Homo sapiens

38 known processes

HFE

hemochromatosis

(Aliases: HLA-H,HFE1,dJ221C16.10.1,HH,MVCD7,MGC103790)

HFE biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cation transportGO:00068123310.246
detection of chemical stimulus involved in sensory perceptionGO:0050907330.222
Human
transition metal ion transportGO:0000041230.197
immune response inhibiting cell surface receptor signaling pathwayGO:000276740.175
Human
regulation of cytokine productionGO:00018172320.096
Human
ion homeostasisGO:00508012300.088
Mouse Rat
iron ion homeostasisGO:0055072150.080
Mouse Rat
t cell differentiation in thymusGO:003307740.074
response to other organismGO:00517072610.072
Human
chemical homeostasisGO:00488783060.071
Mouse Rat
detection of chemical stimulusGO:0009593550.070
Human
protein refoldingGO:0042026140.069
regulation of regulatory t cell differentiationGO:004558940.065
Human
hemopoiesisGO:00300971800.062
Human
response to biotic stimulusGO:00096072760.061
Human
negative regulation of cell differentiationGO:00455961710.059
Human
multicellular organismal homeostasisGO:0048871670.059
Human Mouse
response to external biotic stimulusGO:00432072610.057
Human
positive regulation of immune system processGO:00026842830.048
Human
post embryonic developmentGO:000979120.048
innate immune responseGO:00450871780.045
Human
anatomical structure homeostasisGO:00602491000.045
Human
cation homeostasisGO:00550801890.044
Mouse Rat
regulation of transferase activityGO:00513383550.044
positive regulation of developmental processGO:00510943140.043
Human
immune responseGO:00069553070.042
Human
glycosyl compound catabolic processGO:19016584130.042
defense responseGO:00069523150.042
Human Rat
lipid metabolic processGO:00066293810.041
ribonucleotide catabolic processGO:00092614050.040
purine nucleoside catabolic processGO:00061523980.040
purine ribonucleoside catabolic processGO:00461303980.039
leukocyte differentiationGO:0002521980.039
Human
positive regulation of hydrolase activityGO:00513453310.039
positive regulation of cellular component organizationGO:00511303760.039
metal ion homeostasisGO:00550651690.039
Mouse Rat
organophosphate catabolic processGO:00464344300.039
positive regulation of innate immune responseGO:0045089790.038
Human
response to metal ionGO:0010038840.037
regulation of cell differentiationGO:00455953930.037
Human
carbohydrate metabolic processGO:00059752070.037
immune system developmentGO:00025201950.036
Human
signal transduction by phosphorylationGO:00230142970.036
purine ribonucleoside metabolic processGO:00461284370.036
hematopoietic or lymphoid organ developmentGO:00485341860.036
Human
ribonucleoside triphosphate metabolic processGO:00091994120.036
cellular lipid metabolic processGO:00442553030.036
immune response regulating signaling pathwayGO:0002764970.036
Human
retina homeostasisGO:0001895420.036
Human
purine containing compound catabolic processGO:00725234110.036
detection of chemical stimulus involved in sensory perception of tasteGO:0050912310.035
Human
biological adhesionGO:00226103310.035
Human
regulation of mapk cascadeGO:00434082620.035
positive regulation of phosphorylationGO:00423273940.034
nucleoside phosphate catabolic processGO:19012924120.034
tissue homeostasisGO:0001894630.033
Human
purine nucleoside triphosphate catabolic processGO:00091463920.033
detection of external biotic stimulusGO:0098581190.033
Human
positive regulation of immune responseGO:00507781590.033
Human
regulation of natural killer cell mediated cytotoxicityGO:0042269160.032
Human
oxidation reduction processGO:00551143960.032
cellular amino acid metabolic processGO:00065201160.031
ribonucleoside triphosphate catabolic processGO:00092033910.031
cytokine productionGO:00018162470.031
Human
regulation of innate immune responseGO:0045088970.030
Human
positive regulation of cell differentiationGO:00455972110.030
Human
nucleoside catabolic processGO:00091644080.030
cellular cation homeostasisGO:00300031630.030
regulation of leukocyte differentiationGO:1902105610.030
Human
positive regulation of mapk cascadeGO:00434101900.029
response to inorganic substanceGO:00100351270.029
negative regulation of cellular component organizationGO:00511292350.029
purine ribonucleoside triphosphate metabolic processGO:00092054110.028
nucleoside triphosphate metabolic processGO:00091414220.028
amine metabolic processGO:0009308440.027
positive regulation of kinase activityGO:00336742040.027
neurological system processGO:00508771630.027
Human
cellular ion homeostasisGO:00068731680.027
mapk cascadeGO:00001652880.026
regulation of protein transportGO:00512232130.026
regulation of immune responseGO:00507762010.026
Human
regulation of defense responseGO:00313471540.026
Human
cellular homeostasisGO:00197251960.026
regulation of establishment of protein localizationGO:00702012420.026
protein processingGO:00164852260.026
positive regulation of protein phosphorylationGO:00019343130.026
positive regulation of protein kinase activityGO:00458601900.026
cell adhesionGO:00071553250.026
Human
regulation of protein localizationGO:00328802960.025
system processGO:00030083490.025
Human
sensory perception of chemical stimulusGO:0007606380.025
Human
positive regulation of cytokine productionGO:00018191670.024
Human
cytoplasmic transportGO:00164823790.024
cell projection organizationGO:00300302520.024
detection of stimulusGO:0051606850.024
Human
positive regulation of cellular amine metabolic processGO:003324070.024
ribonucleoside catabolic processGO:00424544060.024
regulation of secretion by cellGO:19035301770.024
enzyme linked receptor protein signaling pathwayGO:00071673030.023
purine nucleotide catabolic processGO:00061954050.023
regulation of cellular ketone metabolic processGO:0010565500.023
hemoglobin biosynthetic processGO:004254130.023
single organism carbohydrate metabolic processGO:00447231930.023
regulation of cellular response to stressGO:00801352440.023
intracellular protein transportGO:00068862700.023
lipid biosynthetic processGO:00086101770.023
purine ribonucleoside triphosphate catabolic processGO:00092073910.022
regulation of cellular amine metabolic processGO:0033238110.022
rho protein signal transductionGO:0007266260.022
regulation of cellular amino acid metabolic processGO:000652160.022
regulation of protein kinase activityGO:00458592890.022
cellular amine metabolic processGO:0044106410.022
actin filament based processGO:00300292240.022
nitrogen compound transportGO:00717051910.022
locomotory behaviorGO:000762610.022
negative regulation of leukocyte differentiationGO:1902106240.022
Human
positive regulation of transportGO:00510503360.022
response to organic cyclic compoundGO:00140702040.021
female gamete generationGO:000729220.021
neuromuscular junction developmentGO:000752830.021
purine nucleoside triphosphate metabolic processGO:00091444120.021
cellular ketone metabolic processGO:0042180800.021
negative regulation of cellular protein metabolic processGO:00322693530.021
purine ribonucleotide catabolic processGO:00091544040.021
regulation of protein serine threonine kinase activityGO:00719001790.021
negative regulation of cell proliferationGO:00082852280.021
Human
cellular chemical homeostasisGO:00550821800.021
immune effector processGO:00022521590.020
Human
antigen processing and presentation via mhc class ibGO:000247530.020
Human
positive regulation of map kinase activityGO:0043406800.020
leukocyte activationGO:00453211640.020
Human
protein foldingGO:0006457380.020
lymphocyte activationGO:00466491330.020
Human
secretionGO:00469032540.020
positive regulation of t cell tolerance inductionGO:000266620.020
Human
regulation of homeostatic processGO:00328441210.020
regulation of cell cycle processGO:00105642660.019
positive regulation of catabolic processGO:00098963100.019
mitotic cell cycle processGO:19030472860.019
regulation of kinase activityGO:00435493140.019
detection of biotic stimulusGO:0009595210.019
Human
negative regulation of apoptotic processGO:00430663160.019
negative regulation of phosphate metabolic processGO:00459362670.019
protein maturationGO:00516042330.018
apoptotic signaling pathwayGO:00971902680.018
regulation of anatomical structure morphogenesisGO:00226032860.018
vesicle mediated transportGO:00161923710.018
nucleotide catabolic processGO:00091664080.018
response to bacteriumGO:00096171440.018
Human
cellular metal ion homeostasisGO:00068751460.018
cellular macromolecular complex assemblyGO:00346223240.018
myeloid leukocyte differentiationGO:0002573600.018
transmembrane transportGO:00550853990.018
symbiosis encompassing mutualism through parasitismGO:00444031560.018
negative regulation of interleukin 5 productionGO:003271430.018
positive regulation of apoptotic processGO:00430652460.018
organic anion transportGO:00157111030.017
cellular component morphogenesisGO:00329893140.017
regulation of interleukin 12 productionGO:0032655150.017
Human
regulation of cell cycleGO:00517263930.017
regulation of purine nucleotide metabolic processGO:19005422640.017
multi organism cellular processGO:00447641560.017
negative regulation of protein metabolic processGO:00512483910.017
positive regulation of cellular amino acid metabolic processGO:004576430.017
mitotic cell cycleGO:00002783260.017
secretion by cellGO:00329402260.017
guanosine containing compound catabolic processGO:19010692390.017
zymogen activationGO:0031638700.017
cellular response to dna damage stimulusGO:00069743790.017
response to drugGO:0042493810.017
spermatid differentiationGO:004851540.017
adaptive immune responseGO:0002250490.017
Human
oogenesisGO:004847720.017
positive regulation of regulatory t cell differentiationGO:004559130.017
Human
cell morphogenesisGO:00009022960.017
determination of adult lifespanGO:000834020.017
blastoderm segmentationGO:000735020.017
regulation of cell growthGO:00015581350.016
proteolysis involved in cellular protein catabolic processGO:00516032440.016
protein catabolic processGO:00301633250.016
response to cytokineGO:00340972320.016
multicellular organismal signalingGO:0035637340.016
angiogenesisGO:00015251470.016
ribonucleoside monophosphate metabolic processGO:00091611870.016
regulation of leukocyte activationGO:00026941150.016
Human
negative regulation of intracellular signal transductionGO:19025321830.016
ribonucleoside monophosphate catabolic processGO:00091581580.016
negative regulation of catalytic activityGO:00430863350.016
positive regulation of protein serine threonine kinase activityGO:00719021190.016
small gtpase mediated signal transductionGO:0007264780.016
erk1 and erk2 cascadeGO:00703711040.016
nucleoside triphosphate catabolic processGO:00091433940.016
histone modificationGO:00165702510.016
regulation of neural precursor cell proliferationGO:200017740.016
cell activationGO:00017752130.016
Human
positive regulation of nucleoside metabolic processGO:00459791860.016
lymphocyte mediated immunityGO:0002449480.016
Human
sulfur compound metabolic processGO:00067901010.016
sensory perception of tasteGO:0050909360.016
Human
dephosphorylationGO:00163112090.016
cell growthGO:00160491600.016
cation transmembrane transportGO:00986552380.016
myeloid cell differentiationGO:00300991170.016
regulation of map kinase activityGO:00434051080.015
negative regulation of cellular amino acid metabolic processGO:004576320.015
positive regulation of neural precursor cell proliferationGO:200017920.015
regulation of locomotionGO:00400123290.015
regulation of nucleoside metabolic processGO:00091182090.015
purine nucleoside monophosphate metabolic processGO:00091261860.015
regulation of purine nucleotide catabolic processGO:00331212050.015
maintenance of locationGO:00512351120.015
regulation of secretionGO:00510461940.015
negative regulation of phosphorus metabolic processGO:00105632670.015
compound eye developmentGO:004874910.015
adult locomotory behaviorGO:000834410.015
dna repairGO:00062811980.015
circulatory system developmentGO:00723592620.015
positive regulation of transferase activityGO:00513472270.015
cell cycle phase transitionGO:00447701730.015
positive regulation of locomotionGO:00400171860.015
monocarboxylic acid metabolic processGO:00327871850.015
negative regulation of organelle organizationGO:00106391260.015
segmentationGO:003528240.015
defense response to other organismGO:00985421290.015
single organism cellular localizationGO:19025803320.015
response to abiotic stimulusGO:00096283360.015
regulation of immune effector processGO:0002697910.015
Human
actin mediated cell contractionGO:0070252120.015
lipid catabolic processGO:0016042840.015
negative regulation of transportGO:00510511760.014
positive regulation of protein transportGO:00512221350.014
regulation of intracellular transportGO:00323861950.014
alcohol metabolic processGO:00060661140.014
ras protein signal transductionGO:0007265730.014
cell developmentGO:00484683280.014
natural killer cell mediated immunityGO:0002228230.014
Human
positive regulation of leukocyte differentiationGO:1902107370.014
Human
syncytium formation by plasma membrane fusionGO:000076820.014
regulation of proteolysisGO:00301622930.014
positive regulation of cellular catabolic processGO:00313312840.014
hemoglobin metabolic processGO:002002730.014
neuronal action potentialGO:001922890.014
glycoprotein metabolic processGO:00091001100.014
regulation of protein secretionGO:0050708860.014
regulation of cell adhesionGO:00301551660.014
chromatin organizationGO:00063253510.014
monosaccharide metabolic processGO:0005996740.014
chromatin modificationGO:00165682980.014
leukocyte mediated cytotoxicityGO:0001909270.014
Human
immune response inhibiting signal transductionGO:000276540.014
Human
positive regulation of cellular component movementGO:00512721810.014
oocyte developmentGO:004859910.014
positive regulation of programmed cell deathGO:00430682490.013
negative regulation of cellular amine metabolic processGO:003323930.013
spermatid developmentGO:000728640.013
positive regulation of natural killer cell mediated immunityGO:0002717120.013
Human
atp catabolic processGO:00062001570.013
regulation of stress activated mapk cascadeGO:0032872840.013
response to fungusGO:000962040.013
peripheral nervous system developmentGO:000742220.013
small molecule biosynthetic processGO:00442831570.013
nucleoside monophosphate catabolic processGO:00091251590.013
positive regulation of purine nucleotide catabolic processGO:00331231850.013
purine nucleoside monophosphate catabolic processGO:00091281580.013
memoryGO:000761330.013
positive regulation of nucleotide catabolic processGO:00308131850.013
cellular protein catabolic processGO:00442572610.013
negative regulation of acetylcholine gated cation channel activityGO:190304910.013
calcium ion transportGO:00068161470.013
multicellular organismal agingGO:001025930.013
purine ribonucleoside monophosphate metabolic processGO:00091671860.013
glycoprotein biosynthetic processGO:0009101910.013
regulation of mitotic cell cycleGO:00073461890.013
mitotic cell cycle phase transitionGO:00447721620.013
positive regulation of secretionGO:00510471160.013
nervous system developmentGO:00073992930.013
negative regulation of transferase activityGO:00513481240.013
regulation of cell activationGO:00508651250.013
Human
cellular macromolecule catabolic processGO:00442653800.013
visual behaviorGO:000763220.013
positive regulation of lymphocyte mediated immunityGO:0002708230.013
Human
stress activated mapk cascadeGO:0051403930.013
positive regulation of cell proliferationGO:00082843010.013
morphogenesis of embryonic epitheliumGO:001633140.013
metal ion transportGO:00300012720.013
blood vessel developmentGO:00015681720.013
regulation of cytoskeleton organizationGO:00514931770.013
single organism membrane organizationGO:00448022680.013
action potentialGO:0001508340.012
negative regulation of cell cycle processGO:00109481210.012
stress activated protein kinase signaling cascadeGO:0031098940.012
positive regulation of leukocyte activationGO:0002696800.012
Human
rhythmic behaviorGO:000762220.012
t cell tolerance inductionGO:000251740.012
Human
regulation of protein maturationGO:19033171500.012
t cell mediated immunityGO:0002456250.012
Human
positive regulation of purine nucleotide metabolic processGO:19005442270.012
regulation of leukocyte proliferationGO:0070663670.012
Human
regulation of cell killingGO:0031341220.012
Human
cell substrate adhesionGO:00315891320.012
positive regulation of gtp catabolic processGO:00331261660.012
regulation of cell substrate adhesionGO:0010810680.012
regulation of gtpase activityGO:00430871800.012
regulation of nucleotide metabolic processGO:00061402690.012
regulation of gtp catabolic processGO:00331241800.012
positive regulation of leukocyte mediated immunityGO:0002705240.012
Human
response to oxygen containing compoundGO:19017003690.012
immune response activating signal transductionGO:0002757900.012
natural killer cell mediated cytotoxicityGO:0042267230.012
Human
endocytosisGO:00068971590.012
covalent chromatin modificationGO:00165692540.012
negative regulation of t helper 2 cell cytokine productionGO:200055220.012
regulation of cytokine secretionGO:0050707570.012
regulation of nucleotide catabolic processGO:00308112050.012
gtp catabolic processGO:00061842370.012
cellular response to oxygen containing compoundGO:19017012760.012
circadian behaviorGO:004851220.012
mononuclear cell proliferationGO:0032943710.012
Human
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.012
negative regulation of programmed cell deathGO:00430693210.012
regulation of multi organism processGO:00439001570.012
negative regulation of cell cycleGO:00457861930.012
regulation of t cell activationGO:0050863770.012
Human
protein oligomerizationGO:00512591730.012
cardiac muscle cell contractionGO:008600340.012
antigen processing and presentation of exogenous peptide antigenGO:000247840.012
gtp metabolic processGO:00460392390.012
establishment of protein localization to organelleGO:00725941720.012
postsynaptic membrane organizationGO:000194120.012
interaction with hostGO:0051701420.011
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822290.011
Human
positive regulation of organelle organizationGO:00106381950.011
protein homooligomerizationGO:00512601000.011
embryonic hemopoiesisGO:003516240.011
regulation of cell cycle phase transitionGO:19019871260.011
leukocyte mediated immunityGO:0002443590.011
Human
positive regulation of cell deathGO:00109422630.011
regulation of vesicle mediated transportGO:00606271300.011
cellular response to cytokine stimulusGO:00713451810.011
regulation of leukocyte mediated immunityGO:0002703380.011
Human
protein modification by small protein removalGO:0070646920.011
regulation of i kappab kinase nf kappab signalingGO:00431221620.011
regulation of myelinationGO:003164110.011
regulation of dna metabolic processGO:00510521530.011
atp metabolic processGO:00460341760.011
monovalent inorganic cation transportGO:00156721280.011
associative learningGO:000830610.011
posttranscriptional regulation of gene expressionGO:00106082130.011
positive regulation of nucleotide metabolic processGO:00459812300.011
regulation of protein catabolic processGO:00421761550.011
neurogenesisGO:00220081690.011
lymphocyte proliferationGO:0046651700.011
Human
purine ribonucleoside monophosphate catabolic processGO:00091691580.011
actin cytoskeleton organizationGO:00300362070.011
guanosine containing compound metabolic processGO:19010682440.011
protein localization to organelleGO:00333652800.011
t cell activationGO:0042110990.011
Human
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.011
regulation of cell projection organizationGO:00313441070.011
mitochondrion organizationGO:00070051560.011
oocyte differentiationGO:000999420.011
protein importGO:00170381300.011
axis elongationGO:000340140.011
nucleocytoplasmic transportGO:00069131760.011
activation of immune responseGO:00022531140.011
endosomal transportGO:00161971290.011
cell divisionGO:00513011680.011
regulation of apoptotic signaling pathwayGO:20012331750.011
positive regulation of proteolysisGO:00458621420.011
positive regulation of peptidase activityGO:0010952880.011
response to nitrogen compoundGO:19016981840.011
negative regulation of leukocyte mediated immunityGO:0002704140.011
Human
regulation of erk1 and erk2 cascadeGO:0070372990.010
regulation of growthGO:00400081650.010
response to molecule of bacterial originGO:0002237820.010
regulation of bone resorptionGO:004512440.010
positive regulation of gliogenesisGO:001401540.010
cell killingGO:0001906340.010
Human
positive regulation of stress activated protein kinase signaling cascadeGO:0070304610.010
antigen processing and presentation of exogenous antigenGO:001988440.010
cellular response to hormone stimulusGO:00328701250.010
calcium ion homeostasisGO:00550741220.010
defense response to bacteriumGO:0042742630.010
regulation of cell divisionGO:00513021160.010
modification dependent protein catabolic processGO:00199412090.010
detection of other organismGO:0098543130.010
Human
response to axon injuryGO:004867810.010
protein secretionGO:0009306980.010
divalent inorganic cation homeostasisGO:00725071360.010
protein targetingGO:00066051870.010
mitotic nuclear divisionGO:00070671190.010
stem cell divisionGO:001714520.010
regulation of actin cytoskeleton organizationGO:00329561160.010
nuclear transportGO:00511691790.010
negative regulation of hydrolase activityGO:00513461820.010
anatomical structure formation involved in morphogenesisGO:00486462840.010
meiosis iGO:000712740.010

HFE disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.208
inherited metabolic disorderDOID:6552420.102
musculoskeletal system diseaseDOID:172230.030
bone diseaseDOID:0080001880.021
connective tissue diseaseDOID:651090.021
sensory system diseaseDOID:00501552030.020
nervous system diseaseDOID:8634310.020
central nervous system diseaseDOID:3311860.020
cancerDOID:1621670.019
disease of cellular proliferationDOID:145661740.019
organ system cancerDOID:00506861640.019
eye diseaseDOID:56141490.016
eye and adnexa diseaseDOID:14921500.016
disease of mental healthDOID:150700.012
retinal diseaseDOID:56791180.012
cardiovascular system diseaseDOID:12871060.012
neurodegenerative diseaseDOID:12891020.010
integumentary system diseaseDOID:16430.004
skin diseaseDOID:37330.004
cognitive disorderDOID:1561290.002
tauopathyDOID:680160.002
dementiaDOID:1307190.002
alzheimer s diseaseDOID:10652160.001
acute porphyriaDOID:313370.001
porphyriaDOID:1326880.001
metal metabolism disorderDOID:896190.001
hemochromatosisDOID:235260.001