Homo sapiens

5 known processes

KCNE3

potassium voltage-gated channel, Isk-related family, member 3

(Aliases: MGC102685,HYPP,MGC129924,DKFZp781H21101,HOKPP,MiRP2)

KCNE3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
locomotory behaviorGO:000762610.276
anterior posterior axis specification embryoGO:000859520.159
post embryonic developmentGO:000979120.158
oogenesisGO:004847720.140
photoreceptor cell differentiationGO:004653020.114
multicellular organismal agingGO:001025930.108
segmentationGO:003528240.107
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.104
purine ribonucleoside triphosphate catabolic processGO:00092073910.102
regulation of locomotionGO:00400123290.101
purine nucleotide catabolic processGO:00061954050.095
regulation of cell developmentGO:00602841610.088
single organism cellular localizationGO:19025803320.084
single organism membrane organizationGO:00448022680.083
intracellular protein transportGO:00068862700.081
gtp metabolic processGO:00460392390.081
purine ribonucleoside triphosphate metabolic processGO:00092054110.078
regulation of i kappab kinase nf kappab signalingGO:00431221620.078
membrane organizationGO:00610242920.073
tripartite regional subdivisionGO:000735120.071
purine ribonucleoside catabolic processGO:00461303980.070
nucleoside catabolic processGO:00091644080.067
cytoplasmic transportGO:00164823790.066
i kappab kinase nf kappab signalingGO:00072491660.066
nucleoside triphosphate catabolic processGO:00091433940.065
purine ribonucleoside metabolic processGO:00461284370.064
positive regulation of transportGO:00510503360.062
nucleotide catabolic processGO:00091664080.061
regulation of protein localizationGO:00328802960.061
female gamete generationGO:000729220.059
regulation of establishment of protein localizationGO:00702012420.059
oxidation reduction processGO:00551143960.058
protein localization to organelleGO:00333652800.058
organophosphate catabolic processGO:00464344300.057
establishment or maintenance of microtubule cytoskeleton polarityGO:003095120.057
regulation of cellular ketone metabolic processGO:0010565500.056
ribonucleotide catabolic processGO:00092614050.056
axon cargo transportGO:000808820.056
cellular macromolecular complex assemblyGO:00346223240.055
purine nucleoside catabolic processGO:00061523980.054
oocyte developmentGO:004859910.054
negative regulation of rho gtpase activityGO:003425940.054
guanosine containing compound catabolic processGO:19010692390.052
nucleoside phosphate catabolic processGO:19012924120.052
determination of adult lifespanGO:000834020.052
system processGO:00030083490.052
metal ion transportGO:00300012720.051
positive regulation of nucleoside metabolic processGO:00459791860.051
regulation of cell maturationGO:190342930.050
cellular amino acid metabolic processGO:00065201160.049
ribonucleoside triphosphate metabolic processGO:00091994120.049
establishment or maintenance of cytoskeleton polarityGO:003095230.049
ribonucleoside catabolic processGO:00424544060.049
ribonucleoprotein complex subunit organizationGO:0071826810.048
ribonucleoside triphosphate catabolic processGO:00092033910.048
establishment of nucleus localizationGO:004002310.048
purine nucleoside triphosphate catabolic processGO:00091463920.047
regulation of cell differentiationGO:00455953930.047
carbohydrate metabolic processGO:00059752070.047
amine metabolic processGO:0009308440.046
negative regulation of cellular amine metabolic processGO:003323930.046
neurotransmitter secretionGO:000726940.046
positive regulation of catabolic processGO:00098963100.045
purine containing compound catabolic processGO:00725234110.044
regulation of mapk cascadeGO:00434082620.044
nervous system developmentGO:00073992930.044
immune responseGO:00069553070.044
small gtpase mediated signal transductionGO:0007264780.043
endomembrane system organizationGO:00102561960.043
regulation of cell motilityGO:20001452990.043
regulation of cellular component biogenesisGO:00440872810.043
positive regulation of transferase activityGO:00513472270.042
maintenance of cell polarityGO:003001120.042
ras protein signal transductionGO:0007265730.042
gtp catabolic processGO:00061842370.042
positive regulation of purine nucleotide metabolic processGO:19005442270.042
positive regulation of cellular component organizationGO:00511303760.041
plasma membrane organizationGO:00070091150.041
regulation of cellular amino acid metabolic processGO:000652160.041
cellular amine metabolic processGO:0044106410.040
positive regulation of nucleotide catabolic processGO:00308131850.040
protein localization to membraneGO:00726571600.040
positive regulation of gtpase activityGO:00435471660.039
positive regulation of purine nucleotide catabolic processGO:00331231850.039
positive regulation of phosphorylationGO:00423273940.039
purine ribonucleotide catabolic processGO:00091544040.039
purine nucleoside triphosphate metabolic processGO:00091444120.038
mapk cascadeGO:00001652880.037
cellular ketone metabolic processGO:0042180800.037
cellular component morphogenesisGO:00329893140.037
positive regulation of developmental processGO:00510943140.036
positive regulation of protein kinase activityGO:00458601900.036
regulation of transferase activityGO:00513383550.036
negative regulation of cell proliferationGO:00082852280.035
positive regulation of cellular amino acid metabolic processGO:004576430.035
negative regulation of phosphate metabolic processGO:00459362670.035
regulation of gtp catabolic processGO:00331241800.034
positive regulation of synaptic transmissionGO:005080640.034
glycosyl compound catabolic processGO:19016584130.033
regulation of cellular amine metabolic processGO:0033238110.033
positive regulation of cellular catabolic processGO:00313312840.033
regulation of cellular response to stressGO:00801352440.032
positive regulation of protein phosphorylationGO:00019343130.032
regulation of nucleotide catabolic processGO:00308112050.032
response to oxygen containing compoundGO:19017003690.031
response to other organismGO:00517072610.031
negative regulation of catalytic activityGO:00430863350.031
nucleus localizationGO:005164710.031
cell projection organizationGO:00300302520.031
response to metal ionGO:0010038840.031
protein localization to nucleusGO:00345041360.030
morphogenesis of embryonic epitheliumGO:001633140.030
positive regulation of ion transportGO:0043270870.030
regulation of anatomical structure morphogenesisGO:00226032860.030
negative regulation of cellular protein metabolic processGO:00322693530.030
regulation of cell migrationGO:00303342890.030
single organism carbohydrate metabolic processGO:00447231930.029
cell developmentGO:00484683280.029
positive regulation of cell deathGO:00109422630.029
regulation of kinase activityGO:00435493140.029
eye photoreceptor cell differentiationGO:000175420.029
positive regulation of organelle organizationGO:00106381950.029
regulation of protein serine threonine kinase activityGO:00719001790.028
protein importGO:00170381300.028
positive regulation of cellular amine metabolic processGO:003324070.028
cell fate determinationGO:000170930.028
epithelium developmentGO:00604292270.028
protein targetingGO:00066051870.028
vesicle mediated transportGO:00161923710.028
nucleoside triphosphate metabolic processGO:00091414220.027
positive regulation of hydrolase activityGO:00513453310.027
cellular protein complex assemblyGO:00436231880.027
mitochondrion organizationGO:00070051560.026
guanosine containing compound metabolic processGO:19010682440.026
nucleocytoplasmic transportGO:00069131760.026
signal transduction by phosphorylationGO:00230142970.026
regulation of secretionGO:00510461940.026
peptidyl lysine modificationGO:00182051440.026
negative regulation of protein metabolic processGO:00512483910.026
establishment of protein localization to membraneGO:00901501210.025
cell divisionGO:00513011680.025
ion transmembrane transportGO:00342203380.025
posttranscriptional regulation of gene expressionGO:00106082130.025
organ morphogenesisGO:00098871470.025
pattern specification processGO:0007389430.025
mitochondrion distributionGO:004831130.025
regulation of nucleotide metabolic processGO:00061402690.025
regulation of secretion by cellGO:19035301770.025
anatomical structure homeostasisGO:00602491000.025
regulation of membrane potentialGO:0042391950.025
positive regulation of mapk cascadeGO:00434101900.025
protein import into nucleusGO:00066061040.024
positive regulation of cellular component biogenesisGO:00440891580.024
cellular response to dna damage stimulusGO:00069743790.024
taxisGO:00423301570.024
positive regulation of cell differentiationGO:00455972110.024
negative regulation of phosphorus metabolic processGO:00105632670.024
nuclear transportGO:00511691790.024
microtubule organizing center organizationGO:0031023620.024
microtubule polymerization or depolymerizationGO:0031109370.024
regulation of cytokine productionGO:00018172320.024
lung alveolus developmentGO:004828640.024
muscle structure developmentGO:0061061980.024
muscle organ developmentGO:0007517560.024
single organism nuclear importGO:19025931040.023
intracellular mrna localizationGO:000829810.023
negative regulation of cellular amino acid metabolic processGO:004576320.023
protein maturationGO:00516042330.023
centrosome organizationGO:0051297580.023
cellular lipid metabolic processGO:00442553030.023
protein polymerizationGO:0051258710.023
compound eye developmentGO:004874910.023
dephosphorylationGO:00163112090.023
regulation of nucleoside metabolic processGO:00091182090.023
cellular component disassemblyGO:0022411920.023
cell morphogenesisGO:00009022960.023
regulation of erk1 and erk2 cascadeGO:0070372990.022
organonitrogen compound biosynthetic processGO:19015662000.022
blastoderm segmentationGO:000735020.022
metal ion homeostasisGO:00550651690.022
regulation of multi organism processGO:00439001570.022
negative regulation of developmental processGO:00510932470.022
purine ribonucleotide biosynthetic processGO:0009152790.022
organophosphate biosynthetic processGO:00904071630.022
peripheral nervous system developmentGO:000742220.021
regulation of purine nucleotide catabolic processGO:00331212050.021
tube morphogenesisGO:0035239950.021
striated muscle cell differentiationGO:0051146430.021
positive regulation of gtp catabolic processGO:00331261660.021
protein localization to plasma membraneGO:0072659930.021
cell morphogenesis involved in differentiationGO:00009041440.020
ribose phosphate biosynthetic processGO:0046390820.020
secretionGO:00469032540.020
regulation of oocyte developmentGO:006028110.020
regulation of gtpase activityGO:00430871800.020
negative regulation of multicellular organismal processGO:00512413170.020
cation transportGO:00068123310.020
purine ribonucleoside monophosphate metabolic processGO:00091671860.020
rho protein signal transductionGO:0007266260.020
regulation of protein localization to plasma membraneGO:1903076400.020
regulation of purine nucleotide metabolic processGO:19005422640.020
neuromuscular junction developmentGO:000752830.020
monovalent inorganic cation transportGO:00156721280.020
regulation of synaptic plasticityGO:004816730.020
regulation of protein kinase activityGO:00458592890.020
cellular response to endogenous stimulusGO:00714953360.020
regulation of peptidase activityGO:00525471800.020
negative regulation of apoptotic processGO:00430663160.020
microtubule cytoskeleton organizationGO:00002261760.020
cellular response to oxygen containing compoundGO:19017012760.020
negative regulation of protein modification processGO:00314002000.020
positive regulation of cell migrationGO:00303351720.019
inorganic cation transmembrane transportGO:00986621940.019
regulation of cellular component sizeGO:0032535820.019
innate immune responseGO:00450871780.019
positive regulation of cell proliferationGO:00082843010.019
regulation of protein transportGO:00512232130.019
positive regulation of erk1 and erk2 cascadeGO:0070374750.019
protein processingGO:00164852260.019
phospholipid metabolic processGO:0006644990.019
synaptic vesicle endocytosisGO:004848820.019
inorganic ion transmembrane transportGO:00986602310.019
negative regulation of intracellular signal transductionGO:19025321830.019
negative regulation of hydrolase activityGO:00513461820.019
response to cytokineGO:00340972320.019
negative regulation of phosphorylationGO:00423261740.019
regulation of dna metabolic processGO:00510521530.018
cell part morphogenesisGO:00329901370.018
anion transportGO:00068201610.018
centrosome cycleGO:0007098320.018
engulfment of apoptotic cellGO:004365220.018
lipid metabolic processGO:00066293810.018
synaptic vesicle recyclingGO:003646530.018
negative regulation of proteolysisGO:00458611320.018
stress activated mapk cascadeGO:0051403930.018
regulation of protein maturationGO:19033171500.018
microtubule polymerizationGO:0046785180.018
protein modification by small protein conjugationGO:00324463420.018
regulation of neurotransmitter secretionGO:004692830.018
developmental maturationGO:0021700280.018
protein targeting to nucleusGO:00447441040.018
protein oligomerizationGO:00512591730.018
cell adhesionGO:00071553250.018
neuron developmentGO:00486661130.018
cellular carbohydrate metabolic processGO:0044262840.018
cell activationGO:00017752130.018
anatomical structure formation involved in morphogenesisGO:00486462840.018
chemical homeostasisGO:00488783060.018
negative regulation of peptidase activityGO:0010466910.018
positive regulation of secretion by cellGO:19035321080.018
rap protein signal transductionGO:003248670.018
embryonic epithelial tube formationGO:000183840.017
neuron differentiationGO:00301821380.017
biological adhesionGO:00226103310.017
cell projection assemblyGO:00300311260.017
cellular response to external stimulusGO:00714961110.017
carboxylic acid transportGO:0046942630.017
cardiovascular system developmentGO:00723582620.017
organic hydroxy compound metabolic processGO:19016151470.017
positive regulation of cell motilityGO:20001471770.017
purine nucleoside monophosphate metabolic processGO:00091261860.017
cellular chemical homeostasisGO:00550821800.017
spermatid differentiationGO:004851540.017
cellular homeostasisGO:00197251960.017
positive regulation of locomotionGO:00400171860.017
erk1 and erk2 cascadeGO:00703711040.017
response to external biotic stimulusGO:00432072610.017
positive regulation of cellular component movementGO:00512721810.017
regulation of intracellular transportGO:00323861950.017
purine containing compound biosynthetic processGO:0072522880.017
skeletal muscle fiber developmentGO:0048741120.017
head developmentGO:00603221080.017
response to inorganic substanceGO:00100351270.017
positive regulation of potassium ion transportGO:0043268150.017
organic anion transportGO:00157111030.016
sulfur compound metabolic processGO:00067901010.016
negative regulation of protein maturationGO:19033181420.016
establishment of protein localization to organelleGO:00725941720.016
regulation of ras gtpase activityGO:00323181280.016
detection of chemical stimulusGO:0009593550.016
positive regulation of cyclic nucleotide biosynthetic processGO:0030804380.016
nucleotide biosynthetic processGO:00091651090.016
positive regulation of immune system processGO:00026842830.016
osteoblast differentiationGO:0001649920.016
actin filament based processGO:00300292240.016
regulation of intracellular protein transportGO:00331571230.016
negative regulation of cell motilityGO:20001461040.016
endocytosisGO:00068971590.016
enzyme linked receptor protein signaling pathwayGO:00071673030.016
negative regulation of programmed cell deathGO:00430693210.016
blood vessel morphogenesisGO:00485141620.016
regulation of camp metabolic processGO:0030814520.015
carbohydrate derivative biosynthetic processGO:19011372070.015
lipid biosynthetic processGO:00086101770.015
negative regulation of cell cycle processGO:00109481210.015
regulation of cell morphogenesisGO:00226041530.015
camp metabolic processGO:0046058610.015
response to woundingGO:00096111680.015
negative regulation of transportGO:00510511760.015
myeloid cell differentiationGO:00300991170.015
cation homeostasisGO:00550801890.015
nucleoside monophosphate catabolic processGO:00091251590.015
atp metabolic processGO:00460341760.015
dna replicationGO:00062601160.015
neural tube formationGO:000184130.015
regulation of sequence specific dna binding transcription factor activityGO:00510902110.015
histone modificationGO:00165702510.015
defense responseGO:00069523150.015
regulation of metal ion transportGO:00109591200.015
epithelial cell proliferationGO:00506731280.015
immune effector processGO:00022521590.015
regenerationGO:003109940.014
regulation of map kinase activityGO:00434051080.014
positive regulation of nucleotide metabolic processGO:00459812300.014
stem cell divisionGO:001714520.014
establishment or maintenance of bipolar cell polarityGO:006124520.014
nerve developmentGO:002167540.014
cellular amide metabolic processGO:0043603690.014
peptide metabolic processGO:0006518510.014
negative regulation of cellular component organizationGO:00511292350.014
response to lipidGO:00339932060.014
regulation of ras protein signal transductionGO:00465781550.014
spermatid developmentGO:000728640.014
reactive oxygen species metabolic processGO:0072593750.014
response to abiotic stimulusGO:00096283360.014
tor signalingGO:0031929390.014
ossificationGO:00015031210.014
autophagyGO:0006914880.014
regulation of protein processingGO:00706131500.014
cyclic purine nucleotide metabolic processGO:0052652600.014
adult locomotory behaviorGO:000834410.014
endosomal transportGO:00161971290.014
chromatin organizationGO:00063253510.014
regulation of cyclic nucleotide metabolic processGO:0030799630.014
tissue regenerationGO:004224630.014
negative regulation of protein phosphorylationGO:00019331400.014
cytokinesisGO:0000910960.014
sequestering of metal ionGO:0051238240.013
central nervous system developmentGO:00074171230.013
generation of neuronsGO:00486991520.013
regulation of ion transportGO:00432691890.013
ion homeostasisGO:00508012300.013
secretion by cellGO:00329402260.013
positive regulation of cytokine productionGO:00018191670.013
positive regulation of ras gtpase activityGO:00323201170.013
cellular cation homeostasisGO:00300031630.013
hindbrain developmentGO:003090230.013
regulation of proteolysisGO:00301622930.013
hematopoietic or lymphoid organ developmentGO:00485341860.013
organic acid transportGO:0015849650.013
monocarboxylic acid metabolic processGO:00327871850.013
negative regulation of cell deathGO:00605483450.013
circulatory system developmentGO:00723592620.013
negative regulation of protein processingGO:00109551420.013
negative regulation of myotube differentiationGO:001083240.013
macromolecular complex disassemblyGO:0032984600.013
protein ubiquitinationGO:00165673140.013
regulation of neural precursor cell proliferationGO:200017740.013
lymphocyte activationGO:00466491330.013
actin mediated cell contractionGO:0070252120.013
regulation of cell activationGO:00508651250.013
replicative cell agingGO:000130230.013
anterior posterior axis specificationGO:000994820.013
regulation of neuronal synaptic plasticityGO:004816810.013
negative regulation of cell cycleGO:00457861930.013
positive regulation of protein transportGO:00512221350.013
cellular metal ion homeostasisGO:00068751460.013
embryo developmentGO:00097901230.013
rna interferenceGO:001624640.013
regulation of cellular component movementGO:00512703340.013
centrosome separationGO:005129930.013
regulation of endopeptidase activityGO:00525481700.013
organelle assemblyGO:00709251760.013
regulation of cytoplasmic transportGO:19036491490.013
exocytosisGO:0006887710.012
protein autophosphorylationGO:00467771230.012
immune system developmentGO:00025201950.012
myoblast fusionGO:000752010.012
cranial nerve developmentGO:002154540.012
regulation of anatomical structure sizeGO:00900661010.012
double strand break repairGO:00063021010.012
growthGO:00400072020.012
negative regulation of cell migrationGO:00303361020.012
positive regulation of protein modification by small protein conjugation or removalGO:1903322610.012
cerebellum developmentGO:002154920.012
ncrna metabolic processGO:00346601080.012
regulation of epithelial cell proliferationGO:00506781130.012
cytokine productionGO:00018162470.012
reproductive processGO:00224141060.012
positive regulation of neural precursor cell proliferationGO:200017920.012
positive regulation of jnk cascadeGO:0046330520.012
nuclear importGO:00511701060.012
ribonucleoside monophosphate metabolic processGO:00091611870.012
reactive oxygen species biosynthetic processGO:190340940.012
negative regulation of cellular catabolic processGO:0031330830.012
negative regulation of cellular component movementGO:00512711060.012
positive regulation of protein ubiquitinationGO:0031398530.012
cation transmembrane transportGO:00986552380.012
tube developmentGO:00352951250.012
negative regulation of synaptic transmissionGO:005080520.012
somitogenesisGO:000175620.012
fatty acid metabolic processGO:00066311150.012
atp catabolic processGO:00062001570.012
regulation of translationGO:0006417890.012
single organism cell adhesionGO:00986021790.012
regulation of protein kinase b signalingGO:0051896610.012
wnt signaling pathwayGO:00160551560.012
multicellular organismal homeostasisGO:0048871670.012
rhythmic behaviorGO:000762220.012
organelle localizationGO:0051640840.012
epithelial cell differentiationGO:00308551410.012
positive regulation of reactive oxygen species metabolic processGO:2000379240.011
somatic muscle developmentGO:000752510.011
cellular response to lipidGO:00713961270.011
response to biotic stimulusGO:00096072760.011
positive regulation of defense responseGO:0031349870.011
establishment of organelle localizationGO:0051656590.011
jnk cascadeGO:0007254800.011
synaptic transmission cholinergicGO:000727120.011
negative regulation of catabolic processGO:00098951040.011
organelle disassemblyGO:190300890.011
regulation of response to external stimulusGO:00321012220.011
positive regulation of immune responseGO:00507781590.011
syncytium formation by plasma membrane fusionGO:000076820.011
nitrogen compound transportGO:00717051910.011
cytoskeleton dependent intracellular transportGO:0030705210.011
inner ear morphogenesisGO:004247240.011
negative regulation of sequence specific dna binding transcription factor activityGO:0043433890.011
metencephalon developmentGO:002203720.011
response to bacteriumGO:00096171440.011
regulation of reactive oxygen species biosynthetic processGO:190342630.011
regulation of homeostatic processGO:00328441210.011
respiratory gaseous exchangeGO:000758530.011
regulation of angiogenesisGO:0045765920.011
oocyte differentiationGO:000999420.011
regulation of immune responseGO:00507762010.011
protein homooligomerizationGO:00512601000.011
cellular macromolecule catabolic processGO:00442653800.011
motor neuron axon guidanceGO:000804520.011
cyclic nucleotide metabolic processGO:0009187820.011
somatic stem cell maintenanceGO:003501940.011
ribonucleoside monophosphate catabolic processGO:00091581580.011
regulation of protein ubiquitinationGO:0031396950.011
immune response regulating signaling pathwayGO:0002764970.011
stress activated protein kinase signaling cascadeGO:0031098940.011
acrosomal vesicle exocytosisGO:006047830.011
positive regulation of cyclic nucleotide metabolic processGO:0030801490.011
negative regulation of kinase activityGO:00336731060.011
vasculature developmentGO:00019441810.011
alcohol metabolic processGO:00060661140.011
cell type specific apoptotic processGO:00972851250.011
chemotaxisGO:00069351570.011
negative regulation of wnt signaling pathwayGO:0030178690.011
negative regulation of cytokine productionGO:0001818820.011
receptor mediated endocytosisGO:0006898840.011
negative regulation of cell differentiationGO:00455961710.011
regulation of rho gtpase activityGO:0032319660.010
embryonic hemopoiesisGO:003516240.010
lymphocyte homeostasisGO:000226040.010
response to axon injuryGO:004867810.010
regulation of growthGO:00400081650.010
actin filament based movementGO:0030048170.010
positive regulation of kinase activityGO:00336742040.010
covalent chromatin modificationGO:00165692540.010
positive regulation of dna metabolic processGO:0051054730.010
ribonucleotide biosynthetic processGO:0009260810.010
camp biosynthetic processGO:0006171470.010
methylationGO:00322591060.010
tube closureGO:006060630.010
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.010
purine ribonucleoside monophosphate catabolic processGO:00091691580.010
negative regulation of locomotionGO:00400131180.010
angiogenesisGO:00015251470.010
microtubule based movementGO:0007018320.010
mitotic cell cycleGO:00002783260.010

KCNE3 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
central nervous system diseaseDOID:3311860.058
nervous system diseaseDOID:8634310.058
disease of cellular proliferationDOID:145661740.037
disease of metabolismDOID:00146672950.034
inherited metabolic disorderDOID:6552420.034
organ system cancerDOID:00506861640.030
cancerDOID:1621670.030
sensory system diseaseDOID:00501552030.027
musculoskeletal system diseaseDOID:172230.027
connective tissue diseaseDOID:651090.023
cardiovascular system diseaseDOID:12871060.021
eye and adnexa diseaseDOID:14921500.019
eye diseaseDOID:56141490.017
bone diseaseDOID:0080001880.014
muscular diseaseDOID:00800001140.014
muscle tissue diseaseDOID:661130.013
endocrine gland cancerDOID:170260.012
neurodegenerative diseaseDOID:12891020.010