Homo sapiens

138 known processes

KCNE1

potassium voltage-gated channel, Isk-related family, member 1

(Aliases: LQT5,MinK,JLNS2,FLJ38123,FLJ18426,ISK,LQT2/5,MGC33114,FLJ94103,JLNS)

KCNE1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of atrial cardiac muscle cell membrane repolarizationGO:006037241.000
positive regulation of digestive system processGO:006045621.000
regulation of potassium ion transmembrane transportGO:1901379200.998
cardiac muscle cell contractionGO:008600340.997
potassium ion transmembrane transportGO:0071805600.995
cardiac muscle cell action potentialGO:0086001230.993
potassium ion transportGO:0006813620.992
regulation of cardiac muscle contractionGO:0055117330.991
cardiac muscle cell action potential involved in contractionGO:0086002210.990
membrane repolarization during action potentialGO:008601180.988
cellular response to campGO:0071320210.973
striated muscle contractionGO:0006941520.969
muscle contractionGO:0006936730.968
cardiac muscle contractionGO:0060048340.968
actin filament based movementGO:0030048170.968
actin mediated cell contractionGO:0070252120.957
inorganic ion transmembrane transportGO:00986602310.950
muscle system processGO:0003012810.936
membrane repolarizationGO:0086009230.934
regulation of cardiac muscle cell contractionGO:0086004230.928
ion transmembrane transportGO:00342203380.924
regulation of heart contractionGO:0008016500.921
regulation of muscle system processGO:0090257530.911
genetic imprintingGO:007151410.910
regulation of potassium ion transportGO:0043266240.907
regulation of muscle contractionGO:0006937450.874
transmembrane transportGO:00550853990.874
cation transmembrane transportGO:00986552380.874
regulation of striated muscle contractionGO:0006942370.873
positive regulation of potassium ion transmembrane transportGO:1901381120.871
positive regulation of ion transmembrane transportGO:0034767400.865
regulation of heart rateGO:0002027380.851
cation transportGO:00068123310.850
monovalent inorganic cation transportGO:00156721280.844
regulation of actin filament based movementGO:1903115240.831
regulation of blood circulationGO:1903522590.828
cardiac conductionGO:0061337230.814
regulation of heart rate by cardiac conductionGO:0086091190.809
response to campGO:0051591250.804
regulation of system processGO:00440571010.796
positive regulation of transmembrane transportGO:0034764410.774
action potentialGO:0001508340.772
cell communication involved in cardiac conductionGO:0086065180.756
ventricular cardiac muscle cell action potentialGO:0086005150.751
digestionGO:0007586220.734
heart contractionGO:0060047620.727
multicellular organismal signalingGO:0035637340.720
regulation of digestive system processGO:004405850.714
peptide secretionGO:0002790510.711
regulation of ion transportGO:00432691890.698
regulation of metal ion transportGO:00109591200.686
heart processGO:0003015620.670
negative regulation of peptide hormone secretionGO:0090278100.643
blood circulationGO:00080151130.631
regulation of peptide hormone secretionGO:0090276410.613
acid secretionGO:0046717120.610
regulation of hormone secretionGO:0046883570.603
regulation of secretion by cellGO:19035301770.595
regulation of secretionGO:00510461940.544
negative regulation of secretionGO:0051048580.533
positive regulation of secretionGO:00510471160.524
response to organophosphorusGO:0046683410.499
response to purine containing compoundGO:0014074400.496
atrial cardiac muscle cell to av node cell communicationGO:008606660.492
negative regulation of secretion by cellGO:1903531520.485
positive regulation of transportGO:00510503360.475
cellular response to endogenous stimulusGO:00714953360.470
secretionGO:00469032540.447
circulatory system processGO:00030131130.438
negative regulation of insulin secretionGO:004667690.437
actin filament based processGO:00300292240.433
system processGO:00030083490.433
negative regulation of transportGO:00510511760.427
regulation of cellular component movementGO:00512703340.408
regulation of hormone levelsGO:00108171250.398
peptide transportGO:0015833740.389
hormone secretionGO:0046879650.376
secretion by cellGO:00329402260.367
cellular response to nitrogen compoundGO:19016991440.354
peptide hormone secretionGO:0030072500.344
cellular response to organonitrogen compoundGO:00714171240.333
negative regulation of peptide secretionGO:0002792110.318
insulin secretionGO:0030073390.309
response to organic cyclic compoundGO:00140702040.304
hormone transportGO:0009914680.289
amide transportGO:0042886760.279
nitrogen compound transportGO:00717051910.278
male sex differentiationGO:0046661250.256
signal releaseGO:0023061700.247
regulation of insulin secretionGO:0050796330.233
response to nitrogen compoundGO:19016981840.214
male gonad developmentGO:0008584230.210
gene silencingGO:0016458490.197
cell cell signalingGO:00072671550.189
response to organonitrogen compoundGO:00102431560.184
regulation of peptide secretionGO:0002791420.145
response to oxygen containing compoundGO:19017003690.142
atrial cardiac muscle cell action potentialGO:008601460.141
circulatory system developmentGO:00723592620.130
response to drugGO:0042493810.123
cellular response to drugGO:0035690270.114
regulation of cellular ketone metabolic processGO:0010565500.107
cardiovascular system developmentGO:00723582620.104
cell cell signaling involved in cardiac conductionGO:008601990.102
chemical homeostasisGO:00488783060.097
cellular amine metabolic processGO:0044106410.095
defense responseGO:00069523150.093
amine metabolic processGO:0009308440.089
regulation of gene expression epigeneticGO:0040029730.084
immune responseGO:00069553070.083
positive regulation of cellular amine metabolic processGO:003324070.081
response to other organismGO:00517072610.079
ion homeostasisGO:00508012300.079
regulation of cell cycleGO:00517263930.076
metal ion transportGO:00300012720.069
lipid metabolic processGO:00066293810.069
positive regulation of cellular amino acid metabolic processGO:004576430.067
regulation of locomotionGO:00400123290.066
vesicle mediated transportGO:00161923710.064
metal ion homeostasisGO:00550651690.063
post embryonic developmentGO:000979120.062
anion transportGO:00068201610.061
response to abiotic stimulusGO:00096283360.059
monocarboxylic acid metabolic processGO:00327871850.058
neurological system processGO:00508771630.052
response to lipidGO:00339932060.051
cation homeostasisGO:00550801890.051
cytokine productionGO:00018162470.050
response to biotic stimulusGO:00096072760.049
reproductive processGO:00224141060.048
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187430.048
negative regulation of protein metabolic processGO:00512483910.047
cellular lipid metabolic processGO:00442553030.045
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188430.045
regulation of protein transportGO:00512232130.045
cellular response to oxygen containing compoundGO:19017012760.044
regulation of proteolysisGO:00301622930.043
purine ribonucleoside metabolic processGO:00461284370.043
cellular cation homeostasisGO:00300031630.043
positive regulation of developmental processGO:00510943140.042
inorganic cation transmembrane transportGO:00986621940.042
adenylate cyclase inhibiting serotonin receptor signaling pathwayGO:000719820.041
nervous system developmentGO:00073992930.041
regulation of mapk cascadeGO:00434082620.041
anatomical structure formation involved in morphogenesisGO:00486462840.041
regulation of response to external stimulusGO:00321012220.041
multicellular organismal agingGO:001025930.041
carbohydrate derivative biosynthetic processGO:19011372070.040
divalent inorganic cation transportGO:00725111580.040
response to external biotic stimulusGO:00432072610.040
positive regulation of cytosolic calcium ion concentrationGO:0007204820.039
single organism reproductive processGO:0044702980.039
g protein coupled receptor signaling pathwayGO:00071862070.039
regulation of cytokine productionGO:00018172320.039
sensory perceptionGO:00076001030.039
negative regulation of programmed cell deathGO:00430693210.038
regulation of establishment of protein localizationGO:00702012420.038
purine containing compound catabolic processGO:00725234110.037
biological adhesionGO:00226103310.037
positive regulation of ion transportGO:0043270870.037
cellular ion homeostasisGO:00068731680.036
purine nucleoside triphosphate metabolic processGO:00091444120.036
regulation of cellular amino acid metabolic processGO:000652160.036
negative regulation of phosphorus metabolic processGO:00105632670.035
lipid catabolic processGO:0016042840.035
ribonucleotide catabolic processGO:00092614050.035
cellular chemical homeostasisGO:00550821800.034
determination of adult lifespanGO:000834020.034
response to hormoneGO:00097251750.034
atrial cardiac muscle cell to av node cell signalingGO:008602660.034
regulation of gene expression by genetic imprintingGO:000634910.034
protein catabolic processGO:00301633250.034
immune effector processGO:00022521590.033
positive regulation of catabolic processGO:00098963100.033
regulation of cell motilityGO:20001452990.033
negative regulation of apoptotic processGO:00430663160.033
sensory perception of painGO:001923340.032
vasculature developmentGO:00019441810.032
cellular macromolecule catabolic processGO:00442653800.032
positive regulation of cell differentiationGO:00455972110.032
negative regulation of cellular protein metabolic processGO:00322693530.032
memoryGO:000761330.032
cellular component morphogenesisGO:00329893140.032
purine ribonucleoside triphosphate metabolic processGO:00092054110.031
sex differentiationGO:0007548450.031
epithelium developmentGO:00604292270.030
regulation of nucleotide metabolic processGO:00061402690.030
small molecule biosynthetic processGO:00442831570.030
purine ribonucleoside triphosphate catabolic processGO:00092073910.030
cellular metal ion homeostasisGO:00068751460.030
nucleotide biosynthetic processGO:00091651090.030
innate immune responseGO:00450871780.030
cyclic nucleotide biosynthetic processGO:0009190610.030
ribose phosphate biosynthetic processGO:0046390820.030
regulation of cellular amine metabolic processGO:0033238110.029
locomotory behaviorGO:000762610.029
adenylate cyclase inhibiting adrenergic receptor signaling pathwayGO:007188110.029
organic hydroxy compound metabolic processGO:19016151470.029
nucleoside phosphate catabolic processGO:19012924120.029
regulation of cell migrationGO:00303342890.029
nucleoside triphosphate catabolic processGO:00091433940.028
regulation of multi organism processGO:00439001570.028
cellular amino acid metabolic processGO:00065201160.028
regulation of cell cycle processGO:00105642660.028
negative regulation of developmental processGO:00510932470.028
segmentationGO:003528240.028
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.028
nucleoside catabolic processGO:00091644080.028
purine ribonucleotide biosynthetic processGO:0009152790.027
cyclic nucleotide metabolic processGO:0009187820.027
protein maturationGO:00516042330.027
organophosphate catabolic processGO:00464344300.027
regulation of immune effector processGO:0002697910.027
nucleoside triphosphate metabolic processGO:00091414220.027
regulation of kinase activityGO:00435493140.027
negative regulation of insulin secretion involved in cellular response to glucose stimulusGO:006117910.027
negative regulation of cell proliferationGO:00082852280.026
cell morphogenesisGO:00009022960.026
signal transduction by phosphorylationGO:00230142970.026
positive regulation of hydrolase activityGO:00513453310.026
mitotic cell cycle processGO:19030472860.026
purine nucleotide catabolic processGO:00061954050.026
regulation of immune responseGO:00507762010.026
cellular ketone metabolic processGO:0042180800.026
development of primary sexual characteristicsGO:0045137350.026
camp metabolic processGO:0046058610.025
regulation of nucleotide biosynthetic processGO:0030808500.025
cyclic purine nucleotide metabolic processGO:0052652600.025
regulation of cellular component biogenesisGO:00440872810.025
regulation of protein serine threonine kinase activityGO:00719001790.025
cellular response to hormone stimulusGO:00328701250.025
purine containing compound biosynthetic processGO:0072522880.025
purine ribonucleoside monophosphate metabolic processGO:00091671860.025
alcohol metabolic processGO:00060661140.025
positive regulation of nucleotide metabolic processGO:00459812300.025
neuromuscular junction developmentGO:000752830.024
positive regulation of immune system processGO:00026842830.024
blood vessel developmentGO:00015681720.024
regulation of transferase activityGO:00513383550.024
female gamete generationGO:000729220.024
single organism cellular localizationGO:19025803320.024
regulation of camp metabolic processGO:0030814520.024
single organism membrane organizationGO:00448022680.024
small gtpase mediated signal transductionGO:0007264780.024
morphogenesis of embryonic epitheliumGO:001633140.024
regulation of camp biosynthetic processGO:0030817450.024
circadian behaviorGO:004851220.023
camp biosynthetic processGO:0006171470.023
ras protein signal transductionGO:0007265730.023
protein secretionGO:0009306980.023
ribonucleoside triphosphate catabolic processGO:00092033910.023
positive regulation of cell cycleGO:00457871400.023
regulation of protein catabolic processGO:00421761550.023
ribonucleoside monophosphate metabolic processGO:00091611870.023
negative regulation of ion transportGO:0043271390.023
positive regulation of secretion by cellGO:19035321080.022
small molecule catabolic processGO:0044282920.022
regulation of purine nucleotide catabolic processGO:00331212050.022
ossificationGO:00015031210.022
cellular response to organic cyclic compoundGO:00714071270.022
regulation of cyclic nucleotide metabolic processGO:0030799630.022
negative regulation of hydrolase activityGO:00513461820.022
positive regulation of proteolysisGO:00458621420.022
potassium ion importGO:001010790.022
negative regulation of cellular amine metabolic processGO:003323930.022
nucleoside monophosphate catabolic processGO:00091251590.021
negative regulation of intracellular signal transductionGO:19025321830.021
cellular calcium ion homeostasisGO:00068741170.021
regulation of membrane potentialGO:0042391950.021
purine nucleoside monophosphate metabolic processGO:00091261860.021
peptidyl tyrosine phosphorylationGO:00181081700.021
hematopoietic or lymphoid organ developmentGO:00485341860.021
negative regulation of response to external stimulusGO:0032102830.021
membrane organizationGO:00610242920.021
regenerationGO:003109940.021
negative regulation of catalytic activityGO:00430863350.021
carbohydrate metabolic processGO:00059752070.020
regulation of peptidase activityGO:00525471800.020
purine ribonucleoside monophosphate catabolic processGO:00091691580.020
gonad developmentGO:0008406340.020
regulation of synaptic plasticityGO:004816730.020
negative regulation of phosphate metabolic processGO:00459362670.020
negative regulation of cell cycleGO:00457861930.020
cell developmentGO:00484683280.019
carboxylic acid biosynthetic processGO:0046394970.019
myeloid cell differentiationGO:00300991170.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
atp metabolic processGO:00460341760.019
positive regulation of cellular component organizationGO:00511303760.019
cellular response to dna damage stimulusGO:00069743790.019
response to oxygen levelsGO:00704821000.019
hormone metabolic processGO:0042445610.019
cell projection organizationGO:00300302520.019
atp catabolic processGO:00062001570.019
cytokine secretionGO:0050663640.019
proteolysis involved in cellular protein catabolic processGO:00516032440.019
regulation of dna metabolic processGO:00510521530.019
purine ribonucleotide catabolic processGO:00091544040.019
cell activationGO:00017752130.018
regulation of cyclic nucleotide biosynthetic processGO:0030802490.018
regulation of calcium ion transportGO:0051924790.018
cellular potassium ion transportGO:0071804600.018
oogenesisGO:004847720.018
circadian sleep wake cycle processGO:002241020.018
response to hypoxiaGO:0001666960.018
ribonucleoside catabolic processGO:00424544060.018
positive regulation of cyclic nucleotide biosynthetic processGO:0030804380.018
peripheral nervous system developmentGO:000742220.018
growthGO:00400072020.018
cellular response to cytokine stimulusGO:00713451810.018
regulation of body fluid levelsGO:0050878990.018
proteasomal protein catabolic processGO:00104981760.018
positive regulation of synaptic transmissionGO:005080640.018
response to axon injuryGO:004867810.018
protein processingGO:00164852260.017
peptidyl tyrosine modificationGO:00182121700.017
cytoplasmic transportGO:00164823790.017
adenylate cyclase activating dopamine receptor signaling pathwayGO:000719130.017
reproductive structure developmentGO:0048608550.017
protein ubiquitinationGO:00165673140.017
regulation of nucleoside metabolic processGO:00091182090.017
endomembrane system organizationGO:00102561960.017
positive regulation of camp biosynthetic processGO:0030819350.017
sequestering of calcium ionGO:0051208170.017
carboxylic acid transportGO:0046942630.017
divalent inorganic cation homeostasisGO:00725071360.017
angiogenesisGO:00015251470.017
positive regulation of phosphorylationGO:00423273940.017
oocyte differentiationGO:000999420.017
blood vessel morphogenesisGO:00485141620.017
reactive oxygen species biosynthetic processGO:190340940.017
purine nucleoside triphosphate catabolic processGO:00091463920.017
regulation of intracellular transportGO:00323861950.017
nucleotide catabolic processGO:00091664080.017
regulation of protein processingGO:00706131500.017
positive regulation of programmed cell deathGO:00430682490.017
adenylate cyclase inhibiting g protein coupled receptor signaling pathwayGO:0007193220.017
hemopoiesisGO:00300971800.017
leukocyte activationGO:00453211640.017
cellular protein catabolic processGO:00442572610.017
second messenger mediated signalingGO:0019932780.017
sodium ion transportGO:0006814610.017
response to growth factorGO:00708482050.017
matingGO:000761810.017
embryonic epithelial tube formationGO:000183840.016
regulation of protein kinase activityGO:00458592890.016
sleepGO:003043120.016
cellular macromolecular complex assemblyGO:00346223240.016
regulation of cell growthGO:00015581350.016
regulation of ion transmembrane transportGO:00347651320.016
defense response to bacteriumGO:0042742630.016
visual behaviorGO:000763220.016
compound eye developmentGO:004874910.016
positive regulation of kinase activityGO:00336742040.016
dephosphorylationGO:00163112090.016
positive regulation of phosphatidylinositol biosynthetic processGO:001051330.016
head developmentGO:00603221080.016
cellular component disassemblyGO:0022411920.016
maintenance of locationGO:00512351120.016
multicellular organismal homeostasisGO:0048871670.016
response to salt stressGO:000965130.016
regulation of transmembrane transportGO:00347621390.016
guanosine containing compound metabolic processGO:19010682440.016
glycerolipid metabolic processGO:00464861070.016
developmental programmed cell deathGO:001062330.016
purine ribonucleoside catabolic processGO:00461303980.016
gtp metabolic processGO:00460392390.016
phospholipid metabolic processGO:0006644990.016
ribonucleoside monophosphate catabolic processGO:00091581580.016
guanosine containing compound catabolic processGO:19010692390.016
organic anion transportGO:00157111030.016
calcium ion homeostasisGO:00550741220.016
negative regulation of wnt protein secretionGO:006135810.016
regulation of protein localizationGO:00328802960.016
organelle assemblyGO:00709251760.016
neural tube formationGO:000184130.016
modification dependent protein catabolic processGO:00199412090.015
positive regulation of protein kinase activityGO:00458601900.015
cell growthGO:00160491600.015
nerve developmentGO:002167540.015
central nervous system developmentGO:00074171230.015
cytosolic calcium ion homeostasisGO:0051480890.015
neuroblast proliferationGO:000740540.015
cannabinoid signaling pathwayGO:003817120.015
forebrain generation of neuronsGO:002187230.015
motor neuron axon guidanceGO:000804520.015
thymus developmentGO:004853830.015
regulation of blood volume by renin angiotensinGO:000201610.015
response to inorganic substanceGO:00100351270.015
response to cytokineGO:00340972320.015
cellular amide metabolic processGO:0043603690.015
positive regulation of cell motilityGO:20001471770.015
tripartite regional subdivisionGO:000735120.015
negative regulation of catabolic processGO:00098951040.015
mitochondrion organizationGO:00070051560.015
positive regulation of erk1 and erk2 cascadeGO:0070374750.015
regulation of circadian sleep wake cycle sleepGO:004518720.015
myeloid leukocyte differentiationGO:0002573600.014
chromatin organizationGO:00063253510.014
negative regulation of protein modification processGO:00314002000.014
lipid transportGO:0006869900.014
positive regulation of organic acid transportGO:003289230.014
regulation of vesicle mediated transportGO:00606271300.014
negative regulation of organelle organizationGO:00106391260.014
reactive nitrogen species metabolic processGO:200105730.014
sulfur compound metabolic processGO:00067901010.014
developmental process involved in reproductionGO:0003006660.014
protein localization to organelleGO:00333652800.014
regulation of cell adhesionGO:00301551660.014
positive regulation of nucleoside metabolic processGO:00459791860.014
sodium ion transmembrane transportGO:0035725590.014
anatomical structure homeostasisGO:00602491000.014
anion transmembrane transportGO:0098656760.014
negative regulation of voltage gated calcium channel activityGO:190138640.014
mitotic cell cycleGO:00002783260.014
organic acid catabolic processGO:0016054710.014
single organism carbohydrate metabolic processGO:00447231930.014
regulation of bindingGO:00510981110.014
heart developmentGO:0007507950.014
regulation of protein complex assemblyGO:00432541470.014
glycoprotein metabolic processGO:00091001100.014
multicellular organismal response to stressGO:003355510.014
metencephalon developmentGO:002203720.014
cartilage condensationGO:000150210.014
positive regulation of protein phosphorylationGO:00019343130.014
negative regulation of peptidase activityGO:0010466910.014
protein oligomerizationGO:00512591730.014
negative regulation of protein phosphorylationGO:00019331400.014
regulation of innate immune responseGO:0045088970.014
regulation of neural precursor cell proliferationGO:200017740.014
cell cycle phase transitionGO:00447701730.014
regulation of cyclase activityGO:0031279190.014
positive regulation of blood pressureGO:004577730.014
glycosyl compound catabolic processGO:19016584130.014
vasodilationGO:004231140.014
regulation of cytoplasmic transportGO:19036491490.014
epithelial cell migrationGO:00106311190.014
response to fungusGO:000962040.014
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.014
regulation of protein stabilityGO:0031647870.014
cellular lipid catabolic processGO:0044242650.014
negative regulation of blood pressureGO:004577630.013
response to virusGO:00096151260.013
regulation of sequence specific dna binding transcription factor activityGO:00510902110.013
positive regulation of immune responseGO:00507781590.013
circadian sleep wake cycleGO:004274520.013
negative regulation of growthGO:0045926970.013
regulation of cell developmentGO:00602841610.013
response to alcoholGO:0097305640.013
associative learningGO:000830610.013
response to woundingGO:00096111680.013
spermatid differentiationGO:004851540.013
nucleoside monophosphate metabolic processGO:00091231910.013
intracellular protein transportGO:00068862700.013
lipid localizationGO:00108761060.013
calcium ion transportGO:00068161470.013
inner ear morphogenesisGO:004247240.013
renal tubular secretionGO:009725410.013
response to steroid hormoneGO:0048545800.013
cellular divalent inorganic cation homeostasisGO:00725031280.013
regulation of feeding behaviorGO:006025930.013
visual learningGO:000854210.013
positive regulation of protein catabolic processGO:0045732750.013
micturitionGO:006007330.013

KCNE1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
cardiovascular system diseaseDOID:12871060.967
familial atrial fibrillationDOID:0050650100.492
heart conduction diseaseDOID:10273180.492
disease of metabolismDOID:00146672950.052
nervous system diseaseDOID:8634310.041
sensory system diseaseDOID:00501552030.041
urinary system diseaseDOID:18400.036
kidney diseaseDOID:557360.036
renal tubular transport diseaseDOID:447110.036
eye and adnexa diseaseDOID:14921500.026
eye diseaseDOID:56141490.026
central nervous system diseaseDOID:3311860.023
cancerDOID:1621670.020
disease of cellular proliferationDOID:145661740.020
connective tissue diseaseDOID:651090.020
bone diseaseDOID:0080001880.020
musculoskeletal system diseaseDOID:172230.020
retinal diseaseDOID:56791180.019
primary ciliary dyskinesiaDOID:9562270.018
night blindnessDOID:8499100.017
congenital stationary night blindnessDOID:005053480.017
disease of mental healthDOID:150700.017
organ system cancerDOID:00506861640.016
immune system diseaseDOID:29141550.015
muscular diseaseDOID:00800001140.015
muscle tissue diseaseDOID:661130.015
inherited metabolic disorderDOID:6552420.014
neurodegenerative diseaseDOID:12891020.014
myopathyDOID:4231040.014