynthetic processGO:0072522880.011
microtubule cytoskeleton organizationGO:00002261760.011
negative regulation of catabolic processGO:00098951040.011
positive regulation of secretionGO:00510471160.011
regulation of anatomical structure sizeGO:00900661010.011
positive regulation of reactive oxygen species biosynthetic processGO:190342820.011
positive regulation of cell differentiationGO:00455972110.011
peptidyl lysine modificationGO:00182051440.011
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.011
cardiac muscle cell contractionGO:008600340.011
regulation of metal ion transportGO:00109591200.011
regulation of meiotic cell cycleGO:005144540.011
rna interferenceGO:001624640.011
primary neural tube formationGO:001402030.011
nucleoside monophosphate catabolic processGO:00091251590.011
epidermis morphogenesisGO:004873030.011
engulfment of apoptotic cellGO:004365220.011
negative regulation of locomotionGO:00400131180.010
stress activated mapk cascadeGO:0051403930.010
negative regulation of cell migrationGO:00303361020.010
lipid localizationGO:00108761060.010
regulation of cell cycle phase transitionGO:19019871260.010
regulation of phosphatase activityGO:0010921810.010
nerve developmentGO:002167540.010
regulation of viral processGO:00507921030.010
regulation of cell developmentGO:00602841610.010
monovalent inorganic cation transportGO:00156721280.010
visual behaviorGO:000763220.010
protein homooligomerizationGO:00512601000.010
neural tube closureGO:000184330.010
regulation of leukocyte activationGO:00026941150.010
calcium ion homeostasisGO:00550741220.010
regulation of membrane potentialGO:0042391950.010
nuclear divisionGO:00002801280.010
response to salt stressGO:000965130.010
stem cell divisionGO:001714520.010
positive regulation of protein transportGO:00512221350.010
neuron developmentGO:00486661130.010
regulation of cell adhesionGO:00301551660.010
Human
establishment of planar polarityGO:000173630.010
developmental programmed cell deathGO:001062330.010
regulation of bindingGO:00510981110.010
response to oxidative stressGO:00069791210.010
protein secretionGO:0009306980.010
long term memoryGO:000761620.010

RHOF disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.024
sensory system diseaseDOID:00501552030.022
nervous system diseaseDOID:8634310.022
disease of metabolismDOID:00146672950.019
inherited metabolic disorderDOID:6552420.019
disease of cellular proliferationDOID:145661740.018
central nervous system diseaseDOID:3311860.018
immune system diseaseDOID:29141550.017
organ system cancerDOID:00506861640.016
cancerDOID:1621670.016
connective tissue diseaseDOID:651090.015
bone diseaseDOID:0080001880.015
eye and adnexa diseaseDOID:14921500.013
eye diseaseDOID:56141490.013
neurodegenerative diseaseDOID:12891020.012
muscular diseaseDOID:00800001140.011
myopathyDOID:4231040.011
muscle tissue diseaseDOID:661130.011
hematopoietic system diseaseDOID:741000.010