Homo sapiens

0 known processes

NKX2-4

NK2 homeobox 4

(Aliases: NKX2D,NKX2.4)

NKX2-4 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
extraocular skeletal muscle developmentGO:000207410.135
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.085
Human
post embryonic developmentGO:000979120.080
cellular amine metabolic processGO:0044106410.062
cellular ketone metabolic processGO:0042180800.059
regulation of anatomical structure morphogenesisGO:00226032860.058
Human
regulation of cellular amino acid metabolic processGO:000652160.055
organ formationGO:004864530.055
organ morphogenesisGO:00098871470.055
Human
regulation of cellular ketone metabolic processGO:0010565500.053
negative regulation of multicellular organismal processGO:00512413170.053
Human
amine metabolic processGO:0009308440.052
regulation of cell differentiationGO:00455953930.052
Human
cranial nerve developmentGO:002154540.049
cellular amino acid metabolic processGO:00065201160.049
anatomical structure formation involved in morphogenesisGO:00486462840.048
neuron fate commitmentGO:004866320.047
positive regulation of cellular amino acid metabolic processGO:004576430.046
regulation of cellular amine metabolic processGO:0033238110.045
cell morphogenesisGO:00009022960.045
Human Fly
cellular component morphogenesisGO:00329893140.044
Human Fly
positive regulation of cellular amine metabolic processGO:003324070.043
nervous system developmentGO:00073992930.042
Human Fly
cardiovascular system developmentGO:00723582620.042
Human
circulatory system developmentGO:00723592620.042
Human
regulation of cell cycleGO:00517263930.041
positive regulation of cell proliferationGO:00082843010.039
negative regulation of protein metabolic processGO:00512483910.038
enzyme linked receptor protein signaling pathwayGO:00071673030.037
Human
vasculature developmentGO:00019441810.037
cellular response to endogenous stimulusGO:00714953360.036
Human
segmentationGO:003528240.036
negative regulation of cellular protein metabolic processGO:00322693530.036
epithelium developmentGO:00604292270.035
Human
multicellular organismal agingGO:001025930.034
spinal cord developmentGO:002151040.034
nerve developmentGO:002167540.034
regulation of locomotionGO:00400123290.034
Human
regulation of cellular component movementGO:00512703340.034
Human
mitotic cell cycleGO:00002783260.033
system processGO:00030083490.033
negative regulation of developmental processGO:00510932470.033
Human
cell developmentGO:00484683280.033
Human Fly
menstrual cycle phaseGO:002260120.032
cell fate determinationGO:000170930.032
negative regulation of cell differentiationGO:00455961710.032
Human
positive regulation of developmental processGO:00510943140.031
Human
regulation of cell motilityGO:20001452990.031
Human
negative regulation of programmed cell deathGO:00430693210.030
Human
positive regulation of cell deathGO:00109422630.030
negative regulation of cell deathGO:00605483450.030
Human
hematopoietic or lymphoid organ developmentGO:00485341860.029
Human
locomotory behaviorGO:000762610.029
immune system developmentGO:00025201950.029
Human
lipid metabolic processGO:00066293810.029
female gamete generationGO:000729220.029
determination of adult lifespanGO:000834020.028
cell morphogenesis involved in differentiationGO:00009041440.028
Human Fly
negative regulation of phosphorus metabolic processGO:00105632670.028
neuron differentiationGO:00301821380.028
Human Fly
positive regulation of apoptotic processGO:00430652460.028
regulation of kinase activityGO:00435493140.028
central nervous system developmentGO:00074171230.027
Human
response to oxygen containing compoundGO:19017003690.027
generation of neuronsGO:00486991520.027
Human Fly
negative regulation of catalytic activityGO:00430863350.027
cell projection organizationGO:00300302520.027
Fly
oogenesisGO:004847720.027
tube developmentGO:00352951250.026
Human
negative regulation of cell cycleGO:00457861930.026
positive regulation of transportGO:00510503360.026
regulation of mitotic cell cycleGO:00073461890.026
regulation of transferase activityGO:00513383550.026
digestive system developmentGO:0055123750.025
positive regulation of hydrolase activityGO:00513453310.025
negative regulation of phosphate metabolic processGO:00459362670.025
cell cell signalingGO:00072671550.025
blood vessel developmentGO:00015681720.025
regulation of proteolysisGO:00301622930.025
embryonic morphogenesisGO:0048598850.025
cellular macromolecule catabolic processGO:00442653800.025
negative regulation of apoptotic processGO:00430663160.025
Human
biological adhesionGO:00226103310.025
cellular response to dna damage stimulusGO:00069743790.025
morphogenesis of embryonic epitheliumGO:001633140.025
positive regulation of cellular component organizationGO:00511303760.024
negative regulation of cellular component organizationGO:00511292350.024
Human
head developmentGO:00603221080.024
Human
positive regulation of programmed cell deathGO:00430682490.024
single organism cellular localizationGO:19025803320.023
immune responseGO:00069553070.023
regulation of sequence specific dna binding transcription factor activityGO:00510902110.023
response to abiotic stimulusGO:00096283360.023
protein localization to organelleGO:00333652800.023
mesenchyme developmentGO:0060485590.023
Human
epithelial cell differentiationGO:00308551410.023
cellular response to growth factor stimulusGO:00713631970.023
Human
regulation of protein kinase activityGO:00458592890.023
pharynx developmentGO:006046510.023
actin filament based processGO:00300292240.023
specification of organ identityGO:001009230.022
hindbrain developmentGO:003090230.022
regulation of cell cycle processGO:00105642660.022
membrane organizationGO:00610242920.022
thymus developmentGO:004853830.022
positive regulation of cell cycleGO:00457871400.022
cell adhesionGO:00071553250.022
neurogenesisGO:00220081690.021
Human Fly
regulation of cell developmentGO:00602841610.021
Human
negative regulation of cell proliferationGO:00082852280.021
negative regulation of protein modification processGO:00314002000.021
regulation of cytokine productionGO:00018172320.021
regulation of protein localizationGO:00328802960.020
stem cell differentiationGO:0048863930.020
Human
regulation of cellular response to stressGO:00801352440.020
cell differentiation in spinal cordGO:002151510.020
skeletal system developmentGO:0001501790.020
protein catabolic processGO:00301633250.020
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.020
purine ribonucleoside metabolic processGO:00461284370.020
positive regulation of protein phosphorylationGO:00019343130.020
organophosphate catabolic processGO:00464344300.020
ribonucleoside triphosphate catabolic processGO:00092033910.020
secretionGO:00469032540.020
single organism membrane organizationGO:00448022680.020
cell divisionGO:00513011680.020
positive regulation of phosphorylationGO:00423273940.020
response to hormoneGO:00097251750.020
Human
regulation of endopeptidase activityGO:00525481700.020
regulation of cell migrationGO:00303342890.020
Human
regulation of establishment of protein localizationGO:00702012420.019
brain developmentGO:0007420970.019
Human
cytoplasmic transportGO:00164823790.019
secretion by cellGO:00329402260.019
apoptotic signaling pathwayGO:00971902680.019
signal transduction by phosphorylationGO:00230142970.019
growthGO:00400072020.019
regulation of peptidase activityGO:00525471800.019
mitotic cell cycle processGO:19030472860.019
tissue morphogenesisGO:0048729960.019
Human
regulation of cell morphogenesisGO:00226041530.019
Human
cellular response to oxygen containing compoundGO:19017012760.019
oxidation reduction processGO:00551143960.018
mapk cascadeGO:00001652880.018
stem cell developmentGO:0048864690.018
Human
ras protein signal transductionGO:0007265730.018
ribonucleoside catabolic processGO:00424544060.018
small gtpase mediated signal transductionGO:0007264780.018
nucleoside phosphate catabolic processGO:19012924120.018
positive regulation of catabolic processGO:00098963100.018
regulation of secretionGO:00510461940.018
purine nucleoside triphosphate metabolic processGO:00091444120.018
positive regulation of cell differentiationGO:00455972110.018
Human
cytokine productionGO:00018162470.018
negative regulation of intracellular signal transductionGO:19025321830.018
muscle structure developmentGO:0061061980.018
Human
peripheral nervous system developmentGO:000742220.018
cellular lipid metabolic processGO:00442553030.017
ribonucleoside triphosphate metabolic processGO:00091994120.017
regulation of response to external stimulusGO:00321012220.017
negative regulation of phosphorylationGO:00423261740.017
positive regulation of organelle organizationGO:00106381950.017
blood vessel morphogenesisGO:00485141620.017
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.017
cellular response to hormone stimulusGO:00328701250.017
positive regulation of cellular catabolic processGO:00313312840.017
purine containing compound catabolic processGO:00725234110.017
response to woundingGO:00096111680.017
vesicle mediated transportGO:00161923710.017
glycosyl compound catabolic processGO:19016584130.017
nucleoside triphosphate metabolic processGO:00091414220.017
purine ribonucleoside triphosphate catabolic processGO:00092073910.017
mesenchymal cell developmentGO:0014031500.017
Human
positive regulation of immune system processGO:00026842830.017
regulation of neural precursor cell proliferationGO:200017740.017
regulation of stem cell differentiationGO:2000736560.017
Human
purine ribonucleotide catabolic processGO:00091544040.017
purine nucleoside triphosphate catabolic processGO:00091463920.017
transmembrane transportGO:00550853990.017
ribonucleotide catabolic processGO:00092614050.017
embryonic epithelial tube formationGO:000183840.017
cellular protein catabolic processGO:00442572610.016
regulation of cysteine type endopeptidase activityGO:20001161270.016
heart developmentGO:0007507950.016
Human
protein maturationGO:00516042330.016
protein localization to membraneGO:00726571600.016
positive regulation of protein kinase activityGO:00458601900.016
chemical homeostasisGO:00488783060.016
response to lipidGO:00339932060.016
muscle tissue developmentGO:0060537620.016
Human
nucleotide catabolic processGO:00091664080.016
intracellular protein transportGO:00068862700.016
chromatin organizationGO:00063253510.016
purine ribonucleoside triphosphate metabolic processGO:00092054110.016
regulation of cell growthGO:00015581350.016
regulation of cellular component biogenesisGO:00440872810.016
positive regulation of transferase activityGO:00513472270.016
single organism cell adhesionGO:00986021790.016
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.016
regulation of dna metabolic processGO:00510521530.016
menstruationGO:004270310.016
angiogenesisGO:00015251470.016
neuromuscular junction developmentGO:000752830.016
cell projection morphogenesisGO:00488581290.016
Fly
positive regulation of cytokine productionGO:00018191670.016
embryo developmentGO:00097901230.016
Human Worm
negative regulation of locomotionGO:00400131180.016
Human
regulation of apoptotic signaling pathwayGO:20012331750.016
regulation of secretion by cellGO:19035301770.015
negative regulation of protein phosphorylationGO:00019331400.015
protein ubiquitinationGO:00165673140.015
innate immune responseGO:00450871780.015
nucleoside triphosphate catabolic processGO:00091433940.015
regulation of growthGO:00400081650.015
pattern specification processGO:0007389430.015
regulation of protein transportGO:00512232130.015
cation transportGO:00068123310.015
blastoderm segmentationGO:000735020.015
posttranscriptional regulation of gene expressionGO:00106082130.015
nucleocytoplasmic transportGO:00069131760.015
cell part morphogenesisGO:00329901370.015
Fly
cellular response to nitrogen compoundGO:19016991440.015
response to organic cyclic compoundGO:00140702040.015
positive regulation of locomotionGO:00400171860.015
negative regulation of cellular amino acid metabolic processGO:004576320.015
defense responseGO:00069523150.015
embryonic camera type eye developmentGO:003107620.015
regulation of cell morphogenesis involved in differentiationGO:0010769830.015
Human
regulation of nucleotide metabolic processGO:00061402690.015
nitrogen compound transportGO:00717051910.015
dephosphorylationGO:00163112090.015
negative regulation of cell developmentGO:0010721480.015
Human
positive regulation of kinase activityGO:00336742040.015
purine ribonucleoside catabolic processGO:00461303980.015
endomembrane system organizationGO:00102561960.015
morphogenesis of an epitheliumGO:0002009600.015
Human
cellular response to cytokine stimulusGO:00713451810.015
positive regulation of peptidase activityGO:0010952880.015
positive regulation of cellular component movementGO:00512721810.015
proteolysis involved in cellular protein catabolic processGO:00516032440.015
protein processingGO:00164852260.015
cellular macromolecular complex assemblyGO:00346223240.014
negative regulation of cellular amine metabolic processGO:003323930.014
spermatid differentiationGO:004851540.014
microtubule based processGO:00070172100.014
regulation of mapk cascadeGO:00434082620.014
nucleoside catabolic processGO:00091644080.014
cell growthGO:00160491600.014
regenerationGO:003109940.014
protein modification by small protein conjugationGO:00324463420.014
tube morphogenesisGO:0035239950.014
Human
regulation of protein serine threonine kinase activityGO:00719001790.014
chromatin modificationGO:00165682980.014
compound eye developmentGO:004874910.014
positive regulation of proteolysisGO:00458621420.014
hemostasisGO:0007599760.014
regulation of intracellular transportGO:00323861950.014
oocyte developmentGO:004859910.014
regulation of body fluid levelsGO:0050878990.014
purine nucleoside catabolic processGO:00061523980.014
positive regulation of secretionGO:00510471160.014
positive regulation of secretion by cellGO:19035321080.014
soft palate developmentGO:006002330.014
response to growth factorGO:00708482050.014
Human
nuclear transportGO:00511691790.014
response to external biotic stimulusGO:00432072610.014
hard palate developmentGO:006002210.014
epithelial cell proliferationGO:00506731280.014
regulation of hormone levelsGO:00108171250.014
single organism reproductive processGO:0044702980.014
protein targetingGO:00066051870.014
intracellular receptor signaling pathwayGO:00305221040.014
positive regulation of nucleotide metabolic processGO:00459812300.014
digestive tract developmentGO:0048565750.014
negative regulation of hydrolase activityGO:00513461820.014
mesenchymal cell differentiationGO:0048762520.014
Human
reproductive processGO:00224141060.013
response to other organismGO:00517072610.013
positive regulation of cell developmentGO:0010720920.013
Human
establishment of protein localization to organelleGO:00725941720.013
purine nucleotide catabolic processGO:00061954050.013
response to cytokineGO:00340972320.013
inner ear morphogenesisGO:004247240.013
wnt signaling pathwayGO:00160551560.013
regulation of wnt signaling pathwayGO:00301111230.013
response to biotic stimulusGO:00096072760.013
ossificationGO:00015031210.013
negative regulation of transferase activityGO:00513481240.013
oocyte differentiationGO:000999420.013
anterior posterior axis specificationGO:000994820.013
metencephalon developmentGO:002203720.013
positive regulation of cellular component biogenesisGO:00440891580.013
cell activationGO:00017752130.013
positive regulation of cell motilityGO:20001471770.013
somitogenesisGO:000175620.013
hemopoiesisGO:00300971800.013
memoryGO:000761330.013
protein oligomerizationGO:00512591730.013
negative regulation of protein processingGO:00109551420.013
regulation of protein complex assemblyGO:00432541470.013
negative regulation of cell motilityGO:20001461040.013
Human
cellular homeostasisGO:00197251960.013
rho protein signal transductionGO:0007266260.013
lipid biosynthetic processGO:00086101770.013
histone modificationGO:00165702510.013
modification dependent protein catabolic processGO:00199412090.012
ion transmembrane transportGO:00342203380.012
metal ion transportGO:00300012720.012
regulation of response to woundingGO:19030341010.012
regulation of cell adhesionGO:00301551660.012
organic hydroxy compound metabolic processGO:19016151470.012
actin cytoskeleton organizationGO:00300362070.012
carbohydrate metabolic processGO:00059752070.012
regulation of protein maturationGO:19033171500.012
dna repairGO:00062811980.012
heart morphogenesisGO:0003007480.012
Human
neuron projection developmentGO:00311751060.012
Fly
negative regulation of cell migrationGO:00303361020.012
Human
positive regulation of cell migrationGO:00303351720.012
response to nitrogen compoundGO:19016981840.012
positive regulation of endopeptidase activityGO:0010950840.012
monocarboxylic acid metabolic processGO:00327871850.012
peptidyl tyrosine modificationGO:00182121700.012
positive regulation of purine nucleotide metabolic processGO:19005442270.012
single organism carbohydrate metabolic processGO:00447231930.012
regulation of protein processingGO:00706131500.012
regulation of epithelial to mesenchymal transitionGO:0010717370.012
Human
ion homeostasisGO:00508012300.012
rna processingGO:00063962550.012
blood coagulationGO:0007596760.012
protein localization to nucleusGO:00345041360.012
regulation of purine nucleotide metabolic processGO:19005422640.012
neural crest cell developmentGO:001403230.012
nucleoside monophosphate metabolic processGO:00091231910.012
proteasomal protein catabolic processGO:00104981760.012
neural tube formationGO:000184130.012
regulation of immune responseGO:00507762010.012
blastocyst developmentGO:000182430.012
spermatid developmentGO:000728640.012
cation transmembrane transportGO:00986552380.012
reactive oxygen species metabolic processGO:0072593750.012
small molecule biosynthetic processGO:00442831570.012
regulation of cell divisionGO:00513021160.012
negative regulation of organelle organizationGO:00106391260.012
positive regulation of cysteine type endopeptidase activityGO:2001056790.012
cardiac right ventricle morphogenesisGO:000321530.012
Human
cell cycle phase transitionGO:00447701730.012
negative regulation of cellular component movementGO:00512711060.012
Human
positive regulation of neural precursor cell proliferationGO:200017920.012
muscle organ developmentGO:0007517560.012
Human
positive regulation of protein transportGO:00512221350.012
negative regulation of growthGO:0045926970.012
organonitrogen compound biosynthetic processGO:19015662000.012
regulation of purine nucleotide catabolic processGO:00331212050.011
regulation of vasculature developmentGO:1901342970.011
covalent chromatin modificationGO:00165692540.011
positive regulation of purine nucleotide catabolic processGO:00331231850.011
negative regulation of mitotic cell cycleGO:00459301020.011
cellular response to organonitrogen compoundGO:00714171240.011
neuroblast proliferationGO:000740540.011
response to organonitrogen compoundGO:00102431560.011
cerebellum developmentGO:002154920.011
cell projection assemblyGO:00300311260.011
wound healingGO:00420601150.011
carbohydrate derivative biosynthetic processGO:19011372070.011
regulation of reactive oxygen species metabolic processGO:2000377410.011
taxisGO:00423301570.011
negative regulation of kinase activityGO:00336731060.011
forelimb morphogenesisGO:003513640.011
regulation of nucleoside metabolic processGO:00091182090.011
modification dependent macromolecule catabolic processGO:00436322120.011
ubiquitin dependent protein catabolic processGO:00065112060.011
response to decreased oxygen levelsGO:0036293960.011
canonical wnt signaling pathwayGO:00600701160.011
tripartite regional subdivisionGO:000735120.011
negative regulation of protein kinase activityGO:0006469980.011
positive regulation of nucleoside metabolic processGO:00459791860.011
nucleic acid phosphodiester bond hydrolysisGO:00903051020.011
coagulationGO:0050817780.011
chemotaxisGO:00069351570.011
microtubule cytoskeleton organizationGO:00002261760.011
adult locomotory behaviorGO:000834410.011
positive regulation of cell divisionGO:0051781590.011
positive regulation of mitotic cell cycleGO:0045931600.011
regulation of protein catabolic processGO:00421761550.011
response to hypoxiaGO:0001666960.011
negative regulation of protein maturationGO:19033181420.011
mesodermal cell fate commitmentGO:000171020.011
maintenance of locationGO:00512351120.011
epithelial to mesenchymal transitionGO:0001837480.011
Human
sensory organ developmentGO:0007423520.011
neuron developmentGO:00486661130.011
Fly
pancreas developmentGO:0031016190.011
regulation of bindingGO:00510981110.011
peptidyl tyrosine phosphorylationGO:00181081700.011
negative regulation of cell growthGO:0030308830.011
organophosphate biosynthetic processGO:00904071630.011
regulation of nervous system developmentGO:0051960880.011
Human
cell substrate adhesionGO:00315891320.011
mitotic cell cycle phase transitionGO:00447721620.010
neurological system processGO:00508771630.010
negative regulation of cell cycle processGO:00109481210.010
regulation of intracellular protein transportGO:00331571230.010
regulation of actin filament based processGO:00329701410.010
myeloid cell differentiationGO:00300991170.010
syncytium formation by plasma membrane fusionGO:000076820.010
metal ion homeostasisGO:00550651690.010
negative regulation of transportGO:00510511760.010
purine ribonucleoside monophosphate metabolic processGO:00091671860.010
negative regulation of proteolysisGO:00458611320.010
behaviorGO:00076101120.010
purine nucleoside monophosphate metabolic processGO:00091261860.010
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.010
mesodermal cell fate specificationGO:000750120.010
regionalizationGO:0003002290.010
forebrain generation of neuronsGO:002187230.010
positive regulation of mapk cascadeGO:00434101900.010
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.010
cell type specific apoptotic processGO:00972851250.010
Human
cellular ion homeostasisGO:00068731680.010
immune effector processGO:00022521590.010
regulation of cytoskeleton organizationGO:00514931770.010
negative regulation of sequence specific dna binding transcription factor activityGO:0043433890.010
cellular protein complex assemblyGO:00436231880.010
negative regulation of synaptic transmissionGO:005080520.010
negative regulation of immune system processGO:00026831360.010
plasma membrane organizationGO:00070091150.010
striated muscle tissue developmentGO:0014706590.010
Human
regulation of ras protein signal transductionGO:00465781550.010

NKX2-4 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.019
sensory system diseaseDOID:00501552030.019
nervous system diseaseDOID:8634310.019
disease of metabolismDOID:00146672950.018
eye diseaseDOID:56141490.016
eye and adnexa diseaseDOID:14921500.016
central nervous system diseaseDOID:3311860.015
inherited metabolic disorderDOID:6552420.013
disease of cellular proliferationDOID:145661740.011
connective tissue diseaseDOID:651090.011
cancerDOID:1621670.011
organ system cancerDOID:00506861640.011