Homo sapiens

539 known processes

PARK7

Parkinson disease (autosomal recessive, early onset) 7

(Aliases: DJ-1,DJ1,FLJ27376,FLJ34360,FLJ92274)

PARK7 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to superoxideGO:007145160.842
cellular response to oxygen radicalGO:007145060.712
positive regulation of cytokine productionGO:00018191670.466
removal of superoxide radicalsGO:001943060.423
posttranscriptional regulation of gene expressionGO:00106082130.415
cellular response to oxygen containing compoundGO:19017012760.373
regulation of defense responseGO:00313471540.347
Mouse
regulation of cysteine type endopeptidase activityGO:20001161270.318
hydrogen peroxide metabolic processGO:0042743200.308
cellular response to reactive oxygen speciesGO:0034614500.239
cytokine productionGO:00018162470.237
positive regulation of apoptotic processGO:00430652460.237
Mouse
multicellular organismal agingGO:001025930.229
determination of adult lifespanGO:000834020.214
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.202
cellular response to hydrogen peroxideGO:0070301370.194
nucleoside phosphate catabolic processGO:19012924120.191
protein processingGO:00164852260.186
hydrogen peroxide catabolic processGO:0042744130.186
negative regulation of endopeptidase activityGO:0010951840.185
cellular response to oxidative stressGO:0034599850.182
protein oxidationGO:001815850.182
Mouse
regulation of cellular response to stressGO:00801352440.170
purine ribonucleotide catabolic processGO:00091544040.169
nucleotide catabolic processGO:00091664080.166
peptidyl cysteine oxidationGO:001817110.165
Mouse
purine ribonucleoside metabolic processGO:00461284370.165
positive regulation of oxidative stress induced cell deathGO:190320950.159
Mouse
myeloid cell differentiationGO:00300991170.158
protein maturationGO:00516042330.152
nucleoside catabolic processGO:00091644080.134
post embryonic developmentGO:000979120.134
purine containing compound catabolic processGO:00725234110.134
regulation of membrane potentialGO:0042391950.130
purine nucleotide catabolic processGO:00061954050.126
response to oxygen radicalGO:000030560.123
regulation of cellular amine metabolic processGO:0033238110.122
purine ribonucleoside catabolic processGO:00461303980.119
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.115
heat acclimationGO:001028630.112
response to abiotic stimulusGO:00096283360.111
regulation of purine nucleotide metabolic processGO:19005422640.108
purine nucleoside triphosphate metabolic processGO:00091444120.108
regenerationGO:003109940.107
response to oxygen containing compoundGO:19017003690.107
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.105
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.104
negative regulation of immune system processGO:00026831360.104
negative regulation of peptidase activityGO:0010466910.100
cell developmentGO:00484683280.097
positive regulation of developmental processGO:00510943140.096
positive regulation of intrinsic apoptotic signaling pathwayGO:2001244280.093
Mouse
organic hydroxy compound biosynthetic processGO:1901617710.093
ribonucleotide catabolic processGO:00092614050.090
apoptotic signaling pathwayGO:00971902680.089
ribonucleoside triphosphate catabolic processGO:00092033910.087
response to inorganic substanceGO:00100351270.087
positive regulation of programmed cell deathGO:00430682490.087
Mouse
positive regulation of response to oxidative stressGO:190288470.086
negative regulation of apoptotic processGO:00430663160.084
regulation of endopeptidase activityGO:00525481700.082
anatomical structure homeostasisGO:00602491000.082
lipid metabolic processGO:00066293810.080
reactive oxygen species biosynthetic processGO:190340940.079
Mouse
nucleoside triphosphate catabolic processGO:00091433940.076
regulation of apoptotic signaling pathwayGO:20012331750.076
regulation of sequence specific dna binding transcription factor activityGO:00510902110.074
rna interferenceGO:001624640.074
response to lipidGO:00339932060.070
negative regulation of programmed cell deathGO:00430693210.070
regulation of nucleotide metabolic processGO:00061402690.070
ribonucleoside catabolic processGO:00424544060.068
retina homeostasisGO:0001895420.068
positive regulation of apoptotic signaling pathwayGO:2001235700.068
Mouse
regulation of gtpase activityGO:00430871800.067
response to hydrogen peroxideGO:0042542400.067
fatty acid metabolic processGO:00066311150.066
positive regulation of cell proliferationGO:00082843010.065
cellular response to dna damage stimulusGO:00069743790.064
monocarboxylic acid metabolic processGO:00327871850.064
superoxide metabolic processGO:0006801200.063
positive regulation of nf kappab transcription factor activityGO:0051092810.063
glycosyl compound catabolic processGO:19016584130.063
cellular amine metabolic processGO:0044106410.062
purine ribonucleoside triphosphate catabolic processGO:00092073910.059
reactive oxygen species metabolic processGO:0072593750.059
response to oxidative stressGO:00069791210.059
ribonucleoside triphosphate metabolic processGO:00091994120.059
female gamete generationGO:000729220.056
regulation of kinase activityGO:00435493140.054
negative regulation of cell deathGO:00605483450.053
protein localization to organelleGO:00333652800.053
negative regulation of cellular protein metabolic processGO:00322693530.053
peptidyl cysteine modificationGO:001819890.053
Mouse
cellular lipid metabolic processGO:00442553030.052
proton transportGO:0015992220.051
Mouse
regulation of cellular amino acid metabolic processGO:000652160.051
organophosphate catabolic processGO:00464344300.051
guanosine containing compound metabolic processGO:19010682440.050
tissue regenerationGO:004224630.049
regulation of cell cycleGO:00517263930.049
purine nucleoside triphosphate catabolic processGO:00091463920.046
negative regulation of protein metabolic processGO:00512483910.046
response to other organismGO:00517072610.042
immune system developmentGO:00025201950.042
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043154460.042
negative regulation of catalytic activityGO:00430863350.042
gtp metabolic processGO:00460392390.042
response to bacteriumGO:00096171440.041
regulation of gtp catabolic processGO:00331241800.041
regulation of multi organism processGO:00439001570.041
hemopoiesisGO:00300971800.041
positive regulation of cell deathGO:00109422630.041
Mouse
ras protein signal transductionGO:0007265730.040
chromatin organizationGO:00063253510.039
inflammatory responseGO:0006954790.039
Mouse
nucleoside monophosphate catabolic processGO:00091251590.039
positive regulation of protein phosphorylationGO:00019343130.038
cellular homeostasisGO:00197251960.037
lipid biosynthetic processGO:00086101770.037
positive regulation of superoxide anion generationGO:003293040.037
response to metal ionGO:0010038840.036
regulation of lipid metabolic processGO:0019216960.036
small gtpase mediated signal transductionGO:0007264780.036
cell death in response to oxidative stressGO:0036473290.035
positive regulation of nucleotide metabolic processGO:00459812300.034
regulation of nucleotide catabolic processGO:00308112050.033
gtp catabolic processGO:00061842370.033
response to reactive oxygen speciesGO:0000302610.032
endocytosisGO:00068971590.031
regulation of peptidase activityGO:00525471800.031
regulation of transferase activityGO:00513383550.031
nitrogen compound transportGO:00717051910.031
Mouse
steroid metabolic processGO:0008202940.030
mrna metabolic processGO:00160711750.030
cell type specific apoptotic processGO:00972851250.030
immune responseGO:00069553070.030
regulation of small gtpase mediated signal transductionGO:00510561560.029
regulation of response to woundingGO:19030341010.029
Mouse
alcohol metabolic processGO:00060661140.029
positive regulation of reactive oxygen species metabolic processGO:2000379240.029
protein acetylationGO:00064731160.028
response to external biotic stimulusGO:00432072610.028
carbohydrate derivative biosynthetic processGO:19011372070.028
nucleoside monophosphate metabolic processGO:00091231910.028
response to woundingGO:00096111680.028
Mouse
muscle structure developmentGO:0061061980.028
response to superoxideGO:000030360.028
regulation of ras protein signal transductionGO:00465781550.027
regulation of protein processingGO:00706131500.027
hematopoietic or lymphoid organ developmentGO:00485341860.026
internal protein amino acid acetylationGO:00064751010.026
innate immune responseGO:00450871780.026
regulation of protein maturationGO:19033171500.026
oogenesisGO:004847720.026
positive regulation of cellular response to oxidative stressGO:190040970.026
thymus developmentGO:004853830.025
bleb assemblyGO:003206060.025
regulation of nucleoside metabolic processGO:00091182090.024
defense responseGO:00069523150.024
Mouse
receptor mediated endocytosisGO:0006898840.024
heart processGO:0003015620.023
embryo developmentGO:00097901230.023
cell agingGO:0007569520.023
regulation of protein kinase activityGO:00458592890.023
chromatin modificationGO:00165682980.023
gene silencingGO:0016458490.023
protein modification by small protein conjugationGO:00324463420.023
negative regulation of response to external stimulusGO:0032102830.023
regulation of cell cycle processGO:00105642660.023
positive regulation of cellular amino acid metabolic processGO:004576430.023
nucleotide biosynthetic processGO:00091651090.022
negative regulation of phosphorus metabolic processGO:00105632670.022
response to xenobiotic stimulusGO:0009410300.022
covalent chromatin modificationGO:00165692540.022
negative regulation of protein maturationGO:19033181420.022
guanosine containing compound catabolic processGO:19010692390.022
intrinsic apoptotic signaling pathway in response to oxidative stressGO:0008631210.021
ribonucleotide biosynthetic processGO:0009260810.021
amine metabolic processGO:0009308440.021
negative regulation of multicellular organismal processGO:00512413170.021
regulation of purine nucleotide catabolic processGO:00331212050.021
amide transportGO:0042886760.021
response to biotic stimulusGO:00096072760.020
positive regulation of cellular component organizationGO:00511303760.020
growthGO:00400072020.020
organic hydroxy compound metabolic processGO:19016151470.019
cell divisionGO:00513011680.019
regulation of mitochondrial membrane potentialGO:0051881230.019
cofactor metabolic processGO:0051186870.019
atp metabolic processGO:00460341760.018
reproductive processGO:00224141060.018
regulation of cell growthGO:00015581350.018
regulation of response to external stimulusGO:00321012220.018
Mouse
immune effector processGO:00022521590.018
negative regulation of protein processingGO:00109551420.018
regulation of leukocyte differentiationGO:1902105610.018
nervous system developmentGO:00073992930.018
nucleoside triphosphate metabolic processGO:00091414220.018
reproductionGO:0000003630.017
system processGO:00030083490.017
regulation of proteolysisGO:00301622930.017
gene silencing by rnaGO:0031047260.016
single organism reproductive processGO:0044702980.016
cytoplasmic transportGO:00164823790.016
glucose homeostasisGO:0042593310.016
regulation of innate immune responseGO:0045088970.016
cellular amino acid metabolic processGO:00065201160.016
negative regulation of cell growthGO:0030308830.016
regulation of neurogenesisGO:0050767820.015
negative regulation of apoptotic signaling pathwayGO:2001234970.015
methylationGO:00322591060.015
regulation of cell developmentGO:00602841610.015
positive regulation of cellular amine metabolic processGO:003324070.015
wound healingGO:00420601150.015
tissue homeostasisGO:0001894630.015
agingGO:0007568660.014
steroid biosynthetic processGO:0006694460.014
cell fate commitmentGO:0045165270.014
regulation of secretion by cellGO:19035301770.014
nucleic acid phosphodiester bond hydrolysisGO:00903051020.014
heart contractionGO:0060047620.014
multicellular organismal homeostasisGO:0048871670.014
regulation of inflammatory responseGO:0050727460.014
Mouse
protein oligomerizationGO:00512591730.014
regulation of epithelial cell proliferationGO:00506781130.014
neuron differentiationGO:00301821380.014
regulation of gene expression epigeneticGO:0040029730.014
ribonucleoside monophosphate catabolic processGO:00091581580.014
response to alcoholGO:0097305640.014
regulation of i kappab kinase nf kappab signalingGO:00431221620.014
embryo development ending in birth or egg hatchingGO:0009792340.014
developmental process involved in reproductionGO:0003006660.013
cell activationGO:00017752130.013
leukocyte activationGO:00453211640.013
purine nucleoside monophosphate metabolic processGO:00091261860.013
coenzyme metabolic processGO:0006732650.013
histone methylationGO:0016571600.013
dna repairGO:00062811980.013
positive regulation of peptidase activityGO:0010952880.013
purine ribonucleoside triphosphate metabolic processGO:00092054110.013
protein methylationGO:0006479740.013
regulation of neuron deathGO:1901214560.013
segmentationGO:003528240.013
neuron cellular homeostasisGO:007005030.013
positive regulation of cysteine type endopeptidase activityGO:2001056790.013
rho protein signal transductionGO:0007266260.013
neuron deathGO:0070997650.013
mrna processingGO:00063971330.012
response to hormoneGO:00097251750.012
negative regulation of hydrolase activityGO:00513461820.012
mitotic cell cycleGO:00002783260.012
cell projection morphogenesisGO:00488581290.012
regulation of immune responseGO:00507762010.012
protein homooligomerizationGO:00512601000.012
positive regulation of cell migrationGO:00303351720.012
erythrocyte homeostasisGO:0034101310.012
regulation of growthGO:00400081650.012
regulation of establishment of protein localizationGO:00702012420.012
cellular component morphogenesisGO:00329893140.012
positive regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217740.012
Mouse
epithelial cell proliferationGO:00506731280.012
small molecule biosynthetic processGO:00442831570.012
positive regulation of purine nucleotide metabolic processGO:19005442270.012
neuron developmentGO:00486661130.012
cellular macromolecule catabolic processGO:00442653800.012
regulation of mitotic cell cycleGO:00073461890.012
regulation of ras gtpase activityGO:00323181280.012
inorganic ion transmembrane transportGO:00986602310.012
posttranscriptional gene silencingGO:0016441250.012
regulation of superoxide metabolic processGO:009032260.011
leukocyte proliferationGO:0070661740.011
cellular response to lipidGO:00713961270.011
lymphocyte activationGO:00466491330.011
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.011
regulation of cholesterol metabolic processGO:009018140.011
organelle fissionGO:00482851490.011
single organism cellular localizationGO:19025803320.011
posttranscriptional gene silencing by rnaGO:0035194250.011
cellular macromolecular complex assemblyGO:00346223240.011
rna splicing via transesterification reactionsGO:0000375900.011
response to drugGO:0042493810.011
protein alkylationGO:0008213740.011
response to monosaccharideGO:0034284200.011
sterol metabolic processGO:0016125280.010
sulfur compound metabolic processGO:00067901010.010
regulation of rac gtpase activityGO:003231440.010
response to acid chemicalGO:0001101660.010
regulation of protein localizationGO:00328802960.010
response to temperature stimulusGO:0009266220.010
purine ribonucleoside monophosphate catabolic processGO:00091691580.010

PARK7 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.054
cancerDOID:1621670.054
nervous system diseaseDOID:8634310.031
central nervous system diseaseDOID:3311860.031
organ system cancerDOID:00506861640.019
neurodegenerative diseaseDOID:12891020.004
synucleinopathyDOID:0050890220.000
parkinson s diseaseDOID:14330180.000