Homo sapiens

0 known processes

ZSWIM6

zinc finger, SWIM-type containing 6

(Aliases: KIAA1577,DKFZp779P0344)

ZSWIM6 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amine metabolic processGO:0044106410.133
amine metabolic processGO:0009308440.130
post embryonic developmentGO:000979120.110
ras protein signal transductionGO:0007265730.102
female gamete generationGO:000729220.094
regulation of cellular amino acid metabolic processGO:000652160.090
nucleoside catabolic processGO:00091644080.089
cellular ketone metabolic processGO:0042180800.085
small gtpase mediated signal transductionGO:0007264780.082
cellular amino acid metabolic processGO:00065201160.081
regulation of cellular amine metabolic processGO:0033238110.076
regulation of cellular ketone metabolic processGO:0010565500.075
nucleotide catabolic processGO:00091664080.074
ribonucleotide catabolic processGO:00092614050.067
purine ribonucleoside catabolic processGO:00461303980.064
positive regulation of cellular amino acid metabolic processGO:004576430.064
regulation of cell differentiationGO:00455953930.063
Mouse
organophosphate catabolic processGO:00464344300.062
cellular component morphogenesisGO:00329893140.061
Mouse
regulation of locomotionGO:00400123290.061
Mouse
nucleoside phosphate catabolic processGO:19012924120.060
oogenesisGO:004847720.059
purine ribonucleotide catabolic processGO:00091544040.059
purine nucleoside triphosphate metabolic processGO:00091444120.058
cell developmentGO:00484683280.057
Mouse
determination of adult lifespanGO:000834020.055
purine containing compound catabolic processGO:00725234110.055
vesicle mediated transportGO:00161923710.055
purine nucleotide catabolic processGO:00061954050.054
purine ribonucleoside metabolic processGO:00461284370.053
nucleoside triphosphate catabolic processGO:00091433940.053
regulation of nucleotide catabolic processGO:00308112050.053
ribonucleoside triphosphate catabolic processGO:00092033910.053
purine ribonucleoside triphosphate metabolic processGO:00092054110.052
actin filament based processGO:00300292240.052
purine nucleoside catabolic processGO:00061523980.051
gtp metabolic processGO:00460392390.051
glycosyl compound catabolic processGO:19016584130.051
regulation of cellular component movementGO:00512703340.050
Mouse
multicellular organismal agingGO:001025930.050
lipid metabolic processGO:00066293810.049
cell morphogenesisGO:00009022960.049
Mouse
positive regulation of cellular amine metabolic processGO:003324070.048
ribonucleoside triphosphate metabolic processGO:00091994120.048
guanosine containing compound catabolic processGO:19010692390.048
positive regulation of catabolic processGO:00098963100.046
biological adhesionGO:00226103310.046
positive regulation of gtpase activityGO:00435471660.046
regulation of transferase activityGO:00513383550.045
ribonucleoside catabolic processGO:00424544060.045
negative regulation of cellular protein metabolic processGO:00322693530.045
nervous system developmentGO:00073992930.044
Mouse
negative regulation of protein metabolic processGO:00512483910.044
positive regulation of cellular catabolic processGO:00313312840.044
regulation of cell motilityGO:20001452990.044
Mouse
regulation of cell migrationGO:00303342890.044
Mouse
gtp catabolic processGO:00061842370.044
purine nucleoside triphosphate catabolic processGO:00091463920.044
cytoplasmic transportGO:00164823790.043
nucleoside triphosphate metabolic processGO:00091414220.043
regulation of purine nucleotide metabolic processGO:19005422640.043
regulation of kinase activityGO:00435493140.042
response to oxygen containing compoundGO:19017003690.042
negative regulation of cellular amine metabolic processGO:003323930.042
response to abiotic stimulusGO:00096283360.042
compound eye developmentGO:004874910.042
regulation of gtp catabolic processGO:00331241800.042
protein modification by small protein conjugationGO:00324463420.041
immune responseGO:00069553070.041
negative regulation of catalytic activityGO:00430863350.041
regulation of anatomical structure morphogenesisGO:00226032860.041
purine ribonucleoside triphosphate catabolic processGO:00092073910.041
rho protein signal transductionGO:0007266260.040
regulation of nucleoside metabolic processGO:00091182090.040
positive regulation of phosphorylationGO:00423273940.040
guanosine containing compound metabolic processGO:19010682440.040
cell adhesionGO:00071553250.040
transmembrane transportGO:00550853990.039
negative regulation of multicellular organismal processGO:00512413170.039
cell projection organizationGO:00300302520.038
Mouse
regulation of nucleotide metabolic processGO:00061402690.038
protein ubiquitinationGO:00165673140.038
system processGO:00030083490.038
cellular response to endogenous stimulusGO:00714953360.038
positive regulation of protein phosphorylationGO:00019343130.037
regulation of cellular component biogenesisGO:00440872810.036
regulation of purine nucleotide catabolic processGO:00331212050.036
positive regulation of hydrolase activityGO:00513453310.036
cellular macromolecule catabolic processGO:00442653800.036
regulation of protein kinase activityGO:00458592890.035
positive regulation of nucleoside metabolic processGO:00459791860.035
positive regulation of nucleotide metabolic processGO:00459812300.035
locomotory behaviorGO:000762610.034
cellular response to oxygen containing compoundGO:19017012760.033
dephosphorylationGO:00163112090.033
response to growth factorGO:00708482050.033
mitotic cell cycleGO:00002783260.033
positive regulation of cellular component organizationGO:00511303760.033
negative regulation of cellular amino acid metabolic processGO:004576320.032
positive regulation of transportGO:00510503360.032
single organism cellular localizationGO:19025803320.032
mapk cascadeGO:00001652880.032
regulation of cell cycleGO:00517263930.031
reactive nitrogen species metabolic processGO:200105730.031
metal ion transportGO:00300012720.031
secretionGO:00469032540.031
regulation of protein serine threonine kinase activityGO:00719001790.030
positive regulation of gtp catabolic processGO:00331261660.030
regulation of ras protein signal transductionGO:00465781550.030
negative regulation of phosphorus metabolic processGO:00105632670.030
positive regulation of nucleotide catabolic processGO:00308131850.030
neuromuscular junction developmentGO:000752830.030
secretion by cellGO:00329402260.030
mitotic cell cycle processGO:19030472860.029
actin cytoskeleton organizationGO:00300362070.029
oocyte differentiationGO:000999420.029
cellular lipid metabolic processGO:00442553030.029
membrane organizationGO:00610242920.029
reactive oxygen species biosynthetic processGO:190340940.029
segmentationGO:003528240.029
positive regulation of purine nucleotide catabolic processGO:00331231850.029
positive regulation of purine nucleotide metabolic processGO:19005442270.028
regulation of small gtpase mediated signal transductionGO:00510561560.028
negative regulation of phosphate metabolic processGO:00459362670.028
regenerationGO:003109940.027
single organism membrane organizationGO:00448022680.027
negative regulation of programmed cell deathGO:00430693210.027
ion transmembrane transportGO:00342203380.027
regulation of protein localizationGO:00328802960.027
motor neuron axon guidanceGO:000804520.027
enzyme linked receptor protein signaling pathwayGO:00071673030.027
regulation of mapk cascadeGO:00434082620.027
chemical homeostasisGO:00488783060.027
regulation of gtpase activityGO:00430871800.027
epithelium developmentGO:00604292270.027
regulation of reactive oxygen species biosynthetic processGO:190342630.026
cation transportGO:00068123310.026
negative regulation of cellular component organizationGO:00511292350.026
protein localization to organelleGO:00333652800.026
positive regulation of mapk cascadeGO:00434101900.026
cell morphogenesis involved in differentiationGO:00009041440.026
regulation of cellular response to stressGO:00801352440.026
cellular response to growth factor stimulusGO:00713631970.025
neurogenesisGO:00220081690.025
Mouse
negative regulation of cell deathGO:00605483450.025
negative regulation of apoptotic processGO:00430663160.025
positive regulation of ras gtpase activityGO:00323201170.025
defense responseGO:00069523150.025
positive regulation of locomotionGO:00400171860.025
oocyte developmentGO:004859910.025
negative regulation of protein modification processGO:00314002000.025
hindbrain developmentGO:003090230.025
generation of neuronsGO:00486991520.024
Mouse
reactive oxygen species metabolic processGO:0072593750.024
inorganic ion transmembrane transportGO:00986602310.024
positive regulation of developmental processGO:00510943140.024
wnt signaling pathwayGO:00160551560.024
maintenance of locationGO:00512351120.024
single organism cell adhesionGO:00986021790.024
posttranscriptional regulation of gene expressionGO:00106082130.024
positive regulation of transferase activityGO:00513472270.023
memoryGO:000761330.023
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.023
organonitrogen compound biosynthetic processGO:19015662000.023
cell projection morphogenesisGO:00488581290.023
Mouse
nerve developmentGO:002167540.023
cellular protein catabolic processGO:00442572610.023
neurological system processGO:00508771630.023
immune system developmentGO:00025201950.023
endosomal transportGO:00161971290.023
positive regulation of kinase activityGO:00336742040.023
positive regulation of cell deathGO:00109422630.023
regulation of cytokine productionGO:00018172320.023
protein catabolic processGO:00301633250.022
intracellular protein transportGO:00068862700.022
response to other organismGO:00517072610.022
cellular macromolecular complex assemblyGO:00346223240.022
anatomical structure formation involved in morphogenesisGO:00486462840.022
regulation of growthGO:00400081650.022
proteolysis involved in cellular protein catabolic processGO:00516032440.022
growthGO:00400072020.022
cytokine productionGO:00018162470.022
positive regulation of cell proliferationGO:00082843010.022
neuron projection developmentGO:00311751060.022
Mouse
negative regulation of developmental processGO:00510932470.022
small molecule biosynthetic processGO:00442831570.022
protein processingGO:00164852260.021
chemotaxisGO:00069351570.021
regulation of protein transportGO:00512232130.021
ion homeostasisGO:00508012300.021
signal transduction by phosphorylationGO:00230142970.021
cellular protein complex assemblyGO:00436231880.021
neuron developmentGO:00486661130.021
Mouse
regulation of ras gtpase activityGO:00323181280.021
positive regulation of protein kinase activityGO:00458601900.021
histone modificationGO:00165702510.021
cell cycle phase transitionGO:00447701730.021
positive regulation of immune system processGO:00026842830.021
cation transmembrane transportGO:00986552380.021
regulation of cell cycle processGO:00105642660.020
regulation of secretionGO:00510461940.020
modification dependent macromolecule catabolic processGO:00436322120.020
regulation of cell adhesionGO:00301551660.020
response to organic cyclic compoundGO:00140702040.020
regulation of secretion by cellGO:19035301770.020
inorganic cation transmembrane transportGO:00986621940.020
regulation of proteolysisGO:00301622930.020
rhythmic behaviorGO:000762220.020
proteasomal protein catabolic processGO:00104981760.020
protein maturationGO:00516042330.020
blastoderm segmentationGO:000735020.020
circulatory system developmentGO:00723592620.020
hematopoietic or lymphoid organ developmentGO:00485341860.020
positive regulation of programmed cell deathGO:00430682490.020
mitotic cell cycle phase transitionGO:00447721620.020
cellular response to nitrogen compoundGO:19016991440.020
nitrogen compound transportGO:00717051910.019
ameboidal type cell migrationGO:00016671350.019
cell fate determinationGO:000170930.019
regulation of cytoskeleton organizationGO:00514931770.019
associative learningGO:000830610.019
microtubule based processGO:00070172100.019
cell activationGO:00017752130.019
hemopoiesisGO:00300971800.019
positive regulation of apoptotic processGO:00430652460.019
covalent chromatin modificationGO:00165692540.019
epithelial cell differentiationGO:00308551410.019
carbohydrate derivative biosynthetic processGO:19011372070.019
response to nitrogen compoundGO:19016981840.019
g protein coupled receptor signaling pathwayGO:00071862070.019
negative regulation of phosphorylationGO:00423261740.019
negative regulation of intracellular signal transductionGO:19025321830.019
adult locomotory behaviorGO:000834410.019
positive regulation of synaptic transmissionGO:005080640.019
chromatin organizationGO:00063253510.019
regulation of cell morphogenesisGO:00226041530.019
actin filament organizationGO:00070151280.019
negative regulation of hydrolase activityGO:00513461820.019
divalent inorganic cation transportGO:00725111580.018
muscle system processGO:0003012810.018
positive regulation of cellular component movementGO:00512721810.018
positive regulation of cell migrationGO:00303351720.018
positive regulation of cell differentiationGO:00455972110.018
post embryonic organ developmentGO:004856910.018
cell part morphogenesisGO:00329901370.018
Mouse
cell projection assemblyGO:00300311260.018
regulation of reactive oxygen species metabolic processGO:2000377410.018
regulation of vesicle mediated transportGO:00606271300.018
regulation of synaptic plasticityGO:004816730.018
cellular homeostasisGO:00197251960.018
regulation of establishment of protein localizationGO:00702012420.018
regulation of neurotransmitter secretionGO:004692830.018
protein targetingGO:00066051870.018
regulation of intracellular transportGO:00323861950.018
chromatin modificationGO:00165682980.018
central nervous system developmentGO:00074171230.018
regulation of response to external stimulusGO:00321012220.017
circadian behaviorGO:004851220.017
lipid biosynthetic processGO:00086101770.017
innate immune responseGO:00450871780.017
morphogenesis of embryonic epitheliumGO:001633140.017
cellular chemical homeostasisGO:00550821800.017
peripheral nervous system developmentGO:000742220.017
cellular response to dna damage stimulusGO:00069743790.017
glycoprotein metabolic processGO:00091001100.017
positive regulation of cell motilityGO:20001471770.017
cardiovascular system developmentGO:00723582620.017
head developmentGO:00603221080.017
rna processingGO:00063962550.017
endomembrane system organizationGO:00102561960.017
negative regulation of cell proliferationGO:00082852280.017
negative regulation of locomotionGO:00400131180.017
organophosphate biosynthetic processGO:00904071630.016
carbohydrate metabolic processGO:00059752070.016
anion transportGO:00068201610.016
angiogenesisGO:00015251470.016
taxisGO:00423301570.016
syncytium formation by plasma membrane fusionGO:000076820.016
modification dependent protein catabolic processGO:00199412090.016
rab protein signal transductionGO:003248240.016
microtubule cytoskeleton organizationGO:00002261760.016
cation homeostasisGO:00550801890.016
regulation of protein maturationGO:19033171500.016
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.016
regulation of wnt signaling pathwayGO:00301111230.016
peptidyl tyrosine modificationGO:00182121700.016
anterior posterior axis specificationGO:000994820.016
protein dephosphorylationGO:0006470810.016
negative regulation of cell migrationGO:00303361020.016
negative regulation of cell differentiationGO:00455961710.016
regulation of cell projection organizationGO:00313441070.016
negative regulation of transportGO:00510511760.016
single organism carbohydrate metabolic processGO:00447231930.016
response to external biotic stimulusGO:00432072610.016
organ morphogenesisGO:00098871470.016
positive regulation of reactive oxygen species biosynthetic processGO:190342820.016
neuron differentiationGO:00301821380.016
Mouse
glycoprotein biosynthetic processGO:0009101910.015
response to biotic stimulusGO:00096072760.015
neuroblast proliferationGO:000740540.015
endocytosisGO:00068971590.015
cell substrate adhesionGO:00315891320.015
protein localization to membraneGO:00726571600.015
apoptotic signaling pathwayGO:00971902680.015
spermatid differentiationGO:004851540.015
positive regulation of cellular component biogenesisGO:00440891580.015
response to organonitrogen compoundGO:00102431560.015
negative regulation of cell motilityGO:20001461040.015
leukocyte activationGO:00453211640.015
negative regulation of protein maturationGO:19033181420.015
spermatid developmentGO:000728640.015
negative regulation of cell cycleGO:00457861930.015
regulation of protein processingGO:00706131500.015
regulation of peptidase activityGO:00525471800.015
cell divisionGO:00513011680.015
cell growthGO:00160491600.015
positive regulation of secretion by cellGO:19035321080.015
embryo developmentGO:00097901230.015
positive regulation of cytokine productionGO:00018191670.015
divalent metal ion transportGO:00708381520.015
regulation of cell developmentGO:00602841610.014
Mouse
morphogenesis of a polarized epitheliumGO:000173830.014
regulation of immune responseGO:00507762010.014
monocarboxylic acid metabolic processGO:00327871850.014
positive regulation of protein serine threonine kinase activityGO:00719021190.014
response to lipidGO:00339932060.014
neurotransmitter secretionGO:000726940.014
regulation of cytoplasmic transportGO:19036491490.014
forebrain generation of neuronsGO:002187230.014
regulation of sequence specific dna binding transcription factor activityGO:00510902110.014
cell cell signalingGO:00072671550.014
negative regulation of protein phosphorylationGO:00019331400.014
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.014
blood vessel morphogenesisGO:00485141620.014
regulation of protein catabolic processGO:00421761550.014
ubiquitin dependent protein catabolic processGO:00065112060.014
inner ear morphogenesisGO:004247240.014
neuron projection regenerationGO:003110210.014
negative regulation of cell cycle processGO:00109481210.014
cardiac muscle cell contractionGO:008600340.014
calcium ion transportGO:00068161470.014
tissue morphogenesisGO:0048729960.014
embryonic epithelial tube formationGO:000183840.014
cranial nerve developmentGO:002154540.014
visual behaviorGO:000763220.014
negative regulation of cellular component movementGO:00512711060.014
cerebellum developmentGO:002154920.014
carboxylic acid biosynthetic processGO:0046394970.014
regulation of homeostatic processGO:00328441210.014
establishment of protein localization to organelleGO:00725941720.014
ribonucleoside monophosphate metabolic processGO:00091611870.014
primary neural tube formationGO:001402030.014
regulation of i kappab kinase nf kappab signalingGO:00431221620.014
positive regulation of protein transportGO:00512221350.014
epithelium migrationGO:00901321190.013
epithelial cell migrationGO:00106311190.013
limbic system developmentGO:002176130.013
myoblast fusionGO:000752010.013
convergent extensionGO:006002610.013
i kappab kinase nf kappab signalingGO:00072491660.013
response to cytokineGO:00340972320.013
immune effector processGO:00022521590.013
tissue migrationGO:00901301190.013
tube developmentGO:00352951250.013
single organismal cell cell adhesionGO:00163371480.013
negative regulation of proteolysisGO:00458611320.013
tube morphogenesisGO:0035239950.013
purine nucleoside monophosphate metabolic processGO:00091261860.013
positive regulation of reactive oxygen species metabolic processGO:2000379240.013
neural tube formationGO:000184130.013
metencephalon developmentGO:002203720.013
regulation of mitotic cell cycleGO:00073461890.013
regulation of epithelial cell migrationGO:0010632930.013
blood vessel developmentGO:00015681720.013
sensory perceptionGO:00076001030.013
regulation of endopeptidase activityGO:00525481700.013
matingGO:000761810.013
spinal cord developmentGO:002151040.013
divalent inorganic cation homeostasisGO:00725071360.013
photoreceptor cell differentiationGO:004653020.013
anterior posterior axis specification embryoGO:000859520.013
cellular response to organonitrogen compoundGO:00714171240.013
organelle fissionGO:00482851490.013
vasculature developmentGO:00019441810.013
nuclear transportGO:00511691790.013
negative regulation of organelle organizationGO:00106391260.013
response to woundingGO:00096111680.013
calcium ion transmembrane transportGO:0070588760.013
nucleoside monophosphate metabolic processGO:00091231910.013
lipid localizationGO:00108761060.013
mrna metabolic processGO:00160711750.012
purine ribonucleoside monophosphate metabolic processGO:00091671860.012
myeloid cell differentiationGO:00300991170.012
regulation of cell growthGO:00015581350.012
small molecule catabolic processGO:0044282920.012
muscle contractionGO:0006936730.012
organ formationGO:004864530.012
peptidyl lysine modificationGO:00182051440.012
organic acid biosynthetic processGO:0016053970.012
regulation of neural precursor cell proliferationGO:200017740.012
regulation of cell cycle phase transitionGO:19019871260.012
cellular ion homeostasisGO:00068731680.012
protein autophosphorylationGO:00467771230.012
muscle cell fate commitmentGO:004269340.012
organelle assemblyGO:00709251760.012
establishment of planar polarityGO:000173630.012
negative regulation of catabolic processGO:00098951040.012
oxidation reduction processGO:00551143960.012
brain developmentGO:0007420970.012
cellular response to organic cyclic compoundGO:00714071270.012
visual learningGO:000854210.012
t cell differentiation in thymusGO:003307740.012
cellular metal ion homeostasisGO:00068751460.012
regulation of protein complex assemblyGO:00432541470.012
cellular cation homeostasisGO:00300031630.012
regulation of protein modification by small protein conjugation or removalGO:19033201070.012
response to hypoxiaGO:0001666960.012
regulation of intracellular protein transportGO:00331571230.012
peptidyl tyrosine phosphorylationGO:00181081700.012
regulation of cell morphogenesis involved in differentiationGO:0010769830.012
lymphocyte activationGO:00466491330.012
response to hormoneGO:00097251750.012
nucleocytoplasmic transportGO:00069131760.012
response to oxidative stressGO:00069791210.012
tripartite regional subdivisionGO:000735120.012
negative regulation of transferase activityGO:00513481240.012
rna interferenceGO:001624640.012
sensory perception of painGO:001923340.012
response to axon injuryGO:004867810.012
somatic stem cell divisionGO:004810310.012
neural tube closureGO:000184330.012
regulation of meiotic cell cycleGO:005144540.012
cellular response to glucocorticoid stimulusGO:007138540.012
tube closureGO:006060630.012
neural crest cell developmentGO:001403230.012
regulation of dephosphorylationGO:0035303960.012
cellular calcium ion homeostasisGO:00068741170.012
protein oligomerizationGO:00512591730.012
positive regulation of organelle organizationGO:00106381950.012
establishment of protein localization to membraneGO:00901501210.012
actin mediated cell contractionGO:0070252120.012
negative regulation of synaptic transmissionGO:005080520.012
regulation of dna metabolic processGO:00510521530.012
positive regulation of secretionGO:00510471160.012
stem cell divisionGO:001714520.011
regulation of vasculature developmentGO:1901342970.011
axon regenerationGO:003110310.011
regulation of actin filament based processGO:00329701410.011
protein acylationGO:00435431380.011
response to inorganic substanceGO:00100351270.011
regulation of neurogenesisGO:0050767820.011
Mouse
erk1 and erk2 cascadeGO:00703711040.011
reproductive processGO:00224141060.011
negative regulation of protein processingGO:00109551420.011
regulation of mitotic cell cycle phase transitionGO:19019901180.011
lung alveolus developmentGO:004828640.011
epidermis morphogenesisGO:004873030.011
tissue regenerationGO:004224630.011
forebrain neuron differentiationGO:002187930.011
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.011
axis elongationGO:000340140.011
response to decreased oxygen levelsGO:0036293960.011
golgi vesicle transportGO:0048193800.011
negative regulation of protein kinase activityGO:0006469980.011
glycerolipid metabolic processGO:00464861070.011
peptidyl lysine acetylationGO:00183941010.011
atp metabolic processGO:00460341760.011
negative regulation of growthGO:0045926970.011
establishment of tissue polarityGO:000716430.011
cell migration involved in gastrulationGO:004207410.011
regulation of map kinase activityGO:00434051080.011
regulation of cell divisionGO:00513021160.011
protein localization to nucleusGO:00345041360.011
canonical wnt signaling pathwayGO:00600701160.011
metal ion homeostasisGO:00550651690.011
response to oxygen levelsGO:00704821000.011

ZSWIM6 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.024
disease of metabolismDOID:00146672950.023
sensory system diseaseDOID:00501552030.023
nervous system diseaseDOID:8634310.023
cancerDOID:1621670.020
organ system cancerDOID:00506861640.020
inherited metabolic disorderDOID:6552420.017
musculoskeletal system diseaseDOID:172230.016
eye and adnexa diseaseDOID:14921500.016
eye diseaseDOID:56141490.016
central nervous system diseaseDOID:3311860.016
connective tissue diseaseDOID:651090.014
bone diseaseDOID:0080001880.013
retinal diseaseDOID:56791180.013
neurodegenerative diseaseDOID:12891020.013
cardiovascular system diseaseDOID:12871060.013
immune system diseaseDOID:29141550.012