Homo sapiens

42 known processes

IFIH1

interferon induced with helicase C domain 1

(Aliases: MDA5,MGC133047,Hlcd,IDDM19,MDA-5)

IFIH1 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to other organismGO:00517072610.969
Human Mouse
defense response to virusGO:0051607710.962
Human
multi organism cellular processGO:00447641560.960
Human
innate immune responseGO:00450871780.945
Human Mouse
immune responseGO:00069553070.936
Human Mouse
response to biotic stimulusGO:00096072760.923
Human Mouse
defense responseGO:00069523150.921
Human Mouse
negative regulation of viral processGO:0048525660.913
negative regulation of viral genome replicationGO:0045071350.885
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.874
response to cytokineGO:00340972320.872
viral life cycleGO:00190581320.864
viral genome replicationGO:0019079500.846
regulation of multi organism processGO:00439001570.846
Human
positive regulation of interferon beta productionGO:0032728170.839
symbiosis encompassing mutualism through parasitismGO:00444031560.823
defense response to other organismGO:00985421290.788
Human
regulation of viral processGO:00507921030.788
pattern recognition receptor signaling pathwayGO:0002221480.779
Human
response to external biotic stimulusGO:00432072610.761
Human Mouse
response to virusGO:00096151260.725
Human Mouse
regulation of defense responseGO:00313471540.714
Human
positive regulation of rig i signaling pathwayGO:190024640.709
positive regulation of cytokine productionGO:00018191670.704
positive regulation of defense responseGO:0031349870.699
Human
immune response activating signal transductionGO:0002757900.697
Human
activation of innate immune responseGO:0002218550.688
Human
viral processGO:00160321460.670
cytokine productionGO:00018162470.661
regulation of defense response to virusGO:0050688330.660
Human
interspecies interaction between organismsGO:00444191560.647
immune effector processGO:00022521590.628
Human
regulation of viral genome replicationGO:0045069480.621
innate immune response activating signal transductionGO:0002758480.594
Human
regulation of intracellular transportGO:00323861950.541
Human
intracellular receptor signaling pathwayGO:00305221040.445
Human
regulation of immune effector processGO:0002697910.423
Human
cytoplasmic pattern recognition receptor signaling pathway in response to virusGO:003952880.420
Human
regulation of protein localization to nucleusGO:1900180850.411
Human
positive regulation of immune system processGO:00026842830.369
Human
regulation of innate immune responseGO:0045088970.368
Human
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.361
regulation of immune responseGO:00507762010.322
Human
regulation of response to biotic stimulusGO:0002831550.321
Human
activation of immune responseGO:00022531140.310
Human
regulation of cytokine productionGO:00018172320.307
regulation of mda 5 signaling pathwayGO:003953340.253
Human
regulation of establishment of protein localizationGO:00702012420.251
Human
regulation of viral induced cytoplasmic pattern recognition receptor signaling pathwayGO:003953170.250
Human
glycosylationGO:0070085710.249
regulation of cytoplasmic transportGO:19036491490.216
Human
positive regulation of multi organism processGO:0043902560.200
positive regulation of interferon alpha productionGO:0032727110.198
negative regulation of multi organism processGO:0043901920.193
Human
protein import into nucleusGO:00066061040.183
Human
glycoprotein biosynthetic processGO:0009101910.176
protein maturationGO:00516042330.174
protein ubiquitinationGO:00165673140.173
rig i signaling pathwayGO:003952970.170
Human
regulation of protein transportGO:00512232130.166
Human
regulation of nucleocytoplasmic transportGO:0046822980.165
Human
nuclear transportGO:00511691790.157
Human
regulation of protein import into nucleusGO:0042306780.152
Human
positive regulation of cell deathGO:00109422630.151
regulation of protein localizationGO:00328802960.143
Human
regulation of intracellular protein transportGO:00331571230.139
Human
negative regulation of transportGO:00510511760.137
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.134
positive regulation of innate immune responseGO:0045089790.132
Human
negative regulation of rig i signaling pathwayGO:003953620.131
Human
nucleocytoplasmic transportGO:00069131760.124
Human
positive regulation of type i interferon productionGO:0032481200.124
regulation of i kappab kinase nf kappab signalingGO:00431221620.121
response to interferon gammaGO:0034341390.117
intracellular protein transportGO:00068862700.116
Human
carbohydrate derivative biosynthetic processGO:19011372070.113
regulation of sequence specific dna binding transcription factor activityGO:00510902110.113
protein targetingGO:00066051870.112
Human
immune response regulating signaling pathwayGO:0002764970.103
Human
regulation of apoptotic signaling pathwayGO:20012331750.103
negative regulation of catalytic activityGO:00430863350.101
chemical homeostasisGO:00488783060.098
glycoprotein metabolic processGO:00091001100.095
nuclear importGO:00511701060.094
Human
mda 5 signaling pathwayGO:003953040.094
Human
cellular response to cytokine stimulusGO:00713451810.092
negative regulation of protein metabolic processGO:00512483910.092
protein modification by small protein conjugationGO:00324463420.090
positive regulation of response to external stimulusGO:0032103880.085
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.082
organonitrogen compound biosynthetic processGO:19015662000.081
protein localization to nucleusGO:00345041360.081
Human
establishment of protein localization to organelleGO:00725941720.081
Human
cellular response to lipopolysaccharideGO:0071222570.079
regulation of response to external stimulusGO:00321012220.078
Human
negative regulation of cellular protein metabolic processGO:00322693530.077
positive regulation of immune effector processGO:0002699400.077
negative regulation of nf kappab transcription factor activityGO:0032088510.075
regulation of peptidase activityGO:00525471800.071
negative regulation of sequence specific dna binding transcription factor activityGO:0043433890.070
macromolecule glycosylationGO:0043413630.068
i kappab kinase nf kappab signalingGO:00072491660.067
response to dsrnaGO:0043331250.066
Human
cellular response to nitrogen compoundGO:19016991440.065
Human
response to nitrogen compoundGO:19016981840.065
Human
rna interferenceGO:001624640.064
Human
positive regulation of catabolic processGO:00098963100.063
cellular response to dna damage stimulusGO:00069743790.063
protein targeting to nucleusGO:00447441040.061
Human
single organism carbohydrate metabolic processGO:00447231930.059
protein polyubiquitinationGO:00002091100.059
protein oligomerizationGO:00512591730.059
negative regulation of multicellular organismal processGO:00512413170.058
Human
positive regulation of transportGO:00510503360.057
Human
apoptotic signaling pathwayGO:00971902680.056
positive regulation of programmed cell deathGO:00430682490.055
positive regulation of protein import into nucleusGO:0042307460.055
Human
detection of muramyl dipeptideGO:003249810.055
cytoplasmic transportGO:00164823790.053
Human
positive regulation of immune responseGO:00507781590.053
Human
positive regulation of hydrolase activityGO:00513453310.053
negative regulation of intracellular transportGO:0032387600.052
positive regulation of intracellular protein transportGO:0090316760.052
Human
single organism cellular localizationGO:19025803320.052
Human
regulation of protein modification by small protein conjugation or removalGO:19033201070.049
regulation of tumor necrosis factor productionGO:0032680430.048
positive regulation of phosphorylationGO:00423273940.047
cellular response to oxygen containing compoundGO:19017012760.047
lipoprotein biosynthetic processGO:0042158330.046
response to oxygen containing compoundGO:19017003690.046
positive regulation of intracellular transportGO:00323881040.046
Human
organophosphate biosynthetic processGO:00904071630.046
purine nucleoside catabolic processGO:00061523980.046
nucleoside triphosphate metabolic processGO:00091414220.045
regulation of ribonuclease activityGO:006070030.044
cellular response to dsrnaGO:0071359190.044
Human
negative regulation of immune system processGO:00026831360.044
Human
negative regulation of protein maturationGO:19033181420.044
cellular macromolecule catabolic processGO:00442653800.043
chromatin organizationGO:00063253510.042
negative regulation of peptidase activityGO:0010466910.042
negative regulation of programmed cell deathGO:00430693210.041
transmembrane transportGO:00550853990.040
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.040
positive regulation of protein transportGO:00512221350.040
Human
regulation of protein targetingGO:1903533910.040
Human
negative regulation of hydrolase activityGO:00513461820.040
negative regulation of intracellular signal transductionGO:19025321830.040
Human
ion transmembrane transportGO:00342203380.039
response to molecule of bacterial originGO:0002237820.039
regulation of protein processingGO:00706131500.038
wnt signaling pathwayGO:00160551560.038
regulation of protein maturationGO:19033171500.038
cytoplasmic pattern recognition receptor signaling pathwayGO:0002753120.038
Human
cellular response to interferon alphaGO:003545740.038
regulation of transcription factor import into nucleusGO:0042990390.037
Human
mapk cascadeGO:00001652880.037
protein glycosylationGO:0006486620.037
blood vessel developmentGO:00015681720.037
negative regulation of protein transportGO:0051224750.036
modification dependent macromolecule catabolic processGO:00436322120.036
circulatory system developmentGO:00723592620.036
regulation of angiogenesisGO:0045765920.036
regulation of proteolysisGO:00301622930.036
negative regulation of apoptotic processGO:00430663160.036
inorganic anion transmembrane transportGO:0098661470.035
negative regulation of protein localization to nucleusGO:1900181340.035
regulation of cell migrationGO:00303342890.035
Human
defense response to bacteriumGO:0042742630.034
positive regulation of apoptotic processGO:00430652460.033
carbohydrate metabolic processGO:00059752070.033
double strand break repairGO:00063021010.033
posttranscriptional regulation of gene expressionGO:00106082130.033
Human
response to lipidGO:00339932060.033
response to exogenous dsrnaGO:0043330100.032
purine containing compound catabolic processGO:00725234110.032
cellular response to type i interferonGO:0071357120.032
multicellular organismal agingGO:001025930.032
positive regulation of nucleocytoplasmic transportGO:0046824540.032
Human
positive regulation of mapk cascadeGO:00434101900.032
regulation of anatomical structure morphogenesisGO:00226032860.031
negative regulation of phosphate metabolic processGO:00459362670.031
purine ribonucleotide catabolic processGO:00091544040.030
purine nucleoside triphosphate metabolic processGO:00091444120.030
positive regulation of tumor necrosis factor superfamily cytokine productionGO:1903557220.030
negative regulation of cell proliferationGO:00082852280.030
purine nucleotide biosynthetic processGO:0006164840.030
cellular response to virusGO:009858690.029
Human
extrinsic apoptotic signaling pathwayGO:00971911190.029
protein localization to organelleGO:00333652800.029
Human
ribonucleoside triphosphate catabolic processGO:00092033910.028
purine ribonucleoside triphosphate catabolic processGO:00092073910.028
negative regulation of proteolysisGO:00458611320.028
nucleotide biosynthetic processGO:00091651090.028
purine nucleoside triphosphate catabolic processGO:00091463920.028
regulation of locomotionGO:00400123290.028
Human
cellular response to lipidGO:00713961270.028
regulation of rig i signaling pathwayGO:003953560.028
Human
negative regulation of nucleocytoplasmic transportGO:0046823370.027
negative regulation of defense response to virusGO:0050687100.027
Human
regulation of cysteine type endopeptidase activityGO:20001161270.027
regulation of purine nucleotide metabolic processGO:19005422640.027
nucleoside catabolic processGO:00091644080.027
cellular amino acid metabolic processGO:00065201160.027
negative regulation of defense response to virus by hostGO:005068940.026
negative regulation of protein processingGO:00109551420.026
multi organism localizationGO:1902579140.026
lipoprotein metabolic processGO:0042157420.026
chromatin assemblyGO:0031497610.026
negative regulation of intracellular protein transportGO:0090317420.025
vesicle mediated transportGO:00161923710.025
interferon beta productionGO:0032608230.025
purine ribonucleoside catabolic processGO:00461303980.025
ribonucleotide catabolic processGO:00092614050.025
regulation of interferon alpha productionGO:0032647110.024
negative regulation of cytokine productionGO:0001818820.024
Human
regulation of transferase activityGO:00513383550.024
nucleotide catabolic processGO:00091664080.024
cellular response to biotic stimulusGO:0071216710.024
blood vessel morphogenesisGO:00485141620.024
covalent chromatin modificationGO:00165692540.024
negative regulation of protein ubiquitinationGO:0031397350.024
purine containing compound biosynthetic processGO:0072522880.024
purine ribonucleoside triphosphate metabolic processGO:00092054110.024
regulation of bindingGO:00510981110.024
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.024
vasculature developmentGO:00019441810.024
chromatin assembly or disassemblyGO:0006333780.024
positive regulation of myeloid cell differentiationGO:0045639390.023
multi organism intracellular transportGO:1902583140.023
mrna metabolic processGO:00160711750.023
regulation of protein ubiquitinationGO:0031396950.023
release of cytoplasmic sequestered nf kappabGO:000858840.023
positive regulation of protein phosphorylationGO:00019343130.023
negative regulation of phosphorus metabolic processGO:00105632670.023
positive regulation of proteolysisGO:00458621420.022
purine ribonucleoside metabolic processGO:00461284370.022
negative regulation of cytoplasmic transportGO:1903650460.022
organophosphate catabolic processGO:00464344300.022
positive regulation of cellular catabolic processGO:00313312840.022
leukocyte activationGO:00453211640.022
negative regulation of response to external stimulusGO:0032102830.021
Human
cell fate determinationGO:000170930.021
ribonucleoside catabolic processGO:00424544060.021
regulation of cellular component movementGO:00512703340.021
Human
response to lipopolysaccharideGO:0032496700.021
negative regulation of protein import into nucleus translocationGO:003315930.021
hemopoiesisGO:00300971800.021
regulation of dna metabolic processGO:00510521530.021
protein importGO:00170381300.021
Human
signal transduction by phosphorylationGO:00230142970.021
regulation of chromosome organizationGO:00330441030.020
negative regulation of cell deathGO:00605483450.020
peptide transportGO:0015833740.020
nucleoside phosphate biosynthetic processGO:19012931090.020
amide transportGO:0042886760.020
regulation of cell motilityGO:20001452990.020
Human
modification dependent protein catabolic processGO:00199412090.020
regulation of cellular response to stressGO:00801352440.020
response to bacteriumGO:00096171440.020
glycosyl compound catabolic processGO:19016584130.020
protein deubiquitinationGO:0016579790.020
regulation of kinase activityGO:00435493140.019
monosaccharide metabolic processGO:0005996740.019
proteolysis involved in cellular protein catabolic processGO:00516032440.019
positive regulation of nf kappab transcription factor activityGO:0051092810.019
purine nucleotide catabolic processGO:00061954050.019
regulation of cell differentiationGO:00455953930.018
regulation of interferon beta productionGO:0032648220.018
protein k63 linked ubiquitinationGO:0070534310.018
positive regulation of cytoplasmic transportGO:1903651820.018
Human
response to abiotic stimulusGO:00096283360.018
dna repairGO:00062811980.018
angiogenesisGO:00015251470.018
secretionGO:00469032540.018
regulation of nucleotide metabolic processGO:00061402690.018
guanosine containing compound catabolic processGO:19010692390.017
negative regulation of endopeptidase activityGO:0010951840.017
melanin metabolic processGO:000658210.017
determination of adult lifespanGO:000834020.017
nucleoside phosphate catabolic processGO:19012924120.017
multi organism transportGO:0044766140.017
cellular response to organic cyclic compoundGO:00714071270.017
Human
divalent inorganic cation transportGO:00725111580.017
ribonucleoside monophosphate metabolic processGO:00091611870.017
secretion by cellGO:00329402260.017
transcription factor import into nucleusGO:0042991400.017
Human
myoblast fusionGO:000752010.016
ribonucleoside triphosphate metabolic processGO:00091994120.016
response to organic cyclic compoundGO:00140702040.016
Human
negative regulation of protein import into nucleusGO:0042308300.016
stress activated protein kinase signaling cascadeGO:0031098940.016
single organism nuclear importGO:19025931040.016
Human
dna conformation changeGO:00711031130.016
cardiovascular system developmentGO:00723582620.016
response to tumor necrosis factorGO:0034612760.016
positive regulation of transcription factor import into nucleusGO:0042993250.016
Human
intracellular transport of viral protein in host cellGO:001906040.016
small gtpase mediated signal transductionGO:0007264780.016
tumor necrosis factor superfamily cytokine productionGO:0071706450.016
cellular response to interferon gammaGO:0071346240.016
regulation of defense response to virus by hostGO:0050691220.016
Human
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555440.016
negative regulation of phosphorylationGO:00423261740.015
cellular response to molecule of bacterial originGO:0071219620.015
cellular macromolecular complex assemblyGO:00346223240.015
Human
mitochondrion organizationGO:00070051560.015
stress activated mapk cascadeGO:0051403930.015
regulation of mapk cascadeGO:00434082620.015
nucleoside monophosphate catabolic processGO:00091251590.015
negative regulation of cell cycleGO:00457861930.015
protein processingGO:00164852260.015
positive regulation of purine nucleotide metabolic processGO:19005442270.015
metal ion transportGO:00300012720.015
positive regulation of response to biotic stimulusGO:0002833180.015
cation transportGO:00068123310.015
biological adhesionGO:00226103310.015
alditol phosphate metabolic processGO:005264630.014
t helper 2 cell cytokine productionGO:003574530.014
fibroblast proliferationGO:0048144330.014
positive regulation of protein complex assemblyGO:0031334860.014
regulation of cellular component biogenesisGO:00440872810.014
nucleoside monophosphate metabolic processGO:00091231910.014
single organism membrane organizationGO:00448022680.014
calcium ion transportGO:00068161470.014
response to type i interferonGO:0034340140.014
mitotic cell cycleGO:00002783260.014
mitotic cell cycle processGO:19030472860.014
immune system developmentGO:00025201950.014
regulation of syncytium formation by plasma membrane fusionGO:006014220.014
nucleic acid phosphodiester bond hydrolysisGO:00903051020.014
Human
release of cytochrome c from mitochondriaGO:0001836350.014
regulation of secretion by cellGO:19035301770.014
protein auto adp ribosylationGO:007021340.014
protein secretionGO:0009306980.014
maintenance of locationGO:00512351120.014
regulation of gene expression epigeneticGO:0040029730.014
Human
atp metabolic processGO:00460341760.014
cd4 positive alpha beta t cell differentiationGO:004336740.013
regulation of ion transportGO:00432691890.013
regulation of cytoskeleton organizationGO:00514931770.013
cd4 positive alpha beta t cell cytokine productionGO:003574340.013
positive regulation of endopeptidase activityGO:0010950840.013
positive regulation of cellular component organizationGO:00511303760.013
membrane organizationGO:00610242920.013
ras protein signal transductionGO:0007265730.013
regulation of interferon alpha biosynthetic processGO:004535440.013
positive regulation of chemokine productionGO:0032722220.013
negative regulation of cellular component organizationGO:00511292350.013
negative regulation of protein modification processGO:00314002000.013
cellular response to muramyl dipeptideGO:007122530.013
regulation of cell cycleGO:00517263930.013
type i interferon productionGO:0032606270.013
positive regulation of cell differentiationGO:00455972110.013
protein modification by small protein removalGO:0070646920.013
regulation of vasculature developmentGO:1901342970.013
positive regulation of stress activated protein kinase signaling cascadeGO:0070304610.012
gene silencing by mirnaGO:0035195230.012
Human
anatomical structure homeostasisGO:00602491000.012
negative regulation of protein modification by small protein conjugation or removalGO:1903321410.012
nucleoside triphosphate catabolic processGO:00091433940.012
interaction with hostGO:0051701420.012
protein catabolic processGO:00301633250.012
anatomical structure formation involved in morphogenesisGO:00486462840.012
purine ribonucleoside monophosphate metabolic processGO:00091671860.012
negative regulation of mitotic cell cycleGO:00459301020.012
negative regulation of transferase activityGO:00513481240.012
protein autoubiquitinationGO:0051865370.012
positive regulation of tumor necrosis factor productionGO:0032760210.012
ribonucleoside monophosphate catabolic processGO:00091581580.012
jnk cascadeGO:0007254800.012
negative regulation of protein phosphorylationGO:00019331400.012
negative regulation of acute inflammatory responseGO:000267430.012
endosomal transportGO:00161971290.012
actin filament based processGO:00300292240.012
positive regulation of protein localization to nucleusGO:1900182480.012
Human
leukocyte differentiationGO:0002521980.012
positive regulation of stress activated mapk cascadeGO:0032874600.012
sequestering of metal ionGO:0051238240.012
syncytium formation by plasma membrane fusionGO:000076820.011
regulation of protein bindingGO:0043393660.011
rhythmic behaviorGO:000762220.011
response to radiationGO:00093141510.011
regulation of response to interferon gammaGO:006033070.011
tumor necrosis factor productionGO:0032640430.011
regulation of fibroblast proliferationGO:0048145320.011
regulation of interleukin 2 secretionGO:190004020.011
negative regulation of cell differentiationGO:00455961710.011
negative regulation of locomotionGO:00400131180.011
ion homeostasisGO:00508012300.011
regulation of interleukin 6 productionGO:0032675370.011
positive regulation of locomotionGO:00400171860.011
positive regulation of apoptotic signaling pathwayGO:2001235700.011
negative regulation of developmental processGO:00510932470.011
regulation of metal ion transportGO:00109591200.011
regulation of protein secretionGO:0050708860.011
regulation of cell cycle phase transitionGO:19019871260.011
positive regulation of peptidase activityGO:0010952880.011
apoptotic mitochondrial changesGO:0008637570.011
activation of cysteine type endopeptidase activityGO:0097202570.011
spermatid differentiationGO:004851540.011
positive regulation of nucleoside metabolic processGO:00459791860.011
ubiquitin dependent protein catabolic processGO:00065112060.011
regulation of stress activated protein kinase signaling cascadeGO:0070302850.011
regulation of type i interferon productionGO:0032479260.010
regulation of ion transmembrane transportGO:00347651320.010
endocytosisGO:00068971590.010
cytokine mediated signaling pathwayGO:00192211090.010
rna phosphodiester bond hydrolysisGO:0090501350.010
Human
positive regulation of nucleotide catabolic processGO:00308131850.010
spermatid developmentGO:000728640.010

IFIH1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.010
acquired metabolic diseaseDOID:0060158580.010
aicardi goutieres syndromeDOID:005062970.001