Homo sapiens

0 known processes

XPNPEP2

X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound

(Aliases: APP2)

XPNPEP2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
anion transportGO:00068201610.217
transmembrane transportGO:00550853990.154
cation transportGO:00068123310.139
urate transportGO:001574730.137
system processGO:00030083490.111
lipid metabolic processGO:00066293810.101
organic anion transportGO:00157111030.091
chemical homeostasisGO:00488783060.089
ion transmembrane transportGO:00342203380.087
cellular lipid metabolic processGO:00442553030.080
metal ion transportGO:00300012720.079
cellular amino acid metabolic processGO:00065201160.076
cation transmembrane transportGO:00986552380.074
cellular amine metabolic processGO:0044106410.074
lipid biosynthetic processGO:00086101770.073
response to oxygen containing compoundGO:19017003690.070
alpha ketoglutarate transportGO:001574210.070
positive regulation of intestinal epithelial structure maintenanceGO:006073110.068
response to biotic stimulusGO:00096072760.067
regulation of hormone levelsGO:00108171250.065
carboxylic acid transportGO:0046942630.064
monocarboxylic acid metabolic processGO:00327871850.063
post embryonic developmentGO:000979120.062
amine metabolic processGO:0009308440.062
regulation of cellular ketone metabolic processGO:0010565500.061
regulation of cellular component movementGO:00512703340.059
small molecule biosynthetic processGO:00442831570.059
nitrogen compound transportGO:00717051910.058
organic acid transportGO:0015849650.056
response to external biotic stimulusGO:00432072610.054
negative regulation of cell deathGO:00605483450.052
ion homeostasisGO:00508012300.051
carnitine transmembrane transportGO:190260330.051
response to other organismGO:00517072610.051
regulation of nucleotide metabolic processGO:00061402690.051
positive regulation of ion transportGO:0043270870.050
positive regulation of immune system processGO:00026842830.049
locomotory behaviorGO:000762610.048
negative regulation of apoptotic processGO:00430663160.047
immune responseGO:00069553070.047
regulation of cellular amine metabolic processGO:0033238110.047
small gtpase mediated signal transductionGO:0007264780.046
positive regulation of nucleotide metabolic processGO:00459812300.045
inorganic ion transmembrane transportGO:00986602310.044
carbohydrate derivative biosynthetic processGO:19011372070.044
regulation of cellular amino acid metabolic processGO:000652160.044
cellular metal ion homeostasisGO:00068751460.044
organic hydroxy compound transportGO:0015850630.043
negative regulation of programmed cell deathGO:00430693210.043
cellular response to oxygen containing compoundGO:19017012760.043
response to organonitrogen compoundGO:00102431560.042
enzyme linked receptor protein signaling pathwayGO:00071673030.041
purine ribonucleoside metabolic processGO:00461284370.041
cellular ketone metabolic processGO:0042180800.041
cellular divalent inorganic cation homeostasisGO:00725031280.040
regulation of cell differentiationGO:00455953930.040
positive regulation of cellular amino acid metabolic processGO:004576430.040
multicellular organismal agingGO:001025930.040
negative regulation of protein metabolic processGO:00512483910.039
regulation of cell motilityGO:20001452990.039
cellular chemical homeostasisGO:00550821800.039
determination of adult lifespanGO:000834020.037
secretionGO:00469032540.037
cellular homeostasisGO:00197251960.037
regulation of purine nucleotide metabolic processGO:19005422640.036
organonitrogen compound biosynthetic processGO:19015662000.036
ras protein signal transductionGO:0007265730.036
alcohol metabolic processGO:00060661140.036
drinking behaviorGO:004275610.035
response to bacteriumGO:00096171440.035
regulation of ion transportGO:00432691890.035
regulation of cell migrationGO:00303342890.035
segmentationGO:003528240.034
positive regulation of cellular amine metabolic processGO:003324070.034
defense responseGO:00069523150.034
protein maturationGO:00516042330.034
female gamete generationGO:000729220.034
calcium ion homeostasisGO:00550741220.034
regulation of anatomical structure morphogenesisGO:00226032860.033
fatty acid metabolic processGO:00066311150.033
short chain fatty acid importGO:001591310.033
nervous system developmentGO:00073992930.033
carboxylic acid biosynthetic processGO:0046394970.033
nucleotide catabolic processGO:00091664080.032
regulation of response to external stimulusGO:00321012220.032
cellular cation homeostasisGO:00300031630.032
sulfur compound metabolic processGO:00067901010.032
carbohydrate metabolic processGO:00059752070.031
response to nitrogen compoundGO:19016981840.031
nucleoside triphosphate metabolic processGO:00091414220.031
organic hydroxy compound metabolic processGO:19016151470.031
single organism cellular localizationGO:19025803320.031
positive regulation of cell proliferationGO:00082843010.031
protein oligomerizationGO:00512591730.031
regulation of immune responseGO:00507762010.031
ribonucleoside catabolic processGO:00424544060.031
positive regulation of developmental processGO:00510943140.031
positive regulation of cellular component organizationGO:00511303760.030
cytoplasmic transportGO:00164823790.030
negative regulation of catalytic activityGO:00430863350.030
positive regulation of digestive system processGO:006045620.030
positive regulation of cell migrationGO:00303351720.030
leukocyte migrationGO:00509001070.030
interspecies interaction between organismsGO:00444191560.030
cellular ion homeostasisGO:00068731680.030
ribonucleoside triphosphate metabolic processGO:00091994120.030
purine ribonucleotide catabolic processGO:00091544040.030
divalent inorganic cation homeostasisGO:00725071360.029
single organism carbohydrate metabolic processGO:00447231930.029
cation homeostasisGO:00550801890.029
negative regulation of cell proliferationGO:00082852280.029
regulation of locomotionGO:00400123290.029
regulation of cellular component biogenesisGO:00440872810.029
vesicle mediated transportGO:00161923710.029
positive regulation of protein phosphorylationGO:00019343130.028
response to lipidGO:00339932060.028
cell adhesionGO:00071553250.028
inner ear morphogenesisGO:004247240.028
biological adhesionGO:00226103310.028
glycine importGO:003623310.028
positive regulation of nucleotide catabolic processGO:00308131850.028
lipid catabolic processGO:0016042840.028
positive regulation of cellular component movementGO:00512721810.028
regulation of proteolysisGO:00301622930.028
actin filament based processGO:00300292240.028
sodium independent organic anion transportGO:004325220.028
positive regulation of purine nucleotide metabolic processGO:19005442270.027
nicotinate transportGO:200114210.027
negative regulation of phosphate metabolic processGO:00459362670.027
regulation of response to woundingGO:19030341010.027
protein processingGO:00164852260.027
divalent metal ion transportGO:00708381520.026
glycosyl compound catabolic processGO:19016584130.026
cell developmentGO:00484683280.026
negative regulation of cellular protein metabolic processGO:00322693530.026
regulation of system processGO:00440571010.026
ribonucleotide catabolic processGO:00092614050.026
purine containing compound catabolic processGO:00725234110.026
single organism membrane organizationGO:00448022680.026
ribonucleoside triphosphate catabolic processGO:00092033910.026
maintenance of locationGO:00512351120.026
mesonephric tubule formationGO:007217210.025
monocarboxylic acid biosynthetic processGO:0072330670.025
purine nucleoside triphosphate catabolic processGO:00091463920.025
organophosphate catabolic processGO:00464344300.025
metal ion homeostasisGO:00550651690.025
oxidation reduction processGO:00551143960.025
organic acid biosynthetic processGO:0016053970.025
innate immune responseGO:00450871780.025
positive regulation of immune responseGO:00507781590.025
cellular response to endogenous stimulusGO:00714953360.025
cell morphogenesisGO:00009022960.025
nucleoside phosphate catabolic processGO:19012924120.025
positive regulation of hydrolase activityGO:00513453310.025
quorum sensing involved in interaction with hostGO:005210610.025
g protein coupled receptor signaling pathwayGO:00071862070.025
purine ribonucleoside triphosphate catabolic processGO:00092073910.025
blastoderm segmentationGO:000735020.024
negative regulation of multicellular organismal processGO:00512413170.024
lipid transportGO:0006869900.024
regulation of secretionGO:00510461940.024
toxin metabolic processGO:000940440.024
regenerationGO:003109940.024
negative regulation of phosphorus metabolic processGO:00105632670.024
mesonephric duct developmentGO:007217730.024
sensory perception of painGO:001923340.024
oogenesisGO:004847720.024
positive regulation of cellular catabolic processGO:00313312840.024
regulation of protein maturationGO:19033171500.024
reactive oxygen species metabolic processGO:0072593750.024
negative regulation of developmental processGO:00510932470.024
intracellular protein transportGO:00068862700.023
regulation of intracellular transportGO:00323861950.023
positive regulation of catabolic processGO:00098963100.023
morphogenesis of embryonic epitheliumGO:001633140.023
regulation of kinase activityGO:00435493140.023
nucleoside catabolic processGO:00091644080.023
cofactor metabolic processGO:0051186870.023
guanosine containing compound catabolic processGO:19010692390.023
membrane organizationGO:00610242920.023
regulation of transferase activityGO:00513383550.023
regulation of ion transmembrane transportGO:00347651320.023
divalent inorganic cation transportGO:00725111580.023
rho protein signal transductionGO:0007266260.023
negative regulation of cellular component organizationGO:00511292350.023
regulation of mapk cascadeGO:00434082620.023
cellular macromolecule catabolic processGO:00442653800.022
purine nucleoside triphosphate metabolic processGO:00091444120.022
steroid metabolic processGO:0008202940.022
response to woundingGO:00096111680.022
mapk cascadeGO:00001652880.022
immune effector processGO:00022521590.022
neurological system processGO:00508771630.022
cardiac muscle cell contractionGO:008600340.022
regulation of actin filament based processGO:00329701410.022
negative regulation of kidney developmentGO:009018520.022
purine nucleotide catabolic processGO:00061954050.022
calcium ion transportGO:00068161470.022
renal tubular secretionGO:009725410.022
response to organic cyclic compoundGO:00140702040.022
anion transmembrane transportGO:0098656760.022
sequestering of calcium ionGO:0051208170.022
regulation of protein kinase activityGO:00458592890.021
guanosine containing compound metabolic processGO:19010682440.021
adult locomotory behaviorGO:000834410.021
negative regulation of cellular amino acid metabolic processGO:004576320.021
positive regulation of cell motilityGO:20001471770.021
amino acid transportGO:0006865280.021
purine ribonucleoside catabolic processGO:00461303980.021
organophosphate biosynthetic processGO:00904071630.021
regulation of multi organism processGO:00439001570.021
follicle stimulating hormone secretionGO:004688430.020
regulation of nucleoside metabolic processGO:00091182090.020
neuromuscular junction developmentGO:000752830.020
inorganic cation transmembrane transportGO:00986621940.020
cellular response to nitrogen compoundGO:19016991440.020
somatic stem cell maintenanceGO:003501940.020
regulation of protein localizationGO:00328802960.020
dephosphorylationGO:00163112090.020
protein catabolic processGO:00301633250.020
renal system processGO:0003014250.020
positive regulation of purine nucleotide catabolic processGO:00331231850.020
response to abiotic stimulusGO:00096283360.020
purine ribonucleoside triphosphate metabolic processGO:00092054110.020
cellular component morphogenesisGO:00329893140.020
cellular calcium ion homeostasisGO:00068741170.020
urate metabolic processGO:0046415110.020
epithelium developmentGO:00604292270.020
negative regulation of protein processingGO:00109551420.020
defense response to other organismGO:00985421290.020
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.020
fatty acid biosynthetic processGO:0006633460.019
negative regulation of hydrolase activityGO:00513461820.019
regulation of purine nucleotide catabolic processGO:00331212050.019
regulation of gtp catabolic processGO:00331241800.019
cell cell signalingGO:00072671550.019
memoryGO:000761330.019
glycerolipid metabolic processGO:00464861070.019
sequestering of metal ionGO:0051238240.019
response to growth factorGO:00708482050.019
chemotaxisGO:00069351570.019
apoptotic signaling pathwayGO:00971902680.019
positive regulation of cell deathGO:00109422630.019
ribonucleotide biosynthetic processGO:0009260810.019
regulation of cytoskeleton organizationGO:00514931770.019
regulation of ion homeostasisGO:2000021730.019
cd8 positive alpha beta t cell activationGO:003603730.019
response to mercury ionGO:004668940.019
positive regulation of transferase activityGO:00513472270.019
regulation of protein complex assemblyGO:00432541470.019
actin cytoskeleton organizationGO:00300362070.019
response to metal ionGO:0010038840.018
regulation of defense responseGO:00313471540.018
signal transduction by phosphorylationGO:00230142970.018
positive regulation of organelle organizationGO:00106381950.018
positive regulation of cellular component biogenesisGO:00440891580.018
negative regulation of cellular amine metabolic processGO:003323930.018
gtp catabolic processGO:00061842370.018
anterior posterior axis specificationGO:000994820.018
response to drugGO:0042493810.018
purine containing compound biosynthetic processGO:0072522880.018
response to inorganic substanceGO:00100351270.018
regulation of cell cycle processGO:00105642660.018
positive regulation of phosphorylationGO:00423273940.018
positive regulation of ras gtpase activityGO:00323201170.018
positive regulation of synaptic transmissionGO:005080640.018
regulation of protein processingGO:00706131500.018
cell projection organizationGO:00300302520.018
cellular protein complex assemblyGO:00436231880.018
negative regulation of proteolysisGO:00458611320.018
nucleoside phosphate biosynthetic processGO:19012931090.018
ribose phosphate biosynthetic processGO:0046390820.018
positive regulation of programmed cell deathGO:00430682490.017
regulation of small gtpase mediated signal transductionGO:00510561560.017
lipid localizationGO:00108761060.017
tripartite regional subdivisionGO:000735120.017
embryonic epithelial tube formationGO:000183840.017
protein targetingGO:00066051870.017
sensory perceptionGO:00076001030.017
negative regulation of protein maturationGO:19033181420.017
behaviorGO:00076101120.017
response to organophosphorusGO:0046683410.017
cell activationGO:00017752130.017
regulation of cytokine productionGO:00018172320.017
mitotic cell cycle processGO:19030472860.017
negative regulation of protein modification processGO:00314002000.017
regulation of ras protein signal transductionGO:00465781550.017
positive regulation of organic acid transportGO:003289230.017
positive regulation of nucleoside metabolic processGO:00459791860.017
protein homooligomerizationGO:00512601000.017
circadian behaviorGO:004851220.017
positive regulation of mapk cascadeGO:00434101900.017
purine nucleotide biosynthetic processGO:0006164840.017
anterior posterior axis specification embryoGO:000859520.017
cellular macromolecular complex assemblyGO:00346223240.017
endodermal cell fate specificationGO:000171440.017
rhythmic behaviorGO:000762220.016
regulation of establishment of protein localizationGO:00702012420.016
proteolysis involved in cellular protein catabolic processGO:00516032440.016
taxisGO:00423301570.016
cellular response to abiotic stimulusGO:00712141170.016
developmental programmed cell deathGO:001062330.016
symbiosis encompassing mutualism through parasitismGO:00444031560.016
regulation of immune effector processGO:0002697910.016
regulation of anatomical structure sizeGO:00900661010.016
regulation of calcium ion transportGO:0051924790.016
cytokine productionGO:00018162470.016
blood vessel developmentGO:00015681720.016
9 cis retinoic acid metabolic processGO:004290510.016
cellular protein catabolic processGO:00442572610.016
regulation of transmembrane transportGO:00347621390.016
regulation of cell cycleGO:00517263930.016
single organism cell adhesionGO:00986021790.016
nucleoside triphosphate catabolic processGO:00091433940.016
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.016
oocyte developmentGO:004859910.016
growthGO:00400072020.016
multi organism cellular processGO:00447641560.016
regulation of blood circulationGO:1903522590.016
regulation of sequence specific dna binding transcription factor activityGO:00510902110.016
postsynaptic membrane organizationGO:000194120.016
epithelial cell proliferationGO:00506731280.016
regulation of protein transportGO:00512232130.016
positive regulation of gtp catabolic processGO:00331261660.016
oocyte differentiationGO:000999420.015
anatomical structure formation involved in morphogenesisGO:00486462840.015
monocarboxylic acid transportGO:0015718320.015
embryonic forelimb morphogenesisGO:003511540.015
regulation of cell adhesionGO:00301551660.015
regulation of apoptotic signaling pathwayGO:20012331750.015
glycine transportGO:001581630.015
negative regulation of cell differentiationGO:00455961710.015
cellular response to dna damage stimulusGO:00069743790.015
sodium dependent organic cation transportGO:007071510.015
response to acid chemicalGO:0001101660.015
response to hormoneGO:00097251750.015
endocytosisGO:00068971590.015
serotonin uptakeGO:005161020.015
vasodilationGO:004231140.015
amide transportGO:0042886760.015
purine nucleoside catabolic processGO:00061523980.015
regulation of branching involved in ureteric bud morphogenesisGO:009018930.015
protein localization to organelleGO:00333652800.015
mitotic cell cycleGO:00002783260.015
positive regulation of intracellular transportGO:00323881040.015
regulation of i kappab kinase nf kappab signalingGO:00431221620.015
regulation of reactive oxygen species metabolic processGO:2000377410.015
endodermal cell fate commitmentGO:000171140.015
cyclic nucleotide biosynthetic processGO:0009190610.015
regulation of phospholipase c activating g protein coupled receptor signaling pathwayGO:190073610.015
protein localization to membraneGO:00726571600.015
gtp metabolic processGO:00460392390.015
actin mediated cell contractionGO:0070252120.015
epithelial cell differentiationGO:00308551410.015
organic hydroxy compound biosynthetic processGO:1901617710.015
regulation of homeostatic processGO:00328441210.015
l amino acid importGO:004309240.015
regulation of body fluid levelsGO:0050878990.015
regulation of reactive oxygen species biosynthetic processGO:190342630.015
regulation of metal ion transportGO:00109591200.015
cellular component disassemblyGO:0022411920.015
positive regulation of kinase activityGO:00336742040.015
quorum sensingGO:000937210.015
positive regulation of apoptotic processGO:00430652460.015
positive regulation of reactive oxygen species metabolic processGO:2000379240.015
positive regulation of transportGO:00510503360.014
cytosolic calcium ion homeostasisGO:0051480890.014
negative regulation of locomotionGO:00400131180.014
motor neuron axon guidanceGO:000804520.014
endomembrane system organizationGO:00102561960.014
activation of immune responseGO:00022531140.014
cellular response to growth factor stimulusGO:00713631970.014
posttranscriptional regulation of gene expressionGO:00106082130.014
reactive oxygen species biosynthetic processGO:190340940.014
single organismal cell cell adhesionGO:00163371480.014
phospholipid metabolic processGO:0006644990.014
spermatid differentiationGO:004851540.014
short chain fatty acid transportGO:001591210.014
regulation of nucleotide catabolic processGO:00308112050.014
cell part morphogenesisGO:00329901370.014
regulation of gtpase activityGO:00430871800.014
cell type specific apoptotic processGO:00972851250.014
hindbrain developmentGO:003090230.014
regulation of cytoplasmic transportGO:19036491490.014
glycoprotein metabolic processGO:00091001100.014
negative regulation of cell motilityGO:20001461040.014
positive regulation of cytoskeleton organizationGO:0051495830.014
nephric duct developmentGO:007217640.014
purine ribonucleotide biosynthetic processGO:0009152790.014
regulation of leukocyte migrationGO:0002685630.014
organ formationGO:004864530.014
coenzyme metabolic processGO:0006732650.014
negative regulation of response to woundingGO:1903035470.014
response to purine containing compoundGO:0014074400.014
cellular response to organonitrogen compoundGO:00714171240.014
positive regulation of gtpase activityGO:00435471660.014
testosterone biosynthetic processGO:006137020.014
visual behaviorGO:000763220.014
generation of neuronsGO:00486991520.014
hormone metabolic processGO:0042445610.014
reactive nitrogen species metabolic processGO:200105730.014
peripheral nervous system developmentGO:000742220.014
blood circulationGO:00080151130.014
negative regulation of transportGO:00510511760.014
cellular modified amino acid metabolic processGO:0006575640.014
ectodermal placode formationGO:006078810.014
regulation of mesonephros developmentGO:006121730.014
secretion by cellGO:00329402260.014
wnt signaling pathwayGO:00160551560.014
regulation of growthGO:00400081650.014
negative regulation of androgen biosynthetic processGO:200018010.014
regulation of cell activationGO:00508651250.014
amino acid importGO:004309040.014
negative regulation of cell migrationGO:00303361020.013
regulation of ras gtpase activityGO:00323181280.013
inflammatory responseGO:0006954790.013
muscle system processGO:0003012810.013
positive regulation of locomotionGO:00400171860.013
cellular response to organic cyclic compoundGO:00714071270.013
actin filament organizationGO:00070151280.013
neurogenesisGO:00220081690.013
response to axon injuryGO:004867810.013
synaptic transmission glycinergicGO:006001210.013
regulation of membrane potentialGO:0042391950.013
cellular response to hormone stimulusGO:00328701250.013
protein ubiquitinationGO:00165673140.013
negative regulation of intracellular signal transductionGO:19025321830.013
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.013
nucleotide biosynthetic processGO:00091651090.013
nucleocytoplasmic transportGO:00069131760.013
regulation of endopeptidase activityGO:00525481700.013
androgen biosynthetic processGO:000670230.013
establishment of protein localization to membraneGO:00901501210.013
response to cytokineGO:00340972320.013
purine ribonucleoside monophosphate metabolic processGO:00091671860.013
positive regulation of cytoplasmic transportGO:1903651820.013
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.013
purine nucleoside monophosphate metabolic processGO:00091261860.013
defense response to bacteriumGO:0042742630.013
negative regulation of cell cycleGO:00457861930.013
immune system developmentGO:00025201950.013
serotonin transportGO:000683730.013
compound eye developmentGO:004874910.013
negative regulation of phosphorylationGO:00423261740.013
circulatory system processGO:00030131130.013
regulation of peptidase activityGO:00525471800.013
anatomical structure homeostasisGO:00602491000.013
regulation of cellular response to stressGO:00801352440.013
response to activityGO:001482300.013
response to disaccharideGO:003428510.013
cyclic nucleotide metabolic processGO:0009187820.013
luteinizing hormone secretionGO:003227510.013
cardiac muscle contractionGO:0060048340.013
regulation of synaptic plasticityGO:004816730.013
negative regulation of immune system processGO:00026831360.013
forelimb morphogenesisGO:003513640.012
regulation of neural precursor cell proliferationGO:200017740.012
positive regulation of fatty acid transportGO:200019330.012
positive regulation of cardioblast differentiationGO:005189120.012
salivary gland morphogenesisGO:000743540.012
hematopoietic or lymphoid organ developmentGO:00485341860.012
regulation of wnt signaling pathwayGO:00301111230.012
isoprenoid metabolic processGO:0006720390.012
regulation of protein catabolic processGO:00421761550.012
response to virusGO:00096151260.012
establishment of protein localization to organelleGO:00725941720.012
photoreceptor cell differentiationGO:004653020.012
cell projection assemblyGO:00300311260.012
monovalent inorganic cation transportGO:00156721280.012
regulation of cell developmentGO:00602841610.012
glycoprotein biosynthetic processGO:0009101910.012
cell chemotaxisGO:00603261120.012

XPNPEP2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.085
urinary system diseaseDOID:18400.058
kidney diseaseDOID:557360.058
renal tubular transport diseaseDOID:447110.058
inherited metabolic disorderDOID:6552420.039
disease of cellular proliferationDOID:145661740.030
nervous system diseaseDOID:8634310.030
central nervous system diseaseDOID:3311860.030
cancerDOID:1621670.029
organ system cancerDOID:00506861640.029
sensory system diseaseDOID:00501552030.027
musculoskeletal system diseaseDOID:172230.021
eye diseaseDOID:56141490.019
eye and adnexa diseaseDOID:14921500.019
acquired metabolic diseaseDOID:0060158580.017
cardiovascular system diseaseDOID:12871060.016
neurodegenerative diseaseDOID:12891020.015
immune system diseaseDOID:29141550.014
retinal diseaseDOID:56791180.014
retinal degenerationDOID:8466890.013
connective tissue diseaseDOID:651090.012