Homo sapiens

207 known processes

PPM1A

protein phosphatase, Mg2+/Mn2+ dependent, 1A

(Aliases: PP2C-ALPHA,PP2Calpha,PP2CA,MGC9201,FLJ42306)

PPM1A biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
wnt signaling pathwayGO:00160551560.411
regulation of wnt signaling pathwayGO:00301111230.269
nucleocytoplasmic transportGO:00069131760.242
cellular macromolecule catabolic processGO:00442653800.227
negative regulation of protein metabolic processGO:00512483910.195
Fly
negative regulation of programmed cell deathGO:00430693210.188
post embryonic developmentGO:000979120.187
Fly
small gtpase mediated signal transductionGO:0007264780.153
Fly
multicellular organismal agingGO:001025930.143
Fly
modification dependent macromolecule catabolic processGO:00436322120.130
regulation of protein localizationGO:00328802960.127
locomotory behaviorGO:000762610.123
protein catabolic processGO:00301633250.119
ras protein signal transductionGO:0007265730.114
Fly
proteasomal protein catabolic processGO:00104981760.110
mapk cascadeGO:00001652880.107
Fly
negative regulation of cell deathGO:00605483450.107
regulation of intracellular transportGO:00323861950.107
cytoplasmic transportGO:00164823790.101
cellular response to endogenous stimulusGO:00714953360.093
modification dependent protein catabolic processGO:00199412090.088
cellular protein catabolic processGO:00442572610.087
regulation of cellular response to stressGO:00801352440.085
Fly
intracellular protein transportGO:00068862700.085
regulation of cell cycleGO:00517263930.084
nuclear exportGO:0051168690.081
protein ubiquitinationGO:00165673140.078
negative regulation of apoptotic processGO:00430663160.078
response to oxygen containing compoundGO:19017003690.077
apoptotic signaling pathwayGO:00971902680.074
positive regulation of catabolic processGO:00098963100.074
protein localization to organelleGO:00333652800.071
determination of adult lifespanGO:000834020.070
Fly
negative regulation of cellular protein metabolic processGO:00322693530.069
Fly
gtp catabolic processGO:00061842370.068
protein modification by small protein conjugationGO:00324463420.068
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.068
cellular response to dna damage stimulusGO:00069743790.067
regulation of intracellular protein transportGO:00331571230.066
posttranscriptional regulation of gene expressionGO:00106082130.066
protein export from nucleusGO:0006611290.065
negative regulation of apoptotic signaling pathwayGO:2001234970.064
cellular component morphogenesisGO:00329893140.063
regulation of nucleocytoplasmic transportGO:0046822980.060
proteolysis involved in cellular protein catabolic processGO:00516032440.059
ubiquitin dependent protein catabolic processGO:00065112060.059
negative regulation of phosphate metabolic processGO:00459362670.059
Fly
positive regulation of cell deathGO:00109422630.059
positive regulation of purine nucleotide metabolic processGO:19005442270.058
nucleoside triphosphate metabolic processGO:00091414220.058
negative regulation of protein transportGO:0051224750.057
response to oxidative stressGO:00069791210.057
Fly
response to abiotic stimulusGO:00096283360.056
Fly
cellular response to oxygen containing compoundGO:19017012760.056
regulation of protein localization to nucleusGO:1900180850.055
regulation of establishment of protein localizationGO:00702012420.054
cell morphogenesisGO:00009022960.054
signal transduction by phosphorylationGO:00230142970.054
Fly
gtp metabolic processGO:00460392390.052
female gamete generationGO:000729220.049
regulation of proteolysisGO:00301622930.049
purine ribonucleoside triphosphate catabolic processGO:00092073910.048
negative regulation of protein phosphorylationGO:00019331400.048
Fly
purine ribonucleotide catabolic processGO:00091544040.048
regulation of protein kinase activityGO:00458592890.047
Fly
cellular macromolecular complex assemblyGO:00346223240.047
nuclear transportGO:00511691790.047
oogenesisGO:004847720.047
defense responseGO:00069523150.047
Human
regulation of cell cycle processGO:00105642660.045
mitotic cell cycleGO:00002783260.045
Fly
regulation of protein serine threonine kinase activityGO:00719001790.044
Fly
regulation of protein import into nucleusGO:0042306780.044
purine ribonucleoside catabolic processGO:00461303980.043
guanosine containing compound catabolic processGO:19010692390.043
negative regulation of wnt signaling pathwayGO:0030178690.043
glycosyl compound catabolic processGO:19016584130.042
regulation of dna metabolic processGO:00510521530.042
regulation of purine nucleotide metabolic processGO:19005422640.042
regulation of small gtpase mediated signal transductionGO:00510561560.041
Fly
hindbrain developmentGO:003090230.041
endosomal transportGO:00161971290.040
jnk cascadeGO:0007254800.040
Fly
transforming growth factor beta receptor signaling pathwayGO:0007179760.040
guanosine containing compound metabolic processGO:19010682440.040
adult locomotory behaviorGO:000834410.040
dna repairGO:00062811980.040
positive regulation of organelle organizationGO:00106381950.039
negative regulation of phosphorus metabolic processGO:00105632670.039
Fly
regulation of apoptotic signaling pathwayGO:20012331750.039
negative regulation of catalytic activityGO:00430863350.038
Fly
regulation of gtpase activityGO:00430871800.038
response to growth factorGO:00708482050.038
single organism carbohydrate metabolic processGO:00447231930.038
ribonucleoside triphosphate metabolic processGO:00091994120.037
regulation of mapk cascadeGO:00434082620.037
Fly
response to radiationGO:00093141510.037
Fly
positive regulation of nucleotide metabolic processGO:00459812300.037
positive regulation of nucleoside metabolic processGO:00459791860.036
negative regulation of protein modification processGO:00314002000.036
Fly
system processGO:00030083490.036
negative regulation of multicellular organismal processGO:00512413170.036
Human
positive regulation of nucleotide catabolic processGO:00308131850.035
response to hormoneGO:00097251750.035
ribonucleoside catabolic processGO:00424544060.035
response to nitrogen compoundGO:19016981840.035
positive regulation of purine nucleotide catabolic processGO:00331231850.035
purine nucleoside triphosphate metabolic processGO:00091444120.035
chemical homeostasisGO:00488783060.035
chromatin organizationGO:00063253510.035
negative regulation of kinase activityGO:00336731060.035
Fly
regulation of response to dna damage stimulusGO:2001020940.034
carbohydrate metabolic processGO:00059752070.034
response to uvGO:0009411730.033
Fly
cellular amino acid metabolic processGO:00065201160.033
purine containing compound catabolic processGO:00725234110.033
regulation of cytoplasmic transportGO:19036491490.033
regulation of anatomical structure morphogenesisGO:00226032860.032
Fly
positive regulation of ras gtpase activityGO:00323201170.032
neurotransmitter secretionGO:000726940.032
purine nucleotide catabolic processGO:00061954050.032
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.032
single organism cellular localizationGO:19025803320.032
positive regulation of programmed cell deathGO:00430682490.031
dephosphorylationGO:00163112090.031
chromatin modificationGO:00165682980.031
neuromuscular junction developmentGO:000752830.031
morphogenesis of embryonic epitheliumGO:001633140.031
Fly
stress activated mapk cascadeGO:0051403930.031
Fly
single organism nuclear importGO:19025931040.031
purine nucleoside triphosphate catabolic processGO:00091463920.031
mitotic cell cycle processGO:19030472860.031
mitotic cell cycle phase transitionGO:00447721620.030
extrinsic apoptotic signaling pathwayGO:00971911190.030
regulation of nucleotide metabolic processGO:00061402690.030
innate immune responseGO:00450871780.030
nucleoside phosphate catabolic processGO:19012924120.030
positive regulation of cellular catabolic processGO:00313312840.030
positive regulation of transportGO:00510503360.030
regulation of multi organism processGO:00439001570.030
Human
regulation of nucleotide catabolic processGO:00308112050.030
positive regulation of gtpase activityGO:00435471660.029
histone modificationGO:00165702510.029
positive regulation of phosphorylationGO:00423273940.029
nucleotide catabolic processGO:00091664080.029
nitrogen compound transportGO:00717051910.029
negative regulation of transportGO:00510511760.028
vesicle mediated transportGO:00161923710.028
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.028
cellular response to hormone stimulusGO:00328701250.028
vacuole organizationGO:0007033440.028
regulation of kinase activityGO:00435493140.028
Fly
negative regulation of phosphorylationGO:00423261740.027
Fly
methylationGO:00322591060.027
regulation of erk1 and erk2 cascadeGO:0070372990.027
Fly
regulation of stress activated mapk cascadeGO:0032872840.027
Fly
erk1 and erk2 cascadeGO:00703711040.027
Fly
dna integrity checkpointGO:0031570710.026
regulation of mitotic cell cycleGO:00073461890.026
protein targeting to nucleusGO:00447441040.026
long term memoryGO:000761620.026
ribonucleotide catabolic processGO:00092614050.026
protein polyubiquitinationGO:00002091100.025
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.025
behaviorGO:00076101120.025
organ morphogenesisGO:00098871470.025
Fly
response to biotic stimulusGO:00096072760.025
Human
carbohydrate derivative biosynthetic processGO:19011372070.024
regulation of purine nucleotide catabolic processGO:00331212050.024
response to other organismGO:00517072610.024
Human
cell fate determinationGO:000170930.024
anatomical structure formation involved in morphogenesisGO:00486462840.024
metal ion transportGO:00300012720.024
regulation of ras gtpase activityGO:00323181280.024
immune responseGO:00069553070.024
negative regulation of cell proliferationGO:00082852280.024
peptidyl serine modificationGO:00182091060.024
nucleoside catabolic processGO:00091644080.024
lipid metabolic processGO:00066293810.023
regulation of cell morphogenesisGO:00226041530.023
negative regulation of protein kinase activityGO:0006469980.023
Fly
positive regulation of protein kinase activityGO:00458601900.023
protein targetingGO:00066051870.023
purine ribonucleoside metabolic processGO:00461284370.023
growthGO:00400072020.023
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.023
nucleoside triphosphate catabolic processGO:00091433940.023
negative regulation of cell cycle processGO:00109481210.023
response to light stimulusGO:0009416870.023
Fly
actin filament based processGO:00300292240.023
response to cytokineGO:00340972320.023
neurological system processGO:00508771630.023
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.022
response to inorganic substanceGO:00100351270.022
regulation of gtp catabolic processGO:00331241800.022
regulation of anatomical structure sizeGO:00900661010.022
neuroblast proliferationGO:000740540.022
positive regulation of proteolysisGO:00458621420.022
rab protein signal transductionGO:003248240.022
positive regulation of transferase activityGO:00513472270.022
cell type specific apoptotic processGO:00972851250.021
cell projection assemblyGO:00300311260.021
positive regulation of kinase activityGO:00336742040.021
cellular protein complex assemblyGO:00436231880.021
regulation of protein catabolic processGO:00421761550.021
organelle assemblyGO:00709251760.021
response to external biotic stimulusGO:00432072610.021
Human
regulation of i kappab kinase nf kappab signalingGO:00431221620.021
embryo developmentGO:00097901230.021
Fly
cell cycle checkpointGO:00000751170.021
regulation of neurotransmitter secretionGO:004692830.020
maintenance of locationGO:00512351120.020
enzyme linked receptor protein signaling pathwayGO:00071673030.020
regulation of locomotionGO:00400123290.020
peptide transportGO:0015833740.020
regulation of cellular component biogenesisGO:00440872810.020
negative regulation of cell growthGO:0030308830.020
negative regulation of multi organism processGO:0043901920.020
Human
positive regulation of protein transportGO:00512221350.020
regulation of transferase activityGO:00513383550.020
Fly
positive regulation of intracellular transportGO:00323881040.020
regulation of vesicle mediated transportGO:00606271300.020
monosaccharide metabolic processGO:0005996740.020
negative regulation of cell cycleGO:00457861930.020
receptor metabolic processGO:0043112810.020
cilium morphogenesisGO:0060271750.019
rho protein signal transductionGO:0007266260.019
regulation of response to external stimulusGO:00321012220.019
Human
cilium organizationGO:0044782680.019
negative regulation of intracellular signal transductionGO:19025321830.019
cellular chemical homeostasisGO:00550821800.019
metencephalon developmentGO:002203720.019
positive regulation of hydrolase activityGO:00513453310.019
positive regulation of apoptotic processGO:00430652460.019
forebrain generation of neuronsGO:002187230.019
cell projection organizationGO:00300302520.018
regulation of cellular response to growth factor stimulusGO:0090287760.018
nervous system developmentGO:00073992930.018
Fly
peptidyl serine phosphorylationGO:00181051010.018
cell activationGO:00017752130.018
cell developmentGO:00484683280.018
Fly
spermatid developmentGO:000728640.018
positive regulation of protein phosphorylationGO:00019343130.018
positive regulation of cellular amine metabolic processGO:003324070.018
taxisGO:00423301570.018
mitochondrion organizationGO:00070051560.018
lysosomal transportGO:0007041330.018
positive regulation of locomotionGO:00400171860.018
positive regulation of cell cycleGO:00457871400.017
memoryGO:000761330.017
regulation of dna repairGO:0006282470.017
regulation of protein maturationGO:19033171500.017
protein maturationGO:00516042330.017
somitogenesisGO:000175620.017
cellular response to abiotic stimulusGO:00712141170.017
regulation of ras protein signal transductionGO:00465781550.017
Fly
positive regulation of cellular component movementGO:00512721810.017
positive regulation of map kinase activityGO:0043406800.017
neural tube formationGO:000184130.017
amine metabolic processGO:0009308440.017
membrane organizationGO:00610242920.017
regulation of stress activated protein kinase signaling cascadeGO:0070302850.017
Fly
endocytosisGO:00068971590.017
protein import into nucleusGO:00066061040.017
positive regulation of gtp catabolic processGO:00331261660.017
regulation of nucleoside metabolic processGO:00091182090.016
positive regulation of immune system processGO:00026842830.016
negative regulation of cytokine productionGO:0001818820.016
Human
covalent chromatin modificationGO:00165692540.016
circulatory system developmentGO:00723592620.016
negative regulation of protein serine threonine kinase activityGO:0071901570.016
Fly
purine ribonucleoside triphosphate metabolic processGO:00092054110.016
ribonucleoside triphosphate catabolic processGO:00092033910.016
negative regulation of cellular response to growth factor stimulusGO:0090288410.016
rna processingGO:00063962550.016
positive regulation of rab gtpase activityGO:0032851390.016
cellular lipid metabolic processGO:00442553030.016
regulation of jnk cascadeGO:0046328730.016
Fly
embryonic epithelial tube formationGO:000183840.016
cell growthGO:00160491600.016
protein k48 linked ubiquitinationGO:0070936380.016
protein dephosphorylationGO:0006470810.015
response to organonitrogen compoundGO:00102431560.015
negative regulation of intracellular transportGO:0032387600.015
head developmentGO:00603221080.015
cell part morphogenesisGO:00329901370.015
regulation of secretionGO:00510461940.015
intrinsic apoptotic signaling pathwayGO:00971931270.015
regulation of protein processingGO:00706131500.015
i kappab kinase nf kappab signalingGO:00072491660.015
endosome to lysosome transportGO:0008333210.015
regulation of proteasomal protein catabolic processGO:0061136870.015
immune effector processGO:00022521590.015
Human
response to organic cyclic compoundGO:00140702040.015
regulation of protein transportGO:00512232130.015
vacuolar transportGO:0007034340.015
reproductive processGO:00224141060.015
negative regulation of transferase activityGO:00513481240.015
Fly
regulation of synaptic plasticityGO:004816730.015
regulation of protein targetingGO:1903533910.015
positive regulation of cellular component organizationGO:00511303760.015
response to transforming growth factor betaGO:0071559940.015
negative regulation of cytoplasmic transportGO:1903650460.014
establishment of organelle localizationGO:0051656590.014
positive regulation of cellular amino acid metabolic processGO:004576430.014
cell cell signalingGO:00072671550.014
nucleotide biosynthetic processGO:00091651090.014
cd4 positive alpha beta t cell differentiation involved in immune responseGO:000229440.014
cell adhesionGO:00071553250.014
negative regulation of cellular component organizationGO:00511292350.014
regulation of nervous system developmentGO:0051960880.014
Fly
purine nucleoside catabolic processGO:00061523980.014
response to metal ionGO:0010038840.014
response to woundingGO:00096111680.014
chemotaxisGO:00069351570.014
negative regulation of response to external stimulusGO:0032102830.014
Human
regulation of cell cycle phase transitionGO:19019871260.014
response to peptide hormoneGO:0043434610.014
protein localization to nucleusGO:00345041360.014
cellular response to cytokine stimulusGO:00713451810.014
secretionGO:00469032540.013
positive regulation of cytoplasmic transportGO:1903651820.013
axis elongationGO:000340140.013
response to steroid hormoneGO:0048545800.013
actin cytoskeleton organizationGO:00300362070.013
establishment of protein localization to organelleGO:00725941720.013
regulation of cell motilityGO:20001452990.013
cellular response to nitrogen compoundGO:19016991440.013
multi organism cellular processGO:00447641560.013
cellular ion homeostasisGO:00068731680.013
stem cell divisionGO:001714520.013
positive regulation of synaptic transmissionGO:005080640.013
regulation of endopeptidase activityGO:00525481700.013
organophosphate catabolic processGO:00464344300.013
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.013
negative regulation of mapk cascadeGO:0043409560.013
Fly
ion homeostasisGO:00508012300.013
regulation of lipid metabolic processGO:0019216960.013
regulation of cellular component sizeGO:0032535820.013
cellular homeostasisGO:00197251960.013
cardiovascular system developmentGO:00723582620.013
protein processingGO:00164852260.012
negative regulation of proteolysisGO:00458611320.012
single organism reproductive processGO:0044702980.012
regulation of protein modification by small protein conjugation or removalGO:19033201070.012
cell projection morphogenesisGO:00488581290.012
regulation of immune responseGO:00507762010.012
regulation of cellular amino acid metabolic processGO:000652160.012
cell cycle phase transitionGO:00447701730.012
positive regulation of protein catabolic processGO:0045732750.012
nucleoside phosphate biosynthetic processGO:19012931090.012
regulation of cellular component movementGO:00512703340.012
cellular response to oxidative stressGO:0034599850.012
cd4 positive alpha beta t cell differentiationGO:004336740.012
cation transportGO:00068123310.012
calcium ion homeostasisGO:00550741220.012
circadian behaviorGO:004851220.012
cerebellum developmentGO:002154920.012
dna replicationGO:00062601160.012
segmentationGO:003528240.012
autophagyGO:0006914880.012
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237520.012
regulation of cellular protein catabolic processGO:1903362960.012
regulation of innate immune responseGO:0045088970.012
positive regulation of cell migrationGO:00303351720.012
single organism membrane organizationGO:00448022680.012
positive regulation of mapk cascadeGO:00434101900.012
stress activated protein kinase signaling cascadeGO:0031098940.012
Fly
positive regulation of protein serine threonine kinase activityGO:00719021190.012
regulation of secretion by cellGO:19035301770.012
regulation of chromosome organizationGO:00330441030.011
establishment of tissue polarityGO:000716430.011
negative regulation of protein localization to nucleusGO:1900181340.011
forebrain neuron developmentGO:002188420.011
cell cell junction organizationGO:0045216690.011
response to peptideGO:1901652650.011
regulation of protein complex assemblyGO:00432541470.011
monovalent inorganic cation transportGO:00156721280.011
regulation of cell developmentGO:00602841610.011
Fly
negative regulation of growthGO:0045926970.011
neural tube closureGO:000184330.011
macroautophagyGO:0016236390.011
response to virusGO:00096151260.011
Human
protein oligomerizationGO:00512591730.011
regulation of cell growthGO:00015581350.011
regulation of feeding behaviorGO:006025930.011
positive regulation of immune responseGO:00507781590.011
regulation of growthGO:00400081650.011
secretion by cellGO:00329402260.011
tube closureGO:006060630.011
negative regulation of mitotic cell cycleGO:00459301020.011
lipid biosynthetic processGO:00086101770.011
protein deubiquitinationGO:0016579790.011
photoreceptor cell differentiationGO:004653020.011
Fly
innate immune response activating signal transductionGO:0002758480.011
sensory perceptionGO:00076001030.011
cation homeostasisGO:00550801890.011
protein importGO:00170381300.011
developmental programmed cell deathGO:001062330.011
morphogenesis of a polarized epitheliumGO:000173830.011
negative regulation of protein import into nucleusGO:0042308300.011
protein stabilizationGO:0050821640.011
positive regulation of wnt signaling pathwayGO:0030177540.011
tube developmentGO:00352951250.011
cilium assemblyGO:0042384630.011
neuron developmentGO:00486661130.011
reactive oxygen species metabolic processGO:0072593750.011
cell divisionGO:00513011680.010
negative regulation of immune system processGO:00026831360.010
Human
positive regulation of cell differentiationGO:00455972110.010
Fly
response to acid chemicalGO:0001101660.010
neurogenesisGO:00220081690.010
Fly
negative regulation of protein processingGO:00109551420.010
nuclear importGO:00511701060.010
cellular response to growth factor stimulusGO:00713631970.010
primary neural tube formationGO:001402030.010
ribonucleoprotein complex subunit organizationGO:0071826810.010
multicellular organismal homeostasisGO:0048871670.010
forebrain neuron differentiationGO:002187930.010
small molecule biosynthetic processGO:00442831570.010
response to lipidGO:00339932060.010
canonical wnt signaling pathwayGO:00600701160.010
skin developmentGO:0043588760.010
cellular response to transforming growth factor beta stimulusGO:0071560940.010
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.010
actin filament based movementGO:0030048170.010
regulation of response to woundingGO:19030341010.010

PPM1A disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.068
organ system cancerDOID:00506861640.068
cancerDOID:1621670.068
gastrointestinal system cancerDOID:3119520.012
thoracic cancerDOID:5093210.011
breast cancerDOID:1612210.011
nervous system diseaseDOID:8634310.011
central nervous system diseaseDOID:3311860.011