Homo sapiens

3 known processes

APPL2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

(Aliases: DIP13B,FLJ10659)

APPL2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
nucleoside phosphate catabolic processGO:19012924120.781
gtp metabolic processGO:00460392390.625
plasma membrane organizationGO:00070091150.604
Human
purine nucleoside triphosphate catabolic processGO:00091463920.576
purine nucleoside triphosphate metabolic processGO:00091444120.561
protein localization to plasma membraneGO:0072659930.505
Human
organophosphate catabolic processGO:00464344300.504
receptor metabolic processGO:0043112810.493
nucleoside triphosphate metabolic processGO:00091414220.468
cytoplasmic transportGO:00164823790.467
guanosine containing compound metabolic processGO:19010682440.464
nucleotide catabolic processGO:00091664080.461
ribonucleoside triphosphate catabolic processGO:00092033910.457
receptor internalizationGO:0031623430.448
gtp catabolic processGO:00061842370.448
ribonucleoside triphosphate metabolic processGO:00091994120.435
purine nucleoside catabolic processGO:00061523980.432
nucleoside triphosphate catabolic processGO:00091433940.414
exocytosisGO:0006887710.407
purine ribonucleoside metabolic processGO:00461284370.406
establishment of protein localization to membraneGO:00901501210.395
Human
endosome organizationGO:0007032200.373
membrane organizationGO:00610242920.342
Human
endomembrane system organizationGO:00102561960.342
Human
single organism membrane organizationGO:00448022680.330
Human
regulation of cellular component sizeGO:0032535820.295
cellular response to endogenous stimulusGO:00714953360.294
nucleoside catabolic processGO:00091644080.277
purine ribonucleoside catabolic processGO:00461303980.260
cellular response to nitrogen compoundGO:19016991440.247
glycosyl compound catabolic processGO:19016584130.245
vesicle mediated transportGO:00161923710.238
regulation of synaptic vesicle transportGO:190280330.229
guanosine containing compound catabolic processGO:19010692390.225
cellular response to hormone stimulusGO:00328701250.210
purine containing compound catabolic processGO:00725234110.204
single organism cellular localizationGO:19025803320.188
Human
response to hormoneGO:00097251750.186
regulation of anatomical structure sizeGO:00900661010.185
ribonucleotide catabolic processGO:00092614050.184
determination of adult lifespanGO:000834020.158
purine ribonucleoside triphosphate catabolic processGO:00092073910.156
purine ribonucleoside triphosphate metabolic processGO:00092054110.156
regulation of protein localization to plasma membraneGO:1903076400.150
Human
cellular amino acid metabolic processGO:00065201160.149
endocytosisGO:00068971590.145
regulation of cellular amino acid metabolic processGO:000652160.141
plasma membrane to endosome transportGO:004822760.139
protein localization to membraneGO:00726571600.138
Human
phagosome maturationGO:009038290.128
canonical wnt signaling pathwayGO:00600701160.122
ribonucleoside catabolic processGO:00424544060.122
response to nitrogen compoundGO:19016981840.115
post golgi vesicle mediated transportGO:0006892360.115
purine ribonucleotide catabolic processGO:00091544040.113
nervous system developmentGO:00073992930.109
synaptic vesicle exocytosisGO:001607930.106
intracellular protein transportGO:00068862700.104
purine nucleotide catabolic processGO:00061954050.102
multicellular organismal agingGO:001025930.101
mitotic cell cycleGO:00002783260.079
secretionGO:00469032540.078
regulation of protein kinase activityGO:00458592890.077
regulation of intracellular transportGO:00323861950.068
regulation of neurotransmitter secretionGO:004692830.068
carbohydrate transportGO:0008643370.067
Human
golgi to plasma membrane transportGO:0006893210.066
establishment or maintenance of apical basal cell polarityGO:003508820.064
golgi to plasma membrane protein transportGO:0043001190.063
receptor internalization involved in canonical wnt signaling pathwayGO:200028630.063
negative regulation of cellular amine metabolic processGO:003323930.062
response to oxygen containing compoundGO:19017003690.059
positive regulation of intracellular transportGO:00323881040.058
regulation of cell motilityGO:20001452990.057
regulation of establishment of protein localizationGO:00702012420.057
Human
actin cytoskeleton organizationGO:00300362070.055
post embryonic developmentGO:000979120.054
regulation of locomotionGO:00400123290.053
cell projection organizationGO:00300302520.053
neurotransmitter secretionGO:000726940.052
generation of neuronsGO:00486991520.051
peptidyl serine phosphorylationGO:00181051010.051
negative regulation of phosphorus metabolic processGO:00105632670.051
cellular response to organonitrogen compoundGO:00714171240.051
regulation of synaptic vesicle exocytosisGO:200030020.050
positive regulation of cytoplasmic transportGO:1903651820.050
neurogenesisGO:00220081690.050
response to insulinGO:0032868450.049
cellular response to oxygen containing compoundGO:19017012760.049
cell developmentGO:00484683280.049
receptor mediated endocytosisGO:0006898840.049
positive regulation of gtpase activityGO:00435471660.048
regulation of cellular ketone metabolic processGO:0010565500.047
cellular response to insulin stimulusGO:0032869410.047
positive regulation of catabolic processGO:00098963100.047
positive regulation of cell migrationGO:00303351720.047
actin filament based processGO:00300292240.046
cellular component morphogenesisGO:00329893140.045
segmentationGO:003528240.045
regulation of cell projection organizationGO:00313441070.045
rho protein signal transductionGO:0007266260.045
regulation of mitotic cell cycleGO:00073461890.045
negative regulation of catalytic activityGO:00430863350.044
cellular amine metabolic processGO:0044106410.044
negative regulation of cellular amino acid metabolic processGO:004576320.044
maintenance of locationGO:00512351120.042
regulation of gtpase activityGO:00430871800.042
mapk cascadeGO:00001652880.042
synaptic vesicle endocytosisGO:004848820.042
positive regulation of cell motilityGO:20001471770.042
protein catabolic processGO:00301633250.041
establishment or maintenance of bipolar cell polarityGO:006124520.041
regulation of cellular amine metabolic processGO:0033238110.039
carbohydrate metabolic processGO:00059752070.038
positive regulation of transportGO:00510503360.037
regulation of cellular component movementGO:00512703340.037
cellular response to peptide hormone stimulusGO:0071375560.037
positive regulation of cellular amino acid metabolic processGO:004576430.037
regulation of nucleotide metabolic processGO:00061402690.036
positive regulation of transferase activityGO:00513472270.036
regulation of exocytosisGO:0017157460.036
regulation of cell cycleGO:00517263930.036
organelle assemblyGO:00709251760.035
regulation of protein localizationGO:00328802960.035
Human
peptidyl serine modificationGO:00182091060.035
positive regulation of gtp catabolic processGO:00331261660.035
regulation of purine nucleotide catabolic processGO:00331212050.035
anatomical structure formation involved in morphogenesisGO:00486462840.034
positive regulation of cellular amine metabolic processGO:003324070.034
positive regulation of cellular catabolic processGO:00313312840.034
negative regulation of cell proliferationGO:00082852280.034
endosomal vesicle fusionGO:003405810.034
regulation of synaptic plasticityGO:004816730.034
regulation of secretion by cellGO:19035301770.034
negative regulation of phosphorylationGO:00423261740.033
endosomal transportGO:00161971290.033
positive regulation of early endosome to late endosome transportGO:200064330.032
adult locomotory behaviorGO:000834410.032
monosaccharide transportGO:0015749320.032
Human
cell part morphogenesisGO:00329901370.032
negative regulation of developmental processGO:00510932470.031
wnt signaling pathwayGO:00160551560.031
multivesicular body organizationGO:003625720.031
regulation of transferase activityGO:00513383550.031
regulation of purine nucleotide metabolic processGO:19005422640.030
organelle fissionGO:00482851490.030
dephosphorylationGO:00163112090.029
neuron projection developmentGO:00311751060.029
positive regulation of kinase activityGO:00336742040.029
memoryGO:000761330.029
response to cytokineGO:00340972320.029
amine metabolic processGO:0009308440.029
positive regulation of purine nucleotide catabolic processGO:00331231850.029
mitotic cell cycle processGO:19030472860.029
cellular component assembly involved in morphogenesisGO:0010927730.029
response to peptideGO:1901652650.028
cellular lipid metabolic processGO:00442553030.028
cation transportGO:00068123310.028
metal ion transportGO:00300012720.028
glycoprotein biosynthetic processGO:0009101910.027
positive regulation of cell differentiationGO:00455972110.027
regulation of peptidyl serine phosphorylationGO:0033135500.027
ras protein signal transductionGO:0007265730.027
signal releaseGO:0023061700.027
negative regulation of phosphate metabolic processGO:00459362670.027
regulation of gtp catabolic processGO:00331241800.027
regulation of cytoskeleton organizationGO:00514931770.027
positive regulation of purine nucleotide metabolic processGO:19005442270.027
ribonucleoside monophosphate catabolic processGO:00091581580.026
histone modificationGO:00165702510.026
regulation of cell developmentGO:00602841610.026
regulation of cytokine productionGO:00018172320.026
embryonic epithelial tube formationGO:000183840.026
positive regulation of cellular component movementGO:00512721810.026
hexose transportGO:0008645300.026
Human
morphogenesis of embryonic epitheliumGO:001633140.025
cellular ketone metabolic processGO:0042180800.025
cytokinesisGO:0000910960.025
cellular macromolecular complex assemblyGO:00346223240.025
regulation of actin filament based processGO:00329701410.025
negative regulation of cellular protein metabolic processGO:00322693530.025
limbic system developmentGO:002176130.025
circulatory system developmentGO:00723592620.025
cell divisionGO:00513011680.025
carbohydrate derivative biosynthetic processGO:19011372070.025
covalent chromatin modificationGO:00165692540.024
cell cycle phase transitionGO:00447701730.024
regulated secretory pathwayGO:0045055200.024
negative regulation of programmed cell deathGO:00430693210.024
organelle fusionGO:0048284360.024
system processGO:00030083490.024
regulation of ras protein signal transductionGO:00465781550.024
signal transduction by phosphorylationGO:00230142970.024
neurological system processGO:00508771630.024
positive regulation of nucleotide metabolic processGO:00459812300.024
purine ribonucleoside monophosphate metabolic processGO:00091671860.024
lipid modificationGO:0030258840.023
regulation of kinase activityGO:00435493140.023
regulation of ras gtpase activityGO:00323181280.023
proteasomal protein catabolic processGO:00104981760.023
behavioral response to ethanolGO:004814920.023
negative regulation of cell cycle phase transitionGO:1901988890.023
response to woundingGO:00096111680.023
positive regulation of ras gtpase activityGO:00323201170.022
oogenesisGO:004847720.022
organelle inheritanceGO:004830820.022
nucleus localizationGO:005164710.022
positive regulation of protein kinase activityGO:00458601900.022
cell morphogenesisGO:00009022960.022
anterior posterior axis specificationGO:000994820.022
regulation of endocytosisGO:0030100720.022
protein localization to organelleGO:00333652800.022
chromatin modificationGO:00165682980.021
actin filament organizationGO:00070151280.021
multi organism cellular processGO:00447641560.021
regulation of establishment of protein localization to plasma membraneGO:0090003300.021
Human
positive regulation of cell proliferationGO:00082843010.021
lipid metabolic processGO:00066293810.021
positive regulation of cell deathGO:00109422630.021
vacuole organizationGO:0007033440.021
cell fate determinationGO:000170930.021
wound healingGO:00420601150.021
nuclear migrationGO:000709710.021
response to peptide hormoneGO:0043434610.021
negative regulation of hydrolase activityGO:00513461820.020
response to lipidGO:00339932060.020
negative regulation of apoptotic processGO:00430663160.020
regulation of rho protein signal transductionGO:0035023790.020
glycerolipid metabolic processGO:00464861070.020
regulation of cell migrationGO:00303342890.020
reactive oxygen species biosynthetic processGO:190340940.020
regulation of cytoplasmic transportGO:19036491490.020
golgi vesicle transportGO:0048193800.020
photoreceptor cell differentiationGO:004653020.020
organ formationGO:004864530.020
regulation of neuronal synaptic plasticityGO:004816810.020
single organism carbohydrate metabolic processGO:00447231930.020
organ morphogenesisGO:00098871470.020
phospholipid metabolic processGO:0006644990.020
glycerophospholipid metabolic processGO:0006650840.020
positive regulation of reactive oxygen species metabolic processGO:2000379240.020
regulation of nucleoside metabolic processGO:00091182090.020
negative regulation of cell cycleGO:00457861930.020
cellular protein complex assemblyGO:00436231880.019
protein autophosphorylationGO:00467771230.019
female gamete generationGO:000729220.019
modification dependent protein catabolic processGO:00199412090.019
blastoderm segmentationGO:000735020.019
negative regulation of mitotic cell cycleGO:00459301020.019
spermatid differentiationGO:004851540.019
negative regulation of protein metabolic processGO:00512483910.019
negative regulation of cell cycle processGO:00109481210.019
regulation of vesicle mediated transportGO:00606271300.018
organelle localizationGO:0051640840.018
protein secretionGO:0009306980.018
regulation of epithelial cell migrationGO:0010632930.018
neuroblast proliferationGO:000740540.018
reactive oxygen species metabolic processGO:0072593750.018
positive regulation of cellular component organizationGO:00511303760.018
cell adhesionGO:00071553250.018
regulation of autophagyGO:0010506520.018
glycoprotein metabolic processGO:00091001100.018
tissue regenerationGO:004224630.018
neural tube formationGO:000184130.018
cell projection morphogenesisGO:00488581290.018
motor neuron axon guidanceGO:000804520.018
cell growthGO:00160491600.018
associative learningGO:000830610.018
cilium organizationGO:0044782680.018
spermatid developmentGO:000728640.018
single organism membrane fusionGO:0044801370.018
regulation of cellular response to stressGO:00801352440.018
macromolecule methylationGO:0043414970.018
regulation of reactive oxygen species biosynthetic processGO:190342630.017
negative regulation of protein modification processGO:00314002000.017
cellular response to growth factor stimulusGO:00713631970.017
positive regulation of locomotionGO:00400171860.017
rna interferenceGO:001624640.017
positive regulation of protein phosphorylationGO:00019343130.017
cellular homeostasisGO:00197251960.017
nuclear transportGO:00511691790.017
meiotic chromosome segregationGO:004513240.017
epithelial cell migrationGO:00106311190.017
regulation of anatomical structure morphogenesisGO:00226032860.017
neuromuscular junction developmentGO:000752830.017
interspecies interaction between organismsGO:00444191560.017
negative regulation of cell deathGO:00605483450.017
positive regulation of immune system processGO:00026842830.017
regulation of axon extension involved in axon guidanceGO:004884120.017
neural tube closureGO:000184330.017
epithelium migrationGO:00901321190.017
locomotory behaviorGO:000762610.017
positive regulation of hydrolase activityGO:00513453310.017
positive regulation of nucleoside metabolic processGO:00459791860.017
hindbrain developmentGO:003090230.017
symbiosis encompassing mutualism through parasitismGO:00444031560.016
regulation of growthGO:00400081650.016
response to abiotic stimulusGO:00096283360.016
ectodermal placode formationGO:006078810.016
regulation of cell morphogenesisGO:00226041530.016
positive regulation of developmental processGO:00510943140.016
epithelial cell differentiationGO:00308551410.016
negative regulation of protein phosphorylationGO:00019331400.016
epithelium developmentGO:00604292270.016
regulation of reactive oxygen species metabolic processGO:2000377410.016
positive regulation of phosphorylationGO:00423273940.016
engulfment of apoptotic cellGO:004365220.016
positive regulation of apoptotic processGO:00430652460.016
regulation of protein serine threonine kinase activityGO:00719001790.016
peripheral nervous system developmentGO:000742220.016
atp catabolic processGO:00062001570.016
protein glycosylationGO:0006486620.016
glycosylationGO:0070085710.016
ion transmembrane transportGO:00342203380.016
regulation of proteolysisGO:00301622930.016
protein targetingGO:00066051870.016
g1 s transition of mitotic cell cycleGO:0000082780.016
inner ear morphogenesisGO:004247240.016
blood vessel morphogenesisGO:00485141620.016
regulation of cell projection assemblyGO:0060491470.016
negative regulation of multicellular organismal processGO:00512413170.016
mitotic nuclear divisionGO:00070671190.015
lipid localizationGO:00108761060.015
regulation of rho gtpase activityGO:0032319660.015
rhythmic behaviorGO:000762220.015
chromatin organizationGO:00063253510.015
posttranscriptional regulation of gene expressionGO:00106082130.015
positive regulation of reactive oxygen species biosynthetic processGO:190342820.015
regulation of actin cytoskeleton organizationGO:00329561160.015
single organism reproductive processGO:0044702980.015
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.015
cell type specific apoptotic processGO:00972851250.015
fatty acid metabolic processGO:00066311150.015
regulation of dephosphorylationGO:0035303960.015
ribonucleoside monophosphate metabolic processGO:00091611870.015
positive regulation of cytokine productionGO:00018191670.015
positive regulation of mapk cascadeGO:00434101900.015
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.015
negative regulation of cell growthGO:0030308830.015
regulation of mapk cascadeGO:00434082620.015
cytokine productionGO:00018162470.015
regulation of cell adhesionGO:00301551660.015
regulation of neurogenesisGO:0050767820.015
biological adhesionGO:00226103310.015
viral processGO:00160321460.015
regenerationGO:003109940.014
positive regulation of programmed cell deathGO:00430682490.014
histone methylationGO:0016571600.014
organophosphate biosynthetic processGO:00904071630.014
modification dependent macromolecule catabolic processGO:00436322120.014
establishment of protein localization to organelleGO:00725941720.014
negative regulation of rho gtpase activityGO:003425940.014
mitotic cell cycle phase transitionGO:00447721620.014
anion transportGO:00068201610.014
secretion by cellGO:00329402260.014
nucleoside monophosphate metabolic processGO:00091231910.014
matingGO:000761810.014
reactive nitrogen species metabolic processGO:200105730.014
macromolecule glycosylationGO:0043413630.014
regulation of cell differentiationGO:00455953930.014
cell projection assemblyGO:00300311260.014
tube closureGO:006060630.014
chemotaxisGO:00069351570.014
regulation of protein complex assemblyGO:00432541470.014
apoptotic signaling pathwayGO:00971902680.014
purine nucleoside monophosphate metabolic processGO:00091261860.014
central nervous system neuron axonogenesisGO:002195530.014
establishment of organelle localizationGO:0051656590.014
regulation of cellular component biogenesisGO:00440872810.014
sex determinationGO:000753030.014
hemopoiesisGO:00300971800.014
cellular response to cytokine stimulusGO:00713451810.014
transmembrane transportGO:00550853990.014
hippocampus developmentGO:002176610.014
ubiquitin dependent protein catabolic processGO:00065112060.014
nucleocytoplasmic transportGO:00069131760.014
negative regulation of cell motilityGO:20001461040.014
metencephalon developmentGO:002203720.013
negative regulation of locomotionGO:00400131180.013
meiosis iGO:000712740.013
peptidyl tyrosine phosphorylationGO:00181081700.013
positive regulation of organelle organizationGO:00106381950.013
protein ubiquitinationGO:00165673140.013
cellular protein catabolic processGO:00442572610.013
regulation of neural precursor cell proliferationGO:200017740.013
negative regulation of cell developmentGO:0010721480.013
atp metabolic processGO:00460341760.013
stem cell divisionGO:001714520.013
nuclear divisionGO:00002801280.013
tube developmentGO:00352951250.013
cilium morphogenesisGO:0060271750.013
positive regulation of endocytosisGO:0045807420.013
methylationGO:00322591060.013
epithelial cell proliferationGO:00506731280.013
sequestering of metal ionGO:0051238240.013
late endosome to vacuole transportGO:004532420.013
proteolysis involved in cellular protein catabolic processGO:00516032440.013
small gtpase mediated signal transductionGO:0007264780.013
primary neural tube formationGO:001402030.013
positive regulation of rho gtpase activityGO:0032321560.013
regulation of viral processGO:00507921030.013
synaptic vesicle recyclingGO:003646530.013
organonitrogen compound biosynthetic processGO:19015662000.013
protein oligomerizationGO:00512591730.012
cardiovascular system developmentGO:00723582620.012
morphogenesis of a polarized epitheliumGO:000173830.012
regulation of ion transportGO:00432691890.012
central nervous system developmentGO:00074171230.012
regulation of endopeptidase activityGO:00525481700.012
negative regulation of intracellular signal transductionGO:19025321830.012
regulation of dna metabolic processGO:00510521530.012
immune responseGO:00069553070.012
regulation of mitotic cell cycle phase transitionGO:19019901180.012
positive regulation of protein transportGO:00512221350.012
cellular macromolecule catabolic processGO:00442653800.012
regulation of apoptotic signaling pathwayGO:20012331750.012
positive regulation of axon extensionGO:004577340.012
negative regulation of blood pressureGO:004577630.012
cellular response to external stimulusGO:00714961110.012
protein acylationGO:00435431380.012
positive regulation of cell cycleGO:00457871400.012
chromosome segregationGO:00070591140.012
regulation of cysteine type endopeptidase activityGO:20001161270.012
somitogenesisGO:000175620.012
cell cycle g1 s phase transitionGO:0044843800.012
calcium ion transportGO:00068161470.012
cellular component disassemblyGO:0022411920.012
regulation of nucleotide catabolic processGO:00308112050.012
rab protein signal transductionGO:003248240.012
establishment or maintenance of cell polarityGO:0007163310.012
immune system developmentGO:00025201950.012
tube morphogenesisGO:0035239950.012
cellular response to extracellular stimulusGO:0031668720.012
agingGO:0007568660.012
membrane fusionGO:0061025430.012
protein maturationGO:00516042330.012
peptidyl tyrosine modificationGO:00182121700.011
peptidyl lysine modificationGO:00182051440.011
regulation of cell cycle processGO:00105642660.011
antigen processing and presentationGO:0019882330.011
peptidyl threonine modificationGO:0018210450.011
tongue developmentGO:004358610.011
negative regulation of phosphatase activityGO:0010923610.011
regulation of carbohydrate metabolic processGO:0006109540.011
negative regulation of cell migrationGO:00303361020.011
negative regulation of protein kinase activityGO:0006469980.011
brain developmentGO:0007420970.011
embryo developmentGO:00097901230.011
autophagyGO:0006914880.011
cation transmembrane transportGO:00986552380.011
actin filament based movementGO:0030048170.011
regulation of protein polymerizationGO:0032271630.011
regulation of epithelial cell proliferationGO:00506781130.011
innate immune responseGO:00450871780.011
positive regulation of peptidase activityGO:0010952880.011
negative regulation of growthGO:0045926970.011
vasculature developmentGO:00019441810.011
ameboidal type cell migrationGO:00016671350.011
sleepGO:003043120.011
regulation of protein transportGO:00512232130.011
negative regulation of cellular catabolic processGO:0031330830.011
blood vessel developmentGO:00015681720.011
brain morphogenesisGO:004885410.011
hematopoietic or lymphoid organ developmentGO:00485341860.011
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.011
head developmentGO:00603221080.011
cellular response to nutrient levelsGO:0031669690.011
central nervous system projection neuron axonogenesisGO:002195230.011
endocardial cushion developmentGO:000319730.011
regulation of sarcomere organizationGO:006029730.011
histone acetylationGO:0016573930.011
negative regulation of synaptic transmissionGO:005080520.011
visual behaviorGO:000763220.011

APPL2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.034
cancerDOID:1621670.034
organ system cancerDOID:00506861640.034
disease of cellular proliferationDOID:145661740.034
musculoskeletal system diseaseDOID:172230.029
cardiovascular system diseaseDOID:12871060.025
muscular diseaseDOID:00800001140.023
central nervous system diseaseDOID:3311860.019
nervous system diseaseDOID:8634310.019
sensory system diseaseDOID:00501552030.015
myopathyDOID:4231040.014
muscular dystrophyDOID:9884510.014
muscle tissue diseaseDOID:661130.014
connective tissue diseaseDOID:651090.014
immune system diseaseDOID:29141550.014
heart diseaseDOID:114680.013
brain diseaseDOID:936730.012
gastrointestinal system cancerDOID:3119520.012
hematopoietic system diseaseDOID:741000.011
eye and adnexa diseaseDOID:14921500.011