Homo sapiens

6 known processes

PHGDH

phosphoglycerate dehydrogenase

(Aliases: PGD,3-PGDH,PGAD,PGDH,MGC3017,SERA,PDG,3PGDH)

PHGDH biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dicarboxylic acid metabolic processGO:0043648290.472
alpha amino acid metabolic processGO:1901605720.362
Mouse
response to oxygen containing compoundGO:19017003690.195
alanine metabolic processGO:000652240.194
post embryonic developmentGO:000979120.129
alpha amino acid catabolic processGO:1901606260.127
coenzyme metabolic processGO:0006732650.124
organonitrogen compound biosynthetic processGO:19015662000.108
small molecule catabolic processGO:0044282920.097
cofactor metabolic processGO:0051186870.094
cellular amino acid metabolic processGO:00065201160.089
Mouse
serine family amino acid metabolic processGO:0009069120.083
Mouse
organic acid biosynthetic processGO:0016053970.076
water soluble vitamin metabolic processGO:000676760.072
negative regulation of programmed cell deathGO:00430693210.068
amine metabolic processGO:0009308440.068
cellular amino acid catabolic processGO:0009063310.067
carboxylic acid catabolic processGO:0046395710.063
negative regulation of cell deathGO:00605483450.062
negative regulation of apoptotic processGO:00430663160.061
cellular response to oxygen containing compoundGO:19017012760.061
regulation of cell cycleGO:00517263930.060
chemical homeostasisGO:00488783060.060
one carbon metabolic processGO:000673010.059
nitrogen compound transportGO:00717051910.059
oxidation reduction processGO:00551143960.059
Rat
small molecule biosynthetic processGO:00442831570.058
regulation of cellular amino acid metabolic processGO:000652160.057
female gamete generationGO:000729220.056
regulation of cellular ketone metabolic processGO:0010565500.056
protein oligomerizationGO:00512591730.056
organic acid catabolic processGO:0016054710.054
response to nitrogen compoundGO:19016981840.053
oogenesisGO:004847720.052
response to organonitrogen compoundGO:00102431560.051
cellular amine metabolic processGO:0044106410.049
cellular ketone metabolic processGO:0042180800.049
negative regulation of protein metabolic processGO:00512483910.046
negative regulation of catalytic activityGO:00430863350.044
regulation of cellular amine metabolic processGO:0033238110.044
cellular response to endogenous stimulusGO:00714953360.044
positive regulation of cellular amino acid metabolic processGO:004576430.043
cellular modified amino acid metabolic processGO:0006575640.040
carbohydrate metabolic processGO:00059752070.039
positive regulation of cellular amine metabolic processGO:003324070.039
response to lipidGO:00339932060.039
negative regulation of cellular component organizationGO:00511292350.038
l serine metabolic processGO:000656350.038
Mouse
purine nucleobase biosynthetic processGO:000911330.038
lipid biosynthetic processGO:00086101770.037
proline transportGO:001582440.036
regulation of protein kinase activityGO:00458592890.036
mitotic cell cycle processGO:19030472860.036
cellular macromolecule catabolic processGO:00442653800.036
mapk cascadeGO:00001652880.034
regulation of hormone secretionGO:0046883570.033
regulation of hormone levelsGO:00108171250.032
signal transduction by phosphorylationGO:00230142970.032
negative regulation of phosphate metabolic processGO:00459362670.032
mitotic cell cycleGO:00002783260.032
transmembrane transportGO:00550853990.032
ion transmembrane transportGO:00342203380.032
cell developmentGO:00484683280.032
Mouse
pyruvate family amino acid metabolic processGO:000907840.032
sulfur compound biosynthetic processGO:0044272380.032
single organism carbohydrate metabolic processGO:00447231930.031
regulation of mitotic cell cycleGO:00073461890.031
cellular modified amino acid catabolic processGO:004221940.031
cellular response to dna damage stimulusGO:00069743790.031
enzyme linked receptor protein signaling pathwayGO:00071673030.030
system processGO:00030083490.030
positive regulation of transportGO:00510503360.030
cellular response to hormone stimulusGO:00328701250.030
response to external biotic stimulusGO:00432072610.030
apoptotic signaling pathwayGO:00971902680.029
regulation of kinase activityGO:00435493140.029
nucleobase biosynthetic processGO:004611240.029
cell type specific apoptotic processGO:00972851250.029
carboxylic acid biosynthetic processGO:0046394970.029
cytokine productionGO:00018162470.029
regulation of cell cycle processGO:00105642660.029
posttranscriptional regulation of gene expressionGO:00106082130.028
negative regulation of multicellular organismal processGO:00512413170.028
positive regulation of secretion by cellGO:19035321080.028
positive regulation of phosphorylationGO:00423273940.028
negative regulation of cellular protein metabolic processGO:00322693530.028
response to abiotic stimulusGO:00096283360.028
monocarboxylic acid metabolic processGO:00327871850.028
Mouse
protein modification by small protein conjugationGO:00324463420.028
purine ribonucleoside metabolic processGO:00461284370.028
cerebellum developmentGO:002154920.027
positive regulation of cellular component organizationGO:00511303760.027
rna processingGO:00063962550.027
regulation of cell differentiationGO:00455953930.027
response to biotic stimulusGO:00096072760.027
negative regulation of developmental processGO:00510932470.027
regulation of cellular component biogenesisGO:00440872810.027
response to organic cyclic compoundGO:00140702040.026
actin filament based processGO:00300292240.026
regulation of secretionGO:00510461940.026
regenerationGO:003109940.026
regulation of transferase activityGO:00513383550.026
positive regulation of cell cycleGO:00457871400.025
cation transportGO:00068123310.025
negative regulation of protein modification processGO:00314002000.025
inorganic ion transmembrane transportGO:00986602310.025
regulation of cellular component movementGO:00512703340.025
segmentationGO:003528240.024
defense responseGO:00069523150.024
chloride transmembrane transportGO:1902476380.024
cellular response to nitrogen compoundGO:19016991440.024
lipid metabolic processGO:00066293810.024
protein catabolic processGO:00301633250.024
cellular lipid metabolic processGO:00442553030.024
cell cycle phase transitionGO:00447701730.023
regulation of mapk cascadeGO:00434082620.023
protein tetramerizationGO:0051262470.023
purine nucleoside triphosphate metabolic processGO:00091444120.023
negative regulation of phosphorus metabolic processGO:00105632670.023
ras protein signal transductionGO:0007265730.023
purine ribonucleoside triphosphate metabolic processGO:00092054110.023
regulation of sequence specific dna binding transcription factor activityGO:00510902110.022
purine nucleoside catabolic processGO:00061523980.022
organelle assemblyGO:00709251760.022
small gtpase mediated signal transductionGO:0007264780.022
positive regulation of cell proliferationGO:00082843010.021
positive regulation of immune system processGO:00026842830.021
nervous system developmentGO:00073992930.021
Mouse
secretion by cellGO:00329402260.021
cell adhesionGO:00071553250.021
cytoplasmic transportGO:00164823790.021
protein ubiquitinationGO:00165673140.021
mitotic cell cycle phase transitionGO:00447721620.021
response to acid chemicalGO:0001101660.020
regulation of cell motilityGO:20001452990.020
positive regulation of programmed cell deathGO:00430682490.020
modification dependent protein catabolic processGO:00199412090.020
regulation of proteolysisGO:00301622930.020
neuromuscular junction developmentGO:000752830.020
cellular response to lipidGO:00713961270.020
proteolysis involved in cellular protein catabolic processGO:00516032440.020
vitamin metabolic processGO:0006766260.020
regulation of locomotionGO:00400123290.020
purine containing compound catabolic processGO:00725234110.020
pigment biosynthetic processGO:0046148100.020
negative regulation of hydrolase activityGO:00513461820.020
organic hydroxy compound metabolic processGO:19016151470.020
protein maturationGO:00516042330.020
protein acetylationGO:00064731160.020
multicellular organismal agingGO:001025930.020
ribonucleoside catabolic processGO:00424544060.019
reactive oxygen species metabolic processGO:0072593750.019
determination of adult lifespanGO:000834020.019
immune responseGO:00069553070.019
positive regulation of developmental processGO:00510943140.019
modified amino acid transportGO:0072337110.019
ribonucleoside triphosphate catabolic processGO:00092033910.019
organic acid transportGO:0015849650.019
innate immune responseGO:00450871780.019
regulation of protein complex assemblyGO:00432541470.019
single organism cellular localizationGO:19025803320.019
organophosphate catabolic processGO:00464344300.019
response to peptide hormoneGO:0043434610.019
response to other organismGO:00517072610.019
biological adhesionGO:00226103310.019
purine ribonucleotide catabolic processGO:00091544040.019
membrane organizationGO:00610242920.019
secretionGO:00469032540.019
rho protein signal transductionGO:0007266260.019
single organism membrane organizationGO:00448022680.018
protein acylationGO:00435431380.018
regulation of protein serine threonine kinase activityGO:00719001790.018
positive regulation of transferase activityGO:00513472270.018
hindbrain developmentGO:003090230.018
positive regulation of catabolic processGO:00098963100.018
nucleoside phosphate catabolic processGO:19012924120.018
regulation of peptide secretionGO:0002791420.018
cellular protein catabolic processGO:00442572610.018
cell morphogenesisGO:00009022960.018
ncrna processingGO:0034470830.018
growthGO:00400072020.018
positive regulation of secretionGO:00510471160.018
cellular component morphogenesisGO:00329893140.018
locomotory behaviorGO:000762610.018
organic anion transportGO:00157111030.018
memoryGO:000761330.018
regulation of cellular response to stressGO:00801352440.018
atp metabolic processGO:00460341760.018
purine nucleoside triphosphate catabolic processGO:00091463920.018
compound eye developmentGO:004874910.018
protein processingGO:00164852260.018
cellular homeostasisGO:00197251960.017
cardiovascular system developmentGO:00723582620.017
positive regulation of cell deathGO:00109422630.017
response to hormoneGO:00097251750.017
regulation of cell migrationGO:00303342890.017
cellular macromolecular complex assemblyGO:00346223240.017
ribonucleotide catabolic processGO:00092614050.017
purine ribonucleoside catabolic processGO:00461303980.017
cation transmembrane transportGO:00986552380.017
patterning of blood vesselsGO:000156920.017
anatomical structure formation involved in morphogenesisGO:00486462840.017
positive regulation of hydrolase activityGO:00513453310.017
positive regulation of apoptotic processGO:00430652460.017
nucleoside triphosphate metabolic processGO:00091414220.017
monocarboxylic acid biosynthetic processGO:0072330670.017
nucleoside triphosphate catabolic processGO:00091433940.017
regulation of establishment of protein localizationGO:00702012420.017
cell projection organizationGO:00300302520.017
Mouse
dephosphorylationGO:00163112090.017
ubiquitin dependent protein catabolic processGO:00065112060.017
negative regulation of intracellular signal transductionGO:19025321830.017
negative regulation of cell cycleGO:00457861930.017
cellular amino acid biosynthetic processGO:0008652300.017
regulation of anatomical structure morphogenesisGO:00226032860.017
anion transmembrane transportGO:0098656760.017
positive regulation of cellular catabolic processGO:00313312840.017
blastoderm segmentationGO:000735020.017
regulation of protein localizationGO:00328802960.017
circulatory system developmentGO:00723592620.017
nucleotide catabolic processGO:00091664080.017
intracellular protein transportGO:00068862700.016
regulation of cytokine productionGO:00018172320.016
chromatin organizationGO:00063253510.016
morphogenesis of embryonic epitheliumGO:001633140.016
neurological system processGO:00508771630.016
morphogenesis of a polarized epitheliumGO:000173830.016
ribonucleoside triphosphate metabolic processGO:00091994120.016
purine ribonucleoside triphosphate catabolic processGO:00092073910.016
regulation of cell growthGO:00015581350.016
amino acid activationGO:0043038120.016
vesicle mediated transportGO:00161923710.016
negative regulation of cell migrationGO:00303361020.016
response to insulinGO:0032868450.016
regulation of cell cycle phase transitionGO:19019871260.016
regulation of growthGO:00400081650.016
hexose metabolic processGO:0019318550.016
negative regulation of cell cycle processGO:00109481210.016
purine nucleoside monophosphate metabolic processGO:00091261860.016
cellular protein complex assemblyGO:00436231880.016
modification dependent macromolecule catabolic processGO:00436322120.016
regulation of cytoskeleton organizationGO:00514931770.016
catagenGO:004263730.015
syncytium formation by plasma membrane fusionGO:000076820.015
oocyte developmentGO:004859910.015
regulation of reactive oxygen species metabolic processGO:2000377410.015
chloride transportGO:0006821410.015
guanosine containing compound metabolic processGO:19010682440.015
amide transportGO:0042886760.015
purine containing compound biosynthetic processGO:0072522880.015
epithelium developmentGO:00604292270.015
Mouse
positive regulation of kinase activityGO:00336742040.015
reactive oxygen species biosynthetic processGO:190340940.015
neuron apoptotic processGO:0051402390.015
head developmentGO:00603221080.015
regulation of response to external stimulusGO:00321012220.015
purine nucleotide catabolic processGO:00061954050.015
regulation of secretion by cellGO:19035301770.015
regulation of peptide transportGO:0090087620.015
proteasomal protein catabolic processGO:00104981760.015
regulation of immune responseGO:00507762010.015
carbohydrate derivative biosynthetic processGO:19011372070.015
regulation of nucleotide metabolic processGO:00061402690.015
response to oxidative stressGO:00069791210.015
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.015
salivary gland morphogenesisGO:000743540.015
positive regulation of cell differentiationGO:00455972110.015
oocyte differentiationGO:000999420.015
guanosine containing compound catabolic processGO:19010692390.015
actin cytoskeleton organizationGO:00300362070.015
cell growthGO:00160491600.015
positive regulation of protein phosphorylationGO:00019343130.015
negative regulation of cell proliferationGO:00082852280.015
negative regulation of cellular amino acid metabolic processGO:004576320.015
negative regulation of cell differentiationGO:00455961710.015
internal protein amino acid acetylationGO:00064751010.015
response to bacteriumGO:00096171440.015
signal releaseGO:0023061700.014
reactive nitrogen species metabolic processGO:200105730.014
cardiac muscle cell contractionGO:008600340.014
cellular chemical homeostasisGO:00550821800.014
protein homooligomerizationGO:00512601000.014
microtubule based processGO:00070172100.014
regulation of protein transportGO:00512232130.014
regulation of multi organism processGO:00439001570.014
nucleocytoplasmic transportGO:00069131760.014
serine family amino acid catabolic processGO:000907150.014
regulation of endopeptidase activityGO:00525481700.014
regulation of bindingGO:00510981110.014
positive regulation of purine nucleotide metabolic processGO:19005442270.014
rhythmic behaviorGO:000762220.014
regulation of intracellular transportGO:00323861950.014
peptide transportGO:0015833740.014
somatic stem cell maintenanceGO:003501940.014
cellular amide metabolic processGO:0043603690.014
regulation of neural precursor cell proliferationGO:200017740.014
pharynx developmentGO:006046510.014
nucleoside catabolic processGO:00091644080.014
sulfur compound metabolic processGO:00067901010.014
Mouse
response to growth factorGO:00708482050.014
hormone transportGO:0009914680.014
negative regulation of phosphorylationGO:00423261740.014
glycosyl compound catabolic processGO:19016584130.014
blood vessel morphogenesisGO:00485141620.014
spermatid differentiationGO:004851540.014
cell activationGO:00017752130.014
pyruvate metabolic processGO:0006090260.014
negative regulation of cell motilityGO:20001461040.014
response to steroid hormoneGO:0048545800.014
organophosphate biosynthetic processGO:00904071630.014
negative regulation of transferase activityGO:00513481240.014
negative regulation of protein maturationGO:19033181420.014
positive regulation of protein kinase activityGO:00458601900.014
protein localization to organelleGO:00333652800.014
hormone secretionGO:0046879650.013
negative regulation of cellular amine metabolic processGO:003323930.013
i kappab kinase nf kappab signalingGO:00072491660.013
canonical wnt signaling pathwayGO:00600701160.013
inner ear morphogenesisGO:004247240.013
regulation of reactive oxygen species biosynthetic processGO:190342630.013
alpha amino acid biosynthetic processGO:1901607230.013
peripheral nervous system developmentGO:000742220.013
regulation of protein maturationGO:19033171500.013
wnt signaling pathwayGO:00160551560.013
negative regulation of cellular component movementGO:00512711060.013
neuron developmentGO:00486661130.013
Mouse
epidermis developmentGO:0008544590.013
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.013
motor neuron axon guidanceGO:000804520.013
positive regulation of cellular component biogenesisGO:00440891580.013
brain developmentGO:0007420970.013
ion homeostasisGO:00508012300.013
regulation of purine nucleotide metabolic processGO:19005422640.013
regulation of protein modification by small protein conjugation or removalGO:19033201070.013
oxidoreduction coenzyme metabolic processGO:0006733190.013
cellular response to growth factor stimulusGO:00713631970.013
neurotransmitter secretionGO:000726940.013
negative regulation of protein processingGO:00109551420.013
response to radiationGO:00093141510.013
positive regulation of cellular protein catabolic processGO:1903364370.013
single organism cell adhesionGO:00986021790.013
cell divisionGO:00513011680.013
positive regulation of organelle organizationGO:00106381950.013
cell fate determinationGO:000170930.013
cellular response to cytokine stimulusGO:00713451810.013
peptide secretionGO:0002790510.013
negative regulation of protein complex assemblyGO:0031333430.013
ribonucleoside monophosphate metabolic processGO:00091611870.013
negative regulation of organelle organizationGO:00106391260.012
adult locomotory behaviorGO:000834410.012
inorganic cation transmembrane transportGO:00986621940.012
striated muscle contractionGO:0006941520.012
positive regulation of immune responseGO:00507781590.012
tripartite regional subdivisionGO:000735120.012
epithelial cell differentiationGO:00308551410.012
cell projection assemblyGO:00300311260.012
regulation of cell adhesionGO:00301551660.012
negative regulation of cytokine productionGO:0001818820.012
anterior posterior axis specificationGO:000994820.012
endocytosisGO:00068971590.012
metencephalon developmentGO:002203720.012
metal ion transportGO:00300012720.012
positive regulation of mitotic cell cycleGO:0045931600.012
vasculature developmentGO:00019441810.012
tissue regenerationGO:004224630.012
photoreceptor cell differentiationGO:004653020.012
spermatid developmentGO:000728640.012
negative regulation of response to external stimulusGO:0032102830.012
regulation of purine nucleotide catabolic processGO:00331212050.012
embryonic epithelial tube formationGO:000183840.012
cardiac muscle contractionGO:0060048340.012
circadian behaviorGO:004851220.012
regulation of neuron deathGO:1901214560.012
response to axon injuryGO:004867810.012
regulation of wnt signaling pathwayGO:00301111230.012
generation of neuronsGO:00486991520.012
Mouse
carboxylic acid transportGO:0046942630.012
negative regulation of protein kinase activityGO:0006469980.012
regulation of protein processingGO:00706131500.012
fatty acid metabolic processGO:00066311150.012
regulation of apoptotic signaling pathwayGO:20012331750.012
hematopoietic or lymphoid organ developmentGO:00485341860.012
positive regulation of reactive oxygen species metabolic processGO:2000379240.012
forebrain neuron differentiationGO:002187930.012
positive regulation of protein transportGO:00512221350.012
cellular response to abiotic stimulusGO:00712141170.012
regulation of translationGO:0006417890.012
negative regulation of mitotic cell cycleGO:00459301020.012
neuroblast proliferationGO:000740540.012
cellular response to organonitrogen compoundGO:00714171240.012
nucleoside monophosphate metabolic processGO:00091231910.012
regulation of mitosisGO:0007088630.012
hemopoiesisGO:00300971800.012
regulation of cell developmentGO:00602841610.012
negative regulation of locomotionGO:00400131180.012
peptidyl tyrosine phosphorylationGO:00181081700.012
regulation of i kappab kinase nf kappab signalingGO:00431221620.012
regulation of peptidase activityGO:00525471800.012
ribonucleotide biosynthetic processGO:0009260810.012
endomembrane system organizationGO:00102561960.012
peptidyl tyrosine modificationGO:00182121700.012
reproductive processGO:00224141060.012
regulation of defense responseGO:00313471540.012
regulation of insulin secretionGO:0050796330.011
nuclear transportGO:00511691790.011
response to metal ionGO:0010038840.011
positive regulation of protein modification by small protein conjugation or removalGO:1903322610.011
release of cytoplasmic sequestered nf kappabGO:000858840.011
meiosis iGO:000712740.011
cysteine metabolic processGO:000653440.011
translationGO:00064121320.011
limbic system developmentGO:002176130.011
positive regulation of proteolysisGO:00458621420.011
peptide hormone secretionGO:0030072500.011
anion transportGO:00068201610.011
epidermis morphogenesisGO:004873030.011
response to fungusGO:000962040.011
epithelial cell migrationGO:00106311190.011
organelle fissionGO:00482851490.011
regulation of cytoplasmic transportGO:19036491490.011
positive regulation of mapk cascadeGO:00434101900.011
regulation of gtpase activityGO:00430871800.011
regulation of synaptic plasticityGO:004816730.011
cap independent translational initiationGO:000219040.011
extrinsic apoptotic signaling pathwayGO:00971911190.011
cerebellar cortex developmentGO:002169510.011
organ formationGO:004864530.011
rna interferenceGO:001624640.011
response to lipopolysaccharideGO:0032496700.011
positive regulation of reactive oxygen species biosynthetic processGO:190342820.011
regulation of cell divisionGO:00513021160.011
mitotic nuclear divisionGO:00070671190.011
regulation of nucleotide catabolic processGO:00308112050.011
positive regulation of cell developmentGO:0010720920.011
negative regulation of kinase activityGO:00336731060.011
muscle contractionGO:0006936730.011
protein targetingGO:00066051870.011
forebrain generation of neuronsGO:002187230.011
developmental programmed cell deathGO:001062330.011
macromolecule methylationGO:0043414970.011
chemotaxisGO:00069351570.011
axon cargo transportGO:000808820.011
negative regulation of cell fate commitmentGO:001045430.011
glial cell migrationGO:000834740.011
alanine transportGO:003232830.011
response to cytokineGO:00340972320.011
maintenance of locationGO:00512351120.011
positive regulation of nucleoside metabolic processGO:00459791860.011
regulation of peptide hormone secretionGO:0090276410.011
positive regulation of neural precursor cell proliferationGO:200017920.011
l amino acid importGO:004309240.011
blood vessel developmentGO:00015681720.011
stress activated mapk cascadeGO:0051403930.011
actin mediated cell contractionGO:0070252120.011
single organismal cell cell adhesionGO:00163371480.011
cell projection morphogenesisGO:00488581290.011
phospholipid metabolic processGO:0006644990.011
establishment of planar polarityGO:000173630.010
regulation of vesicle mediated transportGO:00606271300.010
sulfur compound catabolic processGO:004427380.010
regulation of mitotic cell cycle phase transitionGO:19019901180.010
angiogenesisGO:00015251470.010
gtp catabolic processGO:00061842370.010
retinal ganglion cell axon guidanceGO:003129020.010
positive regulation of synaptic transmissionGO:005080640.010
nadh metabolic processGO:000673410.010
muscle system processGO:0003012810.010
establishment of tissue polarityGO:000716430.010
cell morphogenesis involved in differentiationGO:00009041440.010
neural tube formationGO:000184130.010
response to inorganic substanceGO:00100351270.010
cell part morphogenesisGO:00329901370.010
ameboidal type cell migrationGO:00016671350.010

PHGDH disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.240
inherited metabolic disorderDOID:6552420.240
amino acid metabolic disorderDOID:9252500.240
neuropathyDOID:870520.029
nervous system diseaseDOID:8634310.029
central nervous system diseaseDOID:3311860.026
eye and adnexa diseaseDOID:14921500.023
sensory system diseaseDOID:00501552030.023
eye diseaseDOID:56141490.023
musculoskeletal system diseaseDOID:172230.020
disease of cellular proliferationDOID:145661740.018
cancerDOID:1621670.018
organ system cancerDOID:00506861640.018
connective tissue diseaseDOID:651090.017
bone diseaseDOID:0080001880.014
retinal diseaseDOID:56791180.014
immune system diseaseDOID:29141550.011
neuromuscular diseaseDOID:440380.011
charcot marie tooth diseaseDOID:10595330.011
carbohydrate metabolic disorderDOID:2978550.011