Homo sapiens

104 known processes

TBK1

TANK-binding kinase 1

(Aliases: NAK,T2K,FLJ11330)

TBK1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of interferon beta productionGO:0032728170.997
positive regulation of interferon alpha productionGO:0032727110.845
determination of adult lifespanGO:000834020.831
endosomal transportGO:00161971290.815
Fly
serine phosphorylation of stat proteinGO:004250140.758
Human
type i interferon productionGO:0032606270.748
regulation of interferon beta biosynthetic processGO:004535740.698
Mouse
response to cytokineGO:00340972320.663
Human
regulation of cell cycleGO:00517263930.654
positive regulation of cytokine productionGO:00018191670.628
response to other organismGO:00517072610.596
Mouse
protein k63 linked deubiquitinationGO:0070536210.583
regulation of interferon alpha productionGO:0032647110.558
interferon alpha productionGO:0032607110.557
programmed necrotic cell deathGO:0097300180.539
endocytic recyclingGO:0032456120.530
Fly
vesicle mediated transportGO:00161923710.502
Fly
regulation of i kappab kinase nf kappab signalingGO:00431221620.488
regulation of cytokine productionGO:00018172320.469
positive regulation of cytokine mediated signaling pathwayGO:0001961120.446
protein polyubiquitinationGO:00002091100.445
cellular response to external stimulusGO:00714961110.383
intracellular protein transportGO:00068862700.378
regulation of response to external stimulusGO:00321012220.352
cellular response to dna damage stimulusGO:00069743790.345
Human
golgi organizationGO:0007030380.344
positive regulation of immune responseGO:00507781590.337
Mouse
microtubule cytoskeleton organizationGO:00002261760.333
Fly
i kappab kinase nf kappab signalingGO:00072491660.314
somitogenesisGO:000175620.294
golgi ribbon formationGO:009016130.292
mitotic cell cycleGO:00002783260.284
regulation of type i interferon productionGO:0032479260.280
cell developmentGO:00484683280.280
Fly
cell activationGO:00017752130.275
Mouse
modification dependent macromolecule catabolic processGO:00436322120.266
immune responseGO:00069553070.264
Mouse
regulation of interferon beta productionGO:0032648220.264
positive regulation of peptidase activityGO:0010952880.256
Fly
defense response to bacteriumGO:0042742630.253
Mouse
negative regulation of apoptotic processGO:00430663160.245
epithelium developmentGO:00604292270.241
chemical homeostasisGO:00488783060.233
i kappab phosphorylationGO:000725270.220
protein localization to organelleGO:00333652800.218
nik nf kappab signalingGO:0038061120.211
Human
regulation of cysteine type endopeptidase activityGO:20001161270.202
Fly
protein targetingGO:00066051870.200
response to bacteriumGO:00096171440.199
Mouse
multicellular organismal agingGO:001025930.196
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.196
Fly
positive regulation of transportGO:00510503360.195
peptidyl serine phosphorylationGO:00181051010.194
Human Fly
interferon beta productionGO:0032608230.189
regulation of proteolysisGO:00301622930.174
Fly
lipid homeostasisGO:0055088390.170
regulation of sequence specific dna binding transcription factor activityGO:00510902110.169
Human
apoptotic signaling pathwayGO:00971902680.167
Human
positive regulation of defense responseGO:0031349870.165
Mouse
neurotransmitter secretionGO:000726940.162
establishment of protein localization to organelleGO:00725941720.153
locomotory behaviorGO:000762610.145
post embryonic developmentGO:000979120.135
cellular component morphogenesisGO:00329893140.133
Fly
regulation of secretionGO:00510461940.133
necrotic cell deathGO:0070265210.130
regulation of mitotic cell cycleGO:00073461890.130
transmembrane transportGO:00550853990.129
positive regulation of cell deathGO:00109422630.128
Fly
extrinsic apoptotic signaling pathwayGO:00971911190.128
cation transportGO:00068123310.124
segmentationGO:003528240.124
interferon beta biosynthetic processGO:004535040.123
Mouse
innate immune responseGO:00450871780.123
Mouse
response to external biotic stimulusGO:00432072610.122
Mouse
cellular response to cytokine stimulusGO:00713451810.117
Human
positive regulation of cysteine type endopeptidase activityGO:2001056790.117
Fly
detection of stimulus involved in sensory perceptionGO:0050906430.114
regulation of vesicle mediated transportGO:00606271300.110
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.107
Fly
actin filament based processGO:00300292240.106
Fly
cytokine productionGO:00018162470.105
protein foldingGO:0006457380.100
leukocyte differentiationGO:0002521980.092
mitochondrion organizationGO:00070051560.090
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.089
jak stat cascadeGO:0007259460.088
negative regulation of cytokine productionGO:0001818820.086
protein maturationGO:00516042330.085
negative regulation of developmental processGO:00510932470.085
negative regulation of cell deathGO:00605483450.083
positive regulation of secretionGO:00510471160.082
ribonucleoprotein complex subunit organizationGO:0071826810.080
biological adhesionGO:00226103310.080
protein deubiquitinationGO:0016579790.080
single organism cellular localizationGO:19025803320.080
cellular response to oxygen containing compoundGO:19017012760.078
adaptive immune responseGO:0002250490.077
regulation of establishment of protein localizationGO:00702012420.076
response to virusGO:00096151260.076
cytoplasmic transportGO:00164823790.076
negative regulation of cell cycleGO:00457861930.073
protein autophosphorylationGO:00467771230.072
Fly
hemopoiesisGO:00300971800.071
negative regulation of protein metabolic processGO:00512483910.069
calcium ion transportGO:00068161470.068
regulation of intracellular transportGO:00323861950.067
anatomical structure formation involved in morphogenesisGO:00486462840.066
regulation of immune effector processGO:0002697910.065
cellular macromolecular complex assemblyGO:00346223240.065
nuclear transportGO:00511691790.064
regulation of neuroblast proliferationGO:190269230.064
positive regulation of type i interferon productionGO:0032481200.061
behaviorGO:00076101120.061
response to nitrogen compoundGO:19016981840.060
positive regulation of phosphorylationGO:00423273940.060
ion transmembrane transportGO:00342203380.060
negative regulation of cell differentiationGO:00455961710.060
response to lipidGO:00339932060.059
positive regulation of hydrolase activityGO:00513453310.059
Fly
circadian sleep wake cycleGO:004274520.058
cellular response to nutrient levelsGO:0031669690.058
response to oxidative stressGO:00069791210.058
positive regulation of programmed cell deathGO:00430682490.058
Fly
stress activated protein kinase signaling cascadeGO:0031098940.057
cellular macromolecule catabolic processGO:00442653800.056
negative regulation of cell cycle phase transitionGO:1901988890.054
protein importGO:00170381300.054
regulation of innate immune responseGO:0045088970.053
Mouse
divalent metal ion transportGO:00708381520.052
cell type specific apoptotic processGO:00972851250.052
negative regulation of immune system processGO:00026831360.052
detection of stimulusGO:0051606850.051
negative regulation of multicellular organismal processGO:00512413170.050
mrna metabolic processGO:00160711750.049
rna interferenceGO:001624640.048
negative regulation of cellular component organizationGO:00511292350.048
regulation of cellular response to stressGO:00801352440.047
mapk cascadeGO:00001652880.047
rna 3 end processingGO:0031123350.047
regulation of mapk cascadeGO:00434082620.046
matingGO:000761810.046
response to oxygen containing compoundGO:19017003690.045
regulation of cytoskeleton organizationGO:00514931770.045
Fly
secretion by cellGO:00329402260.045
metal ion transportGO:00300012720.045
proteolysis involved in cellular protein catabolic processGO:00516032440.045
regulation of cytoplasmic transportGO:19036491490.044
circadian behaviorGO:004851220.044
positive regulation of apoptotic processGO:00430652460.044
Fly
wound healingGO:00420601150.044
regulation of mitotic cell cycle phase transitionGO:19019901180.043
neuroblast proliferationGO:000740540.043
positive regulation of neuroblast proliferationGO:000205220.043
purine ribonucleoside triphosphate catabolic processGO:00092073910.042
regulation of protein transportGO:00512232130.042
regulation of synaptic plasticityGO:004816730.041
positive regulation of immune system processGO:00026842830.040
Mouse
positive regulation of defense response to virus by hostGO:0002230140.040
receptor metabolic processGO:0043112810.040
defense responseGO:00069523150.039
Mouse
covalent chromatin modificationGO:00165692540.039
protein targeting to nucleusGO:00447441040.039
ribonucleoprotein complex assemblyGO:0022618780.039
endomembrane system organizationGO:00102561960.039
protein catabolic processGO:00301633250.039
regulation of response to woundingGO:19030341010.038
positive regulation of response to cytokine stimulusGO:0060760130.038
spermatid differentiationGO:004851540.038
cellular protein catabolic processGO:00442572610.038
sensory organ developmentGO:0007423520.038
Fly
negative regulation of programmed cell deathGO:00430693210.037
neuron differentiationGO:00301821380.037
Fly
cellular homeostasisGO:00197251960.037
neuron remodelingGO:001632220.036
Fly
morphogenesis of embryonic epitheliumGO:001633140.036
actin filament bundle organizationGO:0061572540.035
Fly
neurological system processGO:00508771630.034
regulation of adaptive immune responseGO:0002819330.034
nucleoside catabolic processGO:00091644080.034
negative regulation of nf kappab transcription factor activityGO:0032088510.034
response to type i interferonGO:0034340140.033
embryonic heart tube morphogenesisGO:000314380.033
axoneme assemblyGO:003508230.033
cell cycle phase transitionGO:00447701730.033
intrinsic apoptotic signaling pathwayGO:00971931270.033
Human
regulation of type i interferon mediated signaling pathwayGO:006033890.033
chromatin organizationGO:00063253510.033
negative regulation of interferon beta productionGO:003268840.033
positive regulation of proteolysisGO:00458621420.032
Fly
peptide transportGO:0015833740.032
histone modificationGO:00165702510.031
regulation of jak stat cascadeGO:0046425440.031
Human
regulation of cellular component biogenesisGO:00440872810.031
protein transmembrane transportGO:0071806250.031
circadian sleep wake cycle sleepGO:005080220.031
positive regulation of exocytosisGO:0045921350.031
signal releaseGO:0023061700.031
regulation of nucleocytoplasmic transportGO:0046822980.031
establishment of protein localization to mitochondrionGO:0072655220.031
positive regulation of secretion by cellGO:19035321080.031
positive regulation of intracellular transportGO:00323881040.030
innate immune response activating signal transductionGO:0002758480.030
positive regulation of nf kappab transcription factor activityGO:0051092810.030
Human
regulation of leukocyte differentiationGO:1902105610.030
response to woundingGO:00096111680.030
retrograde transport endosome to golgiGO:0042147450.029
centrosome duplicationGO:0051298280.029
translationGO:00064121320.029
protein processingGO:00164852260.029
divalent inorganic cation transportGO:00725111580.029
cellular chemical homeostasisGO:00550821800.029
positive regulation of protein phosphorylationGO:00019343130.029
microtubule organizing center organizationGO:0031023620.028
associative learningGO:000830610.028
regulation of cell differentiationGO:00455953930.028
negative regulation of cysteine type endopeptidase activityGO:2000117480.028
response to tumor necrosis factorGO:0034612760.027
Human
leukocyte mediated immunityGO:0002443590.027
lymphocyte mediated immunityGO:0002449480.027
cilium organizationGO:0044782680.027
positive regulation of innate immune responseGO:0045089790.027
Mouse
regulation of peptidase activityGO:00525471800.027
Fly
long term memoryGO:000761620.026
agingGO:0007568660.026
regulation of synapse structural plasticityGO:005182320.026
response to mechanical stimulusGO:0009612510.026
protein localization to endoplasmic reticulumGO:0070972190.026
regionalizationGO:0003002290.026
cell adhesionGO:00071553250.026
meiotic chromosome segregationGO:004513240.026
cellular response to extracellular stimulusGO:0031668720.026
regulation of embryonic developmentGO:0045995200.026
atp metabolic processGO:00460341760.026
protein import into nucleusGO:00066061040.025
activation of immune responseGO:00022531140.025
Mouse
cellular response to organic cyclic compoundGO:00714071270.024
centrosome cycleGO:0007098320.024
regulation of immune responseGO:00507762010.024
Mouse
regulation of neural precursor cell proliferationGO:200017740.024
regulation of protein localization to nucleusGO:1900180850.024
circulatory system developmentGO:00723592620.023
regulation of cellular component movementGO:00512703340.023
ripoptosome assemblyGO:009734310.023
protein localization to mitochondrionGO:0070585250.023
anterior posterior axis specificationGO:000994820.023
generation of neuronsGO:00486991520.023
Fly
rna processingGO:00063962550.023
positive regulation of lymphocyte activationGO:0051251730.023
cilium morphogenesisGO:0060271750.022
protein localization to nucleusGO:00345041360.022
spermatid developmentGO:000728640.022
regulation of peptide transportGO:0090087620.022
type i interferon biosynthetic processGO:004535140.022
Mouse
neurogenesisGO:00220081690.022
Fly
positive regulation of cellular component organizationGO:00511303760.021
hematopoietic or lymphoid organ developmentGO:00485341860.021
purine ribonucleoside triphosphate metabolic processGO:00092054110.020
memoryGO:000761330.020
regulation of endopeptidase activityGO:00525481700.020
Fly
detection of mechanical stimulusGO:005098240.020
ribonucleoprotein complex biogenesisGO:00226131160.020
regulation of protein localizationGO:00328802960.020
chromatin modificationGO:00165682980.020
regulation of tor signalingGO:0032006300.020
positive regulation of type i interferon mediated signaling pathwayGO:006034040.020
inorganic cation transmembrane transportGO:00986621940.020
response to biotic stimulusGO:00096072760.020
Mouse
cytokine mediated signaling pathwayGO:00192211090.020
cell projection assemblyGO:00300311260.019
oocyte developmentGO:004859910.019
purine containing compound catabolic processGO:00725234110.019
negative regulation of cell cycle processGO:00109481210.019
negative regulation of cell morphogenesis involved in differentiationGO:0010771240.019
somite developmentGO:006105370.019
regulation of anatomical structure morphogenesisGO:00226032860.019
maintenance of locationGO:00512351120.019
oocyte differentiationGO:000999420.019
regulation of intracellular protein transportGO:00331571230.019
cell projection organizationGO:00300302520.019
nitrogen compound transportGO:00717051910.019
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555440.019
negative regulation of protein processingGO:00109551420.018
response to growth factorGO:00708482050.018
cell cell signalingGO:00072671550.018
organelle assemblyGO:00709251760.018
protein modification by small protein removalGO:0070646920.018
regulation of meiosisGO:004002030.018
cellular response to oxidative stressGO:0034599850.018
regulation of transferase activityGO:00513383550.017
negative regulation of cell developmentGO:0010721480.017
purine nucleoside catabolic processGO:00061523980.017
regulation of proteasomal protein catabolic processGO:0061136870.017
positive regulation of response to external stimulusGO:0032103880.017
chemotaxisGO:00069351570.017
transcription factor import into nucleusGO:0042991400.017
gtp metabolic processGO:00460392390.017
synaptic vesicle recyclingGO:003646530.017
dna conformation changeGO:00711031130.017
negative regulation of cellular protein metabolic processGO:00322693530.017
actin mediated cell contractionGO:0070252120.017
nucleic acid phosphodiester bond hydrolysisGO:00903051020.017
female gamete generationGO:000729220.017
negative regulation of peptidase activityGO:0010466910.016
apoptotic mitochondrial changesGO:0008637570.016
mitotic cell cycle checkpointGO:0007093680.016
regulation of leukocyte activationGO:00026941150.016
secretionGO:00469032540.016
ribonucleoside catabolic processGO:00424544060.016
vasodilationGO:004231140.016
peptidyl serine modificationGO:00182091060.016
Human Fly
exocytosisGO:0006887710.016
nucleoside triphosphate catabolic processGO:00091433940.016
leukocyte activationGO:00453211640.016
Mouse
regulation of ion transportGO:00432691890.015
metal ion homeostasisGO:00550651690.015
regulation of response to cytokine stimulusGO:0060759460.015
negative regulation of intracellular signal transductionGO:19025321830.015
ribonucleoside triphosphate metabolic processGO:00091994120.015
regulation of bindingGO:00510981110.015
ubiquitin dependent protein catabolic processGO:00065112060.015
purine ribonucleotide catabolic processGO:00091544040.015
ncrna metabolic processGO:00346601080.015
cilium assemblyGO:0042384630.015
regulation of microtubule based processGO:0032886740.015
negative regulation of intracellular transportGO:0032387600.015
nucleoside monophosphate metabolic processGO:00091231910.015
membrane fusionGO:0061025430.015
er associated ubiquitin dependent protein catabolic processGO:0030433310.015
syncytium formation by plasma membrane fusionGO:000076820.015
embryonic epithelial tube formationGO:000183840.015
signal transduction by phosphorylationGO:00230142970.014
Human
regulation of apoptotic signaling pathwayGO:20012331750.014
mitotic cell cycle processGO:19030472860.014
nuclear importGO:00511701060.014
purine ribonucleoside monophosphate catabolic processGO:00091691580.014
cation homeostasisGO:00550801890.014
glycosyl compound catabolic processGO:19016584130.014
blastoderm segmentationGO:000735020.014
purine ribonucleoside metabolic processGO:00461284370.014
detection of mechanical stimulus involved in sensory perceptionGO:005097410.014
regulation of cell migrationGO:00303342890.014
purine ribonucleoside monophosphate metabolic processGO:00091671860.014
skin developmentGO:0043588760.014
positive regulation of protein transportGO:00512221350.014
regulation of cytokine biosynthetic processGO:0042035350.014
Mouse
regulation of lymphocyte activationGO:00512491030.014
negative regulation of chromosome organizationGO:2001251480.014
cell morphogenesisGO:00009022960.014
Fly
embryo developmentGO:00097901230.014
mitotic nuclear divisionGO:00070671190.014
cellular cation homeostasisGO:00300031630.014
regulation of protein import into nucleusGO:0042306780.014
mitochondrial transportGO:0006839600.013
head developmentGO:00603221080.013
growthGO:00400072020.013
regulation of organelle assemblyGO:1902115400.013
ribonucleoside monophosphate catabolic processGO:00091581580.013
cellular component assembly involved in morphogenesisGO:0010927730.013
regulation of body fluid levelsGO:0050878990.013
regulation of defense responseGO:00313471540.013
Mouse
response to inorganic substanceGO:00100351270.013
protein modification by small protein conjugationGO:00324463420.013
wnt signaling pathwayGO:00160551560.013
golgi vesicle transportGO:0048193800.013
autophagyGO:0006914880.013
negative regulation of cytoplasmic transportGO:1903650460.013
interleukin 6 productionGO:0032635370.013
response to toxic substanceGO:0009636370.013
t cell activationGO:0042110990.012
negative regulation of protein localization to nucleusGO:1900181340.012
fibroblast proliferationGO:0048144330.012
negative regulation of catalytic activityGO:00430863350.012
regulation of protein maturationGO:19033171500.012
gtp catabolic processGO:00061842370.012
synaptic transmissionGO:0007268610.012
protein refoldingGO:0042026140.012
hindbrain developmentGO:003090230.012
regulation of neurotransmitter levelsGO:0001505150.012
mitotic cell cycle phase transitionGO:00447721620.012
posttranscriptional regulation of gene expressionGO:00106082130.012
regulation of protein processingGO:00706131500.012
receptor recyclingGO:0001881150.012
regulation of microtubule cytoskeleton organizationGO:0070507610.012
negative regulation of mitotic cell cycle phase transitionGO:1901991850.012
cognitionGO:0050890430.012
amide transportGO:0042886760.012
pattern specification processGO:0007389430.012
tissue regenerationGO:004224630.012
positive regulation of homeostatic processGO:0032846470.011
chromatin assembly or disassemblyGO:0006333780.011
negative regulation of mitotic cell cycleGO:00459301020.011
response to interferon gammaGO:0034341390.011
negative regulation of proteolysisGO:00458611320.011
positive regulation of neural precursor cell proliferationGO:200017920.011
actin cytoskeleton organizationGO:00300362070.011
Fly
response to hydrogen peroxideGO:0042542400.011
sensory perceptionGO:00076001030.011
production of molecular mediator of immune responseGO:0002440370.011
regulation of protein serine threonine kinase activityGO:00719001790.011
regulation of cell morphogenesisGO:00226041530.011
neuron projection developmentGO:00311751060.011
cellular response to type i interferonGO:0071357120.011
epithelial cell proliferationGO:00506731280.011
response to extracellular stimulusGO:0009991850.011
reactive nitrogen species metabolic processGO:200105730.011
negative regulation of immune effector processGO:0002698380.011
response to starvationGO:0042594590.011
negative regulation of catabolic processGO:00098951040.011
cell projection morphogenesisGO:00488581290.011
negative regulation of cell proliferationGO:00082852280.011
single organism cell adhesionGO:00986021790.011
regulation of stress activated protein kinase signaling cascadeGO:0070302850.011
stress activated mapk cascadeGO:0051403930.011
rna catabolic processGO:0006401710.010
sleepGO:003043120.010
negative regulation of cell growthGO:0030308830.010
nucleoside phosphate catabolic processGO:19012924120.010
positive regulation of cell motilityGO:20001471770.010
cell part morphogenesisGO:00329901370.010
cardiovascular system developmentGO:00723582620.010
glycoprotein metabolic processGO:00091001100.010
negative regulation of i kappab kinase nf kappab signalingGO:0043124320.010
ribonucleotide catabolic processGO:00092614050.010
cellular metal ion homeostasisGO:00068751460.010
rhythmic behaviorGO:000762220.010
defense response to other organismGO:00985421290.010
Mouse

TBK1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:8634310.806
central nervous system diseaseDOID:3311860.806
eye diseaseDOID:56141490.160
eye and adnexa diseaseDOID:14921500.160
sensory system diseaseDOID:00501552030.160
glaucomaDOID:168680.160
retinal diseaseDOID:56791180.160
retinal degenerationDOID:8466890.160
immune system diseaseDOID:29141550.071
hematopoietic system diseaseDOID:741000.030
neurodegenerative diseaseDOID:12891020.016
disease of cellular proliferationDOID:145661740.013
skin diseaseDOID:37330.010
integumentary system diseaseDOID:16430.010
organ system cancerDOID:00506861640.010
cancerDOID:1621670.010
breast cancerDOID:1612210.010
thoracic cancerDOID:5093210.010