Homo sapiens

122 known processes

CYTH3

cytohesin 3

(Aliases: PSCD3,GRP1,ARNO3)

CYTH3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
ras protein signal transductionGO:0007265730.128
small gtpase mediated signal transductionGO:0007264780.122
rho protein signal transductionGO:0007266260.100
cellular amino acid metabolic processGO:00065201160.081
amine metabolic processGO:0009308440.071
post embryonic developmentGO:000979120.071
Fly
cellular ketone metabolic processGO:0042180800.071
purine ribonucleotide catabolic processGO:00091544040.070
positive regulation of phosphorylationGO:00423273940.069
Fly
mapk cascadeGO:00001652880.069
Fly
purine ribonucleoside metabolic processGO:00461284370.067
cellular amine metabolic processGO:0044106410.065
purine containing compound catabolic processGO:00725234110.063
nucleoside catabolic processGO:00091644080.061
regulation of cellular ketone metabolic processGO:0010565500.061
actin filament based processGO:00300292240.060
organophosphate catabolic processGO:00464344300.059
nucleoside triphosphate metabolic processGO:00091414220.059
ribonucleoside triphosphate catabolic processGO:00092033910.057
regulation of cell differentiationGO:00455953930.057
signal transduction by phosphorylationGO:00230142970.056
Fly
nervous system developmentGO:00073992930.055
purine ribonucleoside catabolic processGO:00461303980.054
ribonucleoside triphosphate metabolic processGO:00091994120.054
vesicle mediated transportGO:00161923710.054
purine nucleotide catabolic processGO:00061954050.053
regulation of ras protein signal transductionGO:00465781550.053
ribonucleoside catabolic processGO:00424544060.053
purine nucleoside triphosphate metabolic processGO:00091444120.052
purine nucleoside catabolic processGO:00061523980.052
regulation of cellular amine metabolic processGO:0033238110.051
regulation of cellular amino acid metabolic processGO:000652160.051
purine nucleoside triphosphate catabolic processGO:00091463920.051
multicellular organismal agingGO:001025930.050
regulation of mapk cascadeGO:00434082620.050
Fly
purine ribonucleoside triphosphate catabolic processGO:00092073910.049
positive regulation of cellular amino acid metabolic processGO:004576430.049
nucleotide catabolic processGO:00091664080.049
determination of adult lifespanGO:000834020.049
positive regulation of cellular amine metabolic processGO:003324070.049
nucleoside phosphate catabolic processGO:19012924120.048
response to oxygen containing compoundGO:19017003690.048
purine ribonucleoside triphosphate metabolic processGO:00092054110.047
positive regulation of catabolic processGO:00098963100.046
ribonucleotide catabolic processGO:00092614050.045
cell morphogenesisGO:00009022960.043
regulation of purine nucleotide metabolic processGO:19005422640.042
nucleoside triphosphate catabolic processGO:00091433940.042
negative regulation of cellular protein metabolic processGO:00322693530.042
positive regulation of hydrolase activityGO:00513453310.041
cell adhesionGO:00071553250.041
Human Mouse
regulation of cell cycleGO:00517263930.041
female gamete generationGO:000729220.040
regulation of transferase activityGO:00513383550.040
Fly
gtp catabolic processGO:00061842370.040
transmembrane transportGO:00550853990.040
actin cytoskeleton organizationGO:00300362070.040
regulation of cellular component biogenesisGO:00440872810.039
gtp metabolic processGO:00460392390.039
negative regulation of protein metabolic processGO:00512483910.039
cytoplasmic transportGO:00164823790.039
regulation of small gtpase mediated signal transductionGO:00510561560.038
positive regulation of protein phosphorylationGO:00019343130.038
Fly
regulation of anatomical structure morphogenesisGO:00226032860.038
segmentationGO:003528240.038
cellular response to endogenous stimulusGO:00714953360.037
lipid metabolic processGO:00066293810.037
regulation of nucleotide metabolic processGO:00061402690.037
regulation of protein kinase activityGO:00458592890.037
Fly
glycosyl compound catabolic processGO:19016584130.036
single organism cellular localizationGO:19025803320.036
locomotory behaviorGO:000762610.036
oogenesisGO:004847720.036
positive regulation of cellular catabolic processGO:00313312840.036
positive regulation of nucleotide metabolic processGO:00459812300.036
anatomical structure formation involved in morphogenesisGO:00486462840.036
cellular component morphogenesisGO:00329893140.035
positive regulation of nucleoside metabolic processGO:00459791860.034
positive regulation of developmental processGO:00510943140.034
Fly
membrane organizationGO:00610242920.034
neuromuscular junction developmentGO:000752830.034
negative regulation of catalytic activityGO:00430863350.033
cellular lipid metabolic processGO:00442553030.033
enzyme linked receptor protein signaling pathwayGO:00071673030.033
regulation of gtp catabolic processGO:00331241800.033
regulation of protein localizationGO:00328802960.033
regulation of nucleotide catabolic processGO:00308112050.033
cation transportGO:00068123310.033
mitotic cell cycleGO:00002783260.032
negative regulation of multicellular organismal processGO:00512413170.032
positive regulation of cellular component organizationGO:00511303760.032
positive regulation of purine nucleotide metabolic processGO:19005442270.032
system processGO:00030083490.032
guanosine containing compound catabolic processGO:19010692390.032
immune responseGO:00069553070.031
ion transmembrane transportGO:00342203380.031
cell developmentGO:00484683280.031
protein catabolic processGO:00301633250.031
regulation of kinase activityGO:00435493140.030
Fly
cellular macromolecular complex assemblyGO:00346223240.030
regulation of protein transportGO:00512232130.029
cellular response to oxygen containing compoundGO:19017012760.029
circulatory system developmentGO:00723592620.029
guanosine containing compound metabolic processGO:19010682440.029
regulation of cellular component movementGO:00512703340.029
regulation of purine nucleotide catabolic processGO:00331212050.029
intracellular protein transportGO:00068862700.028
inorganic ion transmembrane transportGO:00986602310.028
cardiovascular system developmentGO:00723582620.028
blastoderm segmentationGO:000735020.028
mitotic cell cycle processGO:19030472860.028
anterior posterior axis specificationGO:000994820.027
negative regulation of phosphate metabolic processGO:00459362670.027
cation transmembrane transportGO:00986552380.027
cell projection organizationGO:00300302520.027
positive regulation of transportGO:00510503360.027
response to abiotic stimulusGO:00096283360.027
biological adhesionGO:00226103310.027
Human Mouse
regulation of proteolysisGO:00301622930.027
regulation of gtpase activityGO:00430871800.027
positive regulation of cell differentiationGO:00455972110.027
protein maturationGO:00516042330.026
response to growth factorGO:00708482050.026
single organism membrane organizationGO:00448022680.026
carbohydrate metabolic processGO:00059752070.026
hindbrain developmentGO:003090230.026
chemical homeostasisGO:00488783060.026
regulation of actin filament based processGO:00329701410.026
positive regulation of gtpase activityGO:00435471660.026
regulation of cytoskeleton organizationGO:00514931770.026
Fly
negative regulation of intracellular signal transductionGO:19025321830.026
organ formationGO:004864530.026
negative regulation of developmental processGO:00510932470.026
positive regulation of nucleotide catabolic processGO:00308131850.025
negative regulation of phosphorus metabolic processGO:00105632670.025
regulation of establishment of protein localizationGO:00702012420.025
regulation of intracellular transportGO:00323861950.025
morphogenesis of embryonic epitheliumGO:001633140.024
positive regulation of protein kinase activityGO:00458601900.024
Fly
protein modification by small protein conjugationGO:00324463420.024
regenerationGO:003109940.024
regulation of cell developmentGO:00602841610.024
cellular macromolecule catabolic processGO:00442653800.024
protein localization to organelleGO:00333652800.024
negative regulation of cell deathGO:00605483450.024
embryonic epithelial tube formationGO:000183840.024
positive regulation of purine nucleotide catabolic processGO:00331231850.024
positive regulation of programmed cell deathGO:00430682490.024
dephosphorylationGO:00163112090.024
positive regulation of erk1 and erk2 cascadeGO:0070374750.024
negative regulation of cellular component organizationGO:00511292350.024
positive regulation of immune system processGO:00026842830.024
defense responseGO:00069523150.024
regulation of locomotionGO:00400123290.024
protein ubiquitinationGO:00165673140.023
single organism carbohydrate metabolic processGO:00447231930.023
secretion by cellGO:00329402260.023
positive regulation of cell deathGO:00109422630.023
positive regulation of transferase activityGO:00513472270.023
Fly
compound eye developmentGO:004874910.023
positive regulation of organelle organizationGO:00106381950.023
cellular response to growth factor stimulusGO:00713631970.023
cellular response to dna damage stimulusGO:00069743790.023
erk1 and erk2 cascadeGO:00703711040.023
protein processingGO:00164852260.023
endomembrane system organizationGO:00102561960.023
regulation of cell migrationGO:00303342890.023
inorganic cation transmembrane transportGO:00986621940.022
positive regulation of cell proliferationGO:00082843010.022
metal ion transportGO:00300012720.022
negative regulation of cellular amine metabolic processGO:003323930.022
regulation of cell cycle processGO:00105642660.022
positive regulation of apoptotic processGO:00430652460.022
morphogenesis of a polarized epitheliumGO:000173830.022
protein targetingGO:00066051870.022
regulation of mitotic cell cycleGO:00073461890.022
positive regulation of gtp catabolic processGO:00331261660.022
rhythmic behaviorGO:000762220.022
regulation of cell motilityGO:20001452990.022
oocyte differentiationGO:000999420.022
neurogenesisGO:00220081690.022
myoblast fusionGO:000752010.021
negative regulation of programmed cell deathGO:00430693210.021
peripheral nervous system developmentGO:000742220.021
oxidation reduction processGO:00551143960.021
neurotransmitter secretionGO:000726940.021
organonitrogen compound biosynthetic processGO:19015662000.021
circadian behaviorGO:004851220.021
cellular protein complex assemblyGO:00436231880.021
negative regulation of cellular amino acid metabolic processGO:004576320.021
negative regulation of phosphorylationGO:00423261740.021
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.021
negative regulation of protein modification processGO:00314002000.021
growthGO:00400072020.021
Fly
cellular protein catabolic processGO:00442572610.020
regulation of ras gtpase activityGO:00323181280.020
organophosphate biosynthetic processGO:00904071630.020
hematopoietic or lymphoid organ developmentGO:00485341860.020
ion homeostasisGO:00508012300.020
cell growthGO:00160491600.020
motor neuron axon guidanceGO:000804520.020
regulation of cell morphogenesisGO:00226041530.020
regulation of cytokine productionGO:00018172320.020
regulation of protein maturationGO:19033171500.020
regulation of nucleoside metabolic processGO:00091182090.020
nuclear transportGO:00511691790.020
maintenance of locationGO:00512351120.020
apoptotic signaling pathwayGO:00971902680.020
carbohydrate derivative biosynthetic processGO:19011372070.020
oocyte developmentGO:004859910.020
negative regulation of apoptotic processGO:00430663160.020
regulation of erk1 and erk2 cascadeGO:0070372990.020
positive regulation of mapk cascadeGO:00434101900.020
Fly
reactive oxygen species metabolic processGO:0072593750.020
tripartite regional subdivisionGO:000735120.020
syncytium formation by plasma membrane fusionGO:000076820.019
nitrogen compound transportGO:00717051910.019
negative regulation of cell proliferationGO:00082852280.019
regulation of cellular response to stressGO:00801352440.019
negative regulation of hydrolase activityGO:00513461820.019
spermatid differentiationGO:004851540.019
regulation of sequence specific dna binding transcription factor activityGO:00510902110.019
nucleocytoplasmic transportGO:00069131760.019
anterior posterior axis specification embryoGO:000859520.019
cell morphogenesis involved in differentiationGO:00009041440.019
neural tube formationGO:000184130.019
positive regulation of synaptic transmissionGO:005080640.019
wnt signaling pathwayGO:00160551560.019
adult locomotory behaviorGO:000834410.019
memoryGO:000761330.019
positive regulation of ras gtpase activityGO:00323201170.019
cytokine productionGO:00018162470.018
cell activationGO:00017752130.018
positive regulation of kinase activityGO:00336742040.018
Fly
response to cytokineGO:00340972320.018
regulation of protein catabolic processGO:00421761550.018
response to other organismGO:00517072610.018
innate immune responseGO:00450871780.018
cell part morphogenesisGO:00329901370.018
regulation of neurotransmitter secretionGO:004692830.018
negative regulation of cell differentiationGO:00455961710.018
response to external biotic stimulusGO:00432072610.018
response to biotic stimulusGO:00096072760.018
cell fate determinationGO:000170930.018
regulation of response to external stimulusGO:00321012220.018
neuron differentiationGO:00301821380.018
microtubule cytoskeleton organizationGO:00002261760.018
Fly
vasculature developmentGO:00019441810.017
negative regulation of cell cycleGO:00457861930.017
reactive oxygen species biosynthetic processGO:190340940.017
metencephalon developmentGO:002203720.017
stem cell divisionGO:001714520.017
primary neural tube formationGO:001402030.017
regulation of synaptic plasticityGO:004816730.017
nerve developmentGO:002167540.017
actin filament organizationGO:00070151280.017
positive regulation of cellular component biogenesisGO:00440891580.017
histone modificationGO:00165702510.017
single organism cell adhesionGO:00986021790.017
regulation of intracellular protein transportGO:00331571230.017
modification dependent macromolecule catabolic processGO:00436322120.017
regulation of immune responseGO:00507762010.017
regulation of growthGO:00400081650.017
Fly
monocarboxylic acid metabolic processGO:00327871850.017
epithelium developmentGO:00604292270.017
regulation of secretionGO:00510461940.017
spermatid developmentGO:000728640.017
immune system developmentGO:00025201950.017
regulation of cytoplasmic transportGO:19036491490.017
regulation of protein complex assemblyGO:00432541470.016
regulation of protein serine threonine kinase activityGO:00719001790.016
Fly
proteasomal protein catabolic processGO:00104981760.016
regulation of vesicle mediated transportGO:00606271300.016
Fly
hemopoiesisGO:00300971800.016
reactive nitrogen species metabolic processGO:200105730.016
regulation of secretion by cellGO:19035301770.016
salivary gland morphogenesisGO:000743540.016
cerebellum developmentGO:002154920.016
establishment of planar polarityGO:000173630.016
chromatin organizationGO:00063253510.016
proteolysis involved in cellular protein catabolic processGO:00516032440.016
establishment of protein localization to organelleGO:00725941720.016
posttranscriptional regulation of gene expressionGO:00106082130.016
endocytosisGO:00068971590.016
Fly
negative regulation of protein maturationGO:19033181420.016
cellular homeostasisGO:00197251960.016
epithelial cell differentiationGO:00308551410.016
organelle assemblyGO:00709251760.016
modification dependent protein catabolic processGO:00199412090.016
ubiquitin dependent protein catabolic processGO:00065112060.016
associative learningGO:000830610.016
ribonucleoside monophosphate metabolic processGO:00091611870.016
secretionGO:00469032540.016
forelimb morphogenesisGO:003513640.016
regulation of reactive oxygen species biosynthetic processGO:190342630.016
taxisGO:00423301570.016
endosomal transportGO:00161971290.016
cell type specific apoptotic processGO:00972851250.015
regulation of protein processingGO:00706131500.015
inner ear morphogenesisGO:004247240.015
protein oligomerizationGO:00512591730.015
microtubule based processGO:00070172100.015
Fly
anion transportGO:00068201610.015
protein autophosphorylationGO:00467771230.015
release of cytoplasmic sequestered nf kappabGO:000858840.015
negative regulation of locomotionGO:00400131180.015
ossificationGO:00015031210.015
regulation of wnt signaling pathwayGO:00301111230.015
neuroblast proliferationGO:000740540.015
spinal cord developmentGO:002151040.015
purine nucleoside monophosphate metabolic processGO:00091261860.015
cardiac muscle cell contractionGO:008600340.015
response to nitrogen compoundGO:19016981840.015
nucleoside monophosphate metabolic processGO:00091231910.015
establishment or maintenance of bipolar cell polarityGO:006124520.015
neuron developmentGO:00486661130.015
response to axon injuryGO:004867810.015
negative regulation of protein phosphorylationGO:00019331400.015
heart formationGO:006091420.015
regulation of dna metabolic processGO:00510521530.015
organic hydroxy compound metabolic processGO:19016151470.015
cation homeostasisGO:00550801890.015
plasma membrane organizationGO:00070091150.015
protein localization to membraneGO:00726571600.015
regulation of neural precursor cell proliferationGO:200017740.015
positive regulation of cell migrationGO:00303351720.015
establishment of tissue polarityGO:000716430.015
response to organic cyclic compoundGO:00140702040.014
peptidyl tyrosine modificationGO:00182121700.014
cellular cation homeostasisGO:00300031630.014
cell cycle phase transitionGO:00447701730.014
ameboidal type cell migrationGO:00016671350.014
cell projection assemblyGO:00300311260.014
tube closureGO:006060630.014
blood vessel developmentGO:00015681720.014
purine ribonucleoside monophosphate metabolic processGO:00091671860.014
cell divisionGO:00513011680.014
developmental programmed cell deathGO:001062330.014
establishment of protein localization to membraneGO:00901501210.014
regulation of ion transportGO:00432691890.014
cell projection morphogenesisGO:00488581290.014
angiogenesisGO:00015251470.014
small molecule biosynthetic processGO:00442831570.014
follicle stimulating hormone secretionGO:004688430.014
organ morphogenesisGO:00098871470.014
Fly
regulation of cell adhesionGO:00301551660.014
Human Mouse
endochondral bone morphogenesisGO:006035030.014
regulation of reactive oxygen species metabolic processGO:2000377410.014
somatic muscle developmentGO:000752510.014
glycoprotein metabolic processGO:00091001100.014
somitogenesisGO:000175620.014
single organismal cell cell adhesionGO:00163371480.014
sex determinationGO:000753030.014
response to fungusGO:000962040.014
forebrain generation of neuronsGO:002187230.014
central nervous system developmentGO:00074171230.014
cellular response to nitrogen compoundGO:19016991440.014
meiotic chromosome segregationGO:004513240.014
glial cell migrationGO:000834740.014
negative regulation of protein processingGO:00109551420.014
actin mediated cell contractionGO:0070252120.014
positive regulation of cytokine productionGO:00018191670.014
cell substrate adhesionGO:00315891320.014
neural tube closureGO:000184330.014
epithelium migrationGO:00901321190.014
protein dephosphorylationGO:0006470810.014
atp metabolic processGO:00460341760.014
regulation of cell growthGO:00015581350.014
negative regulation of cellular component movementGO:00512711060.014
establishment or maintenance of apical basal cell polarityGO:003508820.014
cranial nerve developmentGO:002154540.014
cellular response to cytokine stimulusGO:00713451810.014
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.014
limbic system developmentGO:002176130.014
neurological system processGO:00508771630.014
matingGO:000761810.014
long term memoryGO:000761620.014
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.014
negative regulation of organelle organizationGO:00106391260.014
regulation of homeostatic processGO:00328441210.013
regulation of transmembrane transportGO:00347621390.013
positive regulation of protein serine threonine kinase activityGO:00719021190.013
Fly
tissue regenerationGO:004224630.013
generation of neuronsGO:00486991520.013
positive regulation of locomotionGO:00400171860.013
cell junction organizationGO:0034330790.013
response to woundingGO:00096111680.013
i kappab kinase nf kappab signalingGO:00072491660.013
leukocyte activationGO:00453211640.013
positive regulation of cellular component movementGO:00512721810.013
mitotic cell cycle phase transitionGO:00447721620.013
post embryonic organ developmentGO:004856910.013
Fly
negative regulation of transferase activityGO:00513481240.013
engulfment of apoptotic cellGO:004365220.013
cellular metal ion homeostasisGO:00068751460.013
positive regulation of protein transportGO:00512221350.013
embryonic camera type eye developmentGO:003107620.013
visual behaviorGO:000763220.013
negative regulation of proteolysisGO:00458611320.013
thymus developmentGO:004853830.013
negative regulation of cellular catabolic processGO:0031330830.013
positive regulation of reactive oxygen species metabolic processGO:2000379240.013
protein localization to nucleusGO:00345041360.013
hindlimb morphogenesisGO:003513720.013
calcium ion transportGO:00068161470.013
negative regulation of catabolic processGO:00098951040.013
peptidyl tyrosine phosphorylationGO:00181081700.013
positive regulation of reactive oxygen species biosynthetic processGO:190342820.013
sequestering of metal ionGO:0051238240.013
t cell differentiation in thymusGO:003307740.013
myosin filament assemblyGO:003103420.013
chemotaxisGO:00069351570.013
specification of organ identityGO:001009230.013
divalent metal ion transportGO:00708381520.013
positive regulation of secretion by cellGO:19035321080.013
organelle fissionGO:00482851490.013
regulation of axon guidanceGO:190266730.013
head developmentGO:00603221080.013
regulation of endopeptidase activityGO:00525481700.013
atp catabolic processGO:00062001570.013
blood vessel morphogenesisGO:00485141620.013
epithelial cell proliferationGO:00506731280.013
negative regulation of cell motilityGO:20001461040.013
epithelial cell migrationGO:00106311190.013
protein importGO:00170381300.013
regulation of rho protein signal transductionGO:0035023790.013
regulation of bindingGO:00510981110.013
myeloid cell differentiationGO:00300991170.013
negative regulation of immune system processGO:00026831360.013
positive regulation of cell cycleGO:00457871400.012
positive regulation of immune responseGO:00507781590.012
embryo developmentGO:00097901230.012
Fly
midgut developmentGO:000749410.012
regulation of dephosphorylationGO:0035303960.012
metal ion homeostasisGO:00550651690.012
peptidyl lysine modificationGO:00182051440.012
lens development in camera type eyeGO:000208820.012
positive regulation of axon extensionGO:004577340.012
rna interferenceGO:001624640.012
regulation of cell projection organizationGO:00313441070.012
muscle system processGO:0003012810.012
canonical wnt signaling pathwayGO:00600701160.012
stress activated protein kinase signaling cascadeGO:0031098940.012
response to hypoxiaGO:0001666960.012
negative regulation of cell migrationGO:00303361020.012
cell cell signalingGO:00072671550.012
regulation of membrane potentialGO:0042391950.012
response to inorganic substanceGO:00100351270.012
sequestering of calcium ionGO:0051208170.012
regulation of meiotic cell cycleGO:005144540.012
immune effector processGO:00022521590.012
divalent inorganic cation homeostasisGO:00725071360.012
photoreceptor cell differentiationGO:004653020.012
rna processingGO:00063962550.012
regulation of i kappab kinase nf kappab signalingGO:00431221620.012
regulation of leukocyte activationGO:00026941150.012
cellular chemical homeostasisGO:00550821800.012
response to radiationGO:00093141510.012
regulation of actin cytoskeleton organizationGO:00329561160.012
phospholipid metabolic processGO:0006644990.012
intrinsic apoptotic signaling pathwayGO:00971931270.012
embryonic forelimb morphogenesisGO:003511540.012
nucleoside monophosphate catabolic processGO:00091251590.012
positive regulation of secretionGO:00510471160.012
response to oxygen levelsGO:00704821000.012
cell migration involved in gastrulationGO:004207410.012
neuron projection regenerationGO:003110210.012
regulation of apoptotic signaling pathwayGO:20012331750.012
somatic stem cell divisionGO:004810310.012
wound healingGO:00420601150.012

CYTH3 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.038
disease of metabolismDOID:00146672950.027
cardiovascular system diseaseDOID:12871060.022
central nervous system diseaseDOID:3311860.020
nervous system diseaseDOID:8634310.020
immune system diseaseDOID:29141550.020
muscular diseaseDOID:00800001140.020
muscle tissue diseaseDOID:661130.020
myopathyDOID:4231040.020
inherited metabolic disorderDOID:6552420.020
disease of cellular proliferationDOID:145661740.019
sensory system diseaseDOID:00501552030.018
connective tissue diseaseDOID:651090.018
cancerDOID:1621670.017
organ system cancerDOID:00506861640.017
bone diseaseDOID:0080001880.016
heart diseaseDOID:114680.014
eye and adnexa diseaseDOID:14921500.014
eye diseaseDOID:56141490.013
muscular dystrophyDOID:9884510.013
brain diseaseDOID:936730.012
retinal diseaseDOID:56791180.012
hematopoietic system diseaseDOID:741000.012