Homo sapiens

15 known processes

ME1

malic enzyme 1, NADP(+)-dependent, cytosolic

(Aliases: HUMNDME,MES)

ME1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amino acid metabolic processGO:00065201160.235
oxidation reduction processGO:00551143960.203
small molecule biosynthetic processGO:00442831570.182
monocarboxylic acid metabolic processGO:00327871850.118
Human
carboxylic acid biosynthetic processGO:0046394970.115
lipid metabolic processGO:00066293810.115
sulfur compound metabolic processGO:00067901010.110
cellular lipid metabolic processGO:00442553030.107
amine metabolic processGO:0009308440.100
lipid biosynthetic processGO:00086101770.095
organic acid biosynthetic processGO:0016053970.091
cellular amine metabolic processGO:0044106410.090
chemical homeostasisGO:00488783060.084
response to oxidative stressGO:00069791210.084
glutathione biosynthetic processGO:000675040.083
regulation of cellular ketone metabolic processGO:0010565500.077
cellular ketone metabolic processGO:0042180800.075
post embryonic developmentGO:000979120.071
regulation of cellular amino acid metabolic processGO:000652160.063
determination of adult lifespanGO:000834020.062
regulation of cellular amine metabolic processGO:0033238110.062
multicellular organismal agingGO:001025930.060
response to oxygen containing compoundGO:19017003690.059
ion homeostasisGO:00508012300.059
fatty acid metabolic processGO:00066311150.057
positive regulation of cellular amine metabolic processGO:003324070.054
long chain fatty acid metabolic processGO:0001676300.054
organonitrogen compound biosynthetic processGO:19015662000.053
system processGO:00030083490.052
cation transportGO:00068123310.051
glutathione metabolic processGO:0006749200.049
dicarboxylic acid metabolic processGO:0043648290.048
apoptotic signaling pathwayGO:00971902680.047
single organism cellular localizationGO:19025803320.047
positive regulation of cellular amino acid metabolic processGO:004576430.047
sulfur compound biosynthetic processGO:0044272380.046
positive regulation of cellular catabolic processGO:00313312840.046
anion transportGO:00068201610.044
response to organic cyclic compoundGO:00140702040.044
nonribosomal peptide biosynthetic processGO:001918440.043
positive regulation of transportGO:00510503360.042
cellular modified amino acid metabolic processGO:0006575640.041
negative regulation of cell deathGO:00605483450.041
organic hydroxy compound metabolic processGO:19016151470.040
cytoplasmic transportGO:00164823790.039
negative regulation of apoptotic processGO:00430663160.039
transmembrane transportGO:00550853990.039
reactive oxygen species metabolic processGO:0072593750.038
organic anion transportGO:00157111030.038
vesicle mediated transportGO:00161923710.037
cellular response to oxidative stressGO:0034599850.037
negative regulation of protein metabolic processGO:00512483910.036
locomotory behaviorGO:000762610.036
purine ribonucleoside metabolic processGO:00461284370.036
response to drugGO:0042493810.035
cellular macromolecule catabolic processGO:00442653800.035
negative regulation of programmed cell deathGO:00430693210.035
single organism membrane organizationGO:00448022680.035
negative regulation of cellular protein metabolic processGO:00322693530.035
positive regulation of phosphorylationGO:00423273940.035
monocarboxylic acid biosynthetic processGO:0072330670.034
purine ribonucleoside triphosphate catabolic processGO:00092073910.034
regulation of protein localizationGO:00328802960.034
nucleoside triphosphate metabolic processGO:00091414220.034
segmentationGO:003528240.034
positive regulation of catabolic processGO:00098963100.033
negative regulation of catalytic activityGO:00430863350.033
membrane organizationGO:00610242920.033
regulation of proteolysisGO:00301622930.033
response to hormoneGO:00097251750.033
Rat
female gamete generationGO:000729220.033
extrinsic apoptotic signaling pathwayGO:00971911190.032
immune responseGO:00069553070.032
ion transmembrane transportGO:00342203380.032
cellular response to endogenous stimulusGO:00714953360.032
regulation of apoptotic signaling pathwayGO:20012331750.032
biological adhesionGO:00226103310.032
cell adhesionGO:00071553250.032
positive regulation of cellular component organizationGO:00511303760.032
cofactor metabolic processGO:0051186870.031
regulation of kinase activityGO:00435493140.031
regulation of ion homeostasisGO:2000021730.031
ras protein signal transductionGO:0007265730.031
purine containing compound catabolic processGO:00725234110.031
carbohydrate metabolic processGO:00059752070.031
response to abiotic stimulusGO:00096283360.031
oogenesisGO:004847720.031
cellular response to oxygen containing compoundGO:19017012760.031
regulation of membrane potentialGO:0042391950.031
mitochondrion organizationGO:00070051560.031
cellular homeostasisGO:00197251960.031
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.030
cell morphogenesisGO:00009022960.030
metal ion transportGO:00300012720.030
organophosphate catabolic processGO:00464344300.030
purine nucleoside triphosphate metabolic processGO:00091444120.030
positive regulation of programmed cell deathGO:00430682490.030
regulation of establishment of protein localizationGO:00702012420.030
response to lipidGO:00339932060.029
nucleoside triphosphate catabolic processGO:00091433940.029
purine nucleotide catabolic processGO:00061954050.029
glycosyl compound catabolic processGO:19016584130.029
ribonucleoside catabolic processGO:00424544060.029
ribonucleotide catabolic processGO:00092614050.029
purine ribonucleotide catabolic processGO:00091544040.029
purine ribonucleoside triphosphate metabolic processGO:00092054110.028
positive regulation of apoptotic processGO:00430652460.028
positive regulation of cell deathGO:00109422630.028
regenerationGO:003109940.028
nervous system developmentGO:00073992930.028
cellular protein catabolic processGO:00442572610.028
alpha amino acid metabolic processGO:1901605720.028
peptide metabolic processGO:0006518510.028
regulation of cell differentiationGO:00455953930.027
testosterone biosynthetic processGO:006137020.027
regulation of protein kinase activityGO:00458592890.027
purine nucleoside catabolic processGO:00061523980.027
protein catabolic processGO:00301633250.027
positive regulation of protein phosphorylationGO:00019343130.027
cellular amide metabolic processGO:0043603690.027
cellular component morphogenesisGO:00329893140.026
regulation of transferase activityGO:00513383550.026
regulation of response to external stimulusGO:00321012220.026
regulation of protein transportGO:00512232130.026
ribonucleoside triphosphate metabolic processGO:00091994120.026
protein ubiquitinationGO:00165673140.026
sulfur amino acid metabolic processGO:0000096140.026
small gtpase mediated signal transductionGO:0007264780.026
nucleoside phosphate catabolic processGO:19012924120.026
purine ribonucleoside catabolic processGO:00461303980.026
response to external biotic stimulusGO:00432072610.025
protein oligomerizationGO:00512591730.025
Mouse
regulation of cytokine productionGO:00018172320.025
regulation of cellular component biogenesisGO:00440872810.025
alcohol metabolic processGO:00060661140.025
purine nucleoside triphosphate catabolic processGO:00091463920.025
secretionGO:00469032540.024
positive regulation of hydrolase activityGO:00513453310.024
lipid transportGO:0006869900.024
nucleotide catabolic processGO:00091664080.024
maintenance of locationGO:00512351120.024
response to biotic stimulusGO:00096072760.024
negative regulation of apoptotic signaling pathwayGO:2001234970.024
modification dependent protein catabolic processGO:00199412090.024
negative regulation of phosphate metabolic processGO:00459362670.024
blastoderm segmentationGO:000735020.023
protein localization to membraneGO:00726571600.023
ribonucleoside triphosphate catabolic processGO:00092033910.023
defense responseGO:00069523150.023
epithelial cell differentiationGO:00308551410.023
actin filament based processGO:00300292240.023
protein localization to organelleGO:00333652800.023
regulation of cell cycleGO:00517263930.023
regulation of anatomical structure morphogenesisGO:00226032860.023
positive regulation of transferase activityGO:00513472270.023
glutamate metabolic processGO:0006536100.023
nucleoside catabolic processGO:00091644080.023
intracellular protein transportGO:00068862700.023
negative regulation of phosphorus metabolic processGO:00105632670.023
inorganic ion transmembrane transportGO:00986602310.023
response to inorganic substanceGO:00100351270.023
response to cytokineGO:00340972320.022
response to other organismGO:00517072610.022
lipid localizationGO:00108761060.022
neuromuscular junction developmentGO:000752830.022
limbic system developmentGO:002176130.022
cation transmembrane transportGO:00986552380.022
positive regulation of nucleotide catabolic processGO:00308131850.022
epithelium developmentGO:00604292270.022
cell projection organizationGO:00300302520.022
signal transduction by phosphorylationGO:00230142970.022
hematopoietic or lymphoid organ developmentGO:00485341860.022
cytokine productionGO:00018162470.022
single organism carbohydrate metabolic processGO:00447231930.022
cellular macromolecular complex assemblyGO:00346223240.021
response to nitrogen compoundGO:19016981840.021
regulation of ion transportGO:00432691890.021
negative regulation of cellular amine metabolic processGO:003323930.021
response to organonitrogen compoundGO:00102431560.021
ubiquitin dependent protein catabolic processGO:00065112060.021
single organism cell adhesionGO:00986021790.021
metal ion homeostasisGO:00550651690.021
positive regulation of nucleotide metabolic processGO:00459812300.021
adult locomotory behaviorGO:000834410.021
mapk cascadeGO:00001652880.021
apoptotic mitochondrial changesGO:0008637570.021
negative regulation of cellular amino acid metabolic processGO:004576320.021
positive regulation of kinase activityGO:00336742040.020
regulation of intracellular transportGO:00323861950.020
protein processingGO:00164852260.020
regulation of cellular component movementGO:00512703340.020
carboxylic acid transportGO:0046942630.020
regulation of secretion by cellGO:19035301770.020
anatomical structure formation involved in morphogenesisGO:00486462840.020
guanosine containing compound metabolic processGO:19010682440.020
regulation of secretionGO:00510461940.020
cell activationGO:00017752130.020
negative regulation of protein modification processGO:00314002000.020
regulation of homeostatic processGO:00328441210.020
glycerolipid metabolic processGO:00464861070.020
memoryGO:000761330.019
protein maturationGO:00516042330.019
regulation of cell migrationGO:00303342890.019
positive regulation of nucleoside metabolic processGO:00459791860.019
gtp metabolic processGO:00460392390.019
regulation of testosterone biosynthetic processGO:200022420.019
coenzyme metabolic processGO:0006732650.019
positive regulation of purine nucleotide metabolic processGO:19005442270.019
regulation of nucleotide catabolic processGO:00308112050.019
rho protein signal transductionGO:0007266260.019
response to reactive oxygen speciesGO:0000302610.019
cation homeostasisGO:00550801890.019
endomembrane system organizationGO:00102561960.019
protein targetingGO:00066051870.019
regulation of mapk cascadeGO:00434082620.019
secretion by cellGO:00329402260.019
nitrogen compound transportGO:00717051910.019
innate immune responseGO:00450871780.019
anterior posterior axis specificationGO:000994820.019
positive regulation of purine nucleotide catabolic processGO:00331231850.019
negative regulation of cellular component organizationGO:00511292350.019
positive regulation of synaptic transmissionGO:005080640.019
regulation of cellular response to stressGO:00801352440.018
dephosphorylationGO:00163112090.018
proteolysis involved in cellular protein catabolic processGO:00516032440.018
single organismal cell cell adhesionGO:00163371480.018
organic acid transportGO:0015849650.018
mitotic cell cycleGO:00002783260.018
guanosine containing compound catabolic processGO:19010692390.018
regulation of cell motilityGO:20001452990.018
response to extracellular stimulusGO:0009991850.018
regulation of purine nucleotide metabolic processGO:19005422640.018
response to nutrient levelsGO:0031667810.018
reactive oxygen species biosynthetic processGO:190340940.018
cellular modified amino acid biosynthetic processGO:0042398150.018
nerve developmentGO:002167540.018
negative regulation of cell proliferationGO:00082852280.018
regulation of nucleotide metabolic processGO:00061402690.018
positive regulation of protein transportGO:00512221350.018
positive regulation of immune system processGO:00026842830.018
regulation of synaptic plasticityGO:004816730.018
hemopoiesisGO:00300971800.018
negative regulation of multicellular organismal processGO:00512413170.018
positive regulation of protein kinase activityGO:00458601900.018
positive regulation of cell proliferationGO:00082843010.018
cellular response to hormone stimulusGO:00328701250.018
inorganic cation transmembrane transportGO:00986621940.018
immune system developmentGO:00025201950.018
regulation of protein serine threonine kinase activityGO:00719001790.018
circulatory system developmentGO:00723592620.018
organophosphate biosynthetic processGO:00904071630.018
lipid catabolic processGO:0016042840.018
cellular amino acid biosynthetic processGO:0008652300.018
amide biosynthetic processGO:0043604150.018
regulation of protein catabolic processGO:00421761550.017
cellular response to dna damage stimulusGO:00069743790.017
protein homooligomerizationGO:00512601000.017
cellular ion homeostasisGO:00068731680.017
negative regulation of intracellular signal transductionGO:19025321830.017
protein modification by small protein conjugationGO:00324463420.017
cell developmentGO:00484683280.017
regulation of locomotionGO:00400123290.017
peripheral nervous system developmentGO:000742220.017
hindbrain developmentGO:003090230.017
fatty acid derivative metabolic processGO:1901568350.017
morphogenesis of embryonic epitheliumGO:001633140.017
myeloid cell differentiationGO:00300991170.017
regulation of purine nucleotide catabolic processGO:00331212050.017
regulation of intracellular protein transportGO:00331571230.017
retinoic acid biosynthetic processGO:000213820.017
regulation of multi organism processGO:00439001570.017
cellular response to cytokine stimulusGO:00713451810.017
regulation of cell cycle processGO:00105642660.017
growthGO:00400072020.017
posttranscriptional regulation of gene expressionGO:00106082130.016
positive regulation of organelle organizationGO:00106381950.016
cell growthGO:00160491600.016
calcium ion homeostasisGO:00550741220.016
regulation of cytoplasmic transportGO:19036491490.016
blood circulationGO:00080151130.016
microtubule based processGO:00070172100.016
cellular lipid catabolic processGO:0044242650.016
circulatory system processGO:00030131130.016
steroid metabolic processGO:0008202940.016
negative regulation of hydrolase activityGO:00513461820.016
mitotic cell cycle processGO:19030472860.016
somitogenesisGO:000175620.016
oocyte developmentGO:004859910.016
regulation of cytoskeleton organizationGO:00514931770.016
neurological system processGO:00508771630.016
cardiac muscle cell contractionGO:008600340.016
oocyte differentiationGO:000999420.016
purine ribonucleoside monophosphate metabolic processGO:00091671860.016
glutamine family amino acid metabolic processGO:0009064170.016
positive regulation of developmental processGO:00510943140.016
regulation of nucleoside metabolic processGO:00091182090.016
response to woundingGO:00096111680.016
neurotransmitter secretionGO:000726940.016
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237520.015
associative learningGO:000830610.015
small molecule catabolic processGO:0044282920.015
regulation of cell morphogenesisGO:00226041530.015
reactive nitrogen species metabolic processGO:200105730.015
syncytium formation by plasma membrane fusionGO:000076820.015
positive regulation of proteolysisGO:00458621420.015
regulation of peptidase activityGO:00525471800.015
cardiovascular system developmentGO:00723582620.015
organic hydroxy compound biosynthetic processGO:1901617710.015
cellular protein complex assemblyGO:00436231880.015
diterpenoid biosynthetic processGO:001610220.015
regulation of growthGO:00400081650.015
endocytosisGO:00068971590.015
anterior posterior axis specification embryoGO:000859520.015
regulation of gtp catabolic processGO:00331241800.015
enzyme linked receptor protein signaling pathwayGO:00071673030.015
response to fungusGO:000962040.015
interspecies interaction between organismsGO:00444191560.015
establishment of protein localization to organelleGO:00725941720.015
spermatid differentiationGO:004851540.015
ribonucleoside monophosphate metabolic processGO:00091611870.015
vasculature developmentGO:00019441810.015
cellular metal ion homeostasisGO:00068751460.015
unsaturated fatty acid metabolic processGO:0033559370.015
tripartite regional subdivisionGO:000735120.015
response to axon injuryGO:004867810.015
regulation of transmembrane transportGO:00347621390.015
establishment of protein localization to membraneGO:00901501210.015
rhythmic behaviorGO:000762220.015
divalent inorganic cation transportGO:00725111580.015
regulation of endopeptidase activityGO:00525481700.015
negative regulation of phosphorylationGO:00423261740.015
androgen biosynthetic processGO:000670230.015
inner ear morphogenesisGO:004247240.015
regulation of reactive oxygen species metabolic processGO:2000377410.014
regulation of reactive oxygen species biosynthetic processGO:190342630.014
negative regulation of transportGO:00510511760.014
regulation of sequence specific dna binding transcription factor activityGO:00510902110.014
ameboidal type cell migrationGO:00016671350.014
sensory perception of smellGO:000760820.014
regulation of cell adhesionGO:00301551660.014
divalent metal ion transportGO:00708381520.014
motor neuron axon guidanceGO:000804520.014
symbiosis encompassing mutualism through parasitismGO:00444031560.014
regulation of ras protein signal transductionGO:00465781550.014
positive regulation of gtpase activityGO:00435471660.014
microtubule cytoskeleton organizationGO:00002261760.014
monovalent inorganic cation transportGO:00156721280.014
neurogenesisGO:00220081690.014
plasma membrane organizationGO:00070091150.014
regulation of immune responseGO:00507762010.014
purine nucleoside monophosphate metabolic processGO:00091261860.014
nucleoside monophosphate metabolic processGO:00091231910.014
blood vessel developmentGO:00015681720.014
response to metal ionGO:0010038840.014
cellular cation homeostasisGO:00300031630.014
embryonic epithelial tube formationGO:000183840.014
regulation of hormone levelsGO:00108171250.014
cell cycle phase transitionGO:00447701730.014
sequestering of metal ionGO:0051238240.013
cell type specific apoptotic processGO:00972851250.013
regulation of anatomical structure sizeGO:00900661010.013
actin cytoskeleton organizationGO:00300362070.013
negative regulation of protein phosphorylationGO:00019331400.013
response to bacteriumGO:00096171440.013
circadian behaviorGO:004851220.013
photoreceptor cell differentiationGO:004653020.013
wound healingGO:00420601150.013
modification dependent macromolecule catabolic processGO:00436322120.013
cell projection assemblyGO:00300311260.013
positive regulation of secretion by cellGO:19035321080.013
regulation of gtpase activityGO:00430871800.013
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.013
positive regulation of gtp catabolic processGO:00331261660.013
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.013
negative regulation of developmental processGO:00510932470.013
positive regulation of cytokine productionGO:00018191670.013
proteasomal protein catabolic processGO:00104981760.013
regulation of vesicle mediated transportGO:00606271300.013
spermatid developmentGO:000728640.013
g protein coupled receptor signaling pathwayGO:00071862070.013
cell part morphogenesisGO:00329901370.013
atp metabolic processGO:00460341760.013
carbohydrate derivative biosynthetic processGO:19011372070.013
response to nutrientGO:0007584200.013
central nervous system developmentGO:00074171230.013
actin mediated cell contractionGO:0070252120.013
cellular response to lipidGO:00713961270.013
regulation of metal ion transportGO:00109591200.013
cellular chemical homeostasisGO:00550821800.013
neural crest cell developmentGO:001403230.013
response to oxygen levelsGO:00704821000.013
regulation of neurotransmitter secretionGO:004692830.013
regulation of protein complex assemblyGO:00432541470.013
epidermis morphogenesisGO:004873030.013
positive regulation of ras gtpase activityGO:00323201170.013
protein localization to plasma membraneGO:0072659930.013
tissue regenerationGO:004224630.013
matingGO:000761810.013
regulation of cell growthGO:00015581350.013
calcium ion transportGO:00068161470.013
somatic muscle developmentGO:000752510.013
compound eye developmentGO:004874910.013
rna interferenceGO:001624640.013
response to steroid hormoneGO:0048545800.013
response to growth factorGO:00708482050.013
salivary gland morphogenesisGO:000743540.012
myoblast fusionGO:000752010.012
cellular response to organic cyclic compoundGO:00714071270.012
positive regulation of cell differentiationGO:00455972110.012
actin filament based movementGO:0030048170.012
purine ribonucleoside monophosphate catabolic processGO:00091691580.012
regulation of neural precursor cell proliferationGO:200017740.012
endosomal transportGO:00161971290.012
cell divisionGO:00513011680.012
spinal cord developmentGO:002151040.012
chemotaxisGO:00069351570.012
metencephalon developmentGO:002203720.012
cranial nerve developmentGO:002154540.012
divalent inorganic cation homeostasisGO:00725071360.012
regulation of defense responseGO:00313471540.012
mitotic cell cycle phase transitionGO:00447721620.012
negative regulation of transferase activityGO:00513481240.012
cellular divalent inorganic cation homeostasisGO:00725031280.012
nuclear transportGO:00511691790.012
i kappab kinase nf kappab signalingGO:00072491660.012
cellular response to external stimulusGO:00714961110.012
ribonucleoside monophosphate catabolic processGO:00091581580.012
negative regulation of protein maturationGO:19033181420.012
head developmentGO:00603221080.012
rna processingGO:00063962550.012
positive regulation of reactive oxygen species biosynthetic processGO:190342820.012
positive regulation of secretionGO:00510471160.012
regulation of meiotic cell cycleGO:005144540.012
regulation of cysteine type endopeptidase activityGO:20001161270.012
defense response to other organismGO:00985421290.012
immune effector processGO:00022521590.012
fatty acid biosynthetic processGO:0006633460.012
positive regulation of cellular component movementGO:00512721810.012
regulation of protein secretionGO:0050708860.012
multi organism cellular processGO:00447641560.012
negative regulation of cytokine productionGO:0001818820.012
cellular response to organonitrogen compoundGO:00714171240.012
gtp catabolic processGO:00061842370.012
intrinsic apoptotic signaling pathwayGO:00971931270.012
regulation of protein maturationGO:19033171500.012
positive regulation of cellular component biogenesisGO:00440891580.012
regulation of cellular protein catabolic processGO:1903362960.012
cellular calcium ion homeostasisGO:00068741170.012
generation of neuronsGO:00486991520.012
peptidyl tyrosine modificationGO:00182121700.012
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.012
cellular response to nitrogen compoundGO:19016991440.012
cell substrate adhesionGO:00315891320.012
neural tube closureGO:000184330.012
regulation of i kappab kinase nf kappab signalingGO:00431221620.011
response to radiationGO:00093141510.011
response to calcium ionGO:0051592460.011
positive regulation of cell motilityGO:20001471770.011
histone modificationGO:00165702510.011
sequestering of calcium ionGO:0051208170.011
atp catabolic processGO:00062001570.011
regulation of ion transmembrane transportGO:00347651320.011
hormone metabolic processGO:0042445610.011
leukocyte activationGO:00453211640.011
nucleocytoplasmic transportGO:00069131760.011
regulation of protein processingGO:00706131500.011
positive regulation of reactive oxygen species metabolic processGO:2000379240.011
taxisGO:00423301570.011
blood vessel morphogenesisGO:00485141620.011
regulation of small gtpase mediated signal transductionGO:00510561560.011
cellular response to glucocorticoid stimulusGO:007138540.011

ME1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
sensory system diseaseDOID:00501552030.050
nervous system diseaseDOID:8634310.050
Human
disease of metabolismDOID:00146672950.044
inherited metabolic disorderDOID:6552420.032
musculoskeletal system diseaseDOID:172230.030
eye and adnexa diseaseDOID:14921500.030
eye diseaseDOID:56141490.030
central nervous system diseaseDOID:3311860.026
Human
retinal diseaseDOID:56791180.024
disease of cellular proliferationDOID:145661740.023
cancerDOID:1621670.023
organ system cancerDOID:00506861640.019
retinal degenerationDOID:8466890.018
muscular diseaseDOID:00800001140.015
muscle tissue diseaseDOID:661130.015
connective tissue diseaseDOID:651090.014
myopathyDOID:4231040.014
bone diseaseDOID:0080001880.014
cardiovascular system diseaseDOID:12871060.013
brain diseaseDOID:936730.013
Human
neurodegenerative diseaseDOID:12891020.013
immune system diseaseDOID:29141550.013