Homo sapiens

10 known processes

PAH

phenylalanine hydroxylase

(Aliases: PKU1,PH,PKU)

PAH biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
chemical homeostasisGO:00488783060.308
anion transportGO:00068201610.299
cellular amino acid metabolic processGO:00065201160.262
Rat Fly
response to oxygen containing compoundGO:19017003690.260
Human
organic hydroxy compound metabolic processGO:19016151470.246
Human
cellular lipid metabolic processGO:00442553030.233
lipid metabolic processGO:00066293810.222
small molecule biosynthetic processGO:00442831570.216
Rat
organic acid biosynthetic processGO:0016053970.209
Rat
monocarboxylic acid metabolic processGO:00327871850.202
organic anion transportGO:00157111030.187
cellular ketone metabolic processGO:0042180800.141
urate transportGO:001574730.136
cofactor metabolic processGO:0051186870.135
Rat
carboxylic acid biosynthetic processGO:0046394970.135
Rat
transmembrane transportGO:00550853990.121
regulation of hormone levelsGO:00108171250.116
oxidation reduction processGO:00551143960.115
cellular amine metabolic processGO:0044106410.112
fatty acid omega oxidationGO:001043020.106
steroid metabolic processGO:0008202940.105
lipid biosynthetic processGO:00086101770.102
cellular response to oxygen containing compoundGO:19017012760.101
organonitrogen compound biosynthetic processGO:19015662000.094
Human Rat
vitamin e metabolic processGO:004236010.091
sulfur compound metabolic processGO:00067901010.088
response to hormoneGO:00097251750.088
fatty acid metabolic processGO:00066311150.087
ion transmembrane transportGO:00342203380.084
regulation of cellular ketone metabolic processGO:0010565500.082
response to nitrogen compoundGO:19016981840.081
lipid catabolic processGO:0016042840.080
post embryonic developmentGO:000979120.079
menaquinone metabolic processGO:000923330.078
cellular response to genisteinGO:007141210.073
regulation of high density lipoprotein particle clearanceGO:001098220.073
small molecule catabolic processGO:0044282920.072
Fly
regulation of cellular amine metabolic processGO:0033238110.072
carboxylic acid catabolic processGO:0046395710.071
Fly
regulation of cellular amino acid metabolic processGO:000652160.071
coenzyme metabolic processGO:0006732650.071
Rat
cation transportGO:00068123310.069
system processGO:00030083490.065
Fly
regenerationGO:003109940.065
organic acid catabolic processGO:0016054710.065
Fly
vitamin k catabolic processGO:004237720.062
ion homeostasisGO:00508012300.061
long chain fatty acid metabolic processGO:0001676300.060
cellular homeostasisGO:00197251960.059
cation homeostasisGO:00550801890.058
cellular response to hormone stimulusGO:00328701250.057
negative regulation of icosanoid secretionGO:003230420.057
cation transmembrane transportGO:00986552380.057
cellular response to endogenous stimulusGO:00714953360.055
monocarboxylic acid biosynthetic processGO:0072330670.055
positive regulation of transportGO:00510503360.054
nitrogen compound transportGO:00717051910.054
response to organic cyclic compoundGO:00140702040.053
phylloquinone metabolic processGO:004237420.053
single organism carbohydrate metabolic processGO:00447231930.052
sensory perception of smellGO:000760820.051
response to lipidGO:00339932060.051
organic hydroxy compound transportGO:0015850630.050
inorganic ion transmembrane transportGO:00986602310.049
inorganic cation transmembrane transportGO:00986621940.048
positive regulation of cellular amino acid metabolic processGO:004576430.047
response to organonitrogen compoundGO:00102431560.047
amine metabolic processGO:0009308440.046
locomotory behaviorGO:000762610.045
negative regulation of multicellular organismal processGO:00512413170.044
icosanoid catabolic processGO:190152320.044
negative regulation of protein metabolic processGO:00512483910.042
carbohydrate metabolic processGO:00059752070.042
response to abiotic stimulusGO:00096283360.041
Human
epoxygenase p450 pathwayGO:001937330.041
positive regulation of cellular amine metabolic processGO:003324070.041
carboxylic acid transportGO:0046942630.040
alkaloid metabolic processGO:000982040.040
regulation of ion transportGO:00432691890.040
quinone catabolic processGO:190166220.039
cellular chemical homeostasisGO:00550821800.039
alpha amino acid metabolic processGO:1901605720.039
Rat Fly
secretion by cellGO:00329402260.038
multicellular organismal agingGO:001025930.038
protein processingGO:00164852260.038
metal ion transportGO:00300012720.037
negative regulation of catalytic activityGO:00430863350.037
carbohydrate derivative biosynthetic processGO:19011372070.037
secretionGO:00469032540.037
glycerolipid metabolic processGO:00464861070.037
thyroid hormone transportGO:007032720.036
g protein coupled receptor signaling pathwayGO:00071862070.036
female gamete generationGO:000729220.036
metal ion homeostasisGO:00550651690.036
androgen biosynthetic processGO:000670230.035
organic acid transportGO:0015849650.035
cellular lipid catabolic processGO:0044242650.035
divalent inorganic cation homeostasisGO:00725071360.035
leukotriene b4 metabolic processGO:003610220.035
lipid transportGO:0006869900.034
alcohol metabolic processGO:00060661140.034
response to drugGO:0042493810.034
determination of adult lifespanGO:000834020.034
vitamin metabolic processGO:0006766260.033
cellular response to organonitrogen compoundGO:00714171240.033
organic hydroxy compound biosynthetic processGO:1901617710.032
Human
cellular cation homeostasisGO:00300031630.032
immune responseGO:00069553070.031
purine ribonucleoside metabolic processGO:00461284370.031
regulation of proteolysisGO:00301622930.031
leukotriene catabolic processGO:003610020.031
segmentationGO:003528240.031
vitamin k biosynthetic processGO:004237120.030
hindbrain developmentGO:003090230.030
neurological system processGO:00508771630.030
Fly
regulation of secretionGO:00510461940.029
regulation of transferase activityGO:00513383550.029
regulation of secretion by cellGO:19035301770.029
terpenoid metabolic processGO:0006721270.029
protein maturationGO:00516042330.029
protein catabolic processGO:00301633250.028
negative regulation of transportGO:00510511760.028
oogenesisGO:004847720.028
cellular response to organic cyclic compoundGO:00714071270.028
organophosphate catabolic processGO:00464344300.028
menaquinone catabolic processGO:004236120.028
alpha amino acid catabolic processGO:1901606260.028
Fly
negative regulation of cellular protein metabolic processGO:00322693530.028
anion transmembrane transportGO:0098656760.027
estrogen catabolic processGO:000671110.026
regulation of response to external stimulusGO:00321012220.026
lipid localizationGO:00108761060.026
cellular response to hydroxyisoflavoneGO:007141310.026
defense responseGO:00069523150.025
inorganic anion transmembrane transportGO:0098661470.025
hormone metabolic processGO:0042445610.025
growthGO:00400072020.025
cellular response to nitrogen compoundGO:19016991440.025
nitrogen cycle metabolic processGO:007194130.025
negative regulation of protein maturationGO:19033181420.025
regulation of body fluid levelsGO:0050878990.024
cytoplasmic transportGO:00164823790.024
response to external biotic stimulusGO:00432072610.024
diterpenoid metabolic processGO:0016101200.024
response to nutrient levelsGO:0031667810.024
sensory perceptionGO:00076001030.024
cell fate determinationGO:000170930.024
response to extracellular stimulusGO:0009991850.024
cellular response to lipidGO:00713961270.024
cellular hormone metabolic processGO:0034754410.024
biological adhesionGO:00226103310.023
steroid biosynthetic processGO:0006694460.023
response to inorganic substanceGO:00100351270.023
cellular amino acid biosynthetic processGO:0008652300.023
Rat
single organism cellular localizationGO:19025803320.023
negative regulation of protein processingGO:00109551420.023
rhythmic behaviorGO:000762220.023
urea metabolic processGO:001962730.023
regulation of growthGO:00400081650.023
urate metabolic processGO:0046415110.023
regulation of cell cycleGO:00517263930.023
cellular response to growth factor stimulusGO:00713631970.023
cellular modified amino acid metabolic processGO:0006575640.023
response to woundingGO:00096111680.023
negative regulation of phosphorus metabolic processGO:00105632670.023
monovalent inorganic cation transportGO:00156721280.023
regulation of protein maturationGO:19033171500.023
positive regulation of synaptic transmissionGO:005080640.023
negative regulation of cellular component organizationGO:00511292350.023
negative regulation of phosphate metabolic processGO:00459362670.022
positive regulation of transferase activityGO:00513472270.022
ribonucleoside triphosphate metabolic processGO:00091994120.022
acylglycerol metabolic processGO:0006639270.022
nervous system developmentGO:00073992930.022
positive regulation of protein phosphorylationGO:00019343130.022
fatty acid derivative catabolic processGO:190156920.022
memoryGO:000761330.022
Fly
cellular metal ion homeostasisGO:00068751460.022
regulation of protein kinase activityGO:00458592890.022
interspecies interaction between organismsGO:00444191560.022
fatty acid biosynthetic processGO:0006633460.022
isoquinoline alkaloid metabolic processGO:003307610.022
regulation of protein processingGO:00706131500.021
cellular response to xenobiotic stimulusGO:0071466290.021
behaviorGO:00076101120.021
Fly
tissue regenerationGO:004224630.021
vesicle mediated transportGO:00161923710.021
Fly
maintenance of locationGO:00512351120.021
regulation of kinase activityGO:00435493140.021
response to steroid hormoneGO:0048545800.021
isoprenoid metabolic processGO:0006720390.021
limbic system developmentGO:002176130.021
negative regulation of hydrolase activityGO:00513461820.021
cellular ion homeostasisGO:00068731680.021
multi organism cellular processGO:00447641560.021
regulation of cell cycle processGO:00105642660.021
positive regulation of cellular catabolic processGO:00313312840.021
positive regulation of kinase activityGO:00336742040.021
icosanoid metabolic processGO:0006690350.021
response to biotic stimulusGO:00096072760.021
circadian behaviorGO:004851220.021
nucleotide catabolic processGO:00091664080.021
intracellular protein transportGO:00068862700.021
reactive oxygen species biosynthetic processGO:190340940.020
cellular calcium ion homeostasisGO:00068741170.020
signal transduction by phosphorylationGO:00230142970.020
positive regulation of cellular component organizationGO:00511303760.020
purine ribonucleoside triphosphate metabolic processGO:00092054110.020
negative regulation of cellular amine metabolic processGO:003323930.020
regulation of protein localizationGO:00328802960.020
regulation of locomotionGO:00400123290.020
positive regulation of phosphorylationGO:00423273940.020
cell developmentGO:00484683280.020
cellular response to external stimulusGO:00714961110.020
adult locomotory behaviorGO:000834410.020
regulation of immune responseGO:00507762010.019
response to other organismGO:00517072610.019
dephosphorylationGO:00163112090.019
morphogenesis of embryonic epitheliumGO:001633140.019
single organism membrane organizationGO:00448022680.019
leukotriene b4 catabolic processGO:003610120.019
positive regulation of catabolic processGO:00098963100.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
detection of stimulusGO:0051606850.019
reactive nitrogen species metabolic processGO:200105730.019
response to peptide hormoneGO:0043434610.019
innate immune responseGO:00450871780.019
regulation of mapk cascadeGO:00434082620.019
response to cytokineGO:00340972320.019
sodium ion transmembrane transportGO:0035725590.019
cell growthGO:00160491600.019
regulation of reactive oxygen species biosynthetic processGO:190342630.019
cellular macromolecule catabolic processGO:00442653800.019
sensory perception of chemical stimulusGO:0007606380.019
ribonucleoside triphosphate catabolic processGO:00092033910.019
glucose homeostasisGO:0042593310.019
cellular amide metabolic processGO:0043603690.019
phospholipid metabolic processGO:0006644990.018
regulation of synaptic plasticityGO:004816730.018
amino acid transportGO:0006865280.018
toxin metabolic processGO:000940440.018
purine nucleotide catabolic processGO:00061954050.018
protein localization to organelleGO:00333652800.018
nucleoside triphosphate metabolic processGO:00091414220.018
metencephalon developmentGO:002203720.018
purine ribonucleoside triphosphate catabolic processGO:00092073910.018
regulation of lipid biosynthetic processGO:0046890470.018
positive regulation of protein kinase activityGO:00458601900.018
positive regulation of hydrolase activityGO:00513453310.018
renal water homeostasisGO:000309140.018
protein targetingGO:00066051870.018
oxidative demethylationGO:0070989110.018
reactive oxygen species metabolic processGO:0072593750.018
divalent metal ion transportGO:00708381520.018
monosaccharide metabolic processGO:0005996740.018
purine containing compound catabolic processGO:00725234110.017
regulation of establishment of protein localizationGO:00702012420.017
detection of chemical stimulus involved in sensory perception of smellGO:005091120.017
mitotic cell cycle processGO:19030472860.017
response to peptideGO:1901652650.017
anterior posterior axis specificationGO:000994820.017
membrane organizationGO:00610242920.017
actin filament based processGO:00300292240.017
purine nucleoside triphosphate metabolic processGO:00091444120.017
nucleoside triphosphate catabolic processGO:00091433940.017
mitotic cell cycleGO:00002783260.017
regulation of response to woundingGO:19030341010.017
wound healingGO:00420601150.017
purine containing compound biosynthetic processGO:0072522880.017
mapk cascadeGO:00001652880.017
enzyme linked receptor protein signaling pathwayGO:00071673030.017
ras protein signal transductionGO:0007265730.017
regulation of anatomical structure morphogenesisGO:00226032860.017
sodium ion transportGO:0006814610.017
small gtpase mediated signal transductionGO:0007264780.017
wnt signaling pathwayGO:00160551560.017
purine nucleotide biosynthetic processGO:0006164840.017
regulation of multi organism processGO:00439001570.016
gland developmentGO:0048732480.016
tripartite regional subdivisionGO:000735120.016
response to activityGO:001482300.016
positive regulation of developmental processGO:00510943140.016
ribonucleotide catabolic processGO:00092614050.016
positive regulation of immune system processGO:00026842830.016
protein modification by small protein conjugationGO:00324463420.016
carbohydrate homeostasisGO:0033500310.016
cell adhesionGO:00071553250.016
negative regulation of apoptotic processGO:00430663160.016
regulation of intracellular transportGO:00323861950.016
regulation of cellular component movementGO:00512703340.016
renal system process involved in regulation of blood volumeGO:000197740.016
sensory perception of painGO:001923340.016
regulation of endopeptidase activityGO:00525481700.016
ribonucleoside catabolic processGO:00424544060.016
cellular component morphogenesisGO:00329893140.016
regulation of cell differentiationGO:00455953930.016
inner ear morphogenesisGO:004247240.016
response to fungusGO:000962040.016
regulation of anion transportGO:0044070250.016
unsaturated fatty acid metabolic processGO:0033559370.016
circulatory system processGO:00030131130.016
negative regulation of cell deathGO:00605483450.016
cell projection organizationGO:00300302520.016
oocyte developmentGO:004859910.016
neutral lipid catabolic processGO:0046461120.016
viral processGO:00160321460.016
endocytosisGO:00068971590.016
Fly
apoptotic signaling pathwayGO:00971902680.016
cellular response to peptide hormone stimulusGO:0071375560.016
regulation of protein serine threonine kinase activityGO:00719001790.016
purine ribonucleoside monophosphate metabolic processGO:00091671860.016
fat soluble vitamin metabolic processGO:0006775190.016
regulation of cell migrationGO:00303342890.016
regulation of lipid metabolic processGO:0019216960.016
organophosphate biosynthetic processGO:00904071630.015
rho protein signal transductionGO:0007266260.015
nucleoside phosphate biosynthetic processGO:19012931090.015
positive regulation of secretionGO:00510471160.015
glycosyl compound catabolic processGO:19016584130.015
divalent inorganic cation transportGO:00725111580.015
forebrain neuron differentiationGO:002187930.015
response to growth factorGO:00708482050.015
positive regulation of ion transportGO:0043270870.015
cell morphogenesisGO:00009022960.015
nucleoside catabolic processGO:00091644080.015
nucleoside phosphate catabolic processGO:19012924120.015
atp metabolic processGO:00460341760.015
establishment of protein localization to organelleGO:00725941720.015
positive regulation of cell deathGO:00109422630.015
symbiosis encompassing mutualism through parasitismGO:00444031560.015
arachidonic acid metabolic processGO:0019369140.015
blastoderm segmentationGO:000735020.015
neuroblast proliferationGO:000740540.015
photoreceptor cell differentiationGO:004653020.015
blood circulationGO:00080151130.015
regulation of purine nucleotide metabolic processGO:19005422640.015
regulation of wound healingGO:0061041560.015
cellular divalent inorganic cation homeostasisGO:00725031280.015
protein ubiquitinationGO:00165673140.015
regulation of peptidase activityGO:00525471800.015
oocyte differentiationGO:000999420.015
nucleoside monophosphate metabolic processGO:00091231910.015
negative regulation of protein modification processGO:00314002000.015
negative regulation of proteolysisGO:00458611320.015
inorganic anion transportGO:0015698600.015
naphthalene metabolic processGO:001893110.015
protein activation cascadeGO:0072376220.015
protein localization to membraneGO:00726571600.015
sterol transportGO:0015918390.015
cellular response to cytokine stimulusGO:00713451810.015
negative regulation of cell cycleGO:00457861930.015
peripheral nervous system developmentGO:000742220.014
neutral lipid metabolic processGO:0006638270.014
regulation of wnt signaling pathwayGO:00301111230.014
cellular response to nutrient levelsGO:0031669690.014
cellular protein catabolic processGO:00442572610.014
cellular macromolecular complex assemblyGO:00346223240.014
salivary gland morphogenesisGO:000743540.014
long chain fatty acid catabolic processGO:004275830.014
regulation of vesicle mediated transportGO:00606271300.014
regulation of nucleotide metabolic processGO:00061402690.014
cell cell signalingGO:00072671550.014
proteolysis involved in cellular protein catabolic processGO:00516032440.014
hormone transportGO:0009914680.014
purine ribonucleoside catabolic processGO:00461303980.014
protein oligomerizationGO:00512591730.014
bile acid metabolic processGO:0008206140.014
negative regulation of programmed cell deathGO:00430693210.014
purine nucleoside triphosphate catabolic processGO:00091463920.014
spermatid differentiationGO:004851540.014
neuromuscular junction developmentGO:000752830.014
forebrain generation of neuronsGO:002187230.014
fatty acid derivative metabolic processGO:1901568350.014
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.014
regulation of protein catabolic processGO:00421761550.014
cardiac muscle cell contractionGO:008600340.014
regulation of protein transportGO:00512232130.014
pressure natriuresisGO:000309520.014
regulation of neural precursor cell proliferationGO:200017740.014
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathwayGO:003562540.014
sequestering of metal ionGO:0051238240.014
posttranscriptional regulation of gene expressionGO:00106082130.014
regulation of cell growthGO:00015581350.014
purine nucleoside catabolic processGO:00061523980.014
response to acid chemicalGO:0001101660.014
vitamin catabolic processGO:000911160.014
regulation of cytoplasmic transportGO:19036491490.014
regulation of sequence specific dna binding transcription factor activityGO:00510902110.014
negative regulation of response to external stimulusGO:0032102830.014
ribonucleoside monophosphate metabolic processGO:00091611870.014
purine nucleoside monophosphate metabolic processGO:00091261860.014
negative regulation of growthGO:0045926970.013
negative regulation of intracellular signal transductionGO:19025321830.013
neural crest cell developmentGO:001403230.013
ribonucleotide biosynthetic processGO:0009260810.013
cellular protein complex assemblyGO:00436231880.013
embryonic epithelial tube formationGO:000183840.013
protein acylationGO:00435431380.013
somatic stem cell maintenanceGO:003501940.013
positive regulation of cell migrationGO:00303351720.013
positive regulation of nucleoside metabolic processGO:00459791860.013
regulation of system processGO:00440571010.013
positive regulation of cellular component movementGO:00512721810.013
positive regulation of apoptotic processGO:00430652460.013
purine ribonucleotide catabolic processGO:00091544040.013
lung alveolus developmentGO:004828640.013
peptidyl tyrosine modificationGO:00182121700.013
sulfur compound biosynthetic processGO:0044272380.013
hippocampus developmentGO:002176610.013
sialic acid transportGO:001573910.013
positive regulation of cell proliferationGO:00082843010.013
actin filament based movementGO:0030048170.013
response to insulinGO:0032868450.013
epithelium developmentGO:00604292270.013
defense response to fungusGO:005083240.013
viral life cycleGO:00190581320.013
cellular amino acid catabolic processGO:0009063310.013
Fly
compound eye developmentGO:004874910.013
response to axon injuryGO:004867810.013
regulation of cytoskeleton organizationGO:00514931770.013
positive regulation of organic acid transportGO:003289230.013
testosterone biosynthetic processGO:006137020.013
negative regulation of synaptic transmissionGO:005080520.013
negative regulation of developmental processGO:00510932470.013
serotonin transportGO:000683730.012
somitogenesisGO:000175620.012
detection of mechanical stimulusGO:005098240.012
regulation of cell motilityGO:20001452990.012
generation of neuronsGO:00486991520.012
regulation of membrane potentialGO:0042391950.012
cellular organohalogen metabolic processGO:009034520.012
negative regulation of insulin secretion involved in cellular response to glucose stimulusGO:006117910.012
drug metabolic processGO:0017144190.012
circulatory system developmentGO:00723592620.012
hexose metabolic processGO:0019318550.012
cellular response to peptideGO:1901653590.012
response to organophosphorusGO:0046683410.012
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.012
anatomical structure formation involved in morphogenesisGO:00486462840.012
nucleocytoplasmic transportGO:00069131760.012
positive regulation of purine nucleotide metabolic processGO:19005442270.012
blood coagulationGO:0007596760.012
glycoprotein metabolic processGO:00091001100.012
cellular carbohydrate metabolic processGO:0044262840.012
response to bacteriumGO:00096171440.012
glycerophospholipid metabolic processGO:0006650840.012
response to oxidative stressGO:00069791210.012
detection of stimulus involved in sensory perceptionGO:0050906430.012
neural tube formationGO:000184130.012
cellular response to glucocorticoid stimulusGO:007138540.012
cofactor biosynthetic processGO:0051188310.012
syncytium formation by plasma membrane fusionGO:000076820.012
lipid modificationGO:0030258840.012
positive regulation of programmed cell deathGO:00430682490.012
positive regulation of nucleotide metabolic processGO:00459812300.012
canonical wnt signaling pathwayGO:00600701160.012
spermatid developmentGO:000728640.012
response to oxygen levelsGO:00704821000.012
Human
rna processingGO:00063962550.012
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.012
triglyceride metabolic processGO:0006641230.012
purine ribonucleotide biosynthetic processGO:0009152790.012
primary neural tube formationGO:001402030.012
cellular response to extracellular stimulusGO:0031668720.012
cyclic purine nucleotide metabolic processGO:0052652600.012
negative regulation of endopeptidase activityGO:0010951840.012
nucleotide biosynthetic processGO:00091651090.012
positive regulation of immune responseGO:00507781590.011
protein homooligomerizationGO:00512601000.011
protein localization to nucleusGO:00345041360.011
response to xenobiotic stimulusGO:0009410300.011
cellular response to transforming growth factor beta stimulusGO:0071560940.011
regulation of metal ion transportGO:00109591200.011

PAH disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.126
inherited metabolic disorderDOID:6552420.070
steroid inherited metabolic disorderDOID:170190.040
lipid metabolism disorderDOID:3146260.040
sensory system diseaseDOID:00501552030.025
nervous system diseaseDOID:8634310.025
cancerDOID:1621670.022
disease of cellular proliferationDOID:145661740.022
organ system cancerDOID:00506861640.022
immune system diseaseDOID:29141550.020
amino acid metabolic disorderDOID:9252500.017
hematopoietic system diseaseDOID:741000.014
eye diseaseDOID:56141490.014
eye and adnexa diseaseDOID:14921500.014
musculoskeletal system diseaseDOID:172230.014
central nervous system diseaseDOID:3311860.014
acquired metabolic diseaseDOID:0060158580.013
connective tissue diseaseDOID:651090.012
bone diseaseDOID:0080001880.012
cardiovascular system diseaseDOID:12871060.011