Homo sapiens

60 known processes

PNPLA2

patatin-like phospholipase domain containing 2

(Aliases: 1110001C14Rik,DKFZp667M109,PEDF-R,ATGL,TTS-2.2,TTS2)

PNPLA2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
lipid metabolic processGO:00066293810.373
lipid biosynthetic processGO:00086101770.257
Human
purine nucleoside catabolic processGO:00061523980.214
cellular lipid metabolic processGO:00442553030.214
purine containing compound catabolic processGO:00725234110.192
purine nucleoside triphosphate metabolic processGO:00091444120.175
positive regulation of purine nucleotide metabolic processGO:19005442270.163
small gtpase mediated signal transductionGO:0007264780.141
response to oxygen containing compoundGO:19017003690.136
cellular macromolecule catabolic processGO:00442653800.129
positive regulation of cellular catabolic processGO:00313312840.127
glycerolipid metabolic processGO:00464861070.120
ribonucleotide catabolic processGO:00092614050.115
protein catabolic processGO:00301633250.111
guanosine containing compound metabolic processGO:19010682440.106
negative regulation of camp mediated signalingGO:004395140.100
purine ribonucleoside catabolic processGO:00461303980.097
purine nucleotide catabolic processGO:00061954050.096
cytokine productionGO:00018162470.093
regulation of cytokine productionGO:00018172320.091
regulation of purine nucleotide catabolic processGO:00331212050.087
nucleoside catabolic processGO:00091644080.085
purine nucleoside triphosphate catabolic processGO:00091463920.082
positive regulation of nucleotide catabolic processGO:00308131850.079
nucleotide catabolic processGO:00091664080.078
lipid catabolic processGO:0016042840.078
cellular ketone metabolic processGO:0042180800.075
nucleoside phosphate catabolic processGO:19012924120.075
regulation of nucleoside metabolic processGO:00091182090.074
signal transduction by phosphorylationGO:00230142970.073
cellular response to endogenous stimulusGO:00714953360.073
carbohydrate metabolic processGO:00059752070.072
ribonucleoside triphosphate metabolic processGO:00091994120.072
ribonucleoside catabolic processGO:00424544060.071
negative regulation of intracellular signal transductionGO:19025321830.070
regulation of ras gtpase activityGO:00323181280.070
nucleoside triphosphate metabolic processGO:00091414220.067
positive regulation of gtpase activityGO:00435471660.066
positive regulation of nucleotide metabolic processGO:00459812300.065
negative regulation of multicellular organismal processGO:00512413170.065
guanosine containing compound catabolic processGO:19010692390.064
positive regulation of gtp catabolic processGO:00331261660.064
purine ribonucleoside metabolic processGO:00461284370.064
cellular response to oxygen containing compoundGO:19017012760.063
positive regulation of purine nucleotide catabolic processGO:00331231850.062
endomembrane system organizationGO:00102561960.061
regulation of mapk cascadeGO:00434082620.061
system processGO:00030083490.060
regulation of gtp catabolic processGO:00331241800.060
cellular protein catabolic processGO:00442572610.060
organonitrogen compound biosynthetic processGO:19015662000.059
glycosyl compound catabolic processGO:19016584130.058
ras protein signal transductionGO:0007265730.057
fatty acid metabolic processGO:00066311150.056
purine ribonucleoside triphosphate metabolic processGO:00092054110.055
purine ribonucleotide catabolic processGO:00091544040.055
phospholipid metabolic processGO:0006644990.054
organophosphate catabolic processGO:00464344300.054
protein ubiquitinationGO:00165673140.054
cation transportGO:00068123310.053
ribonucleoside triphosphate catabolic processGO:00092033910.052
circulatory system developmentGO:00723592620.051
organophosphate biosynthetic processGO:00904071630.051
regulation of kinase activityGO:00435493140.050
small molecule biosynthetic processGO:00442831570.050
mapk cascadeGO:00001652880.049
negative regulation of transportGO:00510511760.049
enzyme linked receptor protein signaling pathwayGO:00071673030.049
single organism cellular localizationGO:19025803320.047
regulation of transferase activityGO:00513383550.046
monocarboxylic acid metabolic processGO:00327871850.046
oxidation reduction processGO:00551143960.045
protein modification by small protein conjugationGO:00324463420.045
carboxylic acid catabolic processGO:0046395710.045
multicellular organismal agingGO:001025930.045
gtp catabolic processGO:00061842370.044
negative regulation of developmental processGO:00510932470.044
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.043
cellular component morphogenesisGO:00329893140.043
small molecule catabolic processGO:0044282920.043
negative regulation of cellular protein metabolic processGO:00322693530.042
regulation of small gtpase mediated signal transductionGO:00510561560.042
regulation of cellular ketone metabolic processGO:0010565500.042
gtp metabolic processGO:00460392390.042
metal ion transportGO:00300012720.042
segmentationGO:003528240.041
nucleoside triphosphate catabolic processGO:00091433940.041
response to nitrogen compoundGO:19016981840.040
response to hormoneGO:00097251750.040
regulation of nucleotide catabolic processGO:00308112050.039
cardiovascular system developmentGO:00723582620.039
cellular carbohydrate metabolic processGO:0044262840.039
regulation of intracellular transportGO:00323861950.039
organic acid catabolic processGO:0016054710.039
negative regulation of cellular component organizationGO:00511292350.039
amine metabolic processGO:0009308440.038
positive regulation of apoptotic processGO:00430652460.038
female gamete generationGO:000729220.038
cellular lipid catabolic processGO:0044242650.037
regulation of cellular component movementGO:00512703340.037
vesicle mediated transportGO:00161923710.037
determination of adult lifespanGO:000834020.037
negative regulation of catalytic activityGO:00430863350.037
mitochondrion organizationGO:00070051560.036
cellular amino acid metabolic processGO:00065201160.036
positive regulation of cell deathGO:00109422630.036
negative regulation of phosphate metabolic processGO:00459362670.036
regulation of cellular component biogenesisGO:00440872810.036
cellular amine metabolic processGO:0044106410.035
oogenesisGO:004847720.035
positive regulation of cellular amine metabolic processGO:003324070.035
purine ribonucleoside triphosphate catabolic processGO:00092073910.034
regulation of protein kinase activityGO:00458592890.034
positive regulation of hydrolase activityGO:00513453310.034
negative regulation of protein metabolic processGO:00512483910.034
single organism carbohydrate metabolic processGO:00447231930.034
epithelium developmentGO:00604292270.034
positive regulation of cytokine productionGO:00018191670.033
cellular response to nitrogen compoundGO:19016991440.033
rho protein signal transductionGO:0007266260.033
regulation of ras protein signal transductionGO:00465781550.033
intracellular receptor signaling pathwayGO:00305221040.033
purine ribonucleoside monophosphate metabolic processGO:00091671860.033
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.033
modification dependent macromolecule catabolic processGO:00436322120.032
chemical homeostasisGO:00488783060.031
positive regulation of protein phosphorylationGO:00019343130.031
post embryonic developmentGO:000979120.030
proteasomal protein catabolic processGO:00104981760.030
response to biotic stimulusGO:00096072760.030
regulation of cellular amino acid metabolic processGO:000652160.030
biological adhesionGO:00226103310.029
regulation of protein catabolic processGO:00421761550.029
regulation of nucleotide metabolic processGO:00061402690.029
carboxylic acid biosynthetic processGO:0046394970.029
nucleoside monophosphate metabolic processGO:00091231910.029
response to external biotic stimulusGO:00432072610.029
apoptotic signaling pathwayGO:00971902680.028
regulation of protein localizationGO:00328802960.028
cell morphogenesisGO:00009022960.028
cellular homeostasisGO:00197251960.027
regulation of purine nucleotide metabolic processGO:19005422640.027
receptor metabolic processGO:0043112810.027
positive regulation of transferase activityGO:00513472270.027
phospholipid biosynthetic processGO:0008654440.027
negative regulation of lipid metabolic processGO:0045833380.026
peptidyl serine phosphorylationGO:00181051010.026
positive regulation of transportGO:00510503360.026
response to organic cyclic compoundGO:00140702040.026
glycerophospholipid metabolic processGO:0006650840.026
cell fate determinationGO:000170930.026
positive regulation of kinase activityGO:00336742040.026
cellular response to hormone stimulusGO:00328701250.026
protein processingGO:00164852260.026
response to growth factorGO:00708482050.026
cell developmentGO:00484683280.026
microtubule based processGO:00070172100.025
regulation of cell migrationGO:00303342890.025
secretionGO:00469032540.025
modification dependent protein catabolic processGO:00199412090.024
monocarboxylic acid catabolic processGO:0072329370.024
regulation of gtpase activityGO:00430871800.024
transmembrane transportGO:00550853990.024
positive regulation of protein kinase activityGO:00458601900.024
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.024
cell adhesionGO:00071553250.024
response to other organismGO:00517072610.024
blood circulationGO:00080151130.024
proteolysis involved in cellular protein catabolic processGO:00516032440.024
negative regulation of cell deathGO:00605483450.023
positive regulation of phosphorylationGO:00423273940.023
endocytosisGO:00068971590.023
ubiquitin dependent protein catabolic processGO:00065112060.023
regulation of protein serine threonine kinase activityGO:00719001790.023
response to woundingGO:00096111680.023
organic anion transportGO:00157111030.022
wound healingGO:00420601150.022
negative regulation of programmed cell deathGO:00430693210.022
hematopoietic or lymphoid organ developmentGO:00485341860.022
anion transportGO:00068201610.022
regulation of i kappab kinase nf kappab signalingGO:00431221620.022
lipid localizationGO:00108761060.022
negative regulation of apoptotic processGO:00430663160.022
single organism membrane organizationGO:00448022680.022
regulation of cellular response to stressGO:00801352440.021
i kappab kinase nf kappab signalingGO:00072491660.021
stress activated mapk cascadeGO:0051403930.021
positive regulation of nucleoside metabolic processGO:00459791860.021
negative regulation of catabolic processGO:00098951040.021
regulation of proteolysisGO:00301622930.021
cellular response to growth factor stimulusGO:00713631970.021
regulation of cell differentiationGO:00455953930.021
ribonucleoside monophosphate metabolic processGO:00091611870.021
positive regulation of stress activated mapk cascadeGO:0032874600.021
plasma membrane organizationGO:00070091150.021
nucleoside monophosphate catabolic processGO:00091251590.021
symbiosis encompassing mutualism through parasitismGO:00444031560.021
regulation of cell motilityGO:20001452990.020
response to abiotic stimulusGO:00096283360.020
interspecies interaction between organismsGO:00444191560.020
organic hydroxy compound metabolic processGO:19016151470.020
negative regulation of phosphorus metabolic processGO:00105632670.020
atp metabolic processGO:00460341760.020
intrinsic apoptotic signaling pathwayGO:00971931270.020
epithelial cell migrationGO:00106311190.020
sulfur compound metabolic processGO:00067901010.020
negative regulation of cell differentiationGO:00455961710.020
immune system developmentGO:00025201950.020
secretion by cellGO:00329402260.019
maintenance of locationGO:00512351120.019
ion transmembrane transportGO:00342203380.019
cell growthGO:00160491600.019
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.019
organic acid biosynthetic processGO:0016053970.019
negative regulation of phosphorylationGO:00423261740.019
negative regulation of organelle organizationGO:00106391260.019
dephosphorylationGO:00163112090.019
regulation of cellular component sizeGO:0032535820.019
regulation of sequence specific dna binding transcription factor activityGO:00510902110.019
membrane organizationGO:00610242920.018
lipid transportGO:0006869900.018
positive regulation of programmed cell deathGO:00430682490.018
cytokine mediated signaling pathwayGO:00192211090.018
regulation of establishment of protein localizationGO:00702012420.018
purine nucleoside monophosphate catabolic processGO:00091281580.018
positive regulation of developmental processGO:00510943140.018
regulation of intracellular protein transportGO:00331571230.018
heart developmentGO:0007507950.018
regulation of jnk cascadeGO:0046328730.018
nitrogen compound transportGO:00717051910.018
defense responseGO:00069523150.018
multi organism cellular processGO:00447641560.018
striated muscle contractionGO:0006941520.017
carbohydrate derivative biosynthetic processGO:19011372070.017
regulation of cellular amine metabolic processGO:0033238110.017
regulation of locomotionGO:00400123290.017
posttranscriptional regulation of gene expressionGO:00106082130.017
embryonic placenta developmentGO:000189210.017
neurological system processGO:00508771630.017
glycerolipid biosynthetic processGO:0045017510.017
Human
gland developmentGO:0048732480.017
ribonucleoside monophosphate catabolic processGO:00091581580.017
ion homeostasisGO:00508012300.017
regulation of defense responseGO:00313471540.017
syncytium formation by plasma membrane fusionGO:000076820.017
protein localization to plasma membraneGO:0072659930.017
regulation of stress activated mapk cascadeGO:0032872840.017
cytoplasmic transportGO:00164823790.017
generation of precursor metabolites and energyGO:0006091680.017
regulation of stress activated protein kinase signaling cascadeGO:0070302850.017
fatty acid biosynthetic processGO:0006633460.016
protein targetingGO:00066051870.016
divalent inorganic cation transportGO:00725111580.016
regulation of body fluid levelsGO:0050878990.016
positive regulation of cellular component movementGO:00512721810.016
embryo developmentGO:00097901230.016
negative regulation of protein modification processGO:00314002000.016
viral processGO:00160321460.016
neuromuscular junction developmentGO:000752830.016
negative regulation of growthGO:0045926970.016
nervous system developmentGO:00073992930.016
response to peptideGO:1901652650.016
negative regulation of cellular amine metabolic processGO:003323930.016
negative regulation of cellular catabolic processGO:0031330830.016
immune responseGO:00069553070.015
cellular response to peptide hormone stimulusGO:0071375560.015
organelle fissionGO:00482851490.015
response to oxidative stressGO:00069791210.015
negative regulation of kinase activityGO:00336731060.015
carbohydrate biosynthetic processGO:0016051420.015
monocarboxylic acid biosynthetic processGO:0072330670.015
protein k48 linked ubiquitinationGO:0070936380.015
regulation of anatomical structure morphogenesisGO:00226032860.015
cell cell junction organizationGO:0045216690.015
regulation of endothelial cell migrationGO:0010594670.015
cellular calcium ion homeostasisGO:00068741170.015
negative regulation of protein maturationGO:19033181420.015
positive regulation of catabolic processGO:00098963100.015
positive regulation of cell proliferationGO:00082843010.015
sodium ion transportGO:0006814610.015
second messenger mediated signalingGO:0019932780.015
divalent metal ion transportGO:00708381520.015
cellular response to organonitrogen compoundGO:00714171240.015
negative regulation of protein kinase activityGO:0006469980.015
tube developmentGO:00352951250.014
spermatid differentiationGO:004851540.014
jnk cascadeGO:0007254800.014
purine nucleoside monophosphate metabolic processGO:00091261860.014
negative regulation of proteolysisGO:00458611320.014
cyclic nucleotide biosynthetic processGO:0009190610.014
positive regulation of cellular component organizationGO:00511303760.014
calcium ion transportGO:00068161470.014
memoryGO:000761330.014
negative regulation of mapk cascadeGO:0043409560.014
response to peptide hormoneGO:0043434610.014
anterior posterior axis specification embryoGO:000859520.014
regulation of lipid biosynthetic processGO:0046890470.014
developmental programmed cell deathGO:001062330.014
negative regulation of transferase activityGO:00513481240.014
regulation of rho protein signal transductionGO:0035023790.014
stress activated protein kinase signaling cascadeGO:0031098940.014
camp biosynthetic processGO:0006171470.014
negative regulation of peptidase activityGO:0010466910.014
regulation of camp mediated signalingGO:0043949130.014
cellular response to cytokine stimulusGO:00713451810.014
protein targeting to nucleusGO:00447441040.014
atp catabolic processGO:00062001570.014
protein dephosphorylationGO:0006470810.014
regulation of cell cycleGO:00517263930.014
growthGO:00400072020.014
polysaccharide metabolic processGO:0005976330.014
lipid modificationGO:0030258840.014
organ formationGO:004864530.014
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.014
mitotic cell cycle processGO:19030472860.014
negative regulation of hydrolase activityGO:00513461820.014
compound eye developmentGO:004874910.014
negative regulation of protein serine threonine kinase activityGO:0071901570.014
regulation of map kinase activityGO:00434051080.014
cellular chemical homeostasisGO:00550821800.013
glycoprotein metabolic processGO:00091001100.013
positive regulation of lipid metabolic processGO:0045834500.013
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090100410.013
negative regulation of protein phosphorylationGO:00019331400.013
protein maturationGO:00516042330.013
cellular polysaccharide metabolic processGO:0044264270.013
epithelium migrationGO:00901321190.013
regulation of reactive oxygen species metabolic processGO:2000377410.013
negative regulation of protein transportGO:0051224750.013
cellular response to peptideGO:1901653590.013
reactive oxygen species metabolic processGO:0072593750.013
positive regulation of cellular amino acid metabolic processGO:004576430.013
dermatan sulfate metabolic processGO:003020530.013
glycerophospholipid biosynthetic processGO:0046474400.013
hemopoiesisGO:00300971800.013
positive regulation of cell migrationGO:00303351720.013
negative regulation of protein processingGO:00109551420.013
regulation of cytoplasmic transportGO:19036491490.013
response to organonitrogen compoundGO:00102431560.013
purine ribonucleoside monophosphate catabolic processGO:00091691580.013
autophagyGO:0006914880.013
regenerationGO:003109940.012
inorganic ion transmembrane transportGO:00986602310.012
epithelial cell differentiationGO:00308551410.012
response to insulinGO:0032868450.012
nuclear transportGO:00511691790.012
positive regulation of vascular endothelial growth factor signaling pathwayGO:190074830.012
oocyte developmentGO:004859910.012
protein secretionGO:0009306980.012
positive regulation of protein serine threonine kinase activityGO:00719021190.012
protein autophosphorylationGO:00467771230.012
cellular response to organic cyclic compoundGO:00714071270.012
response to lipidGO:00339932060.012
regulation of actin cytoskeleton organizationGO:00329561160.012
regulation of response to external stimulusGO:00321012220.012
monosaccharide metabolic processGO:0005996740.012
regulation of cellular protein catabolic processGO:1903362960.012
regulation of cell growthGO:00015581350.012
intracellular protein transportGO:00068862700.012
cell junction assemblyGO:0034329670.012
regulation of protein targetingGO:1903533910.012
positive regulation of cell differentiationGO:00455972110.012
protein acylationGO:00435431380.012
protein localization to membraneGO:00726571600.012
anterior posterior axis specificationGO:000994820.012
positive regulation of ras gtpase activityGO:00323201170.012
organelle assemblyGO:00709251760.012
regulation of lipid metabolic processGO:0019216960.012
positive regulation of locomotionGO:00400171860.012
regulation of carbohydrate metabolic processGO:0006109540.012
regulation of nervous system developmentGO:0051960880.012
single organismal cell cell adhesionGO:00163371480.012
regulation of cell adhesionGO:00301551660.012
regulation of cell cycle processGO:00105642660.011
sensory perceptionGO:00076001030.011
regulation of cellular carbohydrate metabolic processGO:0010675470.011
negative regulation of cell growthGO:0030308830.011
divalent inorganic cation homeostasisGO:00725071360.011
regulation of ion transportGO:00432691890.011
positive regulation of cell cycle processGO:00900681060.011
stem cell divisionGO:001714520.011
regulation of cyclic nucleotide metabolic processGO:0030799630.011
regulation of protein transportGO:00512232130.011
tube closureGO:006060630.011
blastoderm segmentationGO:000735020.011
regulation of peptidase activityGO:00525471800.011
regulation of cellular response to growth factor stimulusGO:0090287760.011
positive regulation of defense responseGO:0031349870.011
long chain fatty acid metabolic processGO:0001676300.011
covalent chromatin modificationGO:00165692540.011
muscle contractionGO:0006936730.011
reactive oxygen species biosynthetic processGO:190340940.011
regulation of bmp signaling pathwayGO:0030510270.011
positive regulation of cell cycleGO:00457871400.011
positive regulation of reactive oxygen species metabolic processGO:2000379240.011
bmp signaling pathwayGO:0030509490.011
cation homeostasisGO:00550801890.011
chromatin organizationGO:00063253510.011
negative regulation of protein complex assemblyGO:0031333430.011
single organism nuclear importGO:19025931040.011
cellular response to dna damage stimulusGO:00069743790.011
cellular cation homeostasisGO:00300031630.011
protein importGO:00170381300.011
positive regulation of cell motilityGO:20001471770.011
neuroblast divisionGO:005505710.011
positive regulation of camp metabolic processGO:0030816410.011
histone modificationGO:00165702510.011
myeloid cell differentiationGO:00300991170.010
regulation of mitotic cell cycleGO:00073461890.010
muscle system processGO:0003012810.010
aminoglycan metabolic processGO:0006022390.010
positive regulation of rab gtpase activityGO:0032851390.010
regulation of immune responseGO:00507762010.010
neurogenesisGO:00220081690.010
regulation of mitochondrion organizationGO:0010821540.010
t cell differentiation in thymusGO:003307740.010
cell activationGO:00017752130.010
carboxylic acid transportGO:0046942630.010
energy derivation by oxidation of organic compoundsGO:0015980430.010
calcium ion homeostasisGO:00550741220.010
meiotic chromosome segregationGO:004513240.010
cell substrate adhesionGO:00315891320.010
nuclear importGO:00511701060.010
rab protein signal transductionGO:003248240.010
transforming growth factor beta receptor signaling pathwayGO:0007179760.010

PNPLA2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.043
musculoskeletal system diseaseDOID:172230.039
urinary system diseaseDOID:18400.027
neuropathyDOID:870520.025
nervous system diseaseDOID:8634310.025
inherited metabolic disorderDOID:6552420.024
immune system diseaseDOID:29141550.022
kidney diseaseDOID:557360.017
central nervous system diseaseDOID:3311860.017
muscular diseaseDOID:00800001140.017
cardiovascular system diseaseDOID:12871060.016
muscle tissue diseaseDOID:661130.012
neurodegenerative diseaseDOID:12891020.011