Homo sapiens

61 known processes

GAPDH

glyceraldehyde-3-phosphate dehydrogenase

(Aliases: MGC88685,GAPD,G3PD)

GAPDH biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
monocarboxylic acid metabolic processGO:00327871850.999
Fly
glomerular mesangial cell developmentGO:007214410.999
single organism carbohydrate catabolic processGO:0044724330.998
Fly
oxidation reduction processGO:00551143960.997
Fly
regulation of coenzyme metabolic processGO:005119630.993
cellular homeostasisGO:00197251960.992
carbohydrate catabolic processGO:0016052360.988
Fly
glycolytic processGO:0006096170.982
Fly
renal interstitial fibroblast developmentGO:007214110.982
purine nucleotide biosynthetic processGO:0006164840.965
pyruvate metabolic processGO:0006090260.964
Fly
striated muscle contractionGO:0006941520.952
single organism carbohydrate metabolic processGO:00447231930.937
Fly
glomerular mesangial cell differentiationGO:007200820.928
regulation of nucleotide metabolic processGO:00061402690.864
epithelial cell differentiationGO:00308551410.848
negative regulation of catalytic activityGO:00430863350.843
viral processGO:00160321460.822
organelle assemblyGO:00709251760.811
muscle cell cellular homeostasisGO:004671630.774
cellular response to hydrogen peroxideGO:0070301370.769
fructose metabolic processGO:000600030.755
purine ribonucleoside monophosphate metabolic processGO:00091671860.750
myoblast fusionGO:000752010.749
Fly
actin myosin filament slidingGO:003327560.733
anatomical structure homeostasisGO:00602491000.713
nicotinamide nucleotide metabolic processGO:0046496140.665
response to other organismGO:00517072610.662
cell developmentGO:00484683280.659
somatic muscle developmentGO:000752510.652
Fly
muscle contractionGO:0006936730.648
oxidoreduction coenzyme metabolic processGO:0006733190.623
system processGO:00030083490.604
determination of adult lifespanGO:000834020.603
Worm
cellular response to extracellular stimulusGO:0031668720.579
carbohydrate metabolic processGO:00059752070.561
Fly
prostaglandin metabolic processGO:0006693170.556
cellular response to oxidative stressGO:0034599850.548
oogenesisGO:004847720.537
cellular component morphogenesisGO:00329893140.510
mesangial cell differentiationGO:007200720.472
generation of precursor metabolites and energyGO:0006091680.469
Fly
multicellular organismal agingGO:001025930.462
Worm
positive regulation of cellular amino acid metabolic processGO:004576430.448
regulation of cellular amino acid metabolic processGO:000652160.432
ribonucleotide biosynthetic processGO:0009260810.422
anion transportGO:00068201610.413
atp metabolic processGO:00460341760.379
regulation of glucose metabolic processGO:0010906280.353
cytoplasmic transportGO:00164823790.344
somitogenesisGO:000175620.336
mitochondrial membrane organizationGO:0007006400.336
regulation of protein processingGO:00706131500.324
female gamete generationGO:000729220.319
nucleotide biosynthetic processGO:00091651090.314
kidney interstitial fibroblast differentiationGO:007207120.301
muscle cell differentiationGO:0042692630.298
Fly
response to abiotic stimulusGO:00096283360.296
response to xenobiotic stimulusGO:0009410300.295
response to virusGO:00096151260.291
anatomical structure formation involved in morphogenesisGO:00486462840.283
Fly
reproductive system developmentGO:0061458560.276
Worm
epithelium developmentGO:00604292270.275
positive regulation of catabolic processGO:00098963100.272
purine containing compound biosynthetic processGO:0072522880.267
neuron projection morphogenesisGO:0048812500.260
regulation of fibroblast proliferationGO:0048145320.256
taxisGO:00423301570.253
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.253
skeletal myofibril assemblyGO:001486630.244
negative regulation of protein phosphatase type 2b activityGO:003251320.237
cellular ion homeostasisGO:00068731680.223
cellular amino acid metabolic processGO:00065201160.222
atp biosynthetic processGO:0006754110.219
response to oxygen containing compoundGO:19017003690.217
cellular amide metabolic processGO:0043603690.215
regulation of cellular response to oxidative stressGO:1900407260.212
nuclear exportGO:0051168690.199
tissue homeostasisGO:0001894630.194
retina homeostasisGO:0001895420.188
cellular response to abiotic stimulusGO:00712141170.181
lipid metabolic processGO:00066293810.157
glucan metabolic processGO:0044042220.157
fructose 1 6 bisphosphate metabolic processGO:003038850.151
development of primary sexual characteristicsGO:0045137350.149
Worm
cellular response to dna damage stimulusGO:00069743790.143
secretionGO:00469032540.140
chemical homeostasisGO:00488783060.138
hexose catabolic processGO:001932070.137
myosin filament organizationGO:003103320.137
fatty acid metabolic processGO:00066311150.135
regulation of protein secretionGO:0050708860.134
regulation of cofactor metabolic processGO:005119330.132
vasculature developmentGO:00019441810.132
response to biotic stimulusGO:00096072760.130
cellular chemical homeostasisGO:00550821800.121
muscle system processGO:0003012810.120
positive regulation of cellular amine metabolic processGO:003324070.118
striated muscle cell differentiationGO:0051146430.118
Fly
chordate embryonic developmentGO:0043009340.117
reproductionGO:0000003630.116
negative regulation of phosphate metabolic processGO:00459362670.114
neural nucleus developmentGO:0048857470.114
formation of primary germ layerGO:0001704420.113
atp dependent chromatin remodelingGO:0043044250.113
interspecies interaction between organismsGO:00444191560.112
alpha amino acid metabolic processGO:1901605720.112
negative regulation of mitotic cell cycleGO:00459301020.111
reproductive structure developmentGO:0048608550.110
Worm
secretion by cellGO:00329402260.107
glutamate metabolic processGO:0006536100.105
regulation of cellular ketone metabolic processGO:0010565500.105
positive regulation of cell proliferationGO:00082843010.105
regulation of establishment of protein localizationGO:00702012420.105
myeloid cell homeostasisGO:0002262340.104
cellular response to external stimulusGO:00714961110.102
cell projection organizationGO:00300302520.101
endocytosisGO:00068971590.100
negative regulation of hydrolase activityGO:00513461820.100
positive regulation of reactive oxygen species metabolic processGO:2000379240.099
response to acid chemicalGO:0001101660.099
response to external biotic stimulusGO:00432072610.094
purine ribonucleoside triphosphate metabolic processGO:00092054110.093
immune effector processGO:00022521590.092
actin mediated cell contractionGO:0070252120.092
regulation of cellular amine metabolic processGO:0033238110.091
regulation of mitotic cell cycle phase transitionGO:19019901180.089
negative regulation of sequence specific dna binding transcription factor activityGO:0043433890.089
brain developmentGO:0007420970.088
covalent chromatin modificationGO:00165692540.086
glomerulus vasculature developmentGO:007201260.086
positive regulation of protein secretionGO:0050714600.086
regulation of secretion by cellGO:19035301770.085
metal ion transportGO:00300012720.084
post embryonic developmentGO:000979120.081
Worm
negative regulation of cell deathGO:00605483450.081
pentose phosphate shuntGO:000609850.081
platelet activationGO:0030168440.081
ribonucleoprotein complex assemblyGO:0022618780.080
nucleoside triphosphate biosynthetic processGO:0009142200.080
mitotic cell cycle processGO:19030472860.079
response to decreased oxygen levelsGO:0036293960.077
ribonucleoside biosynthetic processGO:0042455250.077
multi organism cellular processGO:00447641560.074
positive regulation of secretionGO:00510471160.074
cellular response to cytokine stimulusGO:00713451810.074
regulation of oxidative stress induced cell deathGO:1903201240.073
cell part morphogenesisGO:00329901370.072
rna export from nucleusGO:0006405330.071
regulation of carbohydrate catabolic processGO:0043470110.070
purine ribonucleoside biosynthetic processGO:0046129230.069
symbiosis encompassing mutualism through parasitismGO:00444031560.069
regulation of cellular carbohydrate catabolic processGO:0043471110.068
protein oxidationGO:001815850.068
cellular carbohydrate metabolic processGO:0044262840.066
regulation of mitochondrial membrane permeability involved in apoptotic processGO:1902108180.066
nucleoside monophosphate metabolic processGO:00091231910.065
striated muscle myosin thick filament assemblyGO:007168820.065
regulation of protein maturationGO:19033171500.065
regulation of cell cycle processGO:00105642660.064
nucleoside triphosphate metabolic processGO:00091414220.064
regulation of intracellular transportGO:00323861950.063
agingGO:0007568660.063
Worm
regulation of cytokine productionGO:00018172320.063
cell adhesionGO:00071553250.062
protein secretionGO:0009306980.062
monosaccharide metabolic processGO:0005996740.062
internal peptidyl lysine acetylationGO:0018393970.061
immune responseGO:00069553070.061
cell cycle phase transitionGO:00447701730.060
dicarboxylic acid catabolic processGO:004364990.059
protein acylationGO:00435431380.058
negative regulation of apoptotic processGO:00430663160.058
internal protein amino acid acetylationGO:00064751010.056
response to metal ionGO:0010038840.055
organic acid biosynthetic processGO:0016053970.054
hemopoiesisGO:00300971800.054
kidney vasculature developmentGO:006144070.053
head developmentGO:00603221080.052
regulation of carbohydrate metabolic processGO:0006109540.052
type i interferon signaling pathwayGO:0060337110.052
negative regulation of cell cycleGO:00457861930.052
response to hypoxiaGO:0001666960.052
sodium ion transportGO:0006814610.052
i kappab kinase nf kappab signalingGO:00072491660.052
multicellular organismal homeostasisGO:0048871670.051
peptidyl cysteine modificationGO:001819890.050
regulation of transferase activityGO:00513383550.050
leukocyte proliferationGO:0070661740.048
dna integrity checkpointGO:0031570710.047
response to radiationGO:00093141510.045
single organism cell adhesionGO:00986021790.045
response to reactive oxygen speciesGO:0000302610.045
positive regulation of bindingGO:0051099450.044
signal releaseGO:0023061700.044
organelle inheritanceGO:004830820.044
lipid storageGO:0019915280.044
Worm
energy derivation by oxidation of organic compoundsGO:0015980430.044
pyridine nucleotide metabolic processGO:0019362140.044
defense responseGO:00069523150.043
pattern specification processGO:0007389430.042
regulation of cell cycleGO:00517263930.042
hexose metabolic processGO:0019318550.041
blood circulationGO:00080151130.041
positive regulation of secretion by cellGO:19035321080.041
mitotic cell cycle phase transitionGO:00447721620.041
neuron differentiationGO:00301821380.040
protein depolymerizationGO:0051261300.039
negative regulation of cytokine productionGO:0001818820.039
regulation of cell growthGO:00015581350.039
negative regulation of cell cycle phase transitionGO:1901988890.037
regulation of cell cycle phase transitionGO:19019871260.037
central nervous system developmentGO:00074171230.037
regulation of anatomical structure morphogenesisGO:00226032860.037
cellular response to reactive oxygen speciesGO:0034614500.036
regulation of secretionGO:00510461940.036
blood coagulationGO:0007596760.036
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919490.036
metencephalon developmentGO:002203720.035
nucleobase containing compound transportGO:0015931510.035
ribonucleoside monophosphate biosynthetic processGO:0009156170.035
gonad developmentGO:0008406340.034
Worm
response to light stimulusGO:0009416870.034
negative regulation of oxidative stress induced cell deathGO:1903202170.033
response to hydrogen peroxideGO:0042542400.033
renal system developmentGO:0072001630.033
nucleoside triphosphate catabolic processGO:00091433940.033
cellular ketone metabolic processGO:0042180800.033
negative regulation of protein processingGO:00109551420.033
amine metabolic processGO:0009308440.033
proteolysis involved in cellular protein catabolic processGO:00516032440.032
ion homeostasisGO:00508012300.032
growthGO:00400072020.032
Worm
regulation of generation of precursor metabolites and energyGO:0043467270.032
protein ubiquitinationGO:00165673140.032
regulation of cell shapeGO:0008360480.032
embryo developmentGO:00097901230.032
Worm
regulation of multi organism processGO:00439001570.032
viral life cycleGO:00190581320.031
cell morphogenesis involved in differentiationGO:00009041440.031
cation homeostasisGO:00550801890.031
negative regulation of phosphatase activityGO:0010923610.030
actin filament based movementGO:0030048170.029
reproductive processGO:00224141060.029
Worm
carbohydrate homeostasisGO:0033500310.029
t cell differentiation in thymusGO:003307740.029
kidney developmentGO:0001822530.028
cell growthGO:00160491600.028
response to oxidative stressGO:00069791210.028
protein homooligomerizationGO:00512601000.028
protein acetylationGO:00064731160.028
purine ribonucleotide biosynthetic processGO:0009152790.028
fear responseGO:004259600.028
sex differentiationGO:0007548450.028
Worm
calcium ion transportGO:00068161470.028
cellular response to radiationGO:0071478650.027
reactive oxygen species metabolic processGO:0072593750.027
stem cell developmentGO:0048864690.027
nitrogen compound transportGO:00717051910.027
regulation of bindingGO:00510981110.027
sequestering of calcium ionGO:0051208170.027
cell activationGO:00017752130.027
regulation of lipid metabolic processGO:0019216960.026
protein processingGO:00164852260.026
developmental process involved in reproductionGO:0003006660.026
Worm
positive regulation of protein complex disassemblyGO:004324380.026
epithelial cell differentiation involved in kidney developmentGO:003585090.026
chromatin modificationGO:00165682980.026
ribonucleoside triphosphate metabolic processGO:00091994120.026
response to bacteriumGO:00096171440.026
cell differentiation involved in kidney developmentGO:006100590.026
regulation of peroxidase activityGO:200046820.025
cell divisionGO:00513011680.025
myosin filament assemblyGO:003103420.025
histone modificationGO:00165702510.025
regulation of cellular amide metabolic processGO:003424890.024
cation transmembrane transportGO:00986552380.024
regulation of proteasomal protein catabolic processGO:0061136870.024
positive regulation of leukocyte activationGO:0002696800.024
leukocyte mediated immunityGO:0002443590.024
mesoderm morphogenesisGO:0048332110.024
microvillus assemblyGO:003003320.023
cellular response to organonitrogen compoundGO:00714171240.023
cellular response to oxygen containing compoundGO:19017012760.023
myotube differentiationGO:0014902220.023
Fly
regulation of muscle system processGO:0090257530.023
respiratory burstGO:0045730120.023
regulation of i kappab kinase nf kappab signalingGO:00431221620.023
innate immune responseGO:00450871780.023
regulation of protein depolymerizationGO:1901879220.022
cellular macromolecular complex assemblyGO:00346223240.022
regulation of mitotic cell cycleGO:00073461890.022
single organism reproductive processGO:0044702980.022
Worm
regulation of cell morphogenesisGO:00226041530.022
positive regulation of cell deathGO:00109422630.022
negative regulation of organelle organizationGO:00106391260.022
negative regulation of cell proliferationGO:00082852280.022
negative regulation of protein transportGO:0051224750.022
nucleocytoplasmic transportGO:00069131760.022
coagulationGO:0050817780.021
positive regulation of organelle organizationGO:00106381950.021
cytokinesisGO:0000910960.021
negative regulation of cell cycle processGO:00109481210.021
regulation of phosphatase activityGO:0010921810.021
mitotic cell cycleGO:00002783260.020
peptidyl tyrosine phosphorylationGO:00181081700.020
behaviorGO:00076101120.020
organonitrogen compound biosynthetic processGO:19015662000.020
positive regulation of gtpase activityGO:00435471660.020
glycosyl compound catabolic processGO:19016584130.020
ribonucleoside monophosphate metabolic processGO:00091611870.020
developmental growthGO:0048589480.020
Worm
nucleotide catabolic processGO:00091664080.020
ribonucleoprotein complex biogenesisGO:00226131160.019
protein maturationGO:00516042330.019
regulation of circadian sleep wake cycleGO:004274920.019
receptor mediated endocytosisGO:0006898840.019
hemostasisGO:0007599760.019
response to inorganic substanceGO:00100351270.019
cellular response to uvGO:0034644320.019
carboxylic acid biosynthetic processGO:0046394970.019
cell death in response to oxidative stressGO:0036473290.019
heat acclimationGO:001028630.018
blood vessel developmentGO:00015681720.018
fibroblast proliferationGO:0048144330.018
cell cycle checkpointGO:00000751170.018
striated muscle cell developmentGO:0055002270.018
cofactor metabolic processGO:0051186870.018
endosome organizationGO:0007032200.018
regulation of receptor mediated endocytosisGO:0048259320.018
peptidyl cysteine oxidationGO:001817110.018
purine nucleoside triphosphate catabolic processGO:00091463920.018
response to extracellular stimulusGO:0009991850.018
regulation of glycolytic processGO:0006110100.018
glycosyl compound biosynthetic processGO:1901659270.018
ribonucleoside triphosphate catabolic processGO:00092033910.017
primary neural tube formationGO:001402030.017
telomere maintenance via recombinationGO:000072240.017
copulationGO:000762010.017
organelle fissionGO:00482851490.017
tissue regenerationGO:004224630.017
wound healingGO:00420601150.017
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:0042787370.017
negative regulation of cellular protein metabolic processGO:00322693530.017
positive regulation of growthGO:0045927580.017
Worm
defense response to other organismGO:00985421290.017
cytokine productionGO:00018162470.017
cellular cation homeostasisGO:00300031630.016
limbic system developmentGO:002176130.016
regulation of reactive oxygen species metabolic processGO:2000377410.016
negative regulation of programmed cell deathGO:00430693210.016
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:000046620.016
mitochondrial calcium ion transportGO:000685170.016
t cell proliferationGO:0042098450.016
ribose phosphate biosynthetic processGO:0046390820.016
regulation of cell activationGO:00508651250.016
peptidyl lysine modificationGO:00182051440.016
protein localization to nucleusGO:00345041360.016
cellular hyperosmotic responseGO:007147440.016
heart processGO:0003015620.016
negative regulation of mitotic cell cycle phase transitionGO:1901991850.015
purine ribonucleoside triphosphate catabolic processGO:00092073910.015
signal transduction in response to dna damageGO:0042770570.015
urogenital system developmentGO:0001655650.015
glucocorticoid catabolic processGO:000671310.015
negative regulation of endopeptidase activityGO:0010951840.015
regulation of mapk cascadeGO:00434082620.015
nadp metabolic processGO:0006739100.015
cell projection morphogenesisGO:00488581290.015
cell morphogenesisGO:00009022960.015
inorganic ion transmembrane transportGO:00986602310.014
carbohydrate derivative biosynthetic processGO:19011372070.014
purine nucleoside monophosphate metabolic processGO:00091261860.014
multicellular organismal reproductive processGO:0048609400.014
cellular carbohydrate catabolic processGO:0044275170.014
regulation of ion homeostasisGO:2000021730.014
cell death in response to hydrogen peroxideGO:0036474100.014
cellular amine metabolic processGO:0044106410.014
regulation of peptidyl tyrosine phosphorylationGO:00507301080.014
t cell activationGO:0042110990.014
mitotic cell cycle checkpointGO:0007093680.014
nervous system developmentGO:00073992930.014
regulation of protein transportGO:00512232130.014
negative regulation of phosphorus metabolic processGO:00105632670.014
regulation of neural precursor cell proliferationGO:200017740.014
purine ribonucleoside triphosphate biosynthetic processGO:0009206110.014
cellular response to toxic substanceGO:009723740.014
single organismal cell cell adhesionGO:00163371480.013
regulation of peptide transportGO:0090087620.013
positive regulation of mitochondrial membrane permeabilityGO:0035794170.013
negative regulation of immune system processGO:00026831360.013
signal transduction by phosphorylationGO:00230142970.013
regulation of hydrogen peroxide induced cell deathGO:1903205100.013
positive regulation of cellular catabolic processGO:00313312840.013
regulation of mitochondrion organizationGO:0010821540.013
alcohol metabolic processGO:00060661140.013
regulation of actin filament depolymerizationGO:0030834100.013
regulation of dna damage response signal transduction by p53 class mediatorGO:0043516200.013
negative regulation of kinase activityGO:00336731060.013
leukocyte activationGO:00453211640.013
cellular response to oxygen radicalGO:007145060.013
homotypic cell cell adhesionGO:0034109470.013
epithelial cell developmentGO:0002064340.012
cellular response to acid chemicalGO:0071229440.012
negative regulation of ion transportGO:0043271390.012
unsaturated fatty acid metabolic processGO:0033559370.012
negative regulation of proteolysisGO:00458611320.012
response to uvGO:0009411730.012
positive regulation of synaptic transmissionGO:005080640.012
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayGO:190102890.012
regulation of response to oxidative stressGO:1902882260.012
neural tube formationGO:000184130.012
positive regulation of transportGO:00510503360.012
protein deubiquitinationGO:0016579790.012
establishment of protein localization to membraneGO:00901501210.012
ribonucleoside bisphosphate metabolic processGO:003387570.012
transmembrane transportGO:00550853990.012
small molecule biosynthetic processGO:00442831570.012
substantia nigra developmentGO:0021762450.012
cell cell signalingGO:00072671550.012
negative regulation of intracellular transportGO:0032387600.012
multicellular organism reproductionGO:0032504420.012
purine nucleoside triphosphate metabolic processGO:00091444120.012
regulation of cellular response to stressGO:00801352440.011
response to oxygen levelsGO:00704821000.011
organic acid catabolic processGO:0016054710.011
hydrogen peroxide catabolic processGO:0042744130.011
regulation of response to external stimulusGO:00321012220.011
cellular divalent inorganic cation homeostasisGO:00725031280.011
negative regulation of protein metabolic processGO:00512483910.011
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.011
cell communication by electrical coupling involved in cardiac conductionGO:008606430.011
negative regulation of fibroblast proliferationGO:0048147120.011
axonogenesisGO:0007409310.011
regulation of response to reactive oxygen speciesGO:1901031120.011
nuclear transportGO:00511691790.011
regulation of lymphocyte proliferationGO:0050670640.011
dephosphorylationGO:00163112090.011
skeletal muscle thin filament assemblyGO:003024030.011
negative regulation of cell sizeGO:004579230.011
glomerulus developmentGO:0032835150.011
response to transition metal nanoparticleGO:1990267290.011
cellular lipid metabolic processGO:00442553030.011
nucleic acid transportGO:0050657390.011
embryonic placenta developmentGO:000189210.011
vesicle mediated transportGO:00161923710.011
inorganic anion transmembrane transportGO:0098661470.011
purine nucleoside triphosphate biosynthetic processGO:0009145110.011
negative regulation of transferase activityGO:00513481240.011
response to thyroid hormoneGO:009706690.011
mitotic cytokinetic processGO:190241020.010
response to endoplasmic reticulum stressGO:0034976490.010
regulation of mitochondrial membrane permeabilityGO:0046902250.010
regulation of oxidative phosphorylationGO:000208230.010
regulation of innate immune responseGO:0045088970.010
spermatid developmentGO:000728640.010
replicative cell agingGO:000130230.010
midbrain developmentGO:0030901450.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.010
cellular calcium ion homeostasisGO:00068741170.010

GAPDH disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
hemolytic anemiaDOID:583200.182
hematopoietic system diseaseDOID:741000.182
normocytic anemiaDOID:720200.182
congenital hemolytic anemiaDOID:58990.182
anemiaDOID:2355550.182
immune system diseaseDOID:29141550.182
acquired metabolic diseaseDOID:0060158580.133
disease of metabolismDOID:00146672950.133
sensory system diseaseDOID:00501552030.115
nonsyndromic deafnessDOID:0050563500.115
nervous system diseaseDOID:8634310.115
autosomal dominant nonsyndromic deafnessDOID:0050564230.115
auditory system diseaseDOID:2742530.115
carbohydrate metabolism diseaseDOID:0050013320.108
glucose metabolism diseaseDOID:4194320.042
musculoskeletal system diseaseDOID:172230.038
osteochondrodysplasiaDOID:2256350.031
bone development diseaseDOID:0080006550.031
connective tissue diseaseDOID:651090.031
bone diseaseDOID:0080001880.031