Homo sapiens

398 known processes

GPER

G protein-coupled estrogen receptor 1

(Aliases: MGC99678,CEPR,LERGU,LERGU2,FEG-1,LyGPR,GPCR-Br,GPR30,CMKRL2,DRY12)

GPER biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular ketone metabolic processGO:0042180800.150
regulation of cellular ketone metabolic processGO:0010565500.109
cellular amine metabolic processGO:0044106410.109
cellular amino acid metabolic processGO:00065201160.103
regulation of cellular amine metabolic processGO:0033238110.101
chemical homeostasisGO:00488783060.097
amine metabolic processGO:0009308440.094
positive regulation of phosphorylationGO:00423273940.076
regulation of cellular amino acid metabolic processGO:000652160.075
positive regulation of cellular amino acid metabolic processGO:004576430.072
metal ion transportGO:00300012720.071
cation transportGO:00068123310.071
system processGO:00030083490.067
positive regulation of protein phosphorylationGO:00019343130.066
post embryonic developmentGO:000979120.064
lipid metabolic processGO:00066293810.064
Mouse
ion homeostasisGO:00508012300.062
response to oxygen containing compoundGO:19017003690.060
regulation of mapk cascadeGO:00434082620.060
organonitrogen compound biosynthetic processGO:19015662000.059
positive regulation of cellular amine metabolic processGO:003324070.058
regulation of cellular component movementGO:00512703340.057
mapk cascadeGO:00001652880.056
nucleoside catabolic processGO:00091644080.055
cellular lipid metabolic processGO:00442553030.054
locomotory behaviorGO:000762610.053
positive regulation of transportGO:00510503360.053
small gtpase mediated signal transductionGO:0007264780.053
regulation of nucleotide metabolic processGO:00061402690.052
g protein coupled receptor signaling pathwayGO:00071862070.052
response to abiotic stimulusGO:00096283360.052
purine containing compound catabolic processGO:00725234110.051
transmembrane transportGO:00550853990.050
organophosphate catabolic processGO:00464344300.050
positive regulation of cellular component organizationGO:00511303760.050
cellular response to endogenous stimulusGO:00714953360.049
regulation of cell migrationGO:00303342890.049
defense responseGO:00069523150.048
ribonucleotide catabolic processGO:00092614050.048
multicellular organismal agingGO:001025930.047
forebrain generation of neuronsGO:002187230.047
regulation of purine nucleotide metabolic processGO:19005422640.047
regulation of cell differentiationGO:00455953930.047
Mouse
ras protein signal transductionGO:0007265730.047
regulation of locomotionGO:00400123290.046
carbohydrate derivative biosynthetic processGO:19011372070.046
monocarboxylic acid metabolic processGO:00327871850.045
cation homeostasisGO:00550801890.045
signal transduction by phosphorylationGO:00230142970.045
nucleoside phosphate catabolic processGO:19012924120.043
enzyme linked receptor protein signaling pathwayGO:00071673030.043
purine nucleoside triphosphate catabolic processGO:00091463920.043
positive regulation of mapk cascadeGO:00434101900.043
negative regulation of catalytic activityGO:00430863350.042
regulation of protein kinase activityGO:00458592890.042
ribonucleoside catabolic processGO:00424544060.042
cation transmembrane transportGO:00986552380.042
nucleoside triphosphate catabolic processGO:00091433940.042
regulation of transferase activityGO:00513383550.041
cell adhesionGO:00071553250.041
negative regulation of phosphate metabolic processGO:00459362670.041
purine ribonucleoside metabolic processGO:00461284370.041
positive regulation of hydrolase activityGO:00513453310.041
Rat
determination of adult lifespanGO:000834020.040
nucleoside triphosphate metabolic processGO:00091414220.040
positive regulation of developmental processGO:00510943140.040
Mouse
purine nucleotide catabolic processGO:00061954050.039
purine ribonucleoside triphosphate catabolic processGO:00092073910.039
purine nucleoside catabolic processGO:00061523980.039
ribonucleoside triphosphate catabolic processGO:00092033910.039
purine ribonucleotide catabolic processGO:00091544040.039
negative regulation of cell deathGO:00605483450.038
cellular cation homeostasisGO:00300031630.038
purine ribonucleoside triphosphate metabolic processGO:00092054110.038
cytoplasmic transportGO:00164823790.038
cellular response to oxygen containing compoundGO:19017012760.038
cyclic nucleotide metabolic processGO:0009187820.037
negative regulation of programmed cell deathGO:00430693210.037
regulation of kinase activityGO:00435493140.037
glycosyl compound catabolic processGO:19016584130.037
positive regulation of nucleotide metabolic processGO:00459812300.037
nervous system developmentGO:00073992930.037
Mouse
regulation of cell motilityGO:20001452990.037
carbohydrate metabolic processGO:00059752070.036
negative regulation of multicellular organismal processGO:00512413170.036
ion transmembrane transportGO:00342203380.036
nucleoside phosphate biosynthetic processGO:19012931090.035
nucleotide catabolic processGO:00091664080.035
cyclic purine nucleotide metabolic processGO:0052652600.035
positive regulation of catabolic processGO:00098963100.035
response to hormoneGO:00097251750.035
actin filament based processGO:00300292240.034
ribonucleotide biosynthetic processGO:0009260810.034
cellular ion homeostasisGO:00068731680.034
cell developmentGO:00484683280.034
Mouse
purine nucleoside triphosphate metabolic processGO:00091444120.034
negative regulation of phosphorus metabolic processGO:00105632670.034
cell morphogenesisGO:00009022960.033
segmentationGO:003528240.033
regulation of protein localizationGO:00328802960.033
regulation of cellular component biogenesisGO:00440872810.033
purine ribonucleoside catabolic processGO:00461303980.033
ribonucleoside triphosphate metabolic processGO:00091994120.033
guanosine containing compound catabolic processGO:19010692390.033
negative regulation of cellular component organizationGO:00511292350.033
negative regulation of apoptotic processGO:00430663160.033
cellular homeostasisGO:00197251960.032
secretionGO:00469032540.032
Mouse
response to external biotic stimulusGO:00432072610.032
negative regulation of transportGO:00510511760.032
immune responseGO:00069553070.032
inorganic cation transmembrane transportGO:00986621940.032
cellular chemical homeostasisGO:00550821800.032
regulation of ion transportGO:00432691890.032
cellular metal ion homeostasisGO:00068751460.032
single organism carbohydrate metabolic processGO:00447231930.032
vesicle mediated transportGO:00161923710.031
regulation of anatomical structure morphogenesisGO:00226032860.031
positive regulation of cell proliferationGO:00082843010.031
metal ion homeostasisGO:00550651690.031
purine ribonucleotide biosynthetic processGO:0009152790.031
regulation of hormone levelsGO:00108171250.031
Mouse
female gamete generationGO:000729220.031
nitrogen compound transportGO:00717051910.031
Mouse
oogenesisGO:004847720.030
regulation of secretionGO:00510461940.030
Mouse
positive regulation of cellular catabolic processGO:00313312840.030
response to other organismGO:00517072610.030
negative regulation of protein metabolic processGO:00512483910.030
divalent inorganic cation homeostasisGO:00725071360.030
neurological system processGO:00508771630.029
response to nitrogen compoundGO:19016981840.029
inorganic ion transmembrane transportGO:00986602310.029
negative regulation of cellular protein metabolic processGO:00322693530.029
regulation of intracellular transportGO:00323861950.029
cellular component morphogenesisGO:00329893140.029
divalent inorganic cation transportGO:00725111580.029
protein maturationGO:00516042330.028
cell cell signalingGO:00072671550.028
Mouse
positive regulation of protein kinase activityGO:00458601900.028
regulation of cell cycleGO:00517263930.028
Mouse
positive regulation of cell deathGO:00109422630.028
Rat
organophosphate biosynthetic processGO:00904071630.028
small molecule biosynthetic processGO:00442831570.027
cell projection organizationGO:00300302520.027
single organism cellular localizationGO:19025803320.027
response to organic cyclic compoundGO:00140702040.027
calcium ion transportGO:00068161470.027
negative regulation of cell proliferationGO:00082852280.027
Rat
regulation of purine nucleotide catabolic processGO:00331212050.027
biological adhesionGO:00226103310.027
guanosine containing compound metabolic processGO:19010682440.027
reactive oxygen species metabolic processGO:0072593750.026
gtp metabolic processGO:00460392390.026
regulation of cell cycle processGO:00105642660.026
Mouse
positive regulation of purine nucleotide metabolic processGO:19005442270.026
regulation of cell growthGO:00015581350.026
positive regulation of cell motilityGO:20001471770.026
memoryGO:000761330.026
positive regulation of cell migrationGO:00303351720.026
gtp catabolic processGO:00061842370.026
response to woundingGO:00096111680.026
neuromuscular junction developmentGO:000752830.026
cyclic nucleotide biosynthetic processGO:0009190610.026
positive regulation of synaptic transmissionGO:005080640.025
divalent metal ion transportGO:00708381520.025
camp metabolic processGO:0046058610.025
purine nucleotide biosynthetic processGO:0006164840.025
blastoderm segmentationGO:000735020.025
mitotic cell cycleGO:00002783260.025
regulation of proteolysisGO:00301622930.025
Rat
cellular response to cytokine stimulusGO:00713451810.024
response to growth factorGO:00708482050.024
lipid biosynthetic processGO:00086101770.024
Mouse
regulation of gtp catabolic processGO:00331241800.024
actin cytoskeleton organizationGO:00300362070.024
organic hydroxy compound metabolic processGO:19016151470.024
response to cytokineGO:00340972320.024
positive regulation of kinase activityGO:00336742040.024
single organism membrane organizationGO:00448022680.024
protein catabolic processGO:00301633250.024
intracellular protein transportGO:00068862700.024
regulation of purine nucleotide biosynthetic processGO:1900371500.024
positive regulation of cytokine productionGO:00018191670.024
secretion by cellGO:00329402260.024
Mouse
cellular response to growth factor stimulusGO:00713631970.024
regenerationGO:003109940.024
protein localization to organelleGO:00333652800.024
rho protein signal transductionGO:0007266260.024
protein oligomerizationGO:00512591730.023
regulation of secretion by cellGO:19035301770.023
Mouse
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.023
regulation of metal ion transportGO:00109591200.023
regulation of response to external stimulusGO:00321012220.023
negative regulation of cellular amine metabolic processGO:003323930.023
forebrain neuron differentiationGO:002187930.023
calcium ion homeostasisGO:00550741220.023
positive regulation of transferase activityGO:00513472270.023
positive regulation of locomotionGO:00400171860.023
regulation of reactive oxygen species metabolic processGO:2000377410.023
dephosphorylationGO:00163112090.023
regulation of cyclase activityGO:0031279190.023
cytokine productionGO:00018162470.023
positive regulation of ion transportGO:0043270870.023
neurogenesisGO:00220081690.023
Mouse
regulation of nucleoside metabolic processGO:00091182090.023
regulation of cyclic nucleotide metabolic processGO:0030799630.023
oxidation reduction processGO:00551143960.023
regulation of cellular response to stressGO:00801352440.022
response to biotic stimulusGO:00096072760.022
cell growthGO:00160491600.022
cell fate determinationGO:000170930.022
nucleotide biosynthetic processGO:00091651090.022
apoptotic signaling pathwayGO:00971902680.022
Rat
regulation of defense responseGO:00313471540.022
regulation of protein transportGO:00512232130.022
regulation of establishment of protein localizationGO:00702012420.022
protein processingGO:00164852260.022
positive regulation of programmed cell deathGO:00430682490.022
Rat
regulation of cytokine productionGO:00018172320.022
positive regulation of immune system processGO:00026842830.022
negative regulation of intracellular signal transductionGO:19025321830.022
negative regulation of cellular amino acid metabolic processGO:004576320.022
anion transportGO:00068201610.022
regulation of cytoskeleton organizationGO:00514931770.022
neurotransmitter secretionGO:000726940.022
sensory perceptionGO:00076001030.022
rhythmic behaviorGO:000762220.022
regulation of gtpase activityGO:00430871800.021
positive regulation of purine nucleotide catabolic processGO:00331231850.021
regulation of protein serine threonine kinase activityGO:00719001790.021
adult locomotory behaviorGO:000834410.021
camp biosynthetic processGO:0006171470.021
regulation of small gtpase mediated signal transductionGO:00510561560.021
cellular macromolecule catabolic processGO:00442653800.021
fatty acid metabolic processGO:00066311150.021
positive regulation of apoptotic processGO:00430652460.021
Rat
membrane organizationGO:00610242920.021
positive regulation of nucleotide catabolic processGO:00308131850.021
pituitary gland developmentGO:002198320.021
regulation of nucleotide catabolic processGO:00308112050.021
generation of neuronsGO:00486991520.021
Mouse
positive regulation of nucleoside metabolic processGO:00459791860.021
cellular macromolecular complex assemblyGO:00346223240.021
negative regulation of hydrolase activityGO:00513461820.021
regulation of cell morphogenesisGO:00226041530.021
positive regulation of gtpase activityGO:00435471660.021
regulation of homeostatic processGO:00328441210.021
innate immune responseGO:00450871780.020
regulation of growthGO:00400081650.020
peptidyl tyrosine modificationGO:00182121700.020
ribose phosphate biosynthetic processGO:0046390820.020
regulation of cell developmentGO:00602841610.020
Mouse
negative regulation of developmental processGO:00510932470.020
Mouse
maintenance of locationGO:00512351120.020
organic acid biosynthetic processGO:0016053970.020
hindbrain developmentGO:003090230.020
cellular divalent inorganic cation homeostasisGO:00725031280.020
mitotic cell cycle processGO:19030472860.020
cardiovascular system developmentGO:00723582620.020
sulfur compound metabolic processGO:00067901010.020
inner ear morphogenesisGO:004247240.020
epithelium developmentGO:00604292270.020
sequestering of metal ionGO:0051238240.020
blood circulationGO:00080151130.020
Rat
neuron differentiationGO:00301821380.020
peripheral nervous system developmentGO:000742220.020
negative regulation of protein modification processGO:00314002000.020
regulation of cytoplasmic transportGO:19036491490.020
regulation of immune responseGO:00507762010.020
positive regulation of gtp catabolic processGO:00331261660.020
reactive oxygen species biosynthetic processGO:190340940.020
positive regulation of cellular component movementGO:00512721810.019
muscle system processGO:0003012810.019
circulatory system developmentGO:00723592620.019
anatomical structure formation involved in morphogenesisGO:00486462840.019
regulation of sequence specific dna binding transcription factor activityGO:00510902110.019
actin filament based movementGO:0030048170.019
central nervous system developmentGO:00074171230.019
regulation of cyclic nucleotide biosynthetic processGO:0030802490.019
circadian behaviorGO:004851220.019
cellular response to dna damage stimulusGO:00069743790.019
protein targetingGO:00066051870.019
regulation of cell adhesionGO:00301551660.018
positive regulation of cellular component biogenesisGO:00440891580.018
regulation of synaptic plasticityGO:004816730.018
purine containing compound biosynthetic processGO:0072522880.018
response to organonitrogen compoundGO:00102431560.018
anterior posterior axis specificationGO:000994820.018
regulation of multi organism processGO:00439001570.018
cardiac muscle cell contractionGO:008600340.018
positive regulation of organelle organizationGO:00106381950.018
Rat
somatic stem cell maintenanceGO:003501940.018
motor neuron axon guidanceGO:000804520.018
peptidyl tyrosine phosphorylationGO:00181081700.018
embryonic epithelial tube formationGO:000183840.018
chemotaxisGO:00069351570.018
protein ubiquitinationGO:00165673140.018
negative regulation of phosphorylationGO:00423261740.018
endodermal cell fate specificationGO:000171440.018
regulation of transmembrane transportGO:00347621390.018
response to lipidGO:00339932060.018
spermatid differentiationGO:004851540.018
cellular calcium ion homeostasisGO:00068741170.018
endocytosisGO:00068971590.018
nucleocytoplasmic transportGO:00069131760.017
sex determinationGO:000753030.017
negative regulation of cell cycleGO:00457861930.017
Mouse
organ formationGO:004864530.017
proteolysis involved in cellular protein catabolic processGO:00516032440.017
response to axon injuryGO:004867810.017
regulation of neurotransmitter secretionGO:004692830.017
i kappab kinase nf kappab signalingGO:00072491660.017
single organismal cell cell adhesionGO:00163371480.017
endomembrane system organizationGO:00102561960.017
cell activationGO:00017752130.017
cellular response to organic cyclic compoundGO:00714071270.017
regulation of actin filament based processGO:00329701410.017
endodermal cell fate commitmentGO:000171140.017
immune system developmentGO:00025201950.017
organ morphogenesisGO:00098871470.017
regulation of ion homeostasisGO:2000021730.017
positive regulation of cell differentiationGO:00455972110.017
Mouse
cellular protein catabolic processGO:00442572610.017
posttranscriptional regulation of gene expressionGO:00106082130.017
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.017
neuron fate commitmentGO:004866320.017
nuclear transportGO:00511691790.017
cellular protein complex assemblyGO:00436231880.017
regulation of neural precursor cell proliferationGO:200017740.017
morphogenesis of embryonic epitheliumGO:001633140.017
regulation of behaviorGO:0050795820.017
reactive nitrogen species metabolic processGO:200105730.017
carboxylic acid biosynthetic processGO:0046394970.017
protein modification by small protein conjugationGO:00324463420.016
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188430.016
defense response to other organismGO:00985421290.016
growthGO:00400072020.016
spermatid developmentGO:000728640.016
cellular response to hormone stimulusGO:00328701250.016
matingGO:000761810.016
negative regulation of gliogenesisGO:001401430.016
behaviorGO:00076101120.016
regulation of actin cytoskeleton organizationGO:00329561160.016
positive regulation of intracellular transportGO:00323881040.016
sensory perception of painGO:001923340.016
single organism cell adhesionGO:00986021790.016
positive regulation of proteolysisGO:00458621420.016
Rat
sequestering of calcium ionGO:0051208170.016
head developmentGO:00603221080.016
regulation of reactive oxygen species biosynthetic processGO:190342630.016
positive regulation of purine nucleotide biosynthetic processGO:1900373380.016
positive regulation of immune responseGO:00507781590.016
cellular response to lipidGO:00713961270.016
regulation of mitotic cell cycleGO:00073461890.016
interspecies interaction between organismsGO:00444191560.016
regulation of ras gtpase activityGO:00323181280.016
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.016
associative learningGO:000830610.016
regulation of protein catabolic processGO:00421761550.016
glial cell migrationGO:000834740.016
epithelial cell proliferationGO:00506731280.016
monovalent inorganic cation transportGO:00156721280.016
establishment of protein localization to organelleGO:00725941720.016
multicellular organismal response to stressGO:003355510.016
regulation of cell projection organizationGO:00313441070.016
cell substrate adhesionGO:00315891320.016
organic anion transportGO:00157111030.016
actin mediated cell contractionGO:0070252120.015
regulation of epithelial cell proliferationGO:00506781130.015
regulation of ras protein signal transductionGO:00465781550.015
microtubule based processGO:00070172100.015
cardiac cell fate determinationGO:006091330.015
negative regulation of protein phosphorylationGO:00019331400.015
anterior posterior axis specification embryoGO:000859520.015
brain developmentGO:0007420970.015
epithelial cell differentiationGO:00308551410.015
regulation of system processGO:00440571010.015
muscle contractionGO:0006936730.015
oocyte differentiationGO:000999420.015
response to bacteriumGO:00096171440.015
positive regulation of ras gtpase activityGO:00323201170.015
regulation of membrane potentialGO:0042391950.015
spinal cord developmentGO:002151040.015
regulation of protein maturationGO:19033171500.015
regulation of camp metabolic processGO:0030814520.015
glycoprotein metabolic processGO:00091001100.015
receptor metabolic processGO:0043112810.015
photoreceptor cell differentiationGO:004653020.015
cellular response to nitrogen compoundGO:19016991440.015
hemopoiesisGO:00300971800.015
regulation of i kappab kinase nf kappab signalingGO:00431221620.015
oocyte developmentGO:004859910.015
erk1 and erk2 cascadeGO:00703711040.015
metencephalon developmentGO:002203720.015
hormone metabolic processGO:0042445610.015
symbiosis encompassing mutualism through parasitismGO:00444031560.015
neuroblast proliferationGO:000740540.015
taxisGO:00423301570.015
negative regulation of cell growthGO:0030308830.015
negative regulation of growthGO:0045926970.015
negative regulation of organelle organizationGO:00106391260.015
specification of organ identityGO:001009230.015
tripartite regional subdivisionGO:000735120.015
nucleoside monophosphate metabolic processGO:00091231910.015
positive regulation of reactive oxygen species metabolic processGO:2000379240.014
regulation of protein processingGO:00706131500.014
negative regulation of transferase activityGO:00513481240.014
lipid catabolic processGO:0016042840.014
actin filament organizationGO:00070151280.014
protein localization to membraneGO:00726571600.014
modification dependent macromolecule catabolic processGO:00436322120.014
astrocyte differentiationGO:004870840.014
cell projection assemblyGO:00300311260.014
regulation of peptidase activityGO:00525471800.014
Rat
nerve developmentGO:002167540.014
negative regulation of cell differentiationGO:00455961710.014
Mouse
cell divisionGO:00513011680.014
alcohol metabolic processGO:00060661140.014
vasculature developmentGO:00019441810.014
cellular carbohydrate metabolic processGO:0044262840.014
neural tube formationGO:000184130.014
purine ribonucleoside monophosphate metabolic processGO:00091671860.014
neuron developmentGO:00486661130.014
cell cycle phase transitionGO:00447701730.014
wnt signaling pathwayGO:00160551560.014
regulation of nervous system developmentGO:0051960880.014
Mouse
multi organism cellular processGO:00447641560.014
regulation of nucleotide biosynthetic processGO:0030808500.014
regulation of camp biosynthetic processGO:0030817450.014
regulation of dna metabolic processGO:00510521530.014
Rat
cytosolic calcium ion homeostasisGO:0051480890.014
neuron projection developmentGO:00311751060.014
regulation of endopeptidase activityGO:00525481700.014
Rat
response to activityGO:001482300.014
positive regulation of cell developmentGO:0010720920.014
Mouse
response to radiationGO:00093141510.014
proteasomal protein catabolic processGO:00104981760.013
cd8 positive alpha beta t cell activationGO:003603730.013
defense response to fungusGO:005083240.013
protein importGO:00170381300.013
response to inorganic substanceGO:00100351270.013
compound eye developmentGO:004874910.013
regulation of axon guidanceGO:190266730.013
regulation of vesicle mediated transportGO:00606271300.013
regulation of intracellular protein transportGO:00331571230.013
positive regulation of reactive oxygen species biosynthetic processGO:190342820.013
regulation of map kinase activityGO:00434051080.013
positive regulation of neural precursor cell proliferationGO:200017920.013
activation of protein kinase activityGO:0032147900.013
intrinsic apoptotic signaling pathwayGO:00971931270.013
hematopoietic or lymphoid organ developmentGO:00485341860.013
regulation of branching involved in ureteric bud morphogenesisGO:009018930.013
signal releaseGO:0023061700.013
Mouse
cellular modified amino acid metabolic processGO:0006575640.013
glycerolipid metabolic processGO:00464861070.013
cell part morphogenesisGO:00329901370.013
chromatin modificationGO:00165682980.013
embryonic forelimb morphogenesisGO:003511540.013
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.013
ubiquitin dependent protein catabolic processGO:00065112060.013
phospholipid metabolic processGO:0006644990.013
hindlimb morphogenesisGO:003513720.013
regulation of peptidyl tyrosine phosphorylationGO:00507301080.013
response to oxygen levelsGO:00704821000.013
chromatin organizationGO:00063253510.013
cellular response to organonitrogen compoundGO:00714171240.013
modification dependent protein catabolic processGO:00199412090.013
response to drugGO:0042493810.013
purine nucleoside monophosphate metabolic processGO:00091261860.013
monocarboxylic acid biosynthetic processGO:0072330670.013
negative regulation of immune system processGO:00026831360.013
viral processGO:00160321460.013
blood vessel morphogenesisGO:00485141620.013
regulation of cysteine type endopeptidase activityGO:20001161270.013
Rat
response to virusGO:00096151260.013
response to oxidative stressGO:00069791210.013

GPER disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.047
sensory system diseaseDOID:00501552030.032
nervous system diseaseDOID:8634310.032
inherited metabolic disorderDOID:6552420.031
musculoskeletal system diseaseDOID:172230.029
eye and adnexa diseaseDOID:14921500.026
eye diseaseDOID:56141490.024
retinal diseaseDOID:56791180.020
central nervous system diseaseDOID:3311860.019
connective tissue diseaseDOID:651090.019
disease of cellular proliferationDOID:145661740.019
cancerDOID:1621670.018
organ system cancerDOID:00506861640.018
cardiovascular system diseaseDOID:12871060.017
immune system diseaseDOID:29141550.015
bone diseaseDOID:0080001880.013