Homo sapiens

58 known processes

POLE

polymerase (DNA directed), epsilon

(Aliases: FLJ21434,POLE1,DKFZp434F222)

POLE biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
post embryonic developmentGO:000979120.534
dna dependent dna replicationGO:0006261440.520
Yeast
dna replicationGO:00062601160.452
cellular response to dna damage stimulusGO:00069743790.360
regulation of cell cycleGO:00517263930.288
Yeast
chromatin modificationGO:00165682980.256
atp catabolic processGO:00062001570.253
dna repairGO:00062811980.201
determination of adult lifespanGO:000834020.174
peptidyl lysine modificationGO:00182051440.157
dna strand elongation involved in dna replicationGO:000627130.145
Yeast
dna biosynthetic processGO:0071897400.145
peptidyl lysine acetylationGO:00183941010.137
ribonucleotide catabolic processGO:00092614050.129
vesicle mediated transportGO:00161923710.128
ribonucleoside triphosphate catabolic processGO:00092033910.121
purine ribonucleoside triphosphate metabolic processGO:00092054110.117
multicellular organismal agingGO:001025930.116
purine ribonucleotide catabolic processGO:00091544040.113
organophosphate catabolic processGO:00464344300.106
histone exchangeGO:004348630.099
embryo developmentGO:00097901230.094
Worm
female gamete generationGO:000729220.094
cellular macromolecular complex assemblyGO:00346223240.094
response to abiotic stimulusGO:00096283360.093
chromatin organizationGO:00063253510.089
Yeast
histone acetylationGO:0016573930.086
purine ribonucleoside metabolic processGO:00461284370.086
purine ribonucleoside triphosphate catabolic processGO:00092073910.086
translesion synthesisGO:001998580.085
Yeast
mitotic cell cycle processGO:19030472860.085
dna recombinationGO:0006310770.085
Yeast
regulation of gene expression epigeneticGO:0040029730.084
Yeast
purine nucleotide catabolic processGO:00061954050.083
regulation of cell cycle processGO:00105642660.080
Yeast
negative regulation of cell cycleGO:00457861930.080
Yeast
internal peptidyl lysine acetylationGO:0018393970.078
cellular amino acid metabolic processGO:00065201160.076
purine nucleoside triphosphate catabolic processGO:00091463920.076
dna geometric changeGO:0032392320.075
ribonucleoside monophosphate metabolic processGO:00091611870.073
reproductive processGO:00224141060.070
Worm
single organism reproductive processGO:0044702980.069
Worm
nucleoside triphosphate catabolic processGO:00091433940.068
purine containing compound catabolic processGO:00725234110.067
oogenesisGO:004847720.067
response to ionizing radiationGO:0010212650.067
cell developmentGO:00484683280.067
nucleoside catabolic processGO:00091644080.066
response to radiationGO:00093141510.065
nucleus localizationGO:005164710.063
purine nucleoside catabolic processGO:00061523980.062
nuclear migrationGO:000709710.061
purine ribonucleoside catabolic processGO:00461303980.060
regulation of cell cycle phase transitionGO:19019871260.060
Yeast
negative regulation of mitotic cell cycleGO:00459301020.060
Yeast
glycosyl compound catabolic processGO:19016584130.059
chromosome segregationGO:00070591140.058
Yeast
meiotic chromosome segregationGO:004513240.058
nervous system developmentGO:00073992930.057
covalent chromatin modificationGO:00165692540.057
mitotic cell cycleGO:00002783260.057
cell cycle phase transitionGO:00447701730.056
nucleoside phosphate catabolic processGO:19012924120.055
atp metabolic processGO:00460341760.055
ribonucleoside triphosphate metabolic processGO:00091994120.053
nucleoside monophosphate catabolic processGO:00091251590.053
nucleotide catabolic processGO:00091664080.052
cellular ketone metabolic processGO:0042180800.051
establishment of nucleus localizationGO:004002310.050
ribonucleoside catabolic processGO:00424544060.047
positive regulation of cellular amino acid metabolic processGO:004576430.044
gene silencingGO:0016458490.044
Yeast
meiosis iGO:000712740.042
regulation of cellular ketone metabolic processGO:0010565500.041
histone modificationGO:00165702510.038
mitotic dna damage checkpointGO:0044773280.038
Yeast
endocytosisGO:00068971590.037
nucleotide excision repairGO:0006289310.037
microtubule based processGO:00070172100.036
internal protein amino acid acetylationGO:00064751010.035
oocyte differentiationGO:000999420.035
neurogenesisGO:00220081690.034
cellular component morphogenesisGO:00329893140.034
chromatin remodelingGO:0006338550.034
nuclear divisionGO:00002801280.034
Yeast
lagging strand elongationGO:000627330.032
regulation of mitotic cell cycle phase transitionGO:19019901180.031
Yeast
purine nucleoside monophosphate catabolic processGO:00091281580.031
regulation of cytoskeleton organizationGO:00514931770.031
response to inorganic substanceGO:00100351270.031
negative regulation of cell cycle processGO:00109481210.031
Yeast
nucleoside monophosphate metabolic processGO:00091231910.031
regulation of cellular amino acid metabolic processGO:000652160.030
protein acetylationGO:00064731160.030
response to nitrogen compoundGO:19016981840.030
protein dna complex subunit organizationGO:0071824800.030
positive regulation of cell proliferationGO:00082843010.030
endomembrane system organizationGO:00102561960.029
mitotic sister chromatid cohesionGO:0007064120.029
Yeast
double strand break repairGO:00063021010.028
Yeast
purine nucleoside triphosphate metabolic processGO:00091444120.028
regulation of cellular component biogenesisGO:00440872810.027
membrane organizationGO:00610242920.027
nucleoside triphosphate metabolic processGO:00091414220.027
multi organism reproductive processGO:0044703540.027
cell morphogenesisGO:00009022960.027
amine metabolic processGO:0009308440.026
primary mirna processingGO:003105330.026
posttranscriptional regulation of gene expressionGO:00106082130.026
protein acylationGO:00435431380.026
chromatin assembly or disassemblyGO:0006333780.025
neuron projection developmentGO:00311751060.025
regulation of cellular amine metabolic processGO:0033238110.025
regulation of multi organism processGO:00439001570.025
negative regulation of cell deathGO:00605483450.024
actin filament based processGO:00300292240.024
purine ribonucleoside monophosphate catabolic processGO:00091691580.023
negative regulation of phosphate metabolic processGO:00459362670.022
cell projection organizationGO:00300302520.022
cellular amine metabolic processGO:0044106410.021
gtp metabolic processGO:00460392390.021
protein localization to organelleGO:00333652800.021
negative regulation of apoptotic processGO:00430663160.021
negative regulation of developmental processGO:00510932470.021
cell projection morphogenesisGO:00488581290.020
histone methylationGO:0016571600.020
central nervous system developmentGO:00074171230.020
cell cycle checkpointGO:00000751170.020
Yeast
mitotic cell cycle phase transitionGO:00447721620.020
mitotic nuclear divisionGO:00070671190.020
Yeast
response to fungusGO:000962040.020
immune system developmentGO:00025201950.020
protein dna complex assemblyGO:0065004640.020
single organism cellular localizationGO:19025803320.019
chemical homeostasisGO:00488783060.019
locomotory behaviorGO:000762610.019
positive regulation of developmental processGO:00510943140.019
regulation of chromosome segregationGO:0051983440.019
rna processingGO:00063962550.019
protein alkylationGO:0008213740.019
regulation of transcription by chromatin organizationGO:003440110.019
organelle fissionGO:00482851490.019
Yeast
recombinational repairGO:0000725500.019
regulation of mitotic cell cycleGO:00073461890.019
Yeast
dna packagingGO:0006323770.019
cellular response to nitrogen compoundGO:19016991440.018
anatomical structure homeostasisGO:00602491000.018
anatomical structure formation involved in morphogenesisGO:00486462840.018
cell part morphogenesisGO:00329901370.018
regulation of protein localizationGO:00328802960.018
ion homeostasisGO:00508012300.018
positive regulation of hydrolase activityGO:00513453310.018
atp dependent chromatin remodelingGO:0043044250.017
brain developmentGO:0007420970.017
protein ubiquitinationGO:00165673140.017
dna damage checkpointGO:0000077680.017
Yeast
methylationGO:00322591060.017
epithelium developmentGO:00604292270.017
negative regulation of mitotic cell cycle phase transitionGO:1901991850.017
Yeast
establishment of protein localization to organelleGO:00725941720.017
dephosphorylationGO:00163112090.017
reproductionGO:0000003630.017
Worm
nucleosome organizationGO:0034728660.016
negative regulation of transportGO:00510511760.016
negative regulation of programmed cell deathGO:00430693210.016
positive regulation of catabolic processGO:00098963100.016
neuron differentiationGO:00301821380.016
response to organic cyclic compoundGO:00140702040.016
response to oxygen containing compoundGO:19017003690.016
positive regulation of cellular catabolic processGO:00313312840.016
intracellular protein transportGO:00068862700.016
gene silencing by mirnaGO:0035195230.016
positive regulation of cell deathGO:00109422630.016
chromatin silencingGO:0006342120.015
Yeast
protein catabolic processGO:00301633250.015
tube developmentGO:00352951250.015
head developmentGO:00603221080.015
oocyte developmentGO:004859910.015
nucleic acid phosphodiester bond hydrolysisGO:00903051020.015
Yeast
mitotic cell cycle checkpointGO:0007093680.015
Yeast
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.015
mitochondrion organizationGO:00070051560.015
positive regulation of cellular amine metabolic processGO:003324070.015
dna conformation changeGO:00711031130.015
macromolecule methylationGO:0043414970.015
mitotic sister chromatid segregationGO:0000070530.014
Yeast
regulation of microtubule cytoskeleton organizationGO:0070507610.014
mapk cascadeGO:00001652880.014
cell cycle g2 m phase transitionGO:0044839430.014
Yeast
regenerationGO:003109940.014
response to uvGO:0009411730.014
protein modification by small protein conjugationGO:00324463420.014
dna strand elongationGO:002261650.014
Yeast
regulation of chromosome organizationGO:00330441030.014
negative regulation of multicellular organismal processGO:00512413170.014
purine ribonucleoside monophosphate metabolic processGO:00091671860.014
growthGO:00400072020.014
regulation of microtubule based processGO:0032886740.014
adult locomotory behaviorGO:000834410.013
organelle assemblyGO:00709251760.013
regulation of viral genome replicationGO:0045069480.013
negative regulation of phosphorus metabolic processGO:00105632670.013
tube closureGO:006060630.013
single organism membrane organizationGO:00448022680.013
dna integrity checkpointGO:0031570710.013
Yeast
regulation of growthGO:00400081650.013
cilium assemblyGO:0042384630.013
protein importGO:00170381300.012
negative regulation of cell cycle g1 s phase transitionGO:1902807290.012
multicellular organismal reproductive processGO:0048609400.012
receptor mediated endocytosisGO:0006898840.012
positive regulation of cell cycle processGO:00900681060.012
cellular response to radiationGO:0071478650.012
neuron developmentGO:00486661130.012
alpha amino acid metabolic processGO:1901605720.012
positive regulation of purine nucleotide metabolic processGO:19005442270.012
spermatid developmentGO:000728640.012
organonitrogen compound biosynthetic processGO:19015662000.012
regulation of dna replicationGO:0006275680.012
protein oligomerizationGO:00512591730.012
non recombinational repairGO:0000726140.012
Yeast
positive regulation of nucleotide metabolic processGO:00459812300.012
cellular response to organic cyclic compoundGO:00714071270.012
microtubule organizing center organizationGO:0031023620.012
protein targeting to nucleusGO:00447441040.012
negative regulation of cellular protein metabolic processGO:00322693530.011
base excision repairGO:0006284210.011
hemopoiesisGO:00300971800.011
microtubule cytoskeleton organizationGO:00002261760.011
response to other organismGO:00517072610.011
centrosome organizationGO:0051297580.011
neuromuscular junction developmentGO:000752830.011
cell divisionGO:00513011680.011
agingGO:0007568660.011
rna interferenceGO:001624640.011
regulation of dephosphorylationGO:0035303960.011
posttranscriptional gene silencingGO:0016441250.010
cell projection assemblyGO:00300311260.010
myosin filament organizationGO:003103320.010
myosin filament assemblyGO:003103420.010
regulation of cell differentiationGO:00455953930.010
spermatid differentiationGO:004851540.010
positive regulation of programmed cell deathGO:00430682490.010
negative regulation of hydrolase activityGO:00513461820.010
negative regulation of cell cycle phase transitionGO:1901988890.010
Yeast
hematopoietic or lymphoid organ developmentGO:00485341860.010
gtp catabolic processGO:00061842370.010
positive regulation of cellular component organizationGO:00511303760.010
histone lysine methylationGO:0034968500.010
dna duplex unwindingGO:0032508300.010

POLE disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:1621670.185
disease of cellular proliferationDOID:145661740.185
organ system cancerDOID:00506861640.043
musculoskeletal system diseaseDOID:172230.039
dysostosisDOID:1934220.021
bone development diseaseDOID:0080006550.021
bone diseaseDOID:0080001880.021
connective tissue diseaseDOID:651090.021
gastrointestinal system cancerDOID:3119520.020
integumentary system diseaseDOID:16430.013
disease of metabolismDOID:00146672950.011
large intestine cancerDOID:5672290.010
intestinal cancerDOID:10155290.010
colorectal cancerDOID:9256290.010